@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_30_1060: (2018-03-11 )
MNSQASSSPLPPAASCVQFRPEQLQLGTGIPLGSGAISQVVQCRLHCAAAPLLPVVVKVVSKIQVLQQGKVQSVMNEKATLQRLAPFPYVVRLYGTAQSEDELYFVLEWLPHGDLLQHIRYVAQERVRQYNEEEAAAGSTASMPSPGAVAGGTTGSVPDGAPVAEASASTGPSKRATAIPASSTALRCLDFHDIQLITAQLVLALEHTADRGVVLRDLKPENVAFDEKYRACLLDFDTADLEGAVNMPETNGGVACPPPVDAAAVDEAESSDGGGGHAAAENGGASSSSRRRRLTVSQIHRMRRKTASFCGTAHYVSPEMVGECKWSFSSDLWALGALVYELVYGEHLFSGMTPFEVLQKVVHGSYVERHELFPHIHFADDADGEAEQCCGERRFAAVKDFIQQLLLTDPQKRLGVHPDTHRFDATALRRHALFDGFQWEPVEAQLRTFRMRRFDLGSSKATSAASGDASCDAREASNDASGASSAALKSLVAACVDPSASLASCYHILPFNDPAYAEYVYRATADANPFEQFFTQEDTEPAPTAAAASHEAAGSAGGSAPGAVPTPAVNSRPEAASVVDDDEVDDVIDDVGMHYTGRPADKYFQDYRDTP
Atome Classification :
(20 SA)
------------------------------------.........10-------------.........20........30........40........50........60.....-.-..70........80....--....90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210........220.......230.......240.......250.......260.......270.......280.......290....------..-------.300.......310.......320----.-------..-.----....330.......340.......350.......360.......370.......380.......390.......400.......410---.......420.......430.......440-....--.--...450.......460.....---..470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------------------MNSQASSSPL--------------PP
A
A
S
C
V
QF
R
P
E
QLQLGTGIPL
G
S
G
A
I
S
Q
V
V
Q
C
R
L
HCAAA
P
L
L
P
V
V
V
K
V
V
S
K
I
Q
V
L
-
Q
-QG
K
V
Q
S
V
M
N
E
K
A
T
L
Q
RLA--PFP
Y
V
V
R
L
YGTAQSED
E
L
Y
F
V
L
EWLP
H
G
D
L
L
Q
H
I
R
Y
V
A
Q
E
R
V
R
Q
Y
N
E
E
E
AAAGSTASMPSPGAVAGGTTGSVPDGAPVAEASASTGPSKR
A
T
AIPASS
T
A
L
R
C
LDF
H
D
I
Q
L
I
T
A
Q
L
V
L
A
L
EHTAD-R
G
V
V
L
RDLKPENV
A
F
D
E
K
Y
R
A
C
LLDFDTADLEGAVNMPETNGGVACPPPV
D
A
A
AVDEAESSDGGGGHAAAENGGASSSSRRRRL
T
V
------
S
Q
-------
I
H
R
M
R
R
K
T
A
S
F
CGTAHYV
S
P
E
M
V
-----
G
-------EC-K----WSFS
S
D
L
W
A
L
G
A
L
V
Y
E
L
V
Y
G
E
H
L
FSGM
T
P
F
E
V
L
Q
K
V
V
H
G
S
Y
V
E
R
H
ELFPH
I
H
FADDADG
E
A
E
Q
C
CGER
R
F
A
A
V
K
D
F
I
Q
Q
L
LLT
D
P
Q
K
---RLGVHPDTHRF
D
A
T
A
L
R
R
H
A
LFDGFQWE
P
--
V
E
A
Q
--
L
--
R
T
F
R
M
R
RFDLGSSKATSAASG---DASCDAREASNDASG
A
S
S
A
A
L
K
S
L
V
A
A
CVDP
S
A
S
L
A
S
C
Y
H
ILPFND
P
A
Y
A
E
Y
V
YRATADA
N
P
F
E
Q
F
F
TQEDTEPAPTAAAASHEAAGSAGGSAPGAVPTPAVNSRPEAASVVD
D
D
E
V
D
D
V
I
D
D
VGMHYTGR
P
A
D
K
Y
F
Q
D
YRDTP
41
HHSearch
79.99
27%
-112
- C1 -
-
4WIH
-
KAPCA_CRIGR
A:
[46-331]
---------------------------------------------------------------------------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
----------------------------------------------------------------
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
-------------------------------------------------------------------------
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-------
S
K
-
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
-----
R
F
P
-----------------
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
---
R
F
G
N
L
K
N
----
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
--
I
Y
Q
R
KV
E
--
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
78.83
26%
-112
- C1 -
-
1RDQ
3
KAPCA_MOUSE
E:
[42-328]
--------------------------------------------------------------------------
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
----------------------------------------------------------------
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
-------------------------------------------------------------------------
R
T
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
-----
L
-------
S
K
-
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
-----
R
F
P
-----------------
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
---
R
F
G
N
L
K
N
----
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
--
I
Y
Q
R
KV
E
--
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
76.02
24%
-4
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
GPAQTNGQCFS
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
L
RRE
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
N
A
D
K
---
V
F
A
M
K
I
L
N
K
W
E
M
L
-
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
-
G
--
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
R
