@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_26_2060: (2018-03-10 )
MGCKSFKGRLGPLNRGDDGDPNDQLPSGKKGKALNNFNGVAFRGFGVGAPAHNNGKAGGNSIAAFRPDGETANAYYKYVMELRRVAVAQGILPSVTDDAIVALDATGDKDGTLAGTKGATDKAFHRSTNDDSTNASGQHVSPPARTLTVYQLQPLAGDTCIAKGMYSEVHLAHLSVFTGLSEETVNATLPRNAPARRGNTDGAAACAAGRDRSSFSFGGDVNSTKSLNSGRDIIDATSAHDANTIVGPVSAPAATPTVAPTCAAVAHYIIAMKEFFLHSGYTSSFVLEQVCLEVRRWARLSTYCPRLLRCYQLEYVFADGIFMTVPEASYQFFPGRENHGGNGGAAAGGLSASGNLATGTAGRAEDHRKPLSGSGAHLLASLLNRHSHSSPKSQQQNAVGGTPRKLRLYLEYAKHGTLRGFQVKEMPSRFERRRLHELTARAYMRDVLLALLQMHDRGEMQYDLCAKAVFLHRPIQSVYYTYFPAYISDLPTGDLTSVTPAQLGKALGLLDPPPGSLDLHRAPPLTSDSTSQKRKNFENEPINGTPSPLLKHRRGVLGEQRKNTSSSVQRTGKAAGVEAHRTHNVSMLAHNTSCMPQVPAMDANPKESNETLGGQGMAAVQACEQRNGNTVTIESGNTAEVAHDNNASFTSVQEVGSYESPLRAASMTETGFRGGLVASGSPSTTHASSGTHTLSKQNRANSVSAFGISEASGDDGTHQLRLHETYLRFMSEFEFMHTHEGDGLPFPSPHDGVRGQADAEMLASTMASEEALKAPPMRVVPLQNTSLGGVAILSPDHYVVKPIETPLHDLRGRLPILLPPSTTHAAFFCGGPQHQRQVTHKSPSSSAPMVVGSPSTEPFCAPQTLSSGTTKLDAVGSLGRCRGGAPLVKLNHTSLIRRALGFADSRRLEDVPVHKYVTVTHAAPEVLHRRLFSTASDIYAFAMTFVELVSDGGVIMEECLPANLPKPLTRRDKDMYDARLSENLNKWYQARITALLHNHDAAGKKERPESASPHAGSIAVRLPPHLSDECKKMLRWCLQPDPAKRPTAAELLRSRYFMLGDWIAAPSVAEAEGKTVQMPEAPWMPSISFDAAAKAAGLPVLSAKR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.........150.......160.......170.......180...--------....190.......200.......210.......220.......230........240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.....--..380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560-.........570.......580..-.....590.......600.......610.......620.....--..630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780...----....790..----.....800.......810.......820.......830......----.840.......850.....-..860.......870.......880.--......890.......900....----...910.......920.......-930----........940.......950.......960..----.....970.......980----.........990.......1000....-.....1010......1020......1030......1040.--..-----..------.-1050......1060......1070......1080......1090......1100..--
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGCKSFKGRLGPLNRGDDGDPNDQLPSGKKGKALNNFN
G
V
A
F
R
G
FGVGAPAHNNGKAGGNS
I
A
A
FRPDGET
A
N
A
Y
Y
K
Y
V
M
E
L
R
R
V
A
V
A
QGILPSVTD
D
A
I
V
A
L
DATGDKDGTLAGTKGATDK
A
F
HRSTNDDSTNASGQHV--SPP
A
R
T
L
T
V
Y
Q
LQPLAG
D
T
C
I
A
KG
M
Y
S
E
V
H
L
A
H
L
S
V
FTGLSEETV--------NATLPRNAPARRGNTDGAAACAAGRDRSSFSFGGDVNSTKSLNSGR-DIIDATSAHDAN
T
I
VGPVSAPAATPTV
A
P
T
C
A
A
V
A
H
Y
I
I
A
M
K
E
F
F
LHSGY
T
S
S
F
V
L
E
Q
V
C
L
E
V
R
R
W
A
R
L
S
T
Y
C
P
R
L
L
R
C
Y
Q
L
E
Y
V
FAD
G
I
F
M
TVPEASYQFFPGRENHGGNGGAAAGGLSASGNLATGTAGRA
E
D
HRKPLSGS
G
A
H
--
L
L
A
S
L
L
N
R
HSHSSP
K
S
Q
Q
QNAVGGTP
R
K
L
R
L
Y
L
E
YAKHGTLRGF
Q
V
K
E
M
P
S
R
F
E
R
R
R
L
H
E
L
T
A
R
A
Y
M
R
D
V
L
L
A
L
L
Q
MHDRG
E
M
Q
Y
D
L
C
A
K
A
V
F
LHR
P
I
Q
S
V
Y
Y
T
Y
F
P
A
Y
I
SDLPTGDLTSV
T
P
A
Q
L
G
K
A
LGLLDPPPGSLDLHRAPPLTSDS
T
S
Q
K
RKNFENEPINGT
P
S
P
L
L
K
H
R
R
G
VLGEQ---RKN
T
S
S
S
V
Q
RTGKAAG
V
E
A
HRTH
N
-
V
S
M
L
AHNTSCMPQVPAMDANPKESNETLGG
Q
G
M
A
A
V
Q
A
C
E
QRN--G
N
T
V
T
IESG
N
T
A
E
V
AHDNNAS
F
T
S
V
Q
E
VGSYESPLRAASMTETGFRG
G
L
VASGSPSTTHASSGTHTLSKQNRANSV
S
A
F
GISEASGDDG
T
H
Q
L
R
L
H
E
T
Y
L
R
F
M
S
E
F
E
F
M
HTHEGDGLPFPSPHDGVRGQ
A
D
A
E
M
L
A
S
T
M
AS
E
E
ALKAPP
M
R
V
V
PLQNT----SLG
G
V
A
I
LS----PD
H
Y
V
V
K
P
I
ET
P
L
H
D
L
RGR
L
P
I
L
LPPSTT
H
A
A
F
F
CGG
P
Q
H
Q
R
QV----THKSPSSSA
P
M
V
VGSPSTE-PFCAPQTLSSGTT
K
L
D
AVGSLGRCRG--GA
P
L
V
K
L
N
H
T
S
L
I
R
R
A
LGFADSR----RLEDVPV
H
