@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_26_2540: (2018-03-10 )
MSTGDLLTPGALWQDDANVFVCSGRRCGRRFNRLFCPKHHCRWCGRVYCDACAPKQTIYKRQLLRKCNRCRLPAVFRHSWNARTRGMDCTPFECIISYLTPRSITALLQSCHTMMSEFPVCGYPFYDSIQQRFPSFYPGAQIGRGTFGTVFKCEDRSAADHKRAILKCISKATNLTYTRWMGALTELRILESVNHPNVAHLLGAFQTREDLVIVMEAGEGGTARRAAACVREYGQAAEEAFTANIIEGVASGLDYLYREKHIIHRDIKLDNIVLSADYSTPMIIDFGLAEFVVNEEEQWYVVGGTRNYAAPESIAAVANGHVDMREPGITMHKGDLFSLGVVAYYLLSGHRPFRSRSFDKMHEEMRRGVACTGPLWDGVSSDARELVQALLSYDPAQRPDYAAIKENPFIMARAAGVKSIQMQRNARLLLDEEETHAEWVTLEPSDLREAVDEGESEVLLPLSTPQRWYHAYLPRFSLLHL
Atome Classification :
(20 SA)
---.........10........-------20........30......-----..40........50..--......60........70.......-.80........90........100.......110..---.....120.......130.......140-.......150.......160.......170...-----....180.......190.-......200.......210.......220.......230.......240.......250.......260.......270..--..-..--.280....-.....-290......-..300.......310.......320.......330.......340......-.350..-...-..360.-----.......-.-370.-......380.......390.....--..-----400----........410.......420.......430.......440.......450.......460.......470.......480----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---MSTGDLLTPGALWQDDA
N
V
-------
F
V
CSG
R
R
C
G
R
R
F
N
RLFC
P
-----
K
H
H
C
R
W
C
G
R
V
Y
CDACA--
P
K
Q
T
I
Y
K
R
Q
L
L
R
K
CNRCRL
P
A
V
F
RH-SWNARTRGMDC
T
P
F
E
C
I
I
S
YL
T
P
R
S
I
T
A
L
L
Q
S
C
H
T
M
---
M
S
EFPVCGY
P
F
Y
D
S
I
Q
Q
RFPSFYPGAQI-GRGTFG
T
V
F
K
CEDRSA
A
D
H
K
R
A
I
L
K
C
I
S
K
ATNL-----
T
Y
T
R
W
M
G
A
L
T
E
L
R
I
L
E
SV-NHP
N
V
A
H
L
L
G
A
FQTRE
D
L
V
I
V
M
EAGEGG
T
A
R
R
A
A
A
C
V
R
E
Y
G
Q
A
A
E
E
A
F
T
A
N
I
I
E
G
V
A
S
G
L
D
Y
L
Y
R
E
K
H
I
I
H
RD
I
K
L
D
N
I
V
L
--SA-DY--ST--
P
M
I
I
-DF
G
L
A
-
E
-
F
V
VNEEE-
Q
W
Y
V
VGGTRNYAA
P
E
S
I
A
A
V
ANGH
V
D
MREPGITMHKG
D
L
F
S
L
G
V
V
A
Y
Y
L
LS-GHRPFR-SR
S
-
F
D
K
--
M
-----
H
E
E
M
R
RG-V-ACTG-PLWDG
V
S
S
D
A
R
E
L
V
Q
A
L
LSYDPAQ--RP-----D
Y
-----
A
AIKEN
P
F
I
M
A
RAAG
V
K
S
I
Q
MQRN
A
R
L
L
LDEEETHA
E
W
V
TL
E
P
S
D
L
R
E
A
V
DEGES
E
V
L
L
PLST
P
Q
R
W
Y
H
A
YLP
R
F
SLLHL-----
36
HHSearch
70.89
29%
-95
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[9-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
-
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
--
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-----
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
---
E
-
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
--
D
K
-
D
---
G
H
--
I
K
I
T
-
D
F
G
L
C
-
K
-
E
G
I
K
D
G
A
-
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----------
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
-
G
R
L
P
F
Y
-
N
Q
D
-
H
E
K
--
L
-----
F
E
L
I
L
M
E
-
E
-
I
----
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
GGGS
E
D
A
-----
K
E
I
M
Q
H
R
F
F
A
G
I
V
------------------------------------------------------------------------
24
HHSearch
66.20
26%
-111
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[95-351]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
N
F
I
K
I
-
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
--
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
--------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
-----
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
--
T
H
-
D
---
G
R
--
V
K
L
S
-
D
F
G
F
C
-
A
-
Q
V
S
K
E
V
P
-
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
-----------
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
-
G
E
P
P
Y
F
-
N
E
P
-
P
L
K
--
A
-----
M
K
M
I
R
D
N
-
L
-
P
P
R
L
-
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
A
-----
T
A
-----
A
E
L
L
K
H
P
F
L
A
K
A
G
------------------------------------------------------------------------
50
Fugue
64.40
22%
-26
- C1 -
-
3CD3
3
A:
[1-376]
--------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
-------
W
---------------------------
Y
H
G
A
I
P
R
A
E
V
A
--
E
L
L
V
H
S
G
D
F
L
V
R
E
----------------
S
Q
E
Y
V
L
S
V
P
R
H
