@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_30_2140: (2018-03-11 )
MEEYNIKRKIGDGAQGVVYEVEHRTSKTSYAMKVICCTDQEQVNMALKEIKVLLQLRHPSIVSYVDFFLVFNSVKLRREFAAQSEGACGSGGCGDGQQREARVQREQDSLFLCSLSNSEFHHGCAADSGWKQATAEASSNAPTGKPQSGAARVVPTSLLSKHRQQAGAHWLGEEEIAVCLVMELCSNGDMQGLVREARQEFMKTGSHSITEAQAVSWLEQAAAALQFIHDKGFLHRDLKPTNIFFDEYKNIKIGDFGLAATVGLGRNSAVGTPYYLAPERMLQQRYDGKVDIWGLGVVLLELLTLREQPINSMLLENPKVVDTVIPQITKMGYSTKLAALLRDMLQRQPQGRPTPSSILHRLASITATSPHPGMSATLFAGMSCPKLTEALCDVCEVEVAGVMCSSCKAAFCTGCDRARHRHHSRQSHDRTNMSSIVNSMNGASSLPLSATPMQQQQQQKTLSFSRGPSPANTSDQTRASMQNIVVFPSSSTSHSRTLPREREMNSRTFTRFQLALPGCSVSMSEYSMAQGFQGRRDGSGINAAVAETVLRVPDDVPSLAQALQVVESMPHIRKILVAGNTTHTVPLVLTSRLPDSIKLVGESPPPMLEVADSPFALHCQSGRGSVENFILRHVGRFRSKLLKLDTNLHQADANAMASAPARKPSRPTAVSITGGEWRLHKCRISCVEGSGVTVGGGKHTSSSSTNGQNTSATGTRSSRPPPSPSLVARSSLVNGVEEGAEDADVLSMEPIITKCSFIDVTAAGIVLMEKSRGLYEGNTFSGCGFAAFLLRKDATPRIRANHITDGAEAGIFCQDASGLMEYNVIAQNAGCGIVVKGASAVPVIRKNRVLSNVQAGVFCCDKAAPFVSDNEIRQNGKAGVLVKTTAAPKITRNVIESGKEAGIYVFEKGAGIIEENRIRGNQNAGLLVTTGGNPHVIHNTISKNAYEGIWVCKHGGGTFCDNDLRGNTKGAKDIEADSRVTWVGNVEQ
Atome Classification :
(20 SA)
.........10........20.-----..--.....30........-----40........50.......-.60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170......--------------------------.180.......190.......200----.-......210.......220.......230.......240...---..--.---.-250.........----260...--------.--...270.......280---.......290.......300..---------....----.310.-.-.-.-.--.-.-320-.--..--.--.-.--.-.330-------........340.......--350.......-360....--------...370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530....-----...540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEEYN
I
K
RKIGDGAQ
G
V
V
Y
E
V
E-----HR--TSKT
S
Y
A
M
K
V
I
C
CT
D
-----
Q
E
Q
V
N
M
A
L
K
E
I
K
V
L
L
QLRH-
P
S
I
V
S
Y
V
D
F
F
L
V
F
N
S
V
K
L
R
R
E
F
AAQSEGACGSGGCGD
G
Q
Q
R
E
A
R
V
Q
REQD
S
L
F
L
C
SLSNSEFHHGCAADSGWKQATAEASSNAPTGKPQSGAARV
V
P
T
S
L
L
S
K
H
R
Q
Q
AGAHWL
G
E
E
E
I
A
V
--------------------------
C
L
V
M
E
L
CSNG
D
M
Q
G
L
V
R
E
A
R
Q
E
F
M
----
K
-TGSHS
I
T
E
A
Q
A
V
S
W
L
E
Q
A
A
A
A
L
Q
F
I
HDKGFLHRDLKPT
N
I
F
F
---
D
E--Y---K-N--
I
K
IGDFG
L
A
----
A
T
VGLG--------R--NSAVGT
P
Y
YL
A
P
E
R
M
L
---
Q
Q
R
YDGKV
D
I
W
G
L
G
V
V
L
L
E
L
L
T
---------
L
R
EQ----P
I
N
S
M
-L-L-E-N--P-
K
-
V
-
V
-
D
--
T
V
--
I
--
P
-
Q
--
I
-
T
KM--------GY
S
T
K
L
A
A
L
L
R
D
M
L
Q
RQP--QGRP
T
P
S
S
I
L
-
H
R
L
A
S
I
T--------ATSPHPGM
S
A
T
L
F
AGMS
C
P
K
L
T
E
A
L
C
D
V
C
E
V
E
V
A
G
V
M
C
S
S
C
K
A
A
F
CT
G
C
D
R
A
R
H
RHHSRQSHDRT
N
M
S
S
I
V
N
SMNGASSLPLSAT
P
M
Q
Q
Q
Q
Q
Q
K
TLSFSRGPSPANT
S
D
Q
T
R
ASM
Q
N
I
V
V
FPSSSTSHSRTLPREREMNSR
T
F
T
R
F
Q
L
ALPGCSV
S
M
S
E
Y
S
M
A
QGFQGRR-----DGSG
I
N
A
A
V
A
E
T
V
L
RVPD
D
V
P
S
L
A
Q
A
L
Q
V
V
E
S
M
P
H
I
R
K
I
LVAGNTT
H
T
V
P
L
V
L
TSRLPD
S
I
K
LVGESPP
P
M
L
E
VADS
P
F
A
L
H
CQSGR
G
S
V
E
N
F
I
L
R
H
V
G
R
F
R
S
K
L
L
K
LDTNLHQA
D
A
N
A
MASAPARKPSRP
T
A
V
S
ITGG
E
W
R
L
H
K
C
R
I
S
C
VEGS
G
V
T
VGGGKHTSSSSTNGQNTSATGTRSSRPPP
S
P
S
L
V
A
R
S
S
L
V
N
G
V
E
EGAEDADVLSMEPIITK
C
S
F
I
D
VTAA
G
I
V
L
M
EKSRGLYEGNTFS
G
C
G
F
A
A
F
L
L
RKDATP
R
I
RANHITDGAEA
G
I
F
CQDASG
L
M
E
Y
N
V
I
A
QNAG
C
G
I
V
V
KGASAV
P
V
IRK
N
R
V
L
S
NVQA
G
V
F
C
CDKAAPFVSD
N
E
I
RQNGKA
G
V
L
V
K
TTAA
P
K
I
T
R
N
V
I
ESGKEA
G
I
Y
V
F
EKGAGI
I
E
ENRIRGNQNA
G
L
L
V
TTGGNP
H
V
I
H
NTISKNAYE
G
I
W
V
C
KHGGGTFCDNDLRGNTKGAKDIEADS
R
V
T
W
VGNVEQ
37
HHSearch
79.18
22%
-100
- C2 -
-
4Y95
4
?
A:
[7-262]
-
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
-----
W
R
--
G
-
Q
Y
D
V
A
I
K
M
I
K
E
G
S
-----
M
-
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
-
E
K
L
V
Q
L
Y
G
V
C
T
K
--------------------------------------------------------------------------------------------------------
Q
R
P
I
--------------------------
