@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_29_2830: (2018-03-11 )
MSLRSAMHASDVDDAGRALQSTQRSIVSISRLTNEMSEVRAMSEGSFGVVKCYRHDFDKLEYAVKQTKRPICGESNLQQQLQEIYALSSFPHRHIVRYFDGWVEDRAVFVRLEKLDDCMASLPPPVSESVLTAMLHQTSTALYELHSHDVVHMDVKPENILRRQLDADTFIFKLCDFGLARPLNGKDSVTGEHFLGLNDDDGDRRYMSPELLKNLHDVVGPPADMYALGKSCEAMMTATEDPSNTSARHLESYSPAFIALIESMLCEDPARRPSAFQVVQATLPERLLSDGGLLELQRRIDAIRCEISDLDASDNDVMSSPRT
Atome Classification :
(20 SA)
.........10........20.....-...30........40.......-.50........60........70.-.------......80.-......-.90.-........100.......110------.-----.....-.--------120---.------......130--------.........140.......150.......160-........170.........180.......190.......200.......210...----....220.......230....------------.-----.--.-----240...--------------.-----------------..-----------.250--------.-----------..-......260.--------......270.......280---.........290.......300.......310.......320.---------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
L
R
S
AMHAS
D
V
D
D
A
G
R
A
L
Q
S
T
Q
R
S
I
-
V
S
I
S
R
L
T
N
E
M
S
E
V
R
A
MSEGS
F
G
-
V
V
K
C
Y
RH
D
F
D
K
L
E
Y
A
V
K
QTKRPIC-G------
E
S
N
L
Q
Q
Q
L
Q
-
E
I
Y
A
LS-SF-
P
-
H
R
H
I
V
R
Y
F
D
G
W
VEDR
A
V
F
V
R
L
------
E
-----
K
L
D
D
C
-
M
--------ASL---P------PP
V
S
E
S
V
----------
L
T
A
M
L
H
Q
T
S
T
A
L
Y
E
LHSH
D
V
V
H
M
DV
K
P
E
N
I
L
--
R
R
QLDA
D
T
F
--
I
F
K
L
CDFGLARPLNGKDSVTGE
H
F
LGLNDDDGDRRYM
S
P
E
L
L
K
N
L
----
H
D
VVGPP
A
D
M
Y
A
L
G
K
S
C
E
A
M
M------------T-----A--T-----EDPSNT--------------
S
-----------------
A
R
-----------
H
L
----------
E
-----------SY-S
P
A
F
I
A
L
I
E
S
--------
M
LCEDPARR
P
S
A
F
Q
V
V
Q
-----
A
T
L
P
E
R
L
LSDG
G
L
L
E
L
Q
R
R
I
D
A
I
R
C
E
ISDLDASDNDVMSSPRT---------------------------
20
PsiBlast_PDB
84.24
23%
-22
- C1 -
-
2V7O
3
KCC2G_HUMAN
A:
[21-311]
-----------------------
Q
S
M
-
A
T
C
T
R
F
T
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
-
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
------
A
R
D
H
Q
K
L
E
R
-
E
A
R
I
C
R
-
L
L
-
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
DLVTGG
E
-----
L
F
E
D
I
-
V
--------
A
R
-----------
E
Y
Y
S
E
A
D
----------
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
--
L
A
S
K
C
K
G
A
A
--
V
-
K
L
A
D
F
G
L
A
I
E
V
Q
G
E
Q
Q
A
----
W
F
G
F
A
G
T
P
G
---
Y
L
S
P
E
V
L
R
K
------
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
------------
V
-----
G
--
Y
PPFWD
E
D
Q
H
K
L
--------------
Y
-----------------
Q
Q
IKAGAYDFPSP
E
W
----------
D
-----------
T
V
-
T
P
E
A
K
N
L
I
N
Q
--------
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
-----
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
R
----------------------------------------------
15
PsiBlast_PDB
75.56
29%
-16
- C1 -
-
3P1A
12
PMYT1_HUMAN
A:
[56-299]
----------------------
Q
Q
S
F
-
Q
R
L
S
R
L
G
H
----------
G
S
Y
G
-
E
V
F
K
V
R
S
K
E
D
G
R
L
Y
A
V
K
R
S
M
S
P
F
R
-
G
------
P
K
D
R
A
R
K
L
A
-
E
V
G
S
H
E
-
K
V
-
G
Q
H
P
C
C
V
R
L
E
Q
A
W
E
E
G
G
I
L
Y
L
Q
T
------
E
-----
L
C
G
P
S
-
L
Q
Q
H
C
E
A
W
G
A
S
L
---
P
----------
E
A
Q
----------
V
W
G
Y
L
R
D
T
L
L
A
L
A
H
L
H
S
Q
G
L
V
H
L
D
V
K
P
A
N
I
F
--
L
----
G
P
R
G
--
R
C
K
L
G
D
F
G
L
L
V
E
L
G
--------------
V
Q
E
G
D
P
R
Y
M
A
P
E
L
L
Q
G
S
----
Y
---
G
T
A
A
D
V
F
S
L
G
L
T
I
L
E
V
A
------------
C
-----
N
--
M
-----
E
L
P
H
G
G
--------------
E
-----------------
G
W
-----------
Q
Q
L
R
--------
Q
-----------
G
