@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GTR8_HUMAN: (2018-03-06 )
MTPEDPEETQPLLGPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPPAPRLDDAAASWFGAVVTLGAAAGGVLGGWLVDRAGRKLSLLLCSVPFVAGFAVITAAQDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVLEWRWLAVLGCVPPSLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLWGSEQGWEDPPIGAEQSFHLALLRQPGIYKPFIIGVSLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGVIQVLFTAVAALIMDRAGRRLLLVLSGVVMVFSTSAFGAYFKLTQGGPGNSSHVAISAPVSAQPVDASVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWLMAFLVTKEFSSLMEVLRPYGAFWLASAFCIFSVLFTLFCVPETKGKTLEQITAHFEGR
Atome Classification :
(15 SA)
.........10........20........30........40........50.....----------.-..60---------.----------.----------.......70......---..80........90........100...-....----------110-....------------------.------------------..---..120....--------...130.......140.......150.......160.......170.------...--.------------..--180----------........--.190.......200.......210...-.-..-..220.......------230---..---------.------....240..---------.....250....-----...260.......270.......280...--...--.--290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420......------.430----..------.......440.......450.......460.......470.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTPEDPEETQPLLGPPGGSAPRGR
R
V
F
L
A
A
F
A
A
A
L
G
P
L
S
F
G
F
ALGYSSPAIP
S
L
Q
R----------A-APP----------A----------P----------RL
D
D
A
A
A
S
W
F
G
A
V
V
T
---
L
GAAA
G
G
V
L
G
G
W
L
V
DRAG
R
K
L
S
L
L
L
CS
V
-
P
F
V
A
----------
G
---
F
A
V
I
------------------
T
------------------
A
A
---
Q
D
V
W
M
L
L
G
G
--------
R
L
L
T
G
L
A
C
G
V
A
S
L
V
A
P
V
Y
I
S
E
I
A
Y
P
A
V
R
G
L
L
G
S
C
V
Q
L
M
V
V
V
G
I
L
L
A
Y
------
L
A
G
--
W
------------
V
L
--
E
------------
W
R
W
L
A
V
LG--CV
P
P
S
L
M
L
L
L
M
C
FMPET
P
R
F
L
L
-
T
Q
H
R
-
R
-
Q
E
-
A
M
A
A
L
R
F
L
WGSE------QGW---ED---------P------PIGAEQ
S
F
H
---------
L
A
L
LRQPGIY
K
P
-----
F
I
I
G
V
S
L
M
A
F
Q
Q
LSG
V
N
A
V
M
F
Y
A
E
T
I
F
E
E
--AKF--K--D
S
S
L
A
S
V
V
V
G
V
I
Q
V
L
F
T
A
V
A
A
L
I
M
D
RAG
R
R
L
L
L
V
L
S
G
V
V
M
V
F
STSAF
G
A
Y
F
K
L
TQGGPGNS
S
H
V
A
I
SAPVSAQPV
D
A
S
V
G
L
A
W
L
A
V
G
S
M
C
L
F
I
A
G
F
AVGWG
P
I
P
W
L
L
M
S
E
IF
P
L
H
V
K
G
V
A
T
G
I
C
V
L
T
N
W
L
M
A
F
L
V
T
K
E
F
------
S
S
------
L
M
------
E
V
L
R
P
Y
G
A
F
W
L
A
S
A
F
C
I
F
S
V
L
F
T
L
FCVPETKG
K
T
L
E
Q
I
T
A
HFEGR
1
PsiBlast_PDB
90.56
31%
-122
- C2 -
-
4ZW9
4
GTR3_HUMAN
A:
[39-490]
--------------------------------
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
T
D
K
G
N
-
A
P
P
----------
S
----------
E
----------
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
-
L
A
V
T
----------
G
G
C
F
M
G
L
C
------------------
K
------------------
V
A
---
K
S
V
E
M
L
I
L
G
--------
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
------
I
F
G
LE
F
------------
I
L
GS
E
------------
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
K
-
E
-
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
------
D
V
S
---
Q
D
---------
I
------
Q
E
M
K
D
E
S
A
R
M
S
Q
E
KQVT
V
L
E
L
F
R
V
S
S
Y
R
Q
P
-----
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
--
A
G
V
--
Q
--
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
---------------------
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
------
P
S
------
A
A
------
H
Y
L
G
A
Y
-
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
2
PsiBlast_PDB
89.35
