@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GTR6_HUMAN: (2018-03-06 )
MQEPLLGAEGPDYDTFPEKPPPSPGDRARVGTLQNKRVFLATFAAVLGNFSFGYALVYTSPVIPALERSLDPDLHLTKSQASWFGSVFTLGAAAGGLSAMILNDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRTLTGFAGGLTAACIPVYVSEIAPPGVRGALGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEAPVLIMILLLSFMPNSPRFLLSRGRDEEALRALAWLRGTDVDVHWEFEQIQDNVRRQSSRVSWAEARAPHVCRPITVALLMRLLQQLTGITPILVYLQSIFDSTAVLLPPKDDAAIVGAVRLLSVLIAALTMDLAGRKVLLFVSAAIMFAANLTLGLYIHFGPRPLSPNSTAGLESESWGDLAQPLAAPAGYLTLVPLLATMLFIMGYAVGWGPITWLLMSEVLPLRARGVASGLCVLASWLTAFVLTKSFLPVVSTFGLQVPFFFFAAICLVSLVFTGCCVPETKGRSLEQIESFFRTGRRSFLR
Atome Classification :
(15 SA)
.........10........20........30........40........50........60........70---.--------------.----------..----------...--------------..80-....----------------....---90........100.......110.......120.....------------------.------------------.---130-...-----------------------......140.......150.......160.......170.......180--.......------190----------..------------.......200.......210.......220-..-...-..230.......240...--....250..--.--..--..260.....-.-.270.......280.......290.......300.....-.-.310....-----...320.......330.......340...-....350..-.....360.......370.......380.......390.......400.......410.......420.......430.......440.......450..------.-------.------...460.......470.......480.......490.......500.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQEPLLGAEGPDYDTFPEKPPPSPGDR
A
R
V
GTLQNKR
V
F
L
A
T
F
A
A
V
LGNFSF
G
Y
A
L
V
YTS
P
V
I
P
A
L
E
R
SL----D--------------P----------D
L
----------
H
L
T
--------------
K
S
Q
A
-
S
W
F
G
----------------
S
V
F
T
---
L
GAAAG
G
L
S
A
M
I
L
N
D
L
LG
R
K
L
S
I
M
FSAVPSAA
G
Y
A
L
M
A------------------G------------------
A
---
H
---
G
L
W
-----------------------
M
L
L
L
G
R
T
L
T
GFAGG
L
T
A
A
C
I
P
V
Y
V
S
EIAPPGVRGALGA
T
P
Q
L
M
A
V
F
G
S
L
--
S
L
Y
A
L
G
L
------L------------L
P
------------
W
R
W
LAVAGE
A
P
V
L
I
M
I
L
L
L
S
FMPNS
P
R
F
L
L
-SR-GR
D
-
E
E
A
L
R
A
L
A
W
LRGT
D
V
D
V
H
--
W
E
F
E
Q
I
Q
D
N
--
V
--
R
R
--
Q
SSRVS
W
A
EA-R-APHVC
R
P
I
T
V
A
L
L
M
R
L
L
Q
Q
L
TG
I
T
P
I
L
V
Y
L
Q
S
I
FDS
T
A
V
-
L
-LPPKD
D
A
A
-----
I
V
G
A
V
R
L
L
S
V
L
I
A
A
L
T
M
DLAG
R
K
V
L
L
F
V
S
-
A
A
I
M
F
AAN
L
-
T
L
G
L
Y
I
H
FGPRPLSPNSTAGLESE
S
W
G
D
L
A
Q
P
L
AAPA
G
Y
L
T
L
V
P
L
L
A
T
M
L
F
I
M
G
YAV
G
W
G
P
I
T
W
L
L
M
S
E
VL
P
L
RAR
G
V
A
S
G
L
C
V
L
A
S
W
L
T
A
F
V
L
T
K
S
F
L
P
------
V
-------
V
------
S
TFGLQ
V
P
F
F
F
F
A
A
I
C
L
V
S
L
V
FTGCCVPETKGR
S
L
E
Q
I
E
S
F
F
R
T
G
R
R
S
FLR
3
PsiBlast_PDB
81.39
28%
-107
- C4 -
-
5EQG
1
GTR1_HUMAN
A:
[11-455]
------------------------------------
R
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
----
N
T
G
V
I
N
A
P
Q
K
V
I
----
E
--------------
E
----------
F
Y
----------
N
Q
T
W
V
H
R
YGESIL
P
T
T
L
T
T
L
W
-
S
L
S
V
----------------
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
------------------
F
------------------
S
---
K
LGK
S
F
E
-----------------------
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
--
I
A
Q
V
F
G
L
DSIMGN
K
------------
D
L
------------
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
N
E
E
-
N
R
A
K
S
V
L
K
K
L
R
G
T
-
A
D
V
T
--
H
D
L
Q
E
M
K
E
E
--
S
--
R
Q
M
M
R
E
K
K
V
T
I
L
E
L
F
R
-
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
-
Q
-
Q
P
V
Y
A
T
I
G
------
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
E
R
A
G
R
R
T
L
H
L
I
G
-
L
A
G
M
A
G
C
A
I
-
L
M
T
I
------------
A
L
A
L
L
E
Q
L
P
W
----------
M
S
Y
L
S
I
V
A
I
F
G
---
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
------
V
-------
E
------
