@TOME V2.3
(Mar 2018)
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Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_36_2760: (2018-03-13 )
MTLNQFKSWPSKYPKSALEDTAPVRLRANSSTAASASPATAPATSTMPTSVLYSVLLRASVSRNAVSKNPAERSPHSHTVYDIDSTVREAVRAEVERLFPYRGAFAEPPGGADVDRATPAQRFFGLAPKAEEGERSGCRSACVARVNVYRHISEPDTHNPRAPVPSTTTAVAATETPSSSAARQTSTSVLQRLSGGPRVVIKSLKRKKTLAVMGATRVPAPSMPESAEAPKQLFAPLLAENSIGVGGVMRDQEASSCTSPSAVADNSHRFTVVSATELPDMQRHLERLFDDFAAAVEQCRAALDQQQLQSSSPAAWQTTKKKRGVASEEPSVSLLGEEASASQHPQQPPHCTNSNHRPGNSTVLSTDVLPRHNSHHPVSDFLSPDRIPDEWRHDHGTVATANGSCCTSYAQSASGESVRMADGSVPETTPSLEAEDFSTGIVMIAHTIAEHLHAILHPNITLAALEEEAAALRGQGHGGSSGAGGPAALNAVMATCRRSHTGAEGEDRKPMSPASFSSPSPLPDLRSSEGLQSPSGASSAPLGPRALRQLVHSLFWSRITAFLSSVSLKTPGKDCPMWLSTAAVEQREACSYVQLPFWIWLYAACGLATDVIRAQQEAQRDFTIPGQATGPRKTLTSSSATASAPPPPSLSQLLPTVETLARQLQRRQYERVDSTAGTLLTANTFLSFTGVQMTDKAVMKRLFPLQSGVIASDALGFATLSPHSAQCITHEASVATESSSGSLTTGAFDSAAVPTLISINTSSDRLISAEHTMSAFAGAGPNAIDRSSSSVEGAPISPSRRGQAATSVVLGDAGNTAAYATEEAPQVHSGSYSCPSTVELYLQWLESADAARLAACSSRSEAERFPDRADTEADAAGEVAASSPTSRPYRPGTIACMQPHVSSYAEDGQASNGDGNIARGNSSSGKDRSSSDSSFSYATVQRPSEPFRVAAVMPSAGLAPCLGRVEKELHQARSAVQFARKVGTLYATQDMKTLLQLLPAVAREEPVSPNANLVSARADGGAVESFGGAFPPRGGTDSTGTPAAPATPAEGVHSQYTWTGTPTTSNPMTGSLPPLVTPPQVAADRMPGNHALFFRRANASSTPPALFPSVTSPSLEKRLLMEHLDSCAAAIVSNSYELFVDSARALEVSFSLAVVLLSHVMGEAVPKGEVASVVQAAAVASSSDSSQSAISTKAGAVTTTMVVLKRLPAKVAAAALSEKSKGRVTTKTAAAPPPPRPLSMDLAKVFGFGRSRLWWQHLSAYVRETLISVALRALQRKDVAMTQELLQCITLDMTIAHHYDQVRRHHPVPKPARVKGVGDTKKVSGSTLKKSRSAFKAGGRKVTHLSAPPHESSASFVNVWLSSFAHLADTTTHLLHGDHNAPSSLKGAVWHLAGLAHYFLLTRARGYDMYGGQSHLCSTTLFGHGSGNSAGVGVRTSSVTSSAALQSFITSQLVEPAGKVLGVVVSFMESVCQALSADIESGGAAERHFREGVMFVDNSSDDESLFMCPAADDSVRLGSAAESTSLYSDGGGGDYDMASNRLETSGLQTCWMELAIHYFFEIVDVLLDAALHLPEKPLYLYQLTVSAFNTAAPSIDFADTLSAAVLAGGAGSPLLWGLGDLSSSVVATAPQVVADSPLDRVQEFLSTYTSMVLQSAVNHFTVDSRHAHSRVATARETPLNTSAAADGTSEDDWPRTFWERLLTSVAAPANPSALGEVILTARQPLPSASTPTSWPAANPAVSPEVSASSSYTRSTMWWPDVRFHRYSHLIRIVEHAQLVSLYLNSCAGSNPAQTAPLTSYLEVSRAPRDSAPSLQVSAVTSLLNTSTGPCAQLLSIPYACPPSAVDTSSSSIIPGSARTTSHERCWFHCTGSPADQSPPRFPAGAHRRVPADRAMREVCGGLWIRVELLRLLRLAAAPLDAETFVSFTKTASKVATQTRDRAMQTHYTAIASMKAGAESVLPKTYASTYVRLLFLRYVQAFYADVHALSASGPATGPDHTTSERVDGTSNATPLTRSVDQRAALATHADLSSHGDATPYRTLGPPQMRSQVSTLQHLSQRLWTHYCHELLWALRELCWSCAEAHETAANLSVASVFGRLLQMISGRGELEGDDVIDDYDDEPAEKFPDEPHLDLKDVGMSFITSERALEPYSTAEGVRMEGFVDFEVSSSDSSVTVVPGMSEGRKRPPGQPPNSGSSDDFERRLEPSRSARRSPVSKASVEVEQQVMVGISDQASVFDFKERRRLGSNDHFISGGTQATVRSTTPLAASNTPVPTPPRTPVTAPPVVQKLSFTGLKPPLYFTSSGDTAAAQENDFYKEQSKQPQMAKEPMVHFLSTTGMSVVDAASHQSQDDDNGECDVKYEARSDALESASKHTLPKSTSHEPRESYSTANANADSATRRDAPKPPALTIPKLSLGALSPPLYFTSTGDTAVFAERPISPSLARPPAQAFPTLNSLTAAAPAVVGAAHVDPAVRGAPLKGAAEAANASTLTPPPAPVLHTSTPTTVDGFALPKLSFGSLGPPMYFTSTGDTGGFIEAENQKPHAVAGATTSAQIPSDTIHLQFGLTAQGMASRGTANTATATAAAITASNCPTAATAAAHFHGSHSSDESHLRPVFSFADFAPTGGKVSRSGNASDEVGSYAGCVDEQDSKERRRCDSALSLNSLPMPESSPLSMLTGQRRRKRVPRTSRPVLTPIVAPAVTMELILCICSIILQQDSGMIQYAYTVSSLTQKRVLPDMSSSSQRRWHAGSGTAAAASGSTFTQKSDAAQTDRWRYTPQHSPSSFHVIQAMHNYLKDSRNSLVIDLLEEWVLDEYAEMERARMEQFESAYAPSMQQECSPQPPHPSYSHNESGGNIGNSVHHHSLHQPQAGGTGGGRSGKPSAAMLAGRYVLLRLLLPRAITPLITQQNERRIGAGGYGSVTSGFVQRPGTGGDTQLPPGWGQRGFRWRPAKTRGSTAASGSGAGVGGTTPQSLHMGRSVTTTAERIAPGVLDGLRAPWRTATQRIAQAVCKCEVAIKHIPLNVQGSESGNLPLCHAEVLCMYRLRGHPHIVPLLSFDNTKDEYILVLPHYTQGSLRLWRQKHYPLGCAVLTLSPGMKDSCKSGPMPTAAPATTSSTPTPAAAPSTSLFTTCARCLLQVLKGVAFMHDHRIRHGDIKCDNVLITATAASAARGEMDPPMLPSSVCLCDFGSCDTCDDDDIQNLKHDIMAGEARFLAGRWGVGRGTEAIQPPELMSAKRRYALLRRIATAVAPAAAATPATSSLLTLSERVERGSHAASFAGPSAEYLPLRSRGGELMESTGPQMTELLRRAELSVDIWACGCLLYEMLTGRMLFGEARLGRLLVLAAVDDGEDQDPETAASKTSTAAGPLPGAPRSLQKATVPTTSSVGADTGSSFTPSVSKKALDDWERRDLEAAVGKRVVDFMSTLLDLDPLQRPSAHEALQHWKTIMVEAGLEI
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350......2360......2370......2380......2390......2400......2410......2420......2430......2440......2450......2460......2470......2480......2490......2500......2510......2520......2530......2540......2550......2560......2570......2580......2590......2600......2610......2620......2630......2640......2650......2660......2670......2680......2690......2700......2710......2720......2730......2740......2750......2760......2770......2780......2790......2800......2810......2820......2830......2840......2850......2860......2870......2880......2890......2900......2910......2920......2930......2940......2950......2960......2970......2980......2990......3000......3010......3020....----.----.3030......3040......3050......3060------.......3070......3080......3090......3100......3110......3120......3130......3140......3150......3160......3170......3180......3190......3200..--....3210......3220...-...3230......3240......3250...----...3260......3270......3280......3290......3300......3310......3320......3330.......3340...-...3350......3360......3370......3380......3390......3400......3410......3420......3430......3440...-...3450.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
L
N
Q
F
K
S
W
P
S
KY
