@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_32_0820: (2018-03-12 )
MDSTLAKLPATRWDRLMAVLEENEPERAIDAPNILERAKKLNLSDLELFYLLLMRYQDKQPKILMDVVSLYAMMSTWMEWIVQVQRCLDAKKRKMDAGSPSHTATGVPVLMPTSSDFADSGRTFLSCPSSNCTNTPISSNPAYSSENYGNDFGSRPDSATHAARNPVSSTVRGFHDKSGRRSHSTSFHWCFDLGPDWKWDGSLDFLRNGRVLSCLVEEALDRCGKLEVLPDDHRVHPGTPNPITHEILYPSLADIDRVFKGAAEDGATDVVSASRSFSKLNYLSTLDFSRGLQLSRGDKAQPSKALKLIEEQGKNLAAAEQWVRKLNSMCERFLGWEKSAHENRAFFDLCNPDNLVRPLNSDDARLLYRMHWLAVALYRAVKDASIIPAPPRMSFIVCHDDLGGLPDTSAEDDEIGLLVATKCSCLPLKARLSVTMKDFNTMQLLHPDMKHGPRVLPCTIVKGEVFAYFEERHTFVPVWSVFQYHLQHFDGLVWCFEMSRQEREQERQVLGTNFSATRPDLGASDDFAFNGSSAAFDLTVHSSTVRHDRQRRPPESPSNTQWMRGSITPKPFDLPTDCKASVTLLPQRFPHQPAAQSGTGVEMGVSVSKVRLNRIAIPSPRPSSACPSPSSSPATTSRAADPFAQLSATPAAGTGITNNANAFSSTTCGVSTAVVTSASSSGIDAVLNAIKSPISDLSLSMTASRQATAVCTTGEQETPSTHIAYLLPPKRSSEALDESTENTELLSREVTVCMEAKTKEVVECDRIVGAAASDAAVLKPSCTISCSPCSQVMVTQEAHYHGGAEAPEEDDDVISDATMTVVCSESHTIIRNFTAAVVQESEQSGISILSHHFRVSSGPIGKGAFGAVYRALNLDTGRIVAVKQSRYSYDDKTADLNWREFQMWSMLPPHANVITFYGASREVDTNQLLLVMEYASGGSIVQLYRYFRPIPEPLFYDHAVGIARGLKHLHDHNVIHGDVKPENVLTRSDGSVAISDFGCSSFSLVSSDNGSPLLRSSKRESGSLQLFGTAAYMAPEVILNEPHLKSDVWAYACTLVQLWLGKSPWSYGERRFSALDSIPLMFYIANEEVVPFTTEQLERSPRWLQCIARRAFERDVERRCTMAEIISILADYSKVYRP
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.-..-....770......-.780.......--790-----.......800.......810.......820...-.--...830.......840.......850..--.....860.......870..--.....880...--....890-----......-...900.......910.......920.......930.......940-..-...-------------.----.----950--.......960.-......970-.......980...--...---.---990--.-........1000......1010......1020......1030.....-.-------1040.-.-.....1050......1060.......1070......1080-.....-------....1090......1100----------------.......1110......1120..-----.--.---..1130..---------------...--------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDS
T
L
A
KLP
A
T
R
W
D
R
L
M
A
V
L
EENEPERAIDA
P
N
I
L
E
R
A
K
KLN
L
S
D
L
