@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_26_1710: (2018-03-10 )
MLAHPILASEDDEEYVIRVIFCLPALLDAYFDAVETICAEPSPPPESKTRADILHLTIQQRLLILGRVPPSTFRHFDEVSGTETEDKELPKLIDQLRHVFLENKVDIGPQALLWRKRSLSLARECSDHMNRCRVRFSLGRKVRRELVAFGSAPYAFSMISFGLIVIFSCSALVIIPALQAPLASGLAVGCVACVLLVLSASLVSFNFFTAVRSLHILYSQLFHEYLIAGGSPSDILLNSLQEPCFKPRGKDGPRDSGTKRLEMGRETKTGYYTIPYGGENRIGYIEGKQLNAQVVMIAFDSNYQITWWNNAAEVMTGFLQDGCIGKPLNELVQCFNDEDVCSLIKNTRRGNLLKIKLRSLTAAPTTLSTVVAPILNCDSKPIGNVLICANSLDNLREYRIYMHNYQVSETIGALSFLSERSSLSHEDSTLVNSLSRFVKNGLANHVETLAREMESDWDWTSVEQLLGRALGQRIGLHEVIVDPLFPPTLCVNPDVAKTFGTVVGLANGRCTVTLQMLNLTGNVFSLAVTVLLGPKCRPWDQAQLEQQLEQLLRSTAGSVYLLEERVVLHFPCQVAPILDDGDEGDANPNSDQALQITQARAIINCTVNVVTAITNMVDQHNLSLILLKTMFVSLASVRERSDLEKRLSARPCDVDVIICDSEWLSSSRDLLMNNDHGAMVIPLIDAQMPVPADVQHAICMPLVRRDVQQLILEVGKAVSMKKNAISAREERERILTLRQDSPWTRGKLLGRGSYGAVYEATSDLTGGKMAVKMFYFSQNVESSISTLLNEVSIMCSLNHPNIVHYFHCERKDNNVSLFMELCEASLTDIIVGRRQKPAHLSVVQIIRQVLTAIAYLHSRGIAHRDVKPQNILLKGETVKLTDFGTAIQGNAGKEVRGTFRYMAPEVYKGDPHSLSCDIWSIGCLVCELFACPTPFMENSSLLGEMTSTVDYLTRVPQNPVLIDFLEKCFQLDPERRWGAGDLLMHPLLSGNAAASSLVKLETIFDAKHSNPLDPSSQSVFSLRSA
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650----.........660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......---780........790.......800.......810.......820..-.-.....830..---..-...840.......850.......860.......870...----.-...880......----.890---.----....----...900......---.910........920.......930.......940.......950-------.---------.----------------------------.-----.---.------..-----..-----960.......970......-----.980.......990.......1000......1010......1020..-------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLAHPILASEDD
E
E
Y
V
I
R
V
I
F
C
L
P
A
L
L
D
A
Y
F
D
A
V
E
T
I
CAEPSPPPESKT
R
A
D
I
L
H
L
T
I
Q
Q
R
L
L
ILGRVP
P
S
T
F
R
H
F
D
EVSGTET
E
D
K
E
L
P
K
L
I
D
Q
L
R
H
V
F
L
ENKVDIG
P
Q
A
L
L
W
R
K
R
S
L
S
L
A
R
E
C
S
D
H
M
N
R
C
R
V
R
F
S
L
G
R
K
V
R
R
E
L
V
A
FGSA
P
Y
A
F
S
M
I
S
F
G
L
I
V
IFSC
S
A
L
V
I
IP
A
L
Q
A
P
L
A
S
G
L
A
V
G
C
V
A
C
V
L
L
V
L
S
A
S
L
V
S
F
N
F
F
T
A
V
R
S
L
H
I
L
Y
S
Q
L
F
H
E
Y
LIAGG
S
P
S
D
I
L
L
N
S
L
QEPCFKPRGKDGPRDSGT
K
R
L
EMGRETKT
G
Y
Y
TIPYGGEN
R
I
G
Y
I
EGKQL
N
A
Q
V
V
M
I
A
FDS
N
Y
Q
I
T
W
WN
N
A
A
E
V
M
T
G
F
L
QDGCIG
K
P
L
N
E
L
V
Q
CF
N
D
E
D
V
C
S
L
I
K
NTRRG
N
L
L
K
I
K
L
RSLTAAP
T
T
L
S
T
V
V
A
P
I
LNCDSKPI
G
N
V
L
I
CANS
L
D
N
L
R
E
Y
R
I
Y
M
HNY
Q
V
S
E
T
I
G
A
L
S
F
L
S
E
R
SSLSH
E
D
S
T
L
V
N
S
L
S
R
F
V
K
N
G
L
A
N
H
V
E
T
L
A
R
E
M
ESDWD
W
T
S
V
E
Q
L
L
G
R
A
L
G
Q
RI
G
L
H
E
V
I
VDPLFPPTLCVN
P
D
V
A
K
T
F
G
T
V
VGLANG
R
C
T
V
T
L
Q
M
LNLTG
N
V
F
S
L
A
V
T
V
L
LGPKCRPW
D
Q
A
Q
L
E
Q
Q
L
E
Q
L
L
R
STAG
S
V
Y
L
L
EE
R
V
V
L
HFPCQVAPILDDGDEGDANPNSD
Q
A
L
Q
I
TQ
A
R
A
I
