List of @tome entries for [NR_HUMAN_I30_201601] :


Volume and Hydrophobicity (binding site) are calculated from the 5 best predicted complexes.

Binding site residus color:Hydrophilic / Neutral / Hydrophobic / Very Hydrophobic (PH=7)

Text file for stat:Predicted_BSiteNR_HUMAN_I30_201601.txt

Text file for stat:Predicted_BSiteNR_HUMAN_I30_201601.distrib

Text file for stat:Predicted_BSiteNR_HUMAN_I30_201601.fasta

Text file for stat:Predicted_BSiteNR_HUMAN_I30_201601.muscle

CptReceptorsVolume (FPocket)Hydrophobicity score(FPocket) Binding Site Prediction on 5 best models [Protein/Ligand Contacts <4A] Ligands selected for calculation [theoretical Kd Limit=3]
1 H_NR0B1_DAX
2 H_NR0B2_SHP
3 H_NR1A1_THRa 815 (s=134) 31 (s=2) -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEQKPSKVECGSDPEENSARSPD----------------------------------------------------------------------------------------------------------------GKRKRKNGQCSLKTSMSGYIPSYLDK--------------------------------------------------------------------------------------------------DEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS-CK-YDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDS--KRVAK--------RKLIEQNRER-------------RRKEEMIRSL-----------------------------------------------------------------------------------------------------------------------------QQRPEPTPEEWDLIHIA------TEA-HRSTNA---------------QGSHWKQRRKFLPDDIGQS----PIVSMPDGD--------------KVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDT----LTLSG-EMAVKRE-QLK-NGGLG-VVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDR--------SGLLCVDKIEKSQEAYLLAFEHY--VNHRK----HNIPHFWPKLLMKERE---VQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQ----GPQVRQLEQQLGEA----------------GSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVCEDLAGNAASP------------------------------- PFA_D_4(1N46)[-8.8]; PFA_C_3(1N46)[-8.8]; OEF_A_2(2J4A)[-8.5]; G24_B_2(1Q4X)[-8.5]; 4HY_A_3(3D57)[-8.3];
4 H_NR1A2_THRb 642 (s=92) 31 (s=3) -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTPNSMTENGLTAWDKPKHCPDREHDW--KLVGMSEACLH-------------------------------------------------------------------------------------------------RKSHSERRSTLKNEQSSPHLIQTTWTSSI-----------------------FHLDHDDVNDQSV-------SSAQTFQTEEKKCKGY--------IPSYLDK-----------------------DELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYS-CK-YEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDS--KRLAK--------RKLIEENREK-------------RRREELQKSI-----------------------------------------------------------------------------------------------------------------------------GHKPEPTDEEWELIKTV------TEA-HVATNA---------------QGSHWKQKRKFLPEDIGQA----PIVNAPEGG--------------KVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESET----LTLNG-EMAVTRG-QLK-NGGLG-VVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDR--------PGLACVERIEKYQDSFLLAFEHY--INYRK----HHVTHFWPKLLMKVTD---L-RMIGACHA----------------SRFLHMKVEC---PTELFPPLFLEVFED------------------------------------------------------------------------------------------------------------------ G24_B_2(1Q4X)[-9.9]; PFA_C_3(1N46)[-9.6]; PFA_D_4(1N46)[-9.3]; 4HY_A_3(3D57)[-9.1]; 4HY_A_4(2PIN)[-9.1];
5 H_NR1B1_RARa 882 (s=53) 31 (s=3) ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASNSSSCPTPGGGHLNGYPVPPYAFFFPP--MLGGLSPP----------------------------------------------------------------------------------------------------GALTTLQHQLPVSGYSTPSPATIETQSSS-----------------------SEEIVPSPPSPP--------------------------------PLPRI-------------------------YKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM--VYT-CH-RDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDR--NKKKK--------EVPKPECSES-------------------------------------------------------------------------------------------------------------------------------------------------------YTLTPEVGELIEKV------RKA-HQETFP--------------------------ALCQLGKY----TTNNSSEQR-------------VSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDT----MTFSD-GLTLNRT-QMH-NAGFG-PLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDR--------QDLEQPDRVDMLQEPLLEALKVY--VRKRR----PSRPHMFPKMLMKITD---L-RSISAKGA----------------ERVITLKMEI----PGSMPPLIQEMLEN----------------SEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP---------------------------------------------------- JYI_B_6(4JYI)[-11.9]; 1NY_B_7(4JYG)[-11.5]; EQO_B_5(3KMZ)[-11.5]; JYI_A_5(4JYI)[-11.4]; 1NY_A_5(4JYG)[-11.3];
6 H_NR1B2_RARb 977 (s=131) 32 (s=4) ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTTSGHACPVPAVNGHMTHYPATPYPLLFP--PVIGGLSL----------------------------------------------------------------------------------------------------PPLHGLHGHPPPSGCSTPSPATIETQSTS-----------------------SEELVPSPPSPL--------------------------------PPPRV-------------------------YKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM--IYT-CH-RDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDR--NKKKK--------ETSKQECTES-------------------------------------------------------------------------------------------------------------------------------------------------------YEMTAELDDLTEKI------RKA-HQETFP--------------------------SLCQLGKY----TTNSSADHR-------------VRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDT----MTFSD-GLTLNRT-QMH-NAGFG-PLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDR--------QDLEEPTKVDKLQEPLLEALKIY--IRKRR----PSKPHMFPKILMKITD---L-RSISAKGA----------------ERVITLKMEI----PGSMPPLIQEMLEN----------------SEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ----------------------------------------------------------- JYI_B_6(4JYI)[-11.8]; EQO_B_5(3KMZ)[-11.5]; EQO_A_10(3KMZ)[-11.3]; JYI_A_5(4JYI)[-11.3]; 1NY_A_5(4JYG)[-11.0];