F
I
I
N
L
Y
R
L
F
P
S
I
P
L
L
I
D
H
L
L
S
T
QQP
L
S
G
V
V
L
H
R
A
V
P
K
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
-
G
R
G
N
F
G
E
V
F
S
G
R
L
R
--
A
D
N
T
L
V
A
V
K
S
C
R
P
D
L
K
A
-----
K
F
------
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
---
F
L
T
F
L
R
T
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
-
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
--
T
--
E
K
--
N
V
--
L
K
I
S
-
D
F
G
M
S
-
R
-
E
E
A
D
G
V
Y
---
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
-------
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
-
N
L
S
-
N
Q
Q
--
T
-----
R
E
F
V
E
K
G
-
G
-
R
L
P
C
-
P
--
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
--
R
P
-----
S
F
-----
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-----------------------------------------------------------------------
3
PsiBlast_PDB
63.74
31%
-82
- C1 -
-
5JZN
1
DCLK1_HUMAN
A:
[10-278]
----------------------------------------------------------------------------------------------------------------------------------------------
G
F
Q
I
P
A
T
I
T
E
R
Y
K
V
---
G
R
T
I
-
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
--
R
E
Y
A
L
K
I
I
K
K
S
K
C
R
-----
G
K
E
H
M
I
Q
--
N
E
V
S
I
L
R
R
V
-
K
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
N
K
Y
T
E
R
D
A
S
G
M
L
Y
N
L
----
A
S
A
I
K
Y
L
H
-
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
-
D
G
--
S
K
--
S
L
K
L
G
D
F
G
L
A
-
T
-
I
V
---
D
G
-
P
L
Y
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
A
E
T
G
Y
G
-----------
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
-
G
F
P
P
F
R
-
G
S
---
D
Q
E
V
L
-----
F
D
Q
I
L
M
G
Q
V
-
D
F
P
S
-
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
--
R
F
-----
S
A
-----
V
Q
V
L
E
H
P
W
V
----------------------------------------------------------------------------
47
Fugue
63.01
20%
10
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
RD
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
LDLGFE
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
EQH
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
DD
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
---
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
P
M
G
E
D
W
F
L
D
F
R
V
L
-
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
--
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
-----
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
-
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
--
D
--
D
D
--
G
N
--
V
R
I
S
-
D
L
G
L
A
-
V
-
E
L
K
A
G
Q
T
-
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
G
E
E
Y
D
F
-----------
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
-
A
R
G
P
F
R
-
A
R
G
-
E
K
V
--
E
-----
N
K
E
L
K
Q
R
-
V
-
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
--
R
L
-----
G
F
RDGSC
D
G
L
R
T
H
P
L
F
--
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
G
A
F
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
VWRP
2
PsiBlast_PDB
62.34
31%
-87
- C1 -
-
5JZJ
2
DCLK1_HUMAN
A:
[27-295]
----------------------------------------------------------------------------------------------------------------------------------------------
G
F
Q
I
P
A
T
I
T
E
R
Y
K
V
---
G
R
T
I
-
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
--
R
E
Y
A
L
K
I
I
K
K
S
K
C
R
-----
G
K
E
H
M
I
Q
--
N
E
V
S
I
L
R
R
V
-
K
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
N
K
Y
T
E
R
D
A
S
G
M
L
Y
N
L
----
A
S
A
I
K
Y
L
H
S
-
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
-
D
G
--
S
K
--
S
L
K
L
G
D
F
G
L
A
-
T
-
I
V
---
D
G
-
P
L
Y
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
A
E
T
G
Y
G
-----------
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
-
G
F
P
P
F
R
-
G
S
-----E
V
L
-----
F
D
Q
I
L
M
G
Q
V
-
D
F
P
S
-
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
--
R
F
-----
S
A
-----
V
Q
V
L
E
H
P
W
V
----------------------------------------------------------------------------
27
