@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_29_2600: (2018-03-11 )
MSRYQCSLCQLETLENDLNFCVCCRAAVCAKCTLACYPNRKSVGLCVRCTPPDYGFACGRCRRHISYGDIEFFCDMCAVPICFTCVASGTSFECGQLKCSLCCECPMSQAPRNLVVRHEVDDAMLRQLPIPLVSSATPLAAPPPQARAAAAAVAATKSTKYRKLFGREKLGEGAQGVVYKCHTEENEVVVVKEMVFNDTDVTAFEAQARQVERMRQLNHPHLIRYLDVSVQKDPLRICVVMPFYSEGDLKKFIERQRKPVTEVKLCSIVLQIAGALNYLHRQEPPLVHRDIKPENILLLNHEEQVLLMDLDLCRTVDVTASVIKRRELSPTYEYRAPELEKSHGDTKADVFSLGVVMFVLATLPDFPCVRTDSGEMLVFSASKWSPSSLKRAIQREIRRVQRYTYSEEFIRLVVAMLVHQPAARPTSGAVIYRLQKIMEQRLMEGKE
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.------.--------.....190.......200.....--.-.210.....-..-220......--.230-........240.-......250.....---------------..--------260....-...270.......280.......290.......300.---......310.......320-.----......330......--.340.--.......350.......360-.--..-.....370......--..380...-....390...----.-...400--------.......410.......420.-......430.......440.....----------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSR
Y
Q
CSL
C
Q
L
E
T
L
ENDL
N
F
C
V
C
C
R
A
A
V
C
A
K
C
T
L
A
CYPNRKSV
G
L
C
V
R
CTPPDYG
F
A
C
G
R
C
R
RHISY
G
D
I
E
F
F
C
D
MC
A
V
P
I
C
F
T
C
VASGTSFECG
Q
L
K
C
S
L
CCECPMSQAPR
N
L
V
V
R
HEV
D
D
A
M
L
R
QLPIPLVSSATPLAAPPP
Q
A
R
A
A
A
A
A
V
AATKS
T
K
Y
R
K
L
FG
R
E
KLGEGAQ
G
V
V
Y
K
C
HT------E--------EN
E
V
V
V
V
K
E
MVFNDTDV
T
A
F
E
A
Q
--
A
-
R
Q
V
E
R
M
R
QL-N
H
-
P
H
L
I
R
Y
L
DV--SVQ--KD
P
L
R
I
C
V
V
MPF-YSE
G
D
L
K
K
F
I
E
R
QR---------------KP--------
V
T
E
V
K
L
C
-
S
I
V
L
Q
I
A
G
A
L
N
Y
L
HRQEPPLVHRDIKPE
N
I
L
L
LNHE
E
---
Q
V
L
L
M
D
L
D
LCRT
V
D
V
T
A
S
V
-
I
----
K
RRELSPTYEYRAPE--LEK-S--HGDT
K
A
D
V
F
S
L
G
V
V
M
F
V
L
A
--T--LP-DFP
C
V
R-TDSG
E
M
L
--
V
F
SASKW
S
-
P
S
S
L
K
R
A
I
Q
R
----
E
-
I
R
R
V
Q
R
--------
Y
T
Y
S
E
E
F
I
R
L
V
V
A
M
L
VHQPAA-RPTS
G
A
V
I
Y
R
L
Q
K
I
M
E
Q
R
L
MEGKE----------------------------------------------------------------------
28
HHSearch
71.83
22%
-124
- C1 -
-
4HCU
1
A:
[12-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
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---------------
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--------
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---
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D
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------
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N
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E
V
V
----------------
E
D
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----
G
-
F
R
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Y
K
P
--------
R
L
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A
E
S
-----------------------------------------------------------------------------
34
HHSearch
68.93
22%
-120
- C1 -
-
3T9T
3
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
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E
I
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Q
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L
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G
Y
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------
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--------
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---
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--
A
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-
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R
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R
---------------
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--------
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-
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---
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--
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----
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A
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--
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--
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--
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-
K
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E
N
-
R
S
N
S
E
V
V
----------------
E
D
I
S
T
----
G
-
F
R
L
Y
K
P
--------
R
L
A
S
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H
V
Y
Q
I
M
N
H
C
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D
-
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A
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S
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L
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R
Q
L
A
E
I
A
E
S
-----------------------------------------------------------------------------
30
HHSearch
66.32
20%
-121
- C1 -
-
4Y95
4
?