E
L
F
Y
L
L
L
M
R
YQDKQ
P
K
I
L
M
D
V
V
S
L
Y
A
M
M
S
T
W
M
E
W
I
V
Q
V
Q
R
C
L
D
A
K
K
RKMDAGSPSHTATG
V
P
V
L
MPTSSDFADSG
R
T
F
L
SCPSSNCTNTPISSNPAYSSENYGNDFGSRPDSATHAARN
P
V
S
S
T
V
R
G
FHDKSGRRSHST
S
F
H
W
C
F
DLGPDWKWDGS
L
D
F
L
RNGR
V
L
S
C
L
V
E
E
A
L
D
RCGKLEVLPDDHRVHPGTPNP
I
T
H
E
I
LY
P
S
L
A
D
I
D
R
V
F
KGAAEDGA
T
D
V
V
S
A
SRSFSKL
N
Y
L
S
TLDFSRGLQLSRGDKAQ
P
S
K
A
L
K
L
I
E
EQGK
N
L
A
A
A
E
Q
W
V
R
K
L
N
S
M
C
E
R
F
LGWEKSAHENR
A
F
F
DLC
N
P
D
N
LVRPLNSD
D
A
R
L
L
Y
R
M
H
W
L
A
V
A
L
Y
R
A
VKDASIIPAPP
R
M
S
F
I
V
C
HDDLGGLPDTSAEDD
E
I
G
L
L
V
ATKCSC
L
P
L
K
A
R
L
S
V
T
MKDF
N
T
M
Q
LLHPDMKHG
P
R
V
L
P
C
T
IVKGE
V
F
A
Y
F
E
ER
H
T
F
V
P
V
W
S
V
F
Q
Y
H
L
Q
HF
D
G
L
V
W
C
F
E
M
S
R
Q
E
R
E
Q
E
R
Q
V
LGTNFSATRPDLGASDD
F
A
FNGSS
A
A
F
D
L
T
VHS
S
T
VR
H
D
R
QRRPPESPSNT
Q
W
M
RGSITPKPFDLPTDCKA
S
V
T
LLPQRFPHQPAAQSGTG
V
E
MG
V
S
V
S
K
V
R
L
N
R
I
AIPSPRPSSACPSPSSSPATTSRAADP
F
A
QLSATPAAGTGITNNANAFSSTTCG
V
S
T
A
V
V
TSASSS
G
I
D
A
V
L
N
A
I
KS
P
I
S
D
L
S
L
S
M
TASR
Q
A
T
A
V
C
TTGEQETPS
T
H
I
A
Y
L
LPPKRS
S
E
ALDESTE
N
T
E
L
L
S
R
E
V
T
V
C
MEAK
T
K
E
V
V
E
-
C
D
-
R
I
VGAAASD
A
A
V
L-KP
S
C
T
I
SCSPC--S
Q
V
-----
M
V
T
QEAHYHGGAEAPEEDDDVISD
A
T
M
T
V
V
CSE-S--
H
T
I
I
R
N
F
T
A
A
V
V
Q
ESEQS
G
I
S
I
L
S
H
H
FR--VSSGPIGK
G
A
F
G
A
V
Y
R
A
LNL--DT
G
R
I
V
A
V
KQS--RYSYD-------DKTADL-N
W
R
E
F
Q
M
W
SMLPPHA
N
V
I
T
F
YGASREVDTN
Q
L
L
L
V
M
E
YASG
G
S
I
V
Q
-
L
Y
-
R
Y
F
-------------R----P----IPE--
P
L
F
Y
D
H
A
V
G
I
A
-
R
G
L
K
H
L
HDH-NVIHGDVKPEN
V
L
--TRS---D---G----
S
-
V
A
I
S
DFGCS
S
F
S
L
V
SSDNGSP
L
L
RSSKRESG
S
L
Q
L
F
G
T
A
A
YMA
P
E
V
I-L-------NEP-H-L-KS
D
V
W
A
Y
A
C
T
L
V
Q
L
W
L-GKSPWS
Y
G
E
R
R
F
S
A
LDSI
P
L
----
M
F
Y
IA-------NEEVVPF
T
T
E
Q
L
ERS
P
R
-----------------
W
L
Q
C
I
A
R
R
A
F
E
R
D
V
E
RRC
T
M
A
E
I
-----
I
--
S
---
I
L
A
D
Y
S
K
V---------------YRP--------------------------------------------------------
44
Fugue
78.91
23%
-44
- C1 -
-
1KOB
1
?