HHSearch
61.89
26%
-75
- C1 -
-
4WOT
1
ROCK2_HUMAN
B:
[69-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
D
V
V
K
V
I
-
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
--
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-----
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
---
Y
--
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
--
D
K
-
H
---
G
H
--
L
K
L
A
-
D
F
G
T
C
-
M
-
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
-------
D
G
F
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
-
G
D
T
P
F
Y
-
A
D
S
-
L
V
G
--
T
-----
Y
S
K
I
M
D
H
-
K
N
S
L
C
F
-
P
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
-----
G
V
-----
E
E
I
R
Q
H
P
F
F
K
N
D
Q
------------------------------------------------------------------------
6
PsiBlast_PDB
61.26
30%
-70
- C1 -
-
3DFA
-
?
A:
[13-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
--
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
-----
N
-
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
-
E
L
F
D
E
I
I
K
R
K
R
F
S
----
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---------
K
D
C
D
I
K
I
I
-
D
F
G
L
S
-
T
C
F
Q
Q
N
T
K
M
-
K
D
R
I
--
G
T
A
Y
Y
I
A
P
E
----
V
L
R
G
T
Y
D
--------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
-
G
T
P
P
F
Y
-
G
K
N
E
Y
D
I
--
L
-----
K
R
V
E
T
G
K
-
Y
-
A
F
D
L
-
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
--
R
I
-----
T
A
-----
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
------------------------------------------------------------------------
35
HHSearch
60.68
26%
-76
- C1 -
-
3V8S
1
ROCK1_HUMAN
D:
[68-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
D
Y
E
V
V
K
V
I
-
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
--
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-----
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-----
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
--
D
K
-
S
---
G
H
--
L
K
L
A
-
D
F
G
T
C
-
M
-
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
-------
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
-
G
D
T
P
F
Y
-
A
D
S
-
L
V
G
--
T
-----
Y
S
K
I
M
N
H
-
K
N
S
L
T
F
-
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
-----
G
V
-----
E
E
I
K
R
H
L
F
F
K
N
D
Q
------------------------------------------------------------------------
32
HHSearch
60.38
25%
-22
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[93-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
K
Y
D
P
K
D
V
I
-
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
--
T
G
H
E
F
A
V
K
I
M
E
V
---
R
LSPEQ
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
---
K
-
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D
-
N
---
M
Q
--
I
R
L
S
-
D
F
G
F
S
-
C
-
H
L
E
P
G
E
--
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
-----
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
-
H
R
R
-
Q
I
L
--
M
-----
L
R
M
I
M
E
G
-
Q
Y
Q
F
S
S
-
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
L
-----
T
A
-----
E
Q
A
L
Q
H
P
F
F
E
---------------------------------------------------------------------------
34
HHSearch
60.05
25%
-150
- C1 -
-
4JXF
2
PLK4_HUMAN
A:
[5-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
E
D
F
K
V
G
N
L
L
-
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
--
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
-----
K
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
-
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
---
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
--
T
R
-
N
---
M
N
--
I
K
I
A
-
D
F
G
L
A
-
T
-
Q
L
K
M
P
H
E
-------------------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
-
G
R
P
P
F
------
V
K
N
--
T
-----
L
N
K
V
V
L
A
-----
D
Y
-
E
M
P
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
--
R
L
-----
S
L
-----
S
S
V
L
D
H
P
F
M
S
R
--------------------------------------------------------------------------
12
PsiBlast_PDB
59.72
30%
-60
- C1 -
-
4Y5Q
1
?