---------------------------------------------------------------
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
-------------------------------------
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
S
V
A
V
--------------------------------
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
G
G
-------
K
G
-
R
----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
-----
H
K
E
R
F
Q
F
P
T
Q
V
T
D
V
S
------------
E
N
A
K
D
L
I
R
R
L
I
C
S
-
R
E
H
---
R
L
G
------
Q
N
G
I
E
D
F
K
K
H
P
F
F
S
G
I
D
W
D
N
--
I
R
N
C
--
E
--
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
S
G
HHL
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
R
----------------------------------------------------------------------------------------------------------------------------
35
HHSearch
74.82
28%
-132
- C1 -
-
2I0E
-
KPCB_HUMAN
A:
[22-293]
---------------------------------------------------------------------------
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
S
E
R
K
G
---
T
D
E
L
Y
A
V
K
I
L
K
K
D
V
V
I
-
Q
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
A
L
P
G
--
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
G
----------------------------------------------------------------
R
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
N
I
W
D
G
----------------------------------------------------------------------
V
T
T
K
T
F
C
G
T
P
D
Y
I
A
P
E
I
I
-----
A
-------
Y
Q
-
P
----
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
A
P
F
E
G
E
D
E
D
E
L
F
Q
S
I
M
E
H
N
V
-----
A
Y
P
-----------------
K
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
---
R
L
G
C
G
P
E
----
G
E
R
D
I
K
E
H
A
F
F
R
Y
I
D
W
E
K
--
L
E
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
74.29
28%
-116
- C1 -
-
4RA5
3
KPCT_HUMAN
A:
[7-292]
---------------------------------------------------------------------------
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
---
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
-
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
--
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
----------------------------------------------------------------
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
----------------------------------------------------------------------
D
A
K
T
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
-----
L
-------
G
Q
-
K
----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
E
E
L
F
H
S
I
R
M
D
N
P
-----
F
Y
P
-----------------
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
---
R
L
G
V
--------
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
--
L
E
R
K
EI
D
--
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
72.48
28%
-111
- C1 -
-
5F9E
1
KPCT_HUMAN
A:
[20-306]
--------------------------------------------------------------------------
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
---
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
-
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
--
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
----------------------------------------------------------------
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
----------------------------------------------------------------------
D
A
K
T
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
-----
L
-------
G
Q
-
K
----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
E
E
L
F
H
S
I
R
M
D
N
P
-----
F
Y
P
-----------------
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
---
R
L
G
V
--------
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
--
L
E
R
K
EI
D
--
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
70.92
27%
-130
- C1 -
-
3TXO
1
A:
[25-315]
---------------------------------------------------------------------------
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
E
---
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
-
Q
-
D
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
R
--
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
R
----------------------------------------------------------------
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
