@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_28_0660: (2018-03-11 )
MNNYVLNDEIGQGAFSTIYKGRYRTTTEFYAIASIDKKRRERVVNCVQLLRSMHHSNVIEFHNWYETNNHLWIITEYCTGGDMSTILRSNINLTTQAVQAFGRDVAMGLMHIHSKGVVYNDLQTRNLLMDSAAMLRFHDFSLACLFHDAATRPLVGTPLYMAPELFMEDRPLYSMASDLWSFGCVLHELATGKPPFAASDLETLLNDILTSPTPTVPGAPESFQTLLCGLLEKDPLKRYTWADVVRSEFWDEPLPLPSNGFPSQVAWEDYRRSRSGRAASQYNWTDADVRAAVAHAVAAAKSNASTHNVEERERAAATLNVAKELDFTASAAMLLERLPERTQERAAHTTIHVTTAHGSLVPGCPSTASAASNTFNANGSSSSAVASSRRSRLSESKNSGGDPQRHRVSKGRGAASSRASGSAAIAYEGGRTAYATNSGAKEDRPTEANLHLFASEALRHLTISDLLPHHTDQHIRPLSNNSRIEYTPEPSYDISTLGFTALTAAEINSLTGKEHTAFFRSLYLALSNLSSGYDNVLNTMNYVISLCGDAEVARASVNSSVMRLCVKHAGRKDAPAGFRAAAALIMGLLVRTTAFITSEVASSSILPDIMQLFEDETDVPVKRKLIACIGEFLFYIAVQQKRQRAMWNVQPATVKRIYTWALDSDDDVLKHYAAKMIENMASTPQKEMTLELFADPVFVEKLLAVFALPSVEGRSEDMRSDAVCAAFKLAMVKDELILAVMQCRWLPVTSYATVMQRSTLTHPMQILLTFLNYAIVKGLVTLQSPFARLWSQASFDSHSSGGCGSGRRGCALTSSLSVEDAEEVVGNALFVSEDLLEHLSEAIEQASVAVYGKTLLFVMLIGCVGGSTICQILNSRIVAFLDRLVRDADSYVKRCGAALSAFLGWFVSEKLASIARRVSSTSTATHLAAIQQLLNSSAVRSGIDFQKDVFQSLSTCIDKAMNNTIYGTYRDEFNRIADRFVESPEEVLRYQENICLYLATSYAEMLRRKEASGRFTAIRFLTSAMVPISAEVTATRKESSGATSAARQVLNAVAPNVASLLQETSPIPTNTMRLLVTCGEMAQSKLSGLVSEQLLGHIMDYVNGSGDGGDMYYPLSFIHLCLLVSQRVDIFNYVVRQGLCALALETLASAATGRNEPLVEMCCNLLAVVVRRVAGDSSSRVTAQCASCVQADSISSVLLPICADTANSIALMESAASVIEDFARLSSTARNDLTSASAIAMWAGALSNALLSSARRAVAVSLLTALSTSCESTSRDVLEELKCDSRVMSVLANAADCTHMRLVASEANKILKKLS
Atome Classification :
(20 SA)
---------------------------.........10........20........30....---.----..--.------------40........50-..-----.-.....60........70------........80....-....90.---.......100.......110..-.....120.......---130----.----......140.--.-...--.-.--150.......160.......----170.......180.......190.......200--........----210---.-----.......220........230.......-----240.......250.......260.......270.......280.......290.......300.......310.-......320.......330.......340.......350.......360----........370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510----.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------------------MN
N
Y
V
LNDEIG
Q
G
A
F
S
T
I
YKGR
Y
R
T
T
T
E
F
Y
A
IASI---
D
----
K
K
--
R
------------
R
E
R
V
V
N
C
V
Q
L
L
R
-
S
M
-----
H
-HS
N
V
I
E
F
H
N
W
Y
ETNN
H
L
------
W
I
I
T
EYCTGG
D
M
S
T
-
I
L
R
SNIN---
L
T
T
Q
A
V
Q
A
F
G
R
D
V
A
M
G
L
M
H
IHS-KG
V
V
YNDL
Q
T
R
N
L
L
M
---
D
S
A
----
A
----
M
L
R
FHD
F
S
L
A
--
C
