@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_29_0250: (2018-03-11 )
MRFAKDAELLQYMVPGSTLADIVSSEEDADDYDAYFDAPAAKAEGVSGVVPGEGSAGTGTNAQGVATSLSKFQPAQHKNADAKVLGRIHIDDYYDGHGSGGGASGGAQSNQRVLNELRDMTMSSRFAQNAASKNVDRSERATVENVLDPRTRLILYKLVNSGILSEINGCVSTGKEANVYYAVSGDGSPAALKVYKTSILSFKDRDQYVSGEFRFQRYCKSNPRKMVRTWAEKEARNLIRLQDGGVLAPAVKLLRQHVLIMEFLGEDGWPAPRLKEVTFPSAKALDKCYLDLCCTMRKMYARSHLIHGDLSEYNLLLYRGRVVVIDVSQSVEYDHPRSMSFLRRDIVNVNSFFRSRGLTGLFTLQDLFHFITADPAKSGWQRCQGPPNDEELMARLKEIRDDYGEGGAVPVDAEQAKVDEQVFLNITVPRSLNEICDRAGPNKEVAVFVEGMTAAPAAAQTEDHSGADGEGDGDGDDEDSEADDADSPMKAKAAPQAVLANMTKEERKEHRKAVKEANREKRAEKKKNNANRKKKGRK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.....---..120.......130.....--..140.......150.......160........170.......180..-.--....190.--.--.......200..-.....210.......220.......230.......240-..-..----.-..-250---------.----.----.-.-----...260.......270..-..--.--------.---..280.....--..290...-....300.......310.......-320-........330.....----------.-------------.340-----.-.---......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRFA
K
D
A
E
L
L
Q
Y
MVPG
S
T
L
A
D
I
VSSEEDAD
D
Y
D
A
YFDAPAAKAEGV
S
G
VVPGEGSAGTGTN
A
Q
G
V
A
T
S
L
S
KFQPAQHKNAD
A
K
V
L
G
R
I
H
I
DDYYDGHGSGGGASGGAQ
S
N
Q
R
V
L
N
E
L
---
R
D
M
T
M
S
S
R
F
A
Q
N
AASKNVD
R
--
S
E
R
A
T
V
E
N
VLDP
R
T
R
L
I
L
Y
K
L
V
N-S
G
I
L
S
E
I
N
G
C
VSTGKEA
N
V
Y
Y
A
VS-G--DGS
P
A
--
A
--
L
--
K
V
Y
K
T
SILSFKD-RDQYVS
G
E
F
R
F
Q
R
Y
C
KSN
P
R
K
M
V
R
T
W
A
E
K
E
A
R
N
L
I
RLQ-DG-G
V
----
L
-
A
P
-
A
V
K
---------
L
----
L
----
R
-
Q
-----
H
V
L
I
M
E
F
LGEDGWPA-PR-LK--E--------V---TFP
S
A
K
A
L
D
K
--
C
Y
L
D
L
C
C
T
-
M
R
K
M
Y
A
R
SHLIHGDLSEY
N
L
L
L
YR-G
R
--
V
V
V
I
DVSQSVEYDHP
R
----------
S
-------------
M
S
F
------
L
-
R
---
R
D
I
V
N
V
N
S
F
F
R
SRGL
T
G
L
F
T
L
Q
D
L
F
H
F
ITADP
A
K
S
G
W
Q
RCQGPP
N
D
E
E
L
M
A
R
L
K
E
I
R
D
DYGEGGAVPVD
A
E
QAKVD
E
Q
V
F
L
N
I
TVP
R
S
L
N
E
I
C
DRAGPNK
E
V
A
V
F
V
EGMTAAPAAAQTEDHSGADGEGDGDGDDEDSEADDADSPMKAKA
A
P
Q
A
V
L
A
N
M
T
K
E
E
R
K
E
H
R
K
A
V
K
E
A
N
R
E
K
R
A
E
K
KKNNANRKKKGRK
2
PsiBlast_PDB
80.83
37%
-23
- C3 -
-
4JIN
1
RIO1_ARCFU
A:
[5-248]
---------------------------------------------------------------------------------------------------------------------------
K
K
I
E
S
Y
L
D
K
L
R
I
K
E
K
D
G
--
E
E
R
K
I
Y
A
E
V
L
D
G
R
T
L
K
T
L
Y
K
L
S
A
-
K
G
Y
I
T
A
M
G
G
V
I
S
T
G
