@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_34_1950: (2018-03-12 )
MCEVLDALRSSSVGLLFLNHPEVSFSNRSCVICIPDFHQDETIDGYRLRAAYNAGTIGRSYFATRDVAALSSRCTPPHGSSDSLSDDAARGPVFRILKVISFVLRRRLLEEITAEQRVLVNIVHQNVLQISDVLNDEAKENMIVITNYHAKGNIGNYAGRLSHDSDKLRRILTEVAVGLRILHSHRVYHHNLKLDNVLENGEGHFCIADAGFWRLFAVQCPEDLVFNGELACLPPEVFDPEGPYATGEVNVVSDEGAAGVAAVDIWGFGVLMYRLAYGCDPIEIAECSYAQVHERLMGFDLSFPPRPHWSFAYDIEDAIRLCLQKVPSKRPSVLRLLQHPFFKHSLVVGTSSLMRKMSMTSSFAFGGQMVGSFGDRTMSAPGLRGASMSSMAVPNYRTQQRNGFQVDAFLGEGRFSETMMVHLRRNHSKQFAFKIIYKSILKRLQAPGREKWAREMRRQLVFSRKVDHPNVMRFIDIVEDKKVNCFVVQDYMSGGSIEAVPPVKGDSSSPTLQDFLVDVLAGLVHLHDNGVAHLSLLPTNIFFCEHTLHYCIADFGPLFVTADALADSIAEGAPLYALPAWVRRHSPLHGPSVDMFCVGLLAASVLPELFDTVWAELLDSEKNRTFAVDAVLTAVRKQRAQLTPALVSFIEDALEGRFQDARAALKHTYFGNLSFAQNLPKTIVEVTEEELQSAVHSKPETRDEARMLEVLAQDPFQESQMLSSAGDATLHGSESCTEASVIAGATGEKPTVLVFEGENLLCGQCSAELTVALYQCSDCDGYIRCGKCSVGNYHKDGHELVPFLIHTIEHSRDGANKAVLVQPSTVPDVHALETLEMTANFPVGSLTAHLVAQRAAERSIAVRSTGGGSITKGMFGDMESVVRLPDDISEQSISVNINCRSFISFRGLGGMPGGGLNLGSGANNSNTGFNTVGFPHGRADPVTPKDFGSLCLPPPTRLSLMKGKEARKLVLPKAEEIEDDDWQQELERCRTSNHSELLLYNYGLDEVPPEVYDPPLLQVVVLDISQNNLRSLPHELSFLIHLRKLVVSYNKLTELPDSLGNLSELESLDASHNALVDLPQTFIYLSSLTSAALDYNNFSSIPDSLLDIVAPPLCSSASNVMENFAMSTTQVNGARMASLVGNTAVSLVGGSSVSNSKTVIMSPKLKVIYLAANDSLTTLPLRERLQRFDDLTIALDNEPSLYKDYYEKNLDTELPNITVNWNKLYPDEIVPYLYCGSLRSAQSQMVYRKLNITYLLTVGRQLVPVPPEGGHHKVIVVDDIPGANIRMSFQEAVNFIEESQSKKSGCLVHCFAGLSRSATTVIAYLMIKRGMRLDEAYLVTKKGRPAILPNKGFFDQLVELDKELYPKPNRPLDIESLGRSAN
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80......-------------------------------..90......----..100..-----------------.....110.......120.-.......130.......140.......150.......160-----..-......170.......180.......190.......200---.----.--.....210.......220.......230.......240.......250.......260.......270.......280......-.290.......300.......----310.......320.......330.......340.......350.......360.......370.......380.......390.......400-.........410.......420.......430.......440.......450.......460.......470.......480..-.....490.......500.....---..510.......520.......530.......540....---...550.......560.......570.......580..----.....590.......600....-----------.--..610.......620.......630-----..--.......640.......650....-...---660.......670.......680.----------......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270--........1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
C
E
V
L
D
A
L
R
SSS
V
G
L
L
F
LNHPEVSFSNR
S
C
V
I
CIPDFHQDETID
G
Y
R
L
R
A
A
YNAGTIGR
S
Y
FA
T
R
D
V
A
A
L
SSRCTPPHGSSDSLSDD-------------------------------AAR
G
P
V
F
R
I
L
----
K
V
I
S
F
V
L
-----------------
R
R
R
L
L
E
E
I
T
A
E
Q
R
V
L
V
-
N
I
-
V
H
Q
N
V
L
Q
I
S
D
V
LNDEAKE
N
M
I
V
I
T
NYHAKGNIGNYAGR-L-----SH-
D
S
D
K
L
R
R
I
L
T
E
V
A
V
G
L
R
I
L
H
SH
R
V
Y
H
HNLK
L
D
N
VLENGE---G----
H
--
F
C
I
ADAG
F
W
R
L
F
A
VQCPE
D
L
VFNGELACLPPEVFDPEGPYATG
E
V
N
V
VSDEGAA
G
V
A
A
V
D
I
W
G
F
G
V
L
M
Y
R
L
AYGCDP
I
E
IAEC
S
-
Y
A
Q
V
H
E
R
L
MGFDLSFPPRPH
W
----
S
F
A
Y
D
I
E
D
A
I
R
L
C
L
Q
KVPSK
R
P
S
V
L
R
L
L
QHPFFK
H
S
L
V
V
G
T
S
S
L
M
R
K
M
S
MTSSFAFG
G
Q
M
V
G
SFGDRTMSAPGLRGASMSSMAVPNYRTQQ---RN
G
F
Q
V
D
A
F
LGEGRF
S
E
T
M
M
V
H
L
RRNH
S
K
Q
F
A
F
K
I
I
Y
K
S
I
L
K
R
LQAP
G
R
E
K
W
A
R
E
M
R
R
Q
L
V
F
SRKVD
H
P
N
V
M
R
F
I
D
I
VEDKK
V
N
-
C
F
V
V
Q
D
YMSGGS
I
E
AVPPVKGDS---SSP
T
L
Q
D
F
L
V
D
V
L
A
G
L
V
H
LHDNG
V
A
H
L
S
LLPT
N
I
F
F
C
E
H
---
T
L
H
Y
C
I
ADFG
P
L
F
V
T
A
D
A
L
A
D
S
I
AEGAP
L
Y
A
L
P
A
W
V
R
R----HSPLHGP
S
V
D
M
F
C
V
G
L
L
A
A
S
V
L
-----------
P
--
E
L
F
D
T
V
W
A
E
L
L
DSEKN
R
T
F
A
V
D
A
-------
V
L
--
T
A
V
R
K
Q
R
AQL
T
P
A
L
V
S
F
I
E
D
A
L
E
