@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_36_1590: (2018-03-13 )
MAAPSDALIKKVCNAFPATFGVDTEEDRSPAEGRLSRPFRYYLDTVLGSGTSGTVLYARRVRDDYPFAVKVMDVEGYTPQEIMRASGEVCCLLSCDYFSIVKCHEDFVYSDERNPESVSMMAMVLDYANAGDLRQEIKNRSKTNRPFAEHEAGLIFIQVLLAVHHVHSKRMIHRDIKSANILLCSNGLAKLGDFGFSKHYAATVSDDVGRTFCGTPYYVAPEIWRRRPYSKKADMFSLGVLLYELLTLKRPFDGEDIEEVMHKTLAGRFDPLPDSISKEMQTIVSALLQSEPKKRPSSKTLLNTPTCKLYISVVREIVQSGEASGFSVEQETTITRQLKQTKEELQVDRRRPPLSMEDVLRTTVKVPLSDSPDRIGFILYGGKVMKQSSDLSWKRRYVCVYGEVEKGCTLTGDVASCLVSLELVQAVSRDTLEQQCISTPFSDLEDVFPVISKYTGSDAAHAFAVAFKNGRRILFDADDDNDRDGWMRSIQSFLGIGDEDD
Atome Classification :
(20 SA)
.........10........20........30......----..40........50........60-...---.....70......-.------.80--.........90....-....100.......110.......120.......130.......140.......150.......160......-.170.......180..-.--.---.---.--.190.......200.......-210.......220...------..-.-.-230.......240.......250.......260.....--------------------------..----270-.---........280.......290....-----...300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAA
P
S
D
A
L
I
K
K
V
C
N
AFPATFGVDTEEDRSPAEGRLS
R
----
P
F
R
Y
Y
L
D
T
V
LGSGTS
G
T
V
L
Y
A
RRV-RDD---Y
P
F
A
V
K
V
M
DVEGY-
T
------
P
Q
---
E
I
M
RASG
E
V
C
C
L
LSC-
D
Y
F
S
I
V
K
CH
E
D
FVYSDERN
P
E
S
V
S
M
M
A
M
V
L
DYA
N
A
G
D
L
R
Q
E
I
K
NRSKTNRPFAEHE
A
G
L
I
F
I
Q
V
L
L
A
V
H
H
V
H
S
-
K
R
M
I
H
R
DIKSA
N
I
L
L
C-S--N---
G
---
L
--
A
K
LGDFGFSK
H
Y
A
A
TVSDDVG-RTFCGTPYYV
A
P
E
I
W
R------RR-P-Y-SKK
A
D
M
F
S
L
G
V
L
L
Y
E
L
L
T
LKRPF
D
G
E
D
I
E
E
V
M
H
K
T
LAG--------------------------RF----D---P---L
P
D
S
I
S
K
E
M
Q
T
I
V
S
A
L
L
QSEPKKRP-----SSK
T
L
LNTP
T
C
K
L
Y
I
S
V
V
R
E
I
V
QSGEASGFSV
E
Q
E
T
T
I
T
R
Q
L
K
Q
T
K
E
E
L
Q
VDRRRPPL
S
M
E
D
V
L
R
T
T
V
KVPLSDSP
D
R
I
G
F
I
L
YG
G
K
V
MKQSSDLS
W
K
R
R
Y
V
C
V
YGEVEKG
C
T
L
T
G
D
V
A
S
C
L
V
S
L
E
L
V
Q
A
V
S
R
D
T
L
E
Q
Q
C
IST
P
F
S
D
L
E
D
V
F
P
V
I
S
KYTGSDAA
H
A
F
A
V
A
FKNG
R
R
I
L
F
DADDDN
D
R
D
G
W
M
R
S
I
Q
S
F
LGIGDEDD
23
HHSearch
86.03
28%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[2-271]
------------------------------------
M
----
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
-
P
T
G
---
Q
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
------
A
R
---
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
--------
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
----
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
-
S
--
K
SKG
A
---
A
--
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
--
Q
A
W
-
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
-
P
-
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
--------------------------
A
Y
DFP-
S
---
P
---
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
85.07
30%
-123
- C1 -
-
2W5B
1
NEK2_HUMAN
A:
[4-274]
------------------------------------
R
----
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
-
S
D
G
---
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
------
E
A
---
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
------
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
-
L
H
R
D
L
K
P
A
N
V
F
L
D
-
G
--
K
---
Q
---
N
--
V
K
L
G
D
F
G
L
A
R
I
L
N
H
D
T
--
S
F
A
-
K
A
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
