@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_31_1880: (2018-03-12 )
MRLQSSRLSSGATAPKQLHRDVPSPGRPVKTRMRCRFAVLKYFLLRVDVSVSIVYLLVLLCVAVPIVVVSQVYLTRMLVASWRTVHNTRVYYITERISISTISVRDIANGFMALNIPGGGSYGDHDLMENLCSSLDNYDKLTRFRALSLVSLETESAISCIHGIPTMDSMRTLTGYFSHDNIINGTYLIDSETYDFVQPPQMVTEWPESARDISAAKTTTYSGVPILELLPAYLDGSVDSVDSRHHWILPTIMPHIICYILPVGYLARGRTDISSVRYTDFTQVLLDGSRMLLDYDFVEAPGLAMAAFINQSLADDDPLVLSNSWGQPSVSNDSIYSIFTTVPVTYLKASNISDPLMRAALQHVDLAALQHEGYRRSVDFEYAGAAAVVTAYAYTTAQGLVVPLVVASSHAAITTPYLFLMRIFDGILVAVIVLLTGVSFNSARCLISQPLRRITALMLASMSAGRRALFYTTTSNTLLQLTEVHALIKAHNAAMQQLREIDAFVPDELRAEGRAQRAYSSVSNIASSMGISNGRKVTKFGSRCLDTHLSTAVFVTIRAPAALSSSSAVLPRTPSPPPILAEQGEQKPLRGQRLVSVVKHAAQAANTANSGPFPTPAALTAFITAVHELCHTHHGTLHRLCPDACVLHFNSAVRAHLPRGPGDASAAAAPAAAPPAPAARHGVPAAQSAPQPRPPRATRQEEMRLRAAQDARNAAAFALDLVNWTAAQSGSGENAQRDGTAAMPDVRALLDTSMFTCGQYRPAGSEQTLQVALGRDVQRDLGRVPQRIGVRVAMTEETATLLRAEDDSGSRGRGNMDAGVRQIPVDVLRTGRAGLDGDVVVLYEALPGRVAGDAAWQLYARCCCGGFEHMLRGDYAGALAAYRGVAEIADLEPGLLPAAMRREAAASAVTGGAVSVQVARLMRECERRVRLRITEPLCTAISSLLGVDQVLSKWALEDVPEGSHPDCAQEALVEAEKSIADGRLRRSSRRSAQSFGELAKYPEVRHRCVVHFQERQVTLRCVLPSAPRWIRDHIGLCWHLSRSHGTDEATPVWSGMQMALGSAGFIASVSFSTFRDLHPVVAKAIRDAPPGPMSDALRSATPVCGPSPEQEAFMKATLLKHQHLRHPNIVSLIGYSHSLEGGVVLIWEFSPGGTLRELLNRYGRLPAITTIRFGLHALSALSFLHENNIAHGNLNLDTVMVDSDGSCRLVGLYTHERLPFALPQTHYISPLMATGALPTPACDVFCYGLGALEGLTLQPCWRWATKEDGEPYGAASELLDLMKNGGHAFCDAVVQGRVVANAEAFDTPLFAEKYSELARSTLRSCVSHTPSDRPTAVEVRNIVKILLSEGGLACEEDEV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.....-..920.......930....---...940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060...-...1070......1080......1090......1100......1110......1120......1130......1140--.......1150......1160.-------------......1170......1180......1190......1200---..-....1210.---...----...-----------.------------1220......1230--......1240......1250...-...1260-----......1270......1280......1290......1300......1310......1320......1330......1340......1350......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRL
Q
S
SRLSSGAT
A
P
K
Q
L
H
RDVPSPGR
P
V
K
T
R
M
R
C
R
F
A
V
L
K
Y
F
L
L
RVD
V
S
V
S
I
V
Y
L
L
V
L
L
C
V
A
V
P
I
V
V
V
S
Q
V
Y
L
T
R
M
L
V
A
S
W
RTVHN
T
R
V
Y
Y
I
T
E
R
I
S
I
S
T
I
S
V
R
D
IAN
G
F
M
A
L
NIPGGGSYG
D
H
D
L
M
E
N
L
C
S
S
LD
N
Y
D
K
L
T
R
F
R
A
L
S
L
V
S
LE
T
E
S
A
I
S
C
IHGIP
T
M
D
S
M
R
T
L
T
GYFSHDNIIN
G
T
Y
L
IDSETYDFVQP
P
Q
M
V
T
EWPESARDISAAKTTTYSG
V
P
I
L
E
L
L
P
A
Y
LDGSVDSVDSRH
H
W
I
L
P
T
I
M
P
H
I
I
C
Y
I
L
P
V
G
Y
LARGRTDISSVR
Y
T
D
F
T
Q
V
L
LDG
S
R
M
L
L