K
E
A
N
V
F
Y
A
D
G
V
F
--
D
G
K
P
V
--
A
--
M
A
V
K
I
Y
R
I
E
T
S
E
F
D
K
-
M
D
E
Y
L
Y
G
D
E
R
F
D
M
-
R
R
I
S
P
K
E
K
V
F
I
W
T
E
K
E
F
R
N
L
E
R
A
K
-
E
A
-
G
V
----
S
-
V
P
-
Q
P
Y
---------
T
----
Y
----
M
-
K
-----
N
V
L
L
M
E
F
I
G
E
D
E
L
P
A
-
P
T
-
L
V
--
E
--------
L
---
G
-
R
E
L
K
E
L
D
V
E
G
I
F
N
D
V
V
E
N
-
V
K
R
L
Y
Q
E
A
E
L
V
H
A
D
L
S
E
Y
N
-
I
M
Y
I
-
D
K
--
V
Y
F
I
D
M
G
Q
A
V
T
L
R
H
P
M
----------
A
-------------
E
S
Y
------
L
-
E
---
R
D
V
R
N
I
I
R
F
F
S
K
Y
G
V
K
A
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
79.60
37%
-19
- C3 -
-
1ZTF
1
RIO1_ARCFU
A:
[5-248]
---------------------------------------------------------------------------------------------------------------------------
K
K
I
E
S
Y
L
D
K
L
R
I
K
E
K
D
G
--
E
E
R
K
I
Y
A
E
V
L
D
G
R
T
L
K
T
L
Y
K
L
S
A
-
K
G
Y
I
T
A
M
G
G
V
I
S
T
G
K
E
A
N
V
F
Y
A
D
G
V
F
--
D
G
K
P
V
--
A
M
A
V
--
K
I
Y
R
I
E
T
S
E
F
D
K
-
M
D
E
Y
L
Y
G
D
E
R
F
D
M
-
R
R
I
S
P
K
E
K
V
F
I
W
T
E
K
E
F
R
N
L
E
R
A
K
-
E
A
-
G
V
----
S
-
V
P
-
Q
P
Y
---------
T
----
Y
----
M
-
K
-----
N
V
L
L
M
E
F
I
G
E
D
E
L
P
A
-
P
T
-
L
V
--
E
--------
L
---
G
-
R
E
L
K
E
L
D
V
E
G
I
F
N
D
V
V
E
N
-
V
K
R
L
Y
Q
E
A
E
L
V
H
A
D
L
S
E
Y
N
-
I
M
Y
I
-
D
K
--
V
Y
F
I
D
M
G
Q
A
V
T
L
R
H
P
M
----------
A
-------------
E
S
Y
------
L
-
E
---
R
D
V
R
N
I
I
R
F
F
S
K
Y
G
V
K
A
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
79.01
35%
2
- C3 -
-
4JIN
1
RIO1_ARCFU
A:
[12-258]
----------------------------------------------------------------------------------------------------------------------------------
D
K
L
R
I
K
E
K
D
G
--
E
E
R
K
I
Y
A
E
V
L
D
G
R
T
L
K
T
L
Y
K
L
S
A
-
K
G
Y
I
T
A
M
G
G
V
I
S
T
G
K
E
A
N
V
F
Y
A
D
G
-
V
F
-
D
G
K
P
V
A
M
A
--
V
--
K
I
Y
R
I
E
T
S
E
F
D
K
-
M
D
E
Y
L
Y
G
D
E
R
F
D
M
R
-
R
I
S
P
K
E
K
V
F
I
W
T
E
K
E
F
R
N
L
E
R
A
K
-
E
A
-
G
V
----
S
-
V
P
-
Q
P
Y
---------
T
----
Y
----
M
-
K
-----
N
V
L
L
M
E
F
I
G
E
-
D
E
L
P
A
P
T
-
L
V
--
E
--------
L
GR-
E
L
K
E
L
D
-
V
E
G
--
I
F
N
D
V
V
E
N
-
V
K
R
L
Y
Q
E
A
E
L
V
H
A
D
L
S
E
Y
N
I
M
Y
I
--
D
K
--
V
Y
F
I
D
M
G
Q
A
V
T
L
R
H
P
M
----------
A
-------------
E
S
Y
------
L
-
E
---
R
D
V
R
N
I
I
R
F
F
S
K
Y
G
V
K
--
A
D
F
E
E
M
L
K
E
V
K
G
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
77.42
37%
-12
- C3 -
-
3RE4
1
RIO1_ARCFU
A:
[3-248]
