@TOME V2.3
(Mar 2018)
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Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
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Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_32_1520: (2018-03-12 )
MEAVIDDEGLEPAAVRQRTERGVWSPSNNSRHDSAGIRDELAGIGEQIKTLQFQLSSNLSPETKVSEVVTQTLWDLLWRLRTFLFLASPSAAHQWRIGGALFNVYYRRHYGRDAAHVAIALRLYLVLLRFTAVCPAAALHGCLTLFGVLAVLNDPRLRPWKDTSERLLEGFLFVSRALHRSENNVFAQLINVAFELLSEVTAHFNGSAAETESALFLQLSVEPAAELLSQTEGSLPPSASPKSASGAESRARRLQELFSTCTCVETPYEARCIQVCLLRLVVRLSEERLLLSLSPDRVGLLCDVACHLVSSAVPGAEGGVVNRVQHDAAWHTLRHFAVVDRRLLPHIQGPLILSVLAAQWSRRGAQTCSSIFNITVAEKALFDWCRRLSTEELDSLVVAAYHRGGVGPDGQDAMTECLAQMWEVGVQWCADLYTSPSTAVDGIVANTASCSASSVSAMVTLQQWVWLCERVFRSTVAQRSAFAGLTQMGEPKLLAAYDHQLQLLVSELPLSSLTASLLCTQLPSFAVESELAFLPSRILSFFNGQALIACVAEVVDRAKNCIDVSAYRLLEANALAVQSRLKVSSSVVQCDAAAFQSALAETLQVMQHHDAPSYSLLVQAIIVLVHAFPVDSENGEVRKSDTVARVMQALDNSISSRHNGSYAALEVAAPLWHMLDRETAATLFRAGSGLGWTRRLLALPPQTATSATTAELFLCRAAGLAEALQHALEETMLRDGASTSRSTSHSPAPKALPGAVAARGQMPGRLRRVYESIASHFPVVVQLLQTLGALLTTLQRDAQWWRCMRNGKGGTYAEASGAIVALGNFFRHATSILVLLLDAKYRFAVIAGSEAGKGCNGALAGAAPICERSSTTKQPLAQAATVVDVDDDDNADGVFEDNEEAKKPHRHRKATASGATLSSKTGKASAKAAVGGAPQASNLSQQSIAKTKQLEKIVQLNRSKLLPALLAFTRRFVYEGKGRGASPDADEVQNEDGRSSQRAAGSVRNHASALECALLSLAYTSLALSPPFSLNDVNELFSLASVGAYNVKDSILYCALRELVLWSPQLACRECEAGDSAMPTLLLVRLSGTEQLLSTVLSARRDGNTTYIAECGAQILQLLWFGRRFFQRAGDTRAEAADKPEREQRLSLTDASAAVQEDCMAASERVTQEGYAWLCLCFDLYAVYHSVRPAHNDTALAVMGLCVETARGVMAVFSWSATDLLRFRERPFVFSSFFKAIVDKEDRDMKVILTSSLDVLGRYVISAGVDQAGGGTVAATATMSTVVPGDGVTRAKLKHLMDQEKIADWRAAAGALAYALYAYGGKPAAKQMLYLAEAASYAKKSIQDVPSMVRSTIHFVAFHIVSLEADAQMLAYDRRCHSGRDHRRCLSGAAAVHAPLAVVGGSAHSLFVCDRSEGGDGAEAVGVEDASTSPPERTTTGELHAAEGDGGDASASKEVLDGIAFSVFERALEQLVTLGEAAETASAVENSLRKPVVRAVAAEELRKNMFAVLDAVYKAIRIEPAVACRSEGADATDKEEASAAPPVSLRTRRRWLLGLASFIRFMGPQTTPIALMLPTLLGHCARFPSLLPSVCIVWRELICACTDEYLAESAAAIVLSLVSLEQQAALESESKGLLLCALRHLYTRTEAAEFWDSYKVVLGTFSELVRATLHSRHSGCAEAAERSEESRRDSAHVLLLGFASVMRSGSLQSSTVFVRALYQYLCAADEATRRQLSHAAADHPEVLQTLLRCTEADADSALYAMRCISILGAVAAPNAAASTGARWATKTADDERRSSLALSSASALDAWNRMTWTQSFYLDAETVLNWRKFSFTLLRDYFPRVFASTADPVLHNCIAFAVQELIRASTRQERLQHKGVELRREDIVHVDELDRYIWWMRLTPHVKQLLGGFTTTRYSLTVNWQTRLRSPEYTPSLEYRRWLFAFFNHLVMSCEGWFAEMVQPLRNVAKKNASLVLYLLPYLVVHILESGKVEDVQYIEHEVKAVLEAAAGGPNVAVLSLRSQSIYEASPETLSQEEPREHAHTVLSLLEDVEQLRWTLLRNRGRVTCVFEPQEQTESLCIRLAEMYGDFLRGIPWPLRCRAALRIGSHIRALRSVESQRRIPGLASVIAAVPLQRIFAALKDRESSRSIHRASPGLSLEDTAFSFENNGDWLSALGSSELVLQHRPHSGQHQLTALHCMNELGELYMTSRYAASLLASASVSDSDVRGFEAKECLSGAALKGRSTFSQMVSEAPGGAAAVSDFAQLRHHVQAYANEAAWRLGQWDTLLPSSTAASAATAPVNSGMPTVGSDGGRSVSLAMPAAYLQRALSGNGSLAFVRCVTDKERAKVVPLVRTPCQEDLTAQGYTVTLLLHALGDVDAVSELCARAFITNGSGHHCCGDGSDASQSSAPMMKLAAPLLPSSVKEEIASLLSRRESYVEDTIAAREPLLALHRLIYRELDMPQKVAETWLKQSELLRNGGLGEAALTAARQAAFECREHVTATSYYVLVANLLHDTQSPTPAMEFARECVADARIPATTRAQLQILLTNWLIETGSERPEHIFAEYEKARELDRKSELVHHQMALFYDHLHTLASNASEGAAAQLTAAATSPTSSSTANVSAAVMYNAALQHQKEMVDSIQRCATRAIVHFGEALLRGVEKASVSLPRMLTLWLDSAVFLGGLMGTTVGKLDGTTSAVLGEMNNRIREFVLSTVRPVIPPAVVMTALPQLLSRLGHPVTAVRNVLTDIVLHLMDHFPQQCLWLVLPMALSKEGPKEVVETQIIKPFADNPRNERVLRHAKILCDTLLTICNCSASLFPKEKGLTQLSPVQKITPMLATAKFIVPVLSNLTPDIRASSSEDVFPTAPCFDHFDDRVVVMRSLQKPKRIWVHTNDGREMSFLCKAKDEPRKDIRMMEVAALMNSFFLSDPEAKRKRFSLRRYAITALSDDCAVIEWLNDTTPLAKVAMECYALDRSGVHISSVKKWMALVDEKKMSKMELFTKYILPEAPPVMHQWLDRTFASNQSWYEARTLFTQSTALWSIAGHIVGLGDRHAENLMIDMERGELMHVDFACMFDKGEKLEVPEQVRFRLTQNLTDVMGVLGAYGPFQATCEVALRCEMKNKSAVMSIIETLLHEPLMEWRRQSSRSHSSNGPKQLMERVARRLDGFLDLYSVPAQRDTLSLNVESQVAKLIHHSSDLNNLSQMYIWWMAWI
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140.....--.1150......1160......1170......1180......1190......1200......1210......1220......1230--......1240......1250.......1260......1270......1280......1290......1300......1310......1320-------........----1330......1340......1350......1360......1370......1380......1390......1400-........1410......1420......1430-.......1440......1450......1460......1470..---....1480......1490......1500----.......1510......1520......1530......1540......1550......1560......1570......1580......1590-.......1600......1610......1620......1630----.....-.1640......1650......1660......1670--.........1680......-1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850-----......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950........1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250...---...2260......-2270......2280......2290...---...2300...-...2310......2320.......2330......2340---........2350......2360.------.....2370----........2380......2390......2400......-----2410.....----.2420......2430......2440-......2450........2460......2470......2480......2490......2500..--...----.2510......2520......2530......2540......2550..----....2560......2570......2580..--------------------------------....2590......2600......2610..---.......2620......-2630..----------...------.-2640......2650......2660------...----.....2670.-------.....----2680......2690......2700----.------..-----.....2710-----......2720-----......2730......-----------------2740------------------------.........2750.--.--..---...-2760......2770-.----....-..2780...----.----.-.2790......2800......------------2810.--...---..2820......2830..--------------....2840..--....2850......2860--.-....-----------------------.2870.-----------------------..-------------------------------------------------.....-------------------------2880------------------......---.2890.-------.-----.------..-----....--------2900......2910......2920......2930......2940......2950......2960......2970......-------2980..-----------..-----.---.2990---......3000......3010......----3020-..----.----..----....3030......3040......3050......3060......3070......-.-3080........3090......3100----.-----.-------.----.....3110......3120......3130.---....----.---------3140..-------------------------....3150---.--------------.......--------------------------.3160..-----------....3170.....-------.3180---------------.........3190......3200......3210
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEAVIDDEGLE
P
A
A
V
R
Q
R
T
ERGVWSPSNNSRHDSAG
I
R
D
E
L
A
G
I
G
E
Q
I
K
T
L
Q
F
Q
LSSNLSP
E
T
K
V
S
E
V
V
T
Q
T
L
W
D
L
L
W
R
L
R
T
F
L
FLASPSAA
H
Q
WRI
G
G
A
L
F
N
V
Y
Y
R
R
HYGR
D
A
A
H
V
A
I
A
L
R
L
Y
L
V
L
L
R
F
TAV
C
P
A
A
A
L
H
G
C
L
T
L
F
G
V
L
A
V
LNDPRLRPWK
D
T
S
E
R
L
L
E
G
F
L
F
V
S
R
A
L
HRSE
N
N
V
F
A
Q
L
I
N
V
A
F
E
L
L
S
E
V
T
A
HFNGSAAET
E
S
A
L
F
L
Q
L
SV
E
P
A
A
E
L
L
S
Q
TEGSLPPSASPKSAS
G
A
E
S
R
A
R
R
L
Q
E
L
F
S
T
C
TCVETPYE
A
R
C
I
Q
V
C
L
L
R
L
V
V
R
LSE
E
R
L
L
L
S
LSP
D
R
V
G
L
L
C
D
V
A
C
H
L
V
S
S
AVPGAEGGV
V
N
R
V
Q
H
D
A
A
W
H
T
L
R
H
F
A
V
V
D
R
R
L
L
P
HIQ
G
P
L
I
L
S
V
L
A
A
Q
W
S
R
R
G
A
Q
T
C
S
S
I
F
N
I
T
V
A
E
K
A
L
F
D
W
C
R
RL
S
T
E
E
L
D
S
L
V
V
A
A
Y
HRGGVGPD
G
Q
D
A
M
T
E
C
L
A
Q
M
W
E
V
G
V
Q
W
C
A
D
LYTSPSTAVD
G
I
VANTASCSA
S
S
V
S
A
M
V
T
L
Q
Q
W
V
W
L
C
E
R
V
F
R
S
T
V
A
Q
R
S
A
F
AGLTQMGEP
K
L
L
A
A
Y
D
H
Q
L
Q
L
L
V
S
EL
P
L
S
S
L
T
A
S
L
L
C
T
QLP
S
F
A
V
E
S
E
L
A
F
L
P
S
R
I
L
S
F
FN
G
Q
A
L
I
A
C
V
A
E
V
V
D
R
A
KNC
I
D
V
S
A
Y
R
L
LE
A
N
A
L
A
V
Q
S
R
LKVS
S
S
V
V
Q
C
D
A
A
A
F
Q
S
A
L
A
E
T
L
Q
V
M
Q
HHDA
P
S
Y
S
L
L
V
Q
A
I
I
V
L
V
HAFPVDSENGEVRK
S
D
T
V
A
R
V
M
Q
A
L
D
N
S
I
SSRHNGS
Y
A
A
L
E
V
A
A
P
L
W
H
M
L
D
R
E
T
A
A
T
L
F
RAGSGL
G
W
T
R
R
L
LALPPQTATSA
T
T
A
E
L
F
L
C
R
AA
G
L
A
E
A
L
Q
H
A
L
E
E
T
M
L
RDGASTSRSTSHSPAPKAL
P
G
A
V
AARGQM
P
G
R
L
R
R
V
Y
E
S
I
A
S
H
F
P
V
V
V
Q
L
L
Q
T
L
G
A
L
L
T
T
L
Q
R
D
A
Q
W
W
R
C
M
RNGKGG
T
Y
AEAS
G
A
I
V
A
L
G
N
F
F
R
H
A
T
S
I
L
V
L
L
LDAK
Y
R
F
A
V
I
AGSEAGKGCNGALAGAAPICERSSTTKQPLAQA
A
T
V
V
DVDDDDNADGVFED
N
E
E
AKKP
H
R
HRKATASGATLSSKTGKASAKAAVGGAPQASN
L
S
Q
Q
S
I
A
K
T
K
Q
L
E
K
I
V
Q
L
N
R
S
K
L
L
P
A
L
L
A
F
T
R
R
F
V
YEGKGRGASP
D
A
D
E
VQNEDGRS
S
Q
R
AAG
S
V
R
N
H
A
S
A
L
E
C
A
L
L
S
L
A
Y
T
S
LALSPPFSLN
D
V
N
E
L
F
S
L
A
SVGAYNV
K
D
S
I
L
Y
C
A
L
R
E
L
VLWSP
Q
L
A
CRECEAGDSAM
P
T
L
L
L
V
