@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_27_1290: (2018-03-10 )
MSSSPSDTHSSAFPDATSVAAAFSRDDFFECPRCHRHCKSRTWFLKHLEACSKSASSSSTHGNTVSGEGSGGSPRTAAFATKVKNHHRHPSRSSATEDVTPLLLESATSTTSSSSATSYSHVHSHKPSGLTHPTGSSGREVAPSHLIEAGLSADTGLSRSSAVGFGGYRDGRRESNNTTPTATSQASPHWPIDDLPIASSASGVGTGAGGSIVANGMSRPTSPSQGSSLYAGSPRGLRAGESCGESGSAHASTAFGRTSAPAAAAASSSFSTAQRDEAEQHRQPARQDSFRLQSDFTWTQYTPSASEEDGDDEALGEHDGSILDHSSRQLLRSLGRVQRGNNPAPREAGTSLCSIGADRLMAPGDADKTPDRWAYEQQLSGKSSHHRSTPPSAAGDVGRHTATGMLQGASFPLEGEQQMQRRFSASISEFSPTECNVIGAADGSQSVGSASNSDRFHRSARDSASPVSPICMSSASPMFVQATGSPSLLHINVSPTSTTAAGSSMSRLNGMNASSSGGGGRTPRHGDRSGAVTPRAISFQRGRAVGSGGFGIVYQAILSDGSLAAVKELKLENANLKAIDREVRAMSSIPPHPNCVRYLGSRYSAHHYYIIMEYISGGSINSLRKSVGRFRESVFQRYAYMVLLGLSHLHANGILHRDIKGANVLLDESGCAKIVDFGCSGNLNQATTTLSGGGTPLWMAPEVCRGEPATEKSDVWAFGCLCLEMTNDTGMPWNFPPGMTLQGVVYALACAKSPPAIPTDLSLEAQDFLRRCLRIDPGERATVAELLQHPFFDVDLMEDSEEDELLSSYGASARQSAVKRAVRQVNLSSALDAAAHQQERQQYRGEGDEVGGGAKDMQVSSPVQVFAGMSLPSQGMHSSGHRPISDPDAGALLRSPNSHSKSASGPQLDHYTRSVNIGFSLQAVDEDDDDDGGGAEKAEDNVGPSHNLLGGSPPAIPETAASTDRCRTTSFKSAGVEEDENEYTQMITEIITQAREAYTDEERRLTERRRRLNMMHRSSDEDTSLTATMSSGSDTSNNGGSAGSAGCSFAEEGERSEHVDIESDLSTLSGSDGDVGARSRSVGGPRRHSLGTTWRDQSARASAATENSEELLQNTDREVPHHEPACAARVKDPTAPSASALSACRSRFPGSDARASTTLAATSPTSAHVGSWDTSISLYATSPSSSTRGLEAGPQFQRSPHGLVLPLPLASSYPRQQQQQQQQQQQRPCPVSPPTRQREVMRRELPRDKSRSRGGASFGKSPYDGVVAKAAGGVARAPREPGGPVGVATTIRQPAGSSPLSPHTSASAETPPPLSSSPATQSSTICGAVLSERSSSSRTPPLTVGGPHRQTPPQPLATTTATSSAHSDIVACPIEWYTGGSGRLDVSSATWRTGASGHLPKELSMAQKEMQEMLDWGTSSDRHHALSSSSPDIGRRSSKALPTATNSAVRGGEGHHNHHRLHHLCHNHGDDLDSECTAEAESLSHHESRGLSATETVAAAQQPAKRKLWGLGIFRNLRSK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530......------------.540.......550.....-.-.-560.-.....--..---570...-.-.-....580.......590.......600----.........610.......620.-.....-.---630-........640.......650.......660....---..-.670........680......-..690.---......700..---.---..-----..-710.-----......720.......730.......740..-.....750-.---.---.----------..---..760-........770-....--....780---.........790---.......800----........810.......820......-----.830.......840.......850.......860.......870.......880.......890.......900.......910.......920........930.......940.......950.......960.......970.......980.......990.......1000........1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSSSPSDTHSSAFP
D
A
T
S
V
A
A
AFSR
D
D
F
F
E
C
P
R
C
H
R
H
C
KS
R
T
W
F
L
K
H
L
E
A
C
S
KSASSSSTHGNTVSGEGSGGSPR
T
A
A
F
A
T
K
V
K
NHHRHPSRSSATE
D
V
T
P
L
L
L
ESATSTTSSSSATSYSHVHSHKPSGLTHPTGSSGREV
A
P
S
H
L
I
E
AGLSADTGLSRSSAVGFGGYRDGRRESNNTTPTATSQASPHWPIDDLPIASSASGVGTGAG
G
S
I
V
ANGMSRPTSPSQGSSLYAGSPRGLRAGESCGESGSAHASTAFGRTSAPAAAAASSSFSTA
Q
R
D
E
A
E
Q
H
RQPARQD
S
F
R
LQSD
F
T
W
T
QYTPSASEEDGDD
E
A
LGEHDGSIL
D
H
S
S
R
Q
L
L
R
S
L
G
R
V
QRGNNPA
