@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_35_4050: (2018-03-13 )
MPDAQSASPGSVYSGGVPPMVWIQREQQRIPLQFSATGSPNLDGTRLREEGNEAFKAGRYHEAIRYYTQAIEVDPDSEFLYTNRSFAYFNIKEFEKSAADAAKAVEINANFFKGHYRLGLAQMSLNDFGHAMESLRKAWALAPSENKEAIRVAMAKCESKMARAPVTPLLMSPGDSSSVPYTETGVSSRSSWPTAPARPTDAQSALGSTSVDFCELEAGIRRAATLRDQAAKYAETYKAQDAIVECSKRSDKIKSLMSIATSSELSALSKEADEKQSQLRRAVRDQDSNAYHKARCDRDATLNKLWDTAAQAGMAIAQLKKIAKEEQNFFSRFGPASNRTLSNVPTEGTSDTLTAVTTPVAAESPPASAPIPPNEAPTDAGAPGTSLSRASCISPGSSTPTAEAVVPHQPLTTPRAGANHSTQSSTIAGAELDQLLRRRVEINEAVRKAQKCFAATDAAGQAFLHSLEAEAEAMKEVRSLLAEAVELDTQLETHARQVAQTTTKELSDVRLQALDQMSSVVERVKADKEAFVKTMREGDGLLEEEAKLEQQRLLHERQRIQLQAEIEWFKIRDEPENKIECLQVQVKRLHQRIAAIHEKQKAVQTRIMELVEQDHPELAWKSMANGSRILRLVKGSGLWQNLSFSDFQVLSTLSSTVNSKVYHALRRGEHVAVKEISIDDDAARRRFQREVNIVSTCNHPNIIRIKGVFFDGPFAYILLPYYHRGSLRALLSKQEPMSWVAVQDMLRQLASGVAYLHEHGIVHGDLKPSNVLIADDGRPVISDFGIAKDHGALGVADMTLTTTVTNTSNGCNSIVGTIQYMAPEQLLCETGSHTAKSTGMSDMWALGFTMLEVALENAFFHDASLGKPSLPLLLPEQKRIDVPAKAVGGDEKLAEAIASVLVADPANRATAYDLLAHPYFSSTLSSMNSNQNSSALAKSDERIDAVRSYIYAVRRSHQQKVLVSVSRSHMVESVRDIFQRLDNDDLLSPIMVVFQGEAGIDEGALTTEMLNLFYEQLILVKKALVCAASEEAGAASPHSAGSPVSSGTAAASASASNEPGIRSVLFSTVPYLPAPDADGIAPDLFVLLGKVLLKSIIENRQIPLQLSSAVLKFLSGAEPSFVDLEEYDPNIASTLKRLRLLSAADLEDAGLDFSYFTHEFLKTQTDGRYTTDSPLTPESVSDYINLREKFDLVERRRTALEAMRKGFYCEPSLEHHLKLLSPSDLLLLLCGQLHVSAQVIVDALEFQGFGRNSNTPKYLKEVLLDMSQNNLRRFLQLCTATAAVPVSGAMKKIKVLRCADEGRLPVGHGCTNQLDLPDYNDKQIIKEKLEIALAHASDGFHVV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......----660...--..--..670.....-..680.......690.......700.......710.------......720.......-730-....---...740.......750.......760.......770.......---780........790.......800.......810.......820.......830.......840.......850.......860.......870.......880..-------.....890.......900.......910.......920.......930.......940....--...950.......960.......970.......980--.-...-....990.......1000......1010......1020......1030......1040......1050......1060......1070....---.---.1080......1090......1100......1110......1120......1130......1140......1150......------1160--.........1170......1180......1190......1200......1210.....-.1220......1230......1240....-..1250......1260......1270......1280......1290------.......-.1300......1310......1320......1330......1340
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPDAQSASPGSVYSGGVP
P
M
V
W
I
QREQQRI
P
L
Q
F
SATGSPNLD
G
T
R
L
R
EEGN
E
A
F
KAG
R
Y
H
E
A
I
R
Y
Y
T
Q
A
I
EVDPDS
E
F
L
Y
TNR
S
F
A
Y
F
N
I
K
E
F
E
K
S
AADA
A
K
A
V
E
I
NA
N
F
FK
G
H
Y
R
L
G
L
A
QM
S
L
N
D