RLS
G
T
E
Q
L
L
S
T
V
L
S
ARRDGN
T
T
Y
I
A
E
C
G
A
Q
I
L
Q
L
L
W
F
G
R
R
F
F
Q
RAGDTRAEAADK
P
E
R
E
Q
RLSL--T
D
A
S
A
A
V
Q
E
D
C
M
A
A
S
E
R
VTQEGY
A
W
L
C
L
C
F
D
L
Y
A
V
Y
H
SVRPAHN
D
T
A
L
A
V
M
G
L
C
V
E
T
AR
G
V
M
A
VFSWS
A
T
D
L
L
R
F
RERP
F
V
F
S
S
F
--
F
K
A
I
VDKEDR
D
M
K
V
I
L
T-S
S
L
D
V
L
G
R
Y
V
I
SAGVDQAGG
G
T
V
A
A
T
A
T
M
S
T
VVPGDGV
T
R
A
K
L
K
H
L
M
D
Q
E
K
I
A
D
W
R
A
A
A
G
A
L
A
Y
A
L
Y
AYGG---------
K
P
A
A
K
Q
M
L
----
Y
L
A
E
A
A
S
Y
A
K
K
S
I
Q
D
V
P
S
M
V
R
S
T
I
H
F
V
A
F
H
I
V
SLEAD
A
Q
M
L
A
Y
D
RRCHSGR
D
H
R
R
C
LSG
A
A
A
V
HA
P
L
A
V
VGG---SA
H
S
L
F
V
C
DRSEGGDGA
E
A
VGVEDASTSPPE--RTTTG
E
L
H
AAEGDGGDA
S
A
S
K
E
V
L
D
G
I
A
F
S
V
F
E
R
A
L
E
Q
L
V
T
LG---
E
A
A
E
T
A
S
A
V
E
N
S
L
R
K
P
V
V
R
A
V
A
A
E
E
L
R
-----
K
N
M
F
A
V
L
D
A
V
Y
K
A
IRIE
P
A
V
A
CRSEGADATDKEEASAAPP
V
S
L
R
T
R
R
R
W
L
L
G
L
A
S
F
I
R
F
MGPQTTP
I
A
L
M
L
P
T
L
L
G
H
C
A
R
F
P
S
L
L
P
S
V
C
I
--
V
W
R
E
L
I
C
A
C
T
D
E
Y
L
A
E
S
A
A
A
I
V
L
S
L
V
S
L
E
Q
Q
A
ALESESK
G
L
----
L
L
C
A
L
-
R
H
L
Y
T
R
T
E
A
A
E
F
W
D
S
Y
K
V
V
L
G
T
F
S
E
L
V
R
A
T
L
H
-----SRHS
G
C
A
E
A
A
E
R
S
E
E
SRRD-SAH
V
L
L
L
G
F
A
S
V
M
RSGSLQ
S
S
T
V
F
V
R
A
L
Y
Q
Y
L
CAA
D
E
A
T
R
R
Q
L
S
H
AAAD
H
P
E
V
L
Q
T
L
L
R
CTEADA
D
S
A
L
Y
A
M
R
C
I
S
I
L
G
A
VAAPNAAASTGARWATKTA
D
D
E
R
R
S
S
LALSS
A
S
A
L
D
A
WNR
M
T
W
T
Q
S
F
Y
L
D
A
E
T
VLNW
R
K
F
S
F
T
L
L
R
D
Y
F
P
R
V
F
ASTA
D
P
V
L
H
N
C
-----
I
A
F
A
V
Q
E
L
I
R
A
S
T
R
Q
E
R
L
Q
HKGVE
L
R
R
E
DIV
H
V
D
E
L
D
R
Y
I
W
W
M
RL
T
P
H
V
K
Q
L
L
GGFT
T
T
R
Y
S
L
T
V
N
W
Q
TRLRSPEYTP
S
L
E
Y
R
R
W
L
F
A
F
F
N
H
L
V
M
S
C
E
--
G
W
F
A
E
M
V
Q
P
L
R
N
V
A
KKNAS
L
V
L
Y
L
L
P
Y
L
V
V
H
I
L
ESGKV
E
D
V
Q
Y
I
E
H
E
V
K
A
V
L
E
AAAGGP
N
V
A
V
L
S
LRSQSIYEASPETL
S
Q
E
E
P
R
E
H
A
H
T
V
L
S
L
L
E
D
V
E
Q
L
R
W
T
L
L
RNRG
R
V
T
C
V
FEP
Q
E
Q
T
E
S
L
C
I
R
L
A
E
M
Y
G
D
F
L
RGIPW
P
L
R
C
R
A
A
L
R
I
G
S
H
I
R
A
L
R
S
V
E
S
QRRI
P
G
L
A
S
V
I
A
A
V
P
L
Q
R
I
F
A
A
L
KDRESSRSIHRASPGLSLED
T
A
F
SFENNG
D
W
L
S
ALGSS
E
L
V
L
QHRPHSGQ
H
Q
L
T
A
L
H
C
M
N
E
L
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F
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---
A
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-
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WRLGQWDTLLPSSTAASAAT---APVNSGMPTV-GSDGG
R
S
V
S
L
AM
P
A
A
Y
-
L
Q
R
A
LSGNG
S
L
A
F
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CVTD-----KER
A
K
V
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P
L
VRTPCQEDLTAQ
G
Y
------
T
V
T
L
L
L
H
------
A
LG
D
V
D
A
V
S
E
L
C
A
R
A
FITNGSGHHCCGDGSDASQSSA
P
-----
M
M
K
L
A
APLL----
P
S
S
V
K
E
E
I
A
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L
L
S
R
R
E
S
Y
V
E
D
T
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AA-R
E
P
L
L
A
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--
R
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ELDM
P
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V
A
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W
L
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L
L
RNGGL
G
E
A
A
L
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A
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F
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HVT
A
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Y
Y
--
V
L
V
----
A
N
L
L
HDTQSPT
P
A
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F
A
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V
ADARIPAT
T
R
A
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L
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I
L
L
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N
W
L
IETGS----ER
P
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--------------------------------
Y
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ASNASEGA
A
A
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AATS---PT---SSSTANV
S
A
A
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M
Y
N
A
A
L
-
Q
H
Q
K
E
M
----------
V
D
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------
I
-
Q
R
C
A
T
R
A
I
V
H
F
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A
L
L
R
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K
A--------SVS----L
P
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M
L
T
L
W
LD-------
S
A
V
F
L
----
G
G
L
M
GTTVGKLDG
T
T
S
A
V
L
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E
M
------
N
------
N
R
-----
I
R
E
F
V
L
S
TV-----RPVI
P
P
A
V
V
M
-----
T
A
L
P
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L
L
S
RLGH
P
V
T
A
-----------------
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---------------------------
R
N
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-
D
--H--
F
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---
Q
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L
W
L
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L
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A
LSKEG--
P
----
K
E
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V
-
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IIKPFA----D----N-P
R
N
E
R
V
L
R
H
A
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I
L
C
D
T
L
L
T
I
C------------NCSAS--LFP---KEKGLTQLS
P
V
Q
K
I
T
P
M
L
--------------
A
T
A
K
F
I
V
P
V
L
--SNLTPDIRASSSEDVFPT--A-P
C
F
D-----------------------HF-D-
D
-----------------------
R
V
-------------------------------------------------
V
V
M
R
S-------------------------LQK-------------------P
K
R
I
W
V
---HT---N-------D-----G------
R
E
-----
M
S
F
L
--------CKAKDEP
R
K
D
I
R
M
M
E
V
A
A
L
M
N
S
FFLSD
P
E
A
K
R
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L
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C
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P
L
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H
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-------
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S
----
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----
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FTQS
T
A
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N
L
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A
-
C
M
FDKGEK-L-E-
V
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P
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M
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L-G-----A-----Y-------G----
P
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A
L
R
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EMK
N
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L
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---
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L
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----
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---------
R
R
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SSR-------------------------SHSSN------
G
--------------
P
K
Q
L
M
E
R
--------------------------
V
A
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R
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YSVPAQR
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HHSS
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L
N
N
L
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M
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I
W
W
M
AWI
58
Fugue
67.30
19%
7
- C3 -
-
4JSP
1
MTOR_HUMAN
A:
[10-1174]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
A
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C
R
A
Y
A
K
A
L
H
Y
K
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F
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N
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L
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Q
-
P
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A
A
A
---
G
V
L
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Y
A
M
K
H
F
