@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_30_1580: (2018-03-11 )
MASTETVWDGACLLLATDVAGVLHCYQYTTEKVSDGSTDNDDERVAVLTHLWSHSLGDEDVPSELVAAADGGTSPTASSIAASAKAERDARAGFKCALSKRLRLLEPASTMLARWAAAEGPRASGEHRDISSASPKSGFTEGHSRVNGGDADGACDTAARGTREGKIDGIPPVAAAHHFGLQAIGASCPFCKRVSFSSSSPSPAFTSPYSPCTPRFTSTSAATATQKPTCATTSATTSLLCSSTAGRAAIVRRRSEVREETVGDRRVSDASGDNFFRPCDFMARIPEAAYSGFNASAKARPAAAAGSITPVDLAAPTVGCASSQLAEVAWYWRCPRCVVDARATPDGGGSDAKRASHRYFVSEEEAGQLSRDDTAMETGDLAEVAATAHLWMPLPEAVRHWNAVCCHHHRLLLLRHMEEGYIELDLFTGASLDSIYMKADMKAAVSAEMLDSTSSFDISAHSIYSSVSDGSGTEVSHDSCASISDANGDGLPRAVLSLTTQRYETLIMQATVSRSSAKVTKGRKTRKETMTAPTQKAAHTCLAKLAAPAIQLGLTWHAPRQRVRKDLSFSDADDEAVVERQQGEAELLATSQVPAVLSFSSVSSENTLHHGSTSASDIDMDVMAGRKQLPPQYHFLRAVSPAPSSSAISATSPRGIRNEPTKWSREKPARPKYAGTDRSAESSAGREAVPNEIPVRCGPGGCVYRAVSATLDSFTAAGNGDSAPLQFLLLLQLPLPLVEAFWVTLPSSSASGCSQNGGDAAFRRRAGERSMSAVELRRVPWLPRDACSLRVVEVAAGAPISASSASEARTTLRGFVLEASEVPSARRAMSTGLPRVLRALSAYDVFSARRATVRSAWLARDRRGDCGPFSASSDAGERERAAEAAAAPEHRNGTRAVHTKSFSTPFPYESRETSSSITHIISSPPRHYIPAASFFDENFEPLMLLGRGVGGAVLLARHRFTGVFYAIKVLVARDYDSERDILQEVRIHAMLENRHLVRYHTCWSEVISATRAQQLAFIGVCHPYEANLGRCKRLNSASSSMPMTTRQSARDGASHSPTNSDGDMLNRSQSRGAPGGWRHLILPSLSSMMLVGSDSTSGAVTPEKTPMRSHPQLRGDGRRRLIVDGFADDLTDDDGDAMPVGQAEKRQGAADDCLRHSGKGISPPTKIGSQPSRRPLTFSSTASPSAWGTRASLTAHRLRKQLPITSVLSPGTSSAASNSVSGTTVQGVADSEGEDLESIWDDAQGSDSDRSEGSGDSYGSSQRPEENTIIGTRVVFLQMELCQGTLAQYLASRTSIDRVENLIIAMQVVAGLRYLHHRGILHRDVKPTNVFMNYRCQYHKEVHQTNLSSTSGADDGSEDEDDTRSFWGFPGSATSHSGASAAWHGDRGNEACAPSPSSTLTLCRRHPSSCPPTLASSGCGPSVSCAPRRSSMVPPGMQELFRAASSLTSGWKAETTMTSLDNLPSWDGERAALDFVMHPPHRTATEMLQERLLRRPPPPAARQRASSKCKLMKEEMTAADATMPLVQSDGGRHFLRRLASWLLRRFVQVQLGDLGLAKFLYQQELRVDGFVSMNAINTIGVGSPLYASPEQLKGNRCTPASDAFSVGVVLAEMYLQPKTTAERLTVLREVREGVYRDKVLLAQFPELKLVRRLTEAQPECRMTLAAVHKALRSFLEQALQDELYRHYE
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970..-----.....980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210..---....1220.-----.....1230......1240......1250......1260..----....1270-........1280...--....1290--.....-----.1300......1310......1320......1330.....----------.1340......1350......1360....--------..1370......1380......1390.......1400......1410......1420.......1430......1440....--..1450......1460....-..1470...-...1480......1490----.........---1500......1510----......1520......1530........1540...-..--.1550---........1560.--.....1570......-------1580.......1590...-----...1600......1610.--.-------....1620.--.....1630.---.....1640.-.--.--.--..1650......1660....--..1670.....--.1680.--------------....-----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MASTETVWD
