@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_29_0380: (2018-03-11 )
MGDSQHSSVHSRYGGGQSSIDVSSLMTVNVAGLRNSGVLSPLVWQTPRPTSSASLTMLGLNRRDVLSTSSLAPWSMTPKAGHQRQQGRGLEHGSVPTPTQSSSSSSQANDAATTAGSPFFAGAASLVASAEWAALITKLGDFYDFVVRLPGFHTDDRTAFSAMSSRGVDGDAEHKSYHSSELPRSPEPPGTLPPSLQQSRDPQRREVLFPDPAEAARQRKTVRSPKSCDASVTHEIVSASAVSVSSEASRRRNNNAGSLERNGKDEESEEDRPSTAPAAGPRRLNSTSRCLSQAPDAEAPPGVTTAFDRYLEQARHMILCADSSEVDRAVALDGLLMRCRELFDLLRDMYTLAHVPGATADRSHLSMVKVLPYDEVSTPSSTSVSSTSSIPPGPALRTQESNSDTKGVPLSSTTQPWNSQLPPLSWRPLTAATAARSKDAFERGRRTSVSSCSSSVACIEVLNNYYVMQLIGVGATGRVYLAVDRHTCKAFAMKTVPRHSRRAVGRRFPLAPMSASDSEALQLEGSMLRAVHIDGAAAHAAGSSTTTNAPLALVRPFSMSVASVRPATRREGTRDSMDVSLCEAALDSLIHVAATSHPSDAAIPFVESVTASSSAMTPGSGDVEAPNTSKKPPPQTSSSKHLNGSSLQICAGGAGLHTTVSRSTNAGESVGGDSVVKSVKSAHSSELPAVEREIRVMRRVCNHPHVAQLKEVIDDDKEDSVHLVMTYAENGPLTVMHGFDAALGCAPCDVVRPFSRCARLLHQLAEALIYVHRQRIVHNDVKPDNILLTEADNILLTDFGESVLISKKLPQMPAAHMSIGAAGGEGLNASVLVPHNRWKSSRGANDSWATLSTADRSPCSSSPAGHTANTSQMMAETSFLPDSSMFLAAGVDVEGRLKGNRSAIGTPAFAAPELIMSSTCSYDSDAWSFGVVLYSVIFGRLPFAAATISETFSEILNSALSFPALEEVPERVGMTETDYHQWVELCTKLLVREPRQRLPLSAVLRHPLFRTPAAVGAKPSTSATGGVEMPRGRRPPSRIHSDLSSAPTLWWPNHSSQASRPVSDKEGSPLMSRAARAAMPPLMSREGAASVSAAANRRCSTEGSKSPLTRGGAVREAVLDRHRLQTMAGSSQASSIFASSGTSMASLSPPAASAGFGRRSKPTVAEAAAPQMWPEIRPLQAARLQCQCAWPNSSPAGRHSFSGASSVHTASFTATGHMGRPREHTLVYKQGFASQSASAIQSPINRSFFSTSTPFKESPPDRVVTPGIQLTSCTDFTSPLPCLLTRAGSSTPDLGTEDHEEDQQDESGKEESRSSNVAGAVIALAAVAAPAPPASPPATSSAGRPRSVAAARGAREDTAAVGPCVQRRCSEEEPCEGDGSSGAGCNFSYWGSSNDVADSGDSEDERRKQEINDKASQLPKPPLRPPSGRSAHSSSAVRPLASLQEVVAQHVKPKGRGEHLKSVAGVPYGDSTIAPGSPDNLSATRELVQKARETESPVQQRASKSSPLSNNLVVNSTACGGSSSPCPSPLKSTSEIPPAQAKKSRFWCHR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590......--.600.......610.......620.......630.......640..-----.....650.......660.......670......--------.680.--------.------.....690.......700.......710.....----..720.......730........740.......750.......760.......770.......780......----.---790.---.----.--......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910....------..-----.-------920.......930......-.940.......--950.......960--.....------------..970----.........980.......990.....--...1000--.........1010......1020......1030....----..1040......1050......1060.....---------.1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGDS
Q
H
S
S
V
H
SRYGGGQS
S
I
D
V
S
S
L
M
T
V
N
V
AGLRNSGVLS
P
L
VWQTPRPTSSA
S
L
T
M
L
GLNRRDVLSTSSLAPWSMTPKAGH
Q
R
QQGRGLEHGSVPTPTQSSSSSSQANDAATTAGS
P
F
F
A
G
A
A
S
L
V
A
S
A
E
W
A