A:
[23-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
-
Y
--
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
--
I
L
E
-
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
--
A
T
G
R
V
F
V
A
K
F
I
--
N
T
P
Y
P
-------
L
D
K
Y
T
V
-
K
-
N
E
I
S
I
M
N
Q
L
H
-
H
P
K
L
I
N
L
H
D
A
F
E
--
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
-
A
E
D
-------------
Y
----
K
----
M
S
E
--
A
E
V
I
N
Y
M
R
Q
A
C
-
E
G
L
K
H
M
H
E
H
-
S
I
V
H
L
D
I
K
P
E
N
I
M
CE
T
K
K
---
A
---
S
----
S
-
V
K
I
I
D
F
G
--------------
L
A
T
K
L
N
P
D
E
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
-
D
-------
R
E
P
-
V
G
F
-
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
-
G
L
S
P
F
-
A
G
E
D
D
L
E
T
L
Q
N
V
K
R
----
C
D
W
--------------
E
F
D
E
D
A
F
S
S
V
S
P
-----------------
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
-----
L
--
E
HPW
L
K
G
D
H
S
N
L
---------------
T
S
R
IPSSRY
N
K
I
R
Q
K
I
K
E
K
Y
ADWPAPQPAIGRIANFSSLRKHRPQEYQ
I
Y
D
S
Y
F
DRKEA
45
Fugue
73.87
21%
-46
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
K
Y
M
--
I
A
E
-
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
--
S
S
K
K
T
Y
M
A
K
F
V
--
K
V
K
---------
G
T
D
Q
V
L
-
V
K
K
E
I
S
I
L
N
I
A
R
-
H
R
N
I
L
H
L
H
E
S
F
E
S
--
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
-
R
I
N
T
S
A
-------------
F
----
E
----
L
N
E
--
R
E
I
V
S
Y
V
H
Q
V
C
-
E
A
L
Q
F
L
H
S
H
-
N
I
G
H
F
D
I
R
P
E
N
I
I
YQ
T
R
R
---
S
---
S
----
T
-
I
K
I
I
E
F
G
--------------
Q
A
R
Q
L
K
P
G
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
-
Q
-------
H
D
V
V
S
-
T
-
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
-
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
----
A
E
Y
--------------
T
F
D
E
E
A
F
K
E
I
S
I
-----------------
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
-----
L
Q
H
P
---
W
L
K
Q
K
I
E
R
---------------
V
S
T
KVIRT
L
K
H
R
R
Y
Y
H
T
L
IKKDLNMVVSAARISCGGAIRSQKG
V
S
V
A
K
V
K
V
A
SI-----
43
Fugue
72.71
26%
-44
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
--
Y
L
V
-----
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
-
P
--
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
--
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
--
Q
T
G
F
Q
C
A
V
K
K
V
--
R
L
E
V
F
-------
R
A
-------
E
E
L
M
A
C
A
G
L
T
-
S
P
R
I
V
P
L
Y
G
A
V
R
E
--
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
-
L
V
-
K
E
Q
-------------
G
----
C
----
L
P
E
--
D
R
A
L
Y
Y
L
G
Q
A
L
-
E
G
L
E
Y
L
H
S
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
--
L
S
S
---
D
---
G
----
S
H
A
A
L
C
D
F
G
H
A
---------------------
V
C
L
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
-
L
-------
G
R
S
-
C
D
A
-
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
-------
Q
F
F
R
G
P
L
----
C
L
K
I
A
-------
S
E
P
--
P
P
V
R
E
I
P
P
S
C
A
P
-----------------
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
-----
G
--
G
---
K
V
N
R
A
L
Q
Q
V
GGLKSPWR
G
E
Y
K
E
P
R
H
P
--------------------------------------------------------
22
HHSearch
72.51
29%
-65
- C1 -
-
4G3F
1
A:
[63-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
--
Q
T
G
F
Q
C
A
V
K
K
V
--
R
L
E
V
-------------
F
-
R
V
E
E
L
V
A
C
A
G
L
-
S
S
P
R
I
V
P
L
Y
G
A
V
R
E
--
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
-
L
I
-
K
Q
M
-------------
G
----
C
----
L
P
E
--
D
R
A
L
Y
Y
L
G
Q
A
L
-
E
G
L
E
Y
L
H
T
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
--
L
S
S
---
D
---
G
S---
R
-
A
A
L
C
D
F
G
H
A
L
C
L
--------------------
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
-
M
G------
K
P
C
-
D
-
A
-
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
Q
Y
-------
F
R
G
P
L
----
C
L
K
I
A
-------
S
E
-
P
P
P
-
I
R
E
I
P
P
S
C
A
P
-----------------
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
-----
R
--
R
---
K
V
G
K
A
L
Q
---------------------------------------------------------------------------
29
HHSearch
67.81
20%
-59
- C1 -
-
