@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_29_1550: (2018-03-11 )
MNDIRFPGWIKSSPTLVMASVLAQLLTDECAEATSSATAGAPRPPSEACVPDGRERWPRHNFGEDISSSCSDGGGGVDLSDSDASECEGCYDPDRDAMHSGGGVDTGYLRMVDRLLELNSKELDSLPPAAATAAATTYLPPKAVTAPATAMQTAIAGSWPRGSGVLFTRQNGGVSMSNLGASPDILRNPRVRTLLRLSRLNDVLTRAEAAQPLISRRTAAAMVSFFAFAVSCRYSGLPVDRTKGFFTECSALYTTLLSKLRSLRFGGGVSLEDFTAALVACGLKLRCDEDVEGDEKDGHGGTNEAGVTGAGTAGIPCSGRSNSSSAVASGAAPMGSCGGAGVRTPTQPSFGRDKNYGLVGFGHRALDAIFVRCIPSNIDECVHDPVALGVLRGISLTHSQQLFYLGPELVNHLHDLTDAFATSSHRRELSYKRVLSVLLEAISCSRVIDYERTNNWITAVIQERYVVRGLFQREELHAHVVTATLTMLIRQYQEMAKECASKVVDLGSMPDFTEGDQLIELVWKALQDTIGSWEDAVTTAEKHPLTLFRHNIDMVVQHLLRTEVERLRCYYIITSATAAYHQSLVGMSAGTRTTRNQSGCPPAVPQLAPGREEQRGASQRGRDTLRGQDGNTRRDSDAPAAAPYVPSAEEESLRILICSNIIKLLLLPTSIMNALPRTEEAKQLRASLTEAAARVLSVVTAKEFKSRDDTSVMKAASGRATTSAAPRSISPISAAAAMPRIRRTDAAAAGTDLFVISQRRAHFSNNFYRCIEELIHELIHTILQQSVPDDATAVANRSFLGGVPDVHPPTPPTSDASSDAILRGMVAAVCIQYMCSTNQHLRSFAISEVMDAVVRLSARCGAEEAATATHGSLGRKGSSHTARASGNNSNGSPAAAPQGTVVGAAAADPEEERKHATHLRARQLALCFDALSAILVPTVVVEGYHHVAEEQEERAGLARSCTTTSARGDSKREELSRYGQLLCDTYVDSLREHLWSLGEGSVSRHKLLTPVMTVAVKAFVNLVLRVHERLRGMSSMALALVQEAEAAREGPGKGTRRSAGVIARDRARLLHAFNAERMSVVLLLRGVIQNMLSVAWPSSGVLYQDPACGWERPLNKTTSAVMAPLALAVLSPFFRPLTMLLHLSTLFPVRSLKQLCTHYQYARYLTLEDPSTSDQYMFYYYRRLSRALVAAEADDSGGSGAGPAEQVELECWALFRSCWMMFSYYKYTAEALMAVRAGGMAPMESANPAAAAAALARAPILSTKQCKLLRLIAASAAPLLRMCSSDVQQAMADVAVLLRYTLAGALHCPMVVADVTAKSGIVHASLYKSLKRLCGGRKECWKRLSMGELMLLQCVAELEILRAAAGSVAQLTLYRHFEVREFVASAAIPEALGHILSTACDHYIEAVRSMLPGVAFQVTRTDLMQLVFLVGFAIGSVRESASKLVLCVVRSFPTYAAYASALPLLWCMLDLLEAGTAGQIESLCEHVRFSTVPAVAADPHSVERQQHVLFVADVAERWAAILQDKAPIALFETAIKFMVIQQQECGEQATTQAGRHHAGSRLAVLASLYRVEETPPNLDDSAITVMRGAGAAGHVVKTEYAQTLLLHGRAQGAMQASSWYASAGQMQSTVVAQLWAATRLCRRALASAVAQRLESNLLRPARALFVETGYSVGTVLAPRASTVADEDAAAQEMGVTRVPLGAPARAETAASFAAAVALLVTGSGTPIGRRQLLQYLVQGAVQTFRSDVLYEAILCWKWLLSQNREAYLLPMLQELDTAFVWTAANRLGLFDGYCSSKNRQVQTGDVPIPHNTVSARGQRGARVPEEAAVYVADNVDSASPHKLLLSFLADMYVEEGSPLCLSPEVLRQLYLVAAHIMQFAAVLSLRDDMFGETMRCFLVVGSIAQLLREANVRQLRAGLLTLVPFPAIGALRQRWYKALLRWFTKTPPSWYYAKDPVLAREEAKVLSSLSQLIKEEADLLTRTTLGFLDFSSGVQRERDMPHVHHWESLSVVREAVAAVRQATDGGEAGLPKLIVREKLRLQGLLHLLRVLVEHEVLRLSVWRTPRRTLKIPNTTPSVGWGKLIECADHHNPEVVVAMVYRFSSIPAVRLAASQRVVAHPERYSNVAEAVDLYLTEDVLRAGAPRLFLFCSCTIIQALRLLDPRYAAYKTVNSYAIRSLLSQRSEKLIFYLPQLLQLLATDESGSIEAFLVRTSARSTMFAHQLLWSLQTESEGSGALAKKCQQVERRIKAAFTPNEEAFYRSEFAFVDLMTSLSGEIMKFDKPERKAQLRLRLKDDVFHALPKLRHLYLPTDPNYRITDVIPHTAGAMQSAAKCPILVQFTCVPRTAEDALTPDDVDSAAADEHGHGAGNSHSDPVSRPVVKACIFKMGDDCRQDQISLQLIGLIQRILNSVGVPSFLYPYRVITTGQSSGIIECVPRSRSRNEIGKLVESNVAEFFVQTFGHPESAGFRRARENFVRSTAAYSVVSFILNIKDRHNGNIMIDADGNLVHIDFGFLFDTSPGGDINFESSPFKLTTEMVQLIGMDVSGESTLQSKTLARALVDEENYIYFKTLVNRCYLAVRQYAREICVMVELMLRSGLPCFKPKKTIADLAQRLAVDKNEIEAADYMRRLIHESRQNFTTVLYDYYQKVAEGIEM
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260..---.....270.......280........290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890....-...900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740...---...1750......1760........1770...-...1780.....-----.1790......1800......1810......1820......1830......1840......1850......1860......1870......1880------......1890......1900.......1910......1920......1930......1940...--------..-----.1950--.........1960-..----....1970......1980......1990......2000......2010-------........2020......2030......2040....-.----.----------2050......2060......2070--........2080......2090------....-----...2100..---....2110......--------2120...--...2130.----------.-------....2140......2150-----........2160......2170......2180-.......2190....---..-----------------2200.---.-----------------------------......2210......2220---------......2230.....-------...2240--.....-....2250------..------.--.------...2260-......--.2270......2280-.--.----.----...----.2290......2300...-.....2310..-.....----2320..-....2330......2340--------...----------.-....2350.......2360.--.-----------..--------..2370.......2380......2390......2400......2410......2420......2430......2440......2450.....----...2460.------..--.--..--2470.......2480......2490......2500..-....2510......2520-......2530......2540......2550......2560......2570......2580......2590....-.-.2600-....--.--..2610......2620......2630.....-.2640......2650.....-----------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNDIRFPGWIKSS
P
T
L
V
M
A
S
V
L
A
Q
L
L
T
D
E
C
A
E
ATSSATAGAPRPPSEACVPDGRERWPRHNFG
E
D
I
S
S
SCSDGGGGVDLSDS
D
A
S
E
CEGCYDP
D
R
D
A
MHSGGGVD
T
G
Y
L
R
M
V
D
R
L
L
E
L
N
S
K
E
L
DSLPPAAATA
A
A
TTYLPPKAVTA
P
A
T
A
M
Q
T
A
IAGSWPRG
S
G
V
L
F
T
RQNGGVSMSNLGAS
P
D
ILRNP
R
V
R
T
L
L
R
L
S
R
L
N
D
V
L
T
R
A
E
A
A
Q
P
L
I
S
R
R
T
A
A
A
M
V
S
F
F
A
F
A
V
S
CRYSGLPVDRTK
G
F
F
T
E
C
S
A
L
Y
T
T
L
L
S
K
L
R
S
LR---FGGGV
S
L
E
D
F
T
A
A
L
V
AC-G
L
K
L
RCDEDVEGDEKDGHGGTNEAGVTGAGTAGIPCSGRSNSSSAVASGAAPMGSCGGAGVRTPTQPSFGRDKNY
G
L
VGF
G
H
R
A
L
D
A
I
F
V
R
CIP
S
N
I
D
E
C
VHD
P
V
A
L
G
V
L
RGISLTHS
Q
Q
L
F
YL
G
P
E
L
V
N
H
L
H
D
L
T
D
A
F
AT
S
S
H
R
R
E
L
S
Y
K
R
V
L
S
V
L
L
E
A
ISCS
R
V
I
D
YERTN
N
W
I
T
A
V
I
Q
E
R
Y
V
V
R
G
L
F
Q
R
E
E
L
H
A
H
V
V
T
A
T
L
T
M
L
I
R
Q
Y
Q
E
M
A
K
E
C
A
S
K
V
V
DLGSMPDFTE
G
D
Q
L
I
E
L
V
W
K
A
L
Q
D
T
IG
S
W
E
D
A
VTTAEKHP
L
T
L
F
RH
N
I
D
M
V
V
Q
H
L
L
R
T
E
V
E
R
L
R
C
Y
Y
I
I
TS
A
T
A
A
Y
H
Q
S
L
VGMSAGTRTTRNQSGCPPAVPQLAPG
R
E
E
QRGASQRGRDTLRGQDGNTRRDSDAPAAAPYVPSAEEE
S
L
R
I
L
I
C
S
N
I
I
K
L
L
LL
P
T
S
I
M
N
ALPR
T
E
E
A
K
Q
L
R
A
S
L
T
E
A
A
A
R
V
L
S
V
V
T
