@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_33_1810: (2018-03-12 )
MSKEAAKTPREDGGVARKGDGKAPKKLIGGHIELGHVLGVGGFGKVYNAYDVTKKVHVAVKMIDKALVRSSGIQSYVEREIEMMRKMKNQHVVRLLEAIETSKAYNLVMELAPNGELFDKIVDSKRFDEETARNYFQQLICAVHYCHRMNIVHRDLKAENLLLGENNVLKVCDFGLSRYTKEGRFNDHEVLFTSLAGSIDYQAPEVLKERGYEGDSCDMWSCGCVLFFMLCGYLPFTDRSDGLTRKRIMSCQYNKTSRYLPEQAADLIAHLLVPFPSARYTTSDVIQHPWFRVNLDPSMFPDDNVVPTPMSPLGNGEFIQRVITPQMSSGSFGAAPSPTTSKADEMHQAFQSCNITGDGFLNKEEVRDALIKLNGGNQVTEQEVKDFMSNFQVDQEGRITEEEFVMGWTKHQNDLGSKYDLSKMAHLFHYDLEKEFLQVVREAFDLIDSEHSGIITKEKLKSLNLGLTDKDAESAFSSMDTEHRGLSSLTFEGFVGLCLKYDFFKNHPLAIRLRRLNAFFEATEHTAFRASLNTGYTVAGQREVIKALLLSKQESLSTTFEEGDGNGFLYGTYTQDSKKVLEIGVRLLPAAAGYTKVIVYRIGGKTIEFHKWFLDLRRLMKDELLRCEEDTAVKGEPELM
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160..---..---.---.---.170......-.180.......190.......200.......210.......220.......230.......240........250..---..---.---..260.......270.......280.......290.-----......300......-----.----310-.----..----.-.-....320--......--.330.......340.......350.......360....--------------...370...---------.------..-------.------------380.......390.......400.......410.......420.......430.......440.......450.......460..--.....470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSKEAAKTPREDGGVARKGDGKA
P
K
K
L
IGGH
I
E
L
G
H
V
L
GVGGFG
K
V
Y
N
A
Y
D
V
T
K
K
V
H
V
A
V
K
M
I
D
K
A
L
V
R
S
S
G
I
Q
S
Y
V
E
R
E
I
E
M
M
R
K
M
K
N
Q
H
V
V
R
L
L
E
A
I
ETS
K
A
Y
N
L
V
M
E
LAP
N
G
E
L
F
D
K
I
V
D
SKRF
D
E
E
T
A
R
N
Y
F
Q
Q
L
I
C
A
V
H
Y
C
H
R
M
N
I
V
H
R
DLKAE
N
L
L
LG---EN---
N
---
V
---
L
K
V
C
D
F
G
L
S
R-YTKEGRFN
D
H
E
V
L
F
T
S
LAGSIDYQ
A
P
E
V
L
K
ERGYEGDSCDMW
S
C
G
C
V
L
F
F
M
L
CGYLPFTDRS-DGL
T
R
K
R
I
M
S
C
QYN---
K
T
---S---RY
L
P
E
Q
A
A
D
L
I
A
H
L
LVPFPSARYT
T
S
D
V
IQHP
W
F
R
V
-----NLDPSMFPDDNVVPT-----P----M---S----PL----G-
N
-
G
E
F
I
Q
R
V
--ITPQMS--SGSFGAAPSPTT
S
K
A
D
E
M
H
Q
A
F
Q
SCNITGDGFL
N
K
E
E
V
--------------
R
D
A
L
I
KLNG---------G------NQ-------V------------
T
E
Q
E
V
K
D
F
M
S
NFQVDQEGRI
T
E
E
E
F
V
M
G
W
TKHQNDLGSKY
D
L
S
K
M
A
H
L
F
H
Y
D
L
E
K
E
F
L
Q
V
V
R
E
A
F
D
L
IDSEHSGI
I
T
K
E
K
L
K
S
LN--LGLTD
K
D
A
E
S
A
F
S
SM
D
T
E
HRGLSSL
T
F
E
G
F
V
G
L
C
L
K
Y
D
F
FKNH
P
L
A
I
R
L
R
R
L
N
A
F
F
E
ATEH
T
A
F
R
A
SLNT
G
Y
T
VA
G
Q
R
E
V
I
K
A
L
L
L
S
K
Q
E
S
LS
T
T
FEEGDGN
G
F
L
Y
G
T
YTQ
D
S
K
K
V
L
E
I
G
V
R
LLPAAAG
Y
T
K
V
I
V
Y
R
IGG
K
T
I
E
F
H
K
W
F
L
D
L
R
R
L
M
K
D
E
L
L
RCEEDTAVKGEPELM
27
HHSearch
75.66
27%
-18
- C1 -
-
4YSM
-
?