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E
L
-
E
I
Q
A
T
W
Y
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D
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KDD
P
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L
M
L
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R
M
R
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-
L
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A
L
G
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W
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W
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V
N
D
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M
A
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A
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W
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L
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W
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M
E
E
Y
T
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M
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P
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T
H
D
G
A
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------
R
A
V
L
A
L
H
Q
DL
F
S
L
A
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Q
C
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A
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D
L
L
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A
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---
S
R
A
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G
A
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-----
M
L
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E
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L
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-
W
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--
S
L
V
V
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----
P
H
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D
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Y
A
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L
L
L
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R
Q
L
D
H
P
L
---------------
P
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----
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---
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A
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L
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L
G
E
W
--------------------------------
Q
L
N
L
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N
E
S
T
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P
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V
L
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Y
Y
S
A
A
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---
D
R
---
S
W
Y
K
A
W
H
A
W
A
V
M
N
F
E
A
V
-
L
H
Y
K
H
Q
----------
N
Q
A
R
D
E
KK
K
V
-
T
E
D
L
S
K
T
L
L
M
Y
T
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P
A
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G
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F
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S
L
S
RGNN
L
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D
----
T
L
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V
L
T
L
W
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-------
Y
G
H
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------------------------
P
D
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------
N
------
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A
-----
L
V
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G
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K
A
----------
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Q
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D
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W
L
-----
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P
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P
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-----------------
V
---------------------------
G
R
L
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-
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--
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--
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---
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----
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----
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-------
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A
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--
Y
F
G
---
E
R
N
V
K
G
M
F
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L
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P
L
H
A
M
M
ERGPQT
L
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--
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Y
-----------------------
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-
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-----------------------
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P
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S
L
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-------------------------
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L
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---
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---
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----
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----
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----
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----
W
F
----
D
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R
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S
M
V
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Y
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L
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L
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L
M
L
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L
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G
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I
L
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-
D
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A
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R
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L
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M
L
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N
A
M
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V
T
-
G
-----
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-----
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-------
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----
N
Y
R
I
T
C
H
T
V
M
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L
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D
S
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M
A
V
L
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A
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D
---
P
L
L
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----
W
---------
R
L
M
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T
N
-------------------------
T
A
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N
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------
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--------------
A
I
Q
I
I
N
R
--------------------------
V
R
D
K
L
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------------------
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D
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-------
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L
D
V
P
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L
L
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L
C
Q
C
Y
I
G
W
C
P
F
W
61
Fugue
55.68
15%
1
- C3 -
-
5FVM
-
?