A
K
E
FKSRD
D
T
S
V
M
K
AASGRATTSAAPRSISP
I
S
A
A
AAMPRIRRTDAAAAG
T
D
L
F
V
I
S
Q
R
R
A
H
FSN
N
F
Y
R
C
I
E
E
L
I
H
E
L
I
H
T
I
L
Q
QSVPD
D
A
T
A
VANRSFLGGVPDVHPPTPPTSDA
S
S
D
A
I
L
R
G
M
V
A
A
V
C
I
Q
Y
M
CST
N
Q
H
L
R
S
F
A
I
S
E
V
M
D
A
V
V
R
L
S
A
RCGAEEAATATHGSLGRKGSSHTARASGNNSNGSPAAA-PQG
T
V
V
GAAAAD
P
E
E
E
R
K
H
A
T
H
L
R
A
R
Q
L
A
L
C
F
D
A
L
S
A
I
L
V
P
T
V
V
V
E
G
Y
H
H
V
A
E
E
Q
E
E
R
AGLARSCTTTSARGD
S
K
R
E
E
L
S
R
Y
G
Q
L
L
C
D
T
Y
V
D
S
L
R
E
H
L
W
SLGEGSVSR
H
K
L
L
T
P
V
M
T
V
A
V
K
A
F
V
N
L
V
L
R
V
H
E
R
LR
G
M
S
S
M
A
L
A
L
V
Q
E
A
E
A
AREGPGKGTRRSA
G
V
I
A
R
D
R
A
R
L
L
H
A
F
N
A
E
R
M
S
V
V
L
L
L
R
G
V
I
Q
N
M
L
S
VAWPSSG
V
L
YQDPACGWERPL
N
K
T
T
S
A
V
M
A
P
L
A
L
A
V
L
S
P
F
F
R
P
L
T
M
L
L
H
L
S
T
LF
P
V
R
S
L
K
Q
L
C
T
H
Y
Q
Y
A
R
Y
L
T
LEDPSTSD
Q
Y
M
F
Y
Y
Y
R
R
L
S
R
A
L
V
AAEADDSGGSGAGP
A
E
Q
V
E
L
E
C
W
A
L
F
R
S
C
W
M
M
F
S
Y
Y
K
Y
T
A
E
A
L
M
A
V
RAGGMAPMESA
N
P
A
A
A
A
A
A
L
A
RAPILS
T
K
Q
C
K
L
L
R
L
I
A
A
S
A
A
P
L
L
R
M
C
S
S
D
V
Q
Q
A
M
A
D
V
A
V
L
L
R
Y
T
L
AGALHC
P
M
V
V
A
DVTAKSGI
V
H
A
S
L
Y
K
S
L
K
R
L
CG
G
R
K
E
C
W
K
RLS
M
G
E
L
M
L
L
Q
C
V
A
E
L
E
I
L
R
A
AAGS
V
A
Q
L
T
L
Y
R
H
F
E
V
R
E
F
V
A
S
A
A
I
P
E
A
L
G
H
I
L
S
T
A
C
D
H
Y
I
E
A
V
R
S
MLPG
V
A
F
Q
V
T
R
T
D
L
M
Q
L
V
F
L
V
G
F
A
I
G
S
V
R
E
S
A
S
K
L
V
L
C
V
V
RSFP
T
Y
A
A
Y
A
S
A
L
P
L
L
W
C
M
L
D
L
LEAGTA
G
Q
I
E
S
L
C
E
H
V
RFSTVPAVAADPHSV
E
R
Q
Q
H
V
L
F
V
A
D
V
A
E
R
W
A
A
I
L
QDKA
P
I
A
L
F
E
T
A
I
K
F
M
V
I
Q
Q
Q
ECG
E
Q
A
T
T
QAGRHHAG
S
R
L
A
V
L
A
S
L
Y
R
VEETPPNLDDS
A
I
T
V
M
RGAGAAG
H
V
V
K
T
E
Y
A
Q
T
L
L
LHGRAQGAM
Q
A
S
S
W
YASAG
Q
M
Q
S
T
V
V
A
Q
L
W
A
A
T
R
L
C
R
R
A
L
A
S
A
V
A
Q
R
L
E
S
N
LL
R
P
A
R
A
L
F
V
ETGYSVG
T
V
LAPRASTVAD
E
D
A
A
A
Q
EMGVTRVPLGAP
A
R
A
E
T
A
A
S
F
A
A
A
V
A
L
L
V
TGSGTP
I
G
R
R
Q
L
L
Q
Y
L
V
Q
G
A
V
Q
T
F
R
S
---
D
V
L
Y
E
A
I
L
C
W
K
W
L
L--SQNRE
A
Y
L
L
P
M
L
Q
EL
D
-
T
A
F
V
W
TAANRLG-----LFDGYCSSKN
R
Q
VQTGDVPIPHN
T
V
S
ARGQRGARVPE
E
A
A
V
Y
V
ADNVDSA
S
P
H
K
L
L
L
S
F
L
A
D
M
Y
VEEGSPLCL
S
P
E
V
L
R
Q
L
Y
L
V
A
A
H
I
M
Q
F
A
A
V
L
------
S
L
R
D
D
M
F
G
E
T
M
R
C
F
L
V
V
G
-
S
I
A
Q
L
L
R
E
A
N
V
R
Q
L
R
A
G
L
L
T
LVP
F
P
A
I
G
A
L
R
Q
R
W
Y
K
A
L
L
R
W
F
TKT--------PP-----SW-----YYAKDP
V
L
A
R
E
E
A
-
K
V
----
L
S
S
L
S
Q
L
I
K
E
E
A
D
L
L
T
R
T
T
LG
F
L
DFSSGVQRERDMP
H
V
H
H
W
E
S
L
S
V
---------
V
R
E
A
V
A
A
V
R
QATDGGEAG
L
P
K
L
I
V
R
E
K
L
R
L
Q
G
L
L
H
L
-
L
----
R
----------
V
L
V
E
H
E
V
L
R
L
S
VWRTPR
R
T
L
KI----PNTTPSV
G
W
G
K
L
I
E
C
ADHHNP-------
E
V
V
V
-----
A
M
V
Y
R
FSSI---
P
A
V
R
L
AASQRVVAH--------
P
E
R
Y
S
N
V
--
A
E
A
V
D
L
Y
L
----------
T
-------
E
D
V
L
R
AGA
P
R
L
F
L
F
C-
S
------
C
T
I
I
Q
A
L
R
LLDP
R
Y
A
A
Y
K
T
V
N
S
Y
A
I
R
S
L
L
S
-Q-RS
E
K
L
I
F
Y
L
P
Q
L
L
Q
L
---LA-----------------TD--E---S-----------------------------G
S
I
E
A
F
L
V
RTSA
R
S
T
M
F
A
H
Q
---------
L
L
W
S
LQT--ESEGS
G
-------
A
L
A
K
-----
K
C
Q
Q
V
-
E
R
R
I
K
AA-------FT------P--
N
------
E
E
A
F
Y
R
--
S
E
F
A
F
V
--
D
L
M
T
S
LSG
E
I
MKF-D-K--P----
E
----
R
K
A
----
Q
L
R
L
R
L
K
D
D
V
F
H
A
--
L
P
K
-
L
R
H
L
YLPT-DP-N
Y
R
I
T
----
D
VIPHT-
A
G
A
M
Q
SAAKC
P
I
L
V
Q
F
----------TCV----------P-RTAEDAL-TPDDV
D
S
AAADE--H-----------GH--------GAGN-SHSDPVS
R
P
V
V
K
A
C
I
F
KMGDD
C
R
Q
D
Q
I
S
L
Q
L
I
G
L
I
Q
R
I
L
N
SVGVPSF
L
Y
P
Y
R
V
I
TTGQSS
G
I
I
E
C
VPRSR
S
R
N
E
I
G
K
L
V
--
E
S
N
V
A
E
----
F
F
V
Q
T
FGH------PE--S--A
G
--
F
R
-
R
A
R
E
N
F
V
R
S
T
A
A
Y
S
V
V
S
F
I
L
N
IKDRHNG
N
I
M
I
DA-DG
N
L
V
H
I
D
F
G
F
L
F
DTSPG-GDINFESS
P
F
K
L
T
T
E
M
V
Q
L
IGMDVSGES
T
L
Q
S
K
T
L
A
R
A
L
VDEE
N
Y
I
Y
F
K
T
L
V
N
R
C
Y
L
A
V
R
Q
Y
A
R
E
I
C
V
M
V
E
L
M
L
-R-SGLP--CFKP--
K
--
K
T
I
A
D
L
A
Q
R
LAVDKNEI
E
A
A
D
Y
M
R
R
L
I
H
E
S
R-Q
N
F
T
T
V
L
Y
D
Y
Y
Q
K
V
A
EGIEM-----------
53
Fugue
70.00
19%
-32
- C2 -
-
1E8X
1
PK3CG_PIG
A:
[1-951]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
-
S
E
E
T
L
A
F
Q
R
Q
L
N
-----
A
L
I
G
Y
D
V
T
D
V
S
N
V
H
D
D
E
L
E
F
T
R
R
R
L
V
T
P
R
M
A
E
V
A
G
R
D
P
K
L
Y
A
M
H
P
W
V
T
S
K
P
L
P
E
Y
L
L
K
K
I
T
N
----
N
C
V
F
I
V
I
H
R
S
T
T
S
Q
T
I
K
V
S
A
D
D
T
P
G
T
I
L
Q
------
S
F
F
T
K
M
A
N
E
R
D
F
V
L
R
V
C
G
-
R
----------
D
E
Y
L
V
G
E
T
P
I
K
N
F
Q
W
V
R
Q
C
L
K
N
G
E
E
I
H
L
V
L
D
T
P
P
--------
D
P
-----
A
L
-----
D
E
V
R
K
E
C
D
R
K
F
R
V
-
K
I
R
G
I
D
I
P
V
L
P
R
T
A
D
L
T
V
F
V
E
A
N
I
Q
Y
G
Q
Q
V
L
C
Q
R
R
T
S
P
K
P
F
T
E
E
V
L
W
N
V
W
L
E
---------
F
S
I
K
I
K
D
L
P
K
G
A
--------
L
L
N
L
Q
I
Y
C
Q
L
L
Y
Y
V
N
L
-
L
LIDH
R
----------
F
L
L
R
H
G
E
Y
V
L
H
M
W
Q
L
S
G
F
N
A
D
K
LTSA
T
N
P
D
K
E
N
S
M
S
I
S
I
L
L
D
N
H
P
I
A
LEMPN
Q
L
R
K
Q
L
-----
E
A
I
I
A
T
D
P
L
---
N
P
L
T
A
E
D
K
E
L
L
W
H
F
--------
R
Y
E
S
L
K
D
--
P
K
A
Y
P
K
L
F
S
S
VKWGQ
Q
E
I
V
-------
A
K
T
Y
Q
L
L
A
K
R
E
V
W
D
Q
S
A
------
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
-
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
-
L
-
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
---
V
K
FE---------------
P
Y
--
H
---
D
-----------------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
---------
L
F
W
F
L
R
S
--
E
I
A
Q
S
R
-------
H
Y
Q
Q
-----
R
F
A
V
I
-
L
E
A
Y
L
R
G
-------
C
G
------
T
--
A
------
M
L
H
D
F
T
--
Q
Q
V
Q
V
I
--
D
M
L
Q
K
V
T
I
D
I
K
S
L
-
S
-
A
--
E
----
K
YDVS
S
Q
V
----
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
--
L
N
L
-
P
Q
S
F
R
V
P
Y
-
D
P
-
G
L
K
A
G
----
A
L
V
I
E
K
-
C
K
V
M
A
S
K
K
K
-
P
L
W
L
E
F
----------
K
C
A