3CBL
3
A:
[113-375]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
D
L
V
--
L
-
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
--
A
D
N
T
L
V
A
V
K
S
C
--
R
E
T
L
P
-------
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
--
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
-
F
L
-
R
T
E
G------------
A
----
R
----
L
R
V
--
K
T
L
L
Q
M
V
G
D
A
A
-
A
G
M
E
Y
L
E
S
K
-
C
C
I
H
R
D
L
A
A
R
N
C
L
--
V
T
E
---
K
---
N
----
V
-
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
-----------
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
-
N
Y------
G
R
Y
-
S
-
S
-
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
-------
S
N
Q
Q
T
----
R
E
F
V
E
-------
K
G
G
R
L
P
-
C
---
P
E
L
C
P
D
-----------------
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
-----
Y
--
Q
---
E
L
Q
S
I
R
K
R
--------------------------------------------------------------------------
27
HHSearch
67.49
20%
-58
- C1 -
-
3BKB
7
A:
[114-375]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
L
V
--
L
-
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
--
A
D
N
T
L
V
A
V
K
S
C
--
R
E
T
L
P
-------
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
--
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
-
F
L
-
R
T
E
G------------
A
----
R
----
L
R
V
--
K
T
L
L
Q
M
V
G
D
A
A
-
A
G
M
E
Y
L
E
S
K
-
C
C
I
H
R
D
L
A
A
R
N
C
L
--
V
T
E
---
K
---
N
----
V
-
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
-----------
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
-
N
Y------
G
R
Y
-
S
-
S
-
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
-------
S
N
Q
Q
T
----
R
E
F
V
E
-------
K
G
G
R
L
P
-
C
---
P
E
L
C
P
D
-----------------
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
-----
Y
--
Q
---
E
L
Q
S
I
R
K
R
--------------------------------------------------------------------------
24
HHSearch
65.66
29%
-57
- C1 -
-
4IDV
1
M3K14_HUMAN
A:
[79-331]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
--
Q
T
G
F
Q
C
A
V
K
K
V
--
R
L
E
V
-------------
F
-
R
A
E
E
L
M
A
C
A
G
L
-
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
--
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
-
L
V
-
K
E
Q
-------------
G
----
C
----
L
P
E
--
D
R
A
L
Y
Y
L
G
Q
A
L
-
E
G
L
E
Y
L
H
S
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
--
L
S
S
---
D
---
G
S---
H
-
A
A
L
C
D
F
G
H
A
V
C
L
Q
P
D
G
---
L
G
-----
K
S
L
L
T
G
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
-
L
G------
R
S
C
-
D
-
A
-
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
Q
F
-------
F
R
G
P
L
----
C
L
K
I
A
-------
S
E
-
P
P
P
-
V
R
E
I
P
P
S
C
A
P
-----------------
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
-----
G
--
G
---
K
V
N
R
A
L
----------------------------------------------------------------------------
48
Fugue
64.72
19%
-24
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-
E
P
Q
A
Q
L
F
C
S
F
L
--
D
A
E
-----
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
---------
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
P
M
G
E
D
W
F
L
--
D
F
R
-
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
--
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
-------
R
K
G
Y
Q
G
-
A
M
V
E
K
K
I
L
A
K
V
H
S
R
F
I
V
S
L
A
Y
A
F
E
---
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
-
H
I
-
Y
N
V
-------------
D
----
E
D
N
P
G
F
Q
E
--
P
R
A
I
F
Y
T
A
Q
I
V
-
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
--
L
D
D
---
D
---
G
----
N
-
V
R
I
S
D
L
G
----
L
A
V
E
L
K
A
G
Q
T
K
T
K
G
Y
A
---------
G
T
P
G
F
M
A
P
E
L
L
-
L
-------
G
E
E
-
Y
D
F
-
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
-
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
----
V
L
E
Q
A
V
T
Y
P
DKF
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
KRLGFRDGSC
D
G
L
R
T
HP
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
-----
R
--
T
---
V
Y
A
K
N
G
A
F
---------------
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