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
-------------
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
---
N
D
--
Q
---
G
-
V
--
V
K
V
S
D
F
G
M
T
----
R
F
V
L
D
D
EYTS----
S
--
T
G
T
K
F
P
V
K
W
A
S
P
E
V
L
M
---
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L--------
G
K
-
M
----
P
Y
E
R
F
T
N
-
S
-
E
-
T
--
A
E
H
-
I
-
A
-
Q
--
G
L
--
R
--
L
-
P
--
R
--
P
H
--------
L
A
S
E
R
V
Y
A
I
M
Y
S
C
W
H
E
K
A
--
D
E
R
P
T
F
K
I
L
L
-
S
N
I
L
D
V
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
78.07
27%
-82
- C2 -
-
5J5T
1
M4K3_HUMAN
A:
[4-263]
-
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
-----
N
V
--
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
-----
G
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
H
-
P
N
I
V
A
Y
F
G
S
Y
L
R
--------------------------------------------------------------------------------------------------------
R
D
K
L
--------------------------
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
--------------
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
---
T
D
--
N
---
G
-
H
--
V
K
L
A
D
F
G
V
S
----
A
Q
I
T
A
T
IA----------
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
ER
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
---------
L
Q
P
P
----
M
F
D
L
H
-
P
-
M
-
R
-
A
--
L
F
L
-
M
-
T
-
K
S-
N
F
--
Q
P
-
P
-
K
--
L
K
D
K
M
--------
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
--
K
K
R
P
T
A
E
K
L
L
-
Q
H
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
77.68
24%
-90
- C2 -
-
4TWP
1
ABL1_HUMAN
B:
[8-265]
-
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-----
W
K
--
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
------
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
--------------------------------------------------------------------------------------------------------
E
P
P
F
--------------------------
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------------
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
--
N
---
H
-
L
--
V
K
V
A
D
F
G
L
S
----
R
L
M
T
G
D
T
Y
T
A
----
H
--
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
---------
Y
G
M
S
----
P
Y
P
G
I
-
D
-
L
-
S
Q
V
--
Y
-
E
-
L
-
L
-
E
--
K
D
--
Y
--
R
-
M
--
E
-
R
P
E
--------
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
--
S
D
R
P
S
F
A
E
I
H
-
Q
A
F
E
T
M
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
77.66
22%
-86
- C2 -
-
5T18
1
A:
[8-263]
-
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
-----
W
R
---
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
-----
M
-
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
-
E
K
L
V
Q
L
Y
G
V
C
T
K
--------------------------------------------------------------------------------------------------------
Q
R
P
I
--------------------------
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-----------------
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
---
N
D
--
Q
---
G
-
V
--
V
K
V
S
D
F
G
L
S
----
R
Y
V
L
D
D
EYTS----
S
--
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
---
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L--------
G
K
M
-----
P
Y
E
R
F
-
T
N
S
-
E
-
T
--
A
-
E
-
H
-
I
-
A
--
Q
G
--
L
--
R
-
L
--
Y
-
R
P
H
--------
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
--
D
E
R
P
T
F
K
I
L
L
-
S
N
I
L
D
V
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
77.35
22%
-69
- C2 -
-
4IDV
1
M3K14_HUMAN
A:
[75-332]
--
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
-----
D
K
--
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
----------
F
R
A
E
E
L
M
A
C
A
G
L
T
S
-
P
R
I
V
P
L
Y
G
A
V
R
E
--------------------------------------------------------------------------------------------------------
G
P
W
V
--------------------------