Y
L
P
P
E
F
T
A
G
L
S
S
E
L
R
S
V
L
V
M
M
L
E
P
D
P
K
L
R
A
T
A
--------------------------------------------------------------------------------
31
HHSearch
74.52
23%
-12
- C1 -
-
3KK8
-
KCC2D_CAEEL
A:
[3-277]
-------------------------------
K
F
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
-
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
-
S
------
A
R
D
F
Q
K
L
E
R
-
E
A
R
I
C
R
-
K
L
-
Q
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
------
D
-----
L
V
T
G
G
E
L
F
-------
E
D
I
V
A
-
R
------
E
F
Y
S
E
A
D
----------
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
--
L
A
S
K
A
-
K
G
A
--
A
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
E
--------
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
D
------
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
------------
V
-----
G
YP
P
-----
F
W
D
E
D
Q
--------------
H
R
L
Y
A
Q
I
K
A
G
A
Y
D
Y
P
---
S
P
-----------
E
W
----------
D
-----------
T
V
-
T
P
E
A
K
S
L
I
D
S
--------
M
L
T
V
N
P
K
K
R
I
T
A
D
Q
A
L
K
-----
V
P
W
I
C
N
R
E
R
V
A
S
A
I
H
R
------------------------------------------------------
30
HHSearch
74.19
24%
-10
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[8-274]
-------------------------------
K
F
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
-
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
-
S
------
A
R
D
F
Q
K
L
E
R
-
E
A
R
I
C
R
-
K
L
-
Q
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
------
D
-----
L
V
T
G
G
E
L
F
-------
E
D
I
V
A
-
R
------
E
F
Y
S
E
A
D
----------
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
--
L
A
S
K
A
-
K
G
A
--
A
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
E
--------
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
D
------
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
------------
V
-----
G
YP
P
-----
F
W
D
E
D
Q
--------------
H
R
L
Y
A
Q
I
K
A
G
A
Y
D
Y
P
---
S
P
-----------
E
W
----------
D
-----------
T
V
-
T
P
E
A
K
S
L
I
D
S
--------
M
L
T
V
N
P
K
K
R
I
T
A
D
Q
A
L
K
-----
V
P
W
I
C
N
R
---------------------------------------------------------------
12
PsiBlast_PDB
71.10
26%
-48
- C1 -
-
3DAE
-
SNF1_YEAST
A:
[58-315]
---------------------------------------
V
K
T
L
G
E
G
S
F
G
-
K
V
K
L
A
Y
H
T
T
T
G
Q
K
V
A
L
K
I
I
N
K
K
V
L
-
A
----------
Q
G
R
I
E
R
E
I
S
Y
L
R
-
L
L
-
R
-
H
P
H
I
I
K
L
Y
D
V
I
K
S
K
D
E
I
I
M
V
I
------
E
Y
A
GN-
E
L
F
D
Y
-
I
--------
V
Q
----
R
------
D
K
M
S
E
Q
E
----------
A
R
R
F
F
Q
Q
I
I
S
A
V
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
-----
L
D
E
H
L
N
--
V
-
K
I
A
D
F
------------------------
G
S
P
N
Y
A
A
P
E
V
I
S
G
-----
K
L
Y
A
G
P
E
V
D
V
W
S
C
G
V
I
L
Y
V
M
L
CRRLPFDDES
I
P
V
-----
L
--
F
-----
K
N
I
S
N
G
--------------
V
-----------------
Y
T
-----------
L
P
----------
K
-----------
F
L
-
S
P
G
A
A
G
L
I
K
R
--------
M
L
I
V
N
P
L
N
R
I
S
I
H
E
I
M
Q
DDWFK
V
D
L
P
E
Y
L
L
--------------------------------------------------------------
37
HHSearch
70.11
24%
-11
- C1 -
-
2VN9
1
KCC2D_HUMAN
B:
[2-268]
--------------------------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
-
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
------
A
R
D
H
Q
K
L
E
R
-
E
A
R
I
C
R
-
L
L
-
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
------
D
-----
L
V
T
G
G
E
L
F-------
E
D
I
VA-
R
------
E
Y
Y
S
E
A
D
----------
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