G
A
C
L
L
L
A
T
D
V
A
G
V
L
H
C
Y
Q
Y
T
T
E
KVSDGSTDND
D
E
R
V
A
V
L
T
H
L
W
SHSLGDEDV
P
S
E
L
V
AAADGGTSP
T
A
S
S
I
A
A
S
A
KA
E
R
D
A
R
A
G
F
K
C
A
L
S
K
R
L
R
LLE
P
A
S
T
M
L
A
R
W
AAAEGPRASGEHRDISSASPKSGFTEGHSRVNGGDADGAC
D
T
AARGTREGKIDGIPP
V
A
A
A
H
H
F
G
L
Q
A
IGASCPFCKRVSFSSSSPSPAFTSPYSPCTPRFTSTSAATATQKPTCATTSA
T
T
S
L
L
CSSTA
G
R
A
A
I
V
R
R
R
S
E
V
R
E
E
TVGDRRVSDASGDNFF
R
P
C
D
F
M
A
R
I
P
E
A
A
YSGFNASAKARPAAAAGSI
T
P
V
DLAAPTVGC
A
S
S
Q
L
A
E
V
A
W
Y
WRCPR
C
V
VDARATPDGGGSDAKRASH
R
Y
F
VSEEEAGQLSRDDTAMETG
D
L
A
E
V
A
A
T
A
HLWMP
L
P
E
A
V
R
H
W
N
A
V
C
C
H
H
H
R
L
L
L
L
R
H
MEEG
Y
I
E
L
D
L
FTGASL
D
S
I
Y
M
K
A
D
M
K
A
A
V
S
A
E
M
LDSTSSF
D
I
S
A
H
S
I
Y
SSVSDGSGTEVSHDSCASISDANGDG
L
P
R
A
V
L
S
L
T
T
Q
R
Y
E
T
L
I
M
Q
ATVSRSSAKVTKGRKT
R
K
ETMTA
P
T
Q
K
A
A
H
T
C
L
A
K
L
A
A
P
A
I
Q
LGLTWHA
P
R
Q
R
V
R
K
DLSFSDAD
D
E
A
V
V
E
R
QQGEA
E
L
L
ATSQV
P
A
V
L
S
FSSVSSENTLHHGSTSASDI
D
M
D
V
MAGRKQLPP
Q
Y
H
F
L
R
AVSPAPSSSAISATSPRGIRNEPTKWSREKPARPKYAGTDRSAESSAGREAVPNEIPVRCGPG
G
C
V
Y
R
A
V
S
A
T
L
D
S
FTAAGNGD
S
A
P
L
Q
F
L
L
L
L
QL
P
L
P
L
V
E
A
F
W
VTLPSSSASGCSQNG
G
D
A
A
F
R
R
RAGERSM
S
A
V
E
L
RRVPWLPRDAC
S
L
R
V
V
E
V
AAGAPISASS
A
S
E
A
R
T
T
L
R
G
F
V
L
E
A
S
EVP
S
A
R
R
A
M
S
T
G
L
P
R
V
L
R
A
L
S
A
Y
D
V
F
S
A
R
R
A
T
V
R
S
A
W
L
ARDRRGDCGPFSASSDAG
E
R
E
R
A
A
E
AAAAPEHRNG
T
R
A
V
H
TKSFSTPFPYESRETS
S
S
I
T
H
I
ISSPPRHYI
P
A
A
S
F
F
DENF
E
P
L
M
L
LGRGVGG
A
V
L
L
A
R
H
R
F
T
G
V
F
Y
A
I
K
V
L
V
ARD-----YD
S
E
R
D
I
L
Q
E
V
R
I
H
A
M
LEN
R
H
L
V
R
Y
H
T
C
W
S
E
V
I
S
A
T
R
A
Q
Q
L
A
F
I
G
VCHPYEANL
G
R
C
K
RLNSASSSMPMT
T
R
QSARDGASHSPTNSDGDMLNRSQSRGAPGG
W
R
H
L
I
L
PSLS
S
M
M
L
V
GSDSTSGAVTPEKTPMRSHPQLRGDG
R
R
R
L
I
VDGFADDLTDDDGDAMPVG
Q
A
E
K
RQG
A
A
D
D
C
L
R
HSGKGISPPTKIGSQPSRRP
L
T
FSSTASPSAWGT
R
A
S
L
T
A
H
R
L
R
K
QLPITSVLSPGTSSA---ASNSVSG
T
T
-----
V
Q
GVADSEG
E
D
L
E
S
I
W
DDAQGSDSDRSEGSGDSYGSSQRPE----EN
T
I
I
G
---
T
R
V
V
F
L
Q
M
E
L
C
-
Q
G
T
--
L
A
Q
Y
L
A
SR--T
S
I
D
R
-----
V
E
N
L
I
I
A
M
Q
V
V
A
G
L
R
Y
L
H
HRGILHRDVKPT
N
V
F
M
N
Y
R
C
Q
Y
----------
H
K
E
V
H
QTNLSSTSGADDGSEDED
D
T
R
S
FW--------GFPGSATSHSGASAAWHGDRGNEAC-APSP
S
S
T
L
T
L
C
R
RHPSSCPPTLASSGCGP-SVSCAPRRSSMVP
P
G
M
Q
E
L
F
R
A
A
S
S
L--TSGWKAE
T
T
MTSLDNLPSWD-GE
R
A
A
L
D
F
V-MHPPH
R
T
A
T
E
M
L
Q
E
-------
R
L
LRRPPP
P
---
A
A
R
Q
R
A
S
S
K
C
K
L
M
K
----
E
EMTAADATMPLVQSDG--
G
R
H
F
L
R
R
L
A
S
W
L
L
R
R
F
-
V
Q
--
V
Q
L-----G
D
L
G
L
A
K
F
L
Y
Q
Q
E--LRVD
G
F
V
S
MN
A
I
N
TI-------GV-GSPLYA
S
P
E
QLKGNR-----CTPA
S
D
A
F
S
V
G
V
V
L
A
E
M
Y--L-------QPK
T
T
A
E
R
L
--
T
V
L
R
E
V
R
E
G
V
---
Y
RD
K
V
L
L
AQF-
P
--
E
--
L
--
K