-
S
-
Y
-
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
--------------------------
K
F
----
R
---
R
---
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
77.05
29%
-109
- C1 -
-
5K00
1
MELK_HUMAN
A:
[6-266]
------------------------------------
L
----
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
-
L
T
G
---
E
M
V
A
I
K
I
M
D
K
N
T
L
--------
G
S
---
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
--------
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
----
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
-
E
--
Y
---
H
---
K
--
L
K
L
I
D
F
G
L
C
A
K
P
---------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
K
-
S
Y
L
-
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
--------------------------
K
Y
--------
D
---
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
77.03
28%
-65
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[9-274]
------------------------------------
F
----
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
-
T
T
G
---
L
E
F
A
A
K
I
I
N
T
K
K
L
-
S
------
A
R
---
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
--------
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
----
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
-
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
-
S
--
K
---
A
KG
A
A
--
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
E
---
A
W
-
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
D
-
P
-
Y
-
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
A
Q
I
K
A
G
--------------------------
A
Y
----
D
Y
P
S
P
---
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
-----
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.45
30%
-100
- C1 -
-
5ES1
1
MARK4_HUMAN
A:
[17-256]
--------------------------------------------
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
---
R
E
V
A
I
K
I
I
D
K
T
Q
L
-
N
------
P
S
---
S
L
Q
K
L
F
R
E
V
R
I
M
K
G
L
-
N
H
P
N
I
V
K
L
F
E
V
I
--------
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
S
H
G
R
----
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
-
K
N
I
V
H
R
D
L
K
A
E
N
L
L
L
D
-
A
--
E
---
A
---
N
--
I
K
I
A
D
F
G
F
S
N
-----------------
S
P
P
Y
A
A
P
E
L
F
Q
------
G
K
-
K
-
Y
D
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
H
N
L
K
E
L
R
E
R
V
L
R
G
--------------------------
K
Y
----
R
-------
V
P
F
Y
M
S
T
D
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
73.87
28%
-84
- C1 -
-
2QNJ
-
MARK3_HUMAN
A:
[56-302]
--------------------------------------------
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
---
R
E
V
A
I
K
I
I
D
K
T
Q
L
-
N
------
P
T
---
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
-
N
H
P
N
I
V
K
L
F
E
V
I
--------
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
----
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
D
-
A
--
D
---
M
---
N
--
I
K
I
A
D
F
G
F
S
N
E
F
T
-----
D
----
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
------
G
K
-
K
-
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
--------------------------
K
Y
----
R
-------
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
E
Q
I
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
72.59
22%
-23
- C1 -
-
1KOB
1
?