P
K
S
A
LEDTA
P
V
R
L
R
ANSSTAASASPATAPATSTM
P
T
S
V
L
Y
S
V
L
L
R
A
S
VSRNAVSKNPAERSPHS
H
T
V
YD
I
D
S
T
V
R
E
A
V
R
A
E
V
E
R
LFPYRGAFAEPPGGADVDRAT
P
A
Q
R
F
FGLAPKAEEG
E
R
S
G
C
R
S
A
C
V
A
R
V
N
V
Y
R
HISEPDTHNPRAPVPST
T
T
A
V
A
ATETPSSSAAR
Q
T
S
T
S
V
L
Q
R
LSGG
P
R
V
V
I
K
S
L
KRK
K
T
L
A
V
MGATRVPAPSMPESAE
A
P
K
Q
L
F
A
P
L
L
AENSIGVG
G
V
MRDQEASSCTSPSAVADNSH
R
F
T
V
V
S
A
TE
L
P
D
M
Q
R
H
L
E
R
L
F
D
D
F
A
A
A
V
E
Q
C
R
A
A
L
D
Q
Q
Q
L
QSSSPAA
W
Q
T
T
K
KKRGVASEEP
S
V
S
L
LGEEASASQHPQQPPHCTNSNHRPGN
S
T
V
L
STDVLPRHNSHHP
V
S
D
FLSPDRI
P
D
E
WRHDHG
T
V
ATAN
G
S
C
C
T
S
Y
A
QSASG
E
S
V
R
MADGSVPETTPSLE
A
E
DFST
G
I
V
M
I
A
H
T
I
A
E
H
L
H
A
I
LHPN
I
T
L
A
A
L
E
E
E
A
A
A
LRGQGHGGSSGAG
G
P
A
A
L
N
A
V
M
A
T
C
R
RSHTGAEGEDRKPMSPASFSSPSPLPDLRSSEGLQSPSGASSAPL
G
P
R
A
L
R
Q
L
V
H
S
L
F
W
S
R
I
T
A
F
L
S
SVSLKTPGKDCP
M
W
L
S
T
A
A
V
E
Q
R
E
ACSYVQ
L
P
F
W
I
W
L
Y
A
A
C
G
L
A
T
D
V
I
R
A
Q
Q
E
A
QRDFTIPGQATGPRKTLTSSSATASAPPPP
S
L
S
Q
L
L
P
T
V
E
T
L
A
R
Q
L
Q
R
R
Q
Y
E
R
VDSTA
G
T
L
L
T
AN
T
F
L
S
FTGVQM
T
D
K
A
V
M
K
R
L
F
P
LQSGVIASDAL
G
F
ATLSPHS
A
Q
C
I
THEASVATESSSGSLTTGAFDSAAV
P
T
L
I
S
I
NTSS
D
R
L
I
S
A
E
H
T
M
S
A
FAGAGPNAIDRSSSSVEGAPISPSRRGQ
A
A
T
S
V
V
LGDAGNTAAYATEEAPQVHSGSYSC
P
S
T
V
E
L
Y
L
Q
W
L
E
SA
D
A
A
R
L
A
ACSS
R
S
E
A
E
RFPDRADTEADAAGEVAASSPTSRPYRPG
T
I
A
C
M
Q
P
H
V
S
S
Y
AEDGQASNGDGNIARGNSSSGKDRSSSDSS
F
S
Y
A
TVQRPSEP
F
R
V
A
A
VMPSAG
L
A
P
C
L
G
R
V
E
K
E
L
H
Q
A
R
S
A
V
Q
F
A
R
K
V
G
T
LY
A
T
Q
D
M
K
T
L
L
Q
L
L
P
A
V
AREEPVSPNA
N
L
V
S
ARADGGA
V
E
SFGGAFPPRGGTDSTGTPAAPATPAEGVHS
Q
Y
T
WTGTPTTSNPMTGSLPPLVTPP
Q
V
A
A
DRMPGN
H
A
L
F
F
R
RANASSTPPALFPSVTS
P
S
L
E
K
R
L
L
M
E
H
L
D
S
C
A
A
A
I
V
SNS
Y
E
L
F
VDSA
R
A
L
E
V
S
F
S
L
A
V
V
L
L
S
H
V
M
GEAVP
K
G
E
V
A
S
V
V
Q
A
A
AVASSSDSSQSAISTKAG
A
V
T
T
T
M
V
V
L
K
RL
P
A
K
V
A
A
A
A
LSEKSKG
R
V
TTKTAAAPPPPR
P
L
S
M
D
L
A
K
V
FGFG
R
S
R
L
W
W
Q
H
L
S
A
Y
V
R
E
T
L
I
S
V
A
L
R
A
L
Q
R
K
D
V
A
M
T
Q
E
L
L
Q
C
I
T
L
D
M
T
I
A
H
H
Y
D
Q
V
R
RHHPVPKPARVKGVGDTKKVSG
S
T
L
K
K
S
R
S
A
F
K
AGG
R
K
V
T
H
LSAPPHESS
A
S
F
V
N
V
W
L
S
S
F
A
H
L
A
D
T
T
T
H
LLHGDHNA
P
S
S
L
K
G
A
V
W
H
L
A
G
L
A
H
Y
F
L
L
TRARGYDMYGGQS
H
L
C
S
T
T
L
F
GHGSGNSA
G
V
G
V
R
TSSV
T
S
S
A
A
L
Q
S
F
I
T
S
Q
L
V
E
P
A
G
K
V
L
G
V
V
V
S
F
M
E
S
V
C
Q
A
L
S
A
D
I
ESGG
A
A
E
R
H
FRE
G
V
M
F
VDNSSDDE
S
L
F
MCPAADDSVRLGSAAES
T
S
LYSDGGGGDYDMASNR
L
E
TS
G
L
Q
T
C
W
M
E
L
A
I
H
Y
F
F
E
I
V
D
V
L
L
D
A
A
LHLPEK
P
L
Y
L
Y
Q
L
T
V
S
A
FNTAAPSI
D
F
A
D
T
L
S
A
A
V
LAGGAGSP