F
G
H
A
M
E
S
L
R
K
A
WALAPSE
N
K
E
A
I
R
V
A
M
A
K
C
E
S
K
MARAPVT
P
L
L
MSPGDSSSVPYTETGVSSRSSWPTAPARPT
D
A
Q
SALGSTSV
D
F
C
E
L
E
A
G
I
R
R
A
A
T
L
R
D
Q
A
A
K
Y
A
E
T
YKA
Q
D
A
I
V
E
C
S
K
R
S
D
K
I
K
S
L
M
S
I
A
T
S
S
E
L
S
A
L
S
K
E
A
D
E
K
Q
S
Q
L
R
R
A
V
RDQDSNA
Y
H
K
ARCDRD
A
T
L
N
K
L
W
D
T
A
A
Q
A
G
M
A
I
A
Q
L
K
K
I
A
K
E
E
Q
N
F
F
S
RFGPASNRTLSNVPTEGTSD
T
L
T
A
V
TTPVAAESPPASAPIPPNEAPTDAGAPGTSLSRASCISPGSSTPTAEAVVPHQPLTTPRAGANHSTQSSTI
A
G
A
E
L
D
Q
L
L
R
R
R
V
E
I
N
E
A
V
R
K
A
Q
K
C
F
AAT
D
A
A
G
Q
A
F
L
H
S
L
E
A
E
A
E
A
M
K
E
V
R
S
L
L
A
E
A
V
E
L
D
T
Q
L
E
T
H
A
R
Q
V
A
Q
T
T
T
K
E
L
S
D
V
R
L
Q
A
L
D
Q
M
S
S
V
V
E
R
V
KA
D
K
E
A
F
V
K
T
M
R
EGDG
L
L
E
E
E
A
K
L
E
Q
Q
R
L
L
H
E
R
Q
R
I
Q
L
Q
A
E
I
E
W
F
K
IRDEPEN
K
I
E
C
L
Q
V
Q
V
K
R
L
H
Q
R
I
A
A
I
H
E
K
Q
K
A
V
Q
T
R
I
M
E
L
V
EQDH
P
E
L
A
W
K
S
MAN
G
S
R
I
L
R
LVKGSGLWQNLS
F
S
D
F
Q
V
L
S
T
L
S
S
T
V
N
S
----
K
V
Y
H
A
L
--RR--G
E
H
V
A
V
K
E
I
S-ID
D
D
A
A
R
R
R
F
Q
R
EV
N
I
V
STCNHP
N
I
I
R
I
K
G
V
F
FDG
P
------
F
A
Y
I
L
L
P
YYHR
G
S
L
R
A
-
L
L
S-KQEP---
M
S
W
V
A
V
Q
D
M
L
R
Q
L
A
S
G
V
A
Y
L
H
EHGIVHGDLKPS
N
V
L
I
ADDGR
P
---
V
I
-
S
DFGIAKDHGAL
G
V
A
D
M
T
L
T
T
T
V
TNTSN
G
C
N
S
I
V
G
T
I
Q
YM
A
P
E
Q
L
L
CETGSHTAKSTG
M
S
D
M
W
A
L
G
F
T
M
L
E
V
A
L
E
N
AFFHDASLGKPSLPLLLPEQKRIDVPA-------KAVGG
D
E
K
L
A
E
A
I
A
S
V
L
VADPANR
A
T
A
Y
D
L
L
A
H
P
Y
F
S
S
T
L
S
SMNSNQNS
S
A
LAK
S
D
E
R
I
D
A
V
--
R
S
Y
I
Y
A
V
R
R
SH
Q
Q
K
V
L
V
S
V
S
R
S
H
M
V
E
S
V
R
D
I
F
Q
RL---D-ND
D
-
L
L
S
P
I
M
V
VFQGEAGIDEG
A
L
T
T
E
M
L
N
L
F
Y
E
Q
L
I
L
V
K
K
A
L
V
CAASEEAGAASPHSAGSPVSSGTAAASASASNEP
G
I
R
S
V
L
F
STVPYLPAPDA---D---GIA
P
D
L
F
V
L
L
G
K
V
L
L
K
S
I
I
ENRQI
P
L
Q
L
S
S
A
V
L
K
F
LSGAEP
S
F
V
D
L
E
EYDP
N
I
A
S
T
L
K
R
L
R
L
L
SAADLEDAGLD
F
S
Y
F
T
H
E
------
F
-----
L
KTQTDGRYTTDSPL
T
P
E
S
V
S
D
Y
I
N
L
R
E
K
F
D
L
V
E
R
R
R
T
A
L
E
A
M
R
KGFYCEP
S
L
E
H
H
L
K
-LL
S
P
S
D
L
L
L
L
L
C
GQL
H
V
S
A
Q
V
I
V
D
A
L
E
FQ-GFGRNSN
T
P
K
Y
L
K
E
V
L
L
DM
S
Q
N
N
L
R
R
F
L
Q
L
C
T
ATAAVPVSG
A
M
K
--------
K
I
K
V
L
R
C-ADEGRLPVGHGCTNQLDLPDY
N
D
K
Q
I
I
K
E
K
L
E
I
A
L
A
HASDGFHVV
24
HHSearch
76.02
25%
-58
- C3 -
-
3H1D
-
A:
[48-397]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
V
H
V
R
R
D
H
V
F
E
D
S
Y
R
E
L
H
R
K
---
S
-
P
E
E
-
M
K
N
R
L
Y
I
V
F
E
G
E
E
G
Q
D
A
G
G
L
L
R
E
W
Y
M
I
I
S
R
E
M
F
N
P
M
Y
A
L
F
R
T
S
P
G
D
------------------------------------
R
V
T
Y
T
I
N
P
S
---------
N
H
L
S
Y
F
K
F
V
G
R
I
V
A
K
A
V
Y
D
N
R
L
L
E
C
Y
F
T
R
S
F
Y
K
H
I
L
G
K
S
V
R
Y
T
D
M
E
S
E
D
Y