SGTC
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
VWRP----------------
42
HHSearch
64.29
24%
-20
- C1 -
-
4AT5
2
A:
[12-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
N
I
V
--
L
-
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
NL--
K
I
L
V
A
V
K
T
L
--
K
D
A
S
D
--------
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
--
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
-
F
L
-
R
A
H
G
P
D
A
V
L
M
AE
G
N
P
P
T
----
E
----
L
T
Q
--
S
Q
M
L
H
I
A
Q
Q
I
A
-
A
G
M
V
Y
L
A
S
Q
-
H
F
V
H
R
D
L
A
T
R
N
C
L
--
V
G
E
---
N
---
L
----
L
-
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
-----------
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
-------
R
K
F
-
T
-
T
-
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
-------
S
N
N
E
V
----
I
E
C
I
T
-------
Q
G
-
R
V
L
Q
R
---
P
R
T
C
P
Q
-----------------
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-----
H
--
T
---
L
L
Q
N
L
A
K
A
--------------------------------------------------------------------------
49
Fugue
62.74
17%
-7
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
-
R
K
A
C
G
R
N
L
T
Q
N
F
L
-
S
H
T
G
P
D
L
I
P
E
V
--
P
R
Q
-----
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
-
F
--
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
V
T
K
N
T
F
--
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
--
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
-------
R
K
G
E
A
M
-
A
L
N
E
K
Q
I
L
E
K
V
N
S
R
F
V
V
S
L
A
Y
A
Y
E
---
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
-
H
I
-
Y
H
M
-------------
G
----
Q
A
G
--
F
P
E
--
A
R
A
V
F
Y
A
A
E
I
C
-
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
--
L
D
D
---
H
---
G
----
H
-
I
R
I
S
D
L
G
--------------
L
A
V
H
V
P
E
G
Q
T
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
-
K
-------
N
E
R
Y
T
-
F
-
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
-
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
----
V
K
E
V
P
E
E
Y
S
ERF
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
ERLGCRGGS--------
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E----
P
--
P
---
F
K
P
D
P
Q
A
I
---------------
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
ATGSVP
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
VFGLDGS----------------
23
HHSearch
62.15
22%
-14
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[93-359]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
K
Y
D
--
P
-
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
--
A
T
G
H
E
F
A
V
K
I
M
--
E
V
T
A
E
RLSPEQL
E
E
V
R
E
A
-
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
--
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
-
T
E
K
-------------
V
----
A
----
L
S
E
--
K
E
T
R
S
I
M
R
S
L
L
-
E
A
V
S
F
L
H
A
N
-
N
I
V
H
R
D
L
K
P
E
N
I
L
--
L
D
D
---
N
---
M
----
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
--------------
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
-
K
CSMDETH
P
G
Y
-
G
-
K
-
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
H
R
-------
R
Q
I
L
M
----
L
R
M
I
M
-------
E
G
-
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
-----------------
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
-----
L
--
Q
-------------------------------------------------------------------------------------
26
HHSearch
61.14
19%
-8
- C1 -
-
3I6U
-
CHK2_HUMAN
A:
[99-482]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
D
G
F
A
N
L
E
C
V
N
D
N
-
Y
W
F
G
R
D
K
-
S
C
E
Y
C
-
F
D
-
E
P
L
L
K
R
T
D
K
Y
R
T
Y
S
K
K
H
F
R
I
F
R
E
V
G
PK
N
S
Y
I
A
Y
I
E
D
H
S
G
N
G
T
F
V
N
T
E
L
V
G
K
G
K
R
R
P
L
N
N
N
S
E
I
A
L
S
L
S
-
R
NK
V
F
V
F
F
D
L
T
V
----
D
D
Q
S
V
Y
P
K
A
L
R
D
E
Y
I
--
M
-
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
--
K
T
C
K
K
V
A
I
R
I
I
--
S
K
R
K
F
AIG--------
L
N
-
V
E
T
E
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
A
---
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
-
V
G
