@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_35_3220: (2018-03-13 )
MAHLDSDAITPHSPRSQPRILAGHIGEEKDAIDRDGMQPGGDVGNGAASILRRRWMYDGGRKIAPFLSARHTHQESKEKVEIGGDSSTVVVRPNVIAATPRENRSPLDRAITPPSPLQLLPKTILPASVVASTSLARQHGVRGNVRPVDEASTYNDEQANPEEHSSPSCSIIASSSSGGGDFSLEADNDAQLSNAPCHAPLGRRLTQLELPFPQVTLSSLLQSNQSTSADGVDTSAGSQDTRLSSKRSTASRRCYVPGRASRLHSNTLVSEGGGGMLSALFSNTSRATTQASEVTTRAPNESLHGLDTSYMRASLLSLSSETESASEGTSLTPVQQHDESITYRSSLPPPPPPPPVRTRTFTLAEATENAAHAAAKHSSTRLTPSALMTPPLMAVEPRSRLPSFRTRNPLMQPRQLSDGHLGEHAVAPSQLHDEDAPAAAGTPRSCYRGPRSALLRGCADRRQSASRTPPIAVLVPLPPKSEELAPAPAPASTPATASPPPTQPLDSDTYAVNANSLASEMSFRYRARPSPRAQQLDPASVLEPRASLCVSPLHPSLSQVYVLTPRPQPPRSTPARSSPPRSGDPTLLEYVASLKPPRGSCSIRRALLSVGVALCAVPLCVAILLFGLHYWAVTLQEKSYAEALLHARMGTMLKVDLELLLSILLSIVVVGGGSGTVIYVVLYRLAIRHQVRAFALCVRLADTLLPLDVHHLAAEDSEGRQDIAMPIDAAAAAAQQADNGDSRAQWFSPFVARWHEEVSRLVKLLTCPIEVSQAEWRSFLFSERRSLALPNEGTNGSGDLPVTETTLADGPFHNSNNRRSLPFGVQASVPMTENEPWPPHEAQPGSRYQMSEAVFSRRPQHPVDVSKRQEAVTVVVCRLMAPAELLVEQRPLTQAQLKELQRLSNEFHQRLRTVPRTSCAAVTEVGVSEVVFSFNTFSPLPSLVASPAAVALAVVAQKALVEWSPTYRGTPVQWGIAVHRFDAYICPTRGMQGRLYVSFGTVEYDFARQLAELAALFDYGALCHAGFLADASCESQCLPVDYVMDLRQQAFLVYQLHDGDVDREQRLQMNSAIASMRNGEYKAAADALGMWRRKSGGCSGLPRTAAHLRYVAGFLERAARKRRLRVSEATVEAVTAPSFTCAVEGVAEWAAESLLTSYFRPPPVWEEEEAPRAPSPDLLRAPAILATSGGGSCGLRKRECGSSNVLVPFSPQPSRGAAGELATFFRSLMRRSYQARTRYVLSAEQREGQVGSRAMGEPPHQPREVLAAIEGDARPPSSLQRCYGLPSPGTESVSGERNVLEDGSAPLSPRDNVTGCSSSFHATRSVFEASTPTTTFPDVTCGDRKWAALALLTEPDQSTVTVTASRPRLFSNSWSLAESGVPEMPTLTPLTSGVLRSSQSDVRRQRHASILISAAKKEDDAAGPVAACASAKDNATLRSSRGRRDSGGCRSERPRGRHGSQFTTEVPTSDELSSRLLGHQCVSQLTDTTIARFPSEVSHESLSARSGSVRRRASASTAAASSVLPLFADSMVPFTVQDRTEARSEAETACEADLNQELSMMSVAQRSRSRRSHRATAQPSSVVCSCTRRIDTSSSNTVMVFQGFHPDGYLVVVKRADRRAAKQVAQLRNEVDLLRELHHRNVVNIVSAWKDDEAVYFAMEYACETLATVLQKFKVLLPGVVRFYAREVLNALVYLHRDCGIIHRDLSPNNVIITNTTDRSRVKLIDFGRSIMGPHFCSGSSGMSTTVPGNASLEFTEQHSSRNKVSVTDVPTSVVGTPLFMSPQACRGLAHPTSDIWSLGIIVHLCLTGTYPYPPETFTDPETFVANIGSGRLTPVIADTCEMTGEARSFIEQCLTLSHTERPSAAALLKHGFVER
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600..-....1610......1620......1630......1640......1650......1660-.--......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780.....-.-1790..-.....1800......1810......1820......1830......1840......1850......1860......1870...----------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAHLDSDAITPHSPRSQP
R
I
LAGHIGEEKDAIDRDGMQPGGDVG
N
G
A
A