7 H_NR1B3_RARg 905 (s=144) 36 (s=3) ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATNKERLFAAGALGPGSGYPGAGFPFAFP--GALRGSPPFE--------------------------------------------------------------------------------------------------MLSPSFRGLGQPDLPKEMASLSVETQSTS-----------------------SEEMVPSSPSPP--------------------------------PPPRV-------------------------YKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM--VYT-CH-RDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDR--NKKKK--------EVKEEGSPDS-------------------------------------------------------------------------------------------------------------------------------------------------------YELSPQLEELITKV------SKA-HQETFP--------------------------SLCQLGKY----TTNSSADHR-------------VQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDT----MTFSD-GLTLNRT-QMH-NAGFG-PLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDR--------MDLEEPEKVDKLQEPLLEALRLY--ARRRR----PSQPYMFPRMLMKITD---L-RGISTKGA----------------ERAITLKMEI----PGPMPPLIREMLEN----------------PEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA-------------------------------------------------------------- 184_A_2(1FCX)[-11.4]; EQO_B_5(3KMZ)[-11.4]; JYI_B_6(4JYI)[-11.4]; 564_A_2(1FCY)[-11.2]; EQO_A_10(3KMZ)[-11.1];
8 H_NR1C1_PPARa 1302 (s=266) 46 (s=2) --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVDTESPLCPLSPLEAGDLESPLSEE--FLQEMGNIQEISQSIGEDSSGSFGFTEYQY------------------------------------------------------------------------------LGSCPGSDGSVITDTLSPASSPSSVTYPV-----------------------VPGSVDESPSGAL-------------------------------------------------------------NIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKL--VYDKC---DRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGR--MPRSE--------KAKLKAEILT-------------CEHDIEDSET-------------------------------------------------------------------------------------------ADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAE------KTLVAKLVAN-------------------------------GIQ------NKEAEVR-------------------IFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGML----VAYGN-GFITREFLKSL-RKPFC-DIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDR--------PGLLNVGHIEKMQEGIVHVLRLH--LQSNH----PDDIFLFPKLLQKMAD---L-RQLVTEHA----------------QLVQIIKKTE---SDAALHPLLQEIYRD----------------MY------------------------------------------------------------------------------------------------ 471_L_12(1KKQ)[-11.3]; 13M_A_2(3VI8)[-11.2]; S44_A_2(2ZNN)[-11.2]; 13M_A_2(3VI8)[-11.2]; 471_K_11(1KKQ)[-10.8];
9 H_NR1C2_PPARb 1234 (s=185) 38 (s=5) -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEQPQEEAPEVREEEEKEEVAEA--------------------------------------------------------------------------------------------------------------EGAPELNGGPQHALPSSSYTDLSRSSSPP-----------------------SLLDQLQMGCDGA-------------------------------SCGSL-------------------------NMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKL--EYEKC---ERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGR--MPEAE--------KRKLVAGLTA-------------NEGSQYNPQV-------------------------------------------------------------------------------------------ADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAE------KGLVWKQLVN-------------------------------GLP----PYKEISVHV--------------------FYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLL----VANGS-GFVTREFLRSL-RKPFS-DIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDR--------PGLMNVPRVEAIQDTILRALEFH--LQANH----PDAQYLFPKLLQKMAD---L-RQLVTEHA----------------QMMQRIKKTE---TETSLHPLLQEIYKD----------------MY------------------------------------------------------------------------------------------------ 1FA_B_4(2Q5G)[-11.4]; 1FA_A_3(2Q5G)[-11.2]; 3EQ_B_10(3PEQ)[-10.6]; 3EQ_A_3(3PEQ)[-10.4]; 3OZ_A_2(3OZ0)[-10.3];
10 H_NR1C3_PPARg 1422 (s=134) 40 (s=3) ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGETLGDSPIDPESDSFTDTLSANISQE--MTMVDTEMPFWPTNFGISSVDL--------------------------------------------------------------------------------------SVMEDHSHSFDIKPFTTVDFSSISTPHYE----------------------DIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLM-------------------AIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKL--IYDRC---DLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGR--MPQAE--------KEKLLAEISS-------------DIDQLNPESA--------------------------------------------------------------------------------------------DLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGE------DKIKFKHITP--------------------------------LQ----EQSKEVAIR-------------------IFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVL----ISEGQ-GFMTREFLKSL-RKPFG-DFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDR--------PGLLNVKPIEDIQDNLLQALELQ--LKLNH----PESSQLFAKLLQKMTD---L-RQIVTEHV----------------QLLQVIKKTE---TDMSLHPLLQEIYKD----------------LY------------------------------------------------------------------------------------------------ 538_D_6(3KMG)[-12.7]; 538_A_5(3KMG)[-12.6]; 3JX_D_4(4R2U)[-12.5]; 2PQ_A_3(3GBK)[-12.4]; 072_D_8(4PRG)[-12.3];