-------------------------------------------------------------------------------
G
T
P
D
Y
I
A
P
E
I
L
-----
Q
-------
E
M
-
L
----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
E
D
D
L
F
E
A
I
L
N
D
E
V
-----
V
Y
P
T
-----------------
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
---
R
L
G
S
L
T
Q
G
---
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
--
L
N
H
R
QI
E
--
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
69.78
28%
0
- C- -
-
2I0E
-
B:
[22-320]
---------------------------------------------------------------------------
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
S
E
R
K
G
---
T
D
E
L
Y
A
V
K
I
L
K
K
D
V
V
I
-
Q
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
A
L
P
G
--
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
G
----------------------------------------------------------------
R
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
N
I
W
D
G
----------------------------------------------------------------------
V
T
T
K
T
F
C
G
T
P
D
Y
I
A
P
E
I
I
-----
A
-------
Y
Q
-
P
----
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
A
P
F
E
G
E
D
E
D
E
L
F
Q
S
I
M
E
H
N
V
-----
A
Y
P
-----------------
K
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
---
R
L
G
C
G
P
E
----
G
E
R
D
I
K
E
H
A
F
F
R
Y
I
D
W
E
K
--
L
E
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
68.42
25%
-121
- C1 -
-
5LI9
13
KPCI_HUMAN
A:
[9-307]
----------------------------------------------------------------------------
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
K
K
---
T
D
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
-
D
-
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
--
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
R
----------------------------------------------------------------
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
----------------------------------------------------------------------
D
T
T
S
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
-----
R
-------
G
E
-
D
----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
------------
T
E
D
Y
L
F
Q
--
V
I
L
E
K
Q
-
I
----------
R
I
P
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
---
R
L
G
C
H
P
Q
T
---
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
--
M
E
Q
K
QV
V
--
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
68.02
26%
-140
- C1 -
-
5LOH
3
GWL_HUMAN
B:
[38-316]
---------------------------------------------------------------------------
F
S
I
V
K
P
I
S
R
G
A
F
G
K
V
Y
L
G
Q
K
G
-----
G
K
L
Y
A
V
K
V
V
K
K
A
D
M
I
-
N
-
K
-------------
A
L
S
---
K
S
P
F
I
V
H
L
Y
Y
S
L
Q
S
A
N
N
V
Y
L
V
M
E
Y
L
I
G
G
D
V
K
S
L
L
H
I
Y
G
----------------------------------------------------------------
Y
F
D
E
E
M
A
V
K
Y
I
S
E
V
A
L
A
L
D
Y
L
H
R
-
H
G
I
I
H
R
D
L
K
P
D
N
M
L
I
S
N
E
G
H
I
K
L
T
D
F
G
L
-------------------------------------------------------------------------------------
G
T
P
D
Y
L
A
P
E
L
L
-----
L
-------
G
R
-
A
----
H
G
P
A
V
D
W
W
A
L
G
V
C
L
F
E
F
L
T
G
I
P
P
F
N
D
E
T
P
Q
Q
V
F
Q
N
I
L
K
R
D
I
P
-----
W
P
E
G
--------------
E
E
K
L
S
D
N
A
Q
S
A
V
E
I
L
L
T
I
D
D
T
K
---
R
A
---------
G
M
K
E
L
K
R
H
P
L
F
S
D
V
D
W
E
N
--
L
Q
H
Q
--
T
--
M
P
F
I
P
Q
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
66.50
26%
-63
- C1 -
-
3WF7
2
KS6B1_HUMAN
A:
[21-293]
---------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
-
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
---
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
----------------------------------------------------------------
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
-------------------------------------------------------------------------
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
-----
M
-------
R
S
-
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
-----
L
-----------------
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
---
R
L
G
A
G
P
G
----
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
--
L
L
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
65.20
27%
-35
- C- -
-
4OTD
-
PKN1_HUMAN
A:
[621-891]
---------------------------------------------------------------------------