A:
[85-2469]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
K
A
F
D
L
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F
T
K
L
N
Q
L
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R
V
A
A
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L
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L
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A
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L
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D
N
I
W
R
A
-----------------
L
R
K
L
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A
A
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S
L
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K
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G
C
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T
---------
L
L
V
Y
R
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----
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L
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L
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Y
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Y
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---
A
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L
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---
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V
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L
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L
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L
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H
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K
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L
C
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L
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V
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A
V
A
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A
L
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A
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G
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S
V
V
G
G
E
D
M
----------
L
P
F
L
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L
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P
L
I
I
D
T
F
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D
Q
S
N
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F
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A
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L
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A
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---
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----
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HAVMEQTGIDLPLAN
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--
60
Fugue
52.92
20%
-73
* C3 *
-
4D0L
2
PI4KB_HUMAN
A:
[10-566]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
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----
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-----------------------
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-------------------------------------------------
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----
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-----
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--------------------------
V
E
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-----------
S
M
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S
-------------------------------------------------------------------
57
Fugue
51.38
16%
-10
- C3 -
-
5H64
-
MTOR_HUMAN
A:
[210-2549]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
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K
C
V
Q
F
L
P
Q
V
M
P
T
F
L
N
V
I
R
V
C
D
G
A
I
R
E
F
L
-
F
Q
Q
L
G
M
L
V
S
F
V
K
S
H
I
R
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Y
M
D
E
I
V
T
L
M
R
E
F
W
V
M
N
T
SIQ
S
T
I
I
L
L
I
E
Q
I
V
V
A
L
G
G
E
F
K
L
Y
L
P
Q
L
I
P
H
M
L
R
V
F
M
H
D
N
S
P
G
R
I
V
S
I
K
L
L
A
A
I
Q
L
F
G
A
N
L
D
D
Y
L
H
L
L
L
P
P
I
V
K
L
F
D
A
P
E
--
A
P
L
P
S
R
K
A
A
L
E
T
V
D
R
L
T
E
S
L
D
FT
D
Y
A
S
R
I
I
H
P
I
V
R
T
L
D
Q
S
P
E
L
R
S
T
A
M
D
T
L
S
S
L
V
F
Q
L
G
K
K
Y
Q
I
-
F
I
P
M
V
N
K
V
L
V
R
H
R
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H
Q
R
Y
D
V
L
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C
R
I
V
K
G
Y
T
L
M
K
K
L
H
V
S
T
I
N
L
Q
K
A
W
G
A
A
R
R
V
S
K
D
D
W
L
E
W
L
R
R
L
S
L
E
L
L
K
---
D
S
S
S
P
S
L
R
S
C
W
A
L
A
Q
A
Y
N
P
M
A
R
D
L
--------------
F
N
A
A
F
V
S
C
W
S
E
---------
L
N
E
D
Q
Q
D
E
L
I
R
S
I
E
L
A
L
T
S
Q
D
I
A
E
V
T
Q
T
L
L
N
L
A
E
F
M
E
H
S
D
K
G
P
L
P
L
R
D
D
N
G
I
V
L
L
G
E
R
A
A
K
C
R
A
Y
A
K
A
L
H
Y
K
E
L
E
F
Q
K
G
P
T
P
A
I
L
E
S
L
I
S
I
N
N
K
-------
L
Q
Q
P
E
A
A
A
G
V
L
E
Y
A
M
K
H
F
G
E
L
E
I
Q
A
T
W
Y
E
K
L
HE
W
E
D
A
L
V
A
Y
D
K
K
M
D
-
T
N
K
D
D
P
E
L
M
L
G
R
M
R
C
L
E
A
L
G
E
W
G
Q
L
H
Q
---
Q
C
C
E
K
W
T
L
V
N
-
D
E
T
Q
A
K
M
A
R
M
A
A
A
A
A
W
G
L
G
Q
W
D
S
M
E
E
Y
T
C
M
I
P
--
R
D
-----
T
H
D
G
A
F
Y
R
A
V
L
A
L
H
Q
-
D
L
F
S
L
A
Q
------
Q
C
I
D
K
A
R
------
D
L
L
D
A
E
L
T
A
--------
M
A
G
E
S
Y
S
R
A
Y
G
A
M
V
S
C
H
M
L
S
E
-----
L
E
E
V
I
Q
Y
K
L
----
V
P
E
R
R
E
I
I
R
Q
I
W
W
E
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L
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G
C
Q
R
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D
-
W
Q
K
I
L
M
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R
--
S
L
V
V
S
----
P
H
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D
M
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T
W
L
K
Y
A
S
L
C
G
K
S
G
--
R
L
A
L
A
H
K
T
L
V
L
L
L
G
V
D
P
S
R
Q
L
D
H
P
--
L
-----------
P
T
V
H
P
Q
V
T
Y
A
Y
M
K
N
M
W
K
S
A
R
-
K
I
D
A
F
Q
H
M
Q
H
F
V
Q
T
M
Q
Q
Q
A
Q
H
----
A
I
A
T
E
---
D
Q
Q
H
K
Q
E
L
H
K
L
M
A
R
C
F
L
K
L
G
E
W
--------------------------------
Q
L
N
L
Q
G
I
N
E
S
T
I
P
K
V
L
Q
Y
Y
S
A
A
T
E
H
---
D
R
---
S
W
Y
K
A
W
H
A
W
A
V
M
N
F
E
A
V
-
L
H
Y
K
H
Q
N
Q
A
R
DEKKK
V
T
E
D
------
L
-
S
K
T
L
L
M
Y
T
V
P
A
V
Q
G
F
F
R
S
I
S
L
S
--------
R
G
N
N
L
Q
D
T
L
R
V
L
T
L
W
F
D
YGHW
P
D
V
N
E
A
L
V
----
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
------
D
TPRPL
V
G
R
-----
L
I
H
Q
L
L
T
D
I
GRYHP
Q
A
L
I
Y
P
L
T
V
A
SKSTT
T
A
R
H
N
A
A
N
K
I
L
K
N
M
C
E
-----------------
H
---------------------------
S
N
T
L
V
Q
Q
A
M
M
V
S
-
E
--
E
--
L
I
---
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
--
S
----
R
L
Y
F
-
G
E
R
N
V
K
G
M
F
----
E
VL--
E
-
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
------------
Y
-
G
R
D
--
L
M
E
---
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
--------------
Q
A
W
D
L
Y
Y
H
V
F
--
R
R
I
S
K
Q
L
P
Q
L
T
S
L
E
L
Q
Y
V
--
S
-
P
K
L
L
-----------------------
M
C
-
R
-
D
LELAVPGTYDPNQPIIRIQSIAP
S
L
-------------------------------------------------
Q
V
I
T
S
-------------------------
K
Q
R
-------------------
P
R
K
L
T
L
---
M
G
---
S
-------
N
-----
G
------
H
E
-----
F
V
F
L
--------
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
-------
R
I
M
L
R
M
APD--------
Y
D
-----
H
---
L
T
L
M
Q
---
K
V
E
V
F
E
H
A
V
N
N
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
----
S
----
S
E
----
V
----
W
F
----
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
F
E
V
A
M
T
R
-
E
-
K
-
F
-
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
-
G
-----
L
-----
D
-------
G
----
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
---
P
L
L
N
----
W
---------
R
L
M
D
T
N
-------------------------
T
A
L
N
K
------
K
--------------
A
I
Q
I
I
N
R
--------------------------
V
R
D
K
L
T
G
------------------
R
D
F
S
H
D
-------
D
T
------------------
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
1
PsiBlast_PDB
49.41
27%
-52
- C3 -
-
5FVM
-
?