-
L
FH--D-A--ATRPLVGTPLYMA
P
E
L
F
MED----R
P
L
Y
S
M
A
S
D
L
W
S
F
G
C
V
L
H
E
LATGKPPF
A
A
S
D
L
---
E
T
L
L
N
D
IL----TS----P-----TPTVPGA
P
E
-
S
F
Q
T
L
L
C
G
L
LEKDPLK
R
Y
-----
T
W
A
D
V
V
R
S
EFWDEPLPLPSNGFPSQ
V
A
W
E
D
Y
R
R
SRSGRAASQYNWT
D
A
D
V
R
A
A
V
A
H
A
V
A
AAKSNASTH
N
V
E
E
R
E
-
R
A
A
A
T
L
N
V
A
K
ELDF
T
A
S
A
A
M
L
L
E
R
L
P
E
R
T
Q
ERAA
H
T
T
I
H
V
TTAHGSLV-----PGCPSTASAASNTFNANGSS
S
S
A
V
A
S
S
R
R
S
R
L
SESKNSGGDP
Q
R
HRVSKGRGAASSRASG
S
A
A
I
A
YEGG
R
T
A
YATNSGAKEDRPTEA
N
L
H
L
F
A
S
E
A
L
R
H
L
T
I
S
D
LLPHHTDQHIRPLSNNS
R
I
E
YTPEPSYDI
S
T
L
G
F
T
A
L
T
A
A
E
I
N
S
LTG----
K
E
H
T
A
F
F
R
S
L
Y
L
A
L
S
N
LSS
G
Y
D
N
V
L
N
T
M
N
Y
V
I
S
LCGD
A
E
V
A
R
A
SV
N
S
S
V
M
R
L
C
V
K
HAGRKDAP
A
G
F
R
A
A
A
A
L
I
M
G
L
L
V
R
T
T
A
F
I
T
S
E
VASSSI
L
P
D
I
M
Q
L
FEDETDV
P
V
K
R
K
L
I
A
C
I
G
E
F
L
F
Y
I
A
V
Q
Q
K
R
Q
R
AMWNVQPA
T
V
K
R
I
Y
T
W
ALDS
D
D
D
V
L
K
H
Y
A
A
K
M
I
E
N
M
ASTPQK
E
M
T
L
E
LFA
D
P
V
F
V
E
K
L
L
A
V
F
ALPSVEGR
S
E
D
M
R
S
D
A
V
C
A
A
F
K
L
A
M
V
K
D
E
L
I
L
A
V
M
QCRWLP
V
T
S
Y
A
T
V
M
Q
RSTL
T
H
P
M
Q
I
L
L
T
F
L
N
Y
A
I
V
K
G
L
V
T
L
Q
S
P
F
A
R
L
W
S
QASFDSHSSGGCGSGRRG
C
A
LTSSLS
V
E
D
A
E
E
V
VGN
A
L
F
V
S
E
D
L
L
E
H
L
S
E
A
I
E
Q
A
S
V
A
V
Y
G
K
T
L
L
F
V
M
L
I
G
CV
G
G
S
T
I
C
Q
I
L
N
S
R
I
V
A
F
L
D
R
L
V
R
D
A
D
S
Y
V
K
R
C
G
A
A
L
S
A
F
L
G
W
F
V
S
E
K
L
A
S
I
A
R
R
VSSTS
T
A
T
H
L
A
A
I
Q
Q
L
L
N
S
S
A
V
RSGI
D
F
Q
K
D
V
F
Q
S
L
S
T
C
I
D
K
A
MNN
T
I
Y
G
T
Y
R
D
E
F
N
R
I
A
D
R
F
VE
S
P
E
E
V
L
R
Y
Q
EN
I
C
L
Y
L
A
T
S
Y
A
E
M
L
R
R
KEASG
R
F
T
A
I
R
F
L
T
S
AMVPI
S
A
E
V
T
A
TRKESSG
A
T
S
A
A
R
Q
V
L
N
A
V
A
P
N
V
A
S
L
L
Q
ETSPIPTN
T
M
R
L
L
V
T
C
G
E
M
A
Q
S
K
L
S
G
L
V
S
E
Q
L
L
G
H
I
M
D
Y
VNGSGDGG
D
M
Y
Y
P
L
S
F
I
H
L
C
L
L
V
SQ
R
V
D
I
F
N
Y
V
V
R
Q
G
L
C
A
L
A
L
E
T
L
A
S
AATGRNE
P
L
V
E
M
C
C
N
L
L
A
V
V
V
R
R
VAGDSSS
R
V
T
A
Q
C
A
S
C
V
Q
A
D
S
I
S
S
V
L
L
P
ICADTA
N
S
I
A
L
M
E
S
A
A
S
V
I
E
D
F
A
R
L
S
S
T
ARNDLT
S
A
S
A
I
A
M
W
A
G
A
L
S
N
A
L
L
S
S
A
R
R
A
V
A
V
S
L
L
T
A
L
S
TSCES
T
S
R
D
V
L
E
E
LKC
D
S
R
V
M
S
V
L
ANAADC
T
H
M
R
L
V
A
S
E
A
N
K
I
L
K
KLS
32
HHSearch
80.04
26%
-37
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[8-275]
----------------------------
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
---
K
----
K
E
--
V
I
V
A
K
DE------
V
A
H
T
L
T
E
N
R
V
L
Q
-
N
S
-----
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
------