B:
[22-485]
---------------------
Q
H
S
T
A
A
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
K
R
Q
V
K
Q
K
T
D
K
E
L
L
L
K
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
NKR
K
D
---
A
---
N
---
I
R
I
I
D
F
G
L
S
T
-
H
F
E
S
T
K
------
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
F
D
I
L
K
K
V
E
K
G
K
F
T
---
F
D
LPQ
W
---
K
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
A
L
E
H
E
W
L
K
T
-----
T
D
A
A
T
D
S
I
D
V
P
S
L
E
S
-----
T
----
I
LNI
R
----
Q
F
----
Q
G
T
-
Q
K
L
A
A
A
A
--
L
L
Y
---------
M
G
S
K
L
T
T
N
E
E
T
V
E
L
N
K
I
F
Q
R
M
D
K
N
G
D
G
Q
L
D
K
Q
E
L
--------------
M
E
G
Y
V
E
L
M
K
LKGEDVSAL
D
------
Q
S
-------
A
------------
I
E
F
E
V
E
Q
V
L
D
A
V
D
F
D
K
N
G
F
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
--------------------
S
R
Q
R
L
E
R
A
F
G
M
F
D
A
D
G
S
G
K
I
S
S
S
E
L
A
T
I
F
GV
S
E
V
D
S
E
T
W
R
R
V
L
A
E
V
D
R
N
N
--
D
G
E
V
D
F
E
E
F
R
Q
M
L
L
K
L
-------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
73.36
27%
-28
- C1 -
-
3NYV
1
?
A:
[19-481]
----------------------
H
S
T
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
SKS
K
D
---
A
---
N
---
I
R
I
I
D
F
G
L
S
T
-
H
F
E
A
S
K
------
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
---
F
E
L
P
Q
W
---
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
-----
Y
T
K
-----
D
V
P
S
L
D
N
-----
A
I
L
N
I
R
---
Q
----
F
Q
----
G
-
T
-
Q
K
L
A
Q
A
A
--
L
L
Y
M
---------
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
--------------
I
E
G
Y
K
E
L
M
R
----------DASMLD
A
S
-------
A
------------
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
--------------------
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
--
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
-------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
72.21
28%
-8
- C1 -
-
4Y5Q
1
?
A:
[15-481]
----------------------
Y
F
Q
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
K
D
-
T
S
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
SKE
K
D
---
C
---
D
---
I
K
I
I
D
F
G
L
S
T
-
C
F
Q
Q
N
T
---------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
--
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
-
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
---
F
D
L
P
Q
W
---
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
-----
Y
S
S
E
T
P
T
I
S
D
--
L
P
S
-----
L
----
E
---
S
----
A
-------
M
-
T
N
I
R
Q
F
Q
--
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
--------------
V
R
G
Y
H
E
F
M
R
---------
L
------
K
G
VDSNSGS
T
------------
I
E
D
Q
I
D
S
L
M
P
L
L
D
M
D
G
S
G
S
I
E
Y
S
E
F
I
A
S
A
I
D
R
T
I
L
L
--------------------
S
R
E
R
M
E
R
A
F
K
M
F
D
K
D
G
S
G
K
I
S
T
K
E
L
F
K
L
F
S-------------
E
Q
V
D
N
N
K
--
D
G
E
V
D
F
N
E
F
V
E
M
L
Q
N
--------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
70.04
40%
-146
- C1 -
-
5ISO
2
?
A:
[14-370]
-----------------------------
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
---
A
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
-
M
M
S
D
G
E
F
-----
L
R
T
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
-
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
----
I
---
P
---
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
-----
D
L
P
S
Y
L
F
P
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
69.94
27%
-34
- C1 -
-
5T6A
1
?