31%
-119
- C2 -
-
4ZWB
1
GTR3_HUMAN
A:
[39-490]
--------------------------------
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
T
D
K
G
N
-
A
P
P
----------
S
----------
E
----------
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
-
L
A
V
T
----------
G
G
C
F
M
G
L
C
------------------
K
------------------
V
A
---
K
S
V
E
M
L
I
L
G
--------
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
------
I
F
G
LE
F
------------
I
L
GS
E
------------
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
K
-
E
-
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
------
D
V
S
---
Q
D
---------
I
------
Q
E
M
K
D
E
S
A
R
M
S
Q
E
KQVT
V
L
E
L
F
R
V
S
S
Y
R
Q
P
-----
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
--
A
G
V
--
Q
--
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
---------------------
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
------
P
S
------
A
A
------
H
Y
L
G
A
Y
-
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
19
HHSearch
88.80
30%
-128
- C2 -
-
5EQG
1
GTR1_HUMAN
A:
[10-455]
-----------------------
G
R
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
----------
F
-
Y
N
Q
----------
T
----------
W
V
H
R
YGESIL
P
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
-
L
A
F
V
----------
S
---
A
V
L
M
------------------
G
------------------
F
S
KLG
K
S
F
E
M
L
I
L
G
--------
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
------
V
F
G
--
L
DSIMGN------
K
D
--
L
------------
W
P
L
L
L
S
I
I
--
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
N
E
E
-
N
R
-
A
K
S
V
L
K
K
L
R
G
T
A
------
D
V
T
H
D
L
Q
E
---------
M
K
E
E
S
R
Q
M
M
R
E
K
K
V
T
I
---------
L
E
L
F
R
S
P
A
Y
R
Q
P
-----
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
--
A
G
V
--
Q
--
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
E
R
A
G
R
R
T
L
H
L
I
G
L
A
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
Q
L
--------------------
P
W
M
-
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
------
Q
Y
------
V
E
------
Q
L
C
G
P
Y
-
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
---------------
3
PsiBlast_PDB
87.65
31%
-118
- C2 -
-
4ZWC
3
GTR3_HUMAN
A:
[39-490]
--------------------------------
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
T
D
K
G
N
-
A
P
P
----------
S
----------
E
----------
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
-
L
A
V
T
----------
G
G
C
F
M
G
L
C
------------------
K
------------------
V
A
---
K
S
V
E
M
L
I
L
G
--------
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
------
I
F
G
LE
F
------------
I
L
GS
E
------------
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
K
-
E
-
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
------
D
V
S
---
Q
D
---------
I
------
Q
E
M
K
D
E
S
A
R
M
S
Q
EKQVT
V
L
E
L
F
R
V
S
S
Y
R
Q
P
-----
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
--
A
G
V
--
Q
--
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
---------------------
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
------
P
S
------
A
A
------
H
Y
L
G
A
Y
-
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
41
Fugue
86.67
30%
-141
* C2 *
-
4GC0
5
XYLE_ECOLI
A:
[5-479]
--------------------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
----------
V
-
F
V
A
----------
P
QNLS------
E
----------
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
---
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