Q
L
C
G
P
Y
V
-
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
---------------------
21
HHSearch
81.38
28%
-106
- C4 -
-
5EQG
1
GTR1_HUMAN
A:
[9-455]
----------------------------------
T
G
R
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
F
Y
----
N
--------------
Q
----------
T
W
V
H
R
YGESIL
P
T
T
L
--------------
T
T
L
W
-
S
L
S
V
----------------
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
------------------
F
------------------
S
KLG
K
---
S
F
E
-----------------------
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
--
I
A
Q
V
F
G
L
DSIMGN
K
------------
D
L
------------
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
N
E
E
-
N
R
A
K
S
V
L
K
K
L
R
G
T
A
D
V
T
H
---
D
L
Q
E
M
K
E
E
--
S
R
Q
M
M
--
R
E
K
K
V
T
I
L
E
L
-
F
R
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
---
Q
Q
P
V
Y
A
T
I
-----
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
E
R
A
G
R
R
T
L
H
L
I
G
-
L
A
G
M
A
G
C
A
I
-
L
M
T
I
A
L
A
L
L
E
Q
------------------------
L
P
-
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
------
V
-------
E
------
Q
L
C
G
P
Y
-
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
---------------------
4
PsiBlast_PDB
80.73
28%
-107
- C4 -
-
5EQH
1
GTR1_HUMAN
A:
[11-455]
------------------------------------
R
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
----
N
T
G
V
I
N
A
P
Q
K
V
I
----
E
--------------
E
----------
F
Y
----------
N
Q
T
W
V
H
R
YGESIL
P
T
T
L
T
T
L
W
-
S
L
S
V
----------------
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
------------------
F
------------------
S
---
K
LGK
S
F
E
-----------------------
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
--
I
A
Q
V
F
G
L
DSIMGN
K
------------
D
L
------------
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
N
E
E
-
N
R
A
K
S
V
L
K
K
L
R
G
T
-
A
D
V
T
--
H
D
L
Q
E
M
K
E
E
--
S
--
R
Q
M
M
R
E
K
K
V
T
I
L
E
L
F
R
-
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
-
Q
-
Q
P
V
Y
A
T
I
G
------
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
E
R
A
G
R
R
T
L
H
L
I
G
-
L
A
G
M
A
G
C
A
I
-
L
M
T
I
------------
A
L
A
L
L
E
Q
L
P
W
----------
M
S
Y
L
S
I
V
A
I
F
G
---
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
------
V
-------
E
------
Q
L
C
G
P
Y
V
-
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
---------------------
5
PsiBlast_PDB
79.70
28%
-106
- C4 -
-
5EQI
1
GTR1_HUMAN
A:
[11-455]
------------------------------------
R
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
----
N
T
G
V
I
N
A
P
Q
K
V
I
----
E
--------------
E
----------
F
Y
----------
N
Q
T
W
V
H
R
YGESIL
P
T
T
L
T
T
L
W
-
S
L
S
V
----------------
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
------------------
F
------------------
S
---
K
LGK
S
F
E
-----------------------
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
--
I
A
Q
V
F
G
L
DSIMGN
K
------------
D
L
------------
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
N
E
E
-
N
R
A
K
S
V
L
K
K
L
R
G
T
-
A
D
V
T
--
H
D
L
Q
E
M
K
E
E
--
S
--
R
Q
M
M
R
E
K
K
V
T
I
L
E
L
F
R
-
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
-
Q
-
Q
P
V
Y
A
T
I
G
------
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
E
R
A
G
R
R
T
L
H
L
I
G
-
L
A
G
M
A
G
C
A
I
-
L
M
T
I
------------
A
L
A
L
L
E
Q
L
P
W
----------
M
S
Y
L
S
I
V
A
I
F
G
---
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
------
V
-------
E
------
Q
L
C
G
P
Y
V
-
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
---------------------
43
Fugue
78.81
25%
-138
- C4 -
-
4GC0
5
XYLE_ECOLI
A:
[5-479]