11 H_NR1D1_REVa 294 (s=0) 46 (s=0) ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTTLDSNNNTGGVITYIGSSGSSPSRTSPE--SLYSDNSNGSFQSLTQGCPT----------------------------------------------------------------------------------------YFPPSPTGSLTQDPARSFGSIPPSLSDDG-----------------------SPSSSSSSSSSSSSFYNGSPPGSLQVAMEDSSRVSPSKSTSNITKLNGM-------------------------VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNI--QYKRCL-KNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGR--IPKRE--------KQRMLAEMQSAMNLANNQLSSQCPLETSPTQHP------------TPGPMGPSPPPAPVPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTLAAQRHNEALNGLRQAPSSYPPTWPPGPAH--HSCHQSNSNGHRLCPTHVYAAPEGKAPANSPRQGNSKNVLLACPMNMY----PHGRSGRTV-----------------QEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQT----VMFLS-RTTYSLQ-ELG-AMGMG-DLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADR--------SGMENSASVEQLQETLLRALRAL--VLKNR----PLETSRFTKLLLKLPD---L-RTLNNMHS----------------EKLLSFRVDAQ----------------------------------------------------------------------------------------------------------------------------------- HEM_A_2(3CQV)[-13.1];
12 H_NR1D2_REVb 448 (s=0) 44 (s=0) -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEVNAGGVIAYISSSSSASSPASCHSEGS--ENSFQSSSSSVPSSPNS-------------------------------------------------------------------------------------------SNSDTNGNPKNGDLANIEGILKNDRIDCS-----------------------MKTSKSSAPGMTK----------SHSGVTKFSGM----------------------------------------VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNI--QYKKCL-KNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGR--IPKRE--------KQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHH-------------------EQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHFPCSESQQHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENKNSYLCNTGGRMHLVCPLSKS----PYVDPHKSG-----------------HEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERT----VTFLS-GKKYSVD-DLH-SMGAG-DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADR--------SGIENVNSVEALQETLIRALRTL--IMKNH----PNEASIFTKLLLKLPD---L-RSLNNMHS----------------EELLAFKVHP------------------------------------------------------------------------------------------------------------------------------------ HEM_A_2(3CQV)[-12.7];
13 H_NR1F1_RORa 1132 (s=36) 39 (s=1) ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNEGAPGDSDLETEARVPWSIMGH--CLRTGQARMSA-------------------------------------------------------------------------------------------------TPTPAGEGARRDELFGILQILHQCILSSG-----------------------DAFVLTGVCCSWR----QNGKPPYSQKEDKEVQTGY--------MNAQIE------------------------IIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNA--TYS-CP-RQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGR--MSKKQ--------RDSLYAEVQK-------------HRMQQQQRDH----------------------------------QQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNI------SKS-HLETCQ--------YLREELQQI------TWQTFLQEEIE----NYQNKQREV-------------------MWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNT----VYFDG-KYASPDV--FK-SLGCE-DFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADR--------SWLQEKVKIEKLQQKIQLALQHV--LQKNH-----REDGILTKLICKVST---L-RALCGRHT----------------EKLMAFKAIYPDIVRLHFPPLYKELFTS----------------EFEPAMQIDG---------------------------------------------------------------------------------------- C3S_B_2(1S0X)[-10.2]; 4D8_A_5(4S15)[-9.0]; ZBD_A_4(4YMQ)[-8.9]; CLR_B_2(1N83)[-8.9]; CLR_B_2(1N83)[-8.9];
14 H_NR1F2_RORb 1184 (s=78) 51 (s=2) -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MCENQLKTKADATAQIE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNA--SYS-CP-RQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGR--MSKKQ--------RDSLYAEVQK-------------HQQRLQEQRQ----------------------------QQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGIKQ----IKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNI------IKS-HLETCQ--------YTMEELHQL------AWQTHTYEEIK----AYQSKSREA-------------------LWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNT----VLFEG-KYGGMQM--FK-ALGSD-DLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDR--------AWLIEPRKVQKLQEKIYFALQHV--IQKNH-----LDDETLAKLIAKIPT---I-TAVCNLHG----------------EKLQVFKQSHPEIVNTLFPPLYKELFNP----------------DCATGCK------------------------------------------------------------------------------------------- C3S_B_2(1S0X)[-9.5]; ZBD_A_4(4YMQ)[-9.0]; 4Q3_C_7(4ZOM)[-8.7]; 4D8_A_5(4S15)[-8.5]; HC3_B_6(3L0L)[-8.3];
15 H_NR1F3_RORg 1324 (s=369) 41 (s=3) --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDRAPQRQHRASRE--------------------------------------------------------------------------------------------------------------LLAAKKTHTSQIE-----------------------------------------------------------------------------------------------------------------VIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNA--AYS-CT-RQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGR--MSKKQ--------RDSLHAEVQK--------QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSV------CKS-YRETCQ--------LRLEDLLRQ------RSNIFSREEVT----GYQRKSMWE-------------------MWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRT----VFFEG-KYGGMEL--FR-ALGCS-ELISSIFDFSHSLSALHFSEDEIALYTALVLINAHR--------PGLQEKRKVEQLQYNLELAFHHHL-CKTHR-----------QSILAKLPPKGKL-RSLCSQHV----------------ERLQIFQHLHPIVVQAAFPPLYKELFST----------------ETESPVGLSK---------------------------------------------------------------------------------------- 43V_A_3(4XT9)[-10.1]; ZBD_A_4(4YMQ)[-9.6]; DGX_B_4(3B0W)[-9.5]; 4Q3_C_7(4ZOM)[-9.5]; NBH_B_7(4NIE)[-9.4];