A
L
I
T
K
L
G
D
F
Y
D
F
V
V
RLPGFHTD
D
R
T
A
F
S
A
M
SSRGVDGDAEHKSYHSSELPRSPEPPGTLPPS
L
Q
QSRDPQRREVLFPD
P
A
E
A
A
R
Q
R
K
TVRSPKSC
D
A
S
V
T
H
E
I
V
SASAVSV
S
S
E
A
S
RRRNNNAGSLERNGKDEESEEDRPSTAPAAGPRRL
N
S
T
S
R
C
L
SQAPDAEAPPG
V
T
T
A
F
D
R
Y
L
E
QAR
H
M
I
L
CA
D
S
S
EV
D
R
A
V
A
L
D
G
L
L
M
R
C
R
E
L
F
D
L
L
R
D
M
Y
T
L
AHVPGATADRSH
L
S
M
V
K
VLPYDEVSTPSSTSVSSTSSIPPGPALRTQESNSDTKGVPLSSTTQPWNSQLPPLSWRPL
T
A
A
TAAR
S
K
D
A
F
E
RGRRT
S
V
S
S
CSS
S
V
A
C
I
E
V
L
N
N
Y
Y
V
M
Q
L
I
GVGAT
G
R
V
Y
L
A
V
DRH
T
C
K
A
F
A
M
KTVP
R
H
S
R
R
A
VGRRFPLAPMSASDS
E
A
L
Q
LEG
S
M
L
R
A
V
H
IDGAAAHAAGSSTTTNA
P
L
A
L
V
RPFSMSVASVRPATRREGTRDS
M
D
V
S
L
C
E
A
A
L
D
S
L
I
H
V
AATSHP--SDAA
I
P
F
V
E
S
VTASSSAMTPGSGDVEAPNTSKKPPPQTSSSKHLNG-----S
S
L
Q
I
C
AGGAG
L
H
T
T
VSRSTNAGESVG
G
D
S
V
V
K
S
--------
V
K
S
AH--------S------SEL
P
A
V
E
R
E
I
R
V
M
R
R
VCNHP
H
V
A
Q
L
K
E
V
IDDDK----ED
S
V
H
L
V
M
T
YAENG-
P
L
T
V
M
HGFDAALGCA
P
C
D
V
V
R
P
F
S
R
C
A
R
L
L
H
Q
L
A
E
A
L
I
Y
V
H
R
Q
R
I
V
HNDVKPD
N
I
L
L
----T---E--A---D----
N
--
I
L
L
TDFGE
S
V
LISKKLPQMPA
A
H
M
S
IGAAGGEGL
N
A
S
V
L
V
PHNRWKSSRGANDSWATLSTADRSPCSSSPAGHTA
N
T
S
Q
M
M
A
ETSFLPDS
S
M
F
L
A
AGV
D
V
E
G
R
LKGNRSAIGTPAFA
A
P
E
L
I
M
------
S
S-----T-------CSYDSD
A
W
S
F
G
V
V
L
Y
S
V
I
F-GRLP
F
A
A
A
T
I
S
--
E
T
F
S
E
I
L
N
S
ALS
F
--
P
A
L
E
E
------------
V
P
E
------RVGMT
E
T
D
Y
H
Q
W
V
E
L
C
T
K
L
L
V-RE
P
R
Q
--RL
P
L
-----
S
A
V
L
RHPLFRTPAAVGAKPSTSATGGVEMPRGRR
P
P
S
----
R
I
H
S
D
L
SSA
P
T
L
WWPNHSSQASRPVSDKEG
S
---------
P
L
M
S
R
A
A
R
AAMPPLMSREGAA
S
V
S
A
A
ANRRCSTEGSKSPLTRG
G
A
V
R
E
A
V
L
D
R
H
R
L
Q
T
MAGSS
Q
A
S
S
I
FASSGTSMASLSPPAASAGFGRRSKPTVAEAAAPQMWPEIRPLQ
A
A
R
L
Q
C
Q
C
AWPNSSPAGRHSFSGAS
S
V
H
T
A
S
F
T
ATGHMGRPRE
H
T
L
V
Y
KQGFASQ
S
A
S
A
I
Q
S
P
I
N
RSFFSTSTPFKESPPDRVVTPG
I
Q
L
T
SCTDFTS
P
L
P
C
L
L
TRAGSSTPDLGTEDHEEDQQDESGKEESRSSN
V
A
G
A
V
I
A
L
A
A
VAAPAPPASPPATSSAGRPR
S
V
A
AARGAREDTAAV
G
P
C
V
Q
R
RCSEEEPCEGDGSSGAGC
N
F
S
YWGSSNDVADSGD
S
E
D
E
R
R
K
Q
E
I
N
D
K
A
SQLPKPPLRPPSGRSAHSSSAV
R
P
L
A
S
L
Q
E
V
V
A
Q
HVKPKGR
G
E
H
L
K
S
V
AGVPYGDSTIAPGSPD
N
L
S
A
T
R
E
L
V
Q
K
A
RETE
S
P
V
Q
Q
R
ASKSSPLSN
N
L
V
V
N
STACGGSSSPCPSPLKSTSEIPPAQAKKSRFWCHR
31
HHSearch
68.02
26%
-113
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[98-352]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
--
S
G
K
L
V
A
V
K
K
--------
M
D
L
R
K
--------
Q
------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
-
A
L
T
D
I
-----
V
T
H
-----