H
F
Y
Q
G
L
V
Y
L
L
E
N
D
V
S
T
L
-
G
Y
D
L
T
F
S
T
E
V
Q
E
------
F
G
V
A
E
V
R
D
L
K
P
N
G
A
---
N
I
L
V
T
E
E
N
K
K
E
Y
V
H
L
V
C
Q
M
R
M
T
G
A
I
R
K
Q
L
A
A
F
L
E
G
F
Y
E
I
I
P
-
K
R
L
I
S
-
I
F
T
E
Q
E
L
E
L
L
I
S
G
L
P
T
I
D
I
D
D
L
K
S
N
T
E
Y
H
-
K
Y
Q
S
N
S
I
Q
I
Q
W
F
W
R
A
L
R
S
F
D
Q
A
D
R
A
K
F
L
Q
F
V
T
G
T
S
K
V
P
L
Q
G
F
A
A
LEGMNGIQ
K
F
Q
I
H
R
D
D
R
S
T
D
R
L
P
S
A
H
T
C
F
N
Q
L
D
L
P
A
Y
E
S
F
E
K
L
R
H
M
L
L
L
A
I
Q
E
--------
25
HHSearch
70.30
24%
-19
- C3 -
-
3G1N
-
HUWE1_HUMAN
A:
[29-380]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
A
V
H
V
R
R
D
H
V
F
E
D
S
Y
R
E
L
H
R
K
---
S
-
P
E
E
-
M
K
N
R
L
Y
I
V
F
E
G
E
E
G
Q
D
A
G
G
L
L
R
E
W
Y
M
I
I
S
R
E
M
F
N
P
M
Y
A
L
F
R
T
S
P
G
D
------------------------------------
R
V
T
Y
T
I
N
P
S
S
---
H
CN-
P
N
H
L
S
Y
F
K
F
V
G
R
I
V
A
K
A
V
Y
D
N
R
L
L
E
C
Y
F
T
R
S
F
Y
K
H
I
L
G
K
S
V
R
Y
T
D
M
E
S
E
D
Y
H
F
Y
Q
G
L
V
Y
L
L
E
N
D
V
S
T
L
-
G
Y
D
L
T
F
S
T
E
V
Q
E
FG
V
C
E
-
V
-----
R
D
L
K
P
N
G
A
---
N
I
L
V
T
E
E
N
K
K
E
Y
V
H
L
V
C
Q
M
R
M
T
G
A
I
R
K
Q
L
A
A
F
L
E
G
F
Y
E
I
I
P
-
K
R
L
I
S
-
I
F
T
E
Q
E
L
E
L
L
I
S
G
L
P
T
I
D
I
D
D
L
K
S
N
T
E
Y
H
-
K
Y
Q
S
N
S
I
Q
I
Q
W
F
W
R
A
L
R
S
F
D
Q
A
D
R
A
K
F
L
Q
F
V
T
G
T
S
K
V
P
L
Q
G
F
A
A
L
E
G
MNGIQ
K
F
Q
I
H
R
D
D
R
S
T
D
R
L
P
S
A
H
T
C
F
N
Q
L
D
L
P
A
Y
E
S
F
E
K
L
R
H
M
L
L
L
A
I
Q
E
--------
21
HHSearch
68.00
25%
-21
- C3 -
-
5LP8
-
HUWE1_HUMAN
A:
[92-448]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
A
V
H
V
R
R
D
H
V
F
E
D
S
Y
R
E
L
H
R
K
---
S
-
P
E
E
-
M
K
N
R
L
Y
I
V
F
E
G
E
E
G
Q
D
A
G
G
L
L
R
E
W
Y
M
I
I
S
R
E
M
F
N
P
M
Y
A
L
F
R
T
S
P
G
------------------------------------
D
R
V
T
Y
T
I
N
P
S
S
---
H
CN-
P
N
H
L
S
Y
F
K
F
V
G
R
I
V
A
K
A
V
Y
D
N
R
L
L
E
C
Y
F
T
R
S
F
Y
K
H
I
L
G
K
S
V
R
Y
T
D
M
E
S
E
D
Y
H
F
Y
Q
G
L
V
Y
L
L
E
N
D
V
S
T
L
-
G
Y
D
L
T
F
S
T
E
V
Q
E
------
F
G
V
C
E
V
R
D
L
K
P
N
G
A
---
N
I
L
V
T
E
E
N
K
K
E
Y
V
H
L
V
C
Q
M
R
M
T
G
A
I
R
K
Q
L
A
A
F
L
E
G
F
Y
E
I
I
P
-
K
R
L
I
S
-
I
F
T
E
Q
E
L
E
L
L
I
S
G
L
P
T
I
D
I
D
D
L
K
S
N
T
E
Y
H
-
K
Y
Q
S
N
S
I
Q
I
Q
W
F
W
R
A
L
R
S
F
D
Q
A
D
R
A
K
F
L
Q
F
V
T
G
T
S
K
V
P
L
Q
G
F
A
A
LEGMNGIQ
K
F
Q
I
H
R
D
D
R
S
T
D
R
L
P
S
A
H
T
C
F
N
Q
L
D
L
P
A
Y
E
S
F
E
K
L
R
H
M
L
L
L
A
I
Q
E
C
S
E
G
F
G
--
26
HHSearch
67.58
22%
-36
- C3 -
-
1ND7
-
WWP1_HUMAN
A:
[566-915]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
K
I
N
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
A
L
---
K
-
P
Y
D
-
L
R
R
R
L
Y
V
I
F
R
G
E
E
G
L
D
Y
G
G
L