16 H_NR1H2_LXRb 1102 (s=75) 37 (s=1) ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSPTTSSLDTPLPGNGPPQPGAPSSSP--TVKE--------------------------------------------------------------------------------------------------------EGPEPWPGGPDPDVPGTDEASSACSTDWV-----------------------IPDPEEEPERKRK-----------------------------KGPAPKMLG-----------------------HELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYA-CR-GGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEE--QIRKK--------KIRKQQQQES-------------QSQSQSPVGP---------------------------------------------------------------------------------------------------QGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQL------VAA-QLQCNK-----------------RSFSDQPKVTPWPLGAD----PQSRDARQQ-------------------RFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETEC----ITFLK-DFTYSKD-DFH-RAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADR--------PNVQEPGRVEALQQPYVEALLSY--TRIKR----PQDQLRFPRMLMKLVS---L-RTLSSVHS----------------EQVFALRLQD-----KKLPPLLSEIWDV----------------HE------------------------------------------------------------------------------------------------ LX2_B_6(3FC6)[-13.3]; LX2_D_8(3FC6)[-13.1]; 965_A_3(3IPQ)[-12.6]; 965_A_3(3IPQ)[-12.6]; 965_B_6(1PQ6)[-12.6];
17 H_NR1H3_LXRa 1082 (s=18) 41 (s=0) -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSLWLGAPVPDIPPD--SAVELWKPGAQ-------------------------------------------------------------------------------------------------DASSQAQGGSSCILREEARMPHSAGGTAG-----------------------VGLEAAEPTALLT----RAEPPSEPTEIRPQKRKKG--------PAPKMLG-----------------------NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGA--HYI-CH-SGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEE--QIRLK--------KLKRQEEEQA-------------HATSLPPRAS--------------------------------------------------------------------------------------------------------------------------SPPQILPQLSPEQLGMIEKL------VAA-QQQCNR-----------------RSFSDRLRVTPWPMAPD----PHSREARQQ-------------------RFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSES----ITFLK-DFSYNRE-DFA-KAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADR--------PNVQDQLQVERLQHTYVEALHAY--VSIHH----PHDRLMFPRMLMKLVS---L-RTLSSVHS----------------EQVFALRLQD-----KKLPPLLSEIWDV----------------HE------------------------------------------------------------------------------------------------ LX2_B_6(3FC6)[-13.3]; LX2_D_8(3FC6)[-13.1]; 965_A_3(3IPQ)[-12.6]; 965_A_3(3IPQ)[-12.6]; 965_B_6(1PQ6)[-12.6];
18 H_NR1H4_FXR 1030 (s=41) 37 (s=5) ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYSNVQFP----------------------------------------------------------------------QVQPQISSSSYYSNLGFYPQQPEEWYSPG-----------------------IYELRRMPAETLY----QGETEVAEMPVTKKPRMGA--------SAGRIKG-----------------------DELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNA--VYK-CK-NGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCK--------SKRLRKNVKQ-------------HADQTVNEDS--------------------------------------------------------------------------------------------------------------EGRDLRQVTSTTKSCREKTELTPDQQTLLHFI------MDSYNKQRMP---------------------------QEITNKI----LKEEFSAEE-------------------NFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKK-------LPSGHSDLLEERI---R-NSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDR--------QYIKDREAVEKLQEPLLDVLQKL--CKIHQ----PENPQHFACLLGRLTE---L-RTFNHHHA----------------EMLMSWRVND-----HKFTPLLCEIWDV----------------Q------------------------------------------------------------------------------------------------- 37G_A_5(3RUU)[-12.2]; OOK_A_5(3OOK)[-12.1]; 89P_A_3(3P89)[-12.1]; OOK_C_6(3OOK)[-12.0]; OMM_C_6(3OMM)[-11.9];
19 H_NR1I1_VDR 1005 (s=42) 43 (s=1) --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEAMAASTSLPDPGDFDRNV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKA--LFT-CP-FNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKRE--------MILKRKEEEA-------------LKDSLRPKLS--------------------------------------------------------------------------------------EEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGD------SSSSCSDHCI--------------TSSDMMDSSSFSNLDLSEED----SDDPSVTLE--------------LSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMS----WTCGNQDYKYRVS-DVT-KAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDR--------PGVQDAALIEAIQDRLSNTLQTYIRCRHPP----PGSHLLYAKMIQKLAD---L-RSLNEEHS----------------KQYRCLSFQP--ECSMKLTPLVLEVFGN----------------EIS----------------------------------------------------------------------------------------------- DS4_A_2(3W0Y)[-13.5]; TFY_A_2(4ITF)[-13.2]; VHW_A_2(3VHW)[-13.1]; TEY_A_2(4ITE)[-12.9]; 6DS_A_2(3W0C)[-12.7];