K
Y
V
T
VTHA
A
P
E
V
L
H
R
-
R
-
L
----
F
S
T
A
S
D
I
Y
A
F
A
M
T
F
V
E
L
VSDG
G
V
I
M
E
E
CLPANL----PKPLTRR
D
K
D
M
Y
D
A
R
L
------
S
E
N
L
N
K
W
Y
Q
A
R
I
T
A
L
L
HNHD---AAGK-KERPESASPHA
G
S
I
A
V
RLPPH
L
S
D
E
C
K
K
M
L
R
W
CLQPDPAK--RP-----
T
A
------
A
-
E
L
L
R
S
R
Y
F
M
L
GDWIAAPSVAEAEG
K
T
V
QMPEAPWMPSISFDAAAKAAGLPVLSAKR--
26
Fugue
57.62
19%
59
* C2 *
-
4NUZ
-
?
A:
[1-892]
------------------
M
K
I
P
E
K
I
P
---
M
K
P
L
H
G
P
L
Y
G
G
Y
F
R
T
W
H
-
D
K
T
S
D
P
T
E
K
D
K
V
N
S
M
G
E
---------------------------
L
P
K
E
V
D
L
A
F
I
F
H
D
W
T
--
K
D
Y
S
L
F
W
K
E
L
A
T
K
-------
H
V
P
K
L
N
K
Q
G
T
R
V
I
R
T
I
P
W
R
F
L
A
G
G
D
N
S
G
I
A
E
D
T
----
S
K
Y
P
N
T
P
E
G
N
K
A
L
A
K
A
I
V
D
E
Y
V
YKYNLD
G
L
D
V
Q
V
E
H
D
S
I
P
K
V
D
K
K
E
D
--
T
A
G
V
E
R
S
I
Q
V
F
E
E
I
G
K
L
I
G
P
K
G
V
D
K
S
R
L
F
I
M
D
S
T
Y
M
A
D
K
N
------------
P
L
I
E
R
G
A
P
Y
I
N
L
L
L
V
Q
V
Y
G
S
Q
G
E
K
G
G
W
E
P
V
S
N
R
P
E
K
T
M
E
E
R
W
Q
G
Y
S
K
Y
I
R
P
E
Q
--
Y
M
I
G
F
S
F
Y
E
E
-
N
A
Q
E
G
N
L
W
Y
D
I
N
S
R
K
D
E
D
K
A
N
G
---------
I
N
T
D
I
T
G
T
R
A
E
R
Y
A
R
W
Q
P
K
T
G
-
G
V
K
G
G
I
F
S
Y
A
I
D
R
-----------
D
G
V
A
H
Q
P
K
K
Y
A
-----
K
K
D
A
T
D
N
I
F
--------
H
S
D
Y
S
V
S
K
A
L
K
T
V
M
L
K
D
-------------
K
S
Y
D
L
I
D
E
--------------------
K
D
F
P
D
K
A
L
R
E
A
V
M
A
Q
V
G
T
R
K
G
D
L
E
R
F
N
G
T
L
R
L
D
N
-
P
A
I
Q
S
L
E
G
L
N
K
F
K
K
L
A
Q
L
D
L
I
G
-
L
S
R
I
T
K
L
D
R
S
V
L
P
A
N
M
K
P
G
K
D
T
L
E
T
V
L
E
T
Y
K
K
D
N
K
E
E
P
A
T
I
P
P
V
S
L
K
V
S
G
L
T
G
L
K
E
L
D
L
S
G
F
D
----
R
E
T
L
A
G
L
D
A
A
T
L
T
S
L
E
K
V
D
IS
G
N
K
L
D
L
A
P
G
T
E
N
R
Q
I
F
D
T
M
L
S
T
I
S
N
H
-
V
G
S
N
E
Q
T
V
K
F
D
K
Q
K
P
T
G
H
Y
P
D
---
T
Y
G
K
T
S
L
R
L
P
V
A
N
E
K
V
D
L
Q
S
Q
L
----
L
F
G
T
V
T
N
Q
G
-----------
T
L
I
N
S
E
A
D
Y
K
A
Y
Q
N
H
K
I
A
G
R
S
F
V
D
---------------
S
N
Y
H
Y
N
N
F
K
V
S
Y
E
N
Y
T
V
K
V
T
D
S
----
T
L
G
T
T
---
T
----
D
K
T
L
A
T
D
K
E
E
T
Y
K
V
D
F
F
S
--
P
A
D
K
T
K
A
V
H
T
A
K
V
I
V
G
D
E
K
T
M
M
--------
V
N
L
A
E
G
A
T
V
I
G
G
S
A
D
---
P
V
N
A
R
K
V
F
D
G
Q
L
G
S
E
T
D
N
I
S
L
G
W
D
S
K
--
Q
S
I
I
F
K
L
K
E
D
G
L
I
K
H
W
R
F
F
N
D
S
A
----
R
N
P
E
-------
T
T
N
K
P
I
Q
E
A
S
L
Q
-
I
-
F
----
N
I
K
D
Y
N
L
D
N
L
L
E
N
P
N
K
F
D
D
E
K
Y
W
I
T
V
D
T
Y
S
A
Q
G
----
E
R
A
------
T
A
F
S
N
T
L
------
N
N
I
T
S
K
Y
W
R
V
V
F
D
T
-----------
K
G
-
D
R
Y
S
S
P
V
V
P
E
L
Q
I
L
G
Y
P
L
P
N
--
A
D
T
I
M
K
T
V
T
T
A
K
E
L
S
Q
Q
K
--
D
K
----------------------------
F
S
Q
K
M
L
D
E
L
K
I
K
E
M
A
L
E
T
S
--
L
N
S
K
I
F
D
V
T
A
I
N
A
N
A
G
V
L
K
D
C
I
EK
40
HHSearch
44.59
20%
-134
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[145-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
---------
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
----------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
-
E
-
P
----
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
-
L
P
F
Y
G
T
K
E
----------------
R
L
F
-----------
E
G
I
---
I
K
-------
G
K
Y
------------
K
---------
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
-----
T
V
------
Y
-
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
-------------------------------------------
47
HHSearch
43.42
20%
-124
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[145-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
---------
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
----------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
-
E
-
P
----