G
-
R
F
Q
---
D
A
R
A
A
L
K
H
T
YFGN
L
S
F
A
Q
NL
P
K
T
I
----------
V
E
V
T
E
E
E
L
Q
S
A
VHSKPE
T
R
D
E
A
R
M
L
E
V
L
A
QDP
F
Q
E
S
Q
M
L
SSAG
D
A
T
LHGSESCTE
A
S
V
I
AGATGEK
P
T
V
L
V
F
EGENLLCGQCSA
E
L
T
V
A
L
Y
QCSDCD
G
Y
I
R
CGKCSVGNYHKD
G
H
E
L
V
P
F
L
I
H
T
I
EHSRDGAN
K
A
V
L
VQPSTVPD
V
H
A
L
E
T
L
E
M
TANFP
V
G
S
L
T
A
H
L
V
A
Q
R
AAE
R
S
I
A
V
R
STGGGSI
T
K
G
M
FG
D
M
E
S
V
V
RLPDDISE
Q
S
I
S
V
N
I
N
C
R
S
F
I
SFRGLGGMPGGGLNLGSGANNSNTGFNTVGFPHGRADPV
T
P
K
DFGSLCLPPP
T
R
L
S
L
MKGKEA
R
K
LVLP
K
A
E
EIED
D
D
W
Q
Q
E
L
E
R
C
RTSNH
S
E
L
L
L
Y
NYGLDEVPPEVYDPP
L
L
Q
V
V
V
L
DISQ
N
N
L
R
S
L
P
H
E
L
S
F
L
I
H
L
R
K
L
V
V
S
Y
N
K
L
T
E
L
P
D
SLG
N
L
S
E
L
E
S
LDASH
N
A
L
V
D
L
P
Q
T
F
I
Y
L
S
S
L
T
S
A
A
LDYN
N
F
SSI
P
D
S
L
L
D
IVAPPLC
S
S
A
S
N
V
M
E
N
FAMSTTQVN
G
A
R
M
A
S
L
VGN
T
A
V
S
L
VGGSSVSNS
K
T
V
I
MSPK
L
K
V
I
Y
L
AANDSLT
T
L
P
L
R
E
R
L
Q
R
FD
D
L
T
I
A
LDNEP
S
L
Y
K
D
Y
Y
E
KNLDTELP
N
I
T
V
NWNKL
Y
P
D
E
I
V
P
Y
L
YCG
S
L
R
S
A
Q
S
Q
M
V
Y
R
KL
N
I
T
Y
L
L
TVG
R
Q
LVPVPPEGG--
H
--
H
K
V
I
V
V
DDIPGAN
I
R
M
S
F
Q
E
A
V
N
F
I
E
E
SQSKKS
G
C
L
V
H
CFAGLSR
S
A
T
T
V
I
A
Y
L
M
I
K
RGMRLD
E
A
Y
L
V
TKKGRPAILPNK
G
F
F
D
Q
L
V
E
L
D
K
E
LYPKPNRPL
D
I
E
S
LGRSAN
47
Fugue
67.20
16%
-31
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
-
E
F
C
A
-
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
T
----
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
-----
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
PVT
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
-
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
-----
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
-
V
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
-
C
L
V
L
-
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
Q
A
G
F
-
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
-
D
D
---
H
G
H
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
Q
T
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
N
----
E
R
Y
--
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
-----------
A
GQ
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
-------
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
G
---
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
EPPFKPDPQA
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
57.59
24%
-29
- C1 -
-
5UY6
1
KKCC2_HUMAN
A:
[4-290]
------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
L
A
Y
N
E
N
D
------------------------------------------------------
N
T
Y
Y
A
M
----
K
V
L
S
K
K
K
L
I
R
Q
A
GFPRRPPPGCIQ
P
R
G
P
I
E
Q
V
Y
Q
E
I
A
I
L
K
-
K
L
-
D
H
P
N
V
V
K
L
V
E
V
L
D
D
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
M
E
V
P
T
L
-
K
-----
P
L
-
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
G
E
D
---
G
----
H
--
I
K
I
A
D
F
G
V
S
N
E
F
K
G
S
D
A
L
L
S
N
T
V
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
-------------
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
M
D
E
R
I
M
---
C
L
H
S
K
I
K
S
Q
A
L
E
F
P
--
D
Q
P
----
D
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
V
V
P
E
I
K
L
H
P
W
V
T
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
57.14
38%
-152
- C2 -
-
2G6Z
-
DUS5_HUMAN
A:
[6-147]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
E
I
L
P
F
L
Y
L
G
S
A
Y
H
A
S
K
C
E
F
L
A
N
L
H
I
T
A
L
L
N
V
S
R
R
T
S
E
A
C
M
T
H
L
--
H
--
Y
K
W
I
P
V
E
D
S
H
T
A
D
I
S
S
H
F
Q
E
A
I
D
F
I
D
C
V
R
E
K
G
G
K
V
L
V
H
S
E
A
G
I
S
R
S
P
T
I
C
M
A
Y
L
M
K
T
K
Q
F
R
L
K
E
A
F
D
Y
I
K
Q
R
R
S
M
V
S
P
N
F
G
F
M
G
Q
L
L
Q
Y
E
S
E
I
L
P
S
---------------
26
HHSearch
51.64
17%
-117
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-351]