----------
D
-
P
T
A
L
S
N
E
-
T
---------------------------------------------------
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
--
V
G
N
T
G
A
FKDE
V
L
S
H
W
L
K
E
K
C
----
P
I
--
E
--
E
K
--
F
Q
-
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
S
E
-
T
G
N
L
F
H
I
D
F
G
H
V
---------------
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
--------------
L
H
F
Q
K
F
Q
D
V
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
-
M
-
T
G
M
P
--
Q
L
T
S
--
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
S
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
-
D
K
G
W
T
V
Q
F
N
W
F
L
H
L
V
L
---------------
58
Fugue
62.27
16%
3
- C2 -
-
5H64
-
MTOR_HUMAN
A:
[210-2549]
-----------------
V
A
A
L
R
A
C
L
I
L
T
T
------------
Q
R
E
P
K
E
M
----
Q
K
P
Q
W
Y
R
H
T
F
E
E
A
------
E
K
G
F
D
E
T
L
A
K
E
K
G
-------------
M
N
R
D
D
R
I
H
-
G
A
L
L
I
L
N
E
L
V
R
I
S
S
M
E
G
E
R
L
R
E
E
M
E
E
I
T
Q
Q
Q
L
V
H
D
K
Y
C
-
K
D
L
M
G
F
G
T
K
P
R
H
I
T
P
F
T
S
F
Q
A
V
Q
P
Q
Q
S
N
A
L
V
G
L
L
G
Y
S
S
H
Q
G
L
M
G
F
G
T
S
P
---
S
P
A
K
S
T
L
V
E
S
R
C
C
R
D
L
M
E
E
K
F
D
Q
V
C
----
Q
W
V
L
K
C
R
N
S
K
N
S
L
I
Q
M
T
---------
I
L
N
L
L
P
R
L
A
A
F
R
PSA
F
T
D
T
Q
Y
L
Q
D
T
M
N
H
V
L
S
C
V
K
V
L
Y
D
L
S
R
Q
I
P
Q
L
K
K
D
I
Q
D
G
L
L
K
M
L
S
L
V
L
M
H
K
P
L
R
H
P
G
M
P
K
G
L
A
H
Q
L
A
--------------
S
P
G
L
T
T
L
P
E
A
S
D
V
G
S
I
T
L
A
L
R
T
L
G
---------------------------------
S
F
E
F
E
G
H
S
L
T
Q
F
V
R
H
C
A
D
H
F
L
N
S
E
H
K
E
I
R
--------
M
E
A
A
R
T
C
S
R
L
L
------------
T
P
S
I
H
L
I
S
G
-------
H
A
H
V
V
S
-------
Q
T
A
V
Q
V
V
A
D
V
L
S
K
L
L
V
V
G
I
T
------
D
P
D
P
D
I
R
Y
C
V
L
A
S
L
D
E
R
F
D
A
H
L
A
Q
A
E
N
L
Q
A
L
F
V
A
L
N
----------
D
Q
V
F
E
I
R
E
L
A
I
C
T
------------------
V
G
R
L
S
S
M
N
P
A
F
V
M
P
F
L
R
K
M
L
I
Q
I
L
T
E
L
E
H
S
G
I
G
R
I
K
E
Q
S
A
R
M
L
G
H
L
V
S
N
A
P
R
L
I
R
P
Y
M
E
P
--------
I
L
K
A
L
I
L
K
L
K
D
P
D
P
D
P
N
P
G
V
I
N
N
V
L
A
T
I
----
G
E
L
A
Q
V
S
G
L
E
M
R
K
W
V
D
E
L
F
I
I
I
M
D
M
L
Q
D
S
S
L
L
A
K
R
Q
V
A
L
W
T
L
G
Q
L
V
A
S
T
G
Y
V
V
E
P
Y
R
K
-----------------
Y
P
T
L
L
E
V
L
L
N
F
L
K
T
E
Q
N
Q
G
T
R
R
E
A
-------------------------------------------------
I
R
V
L
G
L
L
G
A
L
D
P
Y
K
H
K
V
N
I
G
M
I
D
Q
S
R
D
A
S
A
V
S
L
S
E
S
K
S
S
Q
D
S
S
M
L
V
N
M
G
N
L
P
L
D
E
F
Y
P
A
V
S
M
V
A
L
M
R
I
F
R
D
Q
S
L
S
H
H
H
T
M
V
V
Q
A
I
T
F
I
F
K
S
L
G
L
K
C
V
--------
Q
F
L
P
Q
V
M
P
T
F
L
N
V
I
R
V
C
D
G
------
A
I
R
E
F
L
F
Q
Q
L
G
M
L
V
S
F
V
K
S
H
I
R
P
Y
M
D
E
I
V
T
L
M
R
E
F
W
V
M
N
T
S
I
Q
S
T
I
I
L
L
I
E
Q
I
V
V
A
L
G
G
E
F
K
L
Y
L
P
Q
L
I
P
H
M
L
R
V
F
M
H
D
N
S
P
G
R
------------------
I
V
S
I
K
L
L
A
A
I
Q
L
F
G
A
N
L
D
D
Y
L
H
L
L
L
P
P
I
V
K
L
F
D
A
P
----
E
A
P
L
P
S
R
K
A
A
L
E
T
V
D
R
L
T
---------------------------------------
E
S
L
D
F
T
D
-----
Y
A
S
R
I
I
H
P
I
V
R
T
L
D
Q
S
P
---------------------------
E
L
R
S
T
A
M
D
T
L
S
S
L
V
F
Q
L
G
K
K
Y
Q
I
F
I
P
M
V
N
K
V
L
V
R
H
R
I
N
H
Q
R
Y
D
V
L
I
C
R
I
V
K
G
Y
T
L
M
K
K
L
H
V
S
T
I
N
L
Q
K
A
----------------------------------
W
G
A
A
R
R
V
S
K
D
D
W
L
E
W
L
R
R
L
S
L
E
L
L
K
D
S
S
S
P
S
L
R
S
C
W
A
L
A
Q
A
--------
Y
N
P
M
A
R
D
L
F
N
A
A
F
V
S
C
W
S
E
L
N
E
D
Q
Q
D
E
L
I
R
S
I
E
L
A
L
T
S
Q
D
I
A
E
V
T
Q
T
L
L
N
L
A
E
F
M
E
H
S
D
K
G
------------------------
P
L
P
L
------------
R
D
D
N
G
I
V
L
L
G
E
R
A
A
K
C
R
A
Y
A
K
A
L
H
Y
K
E
L
E
F
Q
K
G
P
T
P
A
I
L
E
S
L
I
S
I
N
N
K
L
Q
Q
P
E
A
A
A
G
V
L
E
Y
A
M
K
H
F
G
E
L
E
I
Q
A
T
W
Y
E
K
L
H
E
W
E
D
A
L
V
A
Y
D
K
K
M
D
T
N
K
D
D
P
E
L
M
L
G
R
M
R
C
L
E
A
L
G
E
W
G
Q
L
H
Q
Q
C
C
E
K
W
T
L
V
N
D
E
T
Q
A
K
M
A
R
M
A
A
A
A
A
W
G
L
G
Q
-------
W
-------
D
S
M
E
E
Y
T
C
M
-
I
P
R
D
T
H
D
G
A
F
Y
R
A
V
L
A
L
H
Q
D
L
F
S
L
A
Q
Q
C
I
D
K
A
R
D
L
L
D
A
E
L
T
A
M
A
G
E
S
Y
S
R
A
Y
G
A
M
V
S
C
H
M
L
S
E
L
E
E
V
I
Q
Y
K
L
V
P
E
R
R
E
I
I
R
Q
I
W
W
E
R
L
Q
G
C
Q
R
I
---
V
E
D
W
Q
K
I
L
M
V
R
S
L
V
VS
P
H
E
D
M
R
T
W
L
K
Y
A
S
L
C
G
K
S
G
R
L
A
L
A
H
K
T
L
V
-----
L
L
L
G
V
D
P
S
R
Q
L
-----
D
H
P
L
P
T
V
----------------------------
H
P
Q
V
T
Y
A
Y
M
K
N
M
W
K
S
A
R
K
-----
I
D
A
F
Q
H
M
Q
H
F
V
Q
T
M
Q
Q
Q
A
Q
H
A
IATEDQ
Q
H
K
Q
E
L
H
K
L
M
A
R
C
F
L
K
L
G
-
E
W
Q
L
N
L
Q
G
I
N
E
S
T
I
P
K
V
L
Q
Y
Y
S
A
A
T
E
H
D
---
R
S
W
Y
K
A
W
H
A
W
A
V
M
N
--------
F
E
-----
A
V
-----
L
H
Y
K
H
Q
N
Q
A
R
D
E
K
K
K
V
----
T
E
D
L
S
K
T
L
L
M
Y
T
V
P
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
N
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
------------------------
G
H
W
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
--
I
D
T
-
W
----
L
----------
Q
V
I
P
Q
L
I
A
R
I
D
---
T
P
R
----------
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
-------
A
L
I
Y
-----
P
L
T
V
A
S
K
S
T
---
T
T
A
R
H
N
A
A
N
K
I
L
K
N
--------
M
C
E
H
S
N
T
--
L
V
Q
Q
A
M
M
V
----------
S
-------
E
E
L
I
R
V
A
-----
I
L
W
-
H
------
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
R
N
V
---------------
K
G
M
F
E
V
L
E
P
L
H
A
M
---
M
E
-----------------
R
G
--
P
---
Q
-----------------------------
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
---------
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
-------
Q
A
W
D
-----
L
Y
Y
H
V
-
F
R
R
I
S
K
Q
-------
L
P
------
Q
LT
S
------
L
E
L
Q
Y
V
--
S
P
K
L
L
M
CR
D
L
E
L
A
V
P
G
T
Y
D
P
N
-
Q
-
P
--
I
----
I
----
R
I
Q
----
S
I
A
P
S
L
Q
V
I
T
S
K
Q
--
R
P
R
-
K
L
T
L
M
G
S
N
-
G
H
-
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
-