P
R
E
AGT
S
L
C
SIGADRLMAPGDADKTP
D
R
W
A
Y
E
Q
QLSGKSSHHRSTPPSAAGDVG
R
H
T
ATGMLQGASFPLE
G
E
Q
Q
M
Q
R
R
F
S
A
S
ISEFSPTE
C
N
V
I
GAADGSQSVGSASN
S
D
R
F
H
RSARDSASPVS
P
I
CMSSAS
P
M
F
V
Q
ATGSP
S
L
L
H
I
NVSPTSTTAAGS
S
M
S
R
LNGMNASSSGGGGRTPRHGDRSGAVTP
R
A
I
S
------------FQRGRAVGSG
G
F
G
I
V
Y
Q
A
I
-L-S-D-G
S
-
L
A
A
V
K
--
E
L
---K--LEN-A-
N
-
L
K
A
I
D
R
E
V
R
A
M
SSIPPH
P
N
C
V
R
Y
L
G
------SRYSA
H
H
Y
Y
I
I
M
E
YISGG
S
I
N
S
L
-
R
K
S
V
G
-
R
---
F
R
--
E
S
V
F
Q
R
Y
A
Y
M
V
L
L
G
L
S
H
LHANG
I
L
HRDIKG
A
N
V
L
L---DE-SGC-
A
K
I
VDFGCSG-NLN
Q
A
T
-
T
TLSGG---G
T
P
L
WMA
P
E
VC---R---GE-----PA-TEKS-----D
V
W
A
F
G
C
L
C
L
E
MTNDTGMPWNFPPG
M
T
L
Q
G
V
-
V
Y
A
L
A
CAK-S---P---P----------AI---PTDL--SL
E
A
Q
D
F
L
R
R
--
C
LRI--DPGER-----
A
T
V
A
E
L
L
QHPFF---
D
V
DLMEDS
E
-----
E
D
E
L
L
S
SYG
A
S
A
R
Q
S
A
V
K
R
A
V
R
QV
N
L
S
-----
S
A
L
D
A
A
A
H
Q
Q
E
R
Q
Q
YRGEGDEVGGGAKDMQVSS
P
V
Q
V
F
AGMSLPSQGMHSSGHRPISDPDA
G
A
LLRSPNSHSKSASGPQLD
H
Y
T
R
S
V
NI
G
F
S
L
-
Q
AVDEDDDDDGGGAEKAEDNVGPSHNLLGGSPPAIPETAASTDRCRTTSFKSAGVEE
D
E
N
E
Y
T
Q
M
I
T
E
I
I
T
Q
A
R
E
AY
T
D
--
E
E
R
R
L
T
E
R
R
R
R
L
N
M
MHRSSDEDT
S
L
T
A
T
MSSGSDTSNNGGSAGSAGCSFAEEGERSEHV
D
I
E
SD
L
S
TLSGSDGDVGARSRSVGGPRRHSLGTTWRDQSARASAATE
N
S
E
E
L
L
Q
NTDREVPHHEPACAARVKDPTAP
S
A
S
A
L
S
A
C
R
S
RFPGSDARA
S
T
T
L
A
ATSPTSAHVGSWD
T
S
I
S
L
Y
A
TSPSSSTRGLEAGPQFQRSPH
G
L
V
L
PLPLASSY
P
R
Q
Q
Q
Q
Q
Q
Q
Q
Q
QQRPCPVSP
P
T
R
Q
R
E
V
M
R
R
ELPRDKSRSRGGASFGKSPYD
G
V
V
A
KAAGGVARAPREPGGPVG
V
A
T
T
IRQPAGSSPLSPHTSASAETPPPLSSSPATQS
S
T
I
C
G
A
V
L
S
ERSSSSRTP
P
L
TVGGPHRQTPPQPL
A
T
TTATSSAHS
D
I
V
A
C
P
I
E
W
YTGGSG
R
L
D
VSSATWRTGASGHL
P
K
E
L
S
M
A
Q
K
E
M
Q
E
M
L
DWGTSSDRHHALSSSSPDIGRRSSKALPTATNSAVRGGEGHH
N
H
H
R
L
H
H
L
C
HNHGDDL
D
S
E
C
T
A
E
A
E
S
LS
H
H
ESRGL
S
A
T
E
T
V
A
A
AQQ
P
A
K
R
K
L
W
G
L
G
I
F
R
N
LRSK
49
Fugue
66.37
21%
-16
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
G
P
A
Q
T
N
G
Q
C
F
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
-
N
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
----
L
H
R
E
D
------------
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
-
L
-
K
-
N
A
D
K
-
V
F
A
M
K
--
I
L
N
K
W
E
--
M
L
K
-
R
-
A
-
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
S
K
W
I
T
T
L
H
Y
------
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
-
L
S
K
F
E
D
R
---
L
P
--
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
---
D
M
-
N
G
H
-
I
R
L
A
D
F
G
S
C
L
-
K
L
M
E
D
G
-
T
V
Q
S
S
V
A
V
-
G
T
P
D
Y
I
S
P
E
I
L
---
Q
---
A
M
-----
E
G
-
G
K
G
R
YGP
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
-
P
F
Y
A
E
S
L
V
E
T
Y
G
K
-
I
M
N
H
K
E
R
F
-
Q
---
F
---
P
----------
T
Q
---
V
T
D
V
--
S
E
N
A
K
D
L
I
R
R
L
I
C
S
R
E
--
H
R
L
G
Q
-----
N
G
I
E
D
F
K
K
H
P
F
F
SGI
D
W
D
N
I
R
N
C
E
AP