20 H_NR1I2_PXR 1177 (s=274) 49 (s=4) ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEVRPKESWNHADFVHCEDTES---------------------------------------------------------------------------------------------------------------------------VPGKPSVNADEEVGG--------------------------------------------------------------------------------------------------PQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNA--RLR-CPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDE--AVEER--------RALIKRKKSE-------------RTGTQPLGVQ------------------------------------------------------------------------------------GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKW------SQV-RKDLCS-----------------------LKVSLQLRGEDGSVWNYKPPADSG-------------GKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGT----WECGRLSYCLEDT-----AGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDR--------PGVLQHRVVDQLQEQFAITLKSYIECNRPQ----PAHRFLFLKIMAMLTE---L-RSINAQHT----------------QRLLRIQDIH-----PFATPLMQELFGI----------------TGS----------------------------------------------------------------------------------------------- RFP_B_2(1SKX)[-9.3]; 40U_B_6(4S0T)[-8.5]; 444_E_5(2O9I)[-7.5]; SRL_A_5(1NRL)[-7.1];
21 H_NR1I3_CAR 858 (s=42) 38 (s=3) ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASREDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSI--GPT-CP-FAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAE--ALALR--------RAKQAQRRAQ-------------QTPVQLSKEQ------------------------------------------------------------------------------------------------------------------------EELIRTLLGAHTRHMGTMFEQF------VQFRPPAHLF------------------------------IHHQ----PLPTLAPVL------------------PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQN----FLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDR--------PGVTQRDEIDQLQEEMALTLQSYIKGQQRR----PRDRFLYAKLLGLLAE---L-RSINEAYG----------------YQIQHIQGLS------AMMPLLQEICS------------------------------------------------------------------------------------------------------------------- CID_D_11(1XVP)[-9.7]; ATE_C_3(1XNX)[-6.5];
22 H_NR2A1_HNF4a 678 (s=25) 45 (s=4) -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRLSKTLVDMDMADYSAALDPAY--TTLEFENVQVLTM-----------------------------------------------------------------------------------------------GNDTSPSEGTNLNAPNSLGV----------------------------------------------------------------------------------------------------------SALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNH--MYS-CR-FSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNER--DRIST--------RRSSYEDSSL-----------------------------------------------------------------------------------------------------------------------------------------------------------PSINALLQAE------VLS-RQITSP-----------------------------VSGIN----GDIRAKKIA-------------------SIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDV----LLLGN-DYIVPRH-CPE-LAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDA--------KGLSDPGKIKRLRSQVQVSLEDY--INDRQ----YDSRGRFGELLLLLPT---L-QSITWQMI----------------EQIQFIKLFG----MAKIDNLLQEMLLG----------------GSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI MYR_A_3(3FS1)[-6.6]; MYR_C_3(1PZL)[-6.4]; MYR_C_3(1PZL)[-6.4]; PLM_B_2(1LV2)[-5.6]; DAO_F_6(1M7W)[-5.4];
23 H_NR2A2_HNF4g 693 (s=49) 48 (s=2) --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNTTDNGV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSH--VYS-CR-FSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNER--DRIST--------RRSTFDGSNI-----------------------------------------------------------------------------------------------------------------------------------------------------------PSINTLAQAE------VRSRQISVSS------------------------------PGSS----TDINVKKIA-------------------SIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMYKDI----LLLGN-NYVIHRN-SCE-V-EISRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDPDA--------KGLSDPVKIKNMRFQVQIGLEDY--INDRQ----YDSRGRFGELLLLLPT---L-QSITWQMI----------------EQIQFVKLFG----MVKIDNLLQEMLLG----------------GASNDGSHLHHPMHPHLSQDPLTGQTILLGPMSTLVHADQI----------STPETPLPSPPQGSGQEQYKIAANQA-------SVISHQHLSKQKQL PLM_B_2(1LV2)[-6.6]; MYR_C_3(1PZL)[-6.1]; MYR_C_3(1PZL)[-6.1]; MYR_A_3(3FS1)[-5.3]; DAO_E_5(1M7W)[-5.2];
24 H_NR2B1_RXRa 789 (s=24) 41 (s=1) --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPS--LHPSLGPGIGSPGQLHSPISTLSSPIN---------------------------------------------------------------------------------GMGPPFSVISSPMGPHSMSVPTTPTLGFS-----------------------TGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAH----------PSGNMASFT---------------------KHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDL--TYT-CR-DNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEER--QRGKD--------RNENEVESTS------------------------------------------------------------------------------------------------------------------------------------------------------SANEDMPVERILEAE------LAVEPKTETY--------------------------VEANMGLN----PSSPNDPVT----------------------NICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDG----ILLAT-GLHVHRN-SAH-SAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDS--------KGLSNPAEVEALREKVYASLEAY--CKHKY----PEQPGRFAKLLLRLPA---L-RSIGLKCL----------------EHLFFFKLIG----DTPIDTFLMEMLEA----------------PHQMT--------------------------------------------------------------------------------------------- 5TN_A_3(2P1V)[-10.3]; BM6_E_5(1MVC)[-10.2]; 4TN_A_3(2P1U)[-10.0]; BM6_K_11(1MZN)[-9.9]; BM6_I_9(1MZN)[-9.8];