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
------------------------------------
N
Y
C
L
Q
I
N
P
A
S
---
T
IN-
P
D
H
L
S
Y
F
C
F
I
G
R
F
I
A
M
A
L
F
H
G
K
F
I
D
T
G
F
S
L
P
F
Y
K
R
M
L
S
K
K
L
T
I
K
D
L
E
S
I
D
T
E
F
Y
N
S
L
I
W
I
R
D
N
N
I
E
E
-
C
G
L
E
M
Y
F
S
V
D
M
E
I
------
L
GKV
T
S
H
D
L
K
L
G
G
S
---
N
I
L
V
T
E
E
N
K
D
E
Y
I
G
L
M
T
E
W
R
F
S
R
G
V
Q
E
Q
T
K
A
F
L
D
G
F
N
E
V
V
P
-
L
Q
W
L
Q
-
Y
F
D
E
K
E
L
E
V
M
L
C
G
M
Q
E
V
D
L
A
D
W
Q
R
N
T
V
Y
R
-
H
Y
T
R
N
S
K
Q
I
I
W
F
W
Q
F
V
K
E
T
D
N
E
V
R
M
R
L
L
Q
F
V
T
G
T
C
R
L
P
L
G
G
F
A
E
LMGSNGPQ
K
F
C
I
E
K
V
-
G
K
D
T
W
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
K
E
K
L
L
F
A
I
E
E
--------
12
PsiBlast_PDB
67.03
25%
-29
- C2 -
-
3COM
-
STK4_HUMAN
A:
[30-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
V
L
E
K
L
G
----
G
----
S
V
Y
K
A
I
--
H
K
ET
G
Q
I
V
A
I
K
Q
V
P
-
V
E
S
D
L
--
Q
E
I
I
K
E
I
S
I
M
Q
Q
C
D
S
P
H
V
V
K
Y
Y
G
S
Y
F
K
N
T
------
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
-
I
I
R
L
R
N
K
T
---
L
T
E
D
E
I
A
T
I
L
Q
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
D
I
K
A
G
N
I
L
L
N
T
E
G
H
A
---
K
L
-
A
D
F
G
V
A
---
G
Q
L
-----------
T
D
T
M
A
K
R
N
T
V
I
G
T
P
F
W
M
A
P
E
-
V
I
Q
E
I
G
Y
N
C
-----
V
A
D
I
W
S
L
G
I
T
A
I
E
M
A
----------
E
G
K
P
P
Y
A
D
I
H
P
M
R
A
I
F
M
I
P
T
NPPPTFR
K
P
E
L
W
S
D
N
F
T
D
F
V
K
Q
C
L
V
K
S
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
V
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
66.64
21%
-29
- C3 -
-
5C91
1
A:
[23-374]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
F
E
M
K
L
R
R
A
T
V
L
E
D
S
Y
R
R
I
M
G
V
---
K
-
R
A
D
F
L
K
A
R
L
W
I
E
F
D
G
E
K
G
L
D
Y
G
G
V
A
R
E
W
F
F
L
I
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
T
D
------------------------------------
N
Y
T
L
Q
I
N
P
N
S
GLC
N
---
E
D
H
L
S
Y
F
K
F
I
G
R
V
A
G
M
A
V
Y
H
G
K
L
L
D
G
F
F
I
R
P
F
Y
K
M
M
L
H
K
P
I
T
L
H
D
M
E
S
V
D
S
E
Y
Y
N
S
L
R
W
I
L
E
N
D
---
P
T
E
L
D
L
R
F
I
I
D
E
E
L
------
F
G
Q
T
H
Q
H
E
L
K
N
G
G
S
---
E
I
V
V
T
N
K
N
K
K
E
Y
I
Y
L
V
I
Q
W
R
F
V
N
R
I
Q
K
Q
M
A
A
F
K
E
G
F
F
E
L
I
P
-
Q
D
L
I
K
-
I
F
D
E
N
E
L
E
L
L
M
C
G
L
G
D
V
D
V
N
D
W
R
E
H
T
K
Y
K
N
G
Y
S
A
N
H
Q
V
I
Q
W
F
W
K
A
V
L
M
M
D
S
E
K
R
I
R
L
L
Q
F
V
T
G
T
S
R
V
P
M
N
G
F
A
E
L
Y
G
SNGPQ
S
F
T
V
E
Q
W
-
G
T
P
E
K
L
P
R
A
H
T
C
F
N
R
L
D
L
P
P
Y
E
S
F
E
E
L
W
D
K
L
Q
M
A
I
E
N
--------
15
PsiBlast_PDB
66.30
24%
-21
- C2 -
-
5DH3
1
STK3_HUMAN
A:
[29-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
V
L
E
K
L
G
E
G
S
Y
G