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
--------------
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
---
S
S
--
D
---
G
S
H
--
A
A
L
C
D
F
G
H
A
----
V
C
L
Q
P
D
GLGKSLLT
G
--
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
L
---
G
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
---------
G
C
H
P
-----
W
T
Q
F
-
F
-
R
-
G
-
P
L
C
L
-
K
-
I
-
A
-
S
--
E
P
--
P
--
P
V
R
--
E
-
I
P
P
--------
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
--
I
H
R
V
S
A
A
E
L
G
-
G
K
V
N
R
A
L
--------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
75.47
21%
-82
- C2 -
-
4G3F
1
A:
[58-316]
-
H
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
-----
D
K
--
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
----------
F
R
V
E
E
L
V
A
C
A
G
L
S
S
-
P
R
I
V
P
L
Y
G
A
V
R
E
--------------------------------------------------------------------------------------------------------
G
P
W
V
--------------------------
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
--------------
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
---
S
S
--
D
---
G
S
R
--
A
A
L
C
D
F
G
H
A
----
L
C
L
--------------
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
---
G
K
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
---------
G
C
H
P
-----
W
T
Q
Y
-
F
-
R
-
G
-
P
L
C
L
-
K
-
I
-
A
-
S
--
E
P
--
P
--
P
I
R
--
E
-
I
P
P
--------
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
--
V
H
R
A
S
A
M
E
L
R
-
R
K
V
G
K
A
L
--------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
75.35
28%
-79
- C2 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[95-344]
--
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
-----
V
R
--
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
-
E
N
V
V
E
M
Y
N
S
Y
L
V
--------------------------------------------------------------------------------------------------------
G
D
E
L
--------------------------
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
---------------
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
---
T
H
--
D
---
G
-
R
--
V
K
L
S
D
F
G
F
C
----
A
Q
V
S
K
E
VPR-----
R
--
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
---
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
---------
G
E
P
P
----
Y
F
N
E
P
-
P
-
L
-
K
-
A
--
M
-
K
-
M
-
I
-
R
--
D
N
--
L
P-
P
-
R
--
L
K
N
L
H
--------
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
--
A
Q
R
A
T
A
A
E
L
L
-
K
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
74.97
26%
-89
- C2 -
-
5DA3
3
PTK6_HUMAN
A:
[6-262]
-
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
-----
W
K
---
D
R
V
Q
V
A
I
K
V
I
S
R
D
N
-----
L
L
H
-
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
-
K
H
I
L
A
L
Y
A
V
V
S
V
--------------------------------------------------------------------------------------------------------
G
D
P
V
--------------------------
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
------------
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
---
G
E
--
N
---
T
-
L
--
C
K
V
G
D
F
G
L
A
----
R
L
I
K
E
D
V
Y
L
-----
S
--
H
D
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
---
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
---------
R
G
Q
V
----
P
Y
P
G
M
-
S
-
N
-
H
-
E
--
A
F
L
-
R
-
V
-
D
--
A
G
--
Y
--
R
-
M
--
P
-
C
P
L
--------
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
--
E
Q
R
P
T
F
K
A
L
R
-
E
R
L
S
S
F
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
74.09
24%
-90
- C2 -
-
1TKI
-
TITIN_HUMAN
A:
[21-275]
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
-----
E
T
--
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
R
H
-
R
N
I
L
H
L
H
E
S
F
E
S
--------------------------------------------------------------------------------------------------------
M