A:
[30-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
--
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
-----
N
-
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
----
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
E
S
-
K
E
--
K
D
C
D
I
K
I
I
-
D
F
G
L
S
-
T
C
F
Q
Q
N
T
----
D
R
I
--
G
T
A
Y
Y
I
A
P
E
----
V
L
R
G
T
Y
D
--------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
-
G
T
P
P
F
Y
-
G
K
N
E
Y
D
I
--
L
-----
K
R
V
E
T
G
K
-
Y
-
A
F
D
L
-
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
--
R
I
-----
T
A
-----
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
I
------------------------------------------------------------------
11
PsiBlast_PDB
59.35
30%
-66
- C1 -
-
3NCG
1
?
A:
[30-327]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
--
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
-----
N
-
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
----
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
E
S
-
K
E
--
K
D
C
D
I
K
I
I
-
D
F
G
L
S
-
T
C
F
Q
Q
N
T
------
I
--
G
T
A
Y
Y
I
A
P
E
----
V
L
R
G
T
Y
D
--------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
-
G
T
P
P
F
Y
-
G
K
N
E
Y
D
I
--
L
-----
K
R
V
E
T
G
K
-
Y
-
A
F
D
L
-
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
--
R
I
-----
T
A
-----
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
I
------------------------------------------------------------------
30
HHSearch
59.24
25%
-18
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[93-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
K
Y
D
P
K
D
V
I
-
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
--
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
LSPEQ
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
---
K
-
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D
-
N
---
M
Q
--
I
R
L
S
-
D
F
G
F
S
-
C
-
H
L
E
P
G
E
--
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
-----
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
-
H
R
R
-
Q
I
L
--
M
-----
L
R
M
I
M
E
G
-
Q
Y
Q
F
S
S
-
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
L
-----
T
A
-----
E
Q
A
L
Q
H
P
F
F
E
---------------------------------------------------------------------------
29
HHSearch
58.67
25%
-66
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[90-350]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
S
K
T
E
I
L
-
G
-----
Q
V
H
K
C
E
E
T
A
--
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
K
--------
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
---
E
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
-
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
--
V
N
R
D
A
--
K
Q
--
I
K
I
I
-
D
F
G
L
A
-
R
-
R
Y
K
P
R
E
--
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
-----------
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
-
G
L
S
P
F
L
-
G
D
N
-
D
A
E
--
T
-----
L
N
N
I
L
A
C
-
R
W
D
L
E
D
-
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
--
R
I
-----
S
A
-----
S
E
A
L
K
H
P
W
L
S
D
H
K
------------------------------------------------------------------------
9
PsiBlast_PDB
58.41
30%
-62
- C1 -
-
3IGO
8
?