25 H_NR2B2_RXRb 793 (s=48) 41 (s=1) -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQTPEPEPGEAGRDGMGDSGRDSRSPDSSSPN--PLPQGVPPPSPPGPPLPPSTAPSLGGSGAPPPP---------------------------------------------------------------------------PMPPPPLGSPFPVISSSMGSPGLPPPAPP----------------------GFSGPVSSPQINST----VSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAG---------------------KRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDL--TYS-CR-DNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEER--QRGKD--------KDGDGEGAGG-------------------------------------------------------------------------------------------------------------------------------------------------------APEEMPVDRILEAE------LAVEQKSDQG---------------------------VEGPGGT----GGSGSSPND-------------------PVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDG----ILLAT-GLHVHRN-SAH-SAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDA--------KGLSNPSEVEVLREKVYASLETY--CKQKY----PEQQGRFAKLLLRLPA---L-RSIGLKCL----------------EHLFFFKLIG----DTPIDTFLMEMLEA----------------PHQLA--------------------------------------------------------------------------------------------- 5TN_A_3(2P1V)[-10.3]; BM6_E_5(1MVC)[-10.2]; 4TN_A_3(2P1U)[-10.0]; BM6_K_11(1MZN)[-9.9]; BM6_J_10(1MZN)[-9.8];
26 H_NR2B3_RXRg 786 (s=42) 41 (s=1) ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSA--ALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPY---------------------------------------------------------------------RVITSAMGPPSGALAAPPGINLVAPPSSQ-----------------------LNVVNSVSSSEDI----KPLPGLPGIGNMNYPST----------SPGSLV------------------------KHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDL--IYT-CR-DNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEER--QRSRE--------RAESEAECAT------------------------------------------------------------------------------------------------------------------------------------------------------SGHEDMPVERILEAE------LAVEPKTESY-------------------------------GDM----NMENSTNDP--------------------VTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDG----ILLAT-GLHVHRS-SAH-SAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDA--------KGLSNPSEVETLREKVYATLEAY--TKQKY----PEQPGRFAKLLLRLPA---L-RSIGLKCL----------------EHLFFFKLIG----DTPIDTFLMEMLET----------------PLQIT--------------------------------------------------------------------------------------------- BM6_E_5(1MVC)[-10.2]; 5TN_A_3(2P1V)[-10.2]; 4TN_A_3(2P1U)[-10.0]; BM6_K_11(1MZN)[-9.9]; L79_E_5(1RDT)[-9.8];
27 H_NR2C1_TR2
28 H_NR2C2_TR4
29 H_NR2E1_TLX
30 H_NR2E3_PNR
31 H_NR2F1_COT1
32 H_NR2F2_COT2
33 H_NR2F6_EAR2
34 H_NR3A1_ESRa 853 (s=72) 55 (s=3) ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSK--PAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAA---------------------------------------------------------------------AFGSNGLGGFPPLNSVSPSPLMLLHPPPQ--------------LSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKE------------------TRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHN--DYM-CP-ATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLK--------HKRQRDDGEG-------------RGEVGSAGDM-------------------------------------------------------------------------------------------------------------RAANLWPSPLMIKRSKKNSLALSLTADQMVSAL------LDA-EPPILY------------------------------SEYD----PTRPFSEAS-------------------MMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGK----LLFAP-NLLLDRN-QGKCVEGMV-EIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIH---LMAKAGLTLQQQHQRLAQLLLILSH---I-RHMSNKGM----------------EHLYSMKCKN----VVPLYDLLLEMLDA----------------HRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV------------------------------------------------- IOG_A_2(2IOG)[-11.6]; EZT_A_5(2P15)[-11.5]; EZT_B_6(2P15)[-11.3]; AIU_C_3(1XP6)[-11.3]; AIT_C_3(1XPC)[-11.0];
35 H_NR3A2_ESRb 1119 (s=267) 49 (s=1) --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDIKNSPSSLNSPSSYNCSQSILPLE--HGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNL---------------------------------------------------------------------EGGPGRQTTSPNVLWPTPGHLSPLVVHRQ-----------------------LSHLYAEPQKSPW----CEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRD-------------------AHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHN--DYI-CP-ATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVR--------RQRSADEQLH-------------CAGKAKRSGG------------------------------------------------------------------------------------------------------------------------HAPRVRELLLDALSPEQLVLTL------LEAEPPHVLI--------------------------------SR----PSAPFTEAS-------------------MMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGK----LIFAP-DLVLDRD-EGKCVEGIL-EIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPL----VTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSH---V-RHASNKGM----------------EHLLNMKCKN----VVPVYDLLLEMLNA----------------HVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ----------------------------------------------------------------- AOE_A_2(1HJ1)[-11.6]; EZT_B_6(2P15)[-11.4]; IOG_A_2(2IOG)[-11.3]; AIU_C_3(1XP6)[-11.0]; AIH_C_3(1XP1)[-10.9];