-------------------------------------------------------------------------------------------------------------------------
D
L
K
K
I
E
S
Y
L
D
K
L
R
I
K
E
K
D
G
--
E
E
R
K
I
Y
A
E
V
L
D
G
R
T
L
K
T
L
Y
K
L
S
A
-
K
G
Y
I
T
A
M
G
G
V
I
S
T
G
K
E
A
N
V
F
Y
A
D
G
V
F
--
D
G
K
P
V
--
A
--
M
A
V
K
I
Y
R
I
E
----
D
K
-
M
D
E
Y
L
Y
G
D
E
R
F
D
M
-
R
R
I
S
P
K
E
K
V
F
I
W
T
E
K
E
F
R
N
L
E
R
A
K
-
E
A
-
G
V
----
S
-
V
P
-
Q
P
Y
---------
T
----
Y
----
M
-
K
-----
N
V
L
L
M
E
F
I
G
E
D
E
L
P
A
-
P
T
-
L
V
--
E
--------
L
---
G
-
R
E
L
K
E
L
D
V
E
G
I
F
N
D
V
V
E
N
-
V
K
R
L
Y
Q
E
A
E
L
V
H
A
D
L
S
E
Y
N
-
I
M
Y
I
-
D
K
--
V
Y
F
I
D
M
G
Q
A
V
T
L
R
H
P
M
----------
A
-------------
E
S
Y
------
L
-
E
---
R
D
V
R
N
I
I
R
F
F
S
K
Y
G
V
K
A
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
77.15
35%
-5
- C3 -
-
1ZTH
1
RIO1_ARCFU
D:
[12-257]
----------------------------------------------------------------------------------------------------------------------------------
D
K
L
R
I
K
E
K
D
G
--
E
E
R
K
I
Y
A
E
V
L
D
G
R
T
L
K
T
L
Y
K
L
S
A
-
K
G
Y
I
T
A
M
G
G
V
I
S
T
G
K
E
A
N
V
F
Y
A
D
G
-
V
F
-
D
G
K
P
V
A
M
A
--
V
--
K
I
Y
R
I
--------
M
D
E
Y
L
Y
G
D
E
R
F
D
-------
K
E
K
V
F
I
W
T
E
K
E
F
R
N
L
E
R
A
K
-
E
A
-
G
V
----
S
-
V
P
-
Q
P
Y
---------
T
----
Y
----
M
-
K
-----
N
V
L
L
M
E
F
I
G
E
-
D
E
L
P
A
P
T
-
L
V
--
E
--------
L
G
R
-
E
L
K
E
L
D
-
V
E
G
--
I
F
N
D
V
V
E
N
-
V
K
R
L
Y
Q
E
A
E
L
V
H
A
D
L
S
E
Y
N
I
M
Y
I
--
D
K
--
V
Y
F
I
D
M
G
Q
A
V
T
L
R
H
P
M
----------
A
-------------
E
S
Y
------
L
-
E
---
R
D
V
R
N
I
I
R
F
F
S
K
Y
G
V
K
--
A
D
F
E
E
M
L
K
E
V
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
65.20
26%
-135
- C3 -
-
1ZAR
3
RIO2_ARCFU
A:
[75-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
L
S
L
Y
S
L
H
R
L
V
R
-
S
G
K
V
D
A
I
G
K
L
M
G
E
G
K
E
S
A
V
F
N
C
Y
S
-
E
--
K
F
G
E
C
--
V
--
V
--
K
F
H
K
V
------
K
-
V
K
-------
E
-------
H
F
S
V
L
A
I
R
S
A
R
N
E
F
R
A
L
Q
K
L
Q
-
G
---
L
----
A
-
V
P
-
K
V
Y
---------
A
----
W
----
E
-
G
-----
N
A
V
L
M
E
L
I
D
--
A
K
E
L
-
Y
R
-
V
R
--
V
----------------
E
N
-
P
D
E
--
V
L
D
M
I
L
E
E
-
V
A
K
F
-
Y
H
R
G
I
V
H
G
D
L
S
Q
Y
N
V
L
V
S
E
-
E
G
--
I
W
I
I
D
F
P
Q
S
V
E
V
G
E
E
G
----------
W
-------------
R
E
I
------
L
-
E
---
R
D
V
R
N
I
I
T
Y
F
S
R
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
63.73
26%
-135
- C3 -
-
1ZAO
2
RIO2_ARCFU
A:
[75-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
L
S
L
Y
S
L
H
R
L
V
R
-
S
G
K
V
D
A
I
G
K
L
M
G
E
G
K
E
S
A
V
F
N
C
Y
S
-
E
--
K
F
G
E
C
--
V
--
V
--
K
F
H
K
V
G
H
T
---
K
-
V
K
-------
E
--------
F
S
V
L
A
I
R
S
A
R
N
E
F
R
A
L
Q
K
L
Q
-
G
---
L
----
A
-
V
P
-
K
V
Y
---------
A
----
W
----
E
-
G
-----
N
A
V
L
M
E
L
I
D
--
A
K
E
L
-
Y
R
-
V
R
--
V
----------------
E
N
-
P
D
E
--
V
L
D
M
I
L
E
E
-
V
A
K
F
-
Y
H
R
G
I
V
H
G
D
L
S
Q
Y
N
V
L
V
S
E
-
E
G
--
I
W
I
I
D
F
P
Q
S
V
E
V
G
E
E
G
----------
W
-------------
R
E
I
------
L
-
E
---
R
D
V
R
N
I
I
T
Y
F
S
R
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
60.14
20%
8
- C3 -
-
1TQM
1
RIO2_ARCFU
A:
[1-282]
------------------------------------------------------------------------------
M
N
I
A
E
L
Y
G
K
M
G
K
H
S
W
R
I
M
D
A
I
F
K
N
L
W
D
Y
E
Y
V
P
L
Q
L
I
S
S
H
A
RI
G
E
E
K
A
R
N
I
L
K
Y
L
S
D
L
R
V
V
Q
N
R
Q
K
D
Y
E
G
S
T
F
T
F
I
G
L
S
L
Y
S
L
H
R
L
V
R
-
S
G
K
V
D
A
I
G
K
L
M
G
E
G
K
E
S
A
V
F
N
C
Y
S
-
E
--
K
F
G
E
C
--
V
--
V
--
K
F
H
K
V
K
V
---------------------
K
E
H
F
S
V
L
A
I
R
S
A
R
N
E
F
R
A
L
Q
K
L
Q
----
G
L
----
A
-
V
P
-
K
V
Y
---------
A
----
W
----
E
-
G
-----
N
A
V
L
M
E
L
I
D
A
K
E
L
Y
R
-
V
R
-
V
E
--
N
-------------------
P
D
E
--
V
L
D
M
I
L
E
E
-
V
A
K
F
Y
H
R
-
G
I
V
H
G
D
L
S
Q
Y
N
V
L
V
S
E
-
E
G
--
I
W
I
I
D
F
P
Q
S
V
E
V
G
E
E
G
----------
W
-------------
R
E
I
------
L
-
E
---
R
D
V
R
N
I
I
T
Y
F
S
R
T
Y
R
T
E
K
-
D
I
N
S
A
I
D
R
I
L
Q
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
58.80
26%
-78
- C3 -
-
1TQP
1
RIO2_ARCFU
A:
[82-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
R
L
V
R
-
S
G
K
V
D
A
I
G
K
L
M
G
E
G
K
E
S
A
V
F
N
C
Y
S
-
E
--
K
F
G
E
C
--
V
--
V
--
K
F
H
K
V
------
K
V
K
E
-------
H
F
S
V
L
A
I
R
S
A
R
N
--------
E
F
R
A
L
Q
K
L
Q
----
G
L
----
A
-
V
P
-
K
V
Y
---------
A
----
W
----
E
-
G
-----
N
A
V
L
M
E
L
I
D
A
----------
K
--
E
--------
L
---
Y
R
V
R
V
E
N
P
D
E
--
V
L
D
M
I
L
E
E
-
V
A
K
F
Y
H
R
G
-
I
V
H
G
D
L
S
Q
Y
N
V
L
V
S
E
-
E
G
--
I
W
I
I
D
F
P
Q
S
V
E
V
G
E
E
G
----------
W
-------------
R
E
I
------
L
-
E
---
R
D
V
R
N
I
I
T
Y
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
58.18
27%
-43
- C3 -
-
1TQM
1
RIO2_ARCFU
A:
[82-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
R
L
V
R
-
S
G
K
V
D
A
I
G
K
L
M
G
E
G
K
E
S
A
V
F
N
C
Y
S
-
E
--
K
F
G
E
C
--
V
--
V
--