A:
[23-374]
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
--------------
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
-
A
T
G
---
R
V
F
V
A
K
F
I
N
T
P
Y
P
-
L
------
D
K
---
Y
T
V
K
N
E
I
S
I
M
N
Q
L
H
H
-
P
--
K
L
I
N
L
H
D
A
F
E
--------
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
---
A
A
E
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
-
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
-
T
--
K
KA-
S
---
S
--
V
K
I
I
D
F
G
L
A
T
K
L
N
---
P
D
E
I
V
-
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
E
-
P
-
V
-
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
--------------------------
D
W
----
E
F
DE
D
---
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
-----
T
V
H
D
A
L
E
H
P
-------------------------------
W
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
------------------------------------------
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
-------------------------------------------------------
31
HHSearch
72.37
30%
-12
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[92-364]
------------------------------------
F
----
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
-
A
T
G
---
H
E
F
A
V
K
I
M
E
V
T
A
E
-
R
LSPEQL
E
E
---
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
--------
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
----
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
-
D
--
N
---
M
---
Q
--
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
---
K
L
-
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
-
G
-
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
--------------------------
Q
Y
----
Q
---
F
SSP
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
71.09
28%
-50
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[21-293]
-----------------------------------
L
F
----
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
-
E
T
G
---
Q
Q
F
A
V
K
I
V
D
V
A
K
F
-
T
S
SP---
G
L
---
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
--------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
-
S
--
K
ENS
A
---
P
--
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
--
L
V
A
-
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
-
P
-
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
G
I
I
K
G
--------------------------
K
Y
----
K
M
N
P
R
---
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
70.65
31%
-66
- C1 -
-
2I0E
-
KPCB_HUMAN
A:
[27-265]
-------------------------------------------------
V
L
G
K
G
S
F
G
K
V
M
L
S
E
R
K
-
G
T
D
---
E
L
Y
A
V
K
I
L
K
-------------
K
---
D
V
V
I
Q
D
D
D
V
E
C
T
M
V
E
-
K
R
V
L
A
L
P
G
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
G
R
F
K
E
P
H
A
V
F
Y
A
A
----
E
I
A
I
G
L
F
F
L
Q
S
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
--
E
---
G
---
H
--
I
K
I
A
D
F
G
M
C
K
E
---
N
I
W
D
G
V
T
T
K
T
F
C
G
T
P
D
Y
I
A
P
E
I
I
A
------
Y
Q
-
P
-
Y
-
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
A
P
F
E
G
E
D
E
D
E
L
F
Q
S
I
M
E
H
--------------------------
N
V
--------
A
---
Y
P
K
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
70.47
28%
-68
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[3-270]
-----------------------------------------
Q
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
-
N
T
G
---
E
L
A
A
I
K
V
I
K
L
E
P
G
---------
E
---
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
--------
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
----
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
-
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
-
D
--
N
---
G
---
H
--
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A
------
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
ER---
K
G
-
G
-
Y
-
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
R
A
L
F
L
M
T
K
S
--------------------------
N
F
Q
P
P
K
L
---
K
---
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
-----
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
69.86
29%
0
- C- -
-
4PDP
-
?
B:
[193-472]
-----------------------------------
I
F
----
K
D
F
S
I
I
D
E
V
V
G
Q
---
A
T
V
K
K
A
I
E
R
-
T
T
G
---
K
T
F
S
V
K
I
I
S
K
------------------
D
G
V
T
R
E
L
E
V
L
Q
K
L
-
N
H
P
R
I
V
R
L
K
G
F
Y
E
D
----------
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
----
G
A
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
-
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
E
-
Q
--
D
---
D
---
P
V
L
V
K
I
T
A
F
G
L
A
K
V
Q
---------------
T
L
A
Y
V
A
P
E
V
I
---------N
E
-
Y
-
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
G
S
T
Q
D
Q
L
Y
K
Q
I
G
R
G
--------------------------
S
Y
----
H
---
E
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
-----
T
A
A
K
A
L
N
H
P
W
I
K
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
69.36
30%
-8
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[92-364]
------------------------------------
F
----
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
-
A
T
G
---
H
E
F
A
V
K
I
M
E
V
----
R
LSPEQL
E
E
---
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
--------
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
----
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
-
D
--
N
---
M
---
Q
--
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
---
K
L
-
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
-
G
-
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
--------------------------
Q
Y
----
Q
FSS
P
---
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
67.41
26%
-28
* C1 *
-
4GV1
5
AKT1_HUMAN
A:
[6-279]
------------------------------------
T
----
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
-
A
T
G
---
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
------
K
D
---
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
--------
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
----
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
--
D
---
G
---
H
--
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
-
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
------
D
N
-
D
-
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
--------------------------
E
I
--------
R
---
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
67.41
28%
-45
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[21-293]
-----------------------------------
L
F
----
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
-
E
T
G
---
Q
Q
F
A
V
K
I
V
D
V
A
K
F
-
T
S
SP---
G
L
---
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
--------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
-
S
--
K
ENS
A
---
P
--
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
--
L
V
A
-
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
-
P
-
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
G
I
I
K
G
--------------------------
K
Y
----
K
MNP
R
---
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
67.29
25%
-73
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[20-283]
------------------------------------
L
----
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
-
S
S
K
---
K
T
Y
M
A
K
F
V
K
V
K
G
T
-------------
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
--------
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
---
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
-
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
-
T
RR
S
---
S
---
T
--
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
---
N
F
-
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
-
V
-
V
-
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
--------------------------
E
Y
TFD-
E
---
E
---
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
-----
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
65.87
23%
0
- C- -
-
3EB0
3
?