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
----------
D
------------
P
-
T
S
L
R
K
N
L
-
S
I
Q
R
Y
A
V
I
P
L
S
T
--
N
S
----------
G
L
--------
I
G
W
V
-
P
H
C
D
T
---------
L
H
A
L
I
R
D
Y
R
E
K
K
K
--
I
L
L
N
I
E
H
R
I
M
L
R
M
A
-----
P
D
Y
D
H
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
A
G
D
D
L
A
K
L
L
--
W
L
K
S
--------------------
P
S
--
S
--
E
V
--
W
F
-
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
F
E
V
A
M
T
-
R
E
K
F
P
E
K
I
P
F
R
L
T
-------------------
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
-
Y
-
D
P
L
L
--
N
W
R
L
--
M
--
D
T
N
T
A
L
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
S
H
D
D
T
-
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
CYIGWCPFW
55
Fugue
61.70
22%
-2
- C2 -
-
4TUU
-
PK3CA_HUMAN
A:
[107-1046]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
E
K
I
L
N
R
E
I
G
F
A
I
-----
G
M
P
V
---
C
E
F
D
M
V
K
D
P
E
V
Q
D
F
R
R
N
I
L
N
V
C
K
E
A
V
D
L
R
D
L
N
S
--
P
H
S
R
A
M
Y
V
Y
P
P
N
V
E
S
S
-
P
E
L
P
K
H
I
Y
N
K
L
D
KG
Q
I
I
V
V
I
W
V
I
V
S
P
N
N
D
K
Q
K
Y
T
L
K
I
N
H
D
C
V
P
E
Q
V
I
A
E
A
I
R
K
K
T
R
S
M
L
-------
Y
Q
G
K
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
M
P
N
L
M
L
M
A
K
E
------
S
L
Y
S
Q
L
---
P
M
D
C
F
T
M
P
S
Y
S
R
K
S
L
W
V
I
N
S
A
L
R
I
K
I
L
C
A
T
Y
V
N
V
N
D
K
I
Y
V
R
T
G
I
Y
H
G
G
E
P
L
C
D
N
V
N
T
Q
RVPCS
N
P
-----
R
W
N
E
W
L
N
Y
D
I
Y
I
P
D
L
P
R
A
-
A
-
R
L
----
C
L
S
I
C
S
V
-
K
E
E
H
C
P
L
A
W
G
N
I
N
L
F
D
Y
T
D
--
T
L
V
S
G
K
M
A
L
N
L
W
P
V
P
H
G
---------
L
E
D
L
L
N
P
I
G
V
T
G
S
N
P
N
K
E
T
P
C
L
E
L
E
F
D
W
F
S
S
V
V
K
F
P
D
M
----
S
----------
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
H
A
G
----
L
S
N
R
L
A
R
D
-
N
E
L
R
E
N
D
K
E
Q
L
K
-------
A
I
S
T
-----
R
D
P
L
S
E
I
T
E
---
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
T
I
------
P
E
I
L
P
K
L
--
L
L
S
V
K
-
W
N
----------
S
-------
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
-
P
------
I
K
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
-
P
M
V
R
G
F
A
V
R
C
L
E
K
-
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
---
L
K
-----------------
Y
E
--
Q
YL-
D
-----------------------------
N
L
L
V
R
F
L
L
K
K
A
L
T
N
Q
R
I
G
H
F
---------
F
F
W
H
L
K
S
--
E
M
H
N
K
T
-------
V
S
Q
R
-----
F
G
L
L
L
-
E
S
Y
C
R
A
C
---------------
G
--
M
------
Y
L
K
H
L
N
--
R
Q
V
E
A
M
--
E
K
L
I
N
L
T
D
I
L
K
Q
E
-
K
-
K
--
D
----
E
T---
Q
K
V
----
Q
M
K
F
L
V
E
Q
M
R
R
P
D
--
F
M
D
A
L
Q
G
F
L
S
P
L
-
N
P
-
A
H
Q
L
G
----
N
L
R
L
E
E
-
C
R
I
M
S
S
A
K
R
-
P
L
W
L
N
W
----------
E
----------------------
N
P
D
I
M
S
E
L
L
F
Q
----------------------------------------
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
-----
K
G
F
N
S
----
H
T
L
H
Q
W
L
K
------
D
K
--
N
--
K
G
E
I
Y
D
-
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
-
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
-----------
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
S
------------------
T
K
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
-
G
-
S
G
M
P
--
E
L
Q
S
--
F
--
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
---------------------------------
27
HHSearch
61.69
25%
-0
- C2 -
-
4UWH
1
PK3C3_HUMAN
A:
[30-595]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
Y
E
E
Q
D
L
V
W
K
F
R
YYLTNQ-
E
K
A
L
T
K
F
--
L
K
C
V
N
W
D
L
----------
P
-------
Q
E
A
K
Q
-
A
L
E
L
L
G
K
W
K
-
P
------
M
D
V
E
D
S
L
E
L
L
S
S
H
Y
T
-
N
P
T
V
R
R
Y
A
V
A
R
L
R
Q
-
A
-
D
D
E
D
L
L
M
Y
L
L
Q
L
V
Q
A
---
L
K
-----------------
Y
E
--
N
---
F
D
D
I
K
N
G
LEPINSAEIDSSQIITSPLPNLE
Q
D
L
C
T
F
L
I
S
R
A
C
K
N
S
T
L
A
N
Y
---------
L
Y
W
Y
V
I
V
--
E
C
E
D
Q
D
T
Q
Q
RD
P
-
K
T
H
E
-----
M
Y
L
N
V
-
M
R
R
F
S
Q
A
-------
L
L
K
GD
K
S
V
R
--
V
------
M
R
S
L
L
A
--
A
Q
Q
T
F
V
--
D
R
L
V
H
L
M
K
A
V
Q
R
E
-
S
-
G
--
N
R
K
--
K
----
K
N
E
----
R
L
Q
A
L
L
G
D
N
E
K
M
N
--
L
S
D
-
V
E
L
I
P
L
P
L
-
E
P
-
Q
V
K
I
R
----
G
I
I
P
E
T
-
A
T
L
F
K
S
A
-
L
M
P
A
Q
L
F
F
----------
K
T
E
--------------------------------------------------------------------
D
G
G
K
Y
P
V
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
I
I
S
L
M
D
K
L
L
R
K
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
T
K
H
G
F
M
Q
F
I
Q
S
-
V
P
V
A
E
V
L
D
T
E
---
G
S
I
Q
N
----
F
F
R
K
Y
A
P
S
------
E
N
GP
N
--
G
I
--
S
A
-
E
V
M
D
T
Y
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
L
T
K
-
T
G
K
L
F
H
I
D
F
G
Y
I
L
G
R
D
P
K
-----
P
L
P
P
P
M
K
L
N
K
E
M
V
E
G
M
G
G
T
-----------------
Q
S
E
Q
Y
Q
E
F
R
K
Q
C
Y
T
A
F
L
H
L
R
R
Y
S
N
L
I
L
N
L
F
S
L
M
V
-
D
-
A
N
I
P
--
D
I
A
L
E
P
D
--
K
T
V
K
K
V
Q
D
K
F
R
L
D
L
S
D
E
E
A
V
H
Y
M
Q
S
L
I
D
E
S
V
-
H
A
L
F
A
A
-------------------------
32
HHSearch
60.84
26%
-10
* C2 *
-
5VLR
1
PK3CD_HUMAN
A:
[507-1011]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
E
H
E
K
D
L
V
W
K
L
R
H
E
V
Q
E
HF
P
E
A
L
A
R
L
--
L
L
V
T
K
W
N
K
----------
H
-------
E
D
V
A
Q
M
L
-
Y
L
L
C
S
W
P
-
E
------
L
P
V
L
S
A
L
E
L
L
D
F
S
F
P
-
D
C
H
V
G
S
F
A
I
K
S
L
R
K
-
L
-
T
D
D
E
L
F
Q
Y
L
L
Q
L
V
Q
V
---
L
K
-----------------
Y
E
--
S
YL-
D
-----------------------------
C
E
L
T
K
F
L
L
D
R
A
L
A
N
R
K
I
G
H
F
---------
L
F
W
H
L
R
S
--
E
M
H
V
P
--------
S
V
A
L
-----
R
F
G
L
I
-
L
E
A
Y
C
R
G
-------
S
T
------
H
---------
H
M
K
V
L
M
--
K
Q
G
E
A
L
--
S
K
L
K
A
L
N
D
F
V
K
L
S
-
S
-
Q
--
K
TP
K
P
Q
----
T
K
E
----
L
M
H
L
C
M
R
Q
E
A
--
Y
--
L
E
A
-
L
S
H
L
Q
S
P
L
-
D
P
-
S
T