S
I
L
R
R
R
W
MYDGGR
K
I
A
P
F
L
S
A
RHT
H
Q
ESKE
K
V
E
IGGD
S
S
T
V
V
V
RP
N
V
I
A
ATPRENRSPLDRAITPP
S
P
L
Q
L
L
P
K
TIL
P
A
S
V
V
A
S
T
S
L
A
R
QHGVRGNVRPVDEASTYNDEQANPEEHSSPS
C
S
I
I
A
SSSSGGG
D
F
S
L
EADNDAQLSNAPCHA
P
L
GR
R
L
T
QLELPF
P
Q
V
T
L
S
S
L
L
QSNQSTSADGVDTSAGSQDTRLSSKRSTASRRCYVPG
R
A
SRLHSN
T
L
VSEGG
G
G
M
L
S
A
L
FSNTSRATTQAS
E
V
TTRAPNESLHGL
D
T
S
Y
M
R
A
S
L
L
SLSSETESASEGTSLT
P
V
Q
QHDESITYRSSLPPPPPPPPV
R
T
R
T
F
T
L
A
EATE
N
A
A
H
A
AAKHSSTRLT
P
S
ALMTPP
L
M
AV
E
P
R
SRLPSFRTRNPLMQPRQLSDGHLGEHAVAPSQLHDEDAPAAAGT
P
R
S
C
YR
G
P
R
S
A
L
L
R
G
C
A
D
R
R
QSASRTP
P
I
A
V
L
V
PLPPKSEELAPAPAPASTPATASPPPTQPLDSDT
Y
A
V
N
A
N
S
L
A
S
E
M
S
F
R
YRARPSPRAQQL
D
P
A
S
V
L
E
P
R
A
S
LCVSPLHPSL
S
Q
V
Y
V
LTPRPQPPRSTPARSSPPRSG
D
P
T
L
L
E
Y
V
A
SLKPPRG
S
C
S
I
R
R
A
L
L
S
V
G
V
A
L
C
A
V
P
L
C
V
A
I
L
L
F
G
L
H
Y
W
A
V
T
LQE
K
S
Y
A
E
A
L
L
H
A
RMG
T
M
L
K
V
D
L
E
L
L
L
S
I
L
L
S
I
V
V
VGGGS
G
T
V
I
Y
V
V
L
Y
R
L
A
I
R
H
Q
V
R
A
F
A
L
C
V
R
L
A
D
T
LLPL
D
V
H
H
LAAEDSEGRQDIAMP
I
D
A
A
A
A
A
A
QQADNGD
S
R
A
Q
W
F
S
P
F
V
A
R
W
H
E
E
V
S
R
L
V
K
L
LTCPIEV
S
Q
A
E
W
R
S
F
L
F
S
E
R
R
SLALPNEGTNGSGDLP
V
T
ETTLADGPFHNSNNRRSLPFGVQASVPMTENEPWPPHEAQPGSR
Y
Q
M
S
E
A
V
F
SRRPQHPV
D
V
S
K
R
Q
E
A
V
T
V
V
V
C
R
LM
A
P
A
E
L
L
V
EQRPL
T
Q
A
Q
L
K
E
L
Q
R
L
S
N
E
F
H
Q
R
L
R
TVPRT
S
C
A
A
V
T
EV
G
V
S
E
V
V
F
SFNTFSP
L
P
S
L
VA
S
P
A
A
V
A
L
A
V
V
A
Q
K
A
L
V
EWSPTYRGTP
V
Q
W
G
I
A
V
H
R
F
D
A
Y
ICPTRGMQ
G
R
L
Y
V
S
FGT
V
E
Y
D
F
A
R
Q
L
A
E
L
A
A
L
F
D
Y
G
A
L
C
HAGFLADASCESQCL
P
V
D
Y
V
M
D
L
R
QQ
A
F
L
V
Y
Q
LHDGDV
D
R
E
Q
R
L
Q
M
N
S
A
I
A
S
MRNGE
Y
K
A
A
A
D
A
L
G
M
W
RRKSGGCSGL
P
R
T
A
A
H
L
R
Y
V
A
G
F
L
E
R
A
A
R
K
RRLRVSE
A
T
V
E
A
VTAPS
F
T
C
A
V
E
G
V
A
E
W
A
A
E
S
L
L
T
S
YFRPPPVWEEEEAPRAPSP
D
L
LRA
P
A
I
L
A
TSGGGSCGLRKRECGSS
N
V
L
V
P
FSPQPSRGAA
G
E
L
A
T
F
F
R
S
L
M
R
R
S
Y
Q
A
R
T
R
Y
V
L
S
A
E
Q
REGQVGSRAMGEPPH
Q
P
R
E
V
L
A
A
IEGDARP
P
S
S
L
Q
R
CYGLPSPGTESVSGERNVLEDGSAPLSPRDNVTGCSS
S
F
H
A
T
R
S
V
FEASTPTTTFPDVTCGDR
K
W
A
A
L
A
L
L
TEPDQ
S
T
V
T
V
TASRPRLFSNSWS
L
A
ESGVPEMPTL
T
P
L
T
S
G
V
L
RS
S
Q
S
D
V
R
R
Q
R
H
A
S
I
L
I
S
AAKKEDDAAG
P
V
A
A
CASAKDN
A
T
LRSSRGRRDSGGCRSERPRGRHGS
Q
F
TTEVP
T
S
D
E
L
S
S
R
L
L
G
H
Q
C
V
S
Q
L
T
D
T
T
I
A
RF
P
S
E
VSHESLSARSGS
V
R
RRASASTA
A
A
S
S
V
L
P
L
F
ADSMV
P
F
T
VQ
D
R
T
EAR
S
E
A
E
T
A
C
E
A
D
L
N
Q
E
L
S
M
M
S
V
A
Q
R
S
R
SRRSHRATAQP
S
S
V
V
C
S
C
T
R
RIDTSSS
N
T
