@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_36_1580: (2018-03-13 )
MSGGNAGDAMIGRVCRNFPDTFAKDEATAREQDKKYWISRVLGSGATGTVLCAKRVSDGEGFAVKCVDMEGMSEADKNRAQAEVDCLLNCDFFSIVKCHEDLAKRDANNPEMVQMIALVLDYANAGDLRQEIKSRARTGRTFREHEAGLLFLQVLLAVHHVHSKHMIHRDIKSANILLCSNGLVKLGDFGFSKMYANTVSDDVGRTFCGTPYYVAPEIWRRCPYSKKADMFSLGVLLYELLTLKRPFDGANMHEVMHKTLAGRFDPLPSNISPEMRDIVTALLSGDPGRRPSSSRLLNMPICKLFLSGLLEIVQTQPAFQGGLRDSISNQIQETKRLLVTEKRHIQRMMEESSGSSVAASTTILEGATPLTTTLGGLTIHEGTVKKQSSDMVWKKRYLCIRAELADGQTVLDMNPKFKTLDMVLAISKETMEQQCISTPFTELEDAFPVPAKYTGCNASFVFAVAFKTGKRLSFQTKSEVERDLWMEKIQDVLGIGDGDDDDMSALPAKE
Atome Classification :
(20 SA)
----------------------------------------.........10........20........30........40........50........60........70...-.....80........90........100.......110.......120.......130.......140.......150.......160...-----....170.......180.......190......-..200.......210.......220-----.-......230.......240.......250.......260--.........270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------------MSGGN
A
G
D
A
M
I
G
R
V
C
RNF
P
D
T
FAKDE
A
T
A
R
E
Q
D
K
K
Y
W
I
S
R
V
LGSGA
T
G
T
V
L
C
A
K
RVSDGE
G
F
A
V
K
C
V
DMEGM
S
E
-
A
DKNRAQ
A
E
V
D
C
L
LNC
D
F
F
S
I
V
K
C
H
E
D
L
A
KRDAN
N
P
E
M
V
Q
M
I
A
L
V
L
DYA
N
A
G
D
L
R
Q
E
I
K
S
R
ARTGR
T
F
R
E
H
E
A
G
L
L
F
L
Q
V
L
L
A
V
H
H
V
H
S
K
H
-----
M
I
H
R
DIKSA
N
I
L
L
CSNG
L
V
KLGDF
G
-
F
S
K
M
Y
A
N-TV
S
D
DVGRTFCGTPYYV
A
P
E
I
W
R
RC-----P-YSKK
A
D
M
F
S
L
G
V
L
L
Y
E
L
L
T
LKRPFDG
A
N
M
H
E
V
M
H
K
T
L----AGRFDPLPSNI
S
P
E
M
R
D
I
V
T
A
L
LSGDPGRRPSSSRLLN
M
P
I
C
K
L
F
L
S
G
L
L
E
I
VQTQPAFQGG
L
R
D
S
I
S
N
Q
I
Q
E
T
K
R
L
L
V
T
E
K
R
H
I
Q
R
M
M
E
ESSGSSV
A
A
S
T
T
ILEGATP
L
T
T
TLG
G
L
T
IHEGTVKKQSS
D
M
V
W
K
K
R
Y
L
C
I
R
A
ELADG
Q
T
V
L
DMNPKF
K
T
L
D
M
V
L
A
I
S
K
E
T
M
E
Q
Q
CIST
P
F
T
E
L
EDAFPVPAKYTGCN
A
S
F
V
F
A
V
A
FKTG
K
R
L
S
F
Q
T
K
S
E
V
E
R
D
L
W
M
E
K
I
Q
D
V
LGIGDGDDD
D
M
SALPAKE
41
HHSearch
76.67
34%
-130
- C1 -
-
4APC
-
NEK1_HUMAN
B:
[19-284]
--------------------------------------------------------------------
Y
F
Q
S
M
E
K
Y
V
R
L
Q
K
I
G
-----
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
S
S
-
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
N
--------
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
Q
K
--
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-----
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
G
T
V
Q
L
G
D
F
G
-
I
A
R
V
L
N
S
-
T
V
--
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
N
K
-----
P
-
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
I
----
S
G
S
F
P
P
V
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
I
L
E
K
G
F
I
A
K
R
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
75.20
34%
-131
- C1 -
-
4APC
-
NEK1_HUMAN
A:
[24-275]
-------------------------------------------------------------------------
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
S
S
-
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
N
G
S
--------
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
--
A
Q
K
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-----
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
G
T
V
Q
L
G
D
F
G
-
I
A
R
V
L
N
S
-
T
V
--
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
N
K
-----
P
-
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
I
----
S
G
S
F
P
P
V
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.15
31%
-117
- C1 -
-
2W5A
5
NEK2_HUMAN
A:
[3-270]
--------------------------------------------------------------------
S
R
A
E
D
--
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
------
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
------
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
-
L
A
R
I
L
----
T
S
--
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
-------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
K
F
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.78
34%
-129
- C1 -
-
4B9D
1
NEK1_HUMAN
A:
[24-275]
-------------------------------------------------------------------------
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
S
S
-
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
N
G
S
--------
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
--
A
Q
K
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-----
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
G
T
V
Q
L
G
D
F
G
-
I
A
R
V
L
N
S
-
T
V
--
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
N
K
-----
P
-
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
I
----
S
G
S
F
P
P
V
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
73.11
27%
4
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
GPAQTNGQCFS
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
--------
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
---
K
F
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
-----
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
S
V
A
V
---
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
GGKG
R
-
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
HKE
R
F
Q
F
P
T
Q
V
T
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
S
R
E
H
R
L
G
Q
N
G
---------------
I
E
D
F
K
K
H
P
F
F
S
G
I
D
W
D
N
I
R
N
C
-------------
E
A
P
Y
I
P
E
V
S
S
P
T
D
----
T
S
N
F
D
V
D
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
---------
C
L
R
-------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
69.97
31%
-118
- C1 -
-
2XNM
10
NEK2_HUMAN
A:
[3-270]
--------------------------------------------------------------------
S
R
A
E
D
--
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
------
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
---------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
-
L
A
R
I
L
------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
------
S
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
K
F
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
69.62
31%
-124
- C1 -
-
2XKF
1
NEK2_HUMAN
A:
[3-270]
--------------------------------------------------------------------
S
R
A
E
D
--
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
------