36 H_NR3B1_ERRa 808 (s=150) 60 (s=6) --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSQVVGIEPLYIKAEPASPDSPKGS--SETETEPPVAL-------------------------------------------------------------------------------------------------APGPAPTRCLPGHKEEEDGEGAGPGEQGG-----------------------GKLVLSSLP-----------------------------------------------------------------KRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSI--EYS-CP-ASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDR--VRGGR--------QKYKRRPEVD-------------PLPFPGPFPA-----------------------------------------------------------------------------------------------------------------------GPLAVAGGPRKTAAPVNALVSHL------LVV-EPEKLY------------------------------AMPD----PAGPDGHLP-------------------AVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDE----LAFAE-DLVLDEE-GAR-AAGLG-ELGAALLQLVRRLQALRLEREEYVLLKALALANSDS--------VHIEDAEAVEQLREALHEALLEY--EAGRAGPGGGAERRRAGRLLLTLPL---L-RQTAGKVL----------------AHFYGVKLEG----KVPMHKLFLEMLEA----------------MMD----------------------------------------------------------------------------------------------- 047_A_3(2PJL)[-9.4]; 047_B_4(2PJL)[-9.3]; TXF_B_7(2EWP)[-9.1]; TXF_C_8(2EWP)[-8.8]; BPZ_A_2(2ZKC)[-8.4];
37 H_NR3B2_ERRb 835 (s=151) 51 (s=2) -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSDDRHLGSSCGSFIKTEPSSPSSGI--DALSHHSP----------------------------------------------------------------------------------------------------SGSSDASGGFGLALGTHANGLDSPPMFAG------------------------AGLGGTPCRKSY------EDCASGIMEDSAIKCEY--------MLNAIP------------------------KRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNI--EYS-CP-ATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDR--VRGGR--------QKYKRRLDSE-------------SSPYLSLQIS--------------------------------------------------------------------------------------------------------------------------------PPAKKPLTKIVSYL------LVA-EPDKLY------------------------------AMPP----PGMPEGDIK-------------------ALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDK----LVYAE-DYIMDEE-HSR-LAGLL-ELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDS--------MYIEDLEAVQKLQDLLHEALQDY--ELSQR----HEEPWRTGKLLLTLPL---L-RQTAAKAV----------------QHFYSVKLQG----KVPMHKLFLEMLEAKAWARADSLQEWRPLEQVPSPLHRATKRQHVHFLTPLPPPPSVAWVGTAQAGYHLEVFLPQRAGWPRAA--------------------------------------------- OHT_A_2(2GPU)[-8.7]; 047_A_3(2PJL)[-8.6]; 047_B_4(2PJL)[-8.6]; TXF_C_8(2EWP)[-7.8]; OHT_C_3(1VJB)[-7.7];
38 H_NR3B3_ERRg 793 (s=55) 45 (s=0) -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDSVELCLPESFSLHYEEELLCRMSNK--DRHIDSSCSSFIKTEPSSPASLTDSVNHHSP-----------------------------------------------------------------------------GGSSDASGSYSSTMNGHQNGLDSPPLYPS-----------------------APILGGSGPVRKL-----YDDCSSTIVEDPQTKCEY--------MLNSMP------------------------KRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNI--EYS-CP-ATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDR--VRGGR--------QKYKRRIDAE-------------NSPYLNPQLV--------------------------------------------------------------------------------------------------------------------------------QPAKKPYNKIVSHL------LVA-EPEKIY------------------------------AMPD----PTVPDSDIK-------------------ALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDE----LVYAD-DYIMDED-QSK-LAGLL-DLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDS--------MHIEDVEAVQKLQDVLHEALQDY--EAGQH----MEDPRRAGKMLMTLPL---L-RQTSTKAV----------------QHFYNIKLEG----KVPMHKLFLEMLEA----------------KV------------------------------------------------------------------------------------------------ TXF_C_8(2EWP)[-9.0]; TXF_B_7(2EWP)[-9.0]; TXF_D_9(2EWP)[-8.9]; OHT_A_2(2GPU)[-8.7]; TXF_E_10(2EWP)[-8.6];
39 H_NR3C1_GCR 967 (s=150) 52 (s=5) MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPW--RSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPI-----------------------FNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPP-------PKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQH--NYL-CA-GRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKK-IKGIQ--------QATTGVSQET-------------SENPGNKTIV--------------------------------------------------------------------------------------------------------------------------------PATLPQLTPTLVSL------LEVIEPEVLY------------------------------AGYD----SSVPDSTWR-------------------IMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSA--NLLCFAP-DLIINEQ-RMT-LPCMY-DQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVP-------KDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHE---VVENLLNYCF----------------QTFLDKTMSI------EFPEMLAEIITN----------------QIPKYSNGNIKKLLFHQK-------------------------------------------------------------------------------- JZN_B_8(3K23)[-11.6]; A2K_B_5(4APU)[-11.3]; ENM_A_3(2PNU)[-10.4]; DAY_A_3(3BQD)[-10.3]; NN7_A_4(4CSJ)[-10.1];
40 H_NR3C2_MCR 972 (s=203) 57 (s=3) -----METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNSTQGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYEQQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAIVKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPNAENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVPSPDTQEKGAQEVPFPKTEEVESA--ISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRP------------------SKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQH--NYL-CA-GRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKK--LGKLK--------GIHEEQPQQQ-------------QPPPPPPPPQ-------------------------------------------------------------------------------------------------------SPEEGTTYIAPAKEPSVNTALVPQLSTISRALTPSPVMV------LENIEPEIVY--------A----------------------GYD----SSKPDTAEN-------------------LLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNS--QFLYFAP-DLVFNEE-KMH-QSAMY-ELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIP-------KDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHD---LVSDLLEFCF----------------YTFRESHALK-----VEFPAMLVEIISD----------------QLPKVESGNAKPLYFHRK-------------------------------------------------------------------------------- A2K_B_5(4APU)[-11.2]; JZN_C_9(3K23)[-10.7]; ENM_A_3(2PNU)[-9.7]; SNL_A_2(3VHU)[-9.5]; JZN_B_8(3K23)[-9.5];
