@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_26_2110: (2018-03-10 )
MSNRSLHGGHTTIHNNNAYHDAAKEERQLQEQQKPSMPGSHAAVERMTAVQVVDRLRWWRTHRVREQPIPVDHFVLRGSYANYSSFGTRPLAPSVTRLLQKARTVRAQYLRTQQQPQHEAPRQSRQVSSLLMAPTAGASVRSASNERLGSDAGETERTTGCISEEEGQYGERQQRQLREMNDDAKEKVNNKRRAAVIASWPRSPRPLNEVAIACLGEPAGQRDSATDNITRISLSASGSAGTSPPLVRAVSGSAPSVDTPSGALYVPSEQEARVAERLLMLFRPRAASAPLRSRRYRCTAGRLDATSSEFSGEPPLQGDWGHAEATGLHHERMTRVSASDEITDVRRAPGAAEAVIVLHHAPRLVLYEKGLHPKAALRAAGISSDALESLDDAAAESSAELFALRNLPLFAFERFFYQQQLRGLAETRRSHTPGMRSASADASAESAGVPESDTASAPTGAAAGAVAAADTAVDDDIIANGDDAFFFGSPLTATLACSLKTVVPLSSVAAAAAPGSRGRDGRDAAARQAVQHRGRGRDDGSNRRRGGRAALRAVSVPALPPVYKGGCPQMTLATSHHHLSSGARLQQQQQSSNRPSPILSAGLRSSKAPQNGAHLCLRVDDLQDVYVFNPVVDMIGKGAFSKVYAAVPILRGKEGLRRFASPLLDGQAAPCGSDELSGSGPREGGRRVSTVRRVSPVRRNSSSTALRVDPAAGAAVGDAAGPLTDDETAKRRPHAQSLAASLHSIPVVALKVIPRKARQKPKAAPDPLATTHSTAAAAAGSVASNAQQAAQNDQNSVRRELVEIEREVSILRSLHHTGCSQFFEAIRTPDAFVIAMRVFPGSMDAQRYLSRYGAPSEARAALLLFQLVSTVQYLHTNFGLIHRDIKLENILLSEADAGVPDARIREVLGPALHKSDTSAMMTEIEGGRKGCASATTAAETRTAAQRRYSMLSRNVARLLRVTLIDFGLARRTRASTLSPIVAASRGRGAGAQHGSLNATITSPTHLASFPPTSASLAASHPHASHNPNSSSYSGSLGSPASSSAGCAAGVVMLANGGNSSSNSYTPAKPAPPKPPLLCRPPSAAVGAGTARLGSSSAGISAMERSTPRAGMPSPMPSTANMFTRFLDLEEEMDEEENGGAAGTSNTTANTTTKVGDLGRGGRRDMAENEDDSGAFSTDVSASETDCESEGGSTAEPKEGSAPNGEERLETGPQQEHVARKALISPSVLRAHPQTPPGSAIIVSPPLPPTPMLLSSTTAFTLDHFNAENSSSSCNTSGPAAGGAGLRNRCASCIYTSHQQLSPAPPVVAAGVSSAPDDTEATLLLTPCGTEKYLPPEVLSWILEHGWARRSTTVGLARAMDLYSIGIVAYVLLSGCFPFNASSRATLLQQQQRVPRCNSARWAGVSSAAISFVQRLLEPNPRKRMTAKEALEHPFLHEARQLAEKLSLVPHGEGEEASHPSTWRDGSHMDNHHRHSIGGTGRHFEDDANVHARSHWATSTTATTNLPHSAPSPTHPDHTHSGAAIERASTQPSSSVSLAVYDSQRRHAGGPCELAAANEPSPLSSNSGADGGGELLCHHVESGTAPTATSISSGCRLSDAPRVCRSSDECEKDDVRASVARDVPGKVQPLLQACKESPYSTTPPVPVTPTLAKPCTAALARAASIELPALSSLVAHPAKPSPSSTLYFTATGTTASADGGRAERATLPEPESAAAGSSAPALAPGSKDAAAANRPVSLSPAATTSTARATEGGEDDLFESLYNNIMSSD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.........710.......720.......730.......-740.......750.......760.......770.......780.....---------.------.790.......800.......810.......820.......830.......840.......850...--....860.......870.......880.......890..-----------------------------.------...-.900......-----.910...----....920.......930.......940.......950-----..-----------.......960.......970......----.980.......990.......1000......1010.......1020......1030--.......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130---........1140......1150......1160......1170......1180......1190-...-.....1200..-....1210......1220......1230......1240......--1250..--....1260......1270.....--..1280....---..1290......------1300....-------..1310......1320------..--------.....1330......1340......1350......1360......1370-......1380........1390.-...--..1400......1410......1420......1430..-....1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSNRSLHGGH
T
T
IHNNNAYH
D
A
A
K
E
E
R
Q
L
Q
E
Q
QKPSMPG
S
H
A
A
V
E
R
M
T
A
V
Q
V
V
D
R
L
R
W
W
R
THRVREQPIPV
D
H
F
V
L
RGSYANYSSFGTRPL
A
P
S
V
T
R
L
L
Q
K
A
R
T
V
R
A
Q
Y
L
R
TQQQPQHEA
P
R
Q
S
R
Q
V
S
S
L
LMAPTAGASVRSASNERLGSDAGETERTTGCISEEEGQY
G
E
R
Q
Q
R
Q
L
R
EMN
D
D
A
K
E
K
VNNKR
R
A
A
V
I
ASWPRSPR
P
L
N
E
V
A
I
ACLGEPAGQRDSATD
N
I
T
R
I
S
L
SASGSAGTSP
P
L
V
R
AVSGSAPSVDTPSG
A
L
YVP
S
E
Q
E
A
R
V
A
E
R
L
L
M
L
FRPRAASAP
L
R
S
R
R
Y
RCTAGRLDATSSEFSGEPPLQGDWGHAEATGL
H
H
E
R
M
TRVSASDE
I
T
D
V
RRAPGA
A
E
A
V
I
V
L
HHA
P
R
L
V
L