V
M
V
F
Q
GFH-PD
G
Y
L
V
V
V
KRA
D
R
R
A
A
K
Q
V
A
Q
L
R
N
E
V
D
L
L
R
E
L
H
H
R
N
V
V
N
I
V
S
AWKDD
E
A
V
Y
F
A
M
E
Y
A
--
C
--
E
T
L
A
T
V
L
Q
K
F
K
V
L
L
P
G
V
V
R
F
Y
A
R
E
V
L
N
A
L
V
Y
L
H
RDC
G
I
I
HRDLSPN
N
V
I
I
TNTTDR
S
R
V
K
L
IDF
G
R
S
IMGPHFCSGSSGM
S
T
TVPGNA
S
L
E
F
T
E
QHSSRN
K
V
S
VTDVPTSVVGTPLFM
S
P
Q
A
CRG-L-AH-P
T
S
-
D
I
W
S
L
G
I
I
V
H
L
C
LTGTYPYPPETFT
D
P
E
T
F
V
A
NIGSGRL
T
P
V
I
A
D
T
C
EMT
G
E
A
R
S
F
I
E
Q
C
L
TLSHTER
P
S
A
A
A
L
L
K
HGFVER----------------------------------------------------------------
12
PsiBlast_PDB
87.28
28%
-104
- C2 -
-
2CDZ
1
A:
[56-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
-------
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
S
L
---------------------
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
-
P
Y
G
P
E
V
-
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
----------------------------------------------------------------
2
PsiBlast_PDB
87.05
28%
-105
- C2 -
-
4FIF
1
PAK4_HUMAN
A:
[99-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
-------
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
S
L
---------------------
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
-
P
Y
G
P
E
V
-
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
----------------------------------------------------------------
1
PsiBlast_PDB
86.60
28%
-105
- C2 -
-
4FIE
1
PAK4_HUMAN
A:
[176-406]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
-------
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
S
L
---------------------
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
-
P
Y
G
P
E
V
-
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
----------------------------------------------------------------
19
PsiBlast_PDB
86.55
28%
-112
- C2 -
-
2F57
1
PAK5_HUMAN
A:
[70-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
Q
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
-
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
S
D
---
G
R
I
K
L
S
D
F
G
-------
F
C
---
A
Q
V
S
K
E
V
P
K
R
K
S
L
---------------------
V
G
T
P
Y
W
M
A
P
E
V
I
S
R
-
L
-
P
Y
-
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
----
F
N
E
P
P
L
Q
A
M
R
R
I
R
D
S
L
P
P
R
V
K
D
L
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
L
K
-----------------------------------------------------------------
3
PsiBlast_PDB
86.53
28%
-105
- C2 -
-
4FIG
1
?