A:
[2093-2469]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
F
-
E
-
P
-----------------------
V
F
-------------------------------------------------
T
V
I
S
S
-------------------------
K
Q
R
-------------------
P
R
R
V
I
I
---
K
G
---
S
-------
D
-----
G
------
K
D
-----
Y
Q
Y
L
--------
L
K
S
H
E
D
I
R
Q
D
N
L
V
M
Q
L
F
G
L
V
N
T
L
L
Q
N
D
P
E
S
F
Q
R
H
L
N
I
Q
Q
Y
P
A
I
P
L
S
P
K
T
G
L
L
G
W
V
P
N
S
D
T
F
H
V
L
I
R
E
H
R
E
A
S
K
I
P
L
N
I
E
H
-------
R
I
M
L
Q
M
-----------
A
P
-----
D
---
Y
D
N
L
T
L
L
Q
K
V
E
V
F
T
Y
A
L
D
N
T
K
G
Q
D
L
Y
K
V
L
W
L
K
S
R
----
S
----
S
E
----
S
----
W
L
----
D
R
R
T
T
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
I
T
G
K
V
V
H
I
D
F
G
-
D
C
F
E
A
A
I
L
-
R
-
E
K
Y
-
P
E
K
V
P
F
R
L
T
R
M
L
T
Y
A
M
E
V
S
-
G
-----
I
-----
E
-------
G
----
S
F
R
I
T
C
E
N
V
M
M
V
L
R
D
N
K
E
S
L
M
A
I
L
E
A
F
A
Y
D
---
P
L
I
N
----
W
G
F
D
L
P
T
HAV
M
E
Q
T
G
I
-------------------------
D
L
P
L
A
------
N
--------------
P
S
E
L
L
R
K
GV
I
S
V
E
D
A
AKM
E
L
Q
Q
K
A
E
V
R
N
A
R
A
T
L
V
L
K
R
I
A
D
-----------
K
L
T
G
N
D
F
P
R
C
Q
E
----------------------------
L
S
V
P
D
Q
V
D
K
L
I
Q
Q
A
T
S
V
E
N
L
C
Q
H
Y
I
G
W
C
S
--
31
HHSearch
48.89
16%
19
- C3 -
-
4UWH
1
PK3C3_HUMAN
A:
[49-595]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
A
L
T
K
F
L
K
C
V
N
W
D
L
P
Q
E
--------
A
K
Q
----
A
L
E
L
L
G
K
W
K
P
-------
M
D
V
E
D
----
S
L
E
L
----------
L
S
S
--
H
Y
T
------
N
------
P
T
-----
V
R
R
Y
A
V
A
R
L
-----
R
-
Q
A
D
D
E
D
L
L
-----
M
Y
L
L
Q
L
V
Q
A
L
K
Y
E
N
F
D
-----------------
D
I
K
N
G
LEPINSAEIDSSQIITSPLPNLE
Q
D
L
C
T
F
L
I
S
R
A
C
-
K
--
N
S
T
L
A
---
N
Y
L
-
Y
W
Y
V
I
V
E
C
E
D
Q
D
T
Q
Q
R
D
P
K
T
H
E
M
--
Y
L
N
V
M
R
R
F
S
Q
A
L
L
K
GD
K
S
V
-
R
V
M
R
S
L
L
A
A
Q
Q
T
F
V
D
R
L
V
H
L
M
------------
K
A
V
Q
R
--
E
S
G
---
N
R
K
--
K
K
N
E
R
L
Q
A
L
L
G
D
N
--------------
E
--
K
M
N
L
S
D
----
V
E
L
I
P
L
P
L
-------
E
P
--
Q
-
V
K
I
R
-----------------------
G
I
-
I
-
P
E----------------------
T
A
-------------------------------------------------
T
L
F
K
S
-------------------------
A
L
M
-------------------
P
A
Q
L
F
F
---
K
T
---
E
-------
D
-----
G
------
G
K
-----
Y
P
V
I
--------
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
I
I
S
L
M
D
K
L
L
R
K
E
N
----
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
T
K
H
G
F
M
Q
F
I
Q
S
-
V
P
V
A
E
V
L
D
T
E
------
G
---------------------------------------------------------------
S
I
Q
N
F
F
R
K
Y
A
P
----
S
ENGP
N
G
----
I
----
S
A
----
E
V
M
D
T
Y
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
L
T
-
K
T
G
K
L
F
H
I
D
F
G
-
Y
I
L
G
R
D
-----
P
-
K
-
P
L
P
P
P
M
K
L
N
K
E
M
V
E
G
M
G
G
T
-
Q
-----
S
-----
E
-------
Q
Y
Q
--
E
F
R
K
Q
C
Y
T
A
F
L
H
L
R
R
Y
S
N
L
I
L
N
L
F
S
L
M
V
D
A
---
N
I
P
D
----
I
---------
A
L
E
------------------------------------------------------
P
D
K
T
V
K
K
--------------------------
V
Q
D
K
F
R
L
-----------
D
L
S
D
------------------------------------
E
E
A
V
H
Y
M
Q
S
L
I
D
E
S
V
H
-
A
L
F
A
A
---------
62
Fugue
47.06
17%
8
- C3 -
-
4TUU
-
PK3CA_HUMAN
A:
[107-1046]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
E
K
I
L
N
R
E
---
I
G
F
A
I
G
M
P
V
C
-
E
F
D
M
V
K
D
P
E
V
Q
D
F
R
R
N
-
I
L
N
V
C
K
E
A
V
D
L
R
D
L
N
--
S
P
-----
H
S
R
A
M
Y
V
Y
P
P
N
V
E
S
S
P
E
L
P
K
H
I
Y
N
K
LDKG
Q
I
I
V
V
I
W
------
V
I
V
S
P
N
N
D
K
Q
K
Y
T
L
K
I
N
H
D
C
V
P
E
Q
V
I
A
E
A
I
R
K
K
T
R
S
M
L
YQGK
Y
I
L
K
V
C
G
C
D
E
----
Y
F
L
E
K
Y
P
L
S
Q
Y
-----
K
Y
I
R
S
C
I
M
L
G
R
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
P
M
D
C
F
T
M
P
S
Y
S
R
K
S
L
W
V
I
N
S
A
L
-
R
I
K
I
L
C
A
T
Y
V
N
V
N
D
K
I
Y
V
R
T
G
I
Y
H
GG
E
P
L
----
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
L
N
Y
D
I
Y
I
P
D
L
P
R
A
------
A
R
L
C
L
S
I
C
S
----
V
K
E
E
H
C
P
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
P
V
PHGLEDLLNPI
G
V
T
G
S
NPNKETP
C
L
E
L
E
F
D
W
F
S
S
V
V
K
F
P
D
M
S
V
I
E
E
H
A
N
W
S
V
S
---
R
E
A
G
F
S
Y
S
H
A
G
L
S
N
R
L
A
R
D
N
E
L
R
E
N
D
K
E
Q
----------
L
K
A
------
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
--------
C
V
T
----
I
P
E
I
L
P
K
L
L
L
-------
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
P
E
Q
A
M
E
L
L
DCNYP
D
------
P
M
-----
V
R
G
F
A
V
R
C
L
-----
E
K
Y
L
T
D
D
K
L
S
-----
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
-
Q
Y
-----------------
L
---------------------------
D
N
L
L
V
R
F
L
L
K
K
A
-
L
--
T
--
N
Q
---
R
I
G
-
H
F
F
F
W
H
L
K
-
S
E
M
H
--
N
----
K
T
V
S
-
Q
R
F
G
L
L
L
E
S
----
Y
----
C
-
R
A
C
G
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
------------
N
L
T
D
I
--
L
K
Q
---
E
K
K
D
E
T
Q
K
V
Q
M
K
F
L
V
E
Q
M
--------------
R
R
P
D
F
M
D
A
L
Q
--
G
F
L
S
P
L
N
P
A
H
Q
L
G
N
L
R
L
-------------------------------------
E
-----------------------
E
C
-------------------------------------------------
R
I
M
S
S
-------------------------
A
K
R
-------------------
P
--
L
W
L
---
N
W
---
E
-------
N
-----
P
------
D
I
-----
M
S
E
L
LFQ
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
----
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
G
F
N
------------------------------------------------------------------
S
H
T
L
H
Q
W
L
K
D
K
-
N
----
K
----
G
E
----
I
----
Y
D
----