L
L
A
----
E
V
C
V
E
Q
-
C
T
F
M
D
S
K
-
M
K
P
L
W
I
M
Y
----------
S
N
E
----------
E
-
A
----------------------------------------------------------
S
V
G
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
M
I
Q
L
M
D
V
L
W
K
Q
E
G
L
D
L
R
M
T
P
Y
G
C
L
P
T
G
D
R
T
G
L
I
E
V
V
L
R
S
D
T
I
A
N
I
Q
L
N
-FN
K
D
A
L
L
N
----
W
L
K
S
K
N
P
G
-------------
E
A
--
L
D
-
R
A
I
E
E
F
T
L
S
C
A
G
Y
C
V
A
T
Y
V
L
G
I
G
D
R
H
S
D
N
I
M
I
R
E
-
S
G
Q
L
F
H
I
D
F
G
H
F
L
G
N
F
-----
I
N
R
E
R
V
P
F
I
L
T
Y
D
F
V
H
V
I
Q
Q
G
-
K
T
-------------
N
N
S
E
K
F
E
R
F
R
G
Y
C
E
R
A
Y
T
I
L
R
R
H
G
L
L
F
L
H
L
F
A
L
M
R
-
A
-
A
G
L
P
--
E
L
S
C
--
S
--
K
D
I
Q
Y
L
K
D
S
L
A
L
G
K
T
E
E
E
A
L
K
H
F
R
V
K
F
N
E
A
L
-
R
E
S
W
---------------------------
54
Fugue
60.31
28%
-30
- C2 -
-
4D0L
2
PI4KB_HUMAN
A:
[10-566]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
L
L
R
L
F
E
S
K
-
L
------
F
D
I
S
M
A
I
S
Y
L
Y
N
S
K
E
--
P
G
V
Q
A
Y
I
G
N
R
L
F
C
-
F
-
R
N
E
D
V
D
F
Y
L
P
Q
L
L
N
M
---
Y
I
HMD--------------
E
D
--
V
---
G
-----------------------------
D
A
I
K
P
Y
I
V
H
R
C
R
Q
S
I
N
F
S
L
Q
---------
C
A
L
L
L
G
A
--
Y
S
S
R
G
T
-------
K
L
R
K
-----
L
I
L
S
R
-------------------------------------
L
A
--
P
E
R
E
F
I
--
K
S
L
M
A
I
G
K
R
L
A
T
L
-
P
-
T
--
K
----
E
----
Q
K
T
----
Q
R
L
I
S
E
L
S
L
L
N
H
K
--
L
P
A
---
R
V
W
L
P
T
A
G
F
-
D
H
H
V
V
----
R
V
P
H
T
Q
-
A
V
V
L
N
S
K
D
K
A
P
Y
L
I
Y
V
----------
E
V
L
E
C
ENFDTTSV
P
-
A
R
I
P
E
N
P
-
S
A
V
A
L
K
E
P
W
Q
E
K
--
V
-----------
R
R
--------
I
R
E
G
-
S
P
Y
G
H
L
P
N
W
R
L
L
S
V
I
V
K
C
G
D
D
L
R
Q
E
L
L
A
F
Q
V
L
K
Q
L
Q
S
I
W
E
Q
E
R
V
P
L
W
I
K
P
Y
K
I
L
V
I
S
A
D
S
G
M
I
E
P
V
V
N
A
V
S
I
H
Q
V
K
K
Q
S
--
Q
L
S
L
L
D
----
Y
F
L
Q
E
H
G
S
------
Y
T
--
T
--
E
A
--
F
L
-
S
A
Q
R
N
F
V
Q
S
C
A
G
Y
C
L
V
C
Y
L
L
Q
V
K
D
R
H
N
G
N
I
L
L
D
A
-
E
G
H
I
I
H
I
D
F
G
F
I
L
S
S
S
----------
S
A
F
K
L
T
T
E
F
V
D
V
M
G
G
-----------------
L
D
G
D
M
F
N
Y
Y
K
M
L
M
L
Q
G
L
I
A
A
R
K
H
M
D
K
V
V
Q
I
V
E
I
M
Q
-
Q
G
S
Q
L
P
--
C
F
H
G
--
S
--
S
T
I
R
N
L
K
E
R
F
H
M
S
M
T
E
E
Q
L
Q
L
L
V
E
Q
M
V
D
G
S
M
-
R
S
-----------------------------
56
Fugue
60.29
22%
-13
- C2 -
-
5DFZ
-
VPS34_YEAST
C:
[4-875]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
I
T
F
C
V
S
Q
D
L
D
V
P
L
K
V
K
I
K
S
L
E
G
H
K
P
L
L
------
K
P
S
Q
K
I
L
N
P
E
L
------------
M
L
I
G
S
N
V
F
P
S
S
D
L
I
V
S
L
Q
V
F
D
-----
K
E
R
N
R
N
L
T
L
P
I
Y
T
P
Y
--------
I
P
FRNSR
T
W
D----
Y
W
L
T
L
P
I
R
I
K
Q
---------
L
T
F
S
S
H
L
R
I
I
L
W
E
Y
N
G
S
K
Q
I
P
F
F
N
L
E
T
S
I
F
N
L
K
D
C
T
L
K
R
G
F
E
S
L
K
F
RYDVIDHCE
V
V
T
D
N
K
D
Q
E
N
L
N
K
Y
F
Q
G
E
F
T
R
L
P
W
L
D
E
I
T
I
S
K
L
R
K
Q
-
R
----
E
NRTWPQGTFV
L
N
L
E
F
P
M
L
E
L
P
V
V
F
I
E
R
E
I
M
N
-----
T
N
D
P
I
E
E
K
Y
R
R
L
E
R
A
S
K
N
A
N
L
-------
D
K
Q
V
KPDIK
K
R
D
Y
L
N
K
I
I
NYP
P
G
T
K
L
T
A
H
E
K
G
S
I
W
--------
K
Y
R
Y
Y
L
M
NN
K
K
A
L
T
K
L
L
----------
Q
-------
S
T
N
L
R
E
E
S
E
R
V
E
V
L
E
-
L
MDSWAE
I
D
I
D
D
A
L
E
L
L
G
S
T
F
K
N
-
L
S
V
R
S
Y
A
V
N
R
L
K
K
-
A
-
S
D
K
E
L
E
L
Y
L
L
Q
L
V
E
A
---
V
C
FENLSTFSDKSNSEFTI
V
D
--
A
---
V
-----------------------------
S
P
L
A
E
F
L
I
R
R
A
L
V
N
P
R
L
G
S
F
---------
F
Y
W
Y
L
K
S
--
E
S
E
D
K
P
-------
Y
L
D
Q
-----
I
L
S
S
F
-
W
S
R
L
D
-----------------
K
--
K
------
S
R
N
I
L
N
--
D
Q
V
R
L
I
--
N
V
L
R
E
C
C
E
T
I
K
R
L
K
D
-
T
--
T
----
A
----
K
K
M
----
E
L
L
V
H
L
L
E
T
K
V
R
P
--
L
V
K
-
V
R
P
I
A
L
P
L
-
D
P
-
D
V
L
I
C
----
D
V
C
P
E
T
-
S
K
V
F
K
S
S
L
S
-
P
L
K
I
T
F
----------
K
--------------------------------------------------------------------
T
T
L
N
Q
P
Y
H
L
M
F
K
V
G
D
D
L
R
Q
D
Q
L
V
V
Q
I
I
S
L
M
N
E
L
L
K
N
E
N
V
D
L
K
L
T
P
Y
K
I
L
A
T
G
P
Q
E
G
A
I
E
F
I
P
N
D
T
L
A
S
I
L
S
K
Y
---
H
G
I
L
G
Y
----
L
K
L
H
Y
P
D
E
------
N
A
--
T
--
L
G
--
V
Q
G
W
V
L
D
N
F
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
V
T
P
-
D
G
H
F
F
H
A
D
F
G
Y
I
L
G
Q
D
P
K
-
P
----
F
P
P
L
M
K
L
P
P
Q
I
I
E
A
F
G
G
A
-----------------
E
S
S
N
Y
D
K
F
R
S
Y
C
F
V
A
Y
S
I
L
R
R
N
A
G
L
I
L
N
L
F
E
L
M
K
-
T
-
S
N
I
P
DI
R
I
D
P
--
N
--
G
A
I
L
R
V
R
E
R
F
N
L
N
M
S
E
E
D
A
T
V
H
F
Q
N
L
I
N
D
S
V
-
N
A
L
L
P
I
V
I
D
H
L
H
N
L
A
Q
Y
W
R
T
-----------
33
HHSearch
59.42
27%
-20
- C2 -
-
5C46
1
PI4KB_HUMAN
E:
[18-527]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
S
K
-
L
------
F
D
I
S
M
A
I
S
Y
L
-
Y
N
S
K
-
E
P
G
V
Q
A
Y
I
G
N
R
L
F
C
-
F
-
R
N
E
D
V
D
F
Y
L
P
Q
L
L
N
M
---
Y
I
-----------------
H
M
--
D
EDV
G
-----------------------------
D
A
I
K
P
Y
I
V
H
R
C
R
Q
S
I
N
F
S
L
Q
---------
C
A
L
L
L
G
A
--
Y
S
--------------
S
-----
R
G
T
K
L
-
R
K
L
I
L
S
D
----------------------------
R
L
A
--
P
E
R
E
F
I
--
K
S
L
M
A
I
G
K
R
L
A
T
L
-
P
T
K
--
E
----
Q
----
K
T
Q
----
R
L
I
S
E
L
S
L
L
N
H
K
-----
L
-
P
A
R
V
W
L
P
T
-
A
G
F
D
H
H
V
V
----
R
V
P
H
T
Q
-
A
V
V
L
N
S
K
D
K
A
P
Y
L
I
Y
V
----------
E
V
L
----------
E
-
C
E
N
F
D
T
T
S
V
P
A
R
I
P
------DP
S
AVALKEPWQEK
V
R
--------
R
I
R
E
G
S
P
Y
G
H
L
P
N
W
R
L
L
S
V
I
V
K
C
G
D
D
L
R
Q
E
L
L
A
F
Q
V
L
K
Q
L
Q
S
I
W
E
Q
E
R
V
P
L
W
I
K
P
Y
K
I
L
V
I
S
A
D
S
G
M
I
E
P
V
V
N
A
V
S
I
H
Q
V
K
K
Q
S
--
Q
L
S
L
L
D
----
Y
F
L
Q
E
H
G
S
------
Y
T
--
T
--
E
A
--
F
L
-
S
A
Q
R
N
F
V
Q
S
C
A
G
Y
C
L
V
C
Y
L
L
Q
V
K
D
R
H
N
G
N
I
L
L
D
A
-
E
G
H
I
I
H
I
D
F
G
F
I
L
S
S
S
P
---------
S
A
F
K
L
T
T
E
F
V
D
V
M
G
G
L
-----------------
D
G
D
M
F
N
Y
Y
K
M
L
M
L
Q
G
L
I
A
A
R
K
H
M
D
K
V
V