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
S
G
H
H
L
P
F
V
G
F
T
Y
T
-----
S
S
C
V
L
S
D
R
S
C
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
66.17
35%
-30
- C1 -
-
4USF
1
SLK_HUMAN
A:
[24-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
-
N
-
K
-
E
-
T
S
V
L
A
A
A
K
--
V
I
---
D
--
T
K
S
-
E
-
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
D
-
H
P
N
I
V
K
L
L
D
------
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
-
M
L
E
L
E
-
R
P--
L
T
--
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
---
T
L
-
D
G
D
-
I
K
L
A
D
F
G
V
S
A
K-----------------
T
P
Y
W
M
A
P
E
V
V
---
M
---
C
E
R----
P
Y
-
D
Y
K
A
-----
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
------
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
-
S
---
E
---
P
PTL-------
A
Q
---
P
S
R
W
--
S
S
N
F
K
D
F
L
K
K
--
C
L
E
K
--
N
V
D
A
R
-----
W
T
T
S
Q
L
L
Q
H
P
F
V
---
T
V
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
64.64
27%
1
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
V
DY
E
Y
R
E
EVH
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
-
Q
-
T
-
G
F
-
Q
C
A
V
K
--
K
V
---
R
--
L
E
V
-
F
-
R
-
A
E
E
L
M
-----
A
C
A
G
L
T
S
P
R
I
V
P
L
Y
G
------
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
-
V
K
E
Q
G
-
C
---
L
P
--
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
---
S
S
-
D
G
S
H
A
A
L
C
D
F
G
H
A
---------
V
C
L
Q
I
P
---
G
T
E
T
H
M
A
P
E
V
V
---
L
---
G
R
-----
S
C
-
D
A
K
V
-----
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
------
H
P
W
T
Q
F
F
R
G
-
P
L
C
L
K
I
A
S
-
E
---
P
PPV
R
----------
E
I
---
P
P
S
C
--
A
P
L
T
A
Q
A
I
Q
E
--
G
L
R
K
--
E
P
I
H
R
-----
V
S
A
A
E
L
G
G
K
V
N
R
---
A
L
Q
Q
V
G
G
L
K
-----
S
P
W
R
G
E
Y
K
E
P
R
H
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
64.49
31%
-20
- C1 -
-
5DH3
1
STK3_HUMAN
A:
[21-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
K
Q
P
E
E
V
-------------
F
D
V
L
E
K
L
G
E
G
S
Y
G
S
V
F
K
A
I
-
H
-
K
-
E
S
G
Q
-
V
V
A
I
K
--
Q
V
---
P
--
V
E
--
S
-
D
-
L
Q
E
I
I
K
E
I
S
I
M
Q
Q
C
D
S
-
P
Y
V
V
K
Y
Y
G
------
S
Y
F
K
N
T
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
I
I
R
L
R
N
K
-
T
---
L
I
--
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
D
I
K
A
G
N
I
L
L
---
N
T
-
E
G
H
-
A
K
L
A
D
F
G
V
A
G
-
Q
L
T
D
T
M
-
A
K
R
N
T
V
I--
G
T
P
F
W
M
A
P
E
V
I
---
Q
---
E
I
-----
G
Y
-
N
C
V
A
-----
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
------
P
P
Y
A
D
I
H
P
M
-
R
A
I
F
M
I
P
T
-
N
---
P
---
P
----------
P
T
FRK
P
E
L
W
--
S
D
D
F
T
D
F
V
K
K
--
C
L
V
K
--
N
P
E
Q
R
-----
A
T
A
T
Q
L
L
Q
H
P
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.33
34%
-41
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[6-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