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
-
D
D
G
Q
L
F
H
I
D
F
G
-
H
F
L
D
R
-------------
V
P
F
V
L
T
Q
D
F
L
I
V
I
S
T
K
T
R
-----
E
-----
F
-------
E
----
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
---
G
M
P
E
----
L
---------
Q
S
F
D
D
I
-------------------------
A
Y
I
R
K
T
L
ALDK
T
--------------
E
Q
E
A
L
E
Y
--------------------------
F
M
K
Q
M
N
D
-----------
A
----------------------------------------------------------------------
39
HHSearch
46.70
18%
-21
- C3 -
-
5C46
1
PI4KB_HUMAN
E:
[38-527]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
-----
V
Q
A
Y
I
G
N
R
L
-----
F
-
C
F
R
N
E
D
V
D
-----
F
Y
L
P
Q
L
L
N
M
Y
I
H
M
D
E
D
-----------------
V
---------------------------
G
D
A
I
K
P
Y
I
V
H
R
C
-
R
--
Q
--
S
I
NFS
L
Q
C
-
A
L
L
L
G
A
Y
S
-------------
S
R
--
G
T
K
L
R
K
L
I
L
SD--------------
R
L
A
P
E
R
E
F
I
K
S
L
M
A
I
G
------------
K
R
L
A
T
LP
T
K
E
QKT
Q
R
L
-
I
S
E
L
S
L
L
N
H
K
L
P
A
------------------
R
V
W
L
P
T
A
GF
D
H
H
V
V
R
V
P
H
T
-
Q
A
V
V
L
N
S
KD
K
A
P
Y
L
I
-----------------------
Y
V
-
E
V
L
-----------------------
E
C
-------------------------------------------------
E
N
F
D
T
-------------------------
T
S
V
PARIPDPSAVALKEPWQEK
V
R
R
I
R
E
GSP
Y
G
HL-
P
-------
N
-----
W
------
R
L
-----
L
S
V
I
--------
V
K
C
G
D
D
L
R
Q
E
L
L
A
F
Q
V
L
K
Q
L
Q
S
I
W
E
Q
E
----
R
V
P
L
W
I
K
P
Y
K
I
L
V
I
S
A
D
S
G
M
I
E
P
V
V
N
A
V
S
I
H
Q
V
K
K
Q
S
------
Q
--------------------------------------------------------------
L
S
L
L
D
Y
F
L
Q
E
H
G
SY--
T
----
T
E
----
A
----
F
L
----
S
A
Q
R
N
F
V
Q
S
C
A
G
Y
C
L
V
C
Y
L
L
Q
V
K
D
R
H
N
G
N
I
L
L
D
A
-
E
G
H
I
I
H
I
D
F
G
-
F
I
L
S
S
S
P
-----------
S
A
F
K
L
T
T
E
F
V
D
V
M
G
---
G
-----
L
-----
D
-------
G
DMFN
Y
Y
K
M
L
M
L
Q
G
L
I
A
A
R
K
H
M
D
K
V
V
Q
I
V
E
I
M
Q
Q
G
S--
Q
L
P
C
----
F
---------
H
G
S
--------------------------------------------------------
S
T
I
R
N
--------------------------
L
K
E
R
F
H
M
-----------
S
M
T
------------------
E
------------------
E
Q
L
Q
L
L
V
E
Q
M
V
D
G
S
M
----------------
37
HHSearch
45.98
15%
-39
- C3 -
-
5VLR
1
PK3CD_HUMAN
A:
[527-1008]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
A
L
A
R
L
L
L
V
T
K
W
N
K
H
E
D
--------
V
A
Q
----
M
L
Y
L
L
C
S
W
P
E
-------
L
P
V
L
S
----
A
L
E
------------
L
L
D
F
S
F
P
------
D
------
C
H
-----
V
G
S
F
A
I
K
S
L
-----
R
-
K
L
T
D
D
E
L
F
-----
Q
Y
L
L
Q
L
V
Q
V
L
K
Y
E
S
Y
L
-----------------
D
---------------------------
C
E
L
T
K
F
L
L
D
R
A
L
-
A
N
R
K
--
I
G
---
H
F
L
-
F
W
H
L
R
S
E
M
H
V
P
S
V
-------
A
L
R
--
F
G
L
I
L
E
A
Y
C
----
R
G
S
--
T
-
H
H
M
K
V
L
M
K
Q
-
G
E
A
L
S
K
L
K
A
L
N
------------
D
F
V
K
L
--
S
S
Q
---
K
T
P
K
P
Q
T
K
E
L
M
H
L
C
M
R
Q
------------------
E
A
Y
L
E
A
L
--
S
--
H
L
Q
S
P
L
-------
D
P
--
S
-
T
L
L
A
-----------------------
E
V
C
V
-
E
-----------------------
Q
C
-------------------------------------------------
T
F
M
D
S
-------------------------
K
M
K
-------------------
P
L
W
I
M
Y
---
S
N
EEA----------------------
S
-----
V
G
I
I
--------
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
M
I
Q
L
M
D
V
L
W
K
Q
E
G
----
L
D
L
R
M
T
P
Y
G
C
L
P
T
G
D
R
T
G
L
I
E
V
V
L
R
S
D
T
I
A
N
I
Q
L
N
------------------------------------------------------------
F
N
-------
K
D
A
L
L
N
W
L
K
S
K
N
P
----
G
-----
E
----
A
----
L
D
----
R
A
I
E
E
F
T
L
S
C
A
G
Y
C
V
A
T
Y
V
L
G
I
G
D
R
H
S
D
N
I
M
I
R
-
E
S
G
Q
L
F
H
I
D
F
G
-
H
F
L
G
N
F
-----
I
-
N
-
R
E
R
V
P
F
I
L
T
Y
D
F
V
H
V
I
Q
Q
G
-
K
-----
T
-----
N
NSE
K
F
--
E
----
R
F
R
G
Y
C
E
R
A
Y
T
I
L
R
R
H
G
L
L
F
L
H
L
F
A
L
M
R
A
A
---
G
L
P
E
----
L
---------
S
C
S
--------------------------------------------------------
K
D
I
Q
Y
--------------------------
L
K
D
S
L
A
L
-----------
G
K
T
E
------------------------------------
E
E
A
L
K
H
F
R
V
K
F
N
E
A
L
R
---------------
38
HHSearch
45.80
15%
-31
- C3 -
-
4JPS
1
PK3CA_HUMAN
A:
[561-1048]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
--------
V
A
Q
----
M
Y
C
L
V
K
D
W
P
P
-------
I
K
P
E
Q
----
A
M
E
------------
L
L
D
C
N
Y
P
------
D
------
P
M
-----
V
R
G
F
A
V
R
C
L
-----
E
K
Y
L
T
D
D
K
L
S
-----
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
-----------------
D
---------------------------
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
--
I
G
---
H
F
F
-
F
W
H
L
K
S
E
M
H
N
K
T
V
-------
S
Q
R
--
F
G
L
L
L
E
S
Y
C
R
---
A
----
C
G
M
Y
L
K
H
-
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
T
------------
D
I
L
K
Q
--
E
K
K
---
D
E
T
Q
K
V
Q
M
K
F
L
V
E
Q
M
R
R
-----------------
P
D
F
M
D
A
L
Q
-----
G
F
L
S
P
-------
L
N
P
--
A
-
H
Q
L
G
-----------------------
N
L
-
R
L
E
-----------------------
E
C
-------------------------------------------------
R
I
M
S
S
-------------------------
A
K
R
-------------------
P
L
W
L
N
W
---
E
N
---
P
-------
D
-----
I
MSELLF
Q
N
-----
N
E
I
I
--------
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
----
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
------------------------------------------------------------
F
-------
N
S
H
T
L
H
Q
W
L
K
D
K
N
K
----
G
-----
E
----
I
----
Y
D
----
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
-
D
D
G
Q
L
F
H
I
D
F
G
-
H
F
L
D
H
K
K
K