A:
[63-522]
-------------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
SKS
K
D
---
A
---
N
---
I
R
I
I
D
F
G
L
S
T
-
H
F
E
A
-------
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
---
F
E
---
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
-----
Y
T
K
-------
P
S
L
D
N
-----
A
----
I
---
L
N
I
R
Q
F
Q
----
G
-
T
-
Q
K
L
A
Q
A
A
--
L
L
Y
---------
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
--
G
D
G
Q
L
-
R
A
E
L
--------------
I
E
G
Y
K
E
L
M
---------------------------------------
V
E
H
E
V
D
Q
V
L
D
A
V
D
-------
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
--------------------
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
--
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
-------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
69.85
27%
-
- C- -
-
4RGJ
-
CDPK4_PLAF7
A:
[65-524]
--------------------------
V
F
N
E
Q
Y
K
G
I
K
I
L
G
K
G
S
F
G
E
V
I
L
S
R
D
K
H
T
G
H
E
Y
A
I
K
V
I
S
K
K
H
V
K
R
K
T
D
K
E
S
L
L
R
E
V
E
L
L
K
M
L
D
H
I
N
I
M
K
L
Y
E
F
F
E
D
N
N
Y
Y
Y
L
V
S
D
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
Y
E
I
D
A
A
R
I
I
K
Q
I
L
S
G
I
T
Y
M
H
K
N
N
V
V
H
R
D
L
K
P
E
N
I
L
L
E
---
T
-----M--
I
---
I
K
I
I
D
F
G
L
S
T
-
H
F
E
-------------
K
I
G
T
A
Y
Y
I
A
P
D
V
L
H
G
--
T
Y
D
E
K
C
D
I
W
S
C
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
S
N
-
E
Y
D
I
L
K
K
V
E
A
G
K
Y
T
---
F
D
L--
P
QF-
K
K
I
S
D
K
A
K
D
L
I
K
K
M
L
M
Y
T
S
A
V
R
I
S
A
R
D
A
L
E
H
E
W
I
K
M
-----
M
T
S
K
--------
L
E
L
-----
S
----
I
---
A
N
I
R
Q
F
Q
----
S
-
T
-
Q
K
L
A
Q
A
A
--
L
-
L
Y
--------
M
G
S
K
L
T
T
I
D
E
T
K
E
L
T
K
I
F
K
K
M
D
K
N
G
D
G
Q
L
D
R
N
E
L
--------------
I
I
G
Y
K
E
L
L
K
L
K
-------
G
------
E
D
--------S
D
L
D
N
A
A
-----
I
E
Y
E
V
D
Q
I
L
N
S
I
D
L
D
Q
N
G
Y
I
E
Y
S
E
F
L
T
V
S
I
D
R
K
L
L
L
--------------------
S
T
E
R
L
E
K
A
F
K
L
F
D
K
D
G
S
G
K
I
S
A
N
E
L
A
Q
L
F
G
L
S
D
V
S
S
E
C
W
K
T
V
L
K
E
V
D
Q
N
N
--
D
G
E
I
D
F
K
E
F
R
D
M
L
V
K
--------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
69.55
38%
-150
- C1 -
-
4ZHX
2
AAPK2_HUMAN
A:
[22-426]
--------------------
G
R
V
--
K
I
--
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
---
A
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
-
M
M
S
D
G
E
F
------
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
-
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
----
I
---
P
---
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
-----
G
L
P
S
Y
L
F
P
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
68.40
28%
-6
- C1 -
-
3Q5I
1
?