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
-
H
L
S
R
E
R
V
---
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
---
D
K
D
----
G
----
H
I
K
I
T
D
F
G
L
C
--
K
-
E
G
I
--
K
-
D
GA
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
----
D
--
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
---
E
K
L
F
E
L
I
L
----
M
E
----
E
-----
I
R
F
P
R
T
L
G
P
-
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
77.26
26%
-26
- C1 -
-
2PHK
2
PHKG1_RABIT
A:
[4-276]
----------------------------
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
---
D
----
V
T
--
G
GGSFS
A
E
E
V
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
-
K
V
-----
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
------
F
L
V
F
D
L
M
K
K
G
E
L
F
D
-
Y
L
T
E
K
V
T
---
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
-
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
D
D
----
M
----
N
I
K
L
T
D
F
G
F
S
--
C
-
Q
L
D
--
P
-
G
E
-
K
L
R
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
DN
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
Q
---
M
L
M
L
R
M
I
M
----
S
G
----
N
YQFG-
S
P
E
W
D
D
Y
S
D
-
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
-----
T
A
E
E
A
L
A
H
P
F
F
Q
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
75.26
14%
-
- C1 -
-
3QA8
-
?
A:
[16-666]
-------------------------------
E
M
K
E
R
L
G
T
G
G
F
G
Y
V
L
R
W
I
H
Q
D
T
G
E
Q
V
A
I
K
Q
C
---
R
QELS
P
K
--
N
------------
R
E
R
W
C
L
E
I
Q
I
M
K
-
K
L
-----
N
-
H
P
N
V
V
S
A
R
E
V
P
D
G
L
Q
K
L
APND
L
P
L
L
A
M
E
Y
C
E
G
G
D
L
R
K
-
Y
L
N
Q
F
E
N
CCG
L
K
E
G
P
I
R
T
L
L
S
D
I
S
S
A
L
R
Y
L
H
E
-
N
R
I
I
H
R
D
L
K
P
E
N
I
V
L
QPG
P
Q
R
----
L
----
I
H
K
I
I
D
L
G
Y
A
--
K
E
L
D
Q
--
G
-
E
--
L
C
T
E
F
V
G
T
L
Q
Y
L
A
P
E
L
L
E
Q
K
----
K
--
Y
T
V
T
V
D
Y
W
S
F
G
T
L
A
F
E
C
I
T
G
F
R
P
F
L
P
N
W
Q
---
P
V
Q
W
H
G
K
V
----
R
I
----
V
-----
V
Y
D
D
L
T
G
A
V
-
K
F
S
S
----------------------
V
L
P
T
P
N
H
L
S
G
I
L
A
G
K
L
E
R
W
L
Q
C
M
L
M
W
H
Q
R
T
D
P
Q
N
P
N
V
G
C
F
Q
A
L
D
S
I
L
S
L
K
L
L
S
V
M
N
M
V
S
G
R
V
H
T
Y
P
V
T
E
N
E
N
L
Q
N
L
K
S
W
L
Q
Q
D
T
G
I
P
E
E
E
Q
E
L
L
Q
A
S
G
L
A
L
N
S
A
Q
P
L
T
Q
Y
V
I
D
C
T
V
G
D
L
I
F
L
F
DN
R
K
I
S
L
P
A
H
P
E
S
V
S
I
V
L
Q
D
P
K
R
P
L
T
Y
T
H
L
R
R
V
W
G
Q
I
W
Q
T
I
R
A
L
K
E
D
C
A
R
L
L
Q
G
Q
R
T
S
M
V
N
L
L
R
Y
N
T
E
L
S
K
K
K
N
S
M
T
S
E
C
E
Q
L
K
A
K
L
D
F
F
R
S
S
I
Q
I
D
L
E
K
Y
S
E
Q
M
E
F
G