I
N
C
T
V
N
V
V
T
A
I
T
N
M
V
D
QHN
L
S
L
I
L
L
K
T
M
F
V
S
L
A
S
V
R
E
R
S
D
L
E
K
R
LSAR------PC
D
V
D
V
I
I
C
D
S
E
WLSSSR
D
L
L
MNNDH
G
A
M
V
I
P
L
IDAQMPV
P
A
D
V
Q
H
A
I
C
M
P
L
V
R
R
D
V
Q
Q
L
I
L
E
V
G
K
A
VS
M
K
K
N
AI
S
A
R
E
E
R
E
R
I
L
TLRQDSPWTRG
K
L
LGRGSYG
A
V
Y
E
ATSDLTGG
K
M
A
V
K
M
F
Y
FSQ
N
---
V
E
-
S
S
I
S
T
L
L
N
E
V
S
I
M
C
SLNHP
N
I
V
H
Y
F
H
CERKDN
N
V
S
L
F
M
E
-
L
C
E
-
A
-
S
L
T
D
I
I
VGRR---QK-PA
H
L
S
V
V
Q
I
I
R
Q
V
L
T
A
I
A
Y
L
H
SRGIAHRDVKPQ
N
I
L
L
KG----
E
-
T
V
K
L
TDFGTAIQ----GNA----G----KEV
R
----
G
T
F
RYMAPEVYK---GDP-HSLS
C
D
I
W
S
I
G
C
L
V
C
E
L
FACPTPFMEN
S
S
L
L
G
E
M
T
S
T
V
D
---------
Y
---------
L
----------------------------
T
-----R---V------PQ-----N
P
-----
V
L
I
D
F
L
E
K
C
FQLDPERRWG-----A
G
D
L
L
M
H
P
LLSGN
A
A
A
S
S
L
V
K
L
E
T
I
FDAKHSNPLDPSSQS
V
F
SLRSA-------------------------------------
29
HHSearch
73.00
27%
-47
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[3-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
---
D
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
S
D
K
K
L
T
L
V
F
E
-
F
C
D
-
Q
-
D
L
K
K
Y
F
D
S
C
N
---
G
D
-
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N---
G
-
E
L
K
L
A
N
F
G
L
A
R
A
----
F
G
I
----
P
VRCY
S
A
E
V
----
V
T
L
W
Y
R
P
P
D
V
L
F
---
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
LGTPTEEQ
W
PSMTKLPD
Y
K
P
Y
P
MYPATTSL-----------------
V
-----
N
---
V
VP----
K
L
-----
N
A
-----
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
-----
A
E
E
A
L
Q
H
P
Y
F
S
D
F
-----------------------------------------------------------------------
31
HHSearch
72.58
28%
-70
- C1 -
-
4BGQ
3
CDKL5_HUMAN
A:
[12-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
-----------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
R
R
G
K
L
Y
L
V
F
E
-
Y
V
E
-
K
-
N
M
L
E
L
L
E
E
M
P
---
N
G
-
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N---
D
-
V
L
K
L
C
D
F
G
F
A
R
N
----
L
S
E
------------------
T
R
W
Y
R
S
P
E
L
L
L
---
G
A
P
-
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
S
E
I
D
-
Q
L
F
T
I
Q
K
---------
V
---------
L
GPLP
S
E
Q
M
K
L
F
Y
S
NPRFHGLRFPAV
N
H
P
Q
-----
S
---
L
E
R
R
Y
LG
I
L
-----
N
S
-----
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
-----
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
-----------------------------------------------------------------------
12
PsiBlast_PDB
71.24
32%
-42
- C1 -
-
4O0R
1
PAK1_HUMAN
A:
[22-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
---
P
K
-
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
-
G
-
S
L
T
D
V
V
T
E
T
C
---
M
D
-
E
G
Q
I
A
A
V
--
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
----
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