A:
[9-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
--------
G
Q
Y
D
V
A
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M
I
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M
---
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--
I
-
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A
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M
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-
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-
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L
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G
V
--
C
T
K
----
Q
R
P
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F
I
I
T
E
Y
-
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
---------------
H
R
--------
F
Q
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Q
Q
L
L
-
E
M
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--
F
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-
Q
G
---
V
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--
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----
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--
V
L
M
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--
K
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M
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I
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--
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--
L
G
-
K
M
P
Y
E
R
-
F
T
N
S
E
T
----------------
A
E
H
I
A
Q
----
G
-
L
R
L
P
R
P
--------
H
L
A
S
E
R
V
Y
A
I
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Y
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C
W
H
E
K
A
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D
E
-----------------------------------------------------------------------------
25
HHSearch
63.04
20%
-119
- C1 -
-
5T18
1
A:
[9-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
--------
G
Q
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M
---
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L
R
E
---------------------------
F
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-
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----
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-
L
R
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--------
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-----------------------------------------------------------------------------
21
HHSearch
62.45
23%
-7
* C1 *
-
2PSQ
-
B:
[83-365]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
L
G
K
P
L
G
E
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C
F
G
Q
V
V
M
A
E
A
V
GIDP-
K
--------
E
A
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A
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M
L
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D
D
A
-
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PPGE-----------
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--------
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----
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-----------------------------------------------------------------------------
38
HHSearch
62.10
20%
-130
- C1 -
-
5P9J
1
A:
[21-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
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31
HHSearch
60.96
27%
22
- C1 -
-
4CKJ
16
A:
[25-313]
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HLKGR
A
--------
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KV-------------
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C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
-
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
R
----------------------------------------------------------------------------
40
HHSearch
60.92
26%
16
- C1 -
-
5AMN
7
A:
[27-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
HLKGR
A
--------
G
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
D
L
--
L
-
S
E
F
N
V
L
K
Q
V
-
N
H
-
P
H
V
I
K
L
Y
G
A
--
C
S
Q
--
D
--
G
P
L
L
L
I
V
E
Y
-
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
KVE------------
R
A
--------
L
T
M
G
D
L
I
-
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
--
L
V
H
R
D
L
A
A
R
N
I
L
V
A
E
-
G
R
---
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
-
V
----
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
--
S
L
F
-
D
H-
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
--
T
--
L
G
-
G
N
P
Y
P
G
-
I
P
P
E
R
L
----------------
F
N
L
L
K
T
----
G
-
H
R
M
E
R
P
--------
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
-
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
------------------------------------------------------------------------------
39
HHSearch
55.39
25%
-5
- C1 -
-
4AT5
2
A:
[17-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
NL-------------
K
I
L
V
A
V
K
T
L
K
D
A
S
--
D
N
A
R
K
D
F
--
H
-
R
E
A
E
L
L
T
N
L
-
Q
H
-
E
H
I
V
K
F
Y
G
V
--
C
V
E
--
G
--
D
P
L
I
M
V
F
E
Y
-
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
AE
G
N
P
P
---
T
E
--------
L
T
Q
S
Q
M
L
-
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
--
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
-
N
L
---
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
-
R
----
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
--
S
I
M
Y
R
--
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
--
T
--
Y
G
-
K
Q
P
W
Y
Q
-
L
S
N
N
E
V
----------------
I
E
C
I
T
Q
----
G
-
R
V
L
Q
R
P
--------
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
-
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
----------------------------------------------------------------------------
37
HHSearch
55.02
22%
1
- C1 -
-
1YVJ
3
A:
[12-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
DPLGD-
N
--------
T
G
A
L
V
A
V
K
Q
L
Q
H
S
G
P
--
D
Q
Q
R
D
F
--
Q
-
R
E
I
Q
I
L
K
A
L
-
H
S
-
D
F
I
V
K
Y
R
G
V
--
S
Y
G
--
P
G
R
P
E
L
R
L
V
M
E
Y
-
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
---------------
A
R
--------
L
D
A
S
R
L
L
-
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
--
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
-
E
A
---
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
----
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
--
S
L
S
-
D
N-
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
--
T
--
Y
C
-
D
K
S
C
S
P
-
S
A
E
F
L
R
M
--
M
G
C
E
R
D
V
P
A
L
C
R
L
L
E
L
L
E
E
----
G
-
Q
R
L
P
A
P
--------
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
-
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
-----------------------------------------------------------------------------
29
HHSearch
54.76
24%
-11
- C1 -
-
5O2C
4
WNK3_HUMAN
A:
[30-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
------
T
E-------
T
W
V
E
V
A
W
C
E
L
Q
D
R
K
L
T
K
A
E
Q
Q
R
F
--
K
-
E
E
A
E
M
L
K
G
L
-
Q
H
-
P
N
I
V
R
F
Y
D
S
--
W
E
S
I
L
K
G
K
K
C
I
V
L
V
T
E
L
-
M
T
S
G
T
L
K
T
Y
L
K
R
F
----------------
K
V
--------
M
K
P
K
V
L
R
-
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
G
---
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
---------
A
K
S
V
I
G
T
P
E
F
M
A
P
E
--
M
Y
E
-
E
--
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
--
T
--
S
E
--
Y
P
Y
S
E
-
C
Q
N
A
A
Q
I
---------------
Y
R
K
V
T
S
----
G
I
K
P
A
S
F
N
--------
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
-
R
L
S
I
R
D
L
L
N
H
------------------------------------------------------------------------------------
5
PsiBlast_PDB
53.08
28%
-2
- C1 -
-
5O1V
9
WNK3_HUMAN
A:
[5-252]
----------------------------------------------------------------------------------------------------------------------------------------------------
E
M
K
A
V
A
T
S
P
S
G
R
F
L
K
-
F
D
I
E
-
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
------
T
--------
E
T
W
V
E
V
A
-
W
C
E
L
Q
D
R
K
L
T
K
A
E
Q
Q
R
F
K
-
E
E
A
E
M
L
K
G
L
-
Q
H
-
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
--
K
G
K
K
C
I
V
L
V
T
E
L
-
M
T
S
G
T
L
K
T
Y
L
K
R
F
K
VM-------------
K
P
--------
K
V
L
R
S
W
C
-
R
---
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
G
---
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
---------
K
S
V
I
G
T
P
E
F
M
A
P
E
--
M
Y
E
-
E
--
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
--
T
---
S
-
E
Y
P
Y
S
E
C
Q
N
A
A
Q
I
Y
--
R
K
V
T
S
G
I
K
-
P
A
S
F
N
K
V
T
D
P
----
E
-
V
K
E
I
------------------------------------------------------------------------------------------------------------------------------
49
Fugue
53.04
18%
-4
- C1 -
-
4EUT
1
TBK1_HUMAN
A:
[2-387]
----------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
------
K
--------
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
L
R
P
V
D
V
Q
--
M
-
R
E
F
E
V
L
K
K
L
-
N
H
-
K
N
I
V
K
L
F
A
I
--
E
E
E
--
T
T
T
R
H
K
V
L
I
M
E
F
-
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
---------------
N
A
YG------
L
P
E
S
E
F
L
-
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
--
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
Q
F
-
V
SLYG
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
--
D
H
Q
-
K
--
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
--
T
GS
L
P
-
F
R
P
F
E
G
-
P
R
R
N
K
E
V
--
M
Y
K
I
I
T
G
K
-
P
S
G
A
I
S
G
V
Q
K
AEN
G
P
-
I
D
W
S
G
D
MPVSCSLS
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
-
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
LQQM
T
A
H
K
I
Y
I
H
SYNT
A
T
I
F
H
E
L
V
Y
K
Q
T
KIISSN
Q
E
L
I
Y
EG
R
R
L
V
L
E
PGRLAQHFPKTTEE
N
P
I
F
V
V
S
RE
22
HHSearch
52.55
20%
-31
- C1 -
-
3BKB
7