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
----
T
---
H
--
D
---
G
----
R
--
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
----------------------------------------------------------------------------------------
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
------
R
L
-----
P
-------
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
-
G
E
P
P
Y
F
N
E
P
P
L
--
K
A
M
K
M
I
R
D
N
---
L
--
P
P
R
--------------
L
K
----------
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
-
R
D
P
A
Q
--
R
A
T
A
-----
A
E
L
L
K
H
P
F
L
A
K
A
G
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
65.98
19%
-16
- C1 -
-
1KOB
1
?
A:
[23-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
-----
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
-----
G
R
V
F
V
A
K
F
--------
I
N
T
P
Y
--------
P
------
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
E
D
------
K
Y
E
M
V
L
I
L
E
F
---------
L
S
G
G
E
L
F
D
R
I
A
A
E
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
----
E
---
T
--
K
---
K
AS--
S
--
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
-----------------------------------------------------------------------------------------
E
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
E
-----
P
-------
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
-
G
L
S
P
F
A
G
E
D
D
L
--
E
T
L
Q
N
V
K
R
C
D
W
E
F
--
D
--
E
D
------------
A
F
S
------
S
V
S
------
P
E
A
K
D
F
I
K
N
L
L
Q
-
K
E
P
R
K
--
R
L
T
V
-----
H
D
A
L
E
H
P
W
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
----
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
---------
Y
F
D
R
K
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
64.18
27%
-180
- C1 -
-
4JXF
2
PLK4_HUMAN
A:
[54-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
N
E
V
K
I
H
C
Q
L
-
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
------
N
Y
V
Y
L
V
L
E
M
C
H
N
G
-
E
M
N
R
Y
-----
L
K
N
R
---
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
----
T
---
R
--
N
---
M
----
N
--
I
K
I
A
D
F
G
L
A
T
Q
L
K
M
P
H
E
-----------------------------------------------------------------------------------------------------------------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
-
G
R
P
P
F
----
V
K
--
N
T
L
N
K
V
V
L
A
D
Y
E
M
--------------------------------
P
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
-
R
N
P
A
D
--
R
L
S
L
-----
S
S
V
L
D
H
P
F
M
S
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
64.06
24%
-51
- C1 -
-
1KOB
1
?