D
Y
DFVEAP
G
L
A
M
A
A
F
I
N
Q
SLADDD
P
L
V
LSNSWGQPSVSND
S
I
Y
S
I
F
TTV
P
V
T
Y
L
KASNIS
D
P
L
M
R
A
A
L
Q
H
V
D
L
A
A
L
Q
HEGYRRSVDFEYAG
A
A
A
V
V
T
A
Y
A
YTTAQ
G
L
V
V
P
L
V
VASSHAA
I
T
T
P
Y
L
F
L
M
R
I
F
D
G
I
L
V
A
V
I
V
L
L
TGVSFN
S
A
R
C
L
I
S
Q
P
L
R
R
I
T
A
L
M
L
A
S
MSAG
R
R
A
L
F
Y
TTTSN
T
L
L
Q
L
T
E
V
H
A
L
I
K
A
H
N
A
A
M
Q
Q
L
R
E
I
D
AFV
P
D
E
L
R
AEG
R
A
Q
R
A
Y
S
S
V
S
N
I
A
S
SMGISNGR
K
V
T
K
F
G
S
R
C
L
D
T
HLS
T
A
V
F
V
T
I
RAPAALSSSSAVLPRTPSPPPILAEQGEQKPL
R
G
Q
R
L
V
S
V
V
K
H
A
A
Q
AANTANSGPFP
T
P
A
A
L
T
A
F
I
T
A
V
H
E
L
C
H
THH
G
T
L
H
R
LC
P
D
A
C
V
L
H
F
N
S
A
V
R
A
HLPRGPGDASAAAAPAAAPPAPAARHGVPAAQSAPQPRPPRA
T
R
Q
E
E
M
R
L
R
A
A
QDARN
A
A
A
F
A
L
D
L
V
N
W
TAAQSGSGENAQRDGTAA
M
P
D
V
R
A
L
L
D
T
S
M
FTCGQYRPAGSE
Q
T
L
Q
V
A
LG
R
D
V
Q
R
D
L
G
R
V
P
Q
R
I
G
V
R
V
A
MTEE
T
A
T
L
L
R
AEDDSGSRGRGNMDAGVRQI
P
V
D
V
L
RTGRAGLDG
D
V
V
V
L
Y
EALPGRVA
G
D
A
A
W
Q
L
Y
A
R
C
C
CG
G
F
E
H
M
L
RGDY
A
G
A
L
A
A
Y
R
G
V
A
E
I
ADLEP
G
L
L
P
A
A
M
R
R
E
A
A
A
SAVTG
G
A
V
S
V
Q
-
V
A
R
L
M
R
E
C
E
R
R
V
R
L
R
IT
E
P
---
L
C
T
A
I
S
S
L
L
G
V
D
Q
V
L
S
K
W
ALEDVPEGSH
P
D
C
A
Q
E
A
L
V
E
A
E
K
S
IAD
G
R
L
R
R
S
S
R
R
S
A
Q
S
F
G
E
L
AK
Y
P
E
V
R
H
R
C
V
V
H
F
Q
ER
Q
V
T
L
R
C
VLPSA
P
R
W
I
R
D
H
I
G
L
C
W
HLSRSHGTDEATPVWS
G
M
Q
M
A
LGSAG
F
I
-
A
S
V
S
F
S
T
F
R
D
L
H
P
V
V
A
K
A
I
RDAPPG
P
M
S
D
A
L
R
SATPVCGPSP
E
Q
E
A
F
M
K
A
T
L
L
K
H
QHLRHPN
I
V
S
L
IGYSHSLEG
G
---
V
V
L
I
W
EFSPG
G
T
L
R
E
L
L
N
RY-G-------------RL
P
A
I
T
T
I
R
F
G
L
H
A
L
S
A
L
S
F
L
H
ENNIAHGNL
N
L
D
T
V
M
VDS---DG-
S
C
R
L
V
--
G
L
---
Y
TH----ERL-----------P------------FALPQTHYI
S
P
L
M
A--TGALPT
P
A
C
D
V
F
C
Y
G
L
G
ALE
G
L
T-LQPCWRW-----ATKEDGEPYG
A
A
S
E
L
L
D
L
M
KNG
G
H
A
F
C
D
A
V
VQG
R
V
V
ANAEAFDT
P
L
F
A
E
K
Y
S
E
L
A
R
S
T
L
R
S
C
V
SHTPSDRP
T
A
V
E
V
R
N
I
V
K
I
L
L
SEGGLACEEDEV
44
Fugue
80.62
15%
0
- C1 -
-
4BTF
2
MLKL_MOUSE
A:
[7-460]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
L
G
Q
I
I
K
L
G
Q
L
I
Y
E
Q
C
E
K
M
K
Y
C
R
K
Q
C
Q
R
L
G
N
R
V
H
G
L
L
Q
P
L
Q
R
L
Q
A
Q
G
KKN
L
P
D
D
I
T
A
A
L
G
R
F
D
E
V
L
K
E
A
N
Q
Q
I
E
K
F
I
L
F
H
E
V
N
E
K
L
R
D
V
W
E
E
L
L
L
L
L
Q
V
P
A
S
W
Q
Q
E
D
R
Q
D
A
E
E
D
G
N
E
N
M
K
V
I
L
M
Q
L
Q
I
S
V
E
E
I
N
K
T
L
K
Q
C
S
I
P
Q
D
L
Q
I
---
K
E
I
P
K
E
H
L
G
P
P
W
T
K
L
K
T
S
K
M
S
T
I
Y
R
G
E
Y
H
R
S
P
V
T
I
K
V
F
N
N
-------------------------
P
Q
A
E
S
V
G
I
V
R
F
T
F
N
D
E
I
K
T
M
K
K
F
D
S
P
N
I
L
R
I
F
G
I
C
I
D
Q
T
V
K
P
P
E
F
S
I
V
M
E
Y
C
E
L
G
T
L
R
E
L
L
D
R
E
-
K
-------------
D
L
T
M
S
V