E
E
L
--------------------------
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
-------------
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
---
Q
T
RR
S
---
S
-
T
--
I
K
I
I
E
F
G
Q
A
----
R
Q
L
K
P
G
D
N
------
F
--
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
---
H
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
---------
G
I
N
P
----
F
L
A
E
T
-
N
-
Q
-
Q
-
I
--
I
E
N
-
I
-
M
-
N
--
A
E
--
Y
TF
D
-
E
--
E
-
A
F
K
--------
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
--
K
S
R
M
T
A
S
E
A
L
-
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
73.86
25%
-100
- C2 -
-
2X4F
4
MYLK4_HUMAN
A:
[90-344]
--
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
-----
E
T
--
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
-----
M
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
D
H
-
A
N
L
I
Q
L
Y
D
A
F
E
S
--------------------------------------------------------------------------------------------------------
K
N
D
I
--------------------------
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
-------------
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
VN-
R
D
--
A
---
K
-
Q
--
I
K
I
I
D
F
G
L
A
----
R
R
Y
K
P
R
E
K
------
L
--
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
---
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
---------
G
L
S
P
----
F
L
G
D
N
-
D
-
A
-
E
-
T
--
L
N
N
-
I
-
L
-
A
CR
W
D
--
L
--
E
-
D
--
E
-
E
F
Q
--------
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
--
S
W
R
I
S
A
S
E
A
L
-
K
H
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
70.74
13%
-
- C2 -
-
3QA8
-
?
A:
[16-666]
--------------------------------------------------------------------------------------------------------------------------------------------
E
M
K
E
R
L
G
T
G
G
F
G
Y
V
L
R
W
I
H
Q
D
T
G
E
Q
V
A
I
K
Q
C
R
Q
E
L
S
P
K
N
R
E
R
W
C
L
E
I
Q
I
M
K
K
L
NHPN
V
V
S
A
REVPDGLQKLAPND
L
P
L
L
A
M
E
Y
C
E
G
G
D
L
R
K
Y
L
N
Q
F
E
N
-----------
C
C
G
L
K
E
G
P
I
R
T
L
L
S
D
I
S
S
A
L
R
Y
L
H
E
N
R
I
I
H
R
D
L
K
P
E
N
I
V
L
QPG
P
Q
--
R
---
L
-
I
--
H
K
I
I
D
L
G
Y
A
----
K
E
L
D
Q
G
--------
E
LC
T
E
F
V
G
T
L
Q
Y
L
A
P
E
L
L
E
---
Q
K
K
Y
T
V
T
V
D
Y
W
S
F
G
T
L
A
F
E
C
I
T
GFRPFLPNW
Q
P
V
Q
----
W
H
G
K
V
-
R
-
I
-
V
-
V
--
Y
-
D
-
D
-
L
-
T
--
G
A
--
V
--
K
-
F
--
S
-
S
V
L
PTPNHLS
G
I
L
A
G
K
L
E
R
W
L
Q
C
M
L
M
W
H
Q
RT
D
P
Q
N
P
N
V
G
C
F
-
Q
A
L
D
S
I
L
S
L
K
L
L
S
V
M
N
M
V
S
G
R
V
H
T
Y
P
V
T
E
N
E
N
L
Q
N
L
K
S
W
L
Q
Q
D
T
G
I
P
E
E
E
Q
E
L
L
Q
A
S
G
L
A
L
N
S
A
Q
P
L
T
Q
Y
V
I
D
C
T
V
G
D
L
I
F
L
F
D
--
N
R
K
I
S
L
P
A
H
P
E
S
V
S
I
V
L
Q
D
P
K
R
P
L
T
Y
T
H
L
R
R
V
W
G
Q
I
W
Q
T
I
R
A
L
K
E
D
C
A
R
L
L
Q
G
Q
R
T
S
M
V
N
L
L
R
Y
N
T
E
L
S
K
K
K
N
S
M
T
S
E
C
E
Q
L
K
A
K
L
D
F
F
R
S
S
I
Q
I
D
L
E
K
Y
S
E
QM
E
F
G
I
T
S
E
K
L
L
S
A
W
R
E
M
E
Q
A
V
E
L
C
G
R
E
R
E
V
Q
A
L
V
D
K
M
M
A
L
Q
T
D
S
V
D
L
Q
R
N
P
-
T
L
D
D
L
E
E
Q
A
R
D
L
Y
R
R
L
R
E
R
P
R
D
Q
R
T
P
G
D
S
N
D
M
V
R
L
L
I
L
A
I
Q
S
F
E
K
R
V
I
L
I
Y
D
Q
L
S
K
T
V
V
C
K
R
K
A
L
E
L
S
P
K
V
K
E
V
M
N
L
M
R
E
D
E
K
I
V
V
R
R
Q
E
K
R
Q
Q
E
L
W
N
L
L
K
I
A
C
S
K
V
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
69.54
25%
-48
- C2 -
-
3CBL
3
A:
[114-373]
-
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
-----
L
R
--
A
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P----
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
-
P
N
I
V
R
L
I
G
V
C
T
Q
--------------------------------------------------------------------------------------------------------
K
Q
P
I
--------------------------
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
-------------
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
E
--
K
---
N
-
V
--
L
K
I
S
D
F
G
M
S
----
R
E
E
A
D
G
VYAAS---
G
--
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