Q
I
V
E
I
M
Q
Q
G
-
S
Q
L
P
--
C
F
H
G
--
S
--
S
T
I
R
N
L
K
E
R
F
H
M
S
M
T
E
E
Q
L
Q
L
L
V
E
Q
M
V
D
G
S
M
--------------------------------
26
HHSearch
58.96
25%
7
- C2 -
-
4JPS
1
PK3CA_HUMAN
A:
[542-1061]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
HYCVTI-
P
E
I
L
P
K
L
--
L
L
S
V
K
W
N
S
----------
R
-------
D
E
V
A
Q
-
M
Y
C
L
V
K
D
W
P
-
P
------
I
K
P
E
Q
A
M
E
L
L
D
C
N
Y
P
-
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
-
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
---
L
K
-----------------
Y
E
--
Q
YL-
D
-----------------------------
N
L
L
V
R
F
L
L
K
K
A
L
T
N
Q
R
I
G
H
F
---------
F
F
W
H
L
K
S
--
E
M
H
N
K
--------
T
V
S
Q
-----
R
F
G
L
L
-
L
E
S
Y
C
R
A
-------
C
G
------
M
---------
Y
L
K
H
L
N
--
R
Q
V
E
A
M
--
E
K
L
I
N
L
T
D
I
L
K
Q
E
-
K
-
K
--
D
----
E
----
T
Q
K
V
Q
M
K
F
L
V
E
Q
M
R
R
P
D
F
----
M
D
A
-
L
Q
G
F
L
S
P
L
-
N
P
-
A
H
Q
L
G
----
N
L
R
L
E
E
-
C
R
I
M
S
S
A
-
K
R
P
L
W
L
N
W
----------
E
N
P
----------
D
-
I
M
---------------------------------------------------
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-FN
S
H
T
L
H
Q
----
W
L
K
D
K
N
K
G
-------------
E
I
--
Y
D
-
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
-
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
K
F
G
Y
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
S
K
G
-
A
Q
E
C
-----------
T
K
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
-
G
-
S
G
M
P
--
E
L
Q
S
--
F
--
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
G
G
W
T
T
K
M
D
W
I
F
H
T
------------------
31
HHSearch
58.14
23%
-9
- C2 -
-
2X6K
1
?
A:
[48-693]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
R
Y
P
P
T
---
Y
V
L
S
S
E
E
Q
D
L
V
W
K
F
--------
R
F
Y
L
S
S
H
--
K
K
A
L
T
K
F
L
----------
K
CINWKL
E
D
E
V
T
Q
-
A
L
W
M
L
A
N
W
A
-
P
------
M
D
V
E
D
A
L
E
L
L
S
P
T
F
T
-
H
P
Q
V
R
K
Y
A
V
S
R
L
A
Q
-
A
-
P
D
E
D
L
L
L
Y
L
L
Q
L
V
Q
A
---
L
K
-----------------
Y
E
--
D
---
P
R
H
I
V
H
L
H
G
C
I
FP-----------------
A
N
L
C
T
F
L
I
Q
R
A
C
T
N
A
T
L
A
N
Y
---------
F
Y
W
Y
L
S
I
--
E
V
E
E
V
E
SVRK
Q
D
E
R
A
H
D
-----
M
Y
A
M
V
-
L
K
M
F
L
K
V
-------
L
E
------
N
--
G
N
F
N
L
R
G
I
F
Y
N
L
R
--
K
Q
R
R
F
I
--
D
E
L
V
K
L
V
K
L
V
A
K
E
-
P
-
G
N
R
N
----
K
----
K
T
E
----
K
F
Q
K
L
L
A
E
Q
D
M
F
K
VN
F
T
N
-
F
E
P
I
P
F
P
L
-
D
P
-
E
I
Y
I
T
----
K
I
V
P
M
R
-
T
S
L
F
K
S
A
-
L
M
P
A
K
L
T
F
----------
V
T
S
----------
I
---------------------------------------------------------
A
H
H
E
Y
A
A
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
M
I
T
L
M
D
K
L
L
R
R
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
S
K
H
G
F
L
Q
Y
V
D
S
-
C
T
V
A
E
V
L
A
R
E
---
G
N
I
H
N
----
F
F
R
K
H
H
P
C
------
D
N
--
G
PY
G
I
--
S
A
-
E
V
M
D
T
Y
I
K
S
C
A
G
Y
C
V
I
T
Y
L
L
G
V
G
D
R
H
L
D
N
L
L
L
T
T
-
N
G
K
L
F
H
I
D
F
G
Y
I
L
G
R
D
P
K
-----
P
M
P
P
P
M
K
L
S
K
E
M
V
E
A
M
G
G
I
-----------------
S
S
E
H
H
H
E
F
R
K
Q
C
Y
T
A
Y
L
H
L
R
R
H
A
N
V
M
L
N
L
F
S
L
M
V
-
D
-
A
T
V
P
--
D
I
A
L
--
E
P
D
K
A
V
K
K
V
E
E
N
L
Q
L
G
L
T
D
E
E
A
V
Q
H
L
Q
S
L
L
D
V
S
I
-
T
A
V
M
P
A
L
V
E
Q
I
H
R
F
T
Q
Y
--------------
2
PsiBlast_PDB
57.90
28%
-18
- C2 -
-
5C4G
1
PI4KB_HUMAN
E:
[40-512]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
Y
I
G
N
R
L
F
C
-
F
-
R
N
E
D
V
D
F
Y
L
P
Q
L
L
N
M
YIH
M
D
-----------------
E
D
--
V
---
G
-----------------------------
D
A
I
K
P
Y
I
V
H
R
C
R
Q
S
I
N
F
S
L
Q
CALLLGAYS----------
S
R
G
T
--------
K
L
R
K
LILS--------------------------------------------
R
LA
P
E
R
E
F
I
--
K
S
L
M
A
I
G
K
R
L
A
T
L
-
P
-
T
--
K
----
E
----
Q
K
T
----
Q
R
L
I
S
E
L
S
L
L
N
H
K
--
L
P
A
---
R
V
W
L
P
T
-
A
G
-
F
D
H
H
V
----
V
R
V
P
H
T
Q
A
V
V
L
N
S
K
D
K
A
P
Y
L
I
Y
V
EVLECENFDT
T
S
V
----------
P
A
R
I
P
E
-------
D
P
S
A
V
A
L
K
E
--
P
-----------
W
Q
EKVRRIRE
G
S
P
Y
-
G
H
L
-
P
N
W
R
--
L
L
S
V
I
V
K
C
G
D
D
L
R
Q
E
L
L
A
F
Q
V
L
K
Q
L
Q
S
I
W
E
Q
E
R
V
P
L
W
I
K
P
Y
K
I
L
V
I
S
A
D
S
G
M
I
E
P
V
V
N
A
V
S
I
H
Q
V
K
K
Q
S
--
Q
L
S
L
L
D
----
Y
F
L
Q
E
H
G
S
------
Y
T
--
T
--
E
A
--
F
L
-
S
A
Q
R
N
F
V
Q
S
C
A
G
Y
C
L
V
C
Y
L
L
Q
V
K
D
R
H
N
G
N
I
L
L
D
A
-
E
G
H
I
I
H
I
D
F
G
F
I
L
S
S
S
P
------------
K
L
T
T
E
F
V
D
V
M
G
G
-----------------
L
D
G
D
M
F
N
Y
Y
K
M
L
M
L
Q
G
L
I
A
A
R
K
H
M
D
K
V
V
Q
I
V
E
I
M
Q
-
Q
G
S
Q
L
P
--
C
F
H
G
--
S
--
S
T
I
R
N
L
K
E
R
F
H
M
S
M
T
E
-----------------------------------------------
3
PsiBlast_PDB
56.97
28%
-16
- C2 -
-
5EUQ
2
PI4KB_BOVIN (first)
E:
[40-512]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
Y
I
G
N
R
L
F
C
-
F
-
R
N
E
D
V
D
F
Y
L
P
Q
L
L
N
M
YIH
M
D
-----------------
E
D
--
V
---
G
-----------------------------
D
A
I
K
P
Y
I
V
H
R
C
R
Q
S
I
N
F
S
L
Q
CALLLGAYS----------
S
R
G
T
--------
K
L
R
K
LILS--------------------------------------------
R
LA
P
E
R
E
F
I
--
K
S
L
M
A
I
G
K
R
L
A
T
L
-
P
-
T
--
K
----
E
----
Q
K
T
----
Q
R
L
I
S
E
L
S
L
L
N
H
K
--
L
P
A
---
R
V
W
L
P
T
-
A
G
-
F
D
H
H
V
----
V
R
V
P
H
T
Q
A
V
V
L
N
S
K
D
K
A
P
Y
L
I
Y
V
EVLECENFDT
T
S
V
----------
P
A
R
I
P
---------
P
S
A
V
A
L
K
E
--
P
-----------
W
Q
EKVRRIRE
G
S
P
Y
-
G
H
L
-
P
N
W
R
--
L
L
S
V
I
V
K
C
G
D
D
L
R
Q
E
L
L
A
F
Q
V
L
K
Q
L
Q
S
I
W
E
Q
E
R
V
P
L
W
I
K
P
Y
K
I
L
V
I
S
A
D
S
G
M
I
E
P
V
V
N
A
V
S
I
H
Q
V
K
K
Q
S
--
Q
L
S
L
L
D
----
Y
F
L
Q
E
H
G
S
------
Y
T
--
T
--
E
A
--
F
L
-
S
A
Q
R
N
F
V
Q
S
C
A
G
Y
C
L
V
C
Y
L
L
Q
V
K
D
R
H
N
G
N
I
L
L
D
A
-
E
G
H
I
I
H
I
D
F
G
F