A:
[30-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
--
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
-----
N
-
K
-
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
----
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
E
S
-
K
E
--
K
D
C
D
I
K
I
I
-
D
F
G
L
S
-
T
C
F
Q
Q
N
T
----------
T
A
Y
Y
I
A
P
E
----
V
L
R
G
T
Y
D
--------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
-
G
T
P
P
F
Y
-
G
K
N
E
Y
D
I
--
L
-----
K
R
V
E
T
G
K
-
Y
-
A
F
D
L
-
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
--
R
I
-----
T
A
-----
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
I
------------------------------------------------------------------
7
PsiBlast_PDB
58.22
30%
-61
- C1 -
-
2WEI
1
?
A:
[30-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
--
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
-----
N
-
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
----
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
E
S
-
K
E
--
K
D
C
D
I
K
I
I
-
D
F
G
L
S
-
T
C
F
Q
Q
N
T
K
M
-
K
D
R
I
--
G
T
A
Y
Y
I
A
P
E
----
V
L
R
G
T
Y
D
--------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
-
G
T
P
P
F
Y
-
G
K
N
E
Y
D
I
--
L
-----
K
R
V
E
T
G
K
-
Y
-
A
F
D
L
-
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
--
R
I
-----
T
A
-----
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
-----------------------------------------------------------------------
1
PsiBlast_PDB
58.12
30%
-74
- C1 -
-
3IS5
3
?
A:
[29-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
-
G
S
G
A
F
G
D
V
H
L
V
E
E
R
S
S
G
L
E
R
--
V
I
K
T
I
N
K
D
R
S
Q
-----
V
P
M
E
Q
I
E
A
--
E
I
E
V
L
K
S
L
-
D
H
P
N
I
I
K
I
F
E
V
F
E
D
Y
H
N
M
Y
I
V
M
E
T
C
E
G
G
E
L
L
E
R
I
V
S
A
Q
A
R
G
K
A
L
S
E
G
Y
V
A
E
L
M
K
Q
M
M
N
A
L
A
Y
-
F
H
S
Q
H
V
V
H
K
D
L
K
P
E
N
I
L
F
QD
T
S
-
P
H
--
S
P
--
I
K
I
I
-
D
F
G
L
A
-
E
-
L
------------
A
G
T
A
L
Y
M
A
P
E
---------
V
F
K
R
D
---
V
T
F
K
C
D
I
W
S
A
G
V
V
M
Y
F
L
L
T
-
G
C
L
P
F
T
-
G
T
S
-
L
E
E
--
V
Q
Q
K
A
T
Y
K
E
P
N
Y
A
-
V
---
R
--
P
L
----
T
P
Q
A
V
D
L
L
K
Q
M
L
T
K
D
P
E
R
--
R
P
-----
S
A
-----
A
Q
V
----------------------------------------------------------------------------------
10
PsiBlast_PDB
58.09
30%
-62
- C1 -
-
3MWU
1
?
A:
[30-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
--
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
-----
N
-
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
----
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
E
S
-
K
E
--
K
D
C
D
I
K
I
I
-
D
F
G
L
S
-
T
C
F
Q
Q
N
-----
D
R
I
--
G
T
A
Y
Y
I
A
P
E
----
V
L
R
G
T
Y
D
--------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
-
G
T
P
P
F
Y
-
G
K
N
E
Y
D
I
--
L
-----
K
R
V
E
T
G
K
-
Y
-
A
F
D
L
-
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
--
R
I
-----
T
A
-----
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
I
------------------------------------------------------------------
8
PsiBlast_PDB
57.92
30%
-24
- C1 -
-
3MA6
1
?
A:
[30-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
--
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
-----
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
----
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
-
K
S
KD
A
N
--
I
R
I
I
-
D
F
G
L
S
T
H
-
F
E
-
S
K
K
M
-
K
D
K
I
--
G
T
A
Y
Y
I
A
P
E
----
V
L
H
G
T
Y
D
--------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
G
A
N
E
-
Y
D
I
--
L
-----
K
K
V
E
K
G
K
-
Y
-
T
F
E
L
-
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
--------------------------------------------------------------------------------------------------