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
-
L
P
F
Y
G
T
K
E
----------------
R
L
F
-----------
E
G
I
---
I
--------
K
G
K
Y
-----------
K
---------
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
-----
T
V
------
Y
-
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
-------------------------------------------
2
PsiBlast_PDB
42.53
66%
-187
- C3 -
-
3DAK
-
OXSR1_HUMAN
A:
[260-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
--
R
P
-----
T
A
------
A
-
E
L
L
R
H
K
F
F
--------------------------------------------------
3
PsiBlast_PDB
41.81
62%
-189
- C3 -
-
5DBX
-
STK39_MOUSE
A:
[261-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
--
R
P
-----
T
A
------
A
-
E
L
L
K
-
K
F
F
--------------------------------------------------
52
HHSearch
41.39
21%
-122
- C1 -
-
3TXO
1
A:
[139-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
------------
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
-------------------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
-
M
-
L
----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
-
A
P
F
E
A
E
N
E
D
---------------
D
L
F
-----------
E
A
I
---
L
--------
N
D
------------------------
E
V
V
Y
P
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
--
R
L
-----
G
S
LTQGG
E
H
-
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
---
L
N
H
R
Q
------
I
E
P
P
F
R
P
R
I
--------------------
1
PsiBlast_PDB
40.72
66%
-181
- C3 -
-
2VWI
-
OXSR1_HUMAN
A:
[265-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
--
R
P
-----
T
A
------
A
-
E
L
L
R
H
K
F
F
--------------------------------------------------
43
HHSearch
40.64
14%
-42
- C1 -
-
3V8S
1
ROCK1_HUMAN
D:
[183-354]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
------------
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
-
V
--------
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
-
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
Y
A
D
S
L
V
G
---------------
T
-----------
Y
S
K
I
M
N
H
K
--------
N
S
L
-----------------------
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
-----
G
V
------
E
-
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
---
E
T
L
R
D
------
T
V
A
P
V
V
P
D
L
--------------------
45
HHSearch
39.75
17%
-88
- C1 -
-
4Y85
1
M3K8_HUMAN
B:
[180-327]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
H
S
-
K
K
V
I
H
H
D
I
K
P
S
N
I
V
F
M
S
T
-------------
K
A
V
L
V
D
F
G
L
S
V
Q
M
T
E
D
-
V
Y
---------
F
P
K
D
L
R
G
T
E
I
Y
M
S
P
E
V
I
L
C
-
R
-
G
----
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
-
P
P
W
V
K
R
Y
P
R
S
A
---------------
Y
-----------
P
S
Y
L
Y
I
I
H
-------
K
Q
A
---------------------
P
P
L
E
D
I
A
D
D
C
S
P
G
M
R
E
L
I
E
A
S
L
E
R
N
P
N
H
--
R
P
-----
R
A
------
A
-
D
L
L
K
H
E
A
L
N
P
------------------------------------------------
54
HHSearch
39.56
16%
-89
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[129-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
--------
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
-----------
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
-
E
-
P
----
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
-
S
P
F
L
G
D
T
K
Q
E
---------------
T
L
-----------
A
N
V
S
A
V
N
--------
Y
E
-----------------------
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
------
Q
-
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
-------------------------------------------