------------------------------------------
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
------------------------------------------------------
S
G
K
L
V
A
V
----
K
K
M
D
L
R
K
------------------
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
-
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
--
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
-
T
-----
R
M
-
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
----
R
--
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
----------------
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
---
K
A
M
K
M
I
R
D
N
L
P
P
-
R
L
K
N
L
H
----
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
51.19
36%
-162
- C2 -
-
1WRM
1
DUS22_HUMAN
A:
[8-142]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
L
P
G
L
Y
I
G
N
F
K
D
A
R
D
A
E
Q
L
S
K
N
K
V
T
H
I
L
S
V
H
D
S
A
R
P
M
L
-
E
G
V
--
K
--
Y
L
C
I
P
A
A
D
S
P
S
Q
N
L
T
R
H
F
K
E
S
I
K
F
I
H
E
C
R
L
R
G
E
S
C
L
V
H
C
L
A
G
V
S
R
S
V
T
L
V
I
A
Y
I
M
T
V
T
D
F
G
W
E
D
A
L
H
T
V
R
A
G
R
S
C
A
N
P
N
V
G
F
Q
R
Q
L
Q
E
F
E
K
--------------------
23
HHSearch
50.84
17%
-47
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[22-294]
-----------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
------------------------------------------------------
T
G
Q
Q
F
A
V
----
K
I
V
D
V
A
K
F
T
S
S-------------
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
-
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
--
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
-
R
A
D
A
G
F
V
Y
-
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
ENS
A
----
P
--
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
----------------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
----
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
----
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
50.27
20%
-88
* C1 *
-
5K00
1
MELK_HUMAN
A:
[6-266]
-----------------------------------------
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
------------------------------------------------------
T
G
E
M
V
A
I
----
K
I
M
D
K
N
T
-----------------
L
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
-
N
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
--
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
-----
R
L
-
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
---
H
----
K
--
L
K
L
I
D
F
G
L
C
A
K
P
------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
---------------
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
---
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
----
P
K
----
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
50.02
17%
-45
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[22-294]
-----------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
------------------------------------------------------
T
G
Q
Q
F
A
V
----
K
I
V
D
V
A
K
F
T
S
S-------------
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
-
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
--
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
-
R
A
D
A
G
F
V
Y
-
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
ENS
A
----
P
--
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
----------------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
----
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
----
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
49.92
39%
-102
- C2 -
-
3EZZ
-
DUS4_HUMAN
A:
[4-142]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
E
I
L
P
F
L
Y
L
G
S
A
Y
H
A
A
R
R
D
M
L
D
A
L
G
I