-
N
-
T
-
G
E
-
L
A
A
I
K
--
V
I
---
K
--
L
E
P
-
G
-
E
-
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
H
P
N
I
V
A
Y
F
G
------
S
Y
L
R
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
-
Y
H
V
T
G
-
P
---
L
S
--
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
---
T
D
-
N
G
H
-
V
K
L
A
D
F
G
V
S
A
----
Q
I
T
-
A
T
I
A
--AFI
G
T
P
Y
W
M
A
P
E
V
A
A
V
E
R
---
K
G
-----
G
Y
-
N
Q
L
C
-----
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
------
P
P
M
F
D
L
H
P
M
-
R
A
L
F
L
M
T
K
-
S
N
F
Q
P
---
P
----------
K
L
---
K
D
K
M
KW
S
N
S
F
H
H
F
V
K
M
--
A
L
T
K
--
N
P
K
K
R
-----
P
T
A
E
K
L
L
Q
H
P
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
61.98
18%
-6
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
T
P
-------
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
V
T
------
K
N
T
------------
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
-
V
-
R
-
A
T
G
K
-
M
Y
A
C
K
--
K
L
E
K
K
R
--
I
K
K
-
R
-
K
-
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
N
S
R
F
V
V
S
L
A
Y
------
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
-
I
Y
H
M
G
-
Q
A
G
-
F
P
--
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
---
D
D
-
H
G
H
-
I
R
I
S
D
L
G
L
A
V
-
H
V
P
E
G
Q
-
T
I
K
G
R
V
---
G
T
V
G
Y
M
A
P
E
V
V
---
K
---
N
E
-----
R
Y
-
T
F
S
P
-----
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
--
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
-
E
V
E
R
L
V
K
E
-
V
---
P
---
E
----------
E
Y
---
S
E
R
F
--
S
P
Q
A
R
S
L
C
S
Q
--
L
L
C
K
--
D
P
A
E
R
LGCRG
G
S
A
R
E
V
K
E
H
P
L
F
---
K
K
L
N
F
K
R
L
G
-----
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
ATGS
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
61.08
35%
-13
- C1 -
-
2JFM
2
SLK_HUMAN
A:
[45-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
-
N
-
K
-
E
-
T
S
V
L
A
A
A
K
--
V
I
---
D
--
T
K
S
-
E
-
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
D
-
H
P
N
I
V
K
L
L
D
------
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
-
M
L
E
L
E
-
R
P
--
L
T
--
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
---
T
L
-
D
G
D
-
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
-
R
R
D
S
F
I
---
G
T
P
Y
W
M
A
P
E
V
V
---
M
---
C
E
TSKDR
P
Y
-
D
Y
K
A
-----
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
------
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
-
S
---
E
---
P
PTL-------
A
Q
---
P
S
R
W
--
S
S
N
F
K
D
F
L
K
K
--
C
L
E
K
--
N
V
D
A
R
-----
W
T
T
S
Q
L
L
Q
H
P
F
V
---
T
V
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
60.86
35%
-17
- C1 -
-
2J51
5
SLK_HUMAN
A:
[45-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
-
N
-
K
-
E
-
T
S
V
L
A
A
A
K
--
V
I
---
D
--
T
K
S
-
E
-
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
D
-