K
F
H
K
V
------
K
V
K
E
-------
H
F
S
V
L
A
I
R
S
A
R
N
--------
E
F
R
A
L
Q
K
L
Q
----
G
L
----
A
-
V
P
-
K
V
Y
---------
A
----
W
----
E
-
G
-----
N
A
V
L
M
E
L
I
-----
D
A
-
K
E
-
L
Y
--
R
--------
V
---
R
V
E
N
P
D
E
V
------
L
D
M
I
L
E
E
V
A
K
F
Y
H
R
G
-
I
V
H
G
D
L
S
Q
Y
N
V
L
V
S
E
-
E
G
--
I
W
I
I
D
F
P
Q
S
V
E
V
G
E
E
G
----------
W
-------------
R
E
I
------
L
-
E
---
R
D
V
R
N
I
I
T
Y
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
58.01
27%
-41
- C3 -
-
1TQI
2
RIO2_ARCFU
A:
[82-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
R
L
V
R
-
S
G
K
V
D
A
I
G
K
L
M
G
E
G
K
E
S
A
V
F
N
C
Y
S
-
E
--
K
F
G
E
C
--
V
--
V
--
K
F
H
K
V
------
K
V
K
E
-------
H
F
S
V
L
A
I
R
S
A
R
N
--------
E
F
R
A
L
Q
K
L
Q
----
G
L
----
A
-
V
P
-
K
V
Y
---------
A
----
W
----
E
-
G
-----
N
A
V
L
M
E
L
I
-----
D
A
-
K
E
-
L
Y
--
R
--------
V
---
R
V
E
N
P
D
E
V
------
L
D
M
I
L
E
E
V
A
K
F
Y
H
R
G
-
I
V
H
G
D
L
S
Q
Y
N
V
L
V
S
E
-
E
G
--
I
W
I
I
D
F
P
Q
S
V
E
V
G
E
E
G
----------
W
-------------
R
E
I
------
L
-
E
---
R
D
V
R
N
I
I
T
Y
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
57.07
27%
-38
- C3 -
-
1ZAR
3
RIO2_ARCFU
A:
[82-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
R
L
V
R
-
S
G
K
V
D
A
I
G
K
L
M
G
E
G
K
E
S
A
V
F
N
C
Y
S
-
E
--
K
F
G
E
C
--
V
--
V
--
K
F
H
K
V
------
K
V
K
E
-------
H
F
S
V
L
A
I
R
S
A
R
N
--------
E
F
R
A
L
Q
K
L
Q
----
G
L
----
A
-
V
P
-
K
V
Y
---------
A
----
W
----
E
-
G
-----
N
A
V
L
M
E
L
I
-----
D
A
-
K
E
-
L
Y
--
R
--------
V
---
R
V
E
N
P
D
E
V
------
L
D
M
I
L
E
E
V
A
K
F
Y
H
R
G
-
I
V
H
G
D
L
S
Q
Y
N
V
L
V
S
E
-
E
G
--
I
W
I
I
D
F
P
Q
S
V
E
V
G
E
E
G
----------
W
-------------
R
E
I
------
L
-
E
---
R
D
V
R
N
I
I
T
Y
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
57.02
27%
-43
- C3 -
-
1ZAO
2
RIO2_ARCFU
A:
[82-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
R
L
V
R
-
S
G
K
V
D
A
I
G
K
L
M
G
E
G
K
E
S
A
V
F
N
C
Y
S
-
E
--
K
F
G
E
C
--
V
--
V
--
K
F
H
K
V
G
H
T
---
K
V
K
E
--------
F
S
V
L
A
I
R
S
A
R
N
--------
E
F
R
A
L
Q
K
L
Q
----
G
L
----
A
-
V
P
-
K
V
Y
---------
A
----
W
----
E
-
G
-----
N
A
V
L
M
E
L
I
-----
D
A
-
K
E
-
L
Y
--
R
--------
V
---
R
V
E
N
P
D
E
V
------
L
D
M
I
L
E
E
V
A
K
F
Y
H
R
G
-
I
V
H
G
D
L
S
Q
Y
N
V
L
V
S
E
-
E
G
--
I
W
I
I
D
F
P
Q
S
V
E
V
G
E
E
G
----------
W
-------------
R
E
I
------
L
-
E
---
R
D
V