N
-------------
K
----
R
----
L
K
E
--
A
T
C
K
L
Y
F
Y
Q
M
L
-
L
A
V
Q
Y
L
H
E
N
-
G
I
I
H
R
D
L
K
P
E
N
V
L
--
L
S
S
QEE
D
---
C
----
L
-
I
K
I
T
D
F
G
H
S
K
I
L
G
-------------------------
P
T
Y
L
A
P
E
V
L
-
V
-------
A
G
Y
-
N
-
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
-
G
Y
P
P
F
S
E
H
R
------
T
Q
V
S
L
----
K
D
Q
I
T
-------
S
G
-
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
-----------------
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
-----
L
--
R
-------------------------------------------------------------------------------------
28
HHSearch
60.99
22%
-11
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[93-359]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
K
Y
D
--
P
-
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
--
A
T
G
H
E
F
A
V
K
I
M
--
E
V
---RLSPEQL
E
E
V
R
E
A
-
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
--
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
-
T
E
K
-------------
V
----
A
----
L
S
E
--
K
E
T
R
S
I
M
R
S
L
L
-
E
A
V
S
F
L
H
A
N
-
N
I
V
H
R
D
L
K
P
E
N
I
L
--
L
D
D
---
N
---
M
----
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
--------------
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
-
K
CSMDETH
P
G
Y
-
G
-
K
-
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
H
R
-------
R
Q
I
L
M
----
L
R
M
I
M
-------
E
G
-
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
-----------------
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
-----
L
--
Q
-------------------------------------------------------------------------------------
1
PsiBlast_PDB
59.15
35%
-64
- C- -
-
5CEN
-
M3K12_HUMAN
A:
[131-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
S
G
A
Q
G
A
V
F
--
L
G
R
--
F
H
G
E
E
V
A
V
K
K
V
--
R
---
D
-------
L
K
E
T
D
I
K
H
L
R
K
L
K
-------
H
P
N
I
I
T
F
K
G
V
C
T
Q
A
P
C
Y
C
I
L
--
M
E
F
C
A
Q
G
Q
L
Y
E
-
V
L
-
R
A
G
-------------
R
----
P
----
V
T
P
--
S
L
L
V
D
W
S
M
G
I
A
-
G
G
M
N
Y
L
H
L
H
-
K
I
I
H
R
D
L
K
S
P
N
M
L
--
I
T
Y
---
D
---
D
----
V
-
V
K
I
S
D
F
G
T
S
--------------
K
E
L
S
D
K
S
T
K
M
S
F
A
G
T
V
A
W
M
A
P
E
V
I
-
R
-------
N
E
P
V
S
-
E
-
K
V
D
I
W
S
F
G
V
V
L
W
E
L
L
T
-
G
E
I
P
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
58.72
25%
-54
* C1 *
-
3C0G
1
CSKP_HUMAN
B:
[22-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
--
L
-
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
--
E
T
G
Q
Q
F
A
V
K
I
V
--
D
V
A
K
F
T
S
SP---
G
L
S
T
E
D
-
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
-
E
I
-
V
K
R
-------------
A
D
A
G
F
V
----
Y
S
E
--
A
V
A
S
H
Y
M
R
Q
I
L
-
E
A
L
R
Y
C
H
D
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
--
L
A
S
---
K
ENS
A
----
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
-------------
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
-
K
R------
E
P
Y
-
G
-
K
-
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
C
L
P
F
Y
G
T
K
--------
E
R
L
----
F
E
G
I
I
-------
K
G
-
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
-----------------
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
-----
L
--
N
-------------------------------------------------------------------------------------
31
HHSearch
58.67
20%
-61
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[21-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
K
Y
M
--
I
-
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
--
S
S
K
K
T
Y
M
A
K
F
V
--
K
V
K
G
---------
T
D
Q
V
L
-
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
--
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
-
R
I
-
N
T
S
A------------
F
----
E
----
L
N
E
--
R
E
I
V
S
Y
V
H
Q
V
C
-
E
A
L
Q
F
L
H
S
H
-
N
I
G
H
F
D
I
R
P
E
N
I
I
--
Y
Q
T
RR-
S
---
S
----
T
-
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
--------------
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
-
Q
H------
D
V
V
-
S
-
T
-
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
L
A
E
-------