H
P
N
I
V
K
L
L
D
------
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
-
M
L
E
L
E
-
R
P--
L
T
--
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
---
T
L
-
D
G
D
-
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
-
R
R
D
S
F
I
---
G
T
P
Y
W
M
A
P
E
V
V
---
M
---
C
E
TSKDR
P
Y
-
D
Y
K
A
-----
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
------
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
-
S
---
E
---
P
PTL-------
A
Q
---
P
S
R
W
--
S
S
N
F
K
D
F
L
K
K
--
C
L
E
K
--
N
V
D
A
R
-----
W
T
T
S
Q
L
L
Q
H
P
F
V
---
T
V
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
60.77
14%
-
- C1 -
-
3QA8
-
?
A:
[16-666]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
K
E
R
L
G
T
G
G
F
G
Y
V
L
R
W
I
-
H
-
Q
-
D
T
G
E
-
Q
V
A
I
K
--
Q
C
---
R
QE
L
S
P
-
K
-
N
-
R
E
R
W
C
L
E
I
Q
I
M
K
K
L
N
-
H
P
N
V
V
S
A
R
E
VPDGLQ
K
L
A
P
N
D
L
P
L
L
A
M
E
Y
C
E
G
G
D
L
R
K
Y
-
L
N
Q
F
E
-
N
CCG
L
K
--
E
G
P
I
R
T
L
L
S
D
I
S
S
A
L
R
Y
L
H
E
N
R
I
I
H
R
D
L
K
P
E
N
I
V
L
QPG
P
Q
-
R
L
I
-
H
K
I
I
D
L
G
Y
A
K
-
E
L
D
Q
G
E
-
L
C
T
E
F
V
---
G
T
L
Q
Y
L
A
P
E
L
L
---
E
---
Q
K
-----
K
Y
-
T
V
T
V
-----
D
Y
W
S
F
G
T
L
A
F
E
C
I
--
T
G
F
R
P
F
L
P
N
W
Q
P
V
Q
W
H
-
G
K
V
R
I
V
V
Y
-
D
---
D
---
L
T
G
A
V
K
F
S
S
VL
P
T
---
P
N
H
L
--
S
G
I
L
A
G
K
L
E
R
--
W
L
Q
C
M
L
M
W
H
Q
R
-----
T
D
P
Q
N
P
N
V
G
C
F
Q
---
A
L
D
S
I
L
S
L
K
-----
L
L
S
V
M
N
M
V
S
G
R
V
H
T
Y
P
V
T
E
N
E
N
L
Q
N
L
K
-----
S
W
L
Q
Q
D
T
G
I
P
E
E
E
Q
E
L
L
Q
A
S
G
L
A
L
N
S
A
Q
P
L
T
Q
Y
V
I
D
C
T
V
G
D
L
I
F
L
F
D
N
R
K
I
S
L
P
A
H
P
E
S
V
S
I
V
L
Q
D
P
K
R
P
L
T
Y
T
H
L
R
R
V
W
G
Q
I
W
Q
T
I
R
A
L
K
E
D
C
A
R
L
L
Q
G
Q
R
T
S
M
V
N
L
L
R
Y
N
T
E
L
S
K
K
K
N
S
M
T
S
E
C
E
Q
L
K
A
K
L
D
F
F
R
S
S
I
Q
I
D
L
E
K
Y
S
E
Q
M
E
F
G
I
T
S
E
K
L
L
S
A
W
R
E
M
E
Q
A
V
E
L
CG
R
E
R
E
V
Q
A
L
V
D
K
M
M
A
L
Q
T
D
S
V
D
L
Q
R
N
P
T
L
D
D
L
E
E
Q
A
R
D
L
Y
R
R
L
R
E
R
P
R
D
Q
R
T
P
G
D
S
N
D
M
V
R
L
L
I
L
A
I
Q
S
F
E
K
R
V
I
L
I
Y
D
Q
L
S
K
T
V
V
C
K
R
K
A
L
E
L
S
P
K
V
K
E
V
M
N
L
M
R
E
D
E
K
I
V
V
R
R
Q
E
K
R
Q
Q
E
L
W
N
L
L
K
I
A
C
S
K
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
60.73
31%
-25
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[94-352]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
------------
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
-
V
-
R
S
S
-
G
K
-
L
V
A
V
K
--
K
M
---
D
--
L
R
K
-
Q
Q
R
-
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
------
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
T
H
T
--
R
---
M
N
--
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
---
T
H
-
D
G
R
-
V
K
L
S
D
F
G
F
C
A
-
Q
V
S
K
E
V
P
R
R
K
S
L
V
---
G
T
P
Y
W
M
A
P
E
L
I
---
S
---
R
L
-----
P
Y
-
G
P
E
V
-----
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
-
E
P
P
Y
F
N
E
P