----
S
V
F
K
A
I
--
H
K
ES
G
Q
V
V
A
I
K
Q
V
P
-
V
E
S
D
L
--
Q
E
I
I
K
E
I
S
I
M
Q
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
N
T
------
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
-
I
I
R
L
R
N
K
T
---
L
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
D
I
K
A
G
N
I
L
L
N
T
E
G
H
A
---
K
L
-
A
D
F
G
V
A
G
Q
--------------
L
T
D
T
M
A
K
R
N
T
V
I
G
T
P
F
W
M
A
P
E
-
V
I
Q
E
I
G
Y
N
C
-----
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
----------
E
G
K
P
P
Y
A
D
I
H
P
M
R
A
I
F
M
I
P
T
NPPPTFR
K
P
E
L
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
I
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
65.07
22%
-33
- C3 -
-
5TJ7
-
WWP2_HUMAN
D:
[95-445]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
V
K
I
S
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
N
M
---
K
-
P
Y
D
-
L
R
R
R
L
Y
I
I
M
R
G
E
E
G
L
D
Y
G
G
I
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
------------------------------------
N
N
Y
C
L
Q
I
N
P
A
S
---
S
IN-
P
D
H
L
T
Y
F
R
F
I
G
R
F
I
A
M
A
L
Y
H
G
K
F
I
D
T
G
F
T
L
P
F
Y
K
R
M
L
N
K
R
P
T
L
K
D
L
E
S
I
D
P
E
F
Y
N
S
I
V
W
I
K
E
N
N
L
E
-
E
C
G
L
E
L
Y
F
I
Q
D
M
E
I
------
L
GKVTT
H
E
L
K
E
G
G
E
---
S
I
R
V
T
E
E
N
K
E
E
Y
I
M
L
L
T
D
W
R
F
T
R
G
V
E
E
Q
T
K
A
F
L
D
G
F
N
E
V
A
P
-
L
E
W
L
R
-
Y
F
D
E
K
E
L
E
L
M
L
C
G
M
Q
E
I
D
M
S
D
W
Q
K
S
T
I
Y
R
-
H
Y
T
K
N
S
K
Q
I
Q
W
F
W
Q
V
V
K
E
M
D
N
E
K
R
I
R
L
L
Q
F
V
T
G
T
C
R
L
P
V
G
G
F
A
E
LIGSNGPQ
K
F
C
I
D
K
V
-
G
K
E
T
W
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
R
E
K
L
L
Y
A
I
E
E
--------
29
HHSearch
64.95
27%
-4
- C3 -
-
1C4Z
-
UBE3A_HUMAN
A:
[499-846]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
R
L
K
V
R
R
D
H
I
I
D
D
A
L
V
R
L
E
M
I
A
M
E
N
-
P
A
D
-
L
K
K
Q
L
Y
V
E
F
E
G
E
Q
G
V
D
E
G
G
V
S
K
E
F
F
Q
L
V
V
E
E
I
F
N
P
D
I
G
M
F
T
Y
D
E
S
-------------------------------------
T
K
L
F
W
F
N
P
S
S
---
F
----
E
T
E
G
Q
F
T
L
I
G
I
V
L
G
L
A
I
Y
N
N
C
I
L
D
V
H
F
P
M
V
V
Y
R
K
L
M
G
K
K
G
T
F
R
D
L
G
D
S
H
P
V
L
Y
Q
S
L
K
D
L
L
E
Y
E
G
N
V
E
D
D
M
M
I
T
F
Q
I
S
Q
T
D
LFG
N
P
M
M
-----
Y
D
L
K
E
N
G
D
---
K
I
P
I
T
N
E
N
R
K
E
F
V
N
L
Y
S
D
Y
I
L
N
K
S
V
E
K
Q
F
K
A
F
R
R
G
F
H
M
V
T
N
E
-
S
P
L
K
Y
L
F
R
P
E
E
I
E
L
L
I
C
G
S
R
N
L
D
F
Q
A
L
E
E
T
T
E
Y
D
G
G
Y
T
R
D
S
V
L
I
R
E
F
W
E
I
V
H
S
F
T
D
E
Q
K
R
L
F
L
Q
F
T
T
G
T
D
R
A
P
V
G
G
L
G
K
L-------
K
M
I
I
A
K
N
G
P
D
T
E
R
L
P
T
S
H
T
C
F
N
V
L
L
L
P
E
Y
S
S
K
E
K
L
K
E
R
L
L
K
A
I
T
Y
-
A
------
43
Fugue
64.78
16%
-
- C2 -
-
3QA8
-
?
