@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GTR9_HUMAN: (2018-03-06 )
MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYCFLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP
Atome Classification :
(12 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......---------------160-------------.........170.......180.......190.......200.......210.......220....------...230----.........240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.-......390.......400.......410.......420.......430.......440.......450.......460.......470...------...-------.480.......490.......500.......510.......520.......530.......540
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MARKQNRNSKELG
L
V
PLTDDTSHAGPPGPG
R
A
L
L
E
C
D
H
L
RSGVPGGRRRKDW
S
C
S
L
L
V
A
S
L
A
G
A
F
GS
S
F
L
Y
G
Y
N
L
S
VVNAP
T
P
Y
I
K
A
F
Y
N
E
S
W
E
RRHGRPIDPD
T
L
T
L
L
W
S
V
T
V
S
I
F
A
I
G
G
L
V
G
T
L
I
V
K
M
I
G
K
V
LGRK
H
T
L
LANNG
F
A
I
S
A
A
L
L
M
A
C
SL---------------Q---------------AGA
F
E
M
L
I
V
G
R
F
I
MGIDG
G
V
A
L
S
V
L
P
M
Y
L
S
EI
S
P
K
E
I
R
GSLG
Q
V
T
A
I
F
I
C
I
G
V
F
T
G
Q
L
LG
L
P
E
L
LG------KEST------W
P
Y
L
F
G
V
I
V
V
P
A
V
V
Q
L
LSLPFLPDSP
R
Y
L
L
L
EKHNE
A
R
A
V
K
A
F
Q
T
F
LGKA
D
V
S
Q
E
V
E
E
V
L
A
E
S
R
V
Q
R
S
I
R
L
V
S
V
L
E
L
L
RAPY
V
R
W
Q
V
V
T
V
I
V
T
M
A
C
Y
Q
L
CGL
N
A
I
W
F
YTNSIFGKAGIPPAK
I
P
Y
V
T
LSTG
G
I
E
T
L
A
A
V
F
S
G
L
V
I
E
HLGRR
P
L
-
L
I
G
G
F
G
L
M
G
L
F
FG
T
L
T
I
T
L
T
LQDHAP
W
V
P
Y
L
S
I
V
G
I
L
A
I
I
A
S
FCSGPGG
I
P
F
I
L
T
G
E
F
F
Q
QSQR
P
A
A
F
I
I
A
G
T
V
N
W
L
S
N
F
A
V
G
L
L
F
P
F
I
Q
K
S
------
L
D
T
-------
Y
C
F
L
V
F
A
T
I
C
I
TG
A
I
Y
L
Y
F
VLPETKN
R
T
Y
A
E
I
S
Q
A
F
S
KRNKAYP
P
E
E
K
I
D
S
AVTDGKINGRP
4
PsiBlast_PDB
94.19
39%
-144
- C3 -
-
5EQH
1
GTR1_HUMAN
A:
[12-455]
--------------------------------------------------------
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
F
Y
N
Q
T
W
V
H
R
Y
G
E
S
I
L
P
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
F
S
K
---------------
L
---------------
G
K
S
F
E
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
L
D
S
I
M
G
------
N
K
D
L
------
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
N
E
E
N
R
A
K
S
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
E
E
S
R
Q
M
M
R
E
K
K
V
T
I
L
E
L
F
R
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
--
Q
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
E
R
A
G
R
R
T
L
H
L
I
G
L
A
G
M
A
G
C
A
I
-
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
V
E
Q
L
------
C
G
P
-------
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
--------------------------------------
5
PsiBlast_PDB
93.23
39%
-145
- C3 -
-
5EQI
1
GTR1_HUMAN
A:
[12-455]
--------------------------------------------------------
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
F
Y
N
Q
T
W
V
H
R
Y
G
E
S
I
L
P
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
F
S
K
---------------
L
---------------
G
K
S
F
E
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
L
D
S
I
M
G
------
N
K
D
L
------
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
N
E
E
N
R
A
K
S
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
E
E
S
R
Q
M
M
R
E
K
K
V
T
I
L
E
L
F
R
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
--
Q
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
E
R
A
G
R
R
T
L
H
L
I
G
L
A
G
M
A
G
C
A
I
-
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
V
E
Q
L
------
C
G
P
-------
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
--------------------------------------
3
PsiBlast_PDB
93.12
39%
-142
- C3 -
-
5EQG
1
GTR1_HUMAN
A:
[12-455]
--------------------------------------------------------
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
F
Y
N
Q
T
W
V
H
R
Y
G
E
S
I
L
P
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
F
S
K
---------------
L
---------------
G
K
S
F
E
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
L
D
S
I
M
G
------
N
K
D
L
------
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
N
E
E
N
R
A
K
S
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
E
E
S
R
Q
M
M
R
E
K
K
V
T
I
L
E
L
F
R
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
--
Q
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
E
R
A
G
R
R
T
L
H
L
I
G
L
A
G
M
A
G
C
A
I
-
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
V
E
Q
L
------
C
G
P
-------
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
--------------------------------------
6
PsiBlast_PDB
92.81
38%
-141
- C3 -
-
4PYP
1
GTR1_HUMAN
A:
[12-455]
--------------------------------------------------------
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
F
Y
T
Q
T
W
V
H
R
Y
G
E
S
I
L
P
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
F
S
K
---------------
L
---------------
G
K
S
F
E
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
L
D
S
I
M
G
------
N
K
D
L
------
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
N
E
E
N
R
A
K
S
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
E
E
S
R
Q
M
M
R
E
K
K
V
T
I
L
E
L
F
R
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
--
Q
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
L
A
G
M
A
G
C
A
I
-
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
V
E
Q
L
------
C
G
P
-------
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
--------------------------------------
18
HHSearch
92.64
39%
-151
- C3 -
-
5EQG
1
GTR1_HUMAN
A:
[20-455]
----------------------------------------------------------------
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