I
L
S
S
S
P
------------
K
L
T
T
E
F
V
D
V
M
G
G
-----------------
L
D
G
D
M
F
N
Y
Y
K
M
L
M
L
Q
G
L
I
A
A
R
K
H
M
D
K
V
V
Q
I
V
E
I
M
Q
-
Q
G
S
Q
L
P
--
C
F
H
G
--
S
--
S
T
I
R
N
L
K
E
R
F
H
M
S
M
T
E
-----------------------------------------------
18
PsiBlast_PDB
56.25
26%
-12
- C2 -
-
4FJY
1
PK3CG_HUMAN
A:
[485-946]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
Q
L
L
D
C
N
F
S
D
-
E
N
V
R
A
I
A
V
Q
K
L
E
S
-
L
-
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
---
V
K
-----------------
F
E
PY
H
---
D
-----------------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
---------
L
F
W
F
L
R
S
--
E
I
A
Q
S
R
-------
H
Y
Q
Q
-----
R
F
A
V
I
L
E
A
Y
L
R
G
C
G
T
A
M
L
H
D
F
T
------
Q
--
Q
------
V
Q
V
I
E
M
--
L
Q
K
V
T
L
--
D
I
-
K
S
L
S
A
E
-----
D
V
S
--
S
----
Q
----
V
I
S
----
Q
L
K
Q
K
L
E
N
L
Q
N
S
Q
--
L
P
E
---
S
F
R
V
P
Y
-
D
P
-
G
L
K
A
G
----
A
L
A
I
E
K
-
C
K
V
M
A
S
K
K
K
-
P
L
W
L
E
F
----------
K
C
A
----------
D
-
P
T
A
---------------------------------------------------
L
S
N
E
T
I
-
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
--
V
G
N
T
G
A
----
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
--
E
--
E
K
--
F
Q
-
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
-
T
G
N
L
F
H
I
D
F
G
H
I
------------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
--
T
S
G
K
K
T
------------
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
-
M
-
T
G
M
P
--
Q
L
T
S
--
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
-
D
K
G
W
T
V
Q
F
N
W
F
L
-------------------
20
PsiBlast_PDB
55.82
26%
-7
- C2 -
-
1E8Z
1
PK3CG_HUMAN
A:
[485-950]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
Q
L
L
D
C
N
F
S
D
-
E
N
V
R
A
I
A
V
Q
K
L
E
S
-
L
-
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
---
V
K
-----------------
F
E
PY
H
---
D
-----------------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
---------
L
F
W
F
L
R
S
--
E
I
A
Q
S
R
-------
H
Y
Q
Q
-----
R
F
A
V
I
L
E
A
Y
L
R
G
C
G
T
A
M
L
H
D
F
T
------
Q
--
Q
------
V
Q
V
I
E
M
--
L
Q
K
V
T
L
--
D
I
-
K
S
L
S
A
E
--
K
Y
-
D
V
S
--
S
----
Q
----
V
I
S
----
Q
L
K
Q
K
L
E
N
L
Q
N
S
Q
--
L
P
E
---
S
F
R
V
P
Y
-
D
P
-
G
L
K
A
G
----
A
L
A
I
E
K
-
C
K
V
M
A
S
K
K
K
-
P
L
W
L
E
F
----------
K
C
A
----------
D
-
P
T
A
---------------------------------------------------
L
S
N
E
T
I
-
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
--
V
G
N
T
G
-----
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
--
E
--
E
K
--
F
Q
-
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
-
T
G
N
L
F
H
I
D
F
G
H
-------------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
--
T
S
G
K
K
T
------------
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
-
M
-
T
G
M
P
--
Q
L
T
S
--
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
-
D
K
G
W
T
V
Q
F
N
W
F
L
H
L
V
L
---------------
19
PsiBlast_PDB
55.66
26%
-7
- C2 -
-
1E8Y
-
PK3CG_HUMAN
A:
[627-1092]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
Q
L
L
D
C
N
F
S
D
-
E
N
V
R
A
I
A
V
Q
K
L
E
S
-
L
-
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
---
V
K
-----------------
F
E
PY
H
---
D
-----------------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
---------
L
F
W
F
L
R
S
--
E
I
A
Q
S
R
-------
H
Y
Q
Q
-----
R
F
A
V
I
L
E
A
Y
L
R
G
C
G
T
A
M
L
H
D
F
T
------
Q
--
Q
------
V
Q
V
I
E
M
--
L
Q
K
V
T
L
--
D
I
-
K
S
L
S
A
E
--
K
Y
-
D
V
S
--
S
----
Q
----
V
I
S
----
Q
L
K
Q
K
L
E
N
L
Q
N
S
Q
--
L
P
E
---
S
F
R
V
P
Y
-
D
P
-
G
L
K
A
G
----
A
L
A
I
E
K
-
C
K
V
M
A
S
K
K
K
-
P
L
W
L
E
F
----------
K
C
A
----------
D
-
P
T
A
---------------------------------------------------
L
S
N
E
T
I
-
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
--
V
G
N
T
G
-----
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
--
E
--
E
K
--
F
Q
-
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
-
T
G
N
L
F
H
I
D
F
G
H
-------------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
--
T
S
G
K
K
T
------------
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
-
M
-
T
G
M
P
--
Q
L
T
S
--
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
-
D
K
G
W
T
V
Q
F
N
W
F
L
H
L
V
L
---------------
14
PsiBlast_PDB
55.49
26%
-5
- C2 -
-
4ANW
1
PK3CG_HUMAN
A:
[489-949]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
Q
L
L
D
C
N
F
S
D
-
E
N
V
R
A
I
A
V
Q
K
L
E
S
-
L
-
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
---
V
K
-----------------
F
E
PY
H
---
D
-----------------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
---------
L
F
W
F
L
R
S
--
E
I
A
Q
S
R
-------
H
Y
Q
Q
-----
R
F
A
V
I
L
E
A
Y
L
R
G
C
G
T
A
M
L
H
D
F
T
------
Q
--
Q
------
V
Q
V
I
E
M
--
L
Q
K
V
T
L
--
D
I
-
K
S
L
S
A
E
--
K
Y
-
D
V
S
--
S
----
Q
----
V
I
S
----
Q
L
K
Q
K
L
E
N
L
Q
N
S
Q
--
L
P
E
---
S
F
R
V
P
Y
-
D
P
-
G
L
K
A
G
----
A
L
A
I
E
K
-
C
K
V
M
A
S
K
K
K
-
P
L
W
L
E
F
----------
K
C
A
----------
D
-
P
T
A
---------------------------------------------------
L
S
N
E
T
I
-
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
--
V
G
N
T
G
A
----
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
--
E
--
E
K
--
F
Q
-
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
-
T
G
N
L
F
H
I
D
F
G
H
I
------------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
--
T
S
G
K
K
T
------------
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
-
M
-
T
G
M
P
--
Q
L
T
S
--
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