L
V
R
R
L
T
EAQP
E
C
R
M
T
L
A
A
V
--
H
K
A
L
R
S
F
L
E
Q
A
--
L
Q
D
E
L
Y
--------------
R
HYE-----
52
Fugue
59.21
18%
-24
- C2 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
E
G
W
L
H
K
R
G
E
Y
----------
I
T
W
R
P
R
Y
F
L
L
K
N
D
G
------------
T
F
I
--------
G
Y
K
E
R
P
A
P
L
N
N
F
S
V
A
--
Q
C
Q
L
M
K
T
E
-
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
---
V
E
T
-
P
E
E
R
E
E
W
T
T
A
I
Q
R
V
T
M
N
E
-
F
E
Y
L
K
L
L
--
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
----
T
-
G
R
Y
Y
A
M
K
I
L
-
K
K
V
L
Q
N
S
R
H
P
F
L
--------------
T
A
L
K
---
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
NG
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
--
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
-
S
E
KN
V
V
Y
-----
R
D
L
K
L
E
N
L
M
L
D
K
------
D
G
H
I
K
I
T
D
F
G
L
C
------------
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
--
C
GRLPFYN
Q
D
H
E
K
L
F
E
L
--
I
L
M
E
E
I
R
F
P
R
TLG
P
E
A
K
S
L
L
S
G
L
-
L
--
K
--
K
--
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
----
H
R
F
F
A
G
I
V
W
Q
H
--
V
Y
E
K
K
L
SPPFKPQVTSETDT
R
Y
F
------
10
PsiBlast_PDB
54.39
30%
-127
- C1 -
-
3O2M
2
MK08_HUMAN
A:
[104-191]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
I
V
M
E
L
M
-
D
A
N
--
L
C
Q
V
I
Q
M
E
--
L
D
H
E
R
-----
M
S
Y
L
L
--
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
------------
K
I
L
D
F
G
L
A
R
T
A
G
T
S
F
M
M
E
P
E
V
V
T
R
Y
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
54.04
30%
-122
- C1 -
-
2G01
1
MK08_HUMAN
A:
[104-191]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
I
V
M
E
L
M
-
D
A
N
--
L
C
Q
V
I
Q
M
E
--
L
D
H
E
R
-----
M
S
Y
L
L
--
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
------------
K
I
L
D
F
G
L
A
R
T
A
G
T
S
F
M
M
E
P
E
V
V
T
R
Y
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
53.43
30%
-142
- C1 -
-
2GMX
1
MK08_HUMAN
A:
[104-191]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
I
V
M
E
L
M
-
D
A
N
--
L
C
Q
V
I
Q
M
E
--
L
D
H
E
R
-----
M
S
Y
L
L
--
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
------------
K
I
L
D
F
G
L
A
R
T
A
G
T
S
F
M
M
E
P
E
V
V
T
R
Y
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
53.24
30%
-119
- C1 -
-
2H96
1
MK08_HUMAN
A:
[104-191]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
I
V
M
E
L
M
-
D
A
N
--
L
C
Q
V
I
Q
M
E
--
L
D
H
E
R
-----
M
S
Y
L
L
--
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
------------
K
I
L
D
F
G
L
A
R
T
A
G
T
S
F
M
M
E
P
E
V
V
T
R
Y
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
52.50
30%
-107
- C1 -
-
2NO3
1
MK08_HUMAN