---
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
---------
L
G
A
S
----
P
Y
P
N
L
-
S
-
N
Q
Q
-
T
--
R
-
E
-
F
-
V
-
E
--
K
G
--
G
--
R
-
L
--
P
-
C
P
E
--------
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
--
G
Q
R
P
S
F
S
T
I
Y
-
Q
E
L
Q
S
I
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
69.05
25%
-20
- C2 -
-
3C0G
1
CSKP_HUMAN
B:
[24-287]
-
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
-----
N
R
--
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
--------------------------------------------------------------------------------------------------------
D
G
M
L
--------------------------
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
----------
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
---
A
S
--
K
ENS
A
-
P
--
V
K
L
G
G
F
G
V
A
----
I
Q
L
G
E
S
G
L
V
-----
A
--
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
---
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
---------
G
C
L
P
----
F
Y
G
T
K
-
E
-
R
-
L
-
F
--
E
-
G
-
I
-
I
-
K
--
G
K
--
Y
--
K
-
M
NP
R
-
Q
W
S
--------
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
--
A
E
R
I
T
V
Y
E
A
L
-
N
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
68.85
25%
-27
- C2 -
-
3C0I
1
CSKP_HUMAN
A:
[24-287]
-
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
-----
N
R
--
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
--------------------------------------------------------------------------------------------------------
D
G
M
L
--------------------------
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
----------
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
---
A
S
--
K
ENS
A
-
P
--
V
K
L
G
G
F
G
V
A
----
I
Q
L
G
E
S
GLV-----
A
--
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
---
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
---------
G
C
L
P
----
F
Y
G
T
K
-
E
-
R
-
L
-
F
--
E
-
G
-
I
-
I
-
K
--
G
K
--
Y
--
K
-
M
N
P
R
-
Q
W
S
--------
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
--
A
E
R
I
T
V
Y
E
A
L
-
N
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
68.41
24%
-25
- C2 -
-
4AT5
2
A:
[13-289]
-
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
-----
C
Y
NL--
K
I
L
V
A
V
K
T
L
K
D
A
S
-----
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
-
E
H
I
V
K
F
Y
G
V
C
V
E
--------------------------------------------------------------------------------------------------------
G
D
P
L
--------------------------
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
AE
G
-
N
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
--
N
---
L
-
L
--
V
K
I
G
D
F
G
M
S
----
R
D
V
Y
S
T
DYYRV---
G
--
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
---
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
---------
Y
G
K
Q
----
P
W
Y
Q
L
-
S
-
N
-
N
-
E
V
-
I
-
E
C
I
-
T
-
Q
--
G
R
--
V
--
L
-
Q
--
R
--
P
R
--------
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
--
H
M
R
K
N
I
K
G
I
H
-
T
L
L
Q
N
L
A
--------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
67.45
25%
-47
* C2 *
-
3BKB
7
A:
[114-373]
-
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
-----
L
R
--
A
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P----
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
-
P
N
I
V
R
L
I
G
V
C
T
Q
--------------------------------------------------------------------------------------------------------
K
Q
P
I
--------------------------
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
-------------
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
E
--
K
---
N
-
V
--
L
K
I
S
D
F
G
M
S
----
R
E
E
A
D
G
V
Y
A
A
S---
G
--
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
---
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
---------
L
G
A
S