A:
[49-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
D
-----
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
--
T
G
R
V
F
V
A
K
F
--------
I
N
T
P
Y
--------
P
------
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
------
Y
E
M
V
L
I
L
E
F
L
S
G
G
-
E
L
F
-----
D
R
I
A
A
E
---
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
----
E
---
T
--
K
KA-
S
----
S
--
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
--------------------------------------------------------------------------------------
I
---
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
E
-----
P
-------
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
-
G
L
S
P
F
A
G
E
D
D
L
--
E
T
L
Q
N
V
K
R
C
D
W
E
F
--
D
E
--
D
------------
A
------------
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
-
K
E
P
R
K
--
R
L
T
V
-----
H
D
A
L
E
H
P
W
L
K
G
D
H
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
61.75
27%
2
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[90-365]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
Y
Q
-----
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
--
T
G
H
E
F
A
V
K
I
--------
M
E
V
--RLSPEQL-
E
------
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
------
S
F
M
F
L
V
F
D
L
M
R
K
G
-
E
L
F
-----
D
Y
L
T
E
K
----
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
---
D
--
N
---
M
----
Q
--
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
-----------------------------------------------------------------------------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
-----
G
-------
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
H
R
R
Q
I
--
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
--
S
S
P
-
E
-------------------------
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
-
V
D
P
E
A
--
R
L
T
A
-----
E
Q
A
L
Q
H
P
F
F
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
61.68
30%
-83
- C1 -
-
5JZN
1
DCLK1_HUMAN
A:
[64-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
N
E
V
S
I
L
R
R
V
-
K
H
P
N
I
V
L
L
I
E
E
M
D
V
P
------
T
E
L
Y
L
V
M
E
L
V
K
G
G
-
D
L
F
-----
D
A
I
T
S
T
----
N
K
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
D
---
G
--
S
---
K
----
S
--
L
K
L
G
D
F
G
L
A
T
I
V
D
G
P
-------------------------------------------------------------------------------------------
L
Y
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
A
------
E
T
-----
G
-------
Y
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
-
G
F
P
P
F
R
G
S
--
D
Q
E
V
L
F
D
Q
I
L
M
G
Q
V
D
F
--
P
S
P
--------------------------
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
-
V
D
V
D
Q
--
R
F
S
A
-----
V
Q
V
L
E
H
P
W
V
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
61.06
24%
9
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
G
P
A
Q
T
N
G
Q
CF
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
HREDF
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
N
A
D
K
V
F
A
M
-
K
I
L
N
K
--------
W
E
M
L
K
--------
R
------
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
------
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
R
L
---------
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
----
D
---
M
--
N
---
G
----
H
--
I
R
L
A
D
F
G
S
---------------------------
C
L
K
L
M
E
D
G
T
V
Q
S
S
V
------------------------------------------------------------
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
------
A
M
E
GGKG
R
-------
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
-
G
E
T
P
F
Y
A
E
S
L
V
--
E
T
Y
G
K
I
M
N
H
K
E
R
F
--
Q
F
P
T
Q
------------
V
T
D
------
V
-------
S
E
N
A
K
D
L
I
R
R
L
I
C
S
R
E
H
R
L
G-
Q
N
G
I
-----
E
D
F
K
K
H
P
F
F
S
G
I
D
W
D
N
I
R
N
C
E
A
P
Y
----
I
P
E
V
S
S
P
T
D
----
T
S
N
F
D
V
D
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
---------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
60.87
27%
4
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[89-365]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
F
Y
Q
-----
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
--
T
G
H
E
F
A
V
K
I
--------
M
E
V
T
A
ERLSPEQL
E
------
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
------
S
F
M
F
L
V
F
D
L
M
R
K
G
-
E
L
F
-----
D
Y
L
T
E
K
----
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