A:
[29-498]
----------------------
K
K
E
G
K
I
G
E
S
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
------
K
F
H
E
E
I
Y
N
E
I
S
L
L
K
S
L
D
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
H
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
---
N
K
---
N
SLL
N
---
I
K
I
V
D
F
G
L
S
S
-
F
F
S
K
D
------
Y
K
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
K
--
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
N
-
D
Q
D
I
I
K
K
V
E
K
G
K
Y
Y
---
F
D
FND
W
---
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
A
L
N
S
R
W
I
K
K
-----
Y
A
N
N
I
N
K
S
D
Q
K
T
L
C
G
-----
A
L
S
N
-
M
---
R
K
---
F
E
----
G
-
S
-
Q
K
L
A
Q
A
A
--
I
L
F
---------
I
G
S
K
L
T
T
L
E
E
R
K
E
L
T
D
I
F
K
K
L
D
K
N
G
D
G
Q
L
D
K
K
E
L
--------------
I
E
G
Y
N
V
L
R
N
F
KLG-----
E
------
L
K
-------
N
------------
V
E
E
E
V
D
N
I
L
K
E
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
I
S
V
C
M
D
K
Q
I
L
F
--------------------
S
E
E
R
L
R
R
A
F
N
L
F
D
T
D
K
S
G
K
I
T
K
E
E
L
A
N
L
F
GL
T
S
I
S
E
K
T
W
N
D
V
L
G
E
A
D
Q
N
K
--
D
N
M
I
D
F
D
E
F
V
S
M
M
H
K
I
-------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
67.89
39%
-142
- C1 -
-
4CFF
2
AAPK2_HUMAN
A:
[33-418]
-----------------------------
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
---
A
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
-
M
M
S
D
G
E
F
------
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
-
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
----
I
---
P
---
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
-----
D
L
P
S
Y
L
F
P
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
67.83
28%
-10
- C1 -
-
3MWU
1
?
A:
[15-482]
----------------------
Y
F
Q
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
K
D
-
T
S
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
SKE
K
D
---
C
---
D
---
I
K
I
I
D
F
G
L
S
T
-
C
F
Q
Q
N
----------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
--
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
-
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
---
F
D
L
P
Q
W
---
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
-----
Y
S
S
E
T
P
T
I
S
D
--
L
P
S
-----
L
----
E
---
S
----
A
-------
M
-
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
--
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
--------------
V
R
G
Y
H
E
F
M
R
---------
L
------
K
G
-------
V
DSNSLIQNEGST
I
E
D
Q
I
D
S
L
M
P
L
L
D
M
D
G
S
G
S
I
E
Y
S
E
F
I
A
S
A
I
D
R
T
I
L
L
--------------------
S
R
E
R
M
E
R
A
F
K
M
F
D
K
D
G
S
G
K
I
S
T
K
E
L
------------------
E
Q
V
D
N
N
K
--
D
G
E
V
D
F
N
E
F
V
E
M
L
Q
N
F
-------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
66.92
39%
-142
- C1 -
-
4CFE
2
AAPK2_HUMAN
A:
[33-417]
-----------------------------
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
---
A
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
-
M
M
S
D
G
E
F
------
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
-
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
----
I
---
P
---
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
-----
D
L
P
S
Y
L
F
P
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
65.35
38%
-135
- C1 -
-
4RED
-
AAPK1_HUMAN
A:
[16-289]
-----------------------------
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
A
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
---
A
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
-
M
M
S
D
---------------
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
-
V
P
T
L
F
K
K
----
I
F
----
Y
T
---
P
---
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
K
D
I
R
E
H
E
W
F
K
Q
-----
D
L
P
K
Y
L
F
P
E
D
P
S
Y
S
T
-----
T
----
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
65.05
29%
-13
- C1 -
-
3LIJ
1
?
A:
[31-489]
-----------------------
K
K
G
H
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
-----
S
S
-
N
S
K
L
L
E
E
V
A
V
L
K
L
L
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
---
S
K
---
E
KD
A
L
---
I
K
I
V
D
F
G
L
S
A
-
V
F
E
N
Q
------
K
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
K
--
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
-
D
Q
E
I
L
R
K
V
E
K
G
K
Y
T
---
F
D
---
S
PEW
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
E
-----
M
C
S
K
K
E
S
----
L
P
S
L
A
N
A
I
E
N
----
M
---
R
----
K
F
----
Q
-
N
S
Q
K
L
A
Q
A
A
--
L
L
Y
---------
M
A
S
K
L
T
S
Q
E
E
T
K
E
L
T
D
I
F
R
H
I
D
K
N
G
D
G
Q
L
D
R
Q
E
L
--------------
I
D
G
Y
S
K
L
S
G
---------
E
E
V
A
VF--
P
-------
Q
------------
I
E
S
E
V
D
A
I
L
G
A
A
D
F
D
R
N
G
Y
I
D
Y
S
E
F
V
T
V
A
M
D
R
K
S
L
L
--------------------
S
K
D
K
L
E
S
A
F
Q
K
F
D
Q
D
G
N
G
K
I
S
V
D
E
L
A
S
V
F
L-
D
H
L
E
S
K
T
W
K
E
M
I
S
G
I
D
S
N
N
--
D
G
D
V
D
F
E
E
F
C
K
M
I
Q
K
L
-------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.87
38%
-147
- C1 -
-
2YZA
-
AAPK2_HUMAN
A:
[14-278]
-----------------------------
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
---
A
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
-
M
M
S
D
-----------------
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
-
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
----
I
---
P
---
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
-----
D
L
P
S
Y
L
F
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
63.17
30%
-35
- C1 -
-
3MWU
1
?