A:
[104-191]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
I
V
M
E
L
M
-
D
A
N
--
L
C
Q
V
I
Q
M
E
--
L
D
H
E
R
-----
M
S
Y
L
L
--
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
------------
K
I
L
D
F
G
L
A
R
T
A
G
T
S
F
M
M
E
P
E
V
V
T
R
Y
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
52.40
37%
-187
- C1 -
-
5AWM
1
JNK_DROME
A:
[124-190]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
V
M
E
L
M
-
D
A
N
--
L
C
Q
V
I
Q
M
D
--
L
D
H
D
R
-----
M
S
Y
L
L
--
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
A
D
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
51.59
11%
-18
- C1 -
-
4G3F
-
A:
[217-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
G
T
E
T
H
M
A
P
E
V
V
M
G
K
P
-----
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
--
N
-------
G
C
H
P
W
T
Q
Y
F
RG
P
L
C
L
K
I
A
S
E
P
---
P
P
I
R
E
I
P
P
S
C
-
A
P
L
T
--
A
--
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
--
R
R
K
V
G
K
A
L
Q
E
V
--
G
----------------------------
9
PsiBlast_PDB
51.37
30%
-112
- C1 -
-
3O17
-
MK08_HUMAN
A:
[104-191]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
I
V
M
E
L
M
-
D
A
N
--
L
C
Q
V
I
Q
M
E
--
L
D
H
E
R
-----
M
S
Y
L
L
--
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
------------
K
I
L
D
F
G
L
A
R
T
A
G
T
S
F
M
M
E
P
E
V
V
T
R
Y
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
51.04
11%
11
- C2 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
-
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
-
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
--
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
R
A
E
E
L
M
A
C
A
G
-------
L
T
S
P
R
I
V
P
L
---
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
----
E
L
L
E
G
-
G
S
L
G
Q
L
V
K
E
Q
G
CL
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
-
E
Y
--
L
H
S
R
RILH
G
D
V
K
A
D
N
V
L
L
S
S
D
--
G
S
H
A
A
L
C
D
F
G
H
A
V
C
L
-------
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
L
G
R
S
-----
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
-------
H
P
W
T
Q
F
F
R
G
--
P
L
C
L
K
I
A
S
E
P
---
P
P
V
R
E
I
P
P
S
C
-
A
--
P
--
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
--
G
G
K
V
N
R
A
L
Q
Q
V
GG
L
K
S
P
W
R
--------------
G
E
Y
K
E
P
RHP
23
HHSearch
50.61
14%
-33
- C1 -
-
4IDV
-
M3K14_HUMAN
A:
[233-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
G
T
E
T
H
M
A
P
E
V
V
L
G
R
S
-----
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
--
N
-------
G
C
H
P
W
T
Q
F
F
RG
P
L
C
L
K
I
A
S
E
P
---
P
P
V
R
E
I
P
P
S
C
A
P
L
-
T
--
A
--
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