R
N
I
I
T
Y
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
47.94
20%
-38
- C3 -
-
4AZF
1
DYRK2_HUMAN
A:
[99-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K-
V
H
Q
H
V
--
A
--
L
--
K
M
V
R
N
E
K
R
F
H
R
---------------------------
Q
A
A
E
E
I
R
I
L
E
H
L
R
-
K
Q
D
K
D
NTM-
N
-
V
I
-
H
M
L
---------
E
N
F
T
F
R
----
N
-
H
-----
I
C
M
T
F
E
L
L
S
--
M
N
L
Y
-
E
L
-
I
K
--
K
--------
N
KFQ
G
F
S
L
P
L
-
V
R
K
--
F
A
H
S
I
L
Q
C
-
L
D
A
L
-
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
YTYIQSRFYR
A
-------------
P
E
V
------
I
L
G
---
A
R
Y
G
M
P
I
D
M
W
S
-
L
G
C
I
-------
L
A
E
L
L
T
G
Y
P
L
L
P
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
47.60
20%
-26
- C3 -
-
4Y0X
1
PKNG_MYCTU
A:
[121-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
K
G
C
I
A
H
G
G
L
G
W
I
Y
L
A
L
D
-
R
NV
N
G
R
P
V
--
V
--
L
--
K
G
L
V
H
S
G
D
A
E
-------------------------
A
Q
A
M
A
M
A
E
R
Q
F
L
A
E
V
V
-
H
P
-
S
I
----
V
Q
I
F
-
N
F
V
---------
E
----
H
----
T
D
R
HG
D
P
V
G
Y
I
V
M
E
Y
V
G
--
G
Q
S
L
-
K
R
-
S
K
--
G
--------
Q
---
K
L
P
V
A
E
-
A
I
A
--
Y
L
L
E
I
L
P
A
-
L
S
Y
L
-
H
S
I
G
L
V
Y
N
D
L
K
P
E
N
I
M
L
T
E
-
E
Q
--
L
K
L
I
D
L
G
A
V
S
R
I
N
S
F
G
YLYGTPGFQ-
A
-------------
P
E
I
------
V
-
R
---
T
G
P
T
V
A
T
D
I
Y
T
-
V
G
R
T
-------
L
A
A
L
T
L
D
L
P
T
R
N
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
45.56
19%
-22
- C3 -
-
1V0B
-
CDC2H_PLAFK
A:
[4-203]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
--
Y
G
E
T
F
--
A
--
L
--
K
K
I
R
L
E
K
E
D
E
G
------------------------
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
-
H
S
-
N
I
----
V
-
K
L
Y
D
V
I
---------
H
T
---
K
----
K
-
R
-----
L
V
L
V
F
E
H
L
D
--
Q
D
L
K
-
K
L
-
L
D
V
C
E
--------
G
---
G
L
E
S
V
T
-
A
K
S
--
F
L
L
Q
L
L
N
G
-
I
A
Y
C
-
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
E
G
E
--
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
----------
R
K
Y
T
H
E
V
V
T
L
W
Y
RA
P
D
V
------
L
-
M
GS-
K
K
Y
S
T
T
I
D
I
W
S
-
V
G
C
I
-------
F
A
E
M
V
N
G
A
P
L
F
P
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
44.30
14%
-44
- C3 -
-
5EH0
2
A:
[6-200]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
-
E
--
K
K
Q
I
Y
--
A
--
I
--
K
Y
V
N
L
E
E
A
D
N
Q
------------------------
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
-
Q
H
-
S
D
----
K
-
I
I
-
R
L
Y
---------