---
D
--
N
---
M
----
Q
--
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
-----------------------------------------------------------------------------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
-----
G
-------
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
H
R
R
Q
I
--
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
--
S
S
P
-
E
-------------------------
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
-
V
D
P
E
A
--
R
L
T
A
-----
E
Q
A
L
Q
H
P
F
F
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
59.41
22%
-65
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[19-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Y
E
-----
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
--
S
K
K
T
Y
M
A
K
F
--------
V
K
V
K
G
---------------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
------
E
E
L
V
M
I
F
E
F
I
S
G
L
-
D
I
F
-----
E
R
I
N
T
S
---
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
----
Q
---
T
RR
S
---
S
----
T
--
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
-----------------------------------------------------------------------------------------
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
-----
V
-------
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
L
A
E
T
N
Q
--
Q
I
I
E
N
I
M
N
A
E
Y
T
F
--
D
E
E
--------------
A
------------
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
-
K
E
R
K
S
--
R
M
T
A
-----
S
E
A
L
Q
H
P
W
L
K
Q
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
58.61
24%
-18
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[22-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
-----
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
--
T
G
Q
Q
F
A
V
K
I
--------
V
D
V
A
K
F
T
S
SP---
G
------
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
------
G
M
L
Y
M
V
F
E
F
M
D
G
A
-
D
L
C
F
E
-----
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
----
A
---
S
--
K
ENS
A
----
P
--
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
--------------
L
--------------------------------------------------------------------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
-----
P
-------
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
C
L
P
F
Y
G
T
K
E
---
R
L
F
E
G
I
I
K
G
K
Y
K
M
--
N
P
R
-
Q
------------
W
-------------
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
-
L
D
P
A
E
--
R
I
T
V
-----
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
58.47
25%
0
- C- -
-
4PDP
-
?
B:
[192-473]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
F
K
D
-----
F
S
I
I
D
E
V
V
G
Q
---
A
T
V
K
K
A
I
E
R
T
--
T
G
K
T
F
S
V
K
I
--------
I
S
K
--------------------
D
G
V
T
R
E
L
E
V
L
Q
K
L
-
N
H
P
R
I
V
R
L
K
G
F
Y
E
D
--------
S
Y
Y
M
V
M
E
F
V
S
G
G
-
D
L
M
D
-----
F
V
A
A
H
----
G
A
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
----
E
---
Q
--
D
---
D
----
P
V
L
V
K
I
T
A
F
G
L
A
K
V
Q
----------------------------------------------------------------------------------------------------
T
L
A
Y
V
A
P
E
V
I
---------N----
E
-------
Y
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
-
G
H
L
P
F
S
G
S
T
Q
D
--
Q
L
Y
K
Q
I
G
R
G
S
Y
H
E
--
G
P
L
K
D
--------------------------
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
-
V
D
P
N
N
--
R
S
T
A
-----
A
K
A
L
N
H
P
W
I
K
M
S
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
58.20
27%
-72
- C1 -
-
5IG1
-
?
A:
[62-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
K
R
E
I
G
I
C
S
S
L
-
Q
H
E
H
I
V
S
M
R
R
A
F
R
D
E
------
S
H
F
Y
L
V
F
E
Y
V
S
G
G
-
E
L
F
-----
D
E
I
V
T
R
----
K
F
Y
N
E
K
D
A
S
A
C
M
H
Q
I
L
S
A
L
Q
H
C
H
S
K
N
I
I
H
R
D
L
K
P
E
N
L
L
L
----
A
SKD
P
--
N
---
A
----
P
--
V
K
I
T
D
F
G
L
A
V
I
M
E
Q
G
P
-----------------------------------------------------------------------------------------
T
Y
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
I
R
------
R
V
-----
P
-------
Y
D
T
A
V
D
V
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
E
E
D
H
Q
--
K
L
Y
A
Q
I
K
N
C
Q
Y
D
F
--
P
S
P
E
--------------------------
W
D
S
V
T
T
A
A
K
E
L
I
K
A
M
L
E
-
P
N
P
K
R
--
R
P
T
V
-----
Q
E
L
L
Q
H
P
W
I
A
R
R
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
57.96
27%
-66
- C1 -
-
5IG1
-
?