L
L
W
G
L
G
D
LS
S
S
V
V
ATA
P
Q
VVADS
P
L
D
R
V
Q
E
F
L
S
T
Y
T
S
M
V
L
Q
S
A
V
N
H
F
TVDSRHAHSRVATARETPLNTSAAADGTSED
D
W
P
R
T
F
W
E
R
L
L
T
S
VAAPA
N
P
S
A
L
G
E
V
I
L
TARQPLPSASTPTSWPAANPAVSPEVSASSSYTRSTMWWPDV
R
F
H
R
Y
S
H
L
I
R
I
V
E
H
A
Q
L
V
S
L
Y
L
N
SCAGSNPAQTAP
L
T
S
Y
L
E
VSRAPRDSAPS
L
Q
V
S
A
V
T
S
L
L
NTST
G
P
C
A
Q
L
LSIPYACPPSAVDTSSSSIIPGSARTTSHE
R
C
W
F
H
CTGSPADQSPPRFPAGAHRRV
P
A
D
R
A
M
R
E
V
CG
G
L
W
I
R
V
E
L
L
R
L
L
R
L
AAAPL
D
A
E
T
F
V
S
F
T
K
T
A
S
K
V
A
T
Q
T
R
D
R
A
M
Q
T
H
Y
T
A
I
A
S
M
KA
G
A
E
S
V
L
P
K
T
Y
A
S
T
Y
V
R
L
L
F
L
R
Y
V
Q
A
F
Y
A
D
V
H
ALSASGPATGPDHTTSERVDGTSNATPL
T
R
S
V
D
Q
R
A
A
L
ATHADLSSHGDATPYRTLG
P
P
Q
M
R
S
Q
V
S
T
L
Q
H
L
S
Q
R
L
W
T
H
Y
C
H
E
L
L
W
A
L
R
E
L
C
W
S
C
A
E
A
H
E
T
AAN
L
S
V
A
S
V
F
G
R
L
L
Q
M
ISGRGELEGDDVIDDYDD
E
P
A
EKFPDEPHL
D
L
K
D
V
G
M
S
F
I
T
S
ERALEPYSTAEG
V
R
M
E
G
F
V
D
F
E
VSSSDS
S
V
T
VVPGMSEGRKRPPGQPPNSGS
S
D
D
F
E
R
RLEPSRSARRSPVSK
A
S
V
E
V
E
Q
Q
V
M
VGISDQ
A
S
V
F
D
F
K
E
R
RRLGSND
H
F
ISGG
T
Q
A
T
V
RSTTPLAASNTPVPTPPRTPVTA
P
P
V
V
Q
K
LSFTGLKP
P
L
Y
F
TSSGDTAAAQEN
D
F
Y
K
E
QSKQP
Q
M
A
K
E
P
M
V
H
F
L
STTG
M
S
V
VDAASHQSQDDDNGE
C
D
V
K
Y
EAR
S
D
A
L
E
S
A
SKHTLPKSTSHEPRESYSTANANADSATRRDAPKPPA
L
T
I
P
K
LSLGALSP
P
L
Y
F
TSTGD
T
A
V
F
AERPISPSLARPP
A
Q
AFP
T
L
N
S
L
T
A
AA
P
A
VVGAAHVDPAVRGAPLKGAAEAANASTLTPPPAPVLHTSTPTTVDGFALPKLSFGSLGP
P
M
Y
F
TSTGDTGG
F
I
EAENQKP
H
A
VAGATTSAQIPS
D
T
I
H
L
Q
FGLTAQGMASRGTANTA
T
A
T
A
A
A
I
TASNCPTAA
T
A
A
A
H
FHGSHSS
D
E
S
H
L
R
P
V
F
S
FADFAPTGGKVSRSGNASDEVGSYAGCVDEQ
D
S
K
E
R
R
RCDSALSLNSLPMPESS
P
L
S
M
L
T
G
Q
R
R
R
KRVPRTSRPVLTPIV
A
P
A
V
T
M
E
L
I
L
C
I
C
S
I
I
L
QQDS
G
M
I
Q
Y
A
Y
T
V
S
S
L
T
Q
K
RVLPDMSSSSQ
R
R
WHAGSGTAAAASGSTFTQKSDAAQTD
R
W
R
YTPQHSPS
S
F
H
V
I
Q
A
M
H
N
Y
L
K
DSRN
S
L
V
I
D
L
L
E
E
W
V
L
D
E
Y
A
E
M
E
R
A
R
M
E
Q
F
E
S
AYAP
S
M
Q
QECSPQPPHPSYSHNESGGNIGNSVHHHSLHQPQAGGTGGGRSGK
P
S
A
A
M
L
A
G
R
Y
V
L
L
R
L
L
L
P
R
AI
T
P
L
ITQQNERRIGAGGYGSVTS
G
F
VQRPGTGGDTQLPPGWGQRG
F
R
WRPAKTRGSTAASGSGAGVGGTTP
Q
S
LHMGRSV
T
T
T
A
E
R
I
A
P
G
V
L
D
GLRA
P
W
R
T
A
T
Q
R
I
A
Q
A
V
C
K
C
E
V
A
I
K
HI
P
L
N
V
QG----S----ESGNLP
L
C
H
A
E
V
L
C
M
Y
R
LRGHP
H
I
V
P
L
LSFDNT-K------D
E
Y
I
L
V
LPHYTQ
G
S
L
R
L
W
R
QKHYPL
G
C
A
V
L
T
LSPGMKDSCKSGPMPTAAPATTSSTPTPAAAPS
T
S
L
F
T
T
C
A
R
C
L
L
Q
V
L
K
G
V
A
F
M
H
DHRIRHGD
I
K
CD
N
V
L
I
T
A
TAASAARGEMDPPMLPS
S
V
C
L
CDFGSCDTCD
D
D
D
I
Q
N
L
K
--
H
D
I
MAGE
A
R
F
L
AGRWGVGRGT-EAIQ
P
P
E
L
M
S
A
K
R
R
Y
A
L
L
R
R
I
A
T
A
VAPAAA----ATPA