-
D
K
G
W
T
V
Q
F
N
W
F
--------------------
15
PsiBlast_PDB
55.42
26%
-11
- C2 -
-
5G2N
1
PK3CG_HUMAN
A:
[489-953]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
Q
L
L
D
C
N
F
S
D
-
E
N
V
R
A
I
A
V
Q
K
L
E
S
-
L
-
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
---
V
K
-----------------
F
E
PY
H
---
D
-----------------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
---------
L
F
W
F
L
R
S
--
E
I
A
Q
S
R
-------
H
Y
Q
Q
-----
R
F
A
V
I
L
E
A
Y
L
R
G
C
G
T
A
M
L
H
D
F
T
------
Q
--
Q
------
V
Q
V
I
E
M
--
L
Q
K
V
T
L
--
D
I
-
K
S
L
S
A
E
--
K
Y
-
D
V
S
--
S
----
Q
----
V
I
S
----
Q
L
K
Q
K
L
E
N
L
Q
N
S
Q
--
L
P
E
---
S
F
R
V
P
Y
-
D
P
-
G
L
K
A
G
----
A
L
A
I
E
K
-
C
K
V
M
A
S
K
K
K
-
P
L
W
L
E
F
----------
K
C
A
----------
D
-
P
T
A
---------------------------------------------------
L
S
N
E
T
I
-
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
--------
T
G
A
----
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
--
E
--
E
K
--
F
Q
-
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
-
T
G
N
L
F
H
I
D
F
G
H
I
------------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
--
T
S
G
K
K
T
------------
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
-
M
-
T
G
M
P
------------
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
-
D
K
G
W
T
V
Q
F
N
W
F
L
H
L
V
----------------
17
PsiBlast_PDB
55.39
26%
-11
- C2 -
-
3QK0
1
PK3CG_HUMAN
A:
[485-950]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
Q
L
L
D
C
N
F
S
D
-
E
N
V
R
A
I
A
V
Q
K
L
E
S
-
L
-
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
---
V
K
-----------------
F
E
PY
H
---
D
-----------------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
---------
L
F
W
F
L
R
S
--
E
I
A
Q
S
R
-------
H
Y
Q
Q
-----
R
F
A
V
I
L
E
A
Y
L
R
G
C
G
T
A
M
L
H
D
F
T
------
Q
--
Q
------
V
Q
V
I
E
M
--
L
Q
K
V
T
L
--
D
I
-
K
S
L
S
-------
D
V
S
--
S
----
Q
----
V
I
S
----
Q
L
K
Q
K
L
E
N
L
Q
N
S
Q
--
L
P
E
---
S
F
R
V
P
Y
-
D
P
-
G
L
K
A
G
----
A
L
A
I
E
K
-
C
K
V
M
A
S
K
K
K
-
P
L
W
L
E
F
----------
K
C
A
----------
D
-
P
T
A
---------------------------------------------------
L
S
N
E
T
I
-
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
--
V
G
N
T
G
A
----
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
--
E
--
E
K
--
F
Q
-
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
-
T
G
N
L
F
H
I
D
F
G
H
I
------------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
--
T
S
G
K
K
T
------------
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
-
M
-
T
G
M
P
--
Q
L
T
S
--
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
-
D
K
G
W
T
V
Q
F
N
W
F
L
H
L
V
L
---------------
1
PsiBlast_PDB
55.24
28%
-12
- C2 -
-
5C46
-
PI4KB_HUMAN
E:
[40-512]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
Y
I
G
N
R
L
F
C
-
F
-
R
N
E
D
V
D
F
Y
L
P
Q
L
L
N
M
YIH
M
D
-----------------
E
D
--
V
---
G
-----------------------------
D
A
I
K
P
Y
I
V
H
R
C
R
Q
S
I
N
F
S
L
Q
CALLLGAYS----------
S
R
G
T
--------
K
L
R
K
LILSD-------------------------------------------
R
LA
P
E
R
E
F
I
--
K
S
L
M
A
I
G
K
R
L
A
T
L
-
P
-
T
--
K
----
E
----
Q
K
T
----
Q
R
L
I
S
E
L
S
L
L
N
H
K
--
L
P
A
---
R
V
W
L
P
T
-
A
G
-
F
D
H
H
V
----
V
R
V
P
H
T
Q
A
V
V
L
N
S
K
D
K
A
P
Y
L
I
Y
V
EVLECENFDT
T
S
V
----------
P
A
R
I
P
--------
D
P
S
A
V
A
L
K
E
--
P
-----------
W
Q
EKVRRIRE
G
S
P
Y
-
G
H
L
-
P
N
W
R
--
L
L
S
V
I
V
K
C
G
D
D
L
R
Q
E
L
L
A
F
Q
V
L
K
Q
L
Q
S
I
W
E
Q
E
R
V
P
L
W
I
K
P
Y
K
I
L
V
I
S
A
D
S
G
M
I
E
P
V
V
N
A
V
S
I
H
Q
V
K
K
Q
S
--
Q
L
S
L
L
D
----
Y
F
L
Q
E
H
G
S
------
Y
T
--
T
--
E
A
--
F
L
-
S
A
Q
R
N
F
V
Q
S
C
A
G
Y
C
L
V
C
Y
L
L
Q
V
K
D
R
H
N
G
N
I
L
L
D
A
-
E
G
H
I
I
H
I
D
F
G
F
I
L
S
S
S
P
---------
S
A
F
K
L
T
T
E
F
V
D
V
M
G
G
-----------------
L
D
G
D
M
F
N
Y
Y
K
M
L
M
L
Q
G
L
I
A
A
R
K
H
M
D
K
V
V
Q
I
V
E
I
M
Q
-
Q
G
S
Q
L
P
--
C
F
H
G
--
S
--
S
T
I
R
N
L
K
E
R
F
H
M
S
M
T
E
-----------------------------------------------
29
HHSearch
54.71
23%
-6
- C2 -
-
5DFZ
-
VPS34_YEAST
C:
[318-872]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
T
A
H
E
K
G
S
I
W
K
Y
RYYLMNN-
K
K
A
L
T
K
L
--
L
Q
S
T
N
L
R
E
----------
E
-------
S
E
R
V
E
V
L
E
-
L
M
D
S
W
A
-
E
------
I
D
I
D
D
A
L
E
L
L
G
S
T
F
K
-
N
L
S
V
R
S
Y
A
V
N
R
L
K
K
-
A
-
S
D
K
E
L
E
L
Y
L
L
Q
L
V
E
A
---
V
C
-----------------
F
E
--
N
---
L
STFSDKSNSEFTIVDAVS------------
P
L
A
E
F
L
I
R
R
A
L
V
N
P
R
L
G
S
F
---------
F
Y
W
Y
L
K
S
--
E
S
E
D
K
P
----------------
Y
L
D
Q
I
-
L
S
S
F
W
S
R
-------
L
D
------
K
--
K
------
S
R
N
I
L
N
--
D
Q
V
R
L
I
--
N
V
L
R
E
C
C
E
T
I
K
R
L
-
K
-
D
--
T
TA--
K
----
K
M
E
----
L
L
V
H
L
L
E
T
K
-
V
R
P
--
L
V
K
-
V
R
P
I
A
L
P
L
-
D
P
-
D
V
L
I
C
----
D
V
C
P
E
T
-
S
K
V
F
K
S
S
-
L
S
P
L
K
I
T
F
----------
K
T
T
--------------------------------------------------------------------
L
N
Q
P
Y
H
L
M
F
K
V
G
D
D
L
R
Q
D
Q
L
V
V
Q
I
I
S
L
M
N
E
L
L
K
N
E
N
V
D
L
K
L
T
P
Y
K
I
L
A
T
G
P
Q
E
G
A
I
E
F
I
P
N
-
D
T
L
A
S
I
L
S
K
Y
---
H
G
I
L
G
----
Y
L
K
L
H
Y
P
D
------
E
N
--
A
TL
G
V
--
Q
G
-
W
V
L
D
N
F
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
V
T
P
-
D
G
H
F
F
H
A
D
F
G
Y
I
L
G
Q
D
P
K
-----
P
F
P
P
L
M
K
L
P
P
Q
I
I
E
A
F
G
G
A
-----------------
E
S
S
N
Y
D
K
F
R
S
Y
C
F
V
A
Y
S
I
L
R
R
N
A
G
L
I
L
N
L
F
E
L
M
K
-
T
-
S
N
I
P
--
D
I
R
I
--
D
PN
G
A
I
L
R
V
R
E
R
F
N
L
N
M
S
E
E
D
A
T
V
H
F
Q
N
L
I
N
D
S
V
-
N
A
L
L
P
I
V
I
D
H
L
H
N
L
A
Q
Y
--------------