@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_30_3090: (2018-03-11 )
MLWADFGPPLHNFSGSDGQAAMGPILFAEATTVHYRGSVYHGLTEEMLQRGGSTFSIQVSIPTFPTNITLVRSIMMSILTSNVRLVDDAGTFVRRMQPAAQGEAAAHAFNHTKAWLTWRRFVKDILSHSEIEVSPNGHAVKVRFASGKWVLPAQTSALIVPCLPFSLFEQLGRLGVQDLPNNCLAGDPFFVSKKSFLQLDEARWNPSQQVLVTGGPISIPLAGTSSTVSDKAELERRLRVMEGYTCLHTRSAFVRGSRWDVRGSVYRFTPHRGGMQTLCYVPYPDTLPFLSVKLMDSYEVAGPEGVSTDPPQVHADLEFSGTIYGTNLTERDTVVITDELCADFTSQNVFFVDLFFSSSSRVSFFGTFHKRGIYHVCYHREGSPMYVLVSTLLVERGADVVIDNDSPNVLIDQDVKLLQSASVSRLNVQDKGNLNLRQRSLNVSYFLWSGGSISGRGTINCTGYAKITTQGYETRLLSVPLYNYGEMTIDVQRLSMERDGAIHNYGNLTLAVSSMGVDSISSVLSAGRRNAITNYPGGVIRIMALDERSYALLTGRFIFQGGSVLLLGKINLTDASSFADSTVTLKSGTLLTTHKMHLGGAVVVEERSVLTLMKGCVFVSATVSGDGVVRLLGDDVVLNSLTVTGSIRALFGVGMTDPISVIAYGTTHFGEDTLVHVTNANFVTSSGLAKVTFLGRLLADFVTVRFTGNMILQIGGVAALYGNMSGEALNFRRTLTKLSGYSLPLAMASFVSRNATMFVIDTFRLDEAVDASARGGSSTAKGIVSSLDPFNKSIFSGPAAVETQACEVYLPTSQRLTVSGRLVLRGCVQVPAGGTISGAVVKLEDSADWELLHQTFCIFADPETLPHLCRHNRRSVPPLRSGLALSEKVYVRSPASFLLDELTLVHSHTRVTESVPITIKDTIIVRVGSTLVLAYGIVMAARHIIIEGTLVVNDPRNTVLKGLVEVKEEGIIELRGVSGMSCANELLVEGRLYLAPNARGFHFRCLSASDDDIGGEDSEAAPADPEGGETMKPMGRLDALLRKRALANLRPDMTCPDDVVHDYDSRRQFINLYWMRQAYDPPADQPTRRDMIWMTLFGIACCFGTFHILLTMWGYTYKKWWSDIRTPCPLQLTLTWDELSYSAVNYFSFCRFIIIHLLNTMAAFHPGLPAPLPSVAGMLLRGMGLLMPHHQTPISRPRKVGILYIVWLFTFLYVKKRGSWLISYLRRRHPYLLDVVQKLYTVLTILNFIFLAPLMSSVVDAIAWPTLLRNVPTYELMQQDIWVAISIISFLSMGVMAPSSILTNQMFIPHMDLRVRASNMFVHFAAQMWETVMWKVFYNNPMCVVFNCIFFQFIRLAFLLCFPATPYKNVNRFMMFLLMQPFLVYLAIILYVVLVRTGVYTSCTQGTDLFRVVAAAFVISLFVNFWRNVLFTQEQTTATGDVSIDALRCSMTQIRNRIHDLKFEVYACTDAMERENILNAIARMRIEYLEKQERYRFETHRILRPFFFSGTGFDGDTHLQSHSSVASYSNDDGDDASNVHPAMSPNMQQGTLLSVEEMETFSCGPALGKGSYGTVHLGILTNGKMVAVKYVNVVSESPEALASVEAEVNMLRELSHPNIIRYFGAHTIQDTMLVFMEFAVGGSLTSIVKKFTHLTEPVMQLYTFQILKGLQYLHDKGVVHRDIKGENILIDGYGVAKLADFGCSKSLANIANSSQVGCGTLVGSPFWMAPEVIRSEAYGTKADIWSVGCTVVEMLNGGEPPWREEFDNVYSAMFYVGSTNDIPQIPAETSDPCRDFLFRCFERDVMKRASADELLQHPWLKSAAAASHAEDSSDNFLSFSTVSSPSLKSAYDGHRTAGFSRSTPHSSREDLTSPLNGSTAPQPPNGSIASITSNASKKFK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......-1580.......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690..---....1700.......1710......1720......1730......1740......1750......1760......1770......1780..--....1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLWADFGPPLHNFSGSDGQAAMG