R
S
L
L
V
L
R
A
A
R
G
L
Y
R
L
H
H
S
E
T
L
H
R
N
I
S
S
S
S
F
L
V
A
G
---
G
Y
-
Q
V
K
L
A
--
G
F
EL
S
K
T
Q
----
N
S
I
-----------
S
------------
R
T
A
S
S
T
I
Y
V
S
P
E
R
L
K
N
P
F
C
L
Y
D
I
K
A
E
I
Y
S
F
G
I
V
L
W
E
I
A
T
-
G
K
I
P
F
E
G
-----
C
D
---------
S
K
K
I
R
E
L
V
A
E
D
K
K
-------------------
Q
E
P
V
G
Q
D
C
P
E
L
L
R
E
I
I
N
E
C
R
A
H
E
P
S
Q
R
P
S
V
D
G
I
L
E
R
L
S
A
--------------
45
Fugue
79.73
18%
-63
- C1 -
-
1VR2
-
VGFR2_HUMAN
A:
[820-1168]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
-
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
-
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
---
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
NEFVPYKD-----
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
---
K
N
-
V
V
K
I
C
--
D
F
D-------------------------------------
A
R
L
P
L
K
W
M
A
P
E
T
I
--
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
A
S
P
Y
P
-----
G
V
K
I
D
-------
E
E
F
C
R
R
L
K
E
G
T
R
-----------------
M
R
A
P
---
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------
23
HHSearch
79.50
23%
-73
- C1 -
-
4IDV
1
M3K14_HUMAN
A:
[116-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
M
A
C
A
G
L
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
-
G
P
W
---
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
-
G
-------------
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
---
D
G
S
H
A
A
L
C
--
D
F
---
G
H
A
----
V
C
L
-----------
Q
PDGLGKSLLTGD
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
--
L
G
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
Q
-----
F
F
R
G
P
---------
L
C
L
-----------
K
I
A
S
E
P
P
-------
P
V
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
-------
40
HHSearch
77.06
19%
-51
- C1 -
-
2Y6O
1
A:
[8-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
A
S
C
I
K
I
E
K
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
K
V
P
G
K
R
E
I
C
--------------
V
A
I
K
T
L
K
A
G
Y
T
-----------------
D
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
-
K
P
---
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
N
D
G
-------------
R
F
T
V
I
Q
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
---
N
L
-
V
C
K
V
S
--
D
F
----------------------------------------
I
P
I
R
W
T
A
P
E
A
I
--
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
-----
M
S
N
Q
---------
D
V
I
K
A
I
-----------
E
E
G
Y
---------
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
I
R
N
P
N
S
-------
12
PsiBlast_PDB
76.99
24%
0
- C- -
-
3V5P
1
?