D
----
Y
E
I
T
D
Q
-
Y
-----
I
Y
M
V
M
E
C
G
N
--
I
D
L
N
-
S
W
-
L
K
--
K
--------
K
K--
S
I
D
P
W
E
-
R
K
S
--
Y
W
K
N
M
L
E
A
-
V
H
T
I
-
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
-
G
M
--
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
G
----------
T
-------------
V
N
Y
MP
P
E
A
I
K
-
D
---
M
K
I
S
P
K
S
D
V
W
S
-
L
G
C
I
-------
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
44.01
15%
-36
- C3 -
-
4LV5
6
?
A:
[35-295]
-------------------------------------------------------------------------------------------------------------------------------------------
A
--
M
V
E
A
V
T
A
T
V
W
P
Q
N
A
E
T
T
V
D
S
L
L
S
Q
G
E
R
K
L
K
L
V
E
P
L
R
V
G
D
R
S
V
V
F
L
V
R
D
-
V
E-
R
L
E
D
F
--
A
--
L
--
K
V
F
T
M
G
A
E
N
S
R
S
E
L
E
R
L
H
E
A
T
F
A
A
A
-----------------------
R
L
L
-
L
P
S
D
A
V
A
V
Q
S
-
Q
P
-
P
F
A
QLSPGQDD
Y
A
----
V
----
A
-
N
-----
Y
L
L
L
M
P
A
A
S
--
V
D
L
E
-
L
L
-
F
S
--
T
L
D
F
VYVFR
G
---
D
E
G
I
L
A
-
L
H
I
--
L
T
A
Q
L
I
R
L
-
A
A
N
L
-
Q
S
K
G
L
V
H
G
H
F
T
P
D
N
L
F
I
M
P
D
G
R
--
L
M
L
G
D
V
S
A
L
W
K
V
G
T
R
G
----------
P
ASSVP--------
V
T
Y
AP
R
E
F
-
L
-
N
A
S
T
A
T
F
T
H
A
L
N
A
W
Q
-
L
G
L
S
-------
I
Y
R
V
W
C
L
F
L
P
F
G
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
42.98
16%
-60
- C3 -
-
2Y7J
1
PHKG2_HUMAN
C:
[96-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
-
R
A-
T
G
H
E
F
--
A
--
V
--
K
I
M
E
V
T
A
E
R
L
S
P
------------------
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
-
H
I
-------
I
-
T
L
I
---------
D
SYES
S
----
S
-
F
-----
M
F
L
V
F
D
L
M
R
--
K
G
E
L
-
F
D
Y
L
T
--
E
K-------
V
---
A
L
S
E
K
E
-
T
R
S
--
I
M
R
S
L
L
E
A
-
V
S
F
L
-
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
M
Q
--
I
R
L
S
D
F
G
F
S
C
H
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
42.90
15%
-31
- C3 -
-
2Y7J
1
PHKG2_HUMAN
D:
[96-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
-
R
A-
T
G
H
E
F
--
A
--
V
--
K
I
M
E
V
---
R
L
S
P
------------------
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
-
H
I
----
I
-
T
L
-
I
D
S
---------
Y
ES--
S
----
S
-
F
-----
M
F
L
V
F
D
L
M
R
--
K
G
E
L
-
F
D
Y
L
T
--
E
K-------
V
---
A
L
S
E
K
E
-
T
R
S
--
I
M
R
S
L
L
E
A
-
V
S
F
L
-
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
M
Q
--
I
R
L
S
D
F
G
F
S
C
H
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------