@TOME V2.3
(Mar 2018)
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Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_34_4160: (2018-03-12 )
MSSVDSDKLATSIRALAGSRDERIAFVTEGVKQAKELQGKSVQEYEMVVSSLLMCLESFEVVHGTSLDVLCELTVLDILLNLDLSVIQLSQCNSYLRLCLMAVNEIPVAVAAAKTFAQTLSYSMTTDFVRTQIGETLEWISLSDAKSQPRRICGILVLTEVALRIPMVILPRLSEVFDRAWDCLVVHDEEVRSRALCLFTLCAKLLVNRPAAIRAETCDALMSHLKGNLASKSKGKRIAGLLAFEPIVINSIGTSNIRYEDLSNLLVPYIMGGGANVNADTRELLFRCLVVLCRFSAPQFVAHQLKESVRFALDSINRNIQRNTAFEMLSEIIPIVGKTEFAPFVDDTCEVIKTIFEKSPSPCWKALQCFSIICKECRPSKMETYVESCIENVFVWGLSAELIECMRAIIESSSVQYRAKLEESLLDMISVTLCGLPFRQQIDAPRVSESSTDVSASEYQISVALNALKQFGFSNSELMGDFLRVSVLPFIDNNSVAVRNAAVYTIVKLLIPPGEKGDLSIARRMCVNTVITRMLVVGLSDPNPVVRQTILSAFTEDFYPYLSEQQYLFRFYSALGDESINCRVAATEQLCQMIRYDPSHILPALREEMVVILHFITSTFNMDTVQNGFRLLAAIATRAPQLVVNFTEGICEALAPYFSTLSSRSGILLSFLHCCTAVAAALRKFGSTPFSSKREIALVCELLETLPADRSYHIIRLSCLRFLSATLAPLMEGASPYVLYPRLFQQLCTVLHRTEESVDIRLEALRCIGVIGALDSHVFQSFNLNEKEKASGMSAVVVDRVTHVKCCRIVLCAVAALLDPESKRSAGAREGLLRTGVQTMLNIFEHVPCSKSEIGLVIGPLARVIRQLPGGRLFATVLFEFCNIIRYGGAVVLNDLNEIYRVFDNVWEFQVNYRFLAVRMLSFVANFEASGNLHYGQQHSRILPQLFDTLNRADLRADLKYAVLEYIVRHVDSLQPCTEAAVDNLLGAIQNPANPLDFVNHCVVTLKEICVKLYVDELVGAIVRCLLACLSVDLARKTRGRDNIALCNNIMGVFCVLIEELQGNFLKYSTYIIQALKNYRITNTEFGVMNNRVATGLRCARSAMSIQQQNAEVAALLKTCESVVMKSMSRMGEVWSYANLNDDNANAGAAEERTMPINEQRLINPMKVVPLTKEEWVKWSDQFAITLLQESPFQVFRCTAVPIGINAAPLVEKSTQFVQDTLQIAFRSMWNYASSALQTAITDFFRQSFRQAMMSTTVPAEVVTMLLGIVEYMDHVGEALFISYNDLSECAWNRGMLAKALFWREAAYRDDPVGTVESLISLYSELHMVDSSVGILNMTSEEQRRSLLQTSLVKLARYTEALQLTQQELELEAAPLEESSTENLSKGCGYKNGSRGWSRMLHYTSNSDLTPSSSKAEESCRDRRVEVNARLMLCLSELGEYDKVLEQWGSMLHNYKDRVTDTDEMHVLFFVSQYAADASIRLQSWDTLEHVLDWLPPDMVLYHVSKAALEVVRGNYDAALVSVTNGRKVLLEDLTSLLHESYARAYEGLVVAQQLTEVEEVIIAKQTQKALSSAAHIPHLCHIWEQRIRMMHATVPTWKQVLGIRGLLISPHEDVKTRIQFTKLCRQEKARQLEKFTLAELLGFANPTLEQLTSRNVNPRVVMQYISYLSETNALGPGSAFGTESDLIKKMIDVHTKAENSAVLARAYTRLGSKVDLIESVQCFKTAIMYDPQWFLAWRKWAEANAQLLQTDKGEETCRNAIEGFIRSIQLGTSDSTLIQDVLKLLTLWSSHCDSDHNLKELRERVFDVPSRVWHLVVPQLVARLDTGSDDSCRLVADVLTNVGYDYPHTLVYPLNLCTMSDSERRNRYSNEVLGKLQERYPVIVLQGRLMIDELIRVSALIYEQWYDKLEAAATAFFGRRSTDEMIRTLLPIHETLTRVPETVVESEFLSKYSKRLTEARDWLRSYSSTRYTGDIQSAWKLYHSVYCNIDKQIKSSDTLQLQFCSPKLFEARNLSIGIPDARPVREESVAKVNRFQKDIIVIASKQRPKRIGIITAEGRLQKFLLKGREDLRLDERVMQLFSLVNILMQSDSRTSKNLGFQIQRYSVTPLKDNVGIIGWVDGCDTLHEVVKHFRERKSIPVELEMRMLDQIITFDNSKAYDYLTIMSKVEVLEFLSDHTSGQDIRKAMWNTSPNCEVWYDRRRMYTTSLANMSIVGYILGLGDRHPNNIMLQRASGLVVHIDFGDCFEVAMTRDKFPEKVPFRLTRMLRSALDVSGVDGAFRACSETAMCVLREGSHSVLALLEAFIQDPLISWRLINRHGQEPESSNDHKTIEQQVNIANMRNATSTAGAESMCDSVGKRDSGTFSVAKHLCGEEVDVVHQGVFIVKRLSSKLKGQDFISAGTEPLDPRTQVGQLIEEATDVTNVAQSWSGWYPFW
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170........180.......190.......200.......210.....-..220-------------........230.......240...--....250...----..-..260.......270.......280.......290..------.....300.......310......--.320.......330.......340.......350.......---360-.......370......--.380.......390.......400.......410.......420.......430.......-----------440.......-------450.......460.......470...-.....480.......490.......500....-----...510.......520.......530.......540.......---550.......560------..---.....570......-.580.......590.......600.......610.......620.......630.......640.--......650......------.660.......670.......680.....--..690.......700.......---------------710......-.720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......---820.......--830....-------...840......--.850.......860......---.-870.......880.......-------------890.......900.---......910...-......920.......930.......940.......950.......960.......970.......980.......990-.......1000......1010.......1020......1030......1040......1050......1060......1070......1080......1090......1100..--....1110......1120......1130......1140......1150......1160......1170.......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270...-...1280......1290...----...1300......1310.......1320......1330......1340......1350.-.....1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680........1690...----------..----------.1700......1710......1720-------........1730......1740---.......1750..-------------------..------------------..1760----------------.........1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......---2320......2330......2340......2350......2360......2370......2380......2390......2400......2410......2420......2430.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSSV
D
S
D
K
L
A
T
S
I
R
A
L
AGSRD
E
R
I
A
F
V
T
E
G
V
K
Q
A
K
E
LQGK
S
V
Q
E
Y
E
M
V
V
S
S
L
L
M
C
L
E
S
F
E
V
VHGT
S
L
D
V
L
C
E
L
T
V
L
D
I
L
L
NL
D
L
S
V
I
Q
L
S
Q
C
N
S
Y
L
R
L
C
L
M
A
V
NEIP
V
A
V
A
A
A
K
T
F
A
Q
T
L
S
Y
S
M
T
T
D
F
V
R
T
Q
IGE
T
L
E
W
I
SLSDAKS
Q
P
R
R
I
C
G
I
L
V
L
T
E
V
A
L
R
I
P
M
V
I
L
P
-
R
L
S
E
V
F
DRAW
D
C
L
V
V
H
D
E
E
V
R
S
R
A
L
C
L
F
T
L
C
A
K
L
L
VNRPA
A
I
R
A
E
T
-
C
D
A
L
--------------
M
S
H
L
K
G
NLASKSKGK
R
I
A
G
L
L
A
F
E
--
P
I
V
I
NSIGTS----NI-
R
Y
E
D
L
S
N
L
L
V
P
Y
IMGGGANVN
A
D
T
R
E
L
L
F
R
C
L
V
V
L
CR------FS
A
P
Q
F
V
A
H
Q
L
K
E
S
V
R
F
A
L
D
S
I
NR--NIQR
N
T
A
F
E
M
L
S
E
I
I
P
IVGKTEFA
P
F
V
D
D
T
C
E
V
I
K
T
I
F
EKS---P
S
P
-
C
W
K
A
L
Q
C
F
S
I
I
C
K
ECR--
P
S
K
M
E
T
Y
V
E
S
C
I
E
N
V
F
VWGL
S
A
E
L
I
E
C
M
R
A
I
I
ESSSV
Q
Y
R
A
K
L
E
E
S
L
L
D
M
I
S
V
T
LCGL
P
F
R
-----------QQIDAPRVSE-------SSTDVSAS
E
Y
Q
I
S
V
A
L
N
A
L
K
QF-GFS-
N
S
E
L
M
G
D
F
L
R
V
S
V
L
P
FIDNN
S
V
A
V
R
N
A
A
V
Y
T
I
-----
V
K
L
LIPPGEK
G
D
L
S
I
A
R
R
M
C
V
N
T
V
I
T
R
M
L
VVGLSDP
N
P
V
V
R
Q
T
---
I
L
S
A
F
T
E
D
F
Y
P
Y
L------SE---
Q
Q
Y
L
F
R
F
Y
S
A
LGDE-SI
N
C
R
V
A
A
T
E
Q
L
C
Q
M
IRY
D
P
S
H
I
L
P
A
L
R
E
E
M
V
V
I
L
H
F
I
T
STFN
M
D
T
V
Q
N
G
F
R
L
L
A
A
I
A
TRA
P
Q
L
V
--
V
N
F
T
E
G
I
C
E
A
L
A
P
Y
F
------
S
T
L
SSRS
G
I
L
L
S
F
L
H
C
C
T
A
V
A
A
A
L
R
KFGS--TPFSSK
R
E
I
A
L
V
C
E
L
L
E
TLPAD---------------R
S
Y
H
I
I
R
L
S
-
C
L
R
F
L
S
A
T
L
A
P
L
MEGAS
P
Y
V
L
Y
P
R
L
F
Q
Q
L
C
T
V
L
HRTEES
V
D
I
R
L
E
A
L
R
C
I
G
V
I
G
A
L
D
S
H
V
F
Q
SFNLN
E
K
E
K
ASGM
S
A
V
V
VDRV
T
H
V
K
C
C
R
I
V
L
C
A
V
A
A
LLD---PESKRSAG
A
R
--
E
G
L
L
R
T
G
-------
V
Q
T
M
L
N
I
F
E
HVP--CSKSEI
G
L
V
I
G
P
L
A
R
V
I
R
QL---P-G
G
R
L
F
A
T
V
L
F
E
F
C
N
I
I
RYG
G
-------------
A
V
V
L
N
D
L
N
E
I
Y
R
V
F
---
D
N
V
W
E
F
Q
--
V
N
Y
-
R
F
L
A
V
R
M
L
S
F
V
A
NFEASGNLHY
G
Q
Q
H
S
R
I
L
P
Q
L
F
D
T
L
N
R
A
D
L
R
A
D
L
K
Y
A
V
L
E
Y
I
V
R
H
V
D
SLQ
P
C
T
E
A
A
V
D
N
L
L
G
A
IQNP-A
N
P
L
D
F
V
N
H
C
V
V
T
L
K
E
I
C
-
V
K
L
Y
V
D
E
L
V
G
A
I
V
R
C
L
L
A
C
L
S
V
D
L
A
R
KTRGRD
N
I
A
L
C
N