--
L
A
S
K
S
-
K
G
A
--
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
-------
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
------
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
------------
V
-----
G
YP
P
-----
F
W
D
E
D
Q
--------------
H
RLYQQIKAGAYDFP---
S
P
-----------
E
W
----------
D
-----------
T
V
-
T
P
E
A
K
D
L
I
N
K
--------
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
-----
H
P
W
I
C
Q
R
S
--------------------------------------------------------------
35
HHSearch
70.00
23%
-30
- C1 -
-
1U5R
1
TAOK2_RAT
A:
[51-315]
-------------------------------
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
-
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
------
N
E
K
W
Q
D
I
I
K
-
E
V
R
F
L
Q
-
K
L
-
R
-
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
H
T
A
W
L
V
M
------
E
-----
Y
C
L
G
S
-
A
S
-------
D
L
L
E
V
H
K
------
K
P
L
Q
E
V
E
----------
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
--
L
S
E
--
P
G
----
L
V
K
L
G
D
F
G
S
A
S
I
M
A
P
A
N
-----------
S
F
V
G
T
P
Y
W
M
A
P
E
V
I
L
A
M
D
---
E
G
Q
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
------------
E
-----
R
KP
P
-----
L
F
N
M
N
A
--------------
M
S
A
L
Y
H
I
A
QNESP-----
A
L
-----------
Q
S
----------
G
-----------
H
W
-
S
E
Y
F
R
N
F
V
D
S
--------
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
-----
H
R
F
V
L
R
E
R
P
P
------------------------------------------------------------
25
HHSearch
69.05
21%
-21
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[20-292]
------------------------------
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
-
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
-
T
S
SP---
G
L
S
T
E
D
L
K
R
-
E
A
S
I
C
H
-
M
L
-
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
------
E
-----
F
M
D
G
A
D
L
C
-------
F
E
I
---
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
----------
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
--
L
A
S
K
E
-
N
S
A
--
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
-------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
------------
S
-----
G
CL
P
-----
F
Y
G
T
K
E
--------------
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
----
P
R
-----------
Q
W
----------
S
-----------
H
I
-
S
E
S
A
K
D
L
V
R
R
--------
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
-----
H
P
W
L
K
E
----------------------------------------------------------------
33
HHSearch
68.66
24%
-4
- C1 -
-
4NIF
-
KS6A1_HUMAN
A:
[5-269]
-------------------------------
V
F
S
D
G
Y
V
V
K
E
T
I
G
V
G
S
Y
S
-
E
C
K
R
C
V
H
K
A
T
N
M
E
Y
A
V
K
V
I
D
K
S
K
-------------
R
D
P
S
E
-
E
I
E
I
L
L
R
Y
G
-
Q
-
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
H
V
Y
L
V
T
------
E
-----
L
M
R
G
G
E
L
L
-------
D
K
I
L
R
-
Q
------
K
F
F
S
E
R
E
----------
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
--
Y
V
D
E
S
G
N
P
E
--
C
L
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
N
G
-------
L
L
M
T
P
C
Y
---
F
V
A
P
E
V
L
K
R
Q
------
G
Y
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
------------
A
-----
G
YT
P
-----
F
A
N
G
P
S
--------------
D
T
P
E
E
I
L
T
R
I
G
S
GKFTLS
G
G
-----------
N
W
----------
N
-----------
T
V
-
S
E
T
A
K
D
L
V
S
K
--------
M
L
H
V
D
P
H
Q
R
L
T
A
K
Q
V
L
Q
-----
H
P
W
V
T
Q
----------------------------------------------------------------
46
Fugue
68.65
22%
20
- C1 -
-
1KOB
1
?