I
T
S
E
K
L
L
S
A
W
R
E
M
E
Q
A
V
E
L
C
G
R
E
R
E
V
Q
A
L
V
D
K
M
M
A
L
Q
T
D
S
V
D
L
Q
R
NPT
L
D
D
L
E
E
Q
A
R
D
L
Y
R
R
L
R
E
R
P
R
D
Q
R
T
P
G
D
S
N
D
M
V
R
L
L
I
L
A
I
Q
S
F
E
K
R
V
I
L
I
Y
D
Q
L
S
K
T
V
V
C
K
R
K
A
L
E
L
S
P
K
V
K
E
V
M
N
L
M
R
E
D
E
K
I
V
V
R
R
Q
E
K
R
Q
Q
E
L
W
N
L
L
K
I
A
C
S
K
V
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
72.32
26%
-4
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[94-364]
----------------------------
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
---
E
----
V
T
--
A
ERLSPEQLEEV-
R
E
A
T
R
R
E
T
H
I
L
R
-
Q
V
A----
G
-
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
------
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
V
A
---
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
D
N
----
M
----
Q
I
R
L
S
D
F
G
F
S
--
C
-
H
L
E
--
P
-
G
E-
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
MDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
---
I
L
M
L
R
M
I
M
----
E
G
----
Q
YQFS-
S
P
E
W
D
D
R
S
S
-
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
72.25
25%
-22
* C1 *
-
5K00
1
MELK_HUMAN
A:
[8-265]
----------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
---
D
----
K
N
--
T
LGSD--------
L
P
R
I
K
T
E
I
E
A
L
K
-
N
L
-----
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
------
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
----
H
----
K
L
K
L
I
D
F
G
L
C
--
A
-
K
P
---------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
----
S
-
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
---
M
A
L
Y
K
K
I
M
----
R
G
----
K
-----
Y
D
V
P
K
W
L
S
P
-
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
71.72
26%
-17
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[94-364]
----------------------------
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
---
E
----
V
----RLSPEQLEEV--
R
E
A
T
R
R
E
T
H
I
L
R
-
Q
V
A----
G
-
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
------
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
V
A
---
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
D
N
----
M
----
Q
I
R
L
S
D
F
G
F
S
--
C
-
H
L
E
--
P
-
G
E-
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
MDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
---
I
L
M
L
R
M
I
M
----
E
G
----
Q
YQFS-
S
P
E
W
D
D
R
S
S
-
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
71.54
20%
5
- C1 -
-
1KOB
1
?