PE
Q
S
K
----
R
----
S
E
M
V
----
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-
N
E
N
P
L
R
A
L
Y
L
I
A
T
---------
N
---------
G
----------------------------
T
-----
P
---
E
------
L
Q
-----
N
P
EKLS
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
-----
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
--------------------------------------------------------------
15
PsiBlast_PDB
71.02
31%
-47
- C1 -
-
3Q53
1
PAK1_HUMAN
A:
[23-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
---
P
K
-
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
-
G
-
S
L
T
D
V
V
T
E
T
C
---
M
D
-
E
G
Q
I
A
A
V
--
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
----
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
----
I
T
P
----
E
----
Q
S
K
R
STMV
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-
N
E
N
P
L
R
A
L
Y
L
I
A
T
---------
N
---------
G
----------------------------
T
-----
P
---
E
------
L
Q
-----
N
P
EKL
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
-----
A
K
E
L
I
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
--------------------------------------------------------------
13
PsiBlast_PDB
70.81
32%
-45
- C1 -
-
4O0T
1
PAK1_HUMAN
A:
[22-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
---
P
K
-
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
-
G
-
S
L
T
D
V
V
T
E
T
C
---
M
D
-
E
G
Q
I
A
A
V
--
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
----
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
PE
Q
S
K
----
R
----
S
E
M
V
----
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-
N
E
N
P
L
R
A
L
Y
L
I
A
T
---------
N
---------
G
----------------------------
T
-----
P
---
E
------
L
Q
-----
N
P
EKLS
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
-----
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
--------------------------------------------------------------
7
PsiBlast_PDB
70.35
32%
-48
- C1 -
-
4DAW
-
PAK1_HUMAN
A:
[22-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
---
P
K
-
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
-
G
-
S
L
T
D
V
V
T
E
T
C
---
M
D
-
E
G
Q
I
A
A
V
--
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
----
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
----
I
T
P
----
E
----
Q
S
K
R
STMV
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-
N
E
N
P
L
R
A
L
Y
L
I
A
T
---------
N
---------
G
----------------------------
T
-----
P
---
E
------
L
Q
-----
N
P
EKL
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
-----
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
--------------------------------------------------------------
11
PsiBlast_PDB
69.31
32%
-41
- C1 -
-
1YHV
-
?