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
F
R
P
---
S
G
E
L
F
A
I
K
A
L
K
K
G
D
I
V
-
A
-
R
D
E
V
E
S
L
M
C
E
K
R
I
L
A
A
V
T
SA
G
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
D
-----------------------------------------------------------------
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
G
Y
V
K
I
A
D
F
G
L
C
K
E
G
M
G
Y
G
----------------------------------------------------------------------
D
R
T
S
T
F
C
G
T
P
E
F
L
A
P
E
V
L
-----
T
-------
D
T
-
S
----
Y
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
S
P
F
P
G
D
D
E
E
E
V
F
D
S
I
V
N
D
E
V
-----
R
Y
P
-----------------
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
---
R
L
G
S
S
E
R
----
D
A
E
D
V
K
K
Q
P
F
F
R
T
L
G
W
E
A
--
L
L
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
64.85
24%
-59
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[10-304]
---------------------------------------------------------------------------
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
---
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
----------------------------------------------------------------
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
----------------------------------------------------------------------
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
-----
E
-------
D
N
-
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
-----
R
F
P
-----------------
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
---
R
L
G
G
G
S
E
----
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
--
V
Y
E
K
--
K
LS
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
64.47
26%
-93
- C1 -
-
2VD5
-
DMPK_HUMAN
A:
[63-367]
---------------------------------------------------------------------------
F
E
I
L
K
V
I
G
R
G
A
F
S
E
V
A
V
V
K
M
K
Q
---
T
G
Q
V
Y
A
M
K
I
M
N
K
W
D
M
L
-
K
-
R
G
E
V
S
C
F
R
E
E
R
D
V
L
V
N
G
---
D
R
R
W
I
T
Q
L
H
F
A
F
Q
D
E
N
Y
L
Y
L
V
M
E
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
G
E
---------------------------------------------------------------
R
I
P
A
E
M
A
R
F
Y
L
A
E
I
V
M
A
I
D
S
V
H
R
-
L
G
Y
V
H
R
D
I
K
P
D
N
I
L
L
D
R
C
G
H
I
R
L
A
D
F
G
S
C
L
K
L
R
A
D
G
---------------------------------------------------------------------
T
V
R
S
L
V
A
V
G
T
P
D
Y
L
S
P
E
I
L
-----
Q
A
V
G
GGPG
T
G
-
S
----
Y
G
P
E
C
D
W
W
A
L
G
V
F
A
Y
E
M
F
Y
G
Q
T
P
F
Y
A
D
S
T
A
E
T
Y
G
K
I
V
H
Y
K
E
H
---
L
S
L
P
------------------
G
V
P
E
E
A
R
D
F
I
Q
R
L
L
C
P
P
E
T
R
LG-
R
G
---------
G
A
G
D
F
R
T
H
P
F
F
F
G
L
D
W
D
G
--
L
R
D
S
--
V
--
P
P
F
T
P
D
-----
D
T
C
N
F
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
63.09
28%
-57
- C1 -
-
1VZO
1
KS6A5_HUMAN
A:
[56-336]
---------------------------------------------------------------------------
F
E
L
L
K
V
L
G
T
G
A
Y
G
K
V
F
L
V
R
K
I
S
G
H
D
T
G
K
L
Y
A
M
K
V
L
K
K
A
T
I
V
-
Q
K
A
K
T
T
E
H
T
R
T
E
R
Q
V
L
E
H
I
R
--
Q
S
P
F
L
V
T
L
H
Y
A
F
Q
T
E
T
K
L
H
L
I
L
D
Y
I
N
G
G
E
L
F
T
H
L
S
Q
R
E
----------------------------------------------------------------
R
F
T
E
H
E
V
Q
I
Y
V
G
E
I
V
L
A
L
E
H
L
H
K
-
L
G
I
I
Y
R
D
I
K
L
E
N
I
L
L
D
S
N
G
H
V
V
L
T
D
F
G
L
S
K
E
F
V
A
D
E
---------------------------------------------------------------------
T
E
R
A
Y
D
F
C
G
T
I
E
Y
M
A
P
D
I
V
-----
R
-------
G
G
D------
D
K
A
V
D
W
W
S
L
G
V
L
M
Y
E
L
L
T
G
A
S
P
F
T
V
D
G
E
K
N
S
Q
A
E
I
S
R
R
I
L
K
S
-
E
P
P
Y
-----------------
P
Q
E
M
S
A
L
A
K
D
L
I
Q
R
L
L
M
K
D
P
K
K
---
R
L
G
C
G
P
R
----
D
A
D
E
I
K
E
H
L
F
F
Q
K
I
N
W
D
D
--
L
A
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
61.61
23%
-82
- C1 -
-
4WOT
1
ROCK2_HUMAN
B:
[71-366]
---------------------------------------------------------------------------
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
---
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
---
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
-----------------------------------------------------------------
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
---------------------------------------------------------------------
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
-----
K
-------
S
Q
-
G
GDGF
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