A:
[69-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
-
K
G
Y
---
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
-------------
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
A
-
N
I
R
I
I
DF
G
L
---
S
T
H
F
EAS
K
K
M
-----------
K
------------
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
Y
D
-
E
K
C
D
V
--
W
S
T
G
V
I
L
Y
I
L
-
L
S
G
C
--------------
P
P
F
N
G
A
N
E
-
Y
D
I
L
K
-------------
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
-----------------------
9
PsiBlast_PDB
76.99
24%
0
- C- -
-
3UPX
1
?
A:
[69-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
-
K
G
Y
---
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
-------------
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
A
-
N
I
R
I
I
DF
G
L
---
S
T
H
FEAS
K
K
M
-----------
K
------------
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
Y
D
-
E
K
C
D
V
--
W
S
T
G
V
I
L
Y
I
L
-
L
S
G
C
--------------
P
P
F
N
G
A
N
E
-
Y
D
I
L
K
-------------
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
-----------------------
43
Fugue
76.60
18%
-65
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
------------
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
-
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
-----------------------
L
E
V
F
R
A
E
E
L
M
A
C
A
G
L
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
-
G
P
W
---
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
-
G
-------------
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
---
D
G
-
S
H
A
A
L
--
C
D
---
F
G
H
----
A
V
C
-----------
L
------------
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
--
L
G
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
Q
FFRGP
L
C
L
K
I
A
S
E
P
P
P
V
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
------------------------
22
HHSearch
75.78
23%
-65
- C1 -
-
4G3F
1
A:
[99-321]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
V
A
C
A
G
L
S
S
P
R
I
V
P
L
Y
G
A
V
R
E
-
G
P
W
---
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
-
G
-------------
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
---
D
G
S
R
A
A
L
C
--
D
F
---
G
H
A
----
L
C
L
------------D-----------
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
--
M
G
K
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
Q
-----
Y
F
R
G
P
---------
L
C
L
-----------
K
I
A
S
E
P
P
-------
P
I
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
V
G
K
A
L
Q
E
V
G
G
L
------
30
HHSearch
75.72
17%
-61
- C1 -
-
2QOC
2
A:
[11-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
K
K
E
I
S
--------------
V
A
I
K
T
L
K
V
G
Y
T
-----------------
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
-
S
K
P
---
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
-
D
A------------
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
---
N
L
-
V
C
K
V
S
--
D
F
---
G
L
S
----
R
V
L
-----------
E
D-------------
K
I
P
I
R
W
T
S
P
E
A
I
--
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
-----
M
S
N
Q
---------
D
V
I
K
-----------
A
V
D
E
G
Y
---------
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
---------
24
HHSearch
74.35
16%
-69
- C1 -
-
4KNB
3
MET_HUMAN
A:
[9-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
-----
K
I
H
--------------
C
A
V
K
S
L
---
T
D
-----------------
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
---
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
-
T
H
------------
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
---
K
F
-
T
V
K
V
A
--
D
F
---
G
L
A
----
R
D
M
YDKEYYSVHNK
T
------------
G
A
K
L
P
V
K
W
M
A
L
E
S
L
--
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
-
R
G
A
P
P
Y
P
-----
D
V
N
T
F
--------
D
I
T
V
-----------
Y
L
L
Q
G
R
---------
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
----------
16
PsiBlast_PDB
74.27
24%
-52
- C1 -
-
4ONA
1
?
A:
[69-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
-
K
G
Y
---
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
-------------
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
A
-
N
I
R
I
I
DF
G
L
---
S
T
H
F
EAS
K
K
M
-----------
K
------------
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
Y
D
-
E
K
C
D
V
--
W
S
T
G
V
I
L
Y
I
L
-
L
S
G
C
--------------
P
P
F
N
G
A
N
E
-
Y
D
I
L
K
-------------
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
-----------------------
13
PsiBlast_PDB
74.07
24%
-51
- C1 -
-
3V5T
1
?