A:
[16-666]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
K
E
R
L
G
T
G
G
F
G
----
Y
V
L
R
W
I
--
H
Q
DT
G
E
Q
V
A
I
K
Q
C
R
Q
E
L
S
P
K
N
R
E
R
W
C
L
E
I
Q
I
M
K
K
L
N
H
P
N
V
V
S
A
R
E
V
P
D
G
L
Q
KLAPND
L
P
L
L
A
M
E
Y
C
E
G
G
D
L
R
K
-
Y
L
N
-
Q
F
E
N
CCG
L
K
E
G
P
I
R
T
L
L
S
D
I
S
S
A
L
R
Y
L
H
E
N
R
I
I
H
R
D
L
K
P
E
N
I
V
L
Q
P
G
P
Q
R
L
I
H
K
I
-
I
D
L
G
Y
A
K
E
L
D
---------------
Q
G
E
L
C
T
E
F
V
G
T
L
Q
Y
L
A
P
E
L
L
------
E
Q
K
K
Y
T
V
T
V
D
Y
W
S
F
G
T
L
A
F
E
C
I
T
G
F
---------
R
P
F
L
P
N
--
W
Q
P
V
Q
W
H
G
K
V
-------
R
I
V
V
Y
D
D
L
T
G
A
V
K
F
S
S
V
L
P
T
P
N
H
L
S
G
I
L
A
G
K
L
E
R
W
L
Q
C
M
L
M
W
H
Q
R
T
D
P
Q
N
P
N
V
G
C
F
Q
A
L
D
S
I
L
S
L
K
L
L
S
V
M
N
M
V
S
G
R
V
H
T
Y
P
V
T
E
N
E
N
L
Q
N
L
K
S
W
L
Q
Q
D
---
T
-
G
I
P
-
E
E
E
Q
E
L
L
Q
A
S
G
L
A
L
N
S
A
Q
P
L
T
Q
Y
V
I
D
C
T
V
G
D
L
I
F
L
F
D
N
-----
R
K
I
S
L
P
A
H
P
E
S
V
S
I
V
L
Q
D
P
K
R
P
L
T
Y
T
H
L
R
R
V
W
G
Q
I
W
Q
T
I
R
A
L
K
E
D
C
A
R
L
---
L
---
Q
G
Q
R
T
S
M
V
N
L
L
R
Y
N
T
E
L
S
K
K
K
N
S
M
T
S
E
C
E
Q
L
K
A
K
L
D
F
F
R
S
S
I
Q
I
D
L
E
K
Y
S
E
Q
M
E
F
G
I
T
S
E
K
L
L
S
A
W
R
E
M
E
Q
A
V
E
L
C
G
R
E
R
E
------
V
-----
Q
A
L
V
D
K
M
M
A
L
Q
T
D
S
V
D
L
Q
R
N
P
T
L
D
D
L
E
E
Q
A
R
D
L
Y
R
R
L
R
E
R
P
R
D
Q
R
T
P
G
D
S
N
D
M
V
R
L
L
I
-
L
A
I
Q
S
F
E
K
R
V
I
L
I
Y
D
Q
L
S
K
T
V
V
C
K
R
K
A
L
E
-
L
S
P
K
V
K
E
V
M
N
L
M
R
E
D
E
K
I
V
V
R
R
Q
E
K
R
Q
Q
E
L
W
N
L
L
K
I
A
C
S
K
V
R
---------------------------------------------------------------
5
PsiBlast_PDB
64.75
25%
-35
- C2 -
-
4AOT
1
STK10_HUMAN
A:
[21-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
----
K
V
Y
K
A
K
--
N
K
ET
G
A
L
A
A
A
K
V
I
E
-
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
-
L
D
R
G
---
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
---
R
L
-
A
D
F
G
V
S
A
---------------------------
G
T
P
Y
W
M
A
P
E
V
V
M
--------
Y
D
Y
K
-
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
S
-------
K
---
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
64.20
21%
-28
- C3 -
-
5HPL
-
RSP5_YEAST
B:
[454-802]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
C
H
I
K
V
R
R
K
N
I
F
E
D
A
Y
Q
E
I
M
R
Q
---
T
-
P
E
D
-
L
K
K
R
L
M
I
K
F
D
G
E
E
G
L
D
Y
G
G
V
S
R
E
F
F
F
L
L
S
H
E
M
F
N
P
F
Y
C
L
F
E
Y
S
A
Y
D
------------------------------------
N
Y
T
I
Q
I
N
P
N
S
---
G
IN-
P
E
H
L
N
Y
F
K
F
I
G
R
V
V
G
L
G
V
F
H
R
R
F
L
D
A
F
F
V
G
A
L
Y
K
M
M
L
R
K
K
V
V
L
Q
D
M
E
G
V
D
A
E
V
Y
N
S
L
N
W
M
L
E
N
S
I
D
--
G
V
L
D
L
T
F
S
A
D
D
E
R
------
F
G
E
V
V
T
V
D
L
K
P
D
G
R
---
N
I
E
V
T
D
G
N
K
K
E
Y
V
E
L
Y
T
Q
W
R
I
V
D
R
V
Q
E
Q
F
K
A
F
M
D
G
F
N
E
L
I
P
-
E
D
L
V
T
-
V
F
D
E
R
E
L
E
L
L
I
G
G
I
A
E
I
D
I
E
D
W
K
K
H
T
D
Y
R
-
G
Y
Q
E
S
D
E
V
I
Q
W
F
W
K
C
V
S
E
W
D
N
E
Q
R
A
R
L
L
Q
F
T
T
G
T
S
R
I
P
V
N
G
F
K
D
LQGSDGPR
R
F
T
I
E
K
A
-
G
E
V
Q
Q
L
P
K
S
H
T
C
F
N
R
V
D
L
P
Q
Y
V
D
Y
D
S
M
K
Q
K
L
T
L
A
V
E
E
--------
41