A:
[23-374]
------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
-
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
---
Y
------
P
L
D
K
Y
T
V
K
N
-
E
I
S
I
M
N
-
Q
L
-
H
-
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
------
E
F
L
S
G
G
E
L
F
D
R
-
I
--------
A
A
E
---
D
------
Y
K
M
S
E
A
E
----------
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
--
C
E
T
K
K
A
S
S
----
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
I
V
K
V
T
T
--------
A
T
A
E
F
A
A
P
E
I
V
D
R
------
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
------------
S
GLSPF
A
--
G
-----
E
D
D
L
E
T
--------------
L
-----------------
Q
N
-----------
V
K
----------
R
C
D
W
E
F
DEDAFS
S
V
-
S
P
E
A
K
D
F
I
K
N
--------
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
-----
H
P
W
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
IANFSSLRKHRPQEYQ
I
Y
D
S
Y
F
DRKEA
27
HHSearch
68.10
21%
-17
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[19-292]
-----------------------------
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
-
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
-
T
S
SP---
G
L
S
T
E
D
L
K
R
-
E
A
S
I
C
H
-
M
L
-
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
------
E
-----
F
M
D
G
A
D
L
C
-------
F
E
I
---
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
----------
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
--
L
A
S
K
E
-
N
S
A
--
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
-------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
------------
S
-----
G
CL
P
-----
F
Y
G
T
K
E
--------------
R
L
F
E
G
I
I
K
GKYKMN----
P
R
-----------
Q
W
----------
S
-----------
H
I
-
S
E
S
A
K
D
L
V
R
R
--------
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
-----
H
P
W
L
K
E
----------------------------------------------------------------
39
HHSearch
67.10
24%
10
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[92-364]
--------------------------------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
-
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
----
R
LSPEQL
E
E
V
R
E
A
T
R
R
-
E
T
H
I
L
R
-
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
------
D
-----
L
M
R
K
G
E
L
F-------
D
Y
L
TE-
K
------
V
A
L
S
E
K
E
----------
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
--
L
D
D
--
N
M
----
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
--------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
MDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
------------
A
-----
G
SP
P
-----
F
W
H
R
R
Q
--------------
I
LMLRMIMEGQYQFS---
S
P
-----------
E
W
----------
D
-----------
D
R
-
S
S
T
V
K
D
L
I
S
R
--------
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
-----
H
P
F
F
E
-----------------------------------------------------------------
42
HHSearch
66.75
21%
-24
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-267]
----------------------------------
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
-
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
---------
G
E
D
F
A
V
V
Q
Q
-
E
I
I
M
M
K
-
D
C
-
K
-
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
D
K
L
W
I
C
M
------
E
-----
F
C
G
G
G
S
L
Q
-------
D
I
Y
H
V-
T
------
G
P
L
S
E
L
Q
----------
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
--
L
T
D
--
N
G
----
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A