T
S
S
L
L
T
L
S
E
R
V
E
RGSHAASFAGPSA
E
Y
L
P
L
R
SRG
G
E
L
M
E
STG
P
Q
M
T
E
L
L
R
R
AELS
V
D
I
W
A
C
G
C
L
L
Y
E
M
LT-G
R
M
L
FGEARL
G
R
L
L
V
L
-
A
A
VDDGEDQDPETAASKTSTAAGPLPGAPRSLQKATVPTTSSVGADTGSSFTP
S
V
S
K
K
A
L
D
D
W
E
R
R
D
L
E
A
A
V
G
K
R
V
V
D
F
M
S
T
L
LDLDPLQRP
S
A
H
E
A
L
Q
H
-
W
K
T
I
M
V
EAGLEI
38
HHSearch
85.27
27%
-143
- C2 -
-
2WEL
7
KCC2D_HUMAN
A:
[31-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
A
A
K
I
I
N
T
K
K
L
S
----------
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
-
E
------
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--------------------
Y
Y
S
---------------------
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
------------
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
-------------------
A
W
F
G
F
A
G
T
-
P
G
Y
L
S
P
E
V
L
R
K
D
----------------------------------------------------------------------------
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
-
I
K
--------------
A
G
A
-----
Y
D
-------------------------------------
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----------
22
HHSearch
82.34
27%
-143
- C2 -
-
4G3F
1
A:
[85-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
C
A
V
K
K
V
R
L
E
V
-----------------
F
R
V
E
E
L
V
A
C
A
G
L
S
-
S
P
R
I
V
P
L
Y
G
A
V
R
E
-
G
------
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
G
--------------------
C
L
P
---------------------
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
--------------
R
A
A
L
C
D
F
G
H
A
L
C
L
--------------------------
D
Y
I
P
G
T
-
E
T
H
M
A
P
E
V
V
M
G
K
----------------------------------------------------------------------------
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
Q
Y
F
R
G
P
L
C
L
K
-
I
A
--------------
S
-----
E
P
P
--------------------------------------
P
I
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
-
V
G
K
A
L
Q
E
V
G
---
23
HHSearch
80.86
26%
-130
- C2 -
-
4IDV
1
M3K14_HUMAN
A:
[101-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
C
A
V
K
K
V
R
L
E
V
F
-----------------
R
A
E
E
L
M
A
C
A
G
L
T
-
S
P
R
I
V
P
L
Y
G
A
V
R
E
-
G
------
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
G
--------------------
C
L
P
---------------------
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
--------------
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
P
D
G
L
G
K
S
L
--------------
L
T
G
D
Y
I
P
G
T
-
E
T
H
M
A
P
E
V
V
L
G
R
S
----------------------------------------------------------------------------