K
F
G
Y
-
K
-
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
S
K
G
-
A
-----
Q
-----
E
CTKT
R
E
F
E
----
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
---
G
M
P
E
----
L
---------
Q
S
F
--------------------------------------------------------
D
D
I
A
Y
--------------------------
I
R
K
T
L
A
L
-----------
D
K
T
E
------------------------------------
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
---------------
30
HHSearch
43.04
17%
-10
- C3 -
-
5KC2
-
VPS34_YEAST
C:
[338-856]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
A
L
T
K
L
L
Q
S
T
N
L
R
E
E
S
E
--------
R
V
E
----
V
L
E
L
M
D
S
W
A
E
-------
I
D
I
D
D
----
A
L
E
L
L
------------
G
S
T
F
K
------
N
------
L
S
-----
V
R
S
Y
A
V
N
R
L
-----
K
-
K
A
S
D
K
E
L
E
-----
L
Y
L
L
Q
L
V
E
A
V
C
F
E
N
L
S
TFSDKSNSEFTIVDAVS-----------------------------
P
L
A
E
F
L
I
R
R
A
L
----
V
--
N
P
RLG
S
F
F
-
Y
W
Y
L
K
S
E
S
E
D
K
P
Y
------------
L
D
Q
I
L
S
S
F
W
----
S
RL--
D
-
K
K
S
R
N
I
L
N
D
Q
V
R
L
I
N
V
L
R
E
C
C
------------
E
T
I
K
R
--
L
K
D
---
T
T
A
--
K
K
M
E
L
L
V
H
L
L
E
T
-------------------
K
V
R
P
L
V
--
K
V
R
P
I
A
L
P
L
-------
D
P
--
D
-
V
L
I
C
-----------------------
D
V
-
C
-
P
E----------------------
T
S
-------------------------------------------------
K
V
F
K
S
-------------------------
S
L
S
-------------------
P
L
K
I
T
F
---
K
T
---
T
-------
L
-----
N
------
Q
P
-----
Y
H
L
M
--------
F
K
V
G
D
D
L
R
Q
D
Q
L
V
V
Q
I
I
S
L
M
N
E
L
L
K
N
E
N
----
V
D
L
K
L
T
P
Y
K
I
L
A
T
G
P
Q
E
G
A
I
E
F
I
P
N
-
D
T
L
A
S
I
L
S
K
Y
H
-----
G
I
----------------------------------------------------------------
L
G
Y
L
K
L
H
Y
P
----
D
----
E
N
ATLG
V
----
Q
G
----
W
V
L
D
N
F
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
V
T
P
-
D
G
H
F
F
H
A
D
F
G
-
Y
I
L
G
Q
D
-----
P
-
K
-
P
F
P
P
L
M
K
L
P
P
Q
I
I
E
A
F
G
G
A
-
E
-----
S
SN---
Y
-------
D
----
K
F
R
S
Y
C
F
V
A
Y
S
I
L
R
R
N
A
G
L
I
L
N
L
F
E
L
M
K
T
S
---
N
I
P
D
----
I
---------
R
I
D
------------------------------------------------------
P
N
G
A
I
L
R
--------------------------
V
R
E
R
F
N
L
-----------
N
M
S
E
------------------------------------
E
D
A
T
V
H
F
Q
N
L
I
N
D
S
V
N
---------------
32
HHSearch
42.73
17%
-9
- C3 -
-
5DFZ
-
VPS34_YEAST
C:
[338-856]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
A
L
T
K
L
L
Q
S
T
N
L
R
E
E
S
E
--------
R
V
E
----
V
L
E
L
M
D
S
W
A
E
-------
I
D
I
D
D
----
A
L
E
L
L
----------
G
--
S
T
F
K
------
N
------
L
S
-----
V
R
S
Y
A
V
N
R
L
-----
K
-
K
A
S
D
K
E
L
E
-----
L
Y
L
L
Q
L
V
E
A
V
C
F
E
N
L
S
TFSDKSNSEFTIVDAVS------------------------------
P
L
A
E
F
L
I
R
R
A
-
L
--
V
--
N
P
RLG
S
F
F
-
Y
W
Y
L
K
S
E
S
E
D
K
P
Y
------------
L
D
Q
I
L
S
S
F
W
----
S
RL--
D
-
K
K
S
R
N
I
L
N
D
Q
V
R
L
I
N
V
L
R
E
C
C
------------
E
T
I
K
R
--
L
K
D
---
T
T
--
A
K
K
M
E
L
L
V
H
L
L
E
T
-------------------
K
V
R
P
L
V
--
K
V
R
P
I
A
L
P
L
-------
D
P
--
D
-
V
L
I
C
-----------------------
D
V
-
C
-
P
E----------------------
T
S
-------------------------------------------------
K
V
F
K
S
-------------------------
S
L
S
-------------------
P
L
K
I
T
F
---
K
T
---
T
-------
L
-----
N
------
Q
P
-----
Y
H
L
M
--------
F
K
V
G
D
D
L
R
Q
D
Q
L
V
V
Q
I
I
S
L
M
N
E
L
L
K
N
E
N
----
V
D
L
K
L
T
P
Y
K
I
L
A
T
G
P
Q
E
G
A
I
E
F
I
P
N
-
D
T
L
A
S
I
L
S
K
Y
H
-----
G
I
----------------------------------------------------------------
L
G
Y
L
K
L
H
Y
P
----
D
----
E
N
----
A
TLGV
Q
G
----
W
V
L
D
N
F
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
V
T
P
-
D
G
H
F
F
H
A
D
F
G
-
Y
I
L
G
Q
D
-----
P
-
K
-
P
F
P
P
L
M
K
L
P
P
Q
I
I
E
A
F
G
G
A
-
E
-----
S
SN---
Y
-------
D
----
K
F
R
S
Y
C
F
V
A
Y
S
I
L
R
R
N
A
G
L
I
L
N
L
F
E
L
M
K
T
S
---
N
I
P
D
----
I
---------
R
I
D
------------------------------------------------------
P
N
G
A
I
L
R
--------------------------
V
R
E
R
F
N
L
-----------
N
M
S
E
------------------------------------
E
D
A
T
V
H
F
Q
N
L
I
N
D
S
V
N
---------------
11
PsiBlast_PDB
42.10
25%
-15
- C3 -
-
5W1R
-
?
A:
[3722-4127]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
D
-
E
-----------------------
R
V
-------------------------------------------------
T
V
M
A
S
-------------------------
L
R
R
-------------------
P
K
R
I
I
I
---
R
G
---
H
-------
D
-----
E
------
R
E
-----
H
P
F
L
--------
V
K
G
G
E
D
L
R
Q
D
Q
R
V
E
Q
L
F
Q
V
M
N
G
I
L
A
Q
D
S
A
C
S
Q
R
A
L
Q
L
R
T
Y
S
V
V
P
M
T
S
R
L
G
L
I
E
W
L
E
N
T
V
T
L
K
D
L
L
L
N
T
M
S
Q
E
E
K
A
A
Y
L
S
D
P
R
A
P
P
C
E
Y
K
D
W
L
T
K
M
SGKHDVGAY
M
L
-----
M
---
Y
K
G
A
N
---
R
T
E
T
V
T
S
F
R
K
R
E
S
-
K
V
P
A
D
L
L
K
R
A
F
V
R
M
ST
S
----
P
E
----
A
----
F
L
----
A
L
R
S
H
F
A
S
S
H
A
L
I
C
I
S
H
W
I
L
G
I
G
D
R
H
L
N
N
F
M
V
A
M
E
T
G
G
V
I
G
I
D
F
G
-
H
A
F
G
S
A
T
Q
F
L
-
P
-
V
-
P
E
L
M
P
F
R
L
T
R
Q
F
I
N
L
M
L
P
M
-
K
-----
E
-----
T
-------
G
----
L
M
Y
S
I
M
V
H
A
L
R
A
F
R
S
D
P
G
L
L
T
N
T
M
D
V
F
V
K
E
---
P
S
F
D
----
W
---------
K
N
F
E
Q
K
-------------------------
M
L
K
K
G
------
G
SWIQEINVAEKNWY
P
R
Q
K
I
C
Y
--------------------------
A
K
R
K
L
A
G
ANPA
V
I
T
C
D
E
L
L
L
G
H
E
K
A
P
A
F
R
D
Y
-------
V
A
V
A
R
G
SKDHNIRAQEPESG
L
S
E
E
T
Q
V
K
C
L
M
D
Q
A
T
D
P
N
I
L
G
R
T
W
E
G
W
E
P
W
-
34
HHSearch
40.72
17%
-26
- C3 -
-
2X6H
-
?