F
Y
N
Q
T
W
V
H
R
Y
G
E
S
I
L
P
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
F
S
K
---------------
L
---------------
G
K
S
F
E
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
L
D
S
I
M
G
------
N
K
D
L
------
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
N
E
E
N
R
A
K
S
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
E
E
S
R
Q
M
M
R
E
K
K
V
T
I
L
E
L
F
R
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
--
Q
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
E
R
A
G
R
R
T
L
-
H
L
I
G
L
A
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
V
E
Q
L
------
C
G
P
-------
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
--------------------------------------
20
HHSearch
85.17
37%
-133
- C3 -
-
4ZW9
4
GTR3_HUMAN
A:
[39-488]
---------------------------------------------------------------
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
C
K
---------------
V
---------------
A
K
S
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
G
------
S
E
E
L
------
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
--
D
A
G
V
Q
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
-
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
A
A
H
Y
------
L
G
A
-------
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
-------------------------
7
PsiBlast_PDB
84.64
37%
-133
- C3 -
-
4ZW9
4
GTR3_HUMAN
A:
[43-490]
-------------------------------------------------------------------
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
C
K
---------------
V
---------------
A
K
S
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
G
------
S
E
E
L
------
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
Q
E
P
I
--
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
-
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
A
A
H
Y
------
L
G
A
-------
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
-----------------------
8
PsiBlast_PDB
84.23
37%
-132
- C3 -
-
4ZWB
1
GTR3_HUMAN
A:
[43-490]
-------------------------------------------------------------------
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
C
K
---------------
V
---------------
A
K
S
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
G
------
S
E
E
L
------
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
Q
E
P
I
--
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
-
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
A
A
H
Y
------
L
G
A
-------
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
-----------------------
9
PsiBlast_PDB
83.81
37%
-138
- C3 -
-
4ZWC
3
GTR3_HUMAN
A:
[43-490]
-------------------------------------------------------------------
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
C
K
---------------
V
---------------
A
K
S
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
G
------
S
E
E
L
------
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
Q
E
P
I
--
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
-
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
A
A
H
Y
------
L
G
A
-------
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
-----------------------
42
Fugue
67.73
21%
-87
- C3 -
-
4GC0
5
XYLE_ECOLI
A:
[5-479]
---------------------------------------------------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
------
A
P
Q
N
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
W
P
E
---------------
L
GFTSINPDNTVPVYL
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
------
G
D
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
S
-
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
------
R
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
-
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
----
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
------
S
W
L
V
A
H
FHNG
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
-------------------------
23
HHSearch
63.76
22%
-88
- C3 -
-
4GC0
5
XYLE_ECOLI
A:
[19-477]
-----------------------------------------------------------------
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
------
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
W
P
E
LGFTSINPDNTVPVY
L
---------------
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
GD
A
S
W
L
N
T
D
G
------
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
S
-
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
--
H
G
R
K
T
G
G
R
L
L
M
F
G
----
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
-
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
-
Q
A
P
G
I
---
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
G------
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
---------------------------
22
HHSearch
63.47
22%
-88
- C3 -
-
4GBY
5
XYLE_ECOLI
A:
[19-477]
-----------------------------------------------------------------
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
------
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
W
P
E
LGFTSINPDNTVPVY
L
---------------
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
GD
A
S
W
L
N
T
D
G
------
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
S
-
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
--
H
G
R
K
T
G
G
R
L
L
M
F
G
----
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
-
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
-
Q
A
P
G
I
---
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
G------
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
---------------------------