--
G
G
K
V
N
R
A
L
Q
Q
V
--
G
G
---------------------------
28
HHSearch
46.52
21%
-155
- C1 -
-
4YFI
1
TNI3K_HUMAN
B:
[57-140]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
Q
L
S
E
I
E
F
H
E
I
I
G
S
G
S
F
G
K
V
Y
K
G
R
C
R
--
N
K
I
V
A
I
K
R
Y
R
---------
S
D
V
D
M
F
C
R
E
V
S
I
L
C
Q
L
N
H
P
C
V
I
Q
F
V
G
A
C
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
45.86
10%
22
- C2 -
-
5CKW
1
?
B:
[6-410]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
K
L
L
R
F
H
E
L
K
S
L
P
G
M
D
E
K
A
L
E
L
L
I
K
V
L
G
N
K
G
I
R
K
L
I
K
S
A
D
G
K
P
I
S
R
E
I
M
I
H
E
F
G
I
D
C
Q
I
L
F
I
T
T
E
A
S
L
K
P
I
I
V
P
T
E
N
K
I
S
Y
C
-----
E
Q
F
K
V
Y
A
L
D
D
G
K
T
Y
F
L
K
S
V
K
I
D
A
E
S
L
T
E
F
T
N
E
K
D
T
L
S
K
L
G
R
----
L
V
G
T
F
F
N
E
Q
T
Q
V
H
Y
I
L
T
T
F
I
-
K
G
I
--
D
L
S
R
Y
K
N
A
--
L
P
L
N
V
N
L
K
H
F
W
E
V
L
G
I
M
I
S
V
C
H
Q
V
K
Q
F
H
E
L
G
L
I
H
R
D
L
K
P
G
N
I
M
L
D
A
--------------
D
M
Q
C
H
L
V
D
F
G
S
S
S
------
S
D
K
E
P
K
P
A
S
W
--------
G
-------
T
A
S
Y
L
A
P
E
L
N
A
Q
E
D
F
I
A
-
F
S
Q
V
S
D
L
F
A
L
A
Y
S
L
D
E
L
F
N
P
F
R
Q
V
K
F
A
K
V
-
D
I
G
I
K
N
K
H
L
V
L
L
H
A
E
I
E
A
C
I
T
G
L
M
S
N
E
T
S
V
R
T
L
Y
F
S
R
I
L
Q
L
Q
R
V
P
E
S
F
-
K
S
R
P
E
A
F
T
Y
-
L
I
M
L
L
T
Q
W
K
S
C
Y
E
A
-------
P
E
M
N
K
E
L
D
E
---
I
I
A
E
I
K
V
A
Y
E
N
H
E
Q
----
D
A
V
K
I
I
T
L
L
E
Q
L
S
K
A
D
G
--
L
L
N
S
H
K
A
L
L
S
V
L
I
K
S
L
-
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
44.87
11%
24
* C2 *
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
-----------
G
I
V
-----
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
R
H
R
N
ILHL
H
E
S
F
E
S
---
M
E
E
L
V
M
I
F
E
F
I
-
S
G
L
D
I
F
E
R
I
N
T
S
A
--
F
E
L
N
E
-----
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
R
S
S
----------
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
HD
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
T
F
D
E
E
A
F
K
E
---
I
-
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
--
Q
H
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
I
R
T
L
-
K
H
R
R
Y
Y
H
T
L
-
I
K
K
D
L
N
M
V
V
--
S
A
A
-------
R
I
S
C
G
G
A
I
R
---
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
----
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
44.57
33%
-14
- C1 -
-
2A1A
-
E2AK2_HUMAN
B:
[327-422]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
---
G
F
D
Y
D
P
E
T
S
----
S
R
S
K
-----------------
T
K
C
L
F
I
Q
M
E
F
C
D
K
G
T
--
L
E
Q
W
I
E
K
R
RG
E
K
L
D
K
-----
V
L
A
L
E
L
F
E
Q
I
T
K
G
V
D
Y
I
H
S
K
K
L
I
N
R
D
L
K
P
S
N
I
F
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
43.21
11%
-27
- C2 -
-
3DZO
-
?