Y
EKGL
H
P
K
A
A
L
R
AAGI
S
S
D
A
L
E
S
L
D
D
A
A
A
ESS
A
E
L
F
A
LRNL
P
L
F
A
F
E
R
F
F
Y
Q
Q
Q
L
R
G
L
A
E
T
R
RSHTPGMRSASADASAESAGVPESDTASAPTGAAAGAVAAADTAVDDDIIANGDD
A
F
F
FGSP
L
T
A
T
L
A
CS
L
K
TVV
P
L
S
S
V
A
AAAAPGSRGRDG
R
D
A
A
A
R
Q
A
V
Q
HRGRGRDDGSNRRRG
G
R
A
A
L
RAVSVPALPPVYKGGCP
Q
M
T
L
A
TSHHHLSS
G
A
R
L
Q
Q
Q
Q
QSSNRPS
P
I
L
S
A
GLRSSKAPQNG
A
H
L
C
L
R
VDDLQ
D
V
Y
VFN
P
V
V
D
M
IGK
G
A
F
S
K
V
Y
A
AVPILR
G
K
E
G
L
R
R
F
A
S
P
LLDGQAAPCGSDELSGSGPREGGR
R
V
S
T
V
RRVSPVRRN--SSS
T
A
L
R
VDPAAGAAVGDAAGPLTD
D
E
T
AKRRP
H
A
Q
S
L
A
-
A
S
L
HSIP
V
V
A
L
K
VI
P
R
K
ARQKPKAAPDPLATTHS
T
A
A
AAAG
S
V
A
S
N
A
Q
---------
Q
------
A
A
QN
D
Q
N
S
V
R
R
E
L
V
E
I
E
R
E
V
S
I
L
R
S
L
H
H
T
G
C
S
Q
F
F
E
A
IRTP
D
A
F
V
I
A
M
RVFPGSM
D
A
Q
R
Y
L
S
RYGA
P
--
S
E
A
R
A
A
L
L
L
F
Q
L
V
S
T
V
Q
Y
L
H
TNF
G
L
I
H
R
D
I
K
L
E
N
I
L
LSE-----------------------------A------DAG-V
P
D
A
R
I
R
E
V
L
-----
G
P
ALHKS----
D
T
S
A
M
M
T
E
IEGGRKGCASAT
T
A
A
E
T
R
T
A
A
Q
R
R
Y
S
M
-------
L
S
-----------
R
N
V
A
R
L
L
R
V
T
L
I
D
FGLARRTRASTL
S
----
P
I
V
AASRGRGAGAQHGS
L
N
A
T
ITSPTHLASFP-PTSASLAASHPHASHNPNSSSY---SGSLGSPASSSAGC
A
A
G
V
V
M
L
ANGGNSSSNSYTPAKPAPPKPP
L
L
CRPPSAAVGAG
T
A
RLGSSSAGI
S
A
M
ERSTPRAGMPSPMP
S
T
A
N
M
F
T
R
F
L
D
L
E
E
E
-----MDEEENGGAAGTSNTTAN
T
T
T
KVGDLGRGGRRDMAENEDDSGAFSTDVSASETDCESEGG---STA-EPKEGSAPN
G
E
-
E
R
LETGP
Q
Q
E
H
V
A
R
K
ALI
S
P
S
V
L
RAHPQTPPG
S
A
I
I
VSPPLPPT--
P
M
L
LSS--T
T
A
F
T
L
D
HFNAENSS-SSCNTSG--PAAGG
A
G
L
R
N
---
R
C
A
S
C
I
YTSHQQ------LSPAP
P
V
V
-------AAGVSSAPDDT
E
A
T
L
-------
L
L--------TPCGTEKYL
P
P
E
V
L
S
W
I
L
EHGWARRSTT
V
G
L
A
R
A
M
D
L
Y
S
I
G
I
V
A
Y
V
L
L
S-GCFPFNA
S
--
S
R
A
T
L
L
Q
Q
Q
Q
RVP-RCN--SARWAG
V
S
S
A
A
I
S
F
V
Q
R
L
LEPNPRKR
M
T
A
K
E
A
LEH
P
F
L
-
H
E
A
R
Q
L
A
E
K
L
SLVPHGEGEEASHPSTWRDGSHMDNHHRHSIGGTGRHFEDDA
N
V
H
A
R
S
H
WATSTTATTNLPHSAPSPTHPDHTHSGA
A
I
ERASTQPSS
S
V
S
L
A
V
YDSQRRHAGGP
C
E
L
AAANEPSPLSSNSGADGGG
E
L
L
C
H
HVESGTAPTATSISSGCRLSDA
P
R
VCRSSDEC
E
K
D
D
V
R
A
S
V
A
RDVPG
K
V
Q
P
L
L
Q
A
C
KESPYSTTPPVPVTPTLA
K
P
C
T
A
A
L
A
R
A
ASIE
L
P
A
L
S
S
L
VAHPAKPSPS
S
T
L
Y
F
T
ATGTTASADGGRAERATLPEPESAAAGSSAPALAPGSKDAAAANR
P
V
SLSPAATTSTARATEGG
E
D
D
L
F
E
S
L
Y
N
N
I
MSSD
52
Fugue
63.46
17%
6
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
T
W
R
P
R
Y
F
L
L
K
N
D
--
G
T
F
I
G
Y
K
E
R
P
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
--
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
---------
I
------
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
---
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
-
E
L
F
F
H
L
S
R
E
R
V
F
--
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
-----------------------------
D
G
H
I
K
I
T
D
F
G
L
C
P
E
Y
L
A
P
E
V
L
E
DNDY
G
R
A
V
D
W
W
----
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
-------------------
P
F
-------
Y
N
-----------
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
----
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
---
T
D
T
R
Y
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
53.95
13%
37
- C1 -
-
3DZO
-
?
A:
[13-382]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
Y
F
Q
G
F
R
G
T
D
P
G
D
V
V
I
E
E
L
F
N
R
I
P
Q
A
NVRTT
S
E
Y
A
A
D
S
L
V
S
T
S
L
W
N
T
G
Q
P
F
R
V
E
S
E
L
G
E
R
P
R
T
L
V
R
G
T
V
L
G
Q
E
D
P
Y
A
Y
L
E
A
T
D
Q
E
T
G
E
S
F
E
---
V
H
V
P
Y
F
T
E
R
A
I
K
Q
M
K
-
E
E
V
L
R
L
R
L
L
R
G