B:
[660-942]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Y
I
T
-----------------------
K
I
-
V
-
P
M----------------------
R
T
-------------------------------------------------
S
L
F
K
S
-------------------------
A
L
M
-------------------
P
A
K
L
T
F
---
V
T
---
S
-------
I
A----
H
------
H
E
-----
Y
A
A
I
--------
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
M
I
T
L
M
D
K
L
L
R
R
E
N
----
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
S
K
H
G
F
L
Q
Y
V
D
S
-
C
T
V
A
E
V
L
A
R
E
---------------------------------------------------------------------
G
N
I
H
N
F
F
R
K
H
H
P
----
C
----
D
N
----
G
----
P
Y
GIS
A
E
V
M
D
T
Y
I
K
S
C
A
G
Y
C
V
I
T
Y
L
L
G
V
G
D
R
H
L
D
N
L
L
L
T
-
T
N
G
K
L
F
H
I
D
F
G
-
Y
I
L
G
R
D
-----
P
-
K
-
P
M
P
P
P
M
K
L
S
K
E
M
V
E
A
M
G
G
I
-
S
-----
S
-----
E
H
H
-----
H
----
E
F
R
K
Q
C
Y
T
A
Y
L
H
L
R
R
H
A
N
V
M
L
N
L
F
S
L
M
V
D
A
---
T
V
P
D
----
I
---------
A
L
E
------------------------------------------------------
P
D
K
A
V
K
K
--------------------------
V
E
E
N
L
Q
L
-----------
G
L
T
D
------------------------------------
E
E
A
V
Q
H
L
Q
S
L
L
D
V
S
I
T
-
A
V
M
P
A
L
V
E
Q
I
H
R
--
65
Fugue
40.17
36%
-146
- C3 -
-
1W1N
-
A:
[1-33]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
------------------
L
D
V
P
E
Q
V
D
K
L
I
Q
Q
A
T
S
I
E
R
L
C
Q
H
Y
I
G
W
C
P
F
W
59
Fugue
39.97
12%
-11
- C3 -
-
1E8X
1
PK3CG_PIG
A:
[1-951]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
S
E
E
T
---
L
A
F
Q
R
Q
L
N
A
L
I
G
Y
D
V
T
D
V
S
N
V
H
D
D
E
L
E
-
F
T
R
R
R
L
V
T
P
R
M
A
E
V
A
G
R
D
P
-----
K
L
Y
A
M
H
P
W
V
T
S
K
P
L
P
E
Y
L
L
K
K
I
T
------
N
N
C
V
F
I
V
------
I
H
R
S
T
T
S
Q
T
I
K
V
S
A
D
D
T
P
G
T
I
L
Q
S
F
F
T
K
M
A
N
E
R
D
F
V
L
R
-----
V
C
G
R
D
E
Y
L
V
----
G
E
T
P
I
K
N
F
Q
W
V
R
Q
C
L
K
N
G
E
E
I
H
L
V
L
-
D
T
P
P
D
P
A
L
--
D
E
V
R
K
E
C
D
R
K
F
R
V
K
I
R
G
I
D
I
P
V
L
P
R
T
A
D
L
T
V
F
V
E
A
N
I
Q
Y
G
Q
Q
V
L
C
Q
R
R
T
S
P
K
P
F
--
T
E
E
----
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
Q
L
L
Y
Y
V
N
L
L
L
I
D
H
R
-
F
L
L
R
----
H
G
E
Y
V
L
H
M
W
Q
L
S
G
F
N
A
D
K
L
T
S
A
T
N
P
D
K
E
N
S
--------------------------------
M
S
I
S
I
L
L
D
N
H
P
I
A
L
E
M
P
N
Q
L
R
K
Q
L
E
---
A
I
---
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
-
W
H
F
R
Y
E
----------
S
L
K
------
D
-
P
K
A
Y
P
K
L
F
----
S
S
V
K
W
G
Q
Q
E
I
--------
V
A
K
----
T
Y
Q
L
L
A
K
R
E
V
-------
W
D
Q
-----------
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
------
D
------
E
N
-----
V
R
A
I
A
V
Q
K
L
-----
E
S
-
L
E
D
D
D
V
L
-----
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
-----------------
D
---------------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
--
K
--
R
I
---
G
H
F
-
L
F
W
F
L
R
S
E
I
A
Q
S
R
--
H
----
Y
Q
Q
R
-
F
A
V
I
L
E
A
Y
L
----
R
G
C--
G
-
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
D
M
L
Q
K
V
T
------------
I
D
I
K
S
--
L
-
S
---
A
E
K
Y
D
V
S
S
Q
V
I
S
Q
L
K
Q
K
L
--------------
E
N
L
Q
N
L
N
L
P
Q
--
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
V
------------------------------------
I
-
E
-----------------------
K
C
-------------------------------------------------
K
V
M
A
S
-------------------------
K
K
K
-------------------
P
L
W
L
E
F
---
K
C
---
A
-------
D
PTALS
N
------
E
T
-----
I
G
I
I
--------
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
----
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
N
T
G
------------------------------------------------------------
A
F
K
D
E
V
L
S
H
W
L
K
E
K
C
P
----
I
----
E
E
----
K
----
F
Q
----
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
S
-
E
T
G
N
L
F
H
I
D
F
------------------
G
H
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
-
G
KKTS
L
H
-----
F
-------
Q
----
K
F
Q
D
V
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
---
G
M
P
Q
----
L
---------
T
S
K
E
D
I
-------------------------
E
Y
I
R
D
A
L
----
T
--------------
V
G
K
S
E
E
D
--------------------------
A
K
K
Y
F
L
D
-----------
Q
I
E
V
C
R
D
K
G
W
T
V
Q
-------
F
N
------------------
W
F
L
H
L
V
L
------------------------
20
PsiBlast_PDB
39.05
24%
-28
- C3 -
-
3APF
1
PK3CG_HUMAN
A:
[663-877]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------
K
C
-------------------------------------------------
K
V
M
A
S
-------------------------
K
K
K
-------------------
P
--
L
W
L
---
E
F
---
K
CADPTAL
S
-----
N
------
E
T
-----
I
G
I
I
--------
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
----
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
------------
S
T
-------
V
G
N
T
G
A
-----------
F
K
-----
D
---
E
----------------------
V
L
N
H
W
L
K
E
K
S
P
----
T
----
E
E
----
K
----
F
Q
----
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
-
T
E
T
G
N
L
F
H
I
D
F
G
-
H
I
L
G
N
--------
N
-
K
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
-
G
-----
K
K
T
S
P
H
F
-------
Q
----
K
F
Q
D
I
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
38.64
17%
-32
- C3 -
-
2X6K
1
?
A:
[407-689]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Y
I
T
-----------------------
K
I
-
V
-
P
M----------------------
R
T
-------------------------------------------------
S
L
F
K
S
-------------------------
A
L
M
-------------------
P
A
K
L
T
F
---
V
T
---
S
-------
I
A----
H
------
H
E
-----
Y
A
A
I
--------
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
M
I
T
L
M
D
K
L
L
R
R
E
N
----
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
S
K
H
G
F
L
Q
Y
V
D
S
-
C
T
V
A
E
V
L
A
R
E
---------------------------------------------------------------------
G
N
I
H
N
F
F
R
K
H
H
P
----
C
----
D
N
----
G
----
P
Y
GIS
A
E
V
M
D
T
Y
I
K
S
C
A
G
Y
C
V
I
T
Y
L
L
G
V
G
D
R
H
L
D
N
L
L
L
T
-
T
N
G
K
L
F
H
I
D
F
G
-
Y
I
L
G
R
D
-----
P
-
K
-
P
M
P
P
P
M
K
L
S
K
E
M
V
E
A
M
G
G
I
-
S
-----
S
-----
E
H
H
-----
H
----
E
F
R
K
Q
C
Y
T
A
Y
L
H
L
R
R
H
A
N
V
M
L
N
L
F
S
L
M
V
D
A
---
T
V
P
D
----
I
---------
A
L
E
------------------------------------------------------
P
D
K
A
V
K
K
--------------------------
V
E
E
N
L
Q
L
-----------
G
L
T
D
------------------------------------
E
E
A
V
Q
H
L
Q
S
L
L
D
V
S
I
T
-
A
V
M
P
A
L
V
E
Q
I
H
R
--
16
PsiBlast_PDB
36.92
24%
-28
- C3 -
-
4ANW
1
PK3CG_HUMAN
A:
[661-875]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------
K
C
-------------------------------------------------
K
V
M
A
S
-------------------------
K
K
K
-------------------
P
--
L
W
L
---
E
F
---
K
CADPTAL
S
-----
N
------
E
T
-----
I
G
I
I
--------
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
----
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
------------
S
T
-------
V
G
N
T
G
A
-----------
F
K
-----
D
---
E
----------------------
V
L
N
H
W
L
K
E
K
S
P
----
T
----
E
E
----
K
----
F
Q
----
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
-
T
E
T
G
N
L
F
H
I
D
F
G
-
H
I
--------------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
-
G
-----
K
KTS
P
H
F
-------
Q
----
K
F
Q
D
I
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
36.53
24%
-22
- C3 -
-
3APD
1
PK3CG_HUMAN
A:
[663-877]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------
K
C
-------------------------------------------------
K
V
M
A
S
-------------------------
K
K
K
-------------------
P
--
L
W
L
---
E
F
---
K
C
ADPTAL
S
-----
N
------
E
T
-----
I
G
I
I
--------
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
----
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
------------
S
T
-------
V
G
N
T
G
A
-----------
F
K
-----
D
---
E
----------------------
V
L
N
H
W
L
K
E
K
S
P
----
T
----
E
E
----
K
----
F
Q
----
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
-
T
E
T
G
N
L
F
H
I
D
F
G
-
H
I
L
G
N
--------
N
-
K
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
-
G
-----
K
KTS
P
H
F
-------
Q
----
K
F
Q
D
I
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------