T
N
Q
Q
I
----
I
E
N
I
M
-------
N
A
-
E
Y
T
F
D
E
E
A
F
K
E
I
S
I
-----------------
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
-----
L
--
Q
-------------------------------------------------------------------------------------
30
HHSearch
58.41
20%
-66
- C1 -
-
4NIF
-
KS6A1_HUMAN
A:
[6-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
D
G
Y
V
--
V
-
K
E
T
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
K
--
A
T
N
M
E
Y
A
V
K
V
I
--
D
K
S
K
------------
R
D
-
P
S
E
E
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
--
G
K
H
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
-
K
I
-
L
R
Q
-------------
K
----
F
----
F
S
E
--
R
E
A
S
F
V
L
H
T
I
G
-
K
T
V
E
Y
L
H
S
Q
-
G
V
V
H
R
D
L
K
P
S
N
I
L
--
Y
V
D
---
E
---
S
GNPE
C
-
L
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
-------------
N
G
L
L
M
T
P
C
Y
---
F
V
A
P
E
V
L
-
K
R
------
Q
G
Y
-
D
-
E
-
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
-
G
Y
T
P
F
A
N
G
P
S
----
D
T
P
E
E
I
----
L
T
R
I
G
-------
S
G
-
K
F
T
L
S
G
G
N
W
N
T
V
S
E
-----------------
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
K
Q
V
-----
L
--
Q
---
H
---------------------------------------------------------------------------------
14
PsiBlast_PDB
58.10
32%
-64
- C1 -
-
4G3F
1
A:
[58-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
W
M
--
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
--
Q
T
G
F
Q
C
A
V
K
K
V
--
R
L
E
V
-------------
F
-
R
V
E
E
L
V
A
C
A
G
L
S
S
-
P
R
I
V
P
L
Y
G
A
V
R
E
--
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
-
L
I
-
K
Q
M
-------------
G
----
C
----
L
P
E
D
R
A
L
Y
Y
---
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
--
L
S
S
---
D
---
G
----
S
R
A
A
L
C
D
F
G
-
H
A
L
C
L
------------
D
-------
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
-
M
-------
G
K
P
C
D
-
A
-
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
57.91
23%
-17
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[3-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
E
Y
Q
--
L
-
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
--
P
T
G
Q
E
Y
A
A
K
I
I
--
N
T
K
K
L
S------
A
R
D
H
Q
K
-
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
-
V
A
R
-------------
E
----
Y
----
Y
S
E
--
A
D
A
S
H
C
I
Q
Q
I
L
-
E
S
V
N
H
C
H
L
N
-
G
I
V
H
R
D
L
K
P
E
N
L
L
--
L
A
S
---
K
SKG
A
----
A
-
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
-------------
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
-------
D
P
Y
-
G
-
K
-
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
D
E
-------
D
Q
H
R
L
----
Y
Q
Q
I
K
-------
A
G
-
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
-----------------
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
-----
L
--
K
-------------------------------------------------------------------------------------
51
Fugue
57.58
22%
-7
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
T
W
R
P
R
Y
F
L
L
K
N
-
D
G
-
T
F
I
G
Y
K
E
R
P
A
-----
P
L
N
N
F
S
V
A
Q
C
---
Q
L
-----
M
K
T
E
R
P
R
P
N
----------------
T
F
I
I
R
C
L
Q
W
T
--
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
--
A
T
G
R
Y
Y
A
M
K
I
L
--
K
K
V
L
Q
-------
N
S
R
H
---------------
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
----
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
-
H
L
-
S
R
E
-------------
R
----
V
----
F
S
E
--
D
R
A
R
F
Y
G
A
E
I
V
-
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
--
L
D
K
---
D
---
G
----
H
-
I
K
I
T
D
F
G
L
C
P
-----------------------------
E
Y
L
A
P
E
V
L
-
E
-------
D
N
D
-
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
-
G
R
L
P
F
-
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
EEIR
F
P
R
T
L
-------
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
QRLGGGSE
D
--------
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
SPPFK
P
--
Q
---
V
T
S
E
T
D
T
R
---------------
Y
F
---------------------------------------------------------