T
A
L
L
N
V
S
S
D
-
C
P
N
H
F
E
G
H
--
Y
Q
-
Y
K
C
I
P
V
E
D
N
H
K
A
D
I
S
S
W
F
M
E
A
I
E
Y
I
D
A
V
K
D
C
R
G
R
V
L
V
H
S
Q
A
G
I
S
R
S
A
T
I
C
L
A
Y
L
M
M
K
K
R
V
R
L
E
E
A
F
E
F
V
K
Q
R
R
S
I
I
S
P
N
F
S
F
M
G
Q
L
L
Q
F
E
S
Q
V
------------------
25
HHSearch
49.72
21%
0
- C- -
-
4PDP
-
?
B:
[194-472]
-----------------------------------------
F
K
D
F
S
I
I
D
E
V
V
G
Q
---
A
T
V
K
K
A
I
E
R
T
T
------------------------------------------------------
G
K
T
F
S
V
----
K
I
I
S
K
------------------------
D
G
V
T
R
E
L
E
V
L
Q
-
K
L
-
N
H
P
R
I
V
R
L
K
G
F
Y
E
D
----
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
-
H
G----
A
V
-
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
E
Q
D
---
D
----
P
V
L
V
K
I
T
A
F
G
L
A
K
V
Q
------------
T
L
A
Y
V
A
P
E
V
I
------------------
N
E
Y
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
G
S
T
Q
---
D
Q
L
Y
K
Q
I
G
R
G
S
Y
H
E
G
P
L
K
D
F
----
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
T
A
A
K
A
L
N
H
P
W
I
K
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
49.59
34%
-156
- C2 -
-
4WOH
3
DUS22_HUMAN
A:
[9-143]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
L
P
G
L
Y
I
G
N
F
K
D
A
R
D
A
A
Q
L
S
A
N
A
V
T
H
I
L
S
V
H
D
S
A
R
P
M
L
-
E
G
V
--
K
--
Y
L
C
I
P
A
A
D
S
P
S
Q
N
L
T
R
H
F
K
E
S
I
K
F
I
H
E
C
R
L
R
G
E
S
C
L
V
H
S
L
A
G
V
S
R
S
V
T
L
V
I
A
Y
I
M
T
V
T
D
F
G
W
E
D
A
L
H
T
V
R
A
G
R
S
C
A
N
P
N
V
G
F
Q
R
Q
L
Q
E
F
E
K
--------------------
19
PsiBlast_PDB
49.04
35%
-181
- C2 -
-
3S4E
-
DUS19_HUMAN
A:
[7-135]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
P
W
L
L
L
G
S
Q
D
A
A
H
D
L
D
T
L
K
K
N
K
V
T
H
I
L
N
V
A
Y
G
V
E
N
A
F
L
S
D
F
--
T
--
Y
K
S
I
S
I
L
D
L
P
E
T
N
I
L
S
Y
F
P
E
C
F
E
F
I
E
E
A
K
R
K
D
G
V
V
L
V
H
S
N
A
G
V
S
R
A
A
A
I
V
I
G
F
L
M
N
S
E
Q
T
S
F
T
S
A
F
S
L
V
K
N
A
R
P
S
I
C
P
N
S
G
F
M
E
Q
L
-------------------------
45
Fugue
47.66
22%
-32
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
-----------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
LTEK
L
K
P
V
DY
E
Y
R
E
EVH
W
A
T
H
Q
LRLGR
G
S
F
G
E
V
H
R
M
E
D
KQT
G
F
Q
C
A
V
K
-----------------
K
V
R
L
E
V
F
R
A
E
E
L
M
A
C
A
-
G
L
-
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
--
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
-
Q
-----
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
---
G
S---
H
--
A
A
L
C
D
F
G
H
--------
A
V
C
L
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
----------------
L
G
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
--------
W
T
Q
F
F
R
G
P
L
C
L
K
I
A
S
E
P
P
P
V
R
EIPP
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
47.52
23%
-5
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[9-278]
-----------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
------------------------------------------------------
G
L
Q
Y
A
A
----
K
F
I
K
K
R
R
TKSSR------------
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
-
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
--
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
-
K
E----
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
---
N
VP
K
P
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
-
P
---------------
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
---
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
----
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
47.05
35%
-178
- C2 -
-
4D3P
-
DUS19_HUMAN
A:
[11-139]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
P
W
L
L
L
G
S
Q
D
A
A
H
D
L
D
T
L
K
K
N
K
V
T
H
I
L
N
V
A
Y
G
V
E
N
A
F
L
S
D
F
--
T
--
Y
K
S
I
S
I
L
D
L
P
E
T
N
I
L
S