A:
[29-424]
------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
K
D
T
-
S
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
---
S
K
---
E
---
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
----
D
R
-------
I
G
T
A
Y
Y
I
A
P
E
V
L
--
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
-
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
FDL
P
Q
---
W
---
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
--
I
-----
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
-----
L
----
E
---
S
----
A
M
----
T
-
N
-
I
R
Q
F
Q
A
E
--
K
K
L
A
Q
A
--
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
GVD
S
N
S
L
I
Q
-
N
E
---------
G
------
S
T
-------
I
-------------
E
D
Q
I
D
S
L
M
P
L
L
D
M
D
G
S
G
S
I
E
Y
S
E
F
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
62.17
38%
-144
- C1 -
-
3AQV
1
AAPK2_HUMAN
A:
[11-276]
-----------------------------
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
---
A
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
-
M
M
S
D
G
E
F
------
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
-
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
----
I
---
P
---
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
-----
D
L
P
S
Y
L
F
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
61.84
30%
-42
- C1 -
-
3NCG
1
?
A:
[29-435]
------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
K
D
T
-
S
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
---
S
K
---
E
---
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
------------
I
G
T
A
Y
Y
I
A
P
E
V
L
--
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
-
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
FDL
P
Q
---
W
---
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
--
I
-----
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
-----
L
----
E
---
S
----
A
M
----
T
-
N
-
I
R
Q
F
Q
A
E
--
K
K
L
A
Q
A
--
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
GVD
S
N
----------------
G
------
S
T
-------
I
-------------
E
D
Q
I
D
S
L
M
P
L
L
D
M
D
G
S
G
S
I
E
Y
S
E
F
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
60.62
30%
-42
- C1 -
-
4Y5Q
1
?
A:
[29-419]
------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
K
D
T
-
S
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
---
S
K
---
E
---
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
---
D
R
-------
I
G
T
A
Y
Y
I
A
P
E
V
L
--
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
-
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
FDL
P
Q
---
W
---
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
--
I
-----
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
-----
L
----
E
---
S
----
A
M
----
T
-
N
-
I
R
Q
F
Q
A
E
--
K
K
L
A
Q
A
--
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
GVD
S
N
S
---------------
G
------
S
T
-------
I
-------------
E
D
Q
I
D
S
L
M
P
L
L
D
M
D
G
S
G
S
I
E
Y
S
E
F
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
60.11
28%
-18
- C1 -
-
4MVF
2
CDPK2_PLAFK
A:
[52-501]
------------------------
S
G
K
L
E
D
K
Y
I
I
D
E
K
L
G
Q
G
T
Y
G
C
V
Y
K
G
I
D
K
V
T
N
Q
L
Y
A
I
K
E
E
K
K
D
R
L
K
--
N
I
N
-
R
F
F
Q
E
I
E
I
M
K
K
L
D
H
P
N