A:
[23-374]
INDYDKFYEDIWKK
Y
V
P
Q
P
V
E
V
K
QGS
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
----
P
L
--
D
------------
K
Y
T
V
K
N
E
I
S
I
M
N
-
Q
L
-----
H
-
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
------
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
Y
K
---
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
-
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
ET-
K
K
A
----
S
----
S
V
K
I
I
D
F
G
L
A
--
T
-
K
L
N
P-
D
-
E
--
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
--
D
----
R
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
D
D
---
L
E
T
L
Q
N
V
K
R
C
D
W
E
F
----
D
-----
E
D
A
F
S
S
V
S
P
-
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
-----
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
-
K
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
71.34
23%
-18
- C1 -
-
5L8L
4
AURKA_HUMAN
A:
[12-271]
---------------------------
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
---
F
----
K
A
--
Q
L
E
K
A
GV------
E
H
Q
L
R
R
E
V
E
I
Q
S
-
H
L
-----
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
------
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
---
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
A
----
G
----
E
L
K
I
A
D
F
G
W
S
--
V
-
H
A
P
--
S
-
S
--
R
R
T
T
L
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
----
M
--
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
---
Q
E
T
Y
K
R
I
S
----
R
V
----
E
-----
F
T
F
P
D
F
V
T
E
-
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
71.11
26%
0
- C- -
-
1XJD
1
A:
[16-321]
---------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
A
L
---
K
----
K
D
V
V
L
------------
M
D
D
D
V
E
C
T
M
V
E
K
-
R
V
L
S
L
A
W
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
------
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
-
H
I
Q
S
C
H
K
---
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
---
D
K
D
----
G
----
H
I
K
I
A
D
F
G
M
C
KE
N
-
M
L
G
--
D
-
A
--
K
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
----
K
--
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
---
E
E
L
F
H
S
I
R
----
M
D
----------
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
-----
G
----
V
R
G
D
I
R
Q
H
P
L
-------
F
R
E
I
N
W
E
E
L
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
70.10
26%
-16
- C- -
-
3FE3
-
MARK3_HUMAN
B:
[53-310]
---------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
---
D
----
K
T
--
Q
LNPTS-------
L
Q
K
L
F
R
E
V
R
I
M
K
-
I
L
-----
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
------
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
-
Y
L
V
A
H
G
R
---
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
D
----
M
----
N
I
K
I
A
D
F
G
F
S
--
N
-
E
F
T
--
V
-
G
G-
K
L
D
A
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
K
----
K
-
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
---
K
E
L
R
E
R
V
L
----
R
G
----
K
-----
Y
R
I
P
F
Y
M
S
T
-
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
I
N
A
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.75
27%
-9
- C1 -
-
4I5P
1
PLK2_HUMAN
A:
[30-284]
------------------------------
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
---
P
----
H
S
--
R
VSK
P
H
Q
------
R
E
K
I
D
K
E
I
E
L
H
R
-
I
L
-----
H
-
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
------
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
-
I
L
K
A
R
K
V
---
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
---
N
E
S
----
M
----
E
L
K
V
G
D
F
G
L
A
--
A
-
R
L
E
PL
E
-
H
--
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
--
N
----
K
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
---
K
E
T
Y
R
S
I
R
----
E
A
RY--
T
-----
M
P
S
S
L
L
A
P
A
---
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
-----
S
L
D
D
I
I
R
H
D
F
F
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
69.69
27%
-12
- C1 -
-
4I6B
1
PLK2_HUMAN
A:
[30-284]
------------------------------
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
---
P
----
H
S
--
R
VSK
P
H
Q
------
R
E
K
I
D
K
E
I
E
L
H
R
-
I
L
-----
H
-
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
------
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
-
I
L
K
A
R
K
V
---
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
---
N
E
S
----
M
----
E
L
K
V
G
D
F
G
L
A
--
A
-
R
L
E
PL
E
-
H
--
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
--
N
----
K
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
---
K
E
T
Y
R
S
I
R
----
E
A
RY--
T
-----
M
P
S
S
L
L
A
P
A
---
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
-----
S
L
D
D
I
I
R
H
D
F
F
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
68.94
26%
2
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[13-280]
----------------------------
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
----
K
R
--
R
TKSSRRGVS---
R
E
D
I
E
R
E
V
S
I
L
K
-
E
I
-----
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
------
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
----
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
--
H
-
K
I
D
--
F
G
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
----
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
---
Q
E
T
L
A
N
V
S
----
A
V
NYEF
E
-----
D
E
Y
F
S
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
68.75
26%
-34
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-268]