Fugue
64.05
20%
-2
- C2 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
GSF
G
E
V
H
R
M
E
D
K
Q
T
--
G
F
Q
C
A
V
K
K
V
R
-
L
E
V
F
R
-----
A
E
E
L
M
A
C
A
G
L
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
------
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
-
L
V
K
-
E
Q
G
C
---
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
H
---
A
A
L
C
D
F
G
H
A
V
C
----------------------
L
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
L
G
R
S
C
D
A
------
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
F
F
R
G
P
L
C
L
K
I
A
S
E
P
P
P
V
R
E
I
P
P
-------
S
C
---
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
62.52
25%
-28
- C2 -
-
5AJQ
2
STK10_HUMAN
A:
[18-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
----
K
V
Y
K
A
K
--
N
K
ET
G
A
L
A
A
A
K
V
I
E
----
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
-
L
D
R
G
---
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
---
R
L
-
A
D
F
G
V
S
A
K
N
--------------
L
K
T
------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
-
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
S
-------
K
---
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
62.47
21%
-25
- C3 -
-
2ONI
-
NED4L_HUMAN
A:
[42-391]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
E
M
K
L
H
R
N
N
I
F
E
E
S
Y
R
R
I
M
S
V
---
K
R
P
D
V
-
L
K
A
R
L
W
I
E
F
E
-
E
K
G
L
D
Y
G
G
V
A
R
E
W
F
F
L
L
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
T
D
------------------------------------
N
Y
T
L
Q
I
N
P
N
S
---
G
LCN
E
D
H
L
S
Y
F
T
F
I
G
R
V
A
G
L
A
V
F
H
G
K
L
L
D
G
F
F
I
R
P
F
Y
K
M
M
L
G
K
Q
I
T
L
N
D
M
E
S
V
D
S
E
Y
Y
N
S
L
K
W
I
L
E
N
D
---
P
T
E
L
D
L
M
F
C
I
D
E
E
N
------
F
G
Q
T
Y
Q
V
D
L
K
P
N
G
S
---
E
I
M
V
T
N
E
N
K
R
E
Y
I
D
L
V
I
Q
W
R
F
V
N
R
V
Q
K
Q
M
N
A
F
L
E
G
F
T
E
L
L
P
-
I
D
L
I
K
-
I
F
D
E
N
E
L
E
L
L
M
C
G
L
G
D
V
D
V
N
D
W
R
Q
H
S
I
Y
K
N
G
Y
C
P
N
H
P
V
I
Q
W
F
W
K
A
V
L
L
M
D
A
E
K
R
I
R
L
L
Q
F
V
T
G
T
S
R
V
P
M
N
G
F
A
E
LYGSNGPQ
L
F
T
I
E
Q
W
-
G
S
P
E
K
L
P
R
A
H
T
C
F
N
R
L
D
L
P
P
Y
E
T
F
E
D
L
R
E
K
L
L
M
A
V
E
---------
31
HHSearch
62.27
21%
-31
- C3 -
-
1ZVD
-
SMUF2_HUMAN
A:
[24-373]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
C
R
I
E
V
S
R
E
E
I
F
E
E
S
Y
R
Q
V
M
K
M
---
R
-
P
K
D
-
L
W
K
R
L
M
I
K
F
R
G
E
E
G
L
D
Y
G
G
V
A
R
E
W
L
Y
L
L
S
H
E
M
L
N
P
Y
Y
G
L
F
Q
Y
S
R
D
D
------------------------------------
I
Y
T
L
Q
I
N
P
D
S
---
A
VN-
P
E
H
L
S
Y
F
H
F
V
G
R
I
M
G
M
A
V
F
H
G
H
Y
I
D
G
G
F
T
L
P
F
Y
K
Q
L
L
G
K
S
I
T
L
D
D
M
E
L
V
D
P
D
L
H
N
S
L
V
W
I
L
E
N
D
I
T
--
G
V
L
D
H
T
F
C
V
E
H
N
A
------
Y
G
E
I
I
Q
H
E
L
K
P
N
G
K
---
S
I
P
V
N
E
E
N
K
K
E
Y
V
R
L
Y
V
N
W
R
F
L
R
G
I
E
A
Q
F
L
A
L
Q
K
G
F
N
E
V
I
P
-
Q
H
L
L
K
-
T
F
D
E
K
E
L
E
L
I
I
C
G
L
G
K
I
D
V
N
D
W
K
V
N
T
R
L
K
-
H
C
T
P
D
S
N
I
V
K
W
F
W
K
A
V
E
F
F
D
E
E
R
R
A
R
L
L
Q
F
V
T
G
S
S
R
V
P
L
Q
G
F
K
A
LQGAAGPR
L