-
L
F
F
I
----------
S
---
G
V
G
S
A
WPELGFTSINPDNTVPV
Y
------------------
L
A
---
G
Y
V
P
E
F
V
I
Y
--------
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
------
C
V
N
--
Y
------------
F
I
--
A
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
G
K
-
Q
-
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
------
L
A
T
---
Q
A
---------
V
------
Q
E
I
K
H
S
L
D
H
---------
G
R
K
T
G
G
R
L
L
M
F
G
VG
V
--
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
--
L
G
A
S
T
D
--
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
-------------------------
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
------
P
M
M
D
K
N
S
W
L
V
------
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--
22
HHSearch
85.60
31%
-124
- C2 -
-
4GC0
5
XYLE_ECOLI
A:
[8-472]
-----------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
----------
V
-
F
V
A
----------
P
QNLS------
E
----------
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
---
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
-
L
F
F
I
----------
S
---
G
V
G
S
------------------
A
WPELGFTSINPDNTVPVY
L
A
---
G
Y
V
P
E
F
V
I
Y
--------
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
------
C
V
N
--
Y
F
I
A
R
S
GD
A
S
W
L
N
T
D
--
G
------------
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
G
K
-
Q
-
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
------
L
A
T
---
Q
A
---------
V
------
Q
-
E
I
K
H
S
L
D
----------
H
G
R
K
T
G
G
R
L
L
M
F
GVG
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
--
L
G
A
--
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
-
T
Q
----------------------
A
-
P
-
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
------
P
M
------
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
---------
21
HHSearch
85.39
31%
-126
- C2 -
-
4GBY
5
XYLE_ECOLI
A:
[8-472]
-----------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
----------
V
-
F
V
A
----------
P
QNLS------
E
----------
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
---
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
-
L
F
F
I
----------
S
---
G
V
G
S
------------------
A
WPELGFTSINPDNTVPVY
L
A
---
G
Y
V
P
E
F
V
I
Y
--------
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
------
C
V
N
--
Y
F
I
A
R
SGD
A
S
W
L
N
T
D
--
G
------------
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
G
K
-
Q
-
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
------
L
A
T
---
Q
A
---------
V
------
Q
-
E
I
K
H
S
L
D
----------
H
G
R
K
T
G
G
R
L
L
M
F
GVG
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
--
L
G
A
--
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
-
T
Q
----------------------
A
-
P
-
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
------
P
M
------
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
---------
10
PsiBlast_PDB
85.22
28%
-114
- C2 -
-
5EQG
1
GTR1_HUMAN
A:
[11-455]
------------------------
R
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
----------
F
-
Y
N
Q
----------
T
W
V
H
R
YGESIL
P
----------
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
------
G
---
F
S
K
L
--------------------------------------
G
---
K
S
F
E
M
L
I
L
G
--------
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
LDS
I
M
G
--
N
------------
K
D
--
L
------------
W
P
L
L
L
S
I
I
--
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
N
E
-
E
-
N
R
-
A
K
S
V
L
K
K
L
R
G
T
A
------
D
V
T