P
L
K
---
A
-
M
K
M
I
R
D
N
L
P
P
---
R
---
L
----------
K
N
---
L
H
K
V
--
S
P
S
L
K
G
F
L
D
R
--
L
L
V
R
--
D
P
A
Q
R
-----
A
T
A
A
E
L
L
K
H
P
F
L
---
A
K
A
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
60.42
33%
-15
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
------------
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
-
N
V
N
-
T
-
G
E
-
L
A
A
I
K
--
V
I
---
K
--
L
E
P
G
E
-
D
-
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
F
G
------
S
Y
L
R
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
-
Y
H
V
T
G
-
P
---
L
S
--
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
---
T
D
-
N
G
H
-
V
K
L
A
D
F
G
V
S
A
-
Q
I
T
A
T
I
A---
A
F
I
---
G
T
P
Y
W
M
A
P
E
V
A
---
A
V
ER
K
G
-----
G
Y
-
N
Q
L
C
-----
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
-
Q
P
P
M
F
D
L
H
P
M
R
---
A
-
L
F
L
M
T
K
S
N
-
F
Q
--
P
P
K-
L
----------
K
D
---
K
M
K
W
--
S
N
S
F
H
H
F
V
K
M
--
A
L
T
K
--
N
P
K
K
R
-----
P
T
A
E
K
L
L
Q
H
P
F
V
---
T
Q
H
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
60.30
33%
-27
- C1 -
-
5AJQ
2
STK10_HUMAN
A:
[24-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
-
N
-
K
-
E
T
G
A
-
L
A
A
A
K
--
V
I
---
E
------
E
-
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
-
H
P
Y
I
V
K
L
L
G
------
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
-
M
L
E
L
D
-
R
G
--
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
---
T
L
-
E
G
D
-
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
-------
F
I
---
G
T
P
Y
W
M
A
P
E
V
V
---
M
---
C
E
TMKDT
P
Y
-
D
Y
K
A
-----
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
------
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
-
S
D--
P
---
P
----------
T
L
LT-
P
S
K
W
--
S
V
E
F
R
D
F
L
K
I
--
A
L
D
K
--
N
P
E
T
R
-----
P
S
A
A
Q
L
L
E
H
P
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
59.71
33%
-28
- C1 -
-
4AOT
1
STK10_HUMAN
A:
[27-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
-
N
-
K
-
E
T
G
A
-
L
A
A
A
K
--
V
I
---
E
--
T
K
S
-
E
-
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
-
H
P
Y
I
V
K
L
L
G
------
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
-
M
L
E
L
D
-
R
G
--
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
---
T
L
-
E
G
D
-
I
R
L
A
D
F
G
V
S
A
-----------------
G
T
P
Y
W
M
A
P
E
V
V
---
M
-----------
Y
-
D
Y
K
A
-----
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
------
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
-
S
D--
P
---
P
----------
T
L
LT-
P
S
K
W
--
S
V
E
F
R
D
F
L
K
I
--
A
L
D
K
--
N
P
E
T
R
-----
P
S
A
A
Q
L
L
E
H
P
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
59.33
34%
-15
- C1 -
-
2JFL
6
SLK_HUMAN
A:
[45-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
-
N
-
K
-
E
-
T
S
V
L
A
A
A
K
--
V
I