----------
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
E
R---
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
------------
E
-----
L
QP
P
-----
M
F
D
L
H
P
--------------
M
R
A
L
F
L
M
TKS
N
F
Q
P
P
K--
L
K
-----------
D
K
----------
M
-----------
K
W
-
S
N
S
F
H
H
F
V
K
M
--------
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
-----
H
P
F
V
T
Q
----------------------------------------------------------------
5
PsiBlast_PDB
66.59
28%
27
- C1 -
-
3CQE
2
A:
[5-280]
------------------------------
S
R
Y
T
T
E
F
H
E
L
E
K
I
G
S
G
E
F
G
S
V
F
K
C
V
K
R
-
L
D
G
C
I
Y
A
I
K
R
S
K
K
P
L
A
-
G
------
S
V
D
E
Q
N
A
L
R
-
E
V
Y
A
H
A
-
V
L
G
Q
-
H
S
H
V
V
R
Y
F
S
A
W
A
E
D
D
H
M
L
I
Q
N
------
E
-----
Y
C
N
G
-----------
G
S
L
---
A
------
D
A
I
S
E
N
Y
R
I
MSYFK
E
A
E
L
K
D
L
L
L
Q
V
G
R
G
L
R
Y
I
H
S
M
S
L
V
H
M
D
I
K
P
S
N
I
F
IS---------K
V
M
F
K
I
G
D
L
G
H
V
T
R
I
S
S
P
Q
V
-----------
E
E
G
D
S
R
F
L
A
N
E
V
L
Q
E
N
----
Y
T
H
L
-
P
K
A
D
I
F
A
L
A
L
T
V
V
C
A
A
------------
G
-----
A
--
E
-----
P
L
P
R
N
G
--------------
D
-----------------
Q
W
-----------
H
E
I
R
Q
GRLPRIP
Q
-----------
V
L
-
S
Q
E
F
T
E
L
L
K
V
--------
M
I
H
P
D
P
E
R
R
P
S
A
M
A
L
V
K
-----
H
S
V
-------------------------------------------------------------------
21
HHSearch
66.00
24%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[2-270]
--------------------------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
-
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
------
A
R
D
H
Q
K
L
E
R
-
E
A
R
I
C
R
-
L
L
-
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
------
D
-----
L
V
T
G
G
E
L
F
-------
E
D
I
V
A
-
R
------
E
Y
Y
S
E
A
D
----------
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
--
L
A
S
K
S
-
K
G
A
--
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
-------
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
------
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
------------
V
-----
G
YP
P
-----
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
GAYDF
P
-----------------
S
P
-----------
E
W
----------
D
-----------
T
V
-
T
P
E
A
K
D
L
I
N
K
--------
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
-----
H
P
W
I
C
Q
----------------------------------------------------------------
1
PsiBlast_PDB
66.00
28%
32
- C1 -
-
1X8B
-
A:
[7-282]
------------------------------
S
R
Y
T
T
E
F
H
E
L
E
K
I
G
S
G
E
F
G
S
V
F
K
C
V
K
R
-
L
D
G
C
I
Y
A
I
K
R
S
K
K
P
L
A
-
G
------
S
V
D
E
Q
N
A
L
R
-
E
V
Y
A
H
A
-
V
L
G
Q
-
H
S
H
V
V
R
Y
F
S
A
W
A
E
D
D
H
M
L
I
Q
N
------
E
-----
Y
C
N
G
-----------
G
S
L
---
A
------
D
A
I
S
E
N
Y
R
I
MSYFK
E
A
E
L
K
D
L
L
L
Q
V
G
R
G
L
R
Y
I
H
S
M
S
L
V
H
M
D
I
K
P
S
N
I
F
IS---------K
V
M
F
K
I
G
D
L
G
H
V
T
R
I
S
S
P
Q
V
-----------
E
E
G
D
S
R
F
L
A
N
E
V
L
Q
E
N
----
Y
T
H
L
-
P
K
A
D
I
F
A
L
A
L
T
V
V
C
A
A
------------
G
-----
A
--
E
-----
P
L
P
R
N
G
--------------
D
-----------------
Q
W
-----------
H
E
I
R
Q
GRLPRIP
Q
-----------
V
L
-
S
Q
E
F
T
E
L
L
K
V
--------
M
I
H
P
D
P
E
R
R
P
S
A
M
A
L
V
K
-----
H
S
V
-------------------------------------------------------------------
44
HHSearch
65.94
22%
-21
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-350]
---------------------------------
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
-
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---------