N
I
M
G
V
F
C
V
L
I
E
E
LQGN
F
L
K
Y
S
T
Y
I
I
Q
A
L
K
NYRITNTEFGVMN
N
R
V
A
T
G
L
R
C
A
R
S
A
M
S
--
I
Q
Q
QN
A
E
V
A
A
L
L
K
T
C
E
S
V
V
M
K
S
M
S
R
M
G
E
V
W
S
YANLNDDNANAGAAEERTMPI
N
E
Q
RLINP
M
K
VVPL-
T
K
E
E
W
V
K
WSD
Q
F
A
I
T
LLQESP
F
Q
V
F
R
C
TAVPIGINA
A
P
L
V
E
K
S
T
Q
F
V
Q
D
T
L
Q
I
A
F
R
S
M
W
N
Y
A
S
S
A
L
Q
T
A
I
T
D
F
F
R
Q
S
F
R
Q
A
M
M
STT
V
P
A
E
V
V
T
M
L
L
G
I
V
E
Y
M
D
HV-G
E
A
L
F
I
SY
N
D
L
S
E
C
A
WNR
G
M
----
L
A
K
A
L
F
W
R
E
AAYRDDP-
V
G
T
V
E
S
L
I
S
L
Y
S
E
L
H
M
VDSSV
G
I
L
NMT
S
E
E
Q
R
R
S
L
L
Q
T
S
L
V
K
-
L
A
R
Y
T
E
A
L
Q
L
T
Q
Q
E
LELEAAPLEESSTEN
L
S
KGCGYKNGSR
G
W
S
R
M
L
H
YTSNSDLTPSSS
K
A
E
E
S
C
RDR
R
V
E
V
N
A
R
L
M
L
C
L
S
E
LG
E
Y
D
K
V
L
E
Q
W
G
S
M
L
H
N
Y
K
DRVTDTDE
M
H
V
L
F
F
V
S
Q
YAAD
A
S
I
R
LQ
S
W
D
T
L
E
H
V
L
D
WLP
P
D
M
V
L
Y
H
V
S
K
A
A
L
E
V
V
RGNY
D
A
A
L
V
S
VTNGR
K
V
L
L
E
D
L
T
S
L
L
H
E
S
Y
A
R
A
Y
E
G
L
V
V
A
Q
Q
L
T
E
V
E
E
V
I
I
A
K
Q
T
Q
K
A
L
S
SAAH
I
P
H
L
C
H
I
W
E
Q
R
I
R
M
M
HATV
P
T
W
K
Q
V
LGIR
G
L
L
ISP
H
E
D
V
K
T
R
I
Q
F
T
K
L
C
R
Q
E
K
A
R
Q
L
E
K
F
T
L
A
E
L
LGFAN
P
T
L
E
Q
L
T
SRNV
N
P
R
V
V
M
Q
Y
I
S
Y
L
SETNALGPGSA--FG
T
E
S
D
L
I
K
K
M
I
D
V
HT----------KA----------E
N
S
A
V
L
A
R
A
Y
T
R
LGS
K
V
D
L
I
E
S
V
---------
Q
C
F
K
T
A
IMYD
P
Q
W
F
L
A
W
R
K
W
A
----
E
AN
A
Q
L
LQTDK
G
E
-------------------
E
T
------------------
C
R
N
-------------------
A
I
E
G
F
I
R
S
IQLGTS
D
S
T
L
I
Q
D
V
L
K
L
L
T
L
W
S
SHCDSDH
N
L
K
E
L
R
E
R
V
F
D
V
P
S
R
V
W
H
L
V
V
P
Q
L
V
A
R
LDTGSD
D
S
C
R
L
V
A
D
V
L
T
NVGYDYP
H
T
L
V
Y
P
L
N
L
C
TMS
D
S
E
R
R
N
R
Y
S
N
E
V
L
G
K
L
Q
ERY
P
V
I
V
LQ
G
R
L
M
I
D
E
L
I
R
V
S
A
L
I
Y
E
Q
W
Y
D
K
L
E
A
A
A
T
A
F
FGRR
S
T
D
E
M
I
R
T
L
L
P
I
H
E
T
L
T
RV
P
E
T
V
V
E
S
E
F
L
S
K
Y
S
K
R
L
T
E
A
R
D
W
L
R
S
YSSTRYTG
D
I
Q
S
A
W
K
L
Y
H
S
V
Y
CN
I
D
K
QIKSSD
T
L
Q
L
Q
FCSPKLFEARNLSIGIPDARPV
R
E
E
S
V
A
K
V
N
R
FQK
D
I
I
V
I
ASKQRP
K
R
I
G
I
I
TAE
G
R
L
Q
K
F
L
L
KGREDL
R
L
D
E
R
V
M
Q
L
F
S
L
V
N
I
L
M
QSDSRTSKNL
G
F
Q
I
Q
R
Y
SVTPLKDNV
G
I
I
G
WVD
G
C
D
T
L
H
E
V
V
K
H
F
R
E
RKSIP
V
E
L
E
M
R
M
L
D
Q
I
I
TFDNSKA
Y
D
Y
L
T
I
M
S
K
V
E
V
L
E
F
L
S
DHTS
G
Q
D
I
R
K
A
MWNTSPNC
E
V
W
Y
DR
R
R
M
Y
T
TSLAN
M