A:
[6-348]
-----------------------------------------
S
K
K
Y
S
L
G
K
T
L
G
T
G
-
F
G
I
V
C
E
V
F
D
I
-
E
S
G
---
K
R
F
A
L
K
K
V
L
Q
D
P
R
----------------
Y
K
N
R
E
L
D
I
M
K
V
L
-
D
H
V
N
I
I
K
L
V
D
Y
F
Y
T
T
-------
N
K
Y
L
N
V
I
M
E
Y
V
P
-
D
T
L
H
K
V
L
K
S
F
I
R
S
G
R
S
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
-
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
N
S
K
--
D
---
N
---
T
--
L
K
L
C
D
F
G
S
A
K
K
L
I
P
S
---
E
P
S
-
V
A
Y
I
C
S
R
F
Y
R
A
P
E
L
M
L
------
G
A
T
E
-
Y
-
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
L
G
K
P
L
F
S
G
E
T
S
I
D
Q
L
V
R
I
I
Q
I
MGTP
T
K
E
Q
M
I
R
MNPHYVR
F
P
T
L
K
A
K
D
W
R
----
K
---
I
---
L
P
E
G
T
P
S
L
A
I
D
L
L
E
Q
I
L
R
Y
E
P
D
L
R
I
-----
N
P
Y
E
A
M
A
H
P
F
F
D
H
L
R
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
65.08
31%
3
- C1 -
-
4NW5
1
KS6A3_HUMAN
A:
[29-281]
-----------------------------------------
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
-
S
G
S
DAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
------
V
R
---
D
R
V
R
T
K
M
E
R
D
I
L
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
--------
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
----
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
--
E
---
G
---
H
--
I
K
L
T
D
F
G
L
S
K
--
E
S
I
D
H
E
K
K
A
-
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
------
R
R
-
G
-
H
-
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
--------------------------
K
L
----
G
-------
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
64.65
31%
-4
- C1 -
-
3IW4
-
KPCA_HUMAN
A:
[13-269]
----------------------------------
L
D
R
VKLT
D
F
N
F
L
M
--
V
L
G
K
G
S
F
G
K
V
M
L
A
D
R
K
-
G
T
E
---
E
L
Y
A
I
K
I
L
K
K
D
V
V
-
I
------
Q
D
DD
V
E
C
T
M
V
E
K
R
V
L
A
L
L
D
K
-
P
P
F
-
L
T
Q
L
H
S
C
F
--------
Q
T
V
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
G
K
----
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
K
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
--
E
---
G
---
H
--
I
K
I
A
D
F
G
M
C
K
E
H
--
M
M
D
G
V
T
T
-
R
E
F
C
G
T
P
D
Y
I
A
P
E
I
I
A
------
Y
Q
-
P
-
Y
-
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
Q
P
P
F
D
G
E
D
E
D
E
L
F
Q
S
I
M
E
H
--------------------------
N
V
----
S
-------
Y
P
K
S
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
64.52
32%
-21
- C1 -
-
2Z7Q
1
KS6A1_HUMAN
A:
[27-275]
-----------------------------------------
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
T
R
P
D
SG-
H
L
Y
A
M
K
V
L
----------------------------
I
L
A
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
--------
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
----
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
--
E
---
G
---
H
--
I
K
L
T
D
F
G
L
S
K
--
E
-------------
G
T
V
E
Y
M
A
P
E
V
V
N
------
R
Q
-
G
-
H
-
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
T
M
T
L
I
L
K
A
--------------------------
K
L
----
G
-------
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
-----
G
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------