B:
[62-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
K
R
E
I
G
I
C
S
S
L
-
Q
H
E
H
I
V
S
M
R
R
A
F
R
D
E
------
S
H
F
Y
L
V
F
E
Y
V
S
G
G
-
E
L
F
-----
D
E
I
V
T
R
----
K
F
Y
N
E
K
D
A
S
A
C
M
H
Q
I
L
S
A
L
Q
H
C
H
S
K
N
I
I
H
R
D
L
K
P
E
N
L
L
L
----
A
SKD
P
--
N
---
A
----
P
--
V
K
I
T
D
F
G
L
A
V
I
M
E
Q
G
P
-----------------------------------------------------------------------------------------
T
Y
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
I
R
------
R
V
-----
P
-------
Y
D
T
A
V
D
V
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
E
E
D
H
Q
--
K
L
Y
A
Q
I
K
N
C
Q
Y
D
F
--
P
S
P
E
--------------------------
W
D
S
V
T
T
A
A
K
E
L
I
K
A
M
L
E
-
P
N
P
K
R
--
R
P
T
V
-----
Q
E
L
L
Q
H
P
W
I
A
R
R
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
57.22
25%
-126
- C1 -
-
2I0E
-
KPCB_HUMAN
A:
[69-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
K
R
V
L
A
L
P
G
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
------
D
R
L
Y
F
V
M
E
Y
V
N
G
G
-
D
L
M
-----
Y
H
I
Q
Q
V
----
G
R
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
K
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
----
D
---
S
--
E
---
G
----
H
--
I
K
I
A
D
F
G
M
C
K
E
N
I
W
D
G
--------------
V
--------------------------------------------------------------------------
T
T
K
T
F
C
G
T
P
D
Y
I
A
P
E
I
I
A
------
Y
Q
-----
P
-------
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
-
G
Q
A
P
F
E
G
E
D
E
D
--
E
L
F
Q
S
I
M
E
H
N
V
A
Y
--
P
K
------------------------------
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
-
K
H
P
G
K
--
R
L
G
C
GP
E
G
E
R
D
I
K
E
H
A
F
F
R
Y
I
D
W
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
56.74
24%
-18
* C1 *
-
3C0I
1
CSKP_HUMAN
A:
[22-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
-----
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
--
T
G
Q
Q
F
A
V
K
I
--------
V
D
V
A
K
F
T
S
SP---
G
------
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
------
G
M
L
Y
M
V
F
E
F
M
D
G
A
-
D
L
C
F
E
-----
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
----
A
---
S
--
K
ENS
A
----
P
--
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
----------------------------------------------------------------------------------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
-----
P
-------
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
C
L
P
F
Y
G
T
K
E
---
R
L
F
E
G
I
I
K
G
K
Y
K
M
--
N
P
R
-
Q
------------
W
-------------
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
-
L
D
P
A
E
--
R
I
T
V
-----
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
56.56
20%
-32
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
-----
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
--
K
K
T
Y
M
A
K
F
--------
V
K
-
V
K
--------
G
------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
------
E
E
L
V
M
I
F
E
F
I
S
---------
G
L
D
I
F
E
R
I
N
T
S
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
----
Q
TR-
R
--
S
---
S
----
T
--
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
-----------------------------------------------------------------------------------------
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
-----
V
-------
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
L
A
E
T
N
Q
--
Q
I
I
E
N
I
M
N
A
E
Y
T
F
--
D
-----------------
E
E
------
A
F
K
E
I
S
I
E
A
M
D
F
V
D
---
R
L
L
V
-
K
E
R
K
S
--
R
M
T
A
-----
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
LNMV
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
56.22
24%
14
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[8-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
-----
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