A:
[270-533]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
---
P
K
-
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
-
G
-
S
L
T
D
V
V
T
E
T
C
---
M
D
-
E
G
Q
I
A
A
V
--
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
----
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
PE
Q
S
K
----
R
----
S
E
M
V
----
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-
N
E
N
P
L
R
A
L
Y
L
I
A
T
---------
N
---------
G
----------------------------
T
-----
P
---
E
------
L
Q
-----
N
P
EKLS
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
-----
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
--------------------------------------------------------------
1
PsiBlast_PDB
68.90
32%
-58
- C1 -
-
4ZJI
1
PAK1_HUMAN
A:
[24-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---------
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
-
G
-
S
L
T
D
V
V
T
E
T
C
---
M
D
-
E
G
Q
I
A
A
V
--
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
----
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
----
I
T
P
-------------TMV-
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-
N
E
N
P
L
R
A
L
Y
L
I
A
T
---------
N
---------
G
----------------------------
T
-----
P
---
E
------
L
Q
-----
N
P
EKLS
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
-----
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
--------------------------------------------------------------
43
HHSearch
68.89
33%
-63
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[94-356]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
-
F
L
E
G
G
-
A
L
T
D
I
V
T
H
T
-----
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D---
G
-
R
V
K
L
S
D
F
G
F
C
A
Q
----
V
S
K
----
E
VPRR
K
S
L
V
----
G
T
P
Y
W
M
A
P
E
L
I
S
---
R
L
P
-
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
-
K
A
M
K
M
I
R
D
---------
N
---------
L
----------------------------
P
PRLKN
L
---
H
------
K
V
-----
S
P
-----
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
-----
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
I
-----------------------------------------------------------------
8
PsiBlast_PDB
68.87
32%
-44
- C1 -
-
5DFP
2
PAK1_HUMAN
A:
[22-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
---
P
K
-
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
-
G
-
S
L
T
D
V
V
T
E
T
C
---
M
D
-
E
G
Q
I
A
A
V
--
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
----
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
----
I
T
P
----
E
----
Q
S
K
R
STMV
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-
N
E
N
P
L
R
A
L
Y
L
I
A
T
---------
N
---------
G
----------------------------
T
-----
P
---
E
------
L
Q
-----
N
P
EKL
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
-----
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
--------------------------------------------------------------
9
PsiBlast_PDB
68.02
32%
-46
- C1 -
-
5DEY
1
PAK1_HUMAN
A:
[22-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
---
P
K
-
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
-
G
-
S
L
T
D
V
V
T
E
T
C
---
M
D
-
E
G
Q
I
A
A
V
--
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
----
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
PE
Q
S
K
----
R
----
S
E
M
V
----
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-
N
E
N
P
L
R
A
L
Y
L
I
A
T
---------
N
---------
G
----------------------------
T
-----
P
---
E
------
L
Q
-----
N
P
EKLS
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
-----
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
--------------------------------------------------------------
17
PsiBlast_PDB
67.97
32%
-41
- C1 -
-
1YHW
-
PAK1_HUMAN
A:
[270-533]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
---
P
K
-
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
-
G
-
S
L
T
D
V
V
T
E
T
C
---
M
D
-
E
G
Q
I
A
A
V
--
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
----
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
----
I
T
P
----
E
----
Q
S
K
R
STMV
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-
N
E
N
P
L
R
A
L
Y
L
I
A
T
---------
N
---------
G
----------------------------
T
-----
P
---
E
------
L
Q
-----
N
P
EKLS
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
-----
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
--------------------------------------------------------------
18
PsiBlast_PDB
67.85
32%
-39
- C1 -
-
5KBQ
1
PAK1_HUMAN
A:
[17-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
---
P
K
-
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
-
G
-
S
L
T
D
V
V
T
E
T
C
---
M
D
-
E
G
Q
I
A
A
V
--
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
----
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
PE
Q
S
K
----
R
----
S
E
M
V
----
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-
N
E
N
P
L
R
A
L
Y
L
I
A
T
---------
N
---------
G
----------------------------
T
-----
P
---
E
------
L
Q
-----
N
P
EKLS
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
-----
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
--------------------------------------------------------------
6
PsiBlast_PDB
67.70
32%
-45
- C1 -
-
3FY0
1
PAK1_HUMAN
A:
[22-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
---
P
K
-
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
-
G
-
S
L
T
D
V
V
T
E
T
C
---
M
D
-
E
G
Q
I
A
A
V
--
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
----
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
----
I
T
P
----
E
----
Q
S
K
R
STMV
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-
N
E
N
P
L
R
A
L
Y
L
I
A
T
---------
N
---------
G
----------------------------
T
-----
P
---
E
------
L
Q
-----
N
P
EKL
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
-----
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
--------------------------------------------------------------
5
PsiBlast_PDB
67.68
32%
-43
- C1 -
-
3FXZ
1
?