A:
[117-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
------
R
A-------
D
N
T
L
V
A
V
K
S
C
R
E
T
L
-
P
P
D
L
K
A
K
F
--
L
-
Q
E
A
R
I
L
K
Q
Y
-
S
H
-
P
N
I
V
R
L
I
G
V
--
C
T
Q
--
K
--
Q
P
I
Y
I
V
M
E
L
-
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
---------------
A
R
--------
L
R
V
K
T
L
L
-
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
-
K
N
---
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
-
A
----
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
--
A
L
N
Y
G
--
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
--
S
--
L
G
-
A
S
P
Y
P
N
-
L
S
N
Q
Q
T
----------------
R
E
F
V
E
K
----
G
-
G
R
L
P
C
P
--------
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
-
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
-----------------------------------------------------------------------------
35
HHSearch
51.74
22%
2
- C1 -
-
3TT0
1
FGFR1_HUMAN
A:
[70-354]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
------
I
GLDKDKPN
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
D
L
--
I
-
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
L
L
G
A
--
C
T
Q
--
D
--
G
P
L
Y
V
I
V
E
Y
-
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PPGLEYSYNPSHNP
E
E
Q
--------
L
S
S
K
D
L
V
-
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
-
D
N
---
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
-
K
----
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
--
A
L
F
-
D
R-
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
--
T
--
L
G
-
G
S
P
Y
P
G
-
V
P
V
E
E
L
----------------
F
K
L
L
K
E
----
G
-
H
R
M
D
K
P
--------
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
-
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
----------------------------------------------------------------------------
51
Fugue
51.03
24%
-
- C1 -
-
3H4J
-
SNF1_SCHPO
B:
[27-356]
-----------------------------
S
K
R
H
I
G
P
Y
I
I
R
E
T
L
G
E
G
-------------------
S
F
G
K
V
K
L
A
T
H
---------------------------------
Y
K
T
Q
Q
K
V
A
L
K
F
I
S
R
Q
L
L
K
K
S
D
M
H
---------------------------------------------------------------------------------------
M
R
V
--
E
-
R
E
I
S
Y
L
K
L
L
-
R
H
-
P
H
I
I
K
L
Y
D
V
--
I
T
----
T
P
T
D
I
V
M
V
I
E
--
Y
A
G
G
E
L
F
D
Y
I
V
E
K
K
---------------
R
---------
M
T
E
D
E
G
R
-
R
F
F
Q
Q
I
I
C
A
I
E
Y
C
H
R
H
K
I
--
V
H
R
D
L
K
P
E
N
-
L
L
L
D
D
N
L
---
N
V
K
I
A
D
F
G
L
S
N
I
M
T
-
D
G
N
F
-
L
----
K
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
N
G
K
-
L
--
Y
A
G
P
E
V
D
V
W
S
C
G
I
V
L
Y
V
M
L
VG
R
--
L
P
F
D
D
E
F
I
P
-
N
L
F
K
K
V
N
SC
V
Y
V
M
P
D
F
L
-
S
P
G
A
Q
S
L
I
R
R
----
M
-
I
V
A
D
P
M
--------
Q
R
I
T
I
Q
E
I
R
R
D
P
W
F
N
V
N
L
P
D
Y
L
R
P
M
E
E
V
Q
G
S
Y
A
D
S
R
I
V
S
K
L
G
E
A
M
G
FSEDYIVEALRSDENNEVKEAYNLLHENQVIQEKLEHHH-------------------------------
23
HHSearch
50.90
20%
-30
- C1 -
-
3CBL
3
A:
[118-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
------
R
A-------
D
N
T
L
V
A
V
K
S
C
R
E
T
L
-
P
P
D
L
K
A
K
F
--
L
-
Q
E
A
R
I
L
K
Q
Y
-
S
H
-
P
N
I
V
R
L
I
G
V
--
C
T
Q
--
K
--
Q
P
I
Y
I
V
M
E
L
-
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
---------------
A
R
--------
L
R
V
K
T
L
L
-
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
-
K
N
---
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
-
A
----
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
--
A
L
N
Y
G
--
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
--
S
--
L
G
-
A
S
P
Y
P
N
-
L
S
N
Q
Q
T
----------------
R
E
F
V
E
K
----
G
-
G
R
L
P
C
P
--------
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
-
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
-----------------------------------------------------------------------------
26
HHSearch
50.31
21%
8
- C1 -
-
4ASE
1
A:
[66-348]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
GIDKT
A
--------
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
-
H
S
E
H
R
A
L
--
M
-
S
E
L
K
I
L
I
H
I
-
G
H
H
L
N
V
V
N
L
L
G
A
--
C
T
K
--
P
G
-
G
P
L
M
V
I
V
E
F
-
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
---------------
N
E
FVPYYKDF
L
T
L
E
H
L
I
-
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
--
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
-
K
N
---
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
-
V
----
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
--
T
I
F
D
R
--
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
--
S
--
L
G
-
A
S
P
Y
P
G
-
V
K
I
D
E
E
F
---------------
C
R
R
L
K
E
----
G
-
T
R
M
R
A
P
--------
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
-
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
-----------------------------------------------------------------------------
9
PsiBlast_PDB
49.60
27%
-61
- C1 -
-
3NIZ
1
?