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
Q
F
F
R
G
P
L
C
L
K
-
I
A
--------------
S
-----
E
P
P
--------------------------------------
P
V
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
-
V
N
R
A
L
Q
Q
V
G
---
30
HHSearch
80.24
23%
-76
- C2 -
-
3C0G
1
CSKP_HUMAN
B:
[51-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
---
S
----
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
-
D
------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
----------------
G
F
V
Y
S
---------------------
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
------------
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
-------------------
V
A
G
G
R
V
G
T
-
P
H
F
M
A
P
E
V
V
K
R
E
P
----------------------------------------------------------------------------
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
C
L
P
F
Y
G
T
K
E
R
L
F
E
G
I
-
I
K
--
G
-------------
K
-----
Y
K
-------------------------------------
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
---------
31
HHSearch
80.06
23%
-77
- C2 -
-
3C0I
1
CSKP_HUMAN
A:
[51-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
---
S
----
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
-
D
------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
----------------
G
F
V
Y
S
---------------------
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
------------
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
-------------------
V
A
G
G
R
V
G
T
-
P
H
F
M
A
P
E
V
V
K
R
E
----------------------------------------------------------------------------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
C
L
P
F
Y
G
T
K
E
R
L
F
E
G
I
-
I
K
--
G
-------------
K
-----
Y
K
-------------------------------------
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
---------
43
HHSearch
79.55
19%
-131
- C2 -
-
2QOC
2
A:
[46-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
A
I
K
T
L
K
V
G
Y
T
-----------
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
-
H
P
N
I
I
R
L
E
G
V
V
T
K
-
S
------
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
-------------------
A
Q
F
T
---------------------
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
---------------
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
---------------------------
K
I
P
-
I
R
W
T
S
P
E
A
I
A
Y
R
----------------------------------------------------------------------------