I
K
N
Q
K
Q
A
K
V
H
L
------
R
F
I
F
P
F
D
L
V
K
D
P
Q
V
L
S
--
R
F
F
L
Y
P
--
R
M
Q
S
N
L
Q
T
F
G
E
V
L
L
S
H
S
S
T
H
K
S
L
--
V
H
H
A
R
L
Q
L
T
L
---
Q
V
I
R
L
L
A
S
L
H
H
Y
GLVHTY
L
R
P
V
D
I
V
L
D
QRG
G
V
F
L
T
G
F
E
H
L
V
R
D
G
A
S
A
V
-----------------
S
P
I
G
R
-
G
F
A
P
P
E
T
T
A
E
R
M
L
P
F
G
Q
H
H
P
T
L
M
T
--
F
A
F
D
T
W
T
L
G
L
A
I
Y
W
I
W
C
-
A
D
L
P
N
T
D
D
--
A
A
L
G
G
S
E
W
I
F
R
S
C
-
K
---------
N
I
P
Q
P
V
R
A
L
L
E
G
F
L
R
Y
P
K
E
D
R
L
L
P
L
Q
A
M
E
T
P
E
Y
-
E
Q
L
R
T
E
L
S
A
A
L
P
L
Y
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
53.59
14%
14
- C1 -
-
2RIO
1
IRE1_YEAST
A:
[8-434]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
E
Q
S
L
K
N
L
V
V
S
E
K
I
L
G
Y
G
S
S
G
---
T
V
V
-
F
Q
G
S
----
F
Q
G
-
R
P
V
A
V
K
R
M
L
I
D
F
C
D
I
A
L
M
E
I
K
L
L
T
E
S
D
D
H
P
N
V
I
R
Y
Y
C
S
E
T
T
D
R
F
--
L
Y
I
A
L
E
--
L
C
N
L
N
L
Q
D
L
V
E
S
K
Y
N
-
P
I
S
L
L
R
Q
--
I
A
S
G
V
A
H
L
H
S
---
L
-----
K
I
I
H
R
D
------
L
K
P
Q
N
I
L
V
S
TS----
S
R
F
T
A
D
Q
Q
T
G
A
E
N
L
R
-------
I
L
I
S
DFGL
C
K
K
L
D
S
T
S
G
W
R
A
P
E
L
L
-----
E
E
S
N
N
L
Q
T
K
R
R
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
S
K
G
K
H
P
F
G
D
K
YS
R
E
S
N
I
I
R
G
I
F
S
L
D
-
E
M
K
--
C
L
H
D
R
S
L
I
A
E
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
P
S
-----
A
L
L
M
K
F
D
A
G
S
D
F
V
I
P
S
G
D
W
T
V
K
F
D
K
T
F
M
D
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
N
L
S
D
D
Q
I
L
R
E
F
L
Y
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
53.13
16%
26
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
---
K
K
T
-
Y
M
A
K
F
V
K
V
K
G
T
-
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
--
A
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
E
L
V
M
I
F
E
F
I
S
G
--
L
D
I
F
E
R
I
N
T
S
A
F
E
L
N
E
R
E
I
V
S
Y
V
-
H
Q
V
C
E
A
L
--
Q
F
L
H
S
H
N
I
G
H
FDI
R
P
E
N
I
I
Y
Q
T
R
R
S
----------
S
T
I
K
-------
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
N
-------
F
R
--------
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
----------
Q
H
D
V
V
S
--
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
L
A
E
--
T
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
T
F
D
--
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
-
K
Q
K
I
E
R
V
S
T
---------
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
52.66
14%
22
- C1 -
-
1KOB
1
?
A:
[23-374]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
-
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
---------
K
ATG
R
V
F
V
A
K
F
I
N
T
P
Y
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
Y
K
M
--
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
-
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
KKASSVKIIDFGLATKLNPD
E
I
V
K
V
T
TAT
A
------
E
F
A
-
A
P
E
I
V
D
R
E
P
V
-----
G
F
Y
T
D
M
W
----
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
W
E
F
DEDAFSS
V
S
-----------
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
HPWL
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
-
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
52.27
16%
41
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
-----
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
Y
R
E
E
VH
W
A
T
H
-
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
R
A
E
E
L
M
A
C
A
G
---
L
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
--
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