---
H
D
---------
L
------
Q
E
M
K
E
E
S
R
Q
M
M
REKKVT
I
L
E
L
F
R
S
P
A
Y
R
Q
P
-----
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
--
A
G
V
--
Q
--
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
E
R
A
G
R
R
T
L
H
L
I
---------------------
G
L
A
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
------
Q
Y
------
V
E
------
Q
L
C
G
P
Y
-
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
---------------
11
PsiBlast_PDB
84.85
28%
-116
- C2 -
-
5EQH
1
GTR1_HUMAN
A:
[11-455]
------------------------
R
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
----------
F
-
Y
N
Q
----------
T
W
V
H
R
YGESIL
P
----------
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
------
G
---
F
S
K
L
--------------------------------------
G
---
K
S
F
E
M
L
I
L
G
--------
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
LDS
I
M
G
--
N
------------
K
D
--
L
------------
W
P
L
L
L
S
I
I
--
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
N
E
-
E
-
N
R
-
A
K
S
V
L
K
K
L
R
G
T
A
------
D
V
T
---
H
D
---------
L
------
Q
E
M
K
E
E
S
R
Q
M
M
REKKVT
I
L
E
L
F
R
S
P
A
Y
R
Q
P
-----
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
--
A
G
V
--
Q
--
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
E
R
A
G
R
R
T
L
H
L
I
---------------------
G
L
A
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
------
Q
Y
------
V
E
------
Q
L
C
G
P
Y
-
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
---------------
12
PsiBlast_PDB
84.66
28%
-116
- C2 -
-
5EQI
1
GTR1_HUMAN
A:
[11-455]
------------------------
R
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
----------
F
-
Y
N
Q
----------
T
W
V
H
R
YGESIL
P
----------
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
------
G
---
F
S
K
L
--------------------------------------
G
---
K
S
F
E
M
L
I
L
G
--------
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
GLDS
I
M
G
--
N
------------
K
D
--
L
------------
W
P
L
L
L
S
I
I
--
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
N
E
-
E
-
N
R
-
A
K
S
V
L
K
K
L
R
G
T
A
------
D
V
T
---
H
D
---------
L
------
Q
E
M
K
E
E
S
R
Q
M
M
R
E
K
K
V
T
I
L
E
L
F
R
S
P
A
Y
R
Q
P
-----
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
--
A
G
V
--
Q
--
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
E
R
A
G
R
R
T
L
H
L
I
---------------------
G
L
A
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
------
Q
Y
------
V
E
------
Q
L
C
G
P
Y
-
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
---------------
9
PsiBlast_PDB
84.61
29%
-134
- C2 -
-
4GC0
5
XYLE_ECOLI
A:
[10-479]
-------------------------
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
----------
V
F
V
A
P
----------
Q
----------
N
----------
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
-
L
F
F
I
S
G
V
G
S
A
WPEL
G
---
F
T
S
I
------------------
N
------------------
P
D
---
N
T
V
P
V
Y
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
------
C
V
N
--
Y
------------
F
I
--
A
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
G
K
-
Q
-
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
---
K
H
---------
S
------
L
D
H
G
R
K
T
G
G
---------
R
L
L
M
F
G
V
G
V
--------
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
--
D
--
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
-
Y
T
Q
-
A
P
G
-----------------------
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
------
L
V
------
