@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_21_0190: (2018-03-09 )
MRLCAPLGTHTAAFRAGGTPAQEHASTGMQRGMEKTMSRDVDVESAFTALSPSAGEKEMVHGANAASGLYCFKDTLRIELPVISSEHCATFSSLADGTGGGSPETAIYRPSETAFSLEIEECTPLSIEEDNARQSAVALLQAGILPKSAGGSSRRGTSRRLPSFIPTFSSLEPIEAMRKKSPVSLFTSIRRKNICSLSMEADLTRGGEPDGVIPCSGEFNRSSGSFELHPDLTTVIARGASSAAPSPERQQRCGSTFTSPAPSQTASSMSLADESEESGDSSDQGIEMDLVLRDASKIRGLRLTWLLYMLIVMVIVLFVLVLVQITYETSRMLTRSATEAVQAQAASLLNSVDMQQYALEKLFEVMREAKITGFSPDSITHIIVRDIICSSLYRAPIAFAMYDKAGELQWKTSCKWNDTVDMLAELPKTVLPGIAFMRIVDYGKLALAYRTFYASSGGVETYVVMTEKETLGRTLMNNDMADYSTATLQSVMTAFFLPRWNSTQLTMLFHTLTKEARSYTNTPTSPSAAALTAAFESLCHTDSPYVWHIVLMPVNASGIVKQSIRAADWPETKTRTIPTPRFEYKRTWGQLSKANLCGVKCMSAEGEKCTLDNPTNVWFLVDYTMAHLESIHTTVAIVGALSVMAVVIFSVIMFLVYLSITVPVNYLRYQLMRAVGSNEMATPWQRKIVRWTYRLWLGDLTSIARSIYILSLCFRLNKKYVPDHVLRNHAKQLYMRRRKFNFLEEADLKEDTMLEHDTDSDNEAESPLVGVNTVLPPSDKRFLWHFSVTHDKDEADHAASENGVGARISDGATFAEVSPVYAPRPQLPTTSYEVVVPCGRAAPAPRGVGLPRDVPLNVKAYGELEDTVAMQEASTMAAATAMTTQSSNDIMSIRREYETTVLCIRIPSVELAYLINYSGAAHQHRRLMRVLLHRIRRHKGALFHCSGDCLGAVWNAFEGCPNHAECAAVCAQEIANAFAPYRSDGLYVGMVLHQGTLVCGTVEYSKTAFVTAFGDGPREALAVAELAAAVKTLNVLVTEPVKQALSGLYDCNIVDVIQLPNSAHPLLLFELSGSRTPERSLNDTHLQAPTQAEFSIDYARAFAQFRNHEFSKALQSIQKLRTHISSRNVHLLRRLERLCLFYSAQPAALPRPYHRAFPVWVNYEAIAQAGLRNDPHLTTSQTESLTAHNMNRGLVYQGVPVLRNDMDCIRDFKQELQANMRRLVSPQRTTRQSGSPTLDNAATPTQDSLHASLPMRSTPLPMPMSAGMLLEVSGDLSESLSAAMPAKPRYVDPQENAAEMSLPPLRPAPVVTVAPPCFIAGPPLVAASAATPIACEEAKGRNGPEWTSPEVSSPHGMPFPSRHPAVTHSATNLPPVAVAGTPDLVTASAALLQSAATHTDSINSSAQADGASCSIIQSAGLSFQGTGGMRGFCVSNETLPATIKAKNGTTYLRSTRILGKGSFGCVYLGMDAHSGRLVAIKFLPLPSDESGMEVIEAEVLILQRVNDTHVVQLLSYAFEGDTIVIFMECMLAGSLQNMIAAFRTIPSSTARVFMRDVLRGLSKLHSMGVIHRDMKPQNVLLSFAGNCKISDFGASAWLQELARKESKGEVCGTPVYLAPEAARGSPEKESDIWSCGIMFLHMITGRLPYSPEQLALGAAALVYQIGSGIAQPNIPDDLDVLDAEFVRACLDKDPSKRTSAAGLLQLALFTV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480--......1490......1500......1510......1520......1530......1540.----.....1550......1560......1570......1580--....-....1590......1600......1610......1620.-...-...1630......1640......1650......1660......-1670.......1680......1690.....-----.1700......1710----------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRLCAPLGTH
T
A
AFRAGGT
P
A
Q
E
H
A
S
T
G
M
Q
R
G
M
E
K
T
MSRDV
D
V
E
S
A
F
TALSPSAGE
K
E
M
VHGANAAS
G
L
Y
C
FK
D
T
L
R
I
ELPVISS
E
H
C
A
T
F
S
S
LADGTGGGSPE
T
A
I
YRPSE
T
A
F
S
L
E
IEECTPLSIEEDN
A
R
Q
S
A
V
A
L
L
Q
AGILPKSAGGSSRRGTSRRL
P
S
F
IPTFSSL
E
P
I
E
A
M
R
KKS
P
V
S
L
F
T
S
I
R
R
KNICSLSMEADLTRGGEPD
G
V
I
PCSGEFNRSSG
S
F
E
LHP
D
L
T
T
V
I
ARGASSAAPS
P
E
R
Q
Q
RCGSTFTSPAPSQTASSMSLADESEESGDSSDQ
G
I
E
M
D
L
V
LR
D
A
S
KIRG
L
R
L
T
W
L
L
Y
M
L
I
V
M
V
I
V
L
F
V
L
V
L
V
Q
I
T
Y
E
T
S
R
M
L
T
R
S
A
T
E
A
V
Q
A
Q
A
A
S
L
L
N
S
V
D
M
Q
Q
Y
A
L
E
K
L
F
E
V
M
R
EAKITGFSP
D
S
I
T
H
I
I
V
R
D
I
I
C
S
S
L
Y
RAP