D
H
K
N
S
---
L
C
F
P
E
---------------
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG-
R
N
G
---------
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
W
H
W
--
D
N
I
R
ET
A
--
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
61.28
23%
-85
- C1 -
-
4LQS
1
CBK1_YEAST
A:
[104-466]
---------------------------------------------------------------------------
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
D
---
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
-
K
-
K
---------------
S
---
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
W
Q
----------------------------------------------------------------
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
-
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
H
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
H
D
S
N
Y
----------------------------------------------NRQQ
I
Q
T
W
-------
R
K
S
R
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
-----
L
-------
Y
Q
-
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
Q
E
T
Y
R
K
I
M
N
F
E
Q
T
---
L
Q
F
P
D
D
---------------
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
Q
R
LGR
H
G
---------
G
A
D
E
I
K
S
H
P
F
F
R
G
V
D
W
N
T
--
I
R
Q
V
--
E
--
A
P
Y
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
60.56
22%
-76
* C1 *
-
3V8S
1
ROCK1_HUMAN
D:
[71-364]
---------------------------------------------------------------------------
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
---
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
---
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
-----------------------------------------------------------------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
---------------------------------------------------------------------
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
-----
K
-------
S
Q
-
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
---
L
T
F
P
D
---------------
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG-
R
N
---------
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
ET
L
R
D
T
--
V
--
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
59.22
26%
0
- C- -
-
1FOT
-
KAPA_YEAST
A:
[87-368]
---------------------------------------------------------------------------
F
Q
I
L
R
T
L
G
T
G
S
F
G
R
V
H
L
I
R
S
R
H
---
N
G
R
Y
Y
A
M
K
V
L
K
K
E
I
V
V
-
R
-
L
K
Q
V
E
H
T
N
D
E
R
L
M
L
S
I
V
---
T
H
P
F
I
I
R
M
W
G
T
F
Q
D
A
Q
Q
I
F
M
I
M
D
Y
I
E
G
G
E
L
F
S
L
L
R
K
S
Q
----------------------------------------------------------------
R
F
P
N
P
V
A
K
F
Y
A
A
E
V
C
L
A
L
E
Y
L
H
S
-
K
D
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
K
N
G
H
I
K
I
T
D
F
G
F
A
K
Y
V
P
D
-------------------------------------------------------------------------
V
T
Y
T
L
C
G
T
P
D
Y
I
A
P
E
V
V
-----
S
-------
T
K
-
P
----
Y
N
K
S
I
D
W
W
S
F
G
I
L
I
Y
E
M
L
A
G
Y
T
P
F
Y
D
S
N
T
M
K
T
Y
E
K
I
L
N
A
E
L
-----
R
F
P
-----------------
P
F
F
N
E
D
V
K
D
L
L
S
R
L
I
T
R
D
L
S
Q
---
R
L
G
N
L
Q
N
----
G
T
E
D
V
K
N
H
P
W
F
K
E
V
V
W
E
K
--
L
L
S
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
58.06
23%
-85
- C1 -
-
4LQQ
1
CBK1_YEAST
A:
[104-466]
---------------------------------------------------------------------------
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
D
---
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
-
K
-
K
---------------
S
---
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
W
Q
----------------------------------------------------------------
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
-
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
H
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
H
D
S
N
Y
-------------------------------------------
L
T
M
------
S
N
RQQ
I
Q
T
W
R
K
S
R
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
-----
L
-------
Y
Q
-
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
Q
E
T
Y
R
K
I
M
N
F
E
Q
T
---
L
Q
F
P
D
D
---------------
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
Q
R
LGR
H
G
---------
G
A
D
E
I
K
S
H
P
F
F
R
G
V
D
W
N
T
--
I
R
Q
V
--
E
--
A
P
Y
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------