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
-------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
------
S
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
K
F
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
68.92
31%
-117
- C1 -
-
2XNO
13
NEK2_HUMAN
A:
[3-270]
--------------------------------------------------------------------
S
R
A
E
D
--
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
------
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
-------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
K
F
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
68.80
31%
-120
- C1 -
-
2XNP
6
NEK2_HUMAN
A:
[3-270]
--------------------------------------------------------------------
S
R
A
E
D
--
Y
E
V
L
Y
T
I
G
T
G
-
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
------
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-------
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
-
L
----------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
K
F
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
67.44
31%
-119
- C1 -
-
2XK4
1
NEK2_HUMAN
A:
[3-270]
--------------------------------------------------------------------
S
R
A
E
D
--
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
------
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
-
L
----------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
--------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
K
F
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
66.51
30%
-114
- C1 -
-
5K00
1
MELK_HUMAN
A:
[6-268]
-----------------------------------------------------------------------
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
-
G
-
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
--------
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
----
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
-----
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
-
L
C
A
K
P
---------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
-----
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
----
R
G
K
Y
-
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
65.59
31%
-113
- C1 -
-
2XNN
6
NEK2_HUMAN
A:
[3-270]
--------------------------------------------------------------------
S
R
A
E
D
--
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
------
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
--------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
K
F
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
64.55
31%
-126
- C1 -
-
2XK6
1
NEK2_HUMAN
A:
[4-270]
---------------------------------------------------------------------
R
A
E
D
--
Y
E
V
L
Y
T
I
G
-----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
------
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
---------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
K
F
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.93
31%
-119
- C1 -
-
2XKC
1
NEK2_HUMAN
A:
[3-270]
--------------------------------------------------------------------
S
R
A
E
D
--
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
------
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----------
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
----------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
K
F
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
63.82
31%
-123
- C1 -
-
2XK8
1
NEK2_HUMAN
A:
[3-270]
--------------------------------------------------------------------
S
R
A
E
D
--
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
------
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
-------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
----------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
K
F
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
63.34
31%
-66
- C1 -
-
5M51
1
NEK2_HUMAN
A:
[3-270]
--------------------------------------------------------------------
S
R
A
E
D
--
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
------
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
DG
G
H
T
V
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
--------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
-----
S
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
K
F
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.27
31%
-123
- C1 -
-
2XK7
1
NEK2_HUMAN
A:
[3-270]
--------------------------------------------------------------------
S
R
A
E
D
--
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
------
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
--------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
----------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
K
F
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
62.63
31%
-118
- C1 -
-
2XK3
1
NEK2_HUMAN
A:
[3-270]
--------------------------------------------------------------------
S
R
A
E
D
--
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
------
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
-------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
K
F
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
61.91
31%
-124
- C1 -
-
2WQO
1
NEK2_HUMAN
A:
[3-270]
--------------------------------------------------------------------
S
R
A
E
D
--
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
------
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
-----------
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
----------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
K
F
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
61.88
31%
-73
- C1 -
-
2XKD
1
NEK2_HUMAN
A:
[3-270]
--------------------------------------------------------------------
S
R
A
E
D
--
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
------
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D---------
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
------------------
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
-----
S
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
K
F
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------