S
I
V
G
Y
I
L
GLGDRHPN
N
I
M
L
Q
RAS
G
L
V
V
H
IDFG
D
C
F
E
V
A
M
T
RDKFPEKV
P
F
R
L
T
R
M
L
R
S
ALDVSGV
D
G
A
F
R
A
C
S
E
T
A
M
C
V
LREG
S
H
S
V
L
A
L
L
E
A
F
I
QDP
L
I
S
W
R
L
I
N
---RHGQEPESSND
H
K
T
I
E
Q
Q
V
N
I
A
NMRNATSTA
G
A
E
S
M
C
D
S
VGKRDS
G
T
F
S
V
A
K
H
L
CG
E
E
V
D
V
V
H
Q
G
V
F
I
V
K
R
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LKGQ
D
F
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SAGTEPLD
P
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T
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G
Q
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A
T
D
V
T
N
V
A
Q
SWSGWYPFW
2
PsiBlast_PDB
55.32
40%
-112
- C1 -
-
4JSP
1
B:
[509-1174]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
N
--
L
Q
D
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L
T
L
W
F
D
Y
G
H
W
P
D
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C
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TNT------------------------------------------------
A
L
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-----------
K
A
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R
V
R
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64
Fugue
55.14
28%
-6
- C1 -
-
5H64
-
MTOR_HUMAN
A:
[210-2549]
------------------
V
A
A
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--------------
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----------------------------------------------
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--
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L
L
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L
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W
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Y
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---
T
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A
--------------------------------------------------------
L
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A
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L
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C
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W
65
Fugue
55.05
26%
-13
- C1 -
-
5FVM
-
?