---
D
--
T
K
S
-
E
-
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
D
-
H
P
N
I
V
K
L
L
D
------
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
-
M
L
E
L
E
-
R
P
--
L
T
--
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
---
T
L
-
D
G
D
-
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
-
R
R
D
S
F
I
---
G
T
P
Y
W
M
A
P
E
V
V
---
M
---
C
E
TSKDR
P
Y
-
D
Y
K
A
-----
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
------
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
-
S
---
E
---
P
PTL-------
A
Q
---
P
S
R
W
--
S
S
N
F
K
D
F
L
K
K
--
C
L
E
K
--
N
V
D
A
R
-----
W
T
T
S
Q
L
L
Q
H
P
F
V
---
T
V
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
58.20
31%
7
- C1 -
-
4O27
1
STK24_HUMAN
B:
[8-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
-
D
-
N
R
T
-
Q
K
-
V
V
A
I
K
I
I
D
L
---
E
--
E
A
E
-
D
-
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
------
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
E
P
-
G
-
P
---
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
---
S
E
-
H
G
E
-
V
K
L
A
D
F
G
V
A
G
-
Q
L
T
D
T
Q
-
I
K
R
N
E
F
V
--
G
T
P
F
W
M
A
P
E
V
I
---
K
---
Q
S
-----
A
Y
-
D
S
K
A
-----
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
------
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
-
N
---
P
---
P
----------
T
L
---
E
G
N
Y
--
S
K
P
L
K
E
F
V
E
A
--
C
L
N
K
--
E
P
S
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
I
---
L
R
N
A
K
K
T
S
Y
-----
L
T
E
L
I
D
R
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
56.07
32%
-15
- C1 -
-
4LGD
1
STK3_HUMAN
A:
[34-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
S
Y
G
S
V
F
K
A
I
-
H
-
K
-
E
S
G
Q
-
V
V
A
I
K
--
Q
V
---
P
--
V
E
--
S
-
D
-
L
Q
E
I
I
K
E
I
S
I
M
Q
Q
C
D
S
-
P
Y
V
V
K
Y
Y
G
------
S
Y
F
K
N
T
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
I
I
R
L
R
N
K
-
T
---
L
I
--
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
N
I
K
A
G
N
I
L
L
---
N
T
-
E
G
H
-
A
K
L
A
D
F
G
V
A
G
-
Q
L
T
D
T
M
-
A
K
R
N
T
V
I
--
G
T
P
F
W
M
A
P
E
V
I
---
Q
---
E
I
-----
G
Y
-
N
C
V
A
-----
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
------
P
P
Y
A
D
I
H
P
M
-
R
A
I
F
M
I
P
T
-
N
---
P
---
P
----------
P
T
FRK
P
E
L
W
--
S
D
D
F
T
D
F
V
K
K
--
C
L
V
K
--
N
P
E
Q
R
-----
A
T
A
T
Q
L
L
Q
H
P
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
55.67
33%
-25
- C1 -
-
2J7T
1
STK10_HUMAN
A:
[27-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
-
N
-
K
-
E
T
G
A
-
L
A
A
A
K
--
V
I
---
E
--------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
-
H
P
Y
I
V
K
L
L
G
------
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
-
M
L
E
L
D
-
R
G
--
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
---
T
L
-
E
G
D
-
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