I
A
F
A
M
YDKAGE
L
Q
W
K
TSCKWN
D
T
V
D
M
L
A
E
L
P
K
T
V
L
P
G
I
A
F
M
R
I
VDY
G
K
L
A
L
A
Y
R
T
FYASSGG
V
E
T
Y
V
V
M
T
E
K
E
T
L
G
R
T
L
M
NNDMAD
Y
S
T
A
T
L
Q
S
V
M
T
A
F
FLPRWNS
T
Q
L
T
M
L
F
H
T
L
T
K
E
A
R
SYTNTPTSP
S
A
A
A
L
T
A
A
F
E
S
L
CHTDSP
Y
V
W
H
I
V
L
M
PVNA
S
G
I
V
K
Q
S
I
RAADWPETKTRTIPTP
R
F
E
Y
K
R
T
WGQLSKANLCG
V
K
C
MSAEG
E
K
C
TLDNPT
N
V
W
F
L
V
D
Y
T
M
A
H
L
E
S
I
H
T
T
V
A
I
V
G
A
L
S
V
M
A
V
V
I
F
S
V
I
M
F
L
V
Y
L
S
I
T
V
P
V
N
Y
L
R
Y
Q
L
M
R
A
VGSNEMA
T
P
W
Q
R
K
I
V
R
W
T
Y
R
L
W
L
G
D
L
T
S
I
A
R
S
I
Y
I
L
S
L
C
F
R
LNKKYV
P
D
H
V
L
R
N
H
A
K
Q
L
Y
M
R
R
R
KFNF
L
E
EADLKE
D
T
MLEHDTDSDNEAES
P
L
V
G
V
NTVLPPSDK
R
F
L
W
H
F
S
VTHDKDEADHAASENGVGARISDG
A
T
F
AEVSPVYAPRPQLPTT
S
Y
E
V
V
V
PCGRAAPAPRGVGLPRDVPL
N
V
K
A
YGE
L
E
D
T
V
A
M
Q
E
A
S
T
M
A
A
A
T
A
MTTQSS
N
D
I
M
S
I
R
R
EYE
T
T
V
L
C
I
RIPS
V
E
L
A
Y
L
INYSG
A
A
H
Q
H
R
R
L
M
R
V
L
L
H
R
I
R
R
HK
G
A
L
F
HCS
G
D
C
L
G
A
V
W
N
A
FEGCP
N
H
A
E
C
A
A
V
C
A
Q
E
I
A
N
A
FAPYRSD
G
L
Y
V
G
M
V
L
HQ
G
T
L
V
C
G
T
V
EYS
K
T
A
F
V
T
AFGDG
P
R
E
A
L
A
V
A
E
L
A
A
A
V
K
T
L
N
V
L
V
T
E
P
V
K
Q
A
L
S
G
LYDC
N
I
V
D
V
IQLPNSAH
P
L
L
L
F
ELSGSRTPERSLNDTHLQAPTQA
E
F
S
I
D
Y
A
R
A
F
A
Q
F
RN
H
E
F
S
K
A
L
Q
S
I
Q
K
L
R
T
H
ISSR
N
V
H
L
L
R
R
L
E
R
L
C
L
F
YSAQPAALPRPYHRA
F
P
V
W
V
N
Y
E
A
I
A
Q
AGLRNDPHLTTSQTES
L
T
AHNMNRG
L
V
YQGV
P
V
LRN
D
M
D
C
I
R
D
F
K
Q
E
L
Q
A
N
M
R
R
LVSPQRTTRQSGSPTLDNAATPTQDSLHASLPMRSTPLPMPMSA
G
M
L
L
E
VSG
D
L
S
E
S
L
S
AAMPAKPRYVDPQENAAEMSLPPLRPA
P
V
V
T
VA
P
P
CFIAGPP
L
V
AASAATP
I
A
C
E
EAKGRNGPEWTSPEVSSPHGMPFPSRHPAVTHSATNLP
P
V
AVAGTP
D
L
V
T
A
S
A
A
L
L
Q
S
AATHTDSINSSAQADGA
S
C
S
I
I
Q
SAG
L
S
F
QGTGG
M
R
G
F
C
VSNETL
P
A
T
I
KAKNG
T
T
Y
L
R
S
T
R
I
LGKGSF
G
C
V
Y
L
G
MDAHS
G
R
L
V
A
I
K
F
L
--PLPSDESG
M
E
V
I
E
A
E
V
L
I
L
QRVN
D
T
H
V
V
Q
L
L
S
Y
AFEG
D
T
I
V
I
F
M
E
C
M
L
A
G
S
L
Q
N
M
I
A
A
F
R
T----IP
S
S
T
A
R
V
F
M
R
D
V
L
R
G
L
S
K
L
H
S
M
G
V
I
HRDMKPQ
N
V
L
L
----SFAG-N
C
K
ISDF
G
A
S
A
W
L
Q
E
L
A
RKESKGEVCGT
P
V
Y
LAPEAA-R-GSP-EKES
D
I
W
S
C
G
I
M
F
L
H
M
I
TGRLPY
S
P
E
Q
L
A
L
G
A
A
A
L
V
Y
Q
IGSGI-A-QPNIPD
D
L
D
V
L
D
A
E
F
V
R
A
C
LDKDPSKR
T
-----
S
A
A
G
L
L
Q
L
A
L
FTV------------------------------------------------------------------------
14
PsiBlast_PDB
74.41
34%
-100
- C1 -
-
3FXZ
1
?
A:
[22-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
-
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
--
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
-
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
----
G
M
D
G
-
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
-
L
-
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
------------------------------------------------------------------------
13
PsiBlast_PDB
73.78
34%
-95
- C1 -
-
4EQC
1
PAK1_HUMAN
A:
[26-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