A:
[13-382]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
Y
F
Q
--------
G
F
R
G
T
D
P
G
D
V
V
I
E
E
L
F
N
R
I
P
Q
A
N
V
R
-
T
T
S
E
Y
A
A
D
S
L
V
S
T
S
L
W
N
T
G
Q
P
F
R
V
E
S
E
L
G
-
E
R
P
R
T
L
V
R
G
T
V
L
G
Q
E
D
P
Y
A
Y
L
E
A
T
D
Q
--
E
T
G
E
S
F
E
V
H
V
P
Y
F
T
E
R
A
I
K
Q
-
M
K
E
E
V
L
R
L
R
-
L
L
R
G
I
K
N
Q
K
Q
A
K
V
H
LRFIFPF
D
L
V
K
D
P
Q
V
L
S
R
F
F
L
Y
P
R
M
Q
S
N
L
Q
T
F
G
----
E
V
L
L
S
H
S
S
T
H
K
S
L
V
H
H
A
--
R
L
Q
L
T
L
Q
V
I
R
L
L
A
S
L
H
H
Y
G
--
L
V
H
-----
T
Y
L
R
P
V
D
I
V
L
D
Q
R
G
G
V
F
L
T
G
F
E
H
L
V
R
D
G
A
S
AVSPIGR
G
F
-
A
P
P
E
T
T
A
E
R
M
L
P
F
G
Q
HH
P
T
L
M
T
F
A
F
D
T
W
T
L
G
L
A
I
Y
W
I
W
CA
D
-------
L
P
N
T
D
D
A
A
L
--
G
G
S
E
W
I
F
R
S
C
---
K
N
-------
I
-
P
--
Q
P
V
R
--
A
L
L
E
G
F
L
R
Y
P
K
E
D
R
L
L
P
L
Q
A
M
E
T
P
E
Y
E
Q
L
R
T
E
L
--
S
A
A
L
P
L
--------------
Y
Q
-------
2
PsiBlast_PDB
42.17
38%
-67
- C1 -
-
4B6L
1
PLK3_HUMAN
A:
[84-143]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Y
I
F
L
E
L
C
S
R
K
S
--
L
A
H
I
W
K
A
R
--
H
T
L
L
E
-----
P
E
V
R
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
R
G
I
L
H
R
D
L
K
L
G
N
F
F
I
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
41.94
11%
47
- C2 -
-
1KOB
1
?
A:
[23-374]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
---
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
---------------
E
M
V
L
I
L
E
F
L
-
S
G
G
E
L
F
D
R
I
A
A
E
D
--
Y
K
M
S
E
-----
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
K
A
S
SVKIIDFGLA
T
K
L
N
P
D
E
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
R
E
P
V
--------
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
------
S
P
F
A
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
W
E
F
D
E
D
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
--
E
H
P
W
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
-
Y
N
K
I
R
Q
K
I
K
-
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
-------
R
I
A
N
---
F
S
---
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
----
S
Y
F
D
R
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
41.68
25%
-99
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[19-97]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
38.77
24%
-152
- C1 -
-
2HCK
1
HCK_HUMAN
A:
[180-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
H
T
K
V
A
V
K
T
M
K
P
G
------
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------