-
Q
L
V
K
E
Q
G
CL
P
E
D
R
A
L
Y
Y
L
G
---
Q
A
L
E
G
L
E
Y
L
H
S
R
------
R
I
L
H
G
D
V
K
-------
A
D
N
V
L
L
S
S
D
G
S
H
A
A
L
C
DFGH
A
V
C
L
--------
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
------------
L
G
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
Q
F
--
F
R
G
P
L
C
L
K
I
A
S
E
P
-
P
P
V
--
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
-
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
48.76
11%
34
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
---------------
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
LI
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
-
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
RATG
K
M
Y
A
C
K
------
K
L
E
K
K
R
I
K
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
-
D
L
K
F
H
I
Y
H
M
G
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
-----------------------------
H
G-----
H
I
R
-
I
S
D
L
G
L
A
V
H
V
-----
P
E
G
Q
T
I
K
G
RVG
T
V
G
Y
M
A
P
E
V
V
K
N
E
----
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
-------
I
A
GQSPFQQR
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
----
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
G
S
A
R
E
V
K
E
H
P
L
F
K
-
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
---
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
48.48
33%
-20
- C1 -
-
4A9T
-
CHK2_HUMAN
A:
[175-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
L
-------
M
R
--------
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
---------
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
-
G
Y
P
P
F
S
E
H
--
R
T
Q
V
S
L
K
D
Q
I
T
S
G
-
K
Y
N
FI
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
-
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
48.08
33%
-22
- C1 -
-
2W7X
2
CHK2_HUMAN
A:
[169-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
L
-------
M
R
--------
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
---------
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
-
G
Y
P
P
F
S
E
H
--
R
T
Q
V
S
L
K
D
Q
I
T
S
G
-
K
Y
N
FI
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
-
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
47.37
33%
-23
- C1 -
-
2YCF
-
CHK2_HUMAN
A:
[169-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
L
-------
M
R
--------
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
---------
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
-
G
Y
P
P
F
S
E
H
--
R
T
Q
V
S
L
K
D
Q
I
T
S
G
-
K
Y
N
FI
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
-
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
47.32
33%
-17
- C1 -
-
2YIR
-
CHK2_HUMAN
A:
[169-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
L
-------
M
R
--------
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
---------
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
-
G
Y
P
P
F
S
E
H
--
R
T
Q
V
S
L
K
D
Q
I
T
S
G
-
K
Y
N
FI
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
-
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
47.18
33%
-22
- C1 -
-
2YCQ
-
CHK2_HUMAN
A:
[169-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
L
-------
M
R
--------
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
---------
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
-
G
Y
P
P
F
S
E
H
--
R
T
Q
V
S
L
K
D
Q
I
T
S
G
-
K
Y
N
FI
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
-