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--
20
HHSearch
84.43
30%
-121
- C2 -
-
4ZW9
4
GTR3_HUMAN
A:
[28-452]
---------------------
V
T
P
A
L
I
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
----------
F
-
I
T
K
T
L
T
D
K
GNAPP
S
----------
E
----------
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
-
L
A
V
T
----------
G
---
G
C
F
M
------------------
G
L
CK---------------
V
A
---
K
S
V
E
M
L
I
L
G
--------
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
------
I
F
G
--
L
EFILGS------
E
E
--
L
------------
W
P
L
L
L
G
F
T
--
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
K
-
E
E
E
N
-
A
K
Q
I
L
Q
R
L
W
G
T
Q
------
D
V
S
---
Q
D
I
Q
E
M
K
D
E
S
A
R
------
M
S
Q
E
K
Q
V
T
V
---------
L
E
L
F
R
V
S
S
Y
R
Q
P
-----
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
--
A
G
V
--
Q
--
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
-------------------
N
G
M
S
-
F
V
C
I
G
A
I
L
V
F
V
A
F
F
-
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
------
P
S
------
A
A
------
H
Y
L
G
A
Y
---------------------------------------
7
PsiBlast_PDB
83.69
29%
-134
- C2 -
-
4GBY
5
XYLE_ECOLI
A:
[10-479]
-------------------------
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
----------
V
F
V
A
P
----------
Q
----------
N
----------
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
-
L
F
F
I
S
G
V
G
S
A
WPEL
G
---
F
T
S
I
------------------
N
------------------
P
D
---
N
T
V
P
V
Y
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
------
C
V
N
--
Y
------------
F
I
--
A
R
SGD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
G
K
-
Q
-
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
---
K
H
---------
S
------
L
D
H
G
R
K
T
G
G
---------
R
L
L
M
F
G
V
G
V
--------
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
LG
A
S
T
--
D
--
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
-
Y
T
Q
-
A
P
G
-----------------------
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
------
L
V
------
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--
8
PsiBlast_PDB
83.41
29%
-131
- C2 -
-
4GBZ
5
XYLE_ECOLI
A:
[10-479]
-------------------------
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
----------
V
F
V
A
P
----------
Q
----------
N
----------
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
-
L
F
F
I
S
G
V
G
S
A
W
PEL
G
---
F
T
S
I
------------------
N
------------------
P
D
---
N
T
V
P
V
Y
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
------
C
V
N
--
Y
------------
F
I
--
A
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
G
K
-
Q
-
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
---
K
H
---------
S
------
L
D
H
G
R
K
T
G
G
---------
R
L
L
M
F
G
V
G
V
--------
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
--
D
--
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
-
Y
T
Q
-
A
P
G
-----------------------
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
------
L
V
------
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--
13
PsiBlast_PDB
83.24
28%
-112
- C2 -
-
4PYP
1
GTR1_HUMAN
A:
[11-455]
------------------------
R
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
----------
F
-
Y
T
Q
----------
T
W
V
H
R
YG
E
S
I
L
P
----------
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
------
G
---
F
S
K
L
--------------------------------------
G
---
K
S
F
E
M
L
I
L
G
--------
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
LDS
I
M
G
--