37
HHSearch
39.56
21%
-88
* C1 *
-
4XBR
1
PAK4_HUMAN
A:
[205-354]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
H
A
-
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
------------
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
----------
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
-
P
----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
-
P
P
Y
F
N
E
P
P
L
K
---------------
A
M
-----------
K
M
I
R
D
N
L
--------
P
P
------------------------
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
A
-----
T
A
------
A
-
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
-------------------------------------------
49
HHSearch
38.66
17%
-82
- C1 -
-
5IU2
1
M3K8_HUMAN
B:
[180-326]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
H
S
-
K
K
V
I
H
H
D
I
K
P
S
N
I
V
F
M
S
T
-------------
K
A
V
L
V
D
F
G
L
S
V
Q
M
T
E
D
-
V
Y
---------
F
P
K
D
L
R
G
T
E
I
Y
M
S
P
E
V
I
L
C
-
R
-
G
----
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
-
P
P
W
V
K
R
Y
P
R
S
---------------
A
Y
-----------
P
S
Y
L
Y
I
I
H
-------
K
Q
A
---------------------
P
P
L
E
D
I
A
D
D
C
S
P
G
M
R
E
L
I
E
A
S
L
E
R
N
P
N
H
--
R
P
-----
R
A
------
A
-
D
L
L
K
H
E
A
L
N
-------------------------------------------------
48
HHSearch
37.50
17%
-71
- C1 -
-
4RA5
2
KPCT_HUMAN
A:
[121-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
------------
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
-
D
A
---------
K
T
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-
Q
-
K
----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
G
Q
D
E
E
E
---------------
L
-----------
F
H
S
I
----
R
-------
M
D
------------------------
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-----
G
V
------
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
---
L
E
R
K
E
------
I
D
P
P
F
R
P
K
V
--------------------
33
HHSearch
36.13
22%
-13
- C1 -
-
4GV1
4
AKT1_HUMAN
A:
[123-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
------------
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
----------
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-
N
-
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---------------
K
L
F
-----------
E
----
L
I
L
-------
M
E
------------------------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
GGGS
E
D
A
------
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
---
V
Y
E
K
K
------
L
S
P
P
F
K
P
Q
V
--------------------
22
Fugue
35.45
15%
13
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
LGRG
S
F
G
E
V
H
R
M
E
D
KQT
G
F
Q
C
A
V
K
K
V
R
L
E
-
V
F
R
A
E
E
L
M
A
C
A
G
L
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
G
C
L
P
-
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
DV
K
A
D
N
V
L
L
S
S
D
G
S
H
A
A
L
C
D
F
G
H
A
V
----
C
L
Q
I
P
G
-----
T
E
T
H
M
A
P
E
V
V
L
G
-
R
-
S
----
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
-----------------
C
H
P
W
T
Q
F
F
R
G
P
L
C
L
K
I
------
A
S
E
------------------------------------
P
P
P
V
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
--
R
V
-----
S
A
------
A
-
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
----------------------------
4
PsiBlast_PDB
35.06
62%
-151
* C3 *
-
5D9H
-
STK39_MOUSE
A:
[268-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
--
R
P
-----
T
A
------
A
-
E
L
L
K
C
K
F
F
--------------------------------------------------
31
HHSearch
34.42
14%
-79
- C1 -
-
4JRN
1
?