Y
F
P
E
C
F
E
F
I
E
E
A
K
R
K
D
G
V
V
L
V
H
A
N
A
G
V
S
R
A
A
A
I
V
I
G
F
L
M
N
S
E
Q
T
S
F
T
S
A
F
S
L
V
K
N
A
R
P
S
I
C
P
N
S
G
F
M
E
Q
L
-------------------------
51
Fugue
46.78
15%
-26
- C1 -
-
4EUT
1
TBK1_HUMAN
A:
[2-387]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
Q
S
T
S
---
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
---------
L
F
A
I
K
V
F
N
N
I
S
F
L
R
P
V
D
V
Q
M
R
E
F
E
V
L
K
K
L
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
YGL
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
EDG
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
Q
F
V
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
VLD
H
Q
K
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
TGSLPFRPFEG
P
--
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
KAEN
G
P
I
D
W
--
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
-
I
L
E
ADQ
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
----------
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
--
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
46.40
40%
-68
* C2 *
-
2OUD
-
A:
[11-148]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
P
F
L
F
L
G
N
E
Q
D
A
Q
D
L
D
T
M
Q
R
L
N
I
G
Y
V
I
N
V
T
T
H
L
P
L
Y
H
Y
E
K
G
L
F
N
--
Y
K
R
L
P
A
T
D
S
N
K
Q
N
L
R
Q
Y
F
E
E
A
F
E
F
I
E
E
A
H
Q
C
G
K
G
L
L
I
H
C
Q
A
G
V
S
R
S
A
T
I
V
I
A
Y
L
M
K
H
T
R
M
T
M
T
D
A
Y
K
F
V
K
G
K
R
P
I
I
S
P
N
L
N
F
M
G
Q
L
L
E
F
E
E
D
L
------------------
34
HHSearch
46.13
20%
-24
- C1 -
-
4NIF
-
KS6A1_HUMAN
A:
[7-270]
------------------------------------------
S
D
G
Y
V
V
K
E
T
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
K
A
T
-----------------------------------------------------
N
-
M
E
Y
A
V
----
K
V
I
D
K
S
K
----------------------
R
D
P
S
E
E
I
E
I
L
L
R
Y
G
-
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
--
K
H
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
L
R
-
Q
K----
F
F
-
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
---
S
GNPE
C
--
L
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
N
G
L
L
M
T
P
C
Y
---
F
V
A
P
E
V
L
K
R
Q
----------------
G
Y
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
F
A
N
G
P
S
D
T
P
E
E
I
L
T
R
I
G
S
G
K
F
T
L
S
G
G
N
W
N
----
T
V
S
E
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
K
Q
V
L
Q
H
P
W
V
T
Q
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
46.09
19%
-33
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[92-364]
-----------------------------------------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
------------------------------------------------------
G
H
E
F
A
V
----
K
I
M
E
V
T
A
ERLSPEQ----------
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
-
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
--
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
-
K
V----
A
L
-
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
---
M
----
Q
--
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
-
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
----------
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
---
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
----
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
45.95
38%
-61
- C2 -
-
4Y2E
-
DUS7_HUMAN
A:
[5-146]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
V
Q
I
L
P
Y
L
Y
L
G
C
A
K
D
S
T
N
L
D
V
L
G
K
Y
G
I
K
Y
I
L
N
V
T
P
N
L
P
N
A
F
E
H
G
G
--
E
F
T
Y
K
Q
I
P
I
S
D
H
W
S
Q
N
L
S
Q
F
F
P
E
A
I
S
F
I
D
E
A
R
S
K
K
C
G
V
L
V
H
S
L
A
G
I
S
R
S
V
T
V
T
V
A
Y
L
M
Q
K
M
N
L
S
L
N
D
A
Y
D
F
V
K
R
K
K
S
N
I
S
P
N
F
N
F
M
G
Q
L
L
D
F
E
R
T
L
------------------