-
K
--------
G
T
P
Y
W
M
A
P
E
V
V
---
M
---
C
E
T
M
K
D
T
P
Y
-
D
Y
K
A
-----
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
------
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
-
S
D--
P
---
P
----------
T
L
LT-
P
S
K
W
--
S
V
E
F
R
D
F
L
K
I
--
A
L
D
K
--
N
P
E
T
R
-----
P
S
A
A
Q
L
L
E
H
P
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
55.59
36%
-13
- C1 -
-
5UOR
1
M3K5_HUMAN
A:
[17-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
-
S
-
N
-
Q
V
-
R
I
A
I
K
--
E
I
---
P
--
E
R
D
-
S
-
R
-
Y
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
------
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
-
P
---
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
---
N
T
Y
S
G
V
-
L
K
I
S
D
F
G
T
S
K
-
R
L
-------
F
T
-----
G
T
L
Q
Y
M
A
P
E
I
I
---
D
------------Y
G
K
A
A
-----
D
I
W
S
L
G
C
T
I
I
E
M
A
--
T
G
K
P
P
F
Y
E
-------
A
-
M
F
K
V
G
M
F
K
-
V
---
H
---
P
----------
E
I
---
P
E
S
M
--
S
A
E
A
K
A
F
I
L
K
--
C
F
E
P
--
D
P
D
K
R
-----
A
C
A
N
D
L
L
V
D
E
F
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
54.92
33%
11
- C1 -
-
2XIK
2
STK25_HUMAN
A:
[21-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
-
D
-
N
H
T
-
K
E
-
V
V
A
I
K
I
I
D
L
---
E
--
E
A
E
---
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
I
T
R
Y
F
G
------
S
Y
L
K
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
K
P
-
G
-
P
---
L
E
--
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
---
S
E
-
Q
G
D
-
V
K
L
A
D
F
G
V
A
G
-
Q
L
T
D
T
Q
-
I
K
R
N
T
F
V--
G
T
P
F
W
M
A
P
E
V
I
---
K
---
Q
S
-----
A
Y
-
D
F
K
A
-----
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
------
P
P
N
S
D
L
H
P
M
R
V
L
F
L
I
P
K
N
-
S
---
P
---
P
----------
T
L
---
E
G
Q
H
--
S
K
P
F
K
E
F
V
E
A
--
C
L
N
K
--
D
P
R
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
I
---
T
R
Y
T
K
K
T
S
F
-----
L
T
E
L
I
D
R
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
54.70
33%
-16
- C1 -
-
4NZW
1
STK25_HUMAN
B:
[22-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
-
D
-
N
H
T
-
K
E
-
V
V
A
I
K
I
I
D
L
---
E
--
E
A
E
-
D
-
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
I
T
R
Y
F
G
------
S
Y
L
K
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
K
P
-
G
-
P
---
L
E
--
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
---
S
E
-
Q
G
D
-
V
K
L
A
A
F
G
V
A
G
------------------
T
P
F
W
M
A
P
E
V
I
---
K
---
Q
-------
Y
-
D
F
K
A
-----
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
------
P
P
N
S
D
L
H
P
M
R
V
L
F
L
I
P
K
N
-
S
---
P
---
P
----------
T
L
---
E
G
Q
H
--
S
K
P
F
K
E
F
V
E
A
--
C
L
N
K
--
D
P
R
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
I
---
T
R
Y
T
K
K
T
S
F
-----
L
T
E
L
I
D
R
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------