----------------------------
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
---
K
----
L
E
--
P
GED---------
F
A
V
V
Q
Q
E
I
I
M
M
K
-
D
C
-----
K
-
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
D
K
L
------
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
-
I
Y
H
V
T
G
P
---
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
-
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
---
T
D
N
----
G
----
H
V
K
L
A
D
F
G
V
S
--
A
-
Q
I
T
--
A
-
T
IA---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
E
R---
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
---
M
R
A
L
F
L
M
T
----
K
S
----
N
F
Q
P
P
K
L
K
D
K
M
K
W
S
N
-
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
-----
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
68.64
27%
8
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[11-277]
----------------------------
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
----
K
R
--
R
TKSSRRGVS---
R
E
D
I
E
R
E
V
S
I
L
K
-
E
I
-----
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
------
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
NVP
K
P
----
R
I
K
I
I
D
F
G
L
A
--
H
-
K
I
D
--
F
G
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
----
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
---
Q
E
T
L
A
N
V
S
----
A
V
NYEF
E
-----
D
E
Y
F
S
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
67.70
24%
-34
- C1 -
-
4NIF
-
KS6A1_HUMAN
A:
[8-271]
----------------------------
D
G
Y
V
V
K
E
T
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
K
A
T
N
M
E
Y
A
V
K
V
I
---
D
----
K
S
--
K
-------------
R
D
P
S
E
E
I
E
I
L
L
R
Y
G
-----
Q
-
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
H
V
------
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
-
K
I
L
R
Q
K
F
---
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
-
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
---
V
D
E
----
S
GNPE
C
L
R
I
C
D
F
G
F
A
--
K
-
Q
L
R
--
A
-
E
NG
L
L
M
T
P
C
Y
---
F
V
A
P
E
V
L
K
R
Q
----
G
--
Y
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
F
A
N
G
P
S
DT
P
E
E
I
L
T
R
I
G
----
S
G
----
K
FTLS-
G
G
N
W
N
T
V
S
E
-
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
-----
T
A
K
Q
V
L
Q
H
P
W
V
T
Q
K
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
67.59
27%
-11
- C1 -
-
4I6F
1
PLK2_HUMAN
A:
[30-284]
------------------------------
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
---
P
----
H
S
--
R
VSK
P
H
Q
------
R
E
K
I
D
K
E
I
E
L
H
R
-
I
L
-----
H
-
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
------
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
-
I
L
K
A
R
K
V
---
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
---
N
E
S
----
M
----
E
L
K
V
G
D
F
G
L
A
--
A
-
R
L
E
PL
E
-
H
--
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
--
N
----
K
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
---
K
E
T
Y
R
S
I
R
----
E
A
RY--
T
-----
M
P
S
S
L
L
A
P
A
---
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
-----
S
L
D
D
I
I
R
H
D
F
F
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
67.46
27%
-6
- C1 -
-
4I6H
1
PLK2_HUMAN
A:
[30-284]
------------------------------
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
---
P
----
H
S
--
R
VSK
P
H
Q
------
R
E
K
I
D
K
E
I
E
L
H
R
-
I
L
-----
H
-
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
------
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
-
I
L
K
A
R
K
V
---
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
---
N
E
S
----
M
----
E
L
K
V
G
D
F
G
L
A
--
A
-
R
L
E
PL
E
-
H
--
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
--
N
----
K
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
---
K
E
T
Y
R
S
I
R
----
E
A
R
Y
--
T
-----
M
P
S
S
L
L
A
P
A
---
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
-----
S
L
D
D
I
I
R
H
D
F
F
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
67.26
23%
-17
- C1 -
-
3H10
1
AURKA_HUMAN
A:
[7-264]
---------------------------
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
---
F
----
K
A
--
Q
L
E
K
A
GV------
E
H
Q
L
R
R
E
V
E
I
Q
S
-
H
L
-----
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
------
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
---
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
A
----
G
----
E
L
K
I
A
D
F
G
W
S
--
V
-
H
A
P
--
S
-
S
--
R
R
A
A
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
----
M
--
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
---
Q
E
T
Y
K
R
I
S
----
R
V
----
E
-----
F
T
F
P
D
F
V
T
E
-
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
66.81
27%
-18
- C1 -
-
4I5M
1
PLK2_HUMAN
A:
[30-284]
------------------------------
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
---
P
----
H
S
--
R
VSK
P
H
Q
------
R
E
K
I
D
K
E
I
E
L
H
R
-
I
L
-----
H
-
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
------
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
-
I
L
K
A
R
K
V
---
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
---
N
E
S
----
M
----
E
L
K
V
G
D
F
G
L
A
--
A
-
R
L
E
--------------
T
P
N
Y
L
S
P
E
V
L
--
N
----
K
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
---
K
E
T
Y
R
S
I
R
----
E
A
R
Y
--
T
-----
M
P
S
S
L
L
A
P
A
---
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
-----
S
L
D
D
I
I
R
H
D
F
F
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------