P
I
L
F
A
E
A
T
T
V
H
YR
G
S
V
YH
G
L
T
E
E
M
L
Q
RGG
S
T
F
S
I
Q
V
SIPTFP
T
N
I
T
L
V
R
S
I
M
M
S
I
L
TSN
V
R
L
VDD
A
G
T
F
V
R
R
MQPAAQG
E
A
A
A
H
A
FN
H
T
K
A
W
L
T
W
R
R
F
V
K
D
I
LSHS
E
I
E
VSPNG
H
A
V
K
V
R
FASG
K
W
V
L
PAQT
S
A
L
I
V
PCL
P
F
S
L
F
E
Q
L
G
RLG
V
Q
DLPNNCLAGDP
F
F
VS
K
K
S
F
L
Q
L
D
EARWNPS
Q
Q
V
L
V
TGG
P
I
S
I
P
LAGTSSTVS
D
K
A
E
L
E
R
R
L
R
V
MEG
Y
T
C
LHT
R
S
A
FVRGSRWDVRG
S
V
Y
R
FTPHRGG
M
Q
T
L
C
Y
VPYPDTLP
F
L
S
V
K
L
M
DSYEVAGPEGVSTDPP
Q
V
H
A
D
L
E
FS
G
T
I
YGTNLTER
D
T
V
V
I
T
D
E
L
C
A
DFTSQ
N
V
F
F
V
D
L
F
FSSS
S
R
V
S
F
F
G
T
F
HKR
G
I
Y
H
V
C
Y
HREGS
P
M
Y
V
L
V
S
T
L
L
V
ERGA
D
V
V
I
DNDSP
N
V
L
I
D
Q
D
V
K
L
L
Q
SASV
S
R
L
N
VQDKGN
L
N
L
R
Q
RSL
N
V
S
Y
F
L
WSGGSISGR
G
T
I
N
CT
G
Y
A
K
I
TTQGY
E
T
R
L
L
S
V
PLYNYG
E
M
T
I
D
V
Q
R
L
SMERDGAIHNYG
N
L
T
L
A
V
SSM
G
V
D
S
I
S
S
V
L
SAGRRNAITNYPG
G
V
I
R
I
M
A
LDER
S
Y
A
L
L
T
G
R
F
I
FQGG
S
V
L
L
L
G
K
I
NLTDASSFAD
S
T
V
T
LKS
G
T
L
L
T
T
H
K
MHLG
G
A
V
V
V
EE
R
S
V
L
T
L
MKG
C
V
F
V
S
A
T
VSG
D
G
V
V
R
LLGDD
V
V
L
N
S
L
T
VTG
S
I
R
A
L
FGVGMTD
P
I
S
V
I
A
YGTTHFGE
D
T
L
V
H
V
TNA
N
F
VTSSG
L
A
K
V
T
F
L
G
R
L
L
A
D
F
V
T
V
R
FTG
N
M
I
L
Q
IG
G
V
A
A
L
YGNMSGE
A
L
N
F
R
R
T
L
T
K
LSGYS
L
P
L
A
M
A
S
F
V
SRN
A
T
M
F
V
I
D
TFRLDEAVDASARGGS
S
T
A
K
G
I
V
S
SLDPF
N
K
SIFSGPAAVET
Q
A
C
E
V
Y
LPTS
Q
R
L
T
VS
G
R
L
V
L
R
G
C
V
QVPAGGTI
S
G
A
V
V
K
LEDSA
D
W
E
L
L
H
Q
T
F
C
I
FADP
E
T
L
P
H
L
C
R
HNRRSVPPLRSGLALS
E
K
V
Y
VR
S
P
A
S
F
L
L
D
E
L
T
L
V
HSHTRVTESV
P
I
T
I
K
D
T
I
I
V
RVG
S
T
L
V
L
A
Y
G
I
V
M
A
A
R
H
I
I
I
E
G
T
L
V
V
NDP
R
N
T
V
L
K
G
L
V
E
V
K
EE
G
I
I
E
L
RGVSG
M
S
C
A
N
E
L
L
VEG
R
L
Y
LAPNAR
G
F
H
F
R
CLSASDDDIGGEDSEAAPADPEGGETMK
P
M
G
R
L
D
A
L
L
R
K
R
A
L
A
NLRPDMTC
P
D
D
V
V
H
D
Y
D
S
R
R
Q
F
I
N
L
Y
W
M
R
QAYDPPADQPTRR
D
M
I
W
M
T
L
F
G
I
A
C
C
F
G
T
F
H
I
L
L
T
M
WG
Y
T
Y
K
K
W
W
S
DIRTPC
P
L
Q
L