----
P
Y
P
N
L
-
S
-
N
Q
Q
-
T
--
R
-
E
-
F
-
V
-
E
--
K
G
--
G
--
R
-
L
--
P
-
C
P
E
--------
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
--
G
Q
R
P
S
F
S
T
I
Y
-
Q
E
L
Q
S
I
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
67.15
20%
-45
- C2 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
----------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
---
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
E
L
--------------------------
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
-------------
S
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
---
Q
T
--
R
---
R
-
S
ST
I
K
I
I
E
F
G
Q
A
----
R
Q
L
K
P
G
D
N
------
F
--
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
---
H
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
GINPFLAE-
T
N
Q
Q
----
I
I
E
N
I
-
M
-
N
-
A
-
E
--
Y
-
T
-
F
-
D
-
E
--
E
A
--
F
--
K
-
E
--
I
--------------
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
--
K
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
--------
I
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
--
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
65.25
22%
5
- C2 -
-
4ASE
1
A:
[64-347]
-
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
GID
K
T
--
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T----
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
-------------------------------------------------------------------------------------------------------
P
G
G
P
L
--------------------------
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
----
P
Y-
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
---
S
E
--
K
---
N
-
V
--
V
K
I
C
D
F
G
L
A
----
R
D
I
Y
K
D
PD
Y
V
R
---
K
--
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
---
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
---------
L
G
A
S
----
P
Y
P
G
V
-
K
-
I
-
D
-
E
E
F
C
-
R
-
R
-
L
K
E
--
G
T
--
R
--
M
-
R
--
A
--
P
D
--------
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
--
S
Q
R
P
T
F
S
E
L
V
-
E
H
L
G
N
L
L
--------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
64.83
27%
6
- C2 -
-
2WEL
7
KCC2D_HUMAN
A:
[4-266]
-
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
-----
K
I
--
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
LS---
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--------------------------------------------------------------------------------------------------------
E
G
F
H
--------------------------
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--------------
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
--
K
SKG
A
-
A
--
V
K
L
A
D
F
G
L
A
----
I
E
V
Q
G
D
QQA-----
W
--
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
---
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
---------
G
Y
P
P
----
F
W
D
E
D
-
Q
-
H
-
R
-
L
--
Y
-
Q
-
Q
I
K
-
A
--
G
A
YD
F
--
P
-
S
--
P
-
E
W
D
--------
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
--
A
K
R
I
T
A
S
E
A
L
-
K
H
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
63.12
32%
-65
- C2 -
-
4APC
-
NEK1_HUMAN
A:
[93-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
N
G
S
L
--------------------------
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
Q
K
G
V
L
F
----
Q
--------
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
---
T
K
--
D
---
G
-
T
--
V
Q
L
G
D
F
G
I
A
RVLN
S
T
V
E
L
A
--------
R
---
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
---
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
---------
L
K
H
A
FEAG
S
M
K
N
L
-
V
-
L
--------
K
-
I
-
I
-
S
--
G
S
--
F
--
P
-
P
--
V
-
S
-
L
--------
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
--
R
D
R
P
S
V
N
S
I
L
-
E
K
--
G
F
I
--------
A
K
R
I
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------