A:
[69-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
-
K
G
Y
---
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
-------------
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
A
-
N
I
R
I
I
DF
G
L
---
S
T
H
F
EAS
K
K
M
-----------
K
------------
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
Y
D
-
E
K
C
D
V
--
W
S
T
G
V
I
L
Y
I
L
-
L
S
G
C
--------------
P
P
F
N
G
A
N
E
-
Y
D
I
L
K
-------------
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
-----------------------
26
HHSearch
73.72
15%
-72
- C1 -
-
4AT5
2
A:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
-----------------
K
I
L
V
A
V
K
T
L
K
D
A
S
D
------------------
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
-
G
D
P
---
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
-
G
P
D
A
V
L
M
AE
G
N
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
---
N
L
-
L
V
K
I
G
--
D
F
---
G
M
S
----
R
D
V
YSTDYYRVG--
G
------------
H
T
M
L
P
I
R
W
M
P
P
E
S
I
--
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-----
L
S
N
N
E
---------
V
I
-----------
E
C
I
T
Q
G
R
V
---------
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
-------
2
PsiBlast_PDB
73.71
24%
-49
- C1 -
-
3I79
1
?
A:
[69-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
-
K
G
Y
---
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
-------------
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
A
-
N
I
R
I
I
DF
G
L
---
S
T
H
F
EAS
K
K
M
-----------
K
------------
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
Y
D
-
E
K
C
D
V
--
W
S
T
G
V
I
L
Y
I
L
-
L
S
G
C
--------------
P
P
F
N
G
A
N
E
-
Y
D
I
L
K
-------------
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
-----------------------
3
PsiBlast_PDB
73.66
24%
-43
- C1 -
-
3I7B
4
?
A:
[69-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
-
K
G
Y
---
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
-------------
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
A
-
N
I
R
I
I
DF
G
L
---
S
T
H
F
E
A
S
K
K
M
-----------
K
------------
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
Y
D
-
E
K
C
D
V
--
W
S
T
G
V
I
L
Y
I
L
-
L
S
G
C
--------------
P
P
F
N
G
A
N
E
-
Y
D
I
L
K
-------------
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
-----------------------
8
PsiBlast_PDB
73.47
24%
-51
- C1 -
-
3T3V
2
?
A:
[69-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
-
K
G
Y
---
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
-------------
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
A
-
N
I
R
I
I
DF
G
L
---
S
T
H
F
EAS
K
K
M
-----------
K
------------
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
Y
D
-
E
K
C
D
V
--
W
S
T
G
V
I
L
Y
I
L
-
L
S
G
C
--------------
P
P
F
N
G
A
N
E
-
Y
D
I
L
K
-------------
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
-----------------------
18
PsiBlast_PDB
73.36
24%
-49
- C1 -
-
4WG3
1
?
A:
[69-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
-
K
G
Y
---
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
-------------
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
A
-
N
I
R
I
I
DF
G
L
---
S
T
H
F
EAS
K
K
M
-----------
K
------------
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
Y
D
-
E
K
C
D
V
--
W
S
T
G
V
I
L
Y
I
L
-
L
S
G
C
--------------
P
P
F
N
G
A
N
E
-
Y
D
I
L
K
-------------
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
-----------------------
5
PsiBlast_PDB
73.30
24%
-50
- C1 -
-
3SX9
1
?
A:
[69-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
-
K
G
Y
---
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
-------------
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
A
-
N
I
R
I
I
DF
G
L
---
S
T
H
FEAS
K
K
M
-----------
K
------------
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
Y
D
-
E
K
C
D
V
--
W
S
T
G
V
I
L
Y
I
L
-
L
S
G
C
--------------
P
P
F
N
G
A
N
E
-
Y
D
I
L
K
-------------
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
-----------------------
4
PsiBlast_PDB
73.30
24%
-44
- C1 -
-
3N51
3
?
A:
[69-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
-
K
G
Y
---
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
-------------
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
A
-
N
I
R
I
I
DF
G
L
---
S
T
H
F
E
A
S
K
K
M
-----------
K
------------
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
Y
D
-
E
K
C
D
V
--
W
S
T
G
V
I
L
Y
I
L
-
L
S
G
C
--------------
P
P
F
N
G
A
N
E
-
Y
D
I
L
K
-------------
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
-----------------------
7
PsiBlast_PDB
73.26
24%
-46
- C1 -
-
3T3U
5
?
A:
[69-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
-
K
G
Y
---
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
-------------
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
A
-
N
I
R
I
I
DF
G
L
---
S
T
H
FEAS
K
K
M
-----------
K
------------
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
Y
D
-
E
K
C
D
V
--
W
S
T
G
V
I
L
Y
I
L
-
L
S
G
C
--------------
P
P
F
N
G
A
N
E
-
Y
D
I
L
K
-------------
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
-----------------------