A:
[85-2469]
---------
N
V
K
A
F
D
L
I
F
T
K
L
N
Q
L
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R
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A
A
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L
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N
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-
N
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-
S
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G
V
L
A
V
D
T
L
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------
E
L
P
N
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L
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Y
L
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V
L
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A
A
T
T
L
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K
L
--
A
V
L
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F
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L
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L
L
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I
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S
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--------------
P
-
F
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L
------------------------
R
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L
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A
-
A
V
T
L
--------------
G
K
C
L
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S
L
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K
K
W
V
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L
F
N
G
C
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--
L
L
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R
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L
-
K
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--------
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-------
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C
D
L
F
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----------------
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---------------------
Y
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S
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H
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-------
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---
S
----------------
L
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A
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------------------------------
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---
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D
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V
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A
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---------------------
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---------
L
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-------------------------------------------------------
E
V
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M
R
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L
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A
L
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----------
V
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W
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Q
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-------------------
A
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---
L
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L
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L
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A
I
L
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A
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W
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---
P
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H
A
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N
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L
L
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K
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A
A
K
M
----------------
E
L
Q
Q
K
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A
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C
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Y
I
G
W
C
S
--
6
PsiBlast_PDB
54.95
40%
-114
- C1 -
-
4JT5
1
B:
[509-1174]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
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F
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S
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S
L
S
R
G
N
N
--
L
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L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
-
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
M
-----
A
P
D
Y
D
H
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
TNT------------------------------------------------
A
L
N
K
-----------
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
S
H
D
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
5
PsiBlast_PDB
54.88
40%
-110
- C1 -
-
4JSX
1
B:
[509-1174]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
R
H
N
A
A
N
K
I
L
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
T
S
L
E
L
Q
Y
V
S
P
K
L
L
M
C
R
D
L
E
L
A
V
P
G
T
Y
D
P
-
N
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
-
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
M
-----
A
P
D
Y
D
H
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
TNT------------------------------------------------
A
L
N
K
-----------
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
S
H
D
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
3
PsiBlast_PDB
54.65
40%
-111
- C1 -
-
4JSV
2
B:
[509-1174]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
R
H
N
A
A
N
K
I
L
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
T
S
L
E
L
Q
Y
V
S
P
K
L
L
M
C
R
D
L
E
L
A
V
P
G
T
Y
D
P
-
N
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
-
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
M
-----
A
P
D
Y
D
H
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
TNT------------------------------------------------
A
L
N
K
-----------
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
S
H
D
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
7
PsiBlast_PDB
54.52
40%
-112
- C1 -
-
4JT6
1
B:
[509-1174]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
R
H
N
A
A
N
K
I
L
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
T
S
L
E
L
Q
Y
V
S
P
K
L
L
M
C
R
D
L
E
L
A
V
P
G
T
Y
D
P
-
N
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
-
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
M
-----
A
P
D
Y
D
H
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
TNT------------------------------------------------
A
L
N
K
-----------
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
S
H
D
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
1
PsiBlast_PDB
53.48
40%
-102
- C1 -
-
5H64
-
MTOR_HUMAN
A:
[1884-2549]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
R
H
N
A
A
N
K
I
L
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
T
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L
E
L
Q
Y
V
S
P
K
L
L
M
C
R
D
L
E
L
A