F
T
I
H
Q
I
D
A
C
T
N
N
L
P
K
A
H
T
C
F
N
R
I
D
I
P
P
Y
E
S
Y
E
K
L
Y
E
K
L
L
T
A
I
E
E
--------
8
PsiBlast_PDB
61.49
25%
-32
- C2 -
-
4BC6
2
STK10_HUMAN
A:
[13-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
----
K
V
Y
K
A
K
--
N
K
ET
G
A
L
A
A
A
K
V
I
E
-
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
-
L
D
R
G
---
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
---
R
L
-
A
D
F
G
V
S
A
K
N
--------------
L
K
T
L
Q
--------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
-
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
S
-------
K
---
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
61.20
25%
-18
- C2 -
-
4LGD
1
STK3_HUMAN
A:
[28-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
V
L
E
K
L
G
E
G
S
Y
G
----
S
V
F
K
A
I
--
H
K
ES
G
Q
V
V
A
I
K
Q
V
P
-
V
E
S
D
L
--
Q
E
I
I
K
E
I
S
I
M
Q
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
N
T
------
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
-
I
I
R
L
R
N
K
T
---
L
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
N
I
K
A
G
N
I
L
L
N
T
E
G
H
A
---
K
L
-
A
D
F
G
V
A
---
G
Q
L
-----------
T
D
T
M
A
K
R
N
T
V
I
G
T
P
F
W
M
A
P
E
-
V
I
Q
E
I
G
Y
N
C
-----
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
----------
E
G
K
P
P
Y
A
D
I
H
P
M
R
A
I
F
M
I
P
T
NPPPTFR
K
P
E
L
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
I
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
60.94
22%
-25
- C3 -
-
5HPS
-
WWP1_HUMAN
A:
[566-915]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
K
I
N
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
A
L
---
K
-
P
Y
D
-
L
R
R
R
L
Y
V
I
F
R
G
E
E
---
Y
G
G
L
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
------------------------------------
N
Y
C
L
Q
I
N
P
A
S
---
T
IN-
P
D
H
L
S
Y
F
C
F
I
G
R
F
I
A
M
A
L
F
H
G
K
F
I
D
T
G
F
S
L
P
F
Y
K
R
M
L
S
K
K
L
T
I
K
D
L
E
S
I
D
T
E
F
Y
N
S
L
I
W
I
R
D
N
N
I
E
E
-
C
G
L
E
M
Y
F
S
V
D
M
E
I
------
L
G
K
V
T
S
H
D
L
K
L
G
G
S
---
N
I
L
V
T
E
E
N
K
D
E
Y
I
G
L
M
T
E
W
R
F
S
R
G
V
Q
E
Q
T
K
A
F
L
D
G
F
N
E
V
V
P
-
L
Q
W
L
Q
-
Y
F
D
E
K
E
L
E
V
M
L
C
G
M
Q
E
V
D
L
A
D
W
Q
R
N
T
V
Y
R
-
H
Y
T
R
N
S
K
Q
I
I
W
F
W
Q
F
V
K
E
T
D
N
E
V
R
M
R
L
L
Q
F
V
T
G
T
C
R
L
P
L
G
G
F
A
E
LMGSNGPQ
K
F
C
I
E
K
V
-
G
K
D
T
W
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
K
E
K
L
L
F
A
I
E
E
--------
7
PsiBlast_PDB
60.82
25%
-27
- C2 -
-
4USE
1
STK10_HUMAN
A:
[21-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
----
K
V
Y
K
A
K
--
N
K
ET
G
A
L
A
A
A
K
V
I
E
-
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
-
L
D
R
G
---
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
---
R
L
-
A
D
F
G
V
S
A
K
N
--------------
L
K
T
L
Q
-------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
-
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
S
-------
K
---
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------