N
------------
K
D
--
L
------------
W
P
L
L
L
S
I
I
--
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
N
E
-
E
-
N
R
-
A
K
S
V
L
K
K
L
R
G
T
A
------
D
V
T
---
H
D
---------
L
------
Q
E
M
K
E
E
S
R
Q
MMREKKVT
I
L
E
L
F
R
S
P
A
Y
R
Q
P
-----
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
--
A
G
V
--
Q
--
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
---------------------
G
L
A
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
------
Q
Y
------
V
E
------
Q
L
C
G
P
Y
-
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
---------------
Add PDB User Result:
(2 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTPEDPEETQPLLGPPGGSAPRGR
R
V
F
L
A
A
F
A
A
A
L
G
P
L
S
F
G
F
ALGYSSPAIP
S
L
Q
RAAPPAPRL
D
D
A
A
A
S
W
F
G
A
V
V
T
L
GAAA
G
G
V
L
G
G
W
L
V
DRAG
R
K
L
S
L
L
L
CS
V
P
F
V
A
G
F
A
V
I
T
A
A
Q
D
V
W
M
L
L
G
G
R
L
L
T
G
L
A
C
G
V
A
S
L
V
A
P
V
Y
I
S
E
I
A
Y
P
A
V
R
G
L
L
G
S
C
V
Q
L
M
V
V
V
G
I
L
L
A
Y
L
A
G
W
V
L
E
W
R
W
L
A
V
LGCV
P
P
S
L
M
L
L
L
M
C
FMPET
P
R
F
L
L
T
Q
H
R
R
Q
E
A
M
A
A
L
R
F
L
WGSEQGWEDPPIGAEQ
S
F
H
L
A
L
LRQPGIY
K
P
F
I
I
G
V
S
L
M
A
F
Q
Q
LSG
V
N
A
V
M
F
Y
A
E
T
I
F
E
E
AKFKD
S
S
L
A
S
V
V
V
G
V
I
Q
V
L
F
T
A
V
A
A
L
I
M
D
RAG
R
R
L
L
L
V
L
S
G
V
V
M
V
F
STSAF
G
A
Y
F
K
L
TQGGPGNS
S
H
V
A
I
SAPVSAQPV
D
A
S
V
G
L
A
W
L
A
V
G
S
M
C
L
F
I
A
G
F
AVGWG
P
I
P
W
L
L
M
S
E
IF
P
L
H
V
K
G
V
A
T
G
I
C
V
L
T
N
W
L
M
A
F
L
V
T
K
E
F
S
S
L
M
E
V
L
R
P
Y
G
A
F
W
L
A
S
A
F
C
I
F
S
V
L
F
T
L
FCVPETKG
K
T
L
E
Q
I
T
A
HFEGR
51
-
100%
-170
- C2 -
-
U051
-
A:
[23-462]
----------------------
G
R
R
V
F
L
A
A
F
A
A
A
L
G
P
L
S
F
G
F
A
L
G
Y
S
S
P
A
I
P
S
L
Q
R
A
A
P
P
A
P
R
L
D
D
A
A
A
S
W
F
G
A
V
V
T
L
G
A
A
A
G
G
V
L
G
G
W
L
V
D
R
A
G
R
K
L
S
L
L
L
C
S
V
P
F
V
A
G
F
A
V
I
T
A
A
Q
D
V
W
M
L
L
G
G
R
L
L
T
G
L
A
C
G
V
A
S
L
V
A
P
V
Y
I
S
E
I
A
Y
P
A
V
R
G
L
L
G
S
C
V
Q
L
M
V
V
V
G
I
L
L
A
Y
L
A
G
W
V
L
E
W
R
W
L
A
V
L
G
C
V
P
P
S
L
M
L
L
L
M
C
F
M
P
E
T
P
R
F
L
L
T
Q
H
R
R
Q
E
A
M
A
A
L
R
F
L
W
G
S
E
Q
G
W
E
D
P
P
I
G
A
E
Q
S
F
H
L
A
L
L
R
Q
P
G
I
Y
K
P
F
I
I
G
V
S
L
M
A
F
Q
Q
L
S
G
V
N
A
V
M
F
Y
A
E
T
I
F
E
E
A
K
F
K
D
S
S
L
A
S
V
V
V
G
V
I
Q
V
L
F
T
A
V
A
A
L
I
M
D
R
A
G
R
R
L
L
L
V
L
S
G
V
V
M
V
F
S
T
S
A
F
G
A
Y
F
K
L
T
Q
G
---------------------
S
V
G
L
A
W
L
A
V
G
S
M
C
L
F
I
A
G
F
A
V
G
W
G
P
I
P
W
L
L
M
S
E
I
F
P
L
H
V
K
G
V
A
T
G
I
C
V
L
T
N
W
L
M
A
F
L
V
T
K
E
F
S
S
L
M
E
V
L
R
-
Y
G
A
F
W
L
A
S
A
F
C
I
F
S
V
L
F
T
L
F
C
V
P
E
T
---------------
52
-
100%
-153
- C2 -
-
U052
-
A:
[17-477]
----------------
G
G
S
A
P
R
G
R
R
V
F
L
A
A
F
A
A
A
L
G
P
L
S
F
G
F
A
L
G
Y
S
S
P
A
I
P
S
L
Q
R
A
A
P
P
A
P
R
L
D
D
A
A
A
S
W
F
G
A
V
V
T
L
G
A
A
A
G
G
V
L
G
G
W
L
V
D
R
A
G
R
K
L
S
L
L
L
C
S
V
P
F
V
A
G
F
A
V
I
T
A
A
Q
D
V
W
M
L
L
G
G
R
L
L
T
G
L
A
C
G
V
A
S
L
V
A
P
V
Y
I
S
E
I
A
Y
P
A
V
R
G
L
L
G
S
C
V
Q
L
M
V
V
V
G
I
L
L
A
Y
L
A
G
W
V
L
E
W
R
W
L
A
V
L
G
C
V
P
P
S
L
M
L
L
L
M
C
F
M
P
E
T
P
R
F
L
L
T
Q
H
R
R
Q
E
A
M
A
A
L
R
F
L
W
G
S
E
Q
G
W
E
D
P
P
I
G
A
E
Q
S
F
H
L
A
L
L
R
Q
P
G
I
Y
K
P
F
I
I
G
V
S
L
M
A
F
Q
Q
L
S
G
V
N
A
V
M
F
Y
A
E
T
I
F
E
E
A
K
F
K
D
S
S
L
A
S
V
V
V
G
V
I
Q
V
L
F
T
A
V
A
A
L
I
M
D
R
A
G
R
R
L
L
L
V
L
S
G
V
V
M
V
F
S
T
S
A
F
G
A
Y
F
K
L
T
Q
G
---------------------
S
V
G
L
A
W
L
A
V
G
S
M
C
L
F
I
A
G
F
A
V
G
W
G
P
I
P
W
L
L
M
S
E
I
F
P
L
H
V
K
G
V
A
T
G
I
C
V
L
T
N
W
L
M
A
F
L
V
T
K
E
F
S
S
L
M
E
V
L
R
-
Y
G
A
F
W
L
A
S
A
F
C
I
F
S
V
L
F
T
L
F
C
V
P
E
T
K
G
K
T
L
E
Q
I
T
A
H
F
E
G
R