V
P
G
T
Y
D
P
-
N
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
-
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
M
-----
A
P
D
Y
D
H
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
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R
L
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G
K
I
L
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D
F
G
D
C
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
T
N
T------------------------------------------------
A
L
N
K
-----------
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
S
H
D
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
9
PsiBlast_PDB
50.10
40%
-108
- C1 -
-
3JBZ
2
A:
[500-1165]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
R
H
N
A
A
N
K
I
L
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
R
V
A
--------------------------------------------------------------------------------------------------
T
S
L
E
L
Q
Y
V
S
P
K
L
L
M
C
R
D
L
E
L
A
V
P
G
T
Y
D
P
-
N
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
-
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
M
-----
A
P
D
Y
D
H
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
TNT------------------------------------------------
A
L
N
K
-----------
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
S
H
D
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
66
Fugue
44.36
36%
9
- C1 -
-
4JSP
1
MTOR_HUMAN
A:
[10-1174]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
A
K
C
R
A
----
Y
A
K
A
L
H
Y
K
E
L
E
F
Q
K
G
P
T
P
A
I
L
E
S
L
I
S
I
N
N
K
L
Q
Q
P
E
A
A
A
G
V
L
E
Y
A
M
K
H
F
G
E
L
E
I
Q
A
T
W
Y
E
K
L
H
E
W
E
D
A
L
V
A
Y
D
K
K
M
D
T
-------------------------------------------------
N
K
D
D
P
E
L
M
L
G
R
M
R
C
L
E
A
L
G
E
W
G
Q
L
H
Q
Q
C
C
E
K
W
T
L
V
N
D
--------
E
T
Q
A
K
M
A
R
M
A
A
A
A
A
W
G
L
G
Q
W
D
S
M
E
E
Y
T
C
M
I
P
R
D
T
H
D
G
A
F
Y
R
A
V
L
A
L
H
Q
D
L
F
S
L
A
Q
Q
C
I
D
K
A
R
D
L
L
D
A
E
L
T
A
M
A
G
E
S
Y
S
R
A
Y
G
A
M
V
S
C
H
M
L
S
E
L
E
E
V
I
Q
Y
K
L
V
P
E
------
R
R
E
I
I
R
Q
I
W
W
E
R
L
Q
G
C
Q
R
I
V
E
D
W
Q
K
I
L
M
V
R
S
L
V
V
S
P
H
E
D
M
R
T
W
L
K
Y
A
S
L
C
G
K
S
G
R
L
A
L
A
H
K
T
L
V
L
L
L
G
V
D
P
S
R
Q
L
D
H
P
L
P
T
V
H
P
Q
V
T
Y
A
Y
M
K
N
M
W
K
S
A
R
--
K
I
D
A
--
F
Q
H
M
Q
H
F
V
Q
T
M
Q
Q
Q
A
Q
HAIATED
Q
Q
H
K
Q
----------
E
L
H
K
L
M
A
R
C
F
L
K
L
G
E
W
Q
L
N
L
Q
G
I
NEST
I
P
K
V
L
Q
Y
Y
S
A
A
T
E
H
D
R
S
W
Y
K
A
W
H
A
W
A
----
V
M
N
F
E
A
V
L
H
Y
K
H
Q
-------------------
N
Q
------------------
A
R
D
E
KK
K
V
T
E
D
L
S
K
T
L
L
M
Y
T
V
P
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
R
H
N
A
A
N
K
I
L
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
T
S
L
E
L
Q
Y
V
S
P
K
L
L
M
C
R
D
L
E
L
A
V
P
G
T
Y
D
-
P
N
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
-
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
M
-----
A
P
D
Y
D
H
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
---
T
N
T
A
--------------------------------------------------------
L
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
--
S
H
D
D
T
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
18
PsiBlast_PDB
43.36
36%
-165
- C1 -
-
4DRJ
1
B:
[9-98]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
42.75
36%
-163
- C1 -
-
4DRI
1
B:
[9-96]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
42.57
36%
-167
- C1 -
-
4DRH
1
MTOR_HUMAN
B:
[9-96]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
41.80
39%
-173
- C1 -
-
1AUE
-
MTOR_HUMAN
A:
[2023-2114]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Fugue
41.69
35%
-162
* C1 *
-
1NSG
1
B:
[1-94]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
41.62
35%
-164
- C1 -
-
2FAP
1
B:
[1-93]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
41.62
35%
-164
- C1 -
-
1NSG
1
B:
[1-93]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
40.25
40%
-
- C1 -
-
4JSN
-
MTOR_HUMAN
B:
[1884-2549]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
R
H
N
A
A
N
K
I
L
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
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A
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W
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W
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M
-----
A
P
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D
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L
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L
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V
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R
L
M
D
TNT------------------------------------------------
A
L
N
K
-----------
K
A
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Q
I
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N
R
V
R
D
K
L
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G
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F
W
70
Fugue
38.51
16%
-44
- C2 -
-
3W3W
-
IMB3_YEAST
A:
[3-1077]
----------------------------------------------------------------------------------------------------------
A
L
P
E
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---
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--------------
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---
P
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-----------------------------
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-----
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---
A
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----
I
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---
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A
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R
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D
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----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
36.66
10%
-57
- C2 -
-
4FDD
-
TNPO1_HUMAN
A:
[24-808]
------------------------------------------------------------------------------------------------------
S
P
D
T
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-------
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-
W
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--------------
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---
F
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-----
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--------------
I
I
L
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-------
K
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--------------------------------------
S
D
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A
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---
K
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------------------------
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---
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L
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N
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A
-------
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A
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-------------
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---
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-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------