41 H_NR3C3_PRGR 967 (s=168) 57 (s=6) --MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPG---RSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPP--ALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKA--------------------------EGAPPQQGPFAPPPCKAPGASGCLLPRDG-----------------------LPSTSASAAAAGA-----APALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQH--NYL-CA-GRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKK--FNKVR--------VVRALDAVAL-------------PQPVGVPNES---------------------------------------------------------------------------------------------------------------------QALSQRFTFSPGQDIQLIPPLINLL------MSI-EPDVIY------------------------------AGHD----NTKPDTSSS-------------------LLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSG--QMLYFAP-DLILNEQ-RMK-ESSFY-SLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIP-------LEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHD---LVKQLHLYCL----------------NTFIQSRALS-----VEFPEMMSEVIAA----------------QLPKILAGMVKPLLFHKK-------------------------------------------------------------------------------- A2K_B_5(4APU)[-12.0]; MOF_A_4(1SR7)[-10.6]; ENM_A_3(2PNU)[-10.2]; JZN_C_9(3K23)[-10.2]; JZN_B_8(3K23)[-10.2];
42 H_NR3C4_ANDR 1086 (s=139) 58 (s=2) ------MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQSRDYYNFPLALAGPPPPPPPPHPH--ARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGPGSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGG----------------------------------GGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFPP---------------------------QKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQ--KYL-CA-SRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKK-----LG--------NLKLQEEGEA-------------SSTTSPTEET-------------------------------------------------------------------------------------------------------------------------TQKLTVSHIEGYECQPIFLNV------LEAIEPGVVC------------------------------AGHD----NNQPDSFAA-------------------LLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNS--RMLYFAP-DLVFNEY-RMH-KSRMY-SQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIP-------VDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQP---IARELHQFTF----------------DLLIKSHMVS-----VDFPEMMAEIISV----------------QVPKILSGKVKPIYFHTQ-------------------------------------------------------------------------------- A2K_B_5(4APU)[-11.5]; ENM_A_3(2PNU)[-10.9]; JZN_A_7(3K23)[-9.9]; 486_B_2(1NHZ)[-9.8]; JZN_C_9(3K23)[-9.7];
43 H_NR4A1_NGFIB
44 H_NR4A2_NURR1
45 H_NR4A3_NOR1
46 H_NR5A1_STF1 2064 (s=219) 47 (s=1) -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDYSYDEDL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNK--HYT-CT-ESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADR--MRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPP-----------------------------------------------------------------------------------PAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPLAGYLYPAFPGRA------IKSEYPEPYA--SPPQPGLPYGYPEPFSGGPNVPELILQLLQLE----PDEDQVRAR--ILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQ-EVELTTV-ATQ-AGSLLHSLVLRAQELVLQLLALQLDRQEFVCLKFIILFSLDL--------KFLNNHILVKDAQEKANAALLDY--TLCHY----PHCGDKFQQLLLCLVE---V-RALSMQAK----------------EYLYHKHLGN----EMPRNNLLIEMLQA----------------KQT----------------------------------------------------------------------------------------------- PEF_F_6(1ZDT)[-11.2]; EPH_B_5(4DOR)[-11.0]; PEF_C_3(1YP0)[-10.7]; P3A_D_4(1ZDU)[-10.4]; P0E_C_3(1YOW)[-10.2];
47 H_NR5A2_LRH1 1785 (s=149) 37 (s=2) ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPAR--GRLVMLPKVETE------------------------------------------------------------------------------------------------ALGLARSHGEQGQMPENMQVSQFKMVNYS-----------------------YDEDL---------------------------------------------------------------------EELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNK--RYT-CI-ENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADR--MRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSD--------------------------------------------------------------------------------LTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRA------IKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCE----PDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQ-QVDYSII-ASQ-AGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDV--------KNLENFQLVEGVQEQVNAALLDY--TMCNY----PQQTEKFGQLLLRLPE---I-RAISMQAE----------------EYLYYKHLNG----DVPYNNLLIEMLHA----------------KRA----------------------------------------------------------------------------------------------- P3A_D_4(1ZDU)[-12.1]; P6L_D_4(1YOK)[-11.6]; EPH_B_5(4DOR)[-11.4]; PEF_C_3(1YP0)[-11.3]; PEF_F_6(1ZDT)[-11.2];
48 H_NR6A1_GCN1