-
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
--
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
-
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
----
G
M
D
G
-
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
-
L
-
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
------------------------------------------------------------------------
17
PsiBlast_PDB
73.46
34%
-97
- C1 -
-
5DFP
2
PAK1_HUMAN
A:
[22-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
-
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
--
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
-
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
----
G
M
D
G
-
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
-
L
-
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
------------------------------------------------------------------------
9
PsiBlast_PDB
72.97
34%
-99
- C1 -
-
5DEW
1
PAK1_HUMAN
A:
[22-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
-
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
-
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
----
G
M
D
G
-
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
-
L
-
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
------------------------------------------------------------------------
8
PsiBlast_PDB
72.96
34%
-102
- C1 -
-
5DEY
1
PAK1_HUMAN
A:
[22-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
-
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
-
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
----
G
M
D
G
-
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
-
L
-
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
------------------------------------------------------------------------
16
PsiBlast_PDB
72.95
34%
-100
- C1 -
-
4DAW
-
PAK1_HUMAN
A:
[22-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
-
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
--
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
-
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
----
G
M
D
G
-
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
-
L
-
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
------------------------------------------------------------------------
15
PsiBlast_PDB
72.84
34%
-96
- C1 -
-
3FY0
1
PAK1_HUMAN
A:
[22-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
-
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
--
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
-
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
----
G
M
D
G
-
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
-
L
-
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
------------------------------------------------------------------------
1
PsiBlast_PDB
72.60
35%
-94
- C1 -
-
1YHV
-
?