T
L
TWDEL
S
Y
S
A
V
N
Y
F
S
F
C
R
F
I
I
I
H
L
L
N
T
M
A
A
FHPGLPA
P
L
P
S
V
A
G
M
L
L
R
G
M
G
LLMPHHQTPISRP
R
K
V
G
I
L
Y
I
V
W
L
F
T
F
L
Y
V
KKR
G
S
W
L
I
S
Y
L
R
RRH
P
Y
L
L
D
V
V
Q
K
L
Y
T
V
L
T
I
L
N
F
I
F
L
A
P
L
M
S
S
V
V
D
A
I
A
W
P
T
L
LRNV
P
T
Y
E
L
M
Q
Q
D
I
W
V
A
I
S
I
I
S
F
L
S
M
G
VMA
P
S
S
I
LTNQMFIPHM
D
L
R
V
R
AS
N
M
F
V
H
F
A
A
Q
M
W
E
T
V
M
W
K
V
FYNN
P
M
C
V
V
F
N
C
I
F
F
Q
F
I
R
L
A
F
L
L
CFPATP
Y
K
N
V
N
R
F
M
M
F
L
L
M
Q
P
F
L
V
Y
L
A
I
I
L
Y
V
V
L
V
RTGVYTSCTQ
G
T
D
L
F
R
V
V
A
A
A
F
V
I
S
L
F
V
N
F
W
R
N
V
LFTQEQTTATG
D
V
S
I
D
A
L
R
C
S
M
T
Q
I
R
N
R
I
HD
L
K
F
E
V
Y
A
CT
D
A
M
E
R
E
N
I
L
N
A
I
A
R
M
R
I
E
Y
L
E
K
Q
E
R
Y
R
F
E
T
H
R
I
L
R
P
F
F
FSGTGFDGDT
H
L
Q
SHSSVASYSNDDGDDASNVHPAMSPNMQQ
G
T
L
L
S
V
E
E
METFSCGPALGKGSY
G
T
V
H
L
G
I
-LT-N
G
K
M
V
A
V
K
Y
V
N
V
VSES
P
E
A
L
A
S
V
E
A
E
V
N
M
L
R
E
LSHP
N
I
I
R
Y
FGAH
T
I
Q
D
T
M
L
V
F
M
E
F
AVG
G
S
L
T
S
I
V
K
K
F
T
H
L
T
E
P
V
M
Q
L
Y
T
F
Q
I
L
K
G
L
Q
Y
L
H
DKGV
V
H
RDIKG
E
N
I
L
IDGYG
V
---
A
K
L
A
DFG-C
S
K
S
L
A
N
IANSSQVGCGTLVGSPFWM
A
P
E
V
I
R
SEAYGTKA
D
I
W
S
V
G
C
T
V
V
E
M
LNGGEP
P
W
R
E
E
F
D
N
V
Y
S
A
M
F
Y
VGSTNDIPQI--PAETSD
P
C
R
D
F
L
F
R
C
F
E
R
D
V
M
K
RA
S
A
D
E
L
L
Q
H
PWL
K
S
A
AAASHAEDSSD
N
F
L
S
F
STVSSPS
L
K
S
AYDGHRTAGFSRSTPHSS
R
E
DLTSPLNGSTAPQPPNG
S
I
A
S
ITSNASKKFK
13
PsiBlast_PDB
81.36
39%
-35
- C1 -
-
4DAW
-
PAK1_HUMAN
A:
[28-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
-----
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
12
PsiBlast_PDB
80.07
39%
-35
- C1 -
-
3FY0
1
PAK1_HUMAN
A:
[28-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
-----
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
14
PsiBlast_PDB
79.35
39%
-35
- C1 -
-
5DFP
2
PAK1_HUMAN
A:
[28-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
-----
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
7
PsiBlast_PDB
78.21
39%
-35
- C1 -
-
1YHW
-
PAK1_HUMAN
A:
[276-528]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
-----
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
11
PsiBlast_PDB
78.18
39%
-37
- C1 -
-
3FXZ
1
?