--
T
G
L
Q
Y
A
A
K
F
--------
I
K
K
R
R
--------
T
KSSRRG
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
-----
F
L
A
E
K
----
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
----
L
---
D
--
R
---
N
VP
K
P
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-----------------------------------------------------------------------------------------
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
-----
P
-------
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
-
G
A
S
P
F
L
G
D
T
K
Q
--
E
T
L
A
N
V
S
A
V
N
Y
E
F
--
E
D
E
--------------------------
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
-
K
D
P
K
K
--
R
M
T
I
-----
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
56.16
24%
-31
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[56-345]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
--
S
G
E
L
V
A
I
K
K
--------
V
L
Q
D
------------------
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
-
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
EKKD
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
-
V
Y
R
V
A
R
H
Y
S
R
------
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
----
D
---
P
D-
T
---
A
----
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
-----------------------------------------------------------------------------------------
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
------
G
A
T----
D
-------
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-
G
Q
P
I
F
P
G
D
S
G
V
--
D
Q
L
V
E
I
I
K
V
L
-
G
T
--
P
T
R
E
Q
I
R
E
M
NPNYTEFK
F
P
Q
IKAHP
W
T
K
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
-
Y
T
P
T
A
--
R
L
T
P
-----
L
E
A
C
A
H
S
F
F
D
E
L
R
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
56.10
29%
-87
- C1 -
-
3V8S
1
ROCK1_HUMAN
D:
[117-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
------
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
-
D
L
V
N
L
-----
M
S
N
-----
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
----
D
---
K
--
S
---
G
----
H
--
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
--------------
M
-------------------------------------------------------------------------
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
------
S
Q
-----
G
GDGY---
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
-
G
D
T
P
F
Y
A
D
S
L
V
--
G
T
Y
S
K
I
M
N
H
K
N
S
L
TF
P
D
D
N
D
------------
I
----------------
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
LG
R
N
G
V
-----
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
52.19
19%
25
- C1 -
-
2RIO
1
IRE1_YEAST
A:
[8-434]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
E
Q
S
L
K
N
L
V
V
S
E
K
I
L
G
Y
G
S
S
G
T
V
V
F
Q
G
S
FQG
R
P
V
A
V
K
R
M
L
--------
I
------
D
F
C
D
I
A
L
M
E
I
K
L
L
T
E
S
D
D
H
P
N
V
I
R
Y
Y
C
S
E
T
T
D
R
------
F
L
Y
I
A
L
E
L
C
N
L
N
----------------
L
Q
D
L
V
E
S
K
Y
N
P
I
S
L
L
R
Q
I
A
S
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
V
----
S
----------------------------------------------------------
T
S
S
R
F
T
A
D
Q
Q
T
G
A
E
N
L
R
I
L
I
S
D
F
G
L
C
K
K
L
D
-----------------------------------------
S
T
S
G
W
R
A
P
E
L
L
E
------
E
S
-----
N
NLQTKRR
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
S
K
G
K
H
P
F
G
D
K
Y
----
S
R
E
S
N
I
I
R
G
I
F
S
L
--
D
E
M
K
C
------------
L
H
D
-----------
R
S
L
I
A
E
A
T
D
L
I
S
Q
M
I
D
-
H
D
P
L
K
--
R
P
T
A
-----
M
K
V
L
R
H
P
L
F
W
P
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
P
S
A
L
----
L
M
K
F
D
A
G
S
D
F
V
I
P
S
G
D
W
T
V
K
F
D
K
T
F
M
D
R
K
Y
H
SSK
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
N
L
S
D
D
Q
I
L
R
E
F
L
Y
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------