--------------------------------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
VAPQ
N
--------------
L
----------
S
E
----------
S
A
A
--------------
N
S
L
L
-
G
F
C
V
----------------
A
S
A
L
---
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
------------------
W
PELGFTSINPDNTVPVYL
A
---
G
---
Y
V
P
-----------------------
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
--
L
V
Y
C
V
N
Y
------
F
------------
I
A
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
Q
-
E
Q
A
E
G
I
L
R
K
I
M
G
-
N
T
L
A
T
--
Q
A
V
Q
E
I
K
H
S
--
L
--
D
H
--
G
R
K
T
G
G
R
L
L
M
-
F
-
G
V
G
---
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
-
D
I
A
L
L
Q
T
I
-----
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
A
I
G
M
F
-
S
L
G
T
A
F
Y
T
Q
A
P
-----------------------------
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
-------
V
------
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--------
10
PsiBlast_PDB
78.71
24%
-118
- C4 -
-
4GC0
5
XYLE_ECOLI
A:
[6-479]
---------------------------------
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
----
V
--------------
A
----------
P
Q
----------
N
L
S
--------------
E
S
A
A
N
S
L
L
G
----------------
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
-----
L
F
F
I
S
------------------
G
------------------
V
---
G
---
S
A
W
PELGFTSINPDNTVPVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
--
L
V
Y
C
V
N
Y
------
F
------------
I
A
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
Q
-
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
--
G
--
R
K
--
T
G
G
R
L
L
M
F
G
V
-
G
-
V
------
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
------
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
A
I
G
M
F
-
S
L
G
T
A
F
Y
-------------------------
T
Q
A
P
G
----
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
-
P
------
M
M
D
K
N
S
W
L
V
------
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--------
8
PsiBlast_PDB
78.54
24%
-116
- C4 -
-
4GBY
5
XYLE_ECOLI
A:
[6-479]
---------------------------------
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
----
V
--------------
A
----------
P
Q
----------
N
L
S
--------------
E
S
A
A
N
S
L
L
G
----------------
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
-----
L
F
F
I
S
------------------
G
------------------
V
---
G
---
S
A
W
PELGFTSINPDNTVPVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
--
L
V
Y
C
V
N
Y
------
F
------------
I
A
R
SGD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
Q
-
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
--
G
--
R
K
--
T
G
G
R
L
L
M
F
G
V
-
G
-
V
------
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
------
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
A
I
G
M
F
-
S
L
G
T
A
F
Y
-------------------------
T
Q
A
P
G
----
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
-
P
------
M
M
D
K
N
S
W
L
V
------
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--------
23
HHSearch
78.46
26%
-139
- C4 -
-
4GBY
5
XYLE_ECOLI
A:
[7-476]
----------------------------------
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
----
V
--------------
A
PQNL------
S
E
----------
S
A
A
--------------
N
S
L
L
-
G
F
C
V
----------------
A
S
A
L
---
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
WPELGFTSINPDNTVPVY
L
------------------
A
---
G
---
Y
V
P
-----------------------
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
--
L
V
Y
C
V
N
Y
------
F
I
A
R
SGD
A
S
W
L
N
T
D
G
------------
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
Q
-
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
---
Q
A
V
Q
E
I
K
H
S
--
L
--
D
H