A:
[28-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
-----
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
15
PsiBlast_PDB
77.94
39%
-36
- C1 -
-
4O0R
1
PAK1_HUMAN
A:
[28-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
-----
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
10
PsiBlast_PDB
76.97
39%
-33
- C1 -
-
4EQC
1
PAK1_HUMAN
A:
[32-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
-----
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
6
PsiBlast_PDB
76.61
39%
0
- C- -
-
1F3M
-
?
C:
[28-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
-----
I
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
16
PsiBlast_PDB
75.92
39%
-35
- C1 -
-
4O0T
1
PAK1_HUMAN
A:
[28-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
-----
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
2
PsiBlast_PDB
75.45
40%
-50
- C1 -
-
4ZJJ
1
PAK1_HUMAN
A:
[30-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
----
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
8
PsiBlast_PDB
74.79
39%
-33
- C1 -
-
5DEY
1
PAK1_HUMAN
A:
[28-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
-----
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
18
PsiBlast_PDB
73.97
38%
-37
- C1 -
-
1YHV
-
?
A:
[276-528]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
-----
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
20
PsiBlast_PDB
73.43
38%
-36
- C1 -
-
3Q4Z
1
PAK1_HUMAN
A:
[29-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D-----
Q
E
V
A
I
R
Q
M
N
L
-----
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
-----
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
17
PsiBlast_PDB
73.15
39%
-33
- C1 -
-
5IME
1
PAK1_HUMAN
A:
[28-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D-----
Q
E
V
A
I
K
Q
M
N
L
-----
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
-----
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
9
PsiBlast_PDB
72.31
39%
-33
- C1 -
-
5DEW
1
PAK1_HUMAN
A:
[28-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
-----
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
1
PsiBlast_PDB
71.38
40%
-44
- C1 -
-
4ZJI
1
PAK1_HUMAN
A:
[30-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
Q
M
N
L
-----
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
-----------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
4
PsiBlast_PDB
69.45
39%
-32
- C1 -
-
4ZY5
1
PAK1_HUMAN
A:
[29-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
-----
Q
Q
P
K
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
---
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
-----
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
5
PsiBlast_PDB
69.35
39%
-38
- C1 -
-
4ZY6
1
PAK1_HUMAN
A:
[29-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
------
Q
P
K
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
-----
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
3
PsiBlast_PDB
66.60
39%
-31
- C1 -
-
4ZY4
1
PAK1_HUMAN
A:
[29-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
-----
Q
Q
P
K
K
E
L
--
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
-----
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
-
A
T
N
G
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
-------------------------------------------------------------------------
46
HHSearch
66.32
25%
-40
- C1 -
-
3KK8
-
KCC2D_CAEEL
A:
[6-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
-
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
A
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
A
K
GAA
V
K
L
A
D
F
G
-
L
A
I
E
V
N
D
S
E
-----
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
D
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
A
Q
I
K
-
A
G
A
Y
D
Y
P
S
P
E
--
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
E
R
V
A
-------------------------------------------------------------------------