I
V
K
L
Y
E
T
Y
E
N
D
N
Y
I
Y
L
I
M
E
L
C
S
G
R
E
L
F
D
S
I
I
E
N
G
S
F
T
E
K
N
A
A
T
I
M
K
Q
I
F
S
A
I
F
Y
L
H
S
L
N
I
V
H
R
D
L
K
P
E
N
F
L
F
Q
---
S
E
NKD
S
---
L
---
L
K
I
I
D
F
G
L
S
K
-
N
L
------------------------------
K
-
Y
D
K
K
C
D
I
W
S
S
G
V
I
M
Y
T
L
L
C
G
Y
P
P
F
Y
-----------------
C
---
F
Y
END
W
---
G
S
I
S
S
D
A
K
N
L
I
T
K
L
L
T
Y
N
P
N
E
R
C
T
I
E
E
A
L
N
H
P
W
I
T
Q
-----
M
T
K
S
--
H
V
E
--
L
S
S
T
-----
L
----
L
---
K
----
N
L
K
N
FK
K
-
E
-
N
E
L
K
K
-
I
--
A
L
T
---------
I
I
A
K
H
L
C
D
V
E
I
N
N
L
R
N
I
F
I
A
L
D
V
D
N
S
G
T
L
S
S
Q
E
I
--------------
L
D
G
L
K
K
I
G
-----------------
Y
Q
-------
K
------------
I
P
P
D
I
H
Q
V
L
R
D
I
D
S
N
A
S
G
Q
I
H
Y
T
D
F
L
A
A
T
I
D
K
Q
T
Y
L
--------------------
K
K
E
V
C
L
I
P
F
K
F
F
D
I
D
G
N
G
K
I
S
V
E
E
L
K
R
I
F
--
G
P
L
I
D
K
A
I
D
S
L
L
Q
E
V
D
L
N
G
--
D
G
E
I
D
F
H
E
F
M
L
M
M
S
K
L
E
H
-----------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
59.05
38%
-109
- C1 -
-
4D28
-
CIPKO_ARATH
A:
[9-270]
-----------------------------
G
K
Y
E
V
G
R
T
I
-----
A
K
V
K
F
A
R
N
T
D
T
G
D
N
V
A
I
K
I
M
A
K
S
T
I
L
K
N
R
M
V
D
Q
I
K
R
E
I
S
I
M
K
I
V
R
H
P
N
I
V
R
L
Y
E
V
L
A
S
K
S
K
I
Y
I
V
L
E
F
V
T
G
G
E
L
F
D
R
I
V
H
K
G
R
L
K
E
D
E
S
R
K
Y
F
Q
Q
L
V
D
A
V
A
H
C
H
S
K
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
---
T
N
---
G
---
N
---
L
K
V
S
D
F
G
L
S
A
-
L
P
Q
E
G
--------
L
N
D
T
C
G
T
P
N
Y
V
A
P
E
V
L
S
G
Q
G
Y
D
G
S
A
A
D
I
W
S
C
G
V
I
L
F
V
I
L
A
G
Y
L
P
F
S
E
T
D
L
P
G
L
Y
R
K
-
I
N
A
A
E
F
D
----
C
---
P
---
P
W
F
S
A
E
V
K
F
L
I
H
R
I
L
D
P
N
P
K
T
R
I
Q
I
Q
G
I
K
K
D
P
W
F
R
K
-----
N
Y
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
57.98
30%
-38
- C1 -
-
3IGO
8
?
A:
[29-417]
------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
K
-
T
-
S
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
---
S
K
---
E
---
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
--------------
T
A
Y
Y
I
A
P
E
V
L
--
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
-
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
FDL
P
Q
---
W
---
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
--
I
-----
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
-----
L
----
E
---
S
----
A
M
----
T
-
N
-
I
R
Q
F
Q
A
E
--
K
K
L
A
Q
A
--
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
GVD
S
N
S
L
I
Q
------------
G
------
S
T
-------
I
-------------
E
D
Q
I
D
S
L
M
P
L
L
D
M
D
G
S
G
S
I
E
Y
S
E
F
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
56.04
35%
-129
- C1 -
-
5ES1
1
MARK4_HUMAN
A:
[15-286]
-----------------------------
G
N
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
N
P
S
S
L
Q
K
L
F
-
R
E
V
R
I
M
K
G
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
S
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
L
L
D
---
A
E
---
A
---
N
---
I
K
I
A
D
F
G
F
S
N
--------------------
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
H
N
-
L
K
E
L
R
E
R
V
L
R
G
K
Y
----
R
V
---
P
---
F
Y
M
S
T
D
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
R
C
T
L
E
Q
I
M
K
D
K
W
I
N
I
GYEGE
E
L
K
P
Y
T
E
P
E
E
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------