----
G
R
K
T
G
G
R
L
-
L
-
M
-
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
-
S
T
D
I
A
L
L
Q
T
I
-----
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
A
I
G
M
F
-
S
L
G
T
A
F
Y
T
Q
A
-----------------------------
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
------
M
-------
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
-----------
22
HHSearch
78.34
26%
-138
- C4 -
-
4GC0
5
XYLE_ECOLI
A:
[7-476]
----------------------------------
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
----
V
--------------
A
PQNL------
S
E
----------
S
A
A
--------------
N
S
L
L
-
G
F
C
V
----------------
A
S
A
L
---
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
WPELGFTSINPDNTVPVY
L
------------------
A
---
G
---
Y
V
P
-----------------------
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
--
L
V
Y
C
V
N
Y
------
F
I
A
R
S
GD
A
S
W
L
N
T
D
G
------------
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
Q
-
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
---
Q
A
V
Q
E
I
K
H
S
--
L
--
D
H
----
G
R
K
T
G
G
R
L
-
L
-
M
-
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
-
S
T
D
I
A
L
L
Q
T
I
-----
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
A
I
G
M
F
-
S
L
G
T
A
F
Y
T
Q
A
-----------------------------
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
------
M
-------
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
-----------
2
PsiBlast_PDB
78.04
28%
-107
- C4 -
-
4PYP
1
GTR1_HUMAN
A:
[11-455]
------------------------------------
R
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
----
N
T
G
V
I
N
A
P
Q
K
V
I
----
E
--------------
E
----------------------
F
Y
T
--------------
Q
T
W
V
-
H
R
Y
G
E
S
I
L
P
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
------------------
F
------------------
S
---
K
LGK
S
F
E
-----------------------
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
--
I
A
Q
V
F
G
L
DSIMGN
K
------------
D
L
------------
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
N
E
E
-
N
R
A
K
S
V
L
K
K
L
R
G
T
-
A
D
V
T
--
H
D
L
Q
E
M
K
E
E
--
S
--
R
Q
MM
R
E
K
K
V
T
I
L
E
L
F
R
-
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
-
Q
-
Q
P
V
Y
A
T
I
G
------
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
-
L
A
G
M
A
G
C
A
I
-
L
M
T
I
------------
A
L
A
L
L
E
Q
L
P
W
----------
M
S
Y
L
S
I
V
A
I
F
G
---
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
------
V
-------
E
------
Q
L
C
G
P
Y
V
-
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
---------------------
9
PsiBlast_PDB
77.42
24%
-117
- C4 -
-
4GBZ
5
XYLE_ECOLI
A:
[6-479]
---------------------------------
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
----
V
--------------
A
----------
P
Q
----------
N
L
S
--------------
E
S
A
A
N
S
L
L
G
----------------
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
-----
L
F
F
I
S
------------------
G
------------------
V
---
G
---
S
A
W
PELGFTSINPDNTVPVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
--
L
V
Y
C
V
N
Y
------
F
------------
I
A
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
Q
-
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
--
G
--
R
K
--
T
G
G
R
L
L
M
F
G
V
-
G
-
V
------
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
------
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
A
I
G
M
F
-
S
L
G
T
A
F
Y
-------------------------
T
Q
A
P
G
----
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
-
P
------
M
M
D
K
N
S
W
L
V
------
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--------
24
HHSearch
76.17
26%
-101
- C4 -
-
4ZW9
4
GTR3_HUMAN
A:
[26-481]