A:
[22-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Q
K
L
---
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
------
S
--------
Q
G
R
I
V
A
L
K
R
I
R
------
G
I
P
S
T
A
--
I
-
R
E
I
S
L
L
K
E
L
-
H
H
-
P
N
I
V
S
L
I
D
V
--
I
H
S
--
E
R
----
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
N
K
---------------
T
G
--------
L
Q
D
S
Q
I
K
-
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
--
I
L
H
R
D
L
K
P
Q
N
-
L
L
I
N
S
D
G
---
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
--------
H
E
V
V
--
T
L
W
Y
R
A
P
D
V
L
M
G
S
-
K
--
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
--
T
G-
K
P
-
L
F
P
G
V
T
-
D
D
D
Q
L
P
K
--
I
F
S
--------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
48.59
28%
5
- C1 -
-
5O21
8
WNK3_HUMAN
A:
[6-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
V
A
T
S
P
S
G
R
F
L
K
-
F
D
I
E
-
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
------
T
--------
E
T
W
V
E
V
A
-
W
C
E
L
Q
D
R
K
L
T
K
A
E
Q
Q
R
F
K
-
E
E
A
E
M
L
K
G
L
-
Q
H
-
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
--
K
G
K
K
C
I
V
L
V
T
E
L
-
M
T
S
G
T
L
K
T
Y
L
K
R
F
K
VM-------------
K
P
--------
K
V
L
R
S
W
C
-
R
---
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
G
---
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
---------
K
S
V
I
G
T
P
E
F
M
A
P
E
--
M
Y
E
-
E
--
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
--
T
---
S
-
E
Y
P
Y
S
E
C
Q
N
A
A
Q
I
Y
--
R
K
V
T
S
G
I
K
-
P
A
S
F
N
K
V
T
D
P
----
E
-
V
K
E
I
------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
47.80
33%
-14
- C1 -
-
4EON
1
CDK2_HUMAN
A:
[10-200]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
------
K
L-------
T
G
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
G
V
P
S
T
--
A
I
R
E
I
S
L
L
K
E
L
-
N
H
-
P
N
I
V
K
L
L
D
V
--
I
H
T
--
E
N
--
K
L
Y
L
V
F
E
F
-
L
S
M
-
D
L
K
K
F
M
D
A
S
A
---------------
L
T
--------
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
E
N
-
L
L
I
N
T
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
----
T
H
E
V
V
--
T
L
W
Y
R
A
P
E
--
I
L
L
-
G
CK
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
--
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
41.76
32%
-12
- C1 -
-
1OIT
1
CDK2_HUMAN
A:
[8-198]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
------
K
L--------
G
E
V
V
A
L
K
K
I
------------
T
--
A
I
R
E
I
S
L
L
K
E
L
-
N
H
-
P
N
I
V
K
L
L
D
V
--
I
H
T
--
E
N
--
K
L
Y
L
V
F
E
F
-
L
H
Q
-
D
L
K
K
F
M
D
A
S
A
---------------
L
T
--------
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
-
L
L
I
N
T
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
----------------
V
V
--
T
L
W
Y
R
A
P
E
--
I
L
L
-
G
CK
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
--
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------