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
-
D
Y
-
Q
-
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
------
E
-----
F
L
E
G
G
A
L
T
-------
D
I
V
T
--
H
------
T
R
M
N
E
E
Q
----------
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
--
L
T
H
--
D
G
----
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
-------
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
------
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
------------
D
-----
G
EP
P
-----
Y
F
N
E
P
P
--------------
L
K
A
M
K
M
I
R
DNLPPR----
L
K
-----------
N
L
----------
H
-----------
K
V
-
S
P
S
L
K
G
F
L
D
R
--------
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
-----
H
P
F
L
A
K
A
---------------------------------------------------------------
2
PsiBlast_PDB
65.75
28%
31
- C1 -
-
2Z2W
2
A:
[3-278]
------------------------------
S
R
Y
T
T
E
F
H
E
L
E
K
I
G
S
G
E
F
G
S
V
F
K
C
V
K
R
-
L
D
G
C
I
Y
A
I
K
R
S
K
K
P
L
A
-
G
------
S
V
D
E
Q
N
A
L
R
-
E
V
Y
A
H
A
-
V
L
G
Q
-
H
S
H
V
V
R
Y
F
S
A
W
A
E
D
D
H
M
L
I
Q
N
------
E
-----
Y
C
N
G
-----------
G
S
L
---
A
------
D
A
I
S
E
N
Y
R
I
MSYFK
E
A
E
L
K
D
L
L
L
Q
V
G
R
G
L
R
Y
I
H
S
M
S
L
V
H
M
D
I
K
P
S
N
I
F
IS---------K
V
M
F
K
I
G
D
L
G
H
V
T
R
I
S
S
P
Q
V
-----------
E
E
G
D
S
R
F
L
A
N
E
V
L
Q
E
N
----
Y
T
H
L
-
P
K
A
D
I
F
A
L
A
L
T
V
V
C
A
A
------------
G
-----
A
--
E
-----
P
L
P
R
N
G
--------------
D
-----------------
Q
W
-----------
H
E
I
R
QGRLPRIP
Q
-----------
V
L
-
S
Q
E
F
T
E
L
L
K
V
--------
M
I
H
P
D
P
E
R
R
P
S
A
M
A
L
V
K
-----
H
S
V
-------------------------------------------------------------------
3
PsiBlast_PDB
65.28
28%
33
- C1 -
-
3BI6
1
A:
[5-280]
------------------------------
S
R
Y
T
T
E
F
H
E
L
E
K
I
G
S
G
E
F
G
S
V
F
K
C
V
K
R
-
L
D
G
C
I
Y
A
I
K
R
S
K
K
P
L
A
-
G
------
S
V
D
E
Q
N
A
L
R
-
E
V
Y
A
H
A
-
V
L
G
Q
-
H
S
H
V
V
R
Y
F
S
A
W
A
E
D
D
H
M
L
I
Q
N
------
E
-----
Y
C
N
G
-----------
G
S
L
---
A
------
D
A
I
S
E
N
Y
R
I
MSYFK
E
A
E
L
K
D
L
L
L
Q
V
G
R
G
L
R
Y
I
H
S
M
S
L
V
H
M
D
I
K
P
S
N
I
F
IS---------K
V
M
F
K
I
G
D
L
G
H
V
T
R
I
S
S
P
Q
V
-----------
E
E
G
D
S
R
F
L
A
N
E
V
L
Q
E
N
----
Y
T
H
L
-
P
K
A
D
I
F
A
L
A
L
T
V
V
C
A
A
------------
G
-----
A
--
E
-----
P
L
P
R
N
G
--------------
D
-----------------
Q
W
-----------
H
E
I
R
Q
GRLPRIP
Q
-----------
V
L
-
S
Q
E
F
T
E
L
L
K
V
--------
M
I
H
P
D
P
E
R
R
P
S
A
M
A
L
V
K
-----
H
S
V
-------------------------------------------------------------------
38
HHSearch
65.25
24%
4
* C1 *
-
2Y7J
1
PHKG2_HUMAN
C:
[92-364]
--------------------------------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
-
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
-
R
LSPEQL
E
E
V
R
E
A
T
R
R
-
E
T
H
I
L
R
-
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
------
D
-----
L
M
R
K
G
E
L
F-------
D
Y
L
TE-
K
------
V
A
L
S
E
K
E
----------
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
--
L
D
D
--
N
M
----
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
--------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
MDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
------------
A
-----
G
SP
P
-----
F
W
H
R
R
Q
--------------
I
LMLRMIMEGQYQFS---
S
P
-----------
E
W
----------
D
-----------
D
R
-
S
S
T
V
K
D
L
I
S
R
--------
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
-----
H
P
F
F
E
-----------------------------------------------------------------