-------------------------------
Q
K
V
T
P
A
L
I
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
----
T
--------------
K
T
L
T
D
K
GNAPP
S
E
----------
V
L
L
--------------
T
S
L
W
-
S
L
S
V
----------------
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
CK---------------
V
------------------
A
---
K
---
S
V
E
-----------------------
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
--
V
A
Q
I
F
G
L
EFILGS
E
------------
E
L
------------
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
-
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
---
Q
D
I
Q
E
M
K
D
E
S
A
R
--
M
S
--
Q
E
K
Q
V
T
V
L
E
L
-
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
---
Q
E
P
I
Y
A
T
I
-----
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
-
L
G
G
M
A
F
C
S
T
-
L
M
T
V
S
L
L
L
K
D
N
------------------------
Y
N
-
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
-------
A
------
H
Y
L
G
A
Y
-
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
---------------
13
PsiBlast_PDB
75.69
26%
-105
- C4 -
-
4ZW9
4
GTR3_HUMAN
A:
[34-488]
---------------------------------------
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
----
N
T
G
V
I
N
A
P
E
K
I
I
----
K
E
F
I
T
K
T
L
T
D
K
GNAP
P
----------
S
E
----------
V
L
L
--------------
T
S
L
W
-
S
L
S
V
----------------
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
CK---------------
V
------------------
A
---
K
---
S
V
E
-----------------------
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
------
I
------------
L
G
SEEL--------
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
K
E
E
-
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
-
D
V
S
--
Q
D
I
Q
E
M
K
D
E
--
S
--
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
-
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
-
Q
-
E
P
I
Y
A
T
I
G
------
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
-------
L
K
D
N
Y
N
G
--------------------
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
-------
A
------
H
Y
L
G
A
Y
V
-
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
--------
14
PsiBlast_PDB
74.08
26%
-104
- C4 -
-
4ZWB
1
GTR3_HUMAN
A:
[34-488]
---------------------------------------
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
----
N
T
G
V
I
N
A
P
E
K
I
I
----
K
E
F
I
T
K
T
L
T
D
K
GNAP
P
----------
S
E
----------
V
L
L
--------------
T
S
L
W
-
S
L
S
V
----------------
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
CK---------------
V
------------------
A
---
K
---
S
V
E
-----------------------
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
------
I
------------
L
G
SEEL--------
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
K
E
E
-
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
-
D
V
S
--
Q
D
I
Q
E
M
K
D
E
--
S
--
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
-
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
-
Q
-
E
P
I
Y
A
T
I
G
------
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
-------
L
K
D
N
Y
N
G
--------------------
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
-------
A
------
H
Y
L
G
A
Y
V
-
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
--------
15
PsiBlast_PDB
73.14
26%
-102
- C4 -
-
4ZWC
3
GTR3_HUMAN
A:
[34-488]
---------------------------------------
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
----
N
T
G
V
I
N
A
P
E
K
I
I
----
K
E
F
I
T
K
T
L
T
D
K
GNAP
P
----------
S
E
----------
V
L
L
--------------
T
S
L
W
-
S
L
S
V
----------------
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
CK---------------
V
------------------
A
---
K
---
S
V
E