A:
[99-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
-------
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
S
L
---------------------
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
-
P
Y
G
P
E
V
-
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
----------------------------------------------------------------
14
PsiBlast_PDB
86.41
28%
-102
- C2 -
-
2Q0N
6
A:
[54-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
-------
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
S
L
---------------------
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
-
P
Y
G
P
E
V
-
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
----------------------------------------------------------------
16
PsiBlast_PDB
86.37
28%
-101
- C2 -
-
4APP
2
A:
[49-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
-------
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
S
L
---------------------
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
-
P
Y
G
P
E
V
-
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
----------------------------------------------------------------
15
PsiBlast_PDB
85.84
28%
-106
- C2 -
-
2X4Z
3
A:
[49-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
-------
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
S
L
---------------------
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
-
P
Y
G
P
E
V
-
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
----------------------------------------------------------------
9
PsiBlast_PDB
85.33
28%
-110
- C2 -
-
4XBU
-
PAK4_HUMAN
A:
[344-574]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
-------
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
S
L
---------------------
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
-
P
Y
G
P
E
V
-
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
----------------------------------------------------------------
7
PsiBlast_PDB
85.14
28%
-107
- C2 -
-
4JDH
-
?
A:
[99-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
-------
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
S
L
---------------------
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
-
P
Y
G
P
E
V
-
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
----------------------------------------------------------------
17
PsiBlast_PDB
84.20
28%
-110
- C2 -
-
4NJD
1
A:
[49-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
-------
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
S
L
---------------------
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
-
P
Y
G
P
E
V
-
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
----------------------------------------------------------------
13
PsiBlast_PDB
84.07
28%
-111
- C2 -
-
2J0I
4
A:
[56-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
-------
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
S
L
---------------------
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
-
P
Y
G
P
E
V
-
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
----------------------------------------------------------------
8
PsiBlast_PDB
84.07
28%
-107
- C2 -
-
4JDI
1
PAK4_HUMAN
A:
[99-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
-------
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
S
L
---------------------
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
-
P
Y
G
P
E
V
-
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
----------------------------------------------------------------
20
PsiBlast_PDB
83.84
28%
-108
- C2 -
-
4O0V
1
A:
[46-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
-------
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
S
L
---------------------
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
-
P
Y
G
P
E
V
-
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
----------------------------------------------------------------
18
PsiBlast_PDB
83.80
28%
-111
- C2 -
-
5I0B
1
PAK4_HUMAN
A:
[49-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
-------
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
S
L
---------------------
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
-
P
Y
G
P
E
V
-
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
----------------------------------------------------------------
5
PsiBlast_PDB
83.69
28%
-104
- C2 -
-
4FII
-
PAK4_HUMAN
A:
[99-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
-------
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
S
L
---------------------
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
-
P
Y
G
P
E
V
-
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
----------------------------------------------------------------
11
PsiBlast_PDB
83.31
28%
-100
- C2 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[119-349]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
-------
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
S
L
---------------------
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
-
P
Y
G
P
E
V
-
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
----------------------------------------------------------------
48
Fugue
82.63
18%
-44
- C2 -
-
1KOB
1
?
A:
[23-374]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
-
K
-
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
--
S
G
G
E
L
F
D
R
I
A
A
E
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
-
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
K
A
-
S
S
V
K
I
I
D
F
G
--------------
L
A
T
K
L
N
P
D
E
I
V
K
V
T
------------------
T
A
T
A
E
F
A
A
P
E
I
V
D
R
-
E
-
P
V
G
F
Y
T
-
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
---
D
D
L
E
T
L
Q
N
V
K
R
C
D
W
E
F
D
E
D
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
K
G
DHSNLTSRIPSSRY
N
K
I
R
Q
K
I
K
E
K
Y
ADWPAPQPAIGRIANFSSLRKHRPQEYQ
I
Y
D
S
Y
F
DRKEA
24
HHSearch
80.54
30%
-29
- C2 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[101-349]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
--
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
-
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--------------------
E
-----------
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-
L
P
Y
G
-
P
E
V
-
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
---
K
A
M
K
M
I
R
D
-
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
----------------------------------------------------------------
47
Fugue
80.23
20%
-35
- C2 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
-
T
-
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
-
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
E
L
V
M
I
F
E
F
I
SG
L
--
D
I
F
E
R
I
N
T
S
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
-
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
R
S
-
S
T
I
K
I
I
E
F
G
Q
A
--------------------------------
R
Q
L
K
P
G
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
D
V
-
V
S
-
T
A
T
-
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
---
T
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
T
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
KIERVSTKVIRT
L
K
H
R
R
Y
Y
H
T
L
IKKDLNMVVSAARISCGGAIRSQKG
V
S
V
A
K
V
K
V
A
SI------