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
-
V
D
--------------
E
---------------------------------------------
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
-
L
D
K
L
I
R
N
-----
41
HHSearch
79.02
19%
-129
- C2 -
-
5T18
1
A:
[34-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
A
I
K
M
I
K
E
G
S
M
-------------
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
-
Q
------
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-----------------------
F
Q
---------------------
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---------------
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
------------------
S
S
V
G
S
K
F
P
-
V
R
W
S
P
P
E
V
L
M
Y
S
K
----------------------------------------------------------------------------
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
-
I
A
--------------
Q
G
---------------------------------------------
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
-
I
L
D
V
M
D
E
-----
45
Fugue
78.35
19%
-54
- C2 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
-
Q
C
A
V
K
K
V
R
L
E
V
F
------------------
R
A
E
E
L
M
A
C
A
G
L
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
-
G
------
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
--------------------
G
C
L
P
---------------------
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
--------------
S
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
L
G
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
F
F
R
G
P
L
C
L
K
I
A
S
E
P
P
P
V
R
E
IPPS
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
-------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
77.76
24%
-34
- C2 -
-
2Y7J
1
PHKG2_HUMAN
C:
[121-364]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
A
V
K
I
M
E
V
T
A
E
R
----
L
SPEQ
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
-
S
------
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
--------------------
A
L
S
---------------------
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
M
---------------
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
K
--------------------
L
R
E
L
C
G
T
-
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
----------------------------------------------------------------------
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
-
I
M
--
E
-----------------
G
Q
Y
Q
---------------------------------
F
----
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
---------
21
HHSearch
76.73
21%
-112
- C2