-----------------------
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
------
I
------------
L
G
SEEL--------
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
K
E
E
-
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
-
D
V
S
--
Q
D
I
Q
E
M
K
D
E
--
S
--
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
-
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
-
Q
-
E
P
I
Y
A
T
I
G
------
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
-------
L
K
D
N
Y
N
G
--------------------
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
-------
A
------
H
Y
L
G
A
Y
V
-
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
--------
Add PDB User Result:
(2 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQEPLLGAEGPDYDTFPEKPPPSPGDR
A
R
V
GTLQNKR
V
F
L
A
T
F
A
A
V
LGNFSF
G
Y
A
L
V
YTS
P
V
I
P
A
L
E
R
SLDPD
L
H
L
T
K
S
Q
A
S
W
F
G
S
V
F
T
L
GAAAG
G
L
S
A
M
I
L
N
D
L
LG
R
K
L
S
I
M
FSAVPSAA
G
Y
A
L
M
AG
A
H
G
L
W
M
L
L
L
G
R
T
L
T
GFAGG
L
T
A
A
C
I
P
V
Y
V
S
EIAPPGVRGALGA
T
P
Q
L
M
A
V
F
G
S
L
S
L
Y
A
L
G
L
LL
P
W
R
W
LAVAGE
A
P
V
L
I
M
I
L
L
L
S
FMPNS
P
R
F
L
L
SRGR
D
E
E
A
L
R
A
L
A
W
LRGT
D
V
D
V
H
W
E
F
E
Q
I
Q
D
N
V
R
R
Q
SSRVS
W
A
EARAPHVC
R
P
I
T
V
A
L
L
M
R
L
L
Q
Q
L
TG
I
T
P
I
L
V
Y
L
Q
S
I
FDS
T
A
V
L
LPPKD
D
A
A
I
V
G
A
V
R
L
L
S
V
L
I
A
A
L
T
M
DLAG
R
K
V
L
L
F
V
S
A
A
I
M
F
AAN
L
T
L
G
L
Y
I
H
FGPRPLSPNSTAGLESE
S
W
G
D
L
A
Q
P
L
AAPA
G
Y
L
T
L
V
P
L
L
A
T
M
L
F
I
M
G
YAV
G
W
G
P
I
T
W
L
L
M
S
E
VL
P
L
RAR
G
V
A
S
G
L
C
V
L
A
S
W
L
T
A
F
V
L
T
K
S
F
L
P
V
V
S
TFGLQ
V
P
F
F
F
F
A
A
I
C
L
V
S
L
V
FTGCCVPETKGR
S
L
E
Q
I
E
S
F
F
R
T
G
R
R
S
FLR
51
-
99%
-139
- C4 -
-
U051
-
A:
[35-486]
----------------------------------
N
K
R
V
F
L
A
T
F
A
A
V
L
G
N
F
S
F
G
Y
A
L
V
Y
T
S
P
V
I
P
A
L
E
R
S
L
D
P
D
L
H
L
T
K
S
Q
A
S
W
F
G
S
V
F
T
L
G
A
A
A
G
G
L
S
A
M
I
L
N
D
L
L
G
R
K
L
S
I
M
F
S
A
V
P
S
A
A
G
Y
A
L
M
A
G
A
H
G
L
W
M
L
L
L
G
R
T
L
T
G
F
A
G
G
L
T
A
A
C
I
P
V
Y
V
S
E
I
A
P
P
G
V
R
G
A
L
G
A
T
P
Q
L
M
A
V
F
G
S
L
S
L
Y
A
L
G
L
L
L
P
W
R
W
L
A
V
A
G
E
A
P
V
L
I
M
I
L
L
L
S
F
M
P
N
S
P
R
F
L
L
S
R
G
R
D
E
E
A
L
R
A
L
A
W
L
R
G
T
D
-
D
V
H
W
E
F
E
Q
I
Q
D
N
V
R
R
Q
S
S
R
V
S
W
A
E
A
R
A
P
H
V
C
R
P
I
T
V
A
L
L
M
R
L
L
Q
Q
L
T
G
I
T
P
I
L
V
Y
L
Q
S
I
F
D
S
T
A
V
L
P
P
-
K
D
D
A
A
I
V
G
A
V
R
L
L
S
V
L
I
A
A
L
T
M
D
L
A
G
R
K
V
L
L
F
V
S
A
A
I
M
F
A
A
N
L
T
L
G
L
Y
I
H
F
G
P
R
-------------------------
A
G
Y
L
T
L
V
P
L
L
A
T
M
L
F
I
M
G
Y
A
V
G
W
G
P
I
T
W
L
L
M
S
E
V
L
P
L
R
A
R
G
V
A
S
G
L
C
V
L
A
S
W
L
T
A
F
V
L
T
K
S
F
L
P
V
V
S
T
F
G
-
Q
V
P
F
F
F
F
A
A
I
C
L
V
S
L
V
F
T
G
C
C
V
P
E
T
---------------------
52
-
99%
-123
- C4 -
-
U052
-
A:
[29-503]
----------------------------
R
V
G
T
L
Q
N
K
R
V
F
L
A
T
F
A
A
V
L
G
N
F
S
F
G
Y
A
L
V
Y
T
S
P
V
I
P
A
L
E
R
S
L
D
P
D
L
H
L
T
K
S
Q
A
S
W
F
G
S
V
F
T
L
G
A
A
A
G
G
L
S
A
M
I
L
N
D
L
L
G
R
K
L
S
I
M
F
S
A
V
P
S
A
A
G
Y
A
L
M
A
G
A
H
G
L
W
M
L
L
L
G
R
T
L
T
G
F
A
G
G
L
T
A
A
C
I
P
V
Y
V
S
E
I
A
P
P
G
V
R
G
A
L
G
A
T
P
Q
L
M
A
V
F
G
S
L
S
L
Y
A
L
G
L
L
L
P
W
R
W
L
A
V
A
G
E
A
P
V
L
I
M
I
L
L
L
S
F
M
P
N
S
P
R
F
L
L
S
R
G
R
D
E
E
A
L
R
A
L
A
W
L
R
G
T
D
-
D
V
H
W
E
F
E
Q
I
Q
D
N
V
R
R
Q
S
S
R
V
S
W
A
E
A
R
A
P
H
V
C
R
P
I
T
V
A
L
L
M
R
L
L
Q
Q
L
T
G
I
T
P
I
L
V
Y
L
Q
S
I
F
D
S
T
A
V
L
P
P
-
K
D
D
A
A
I
V
G
A
V
R
L
L
S
V
L
I
A
A
L
T
M
D
L
A
G
R
K
V
L
L
F
V
S
A
A
I
M
F
A
A
N
L
T
L
G
L
Y
I
H
F
G
P
R
-------------------------
A
G
Y
L
T
L
V
P
L
L
A
T
M
L
F
I
M
G
Y
A
V
G
W
G
P
I
T
W
L
L
M
S
E
V
L
P
L
R
A
R
G
V
A
S
G
L
C
V
L
A
S
W
L
T
A
F
V
L
T
K
S
F
L
P
V
V
S
T
F
G
-
Q
V
P
F
F
F
F
A
A
I
C
L
V
S
L
V
F
T
G
C
C
V
P
E
T
K
G
R
S
L
E
Q
I
E
S
F
F
R
T
G
R
R
----