A:
[270-523]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
-
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
--
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
-
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
----
G
M
D
G
-
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
-
L
-
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
------------------------------------------------------------------------
11
PsiBlast_PDB
72.04
34%
-106
- C1 -
-
4ZJJ
1
PAK1_HUMAN
A:
[24-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
-
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
-
Q
----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
-
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
----
G
M
D
G
-
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
-
L
-
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
------------------------------------------------------------------------
7
PsiBlast_PDB
71.98
34%
-94
- C1 -
-
1YHW
-
PAK1_HUMAN
A:
[270-523]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
-
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
--
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
-
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
----
G
M
D
G
-
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
-
L
-
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
------------------------------------------------------------------------
2
PsiBlast_PDB
71.40
35%
-98
- C1 -
-
5KBQ
1
PAK1_HUMAN
A:
[17-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
-
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
-
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
----
G
M
D
G
-
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
-
L
-
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
------------------------------------------------------------------------
4
PsiBlast_PDB
71.28
34%
-93
- C1 -
-
4O0R
1
PAK1_HUMAN
A:
[22-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
-
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
-
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
----
G
M
D
G
-
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
-
L
-
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
------------------------------------------------------------------------
12
PsiBlast_PDB
71.20
34%
-108
- C1 -
-
4ZLO
2
PAK1_HUMAN
A:
[22-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
-
G
Q
--
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
------
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
-
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
----
G
M
D
G
-
S
V
K
L
T
D
F
G
-----------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
-
L
-
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
------------------------------------------------------------------------
10
PsiBlast_PDB
71.08
34%
-112
- C1 -
-
4ZJI
1
PAK1_HUMAN
A:
[24-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
-
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
------
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
-
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
----
G
M
D
G
-
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
-
L
-
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
------------------------------------------------------------------------
52
Fugue
70.73
20%
-33
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
-
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
--
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
P
M
G
E
D
W
----
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
----
D
D
D
G
-
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
--
G
Q
T
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
-
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
----
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
GFRDG
S
C
D
G
L
R
T
H
P
L
F
R
D
IS
W
R
Q
L
E
A
GMLTPP
F
V
P
D
SRTVYAKNGAFSG
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
SGTC
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
VWRP
5
PsiBlast_PDB
68.74
34%
-85
- C1 -
-
4O0T
1
PAK1_HUMAN
A:
[22-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
-
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
-
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
----
G
M
D
G
-
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
-
L
-
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
------------------------------------------------------------------------
19
PsiBlast_PDB
66.84
34%
-93
- C1 -
-
4ZY6
1
PAK1_HUMAN
A:
[23-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
-
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---------
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
-
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
----
G
M
D
G
-
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
-
L
-
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
------------------------------------------------------------------------
18
PsiBlast_PDB
66.25
34%
-90
- C1 -
-
4ZY4
1
PAK1_HUMAN
A:
[23-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
-
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
-
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
----
G
M
D
G
-
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
-
L
-
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
------------------------------------------------------------------------
53
Fugue
62.48
25%
-65
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
--
R
L
E
V
F
------
R
A
E
E
L
M
A
C
A
G
L
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
G
C
----
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
----
S
S
D
G
S
H
A
A
L
C
D
F
G
H
A
----------
V
C
L
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
-
L
-
G
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
----
Q
F
F
R
G
P
L
C
L
K
I
A
S
E
P
P
P
-
V
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
-----
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
GGLKSPWR
G
E
Y
K
E
P
RHP----------------------------------------------------
36
HHSearch
62.31
26%
-80
- C1 -
-
5JZN
1
DCLK1_HUMAN
A:
[19-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
Y
K
V
G
-
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
--
K
K
S
K
C
R
G
K
E
H
M
I
Q
N
E
V
S
I
L
R
R
V
K
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
N
K
----
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
D
G
S
K
-
S
L
K
L
G
D
F
G
L
A
T
I
V
D
G
P
-----
L
Y
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
-
A
E
T
G
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
G
S
--
D
Q
--
E
V
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
-----
S
A
V
Q
V
L
E
H
P
W
V
N
-------------------------------------------------------------------------