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
46.95
33%
-16
- C1 -
-
2XM9
-
CHK2_HUMAN
A:
[175-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
L
-------
M
R
--------
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
---------
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
-
G
Y
P
P
F
S
E
H
--
R
T
Q
V
S
L
K
D
Q
I
T
S
G
-
K
Y
N
FI
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
-
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
46.48
33%
-14
- C1 -
-
2YIT
-
CHK2_HUMAN
A:
[169-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
L
-------
M
R
--------
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
---------
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
-
G
Y
P
P
F
S
E
H
--
R
T
Q
V
S
L
K
D
Q
I
T
S
G
-
K
Y
N
FI
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
-
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
46.26
33%
-11
- C1 -
-
2WTI
-
CHK2_HUMAN
A:
[175-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
L
-------
M
R
--------
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
---------
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
-
G
Y
P
P
F
S
E
H
--
R
T
Q
V
S
L
K
D
Q
I
T
S
G
-
K
Y
N
FI
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
-
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
46.11
33%
-18
- C1 -
-
4BDB
5
CHK2_HUMAN
A:
[175-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
L
-------
M
R
--------
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
---------
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
-
G
Y
P
P
F
S
E
H
--
R
T
Q
V
S
L
K
D
Q
I
T
S
G
-
K
Y
N
FI
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
-
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
45.85
33%
-18
- C1 -
-
4BDF
1
CHK2_HUMAN
A:
[175-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
L
-------
M
R
--------
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
---------
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
-
G
Y
P
P
F
S
E
H
--
R
T
Q
V
S
L
K
D
Q
I
T
S
G
-
K
Y
N
FI
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
-
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
45.62
33%
-19
- C1 -
-
4BDA
3
CHK2_HUMAN
A:
[175-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
L
-------
M
R
--------
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
---------
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
-
G
Y
P
P
F
S
E
H
--
R
T
Q
V
S
L
K
D
Q
I
T
S
G
-
K
Y
N
FI
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
-
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
45.53
33%
-21
- C1 -
-
4BDC
-
CHK2_HUMAN
A:
[175-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
L
-------
M
R
--------
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
---------
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
-
G
Y
P
P
F
S
E
H
--
R
T
Q
V
S
L
K
D
Q
I
T
S
G
-
K
Y
N
FI
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
-
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
45.34
33%
-18
- C1 -
-
2YIQ
-
CHK2_HUMAN
A:
[169-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
L
-------
M
R
--------
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
---------
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
-
G
Y
P
P
F
S
E
H
--
R
T
Q
V
S
L
K
D
Q
I
T
S
G
-
K
Y
N
FI
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
-
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------