A:
[217-355]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
Q
A
-
Q
G
I
V
H
T
D
I
K
P
A
N
F
L
L
L
K
D
G
R
------------
L
F
L
G
D
F
G
T
Y
R
I
N
N
S
--------------
V
G
R
--
G
T
P
G
Y
E
P
P
E
R
P
-
G
-
I
-
T
----
Y
T
F
P
T
D
A
W
Q
L
G
I
T
L
Y
C
I
W
C
K
E
-
R
P
T
P
A
D
G
I
---------------------------------
W
D
Y
L
----------------------------------
H
F
A
D
C
P
S
T
P
E
L
V
Q
D
L
I
R
S
L
L
N
R
D
P
Q
K
--
R
M
-----
L
P
------
L
-
Q
A
L
E
T
A
A
F
K
E
M
D
S
V
--------------------------------------------
34
HHSearch
34.36
14%
-42
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[171-347]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
H
S
-
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-----------
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
-
E
----------
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
-
A
T
D
----
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
-
P
I
F
P
G
D
S
G
V
D
Q
----
L
-------
V
E
I
I
K
V
L
G
------
T
P
T
-----
R
E
Q
I
R
E
M
N
P
N
Y
T
---
E
----
F
K
F
P
Q
I
K
---
A
H
P
W
T
K
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
--
R
L
-----
T
P
------
L
-
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
-------------------------------------------
50
HHSearch
33.39
22%
-98
- C- -
-
4OTD
-
PKN1_HUMAN
A:
[736-887]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
G
------------
Y
V
K
I
A
D
F
G
L
C
K
E
G
M
G
Y
G
D
----------
R
T
S
T
F
C
G
T
P
E
F
L
A
P
E
V
L
T
D
-
T
-
S
----
Y
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
-
S
P
F
P
G
D
D
E
E
---------------
E
V
F
--------------
D
S
I
V
--------
N
D
------------------------
E
V
R
Y
P
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
GSSE
R
D
A
------
E
-
D
V
K
K
Q
P
F
F
R
T
L
G
W
E
A
-------------------------------------------
36
HHSearch
32.60
17%
-20
- C1 -
-
3RP9
-
?
A:
[171-407]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
H
S
-
A
G
I
L
H
R
D
L
K
P
A
N
C
L
V
N
Q
D
C
------------
S
V
K
V
C
D
F
G
L
A
R
T
V
D
Y
P
E
N
G
N
SQLP----------
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
-
N
----
Y
T
E
A
I
D
V
W
S
I
G
C
I
F
A
E
L
L
N
M
I
-
K
E
N
V
A
Y
H
A
D
R
G
PLFP---------------
T
R
G
N
R
D
Q
L
N
V
I
F
N
I
L
G
T
P
S
E
E
D
I
E
A
L
E
K
E
D
A
K
R
Y
I
R
I
F
P
K
R
----
E
G
T
D
L
A
E
R
F
P
A
S
S
A
D
A
I
H
L
L
K
R
M
L
V
F
N
P
N
K
--
R
I
-----
T
I
------
N
-
E
C
L
A
H
P
F
F
K
E
V
R
I
A
E
-------------------------------------------