A:
[22-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
---
P
K
-
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
-
G
-
S
L
T
D
V
V
T
E
T
C
---
M
D
-
E
G
Q
I
A
A
V
--
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
----
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
----
I
T
P
----
E
----
Q
S
K
R
STMV
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-
N
E
N
P
L
R
A
L
Y
L
I
A
T
---------
N
---------
G
----------------------------
T
-----
P
---
E
------
L
Q
-----
N
P
EKL
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
-----
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
--------------------------------------------------------------
4
PsiBlast_PDB
67.09
32%
-42
- C1 -
-
4EQC
1
PAK1_HUMAN
A:
[26-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
---
P
K
-
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
-
G
-
S
L
T
D
V
V
T
E
T
C
---
M
D
-
E
G
Q
I
A
A
V
--
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
----
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
----
I
T
P
----
E
----
Q
S
K
R
STMV
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-
N
E
N
P
L
R
A
L
Y
L
I
A
T
---------
N
---------
G
----------------------------
T
-----
P
---
E
------
L
Q
-----
N
P
EKL
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
-----
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
--------------------------------------------------------------
45
HHSearch
66.84
27%
-40
- C1 -
-
1U5R
1
TAOK2_RAT
A:
[54-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q--
S
N
-
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
H
T
A
W
L
V
M
E
-
Y
C
L
-
G
-
S
A
S
D
L
L
E
V
H
K
---
K
P
-
L
Q
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
P---
G
-
L
V
K
L
G
D
F
G
S
A
S
I
----
M
A
P
----
A
----
N
S
F
V
----
G
T
P
Y
W
M
A
P
E
V
I
L
AM
D
E
G
Q
-
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
S
-
A
L
Y
H
I
A
Q
---------
N
---------
E
----------------------------
S
P----
A
LQS
G
------
H
W
-----
S
E
-----
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
-----
S
E
V
L
L
K
H
R
F
V
L
R
E
R
P
P
T
V
I
M
D
L
--------------------------------------------------------------
10
PsiBlast_PDB
66.64
32%
-40
- C1 -
-
5DEW
1
PAK1_HUMAN
A:
[22-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
---
P
K
-
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
-
G
-
S
L
T
D
V
V
T
E
T
C
---
M
D
-
E
G
Q
I
A
A
V
--
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
----
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
PE
Q
S
K
----
R
----
S
E
M
V
----
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-
N
E
N
P
L
R
A
L
Y
L
I
A
T
---------
N
---------
G
----------------------------
T
-----
P
---
E
------
L
Q
-----
N
P
EKLS
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
-----
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
--------------------------------------------------------------
51
Fugue
66.59
17%
14
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
TPDD
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
V
T
K
N
T
---
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
---
K
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
-
L
M
N
-
G
G
D
L
K
F
H
I
Y
H
M
G
---
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
----
H
G
H
I
R
I
S
D
L
G
L
A
V
H
----
V
P
E
----
G
----
Q
T
I
K
G
RV-
G
T
V
G
Y
M
A
P
E
V
V
K
---
N
E
R
-
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
---------
V
---------
K
----------------------------
E
-----
V
---
P
------
E
E
Y
S
ERF
S
P
-----
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
CRGGS
A
R
E
V
K
E
H
P
L
F
K
K
-------
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
ATGSVP
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
VFGLDGS
32
HHSearch
63.82
29%
-40
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[24-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
G
-
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
-
F
M
D
G
A
-
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
KENS
A
-
P
V
K
L
G
G
F
G
V
A
I
Q
----
L
G
E
SG
L
V
A
----
G
G
R
V
----
G
T
P
H
F
M
A
P
E
V
V
K
---
R
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
--
L
F
E
G
I
I
K
---------
G
---------
K
----------------------------
Y
-----
K
M--
N
PRQWS-
H
I
-----
S
E
-----
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
--------------------------------------------------------------------
3
PsiBlast_PDB
63.09
32%
-46
- C1 -
-
4ZLO
2
PAK1_HUMAN
A:
[22-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
--
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
--------
K
-
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
-
G
-
S
L
T
D
V
V
T
E
T
C
---
M
D
-
E
G
Q
I
A
A
V
--
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
----
D
G
S
V
K
L
T
D
F
G
---------------------
S
K
R
STMV
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-
N
E
N
P
L
R
A
L
Y
L
I
A
T
---------
N
---------
G
----------------------------
T
-----
P
---
E
------
L
Q
-----
N
P
EKL
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
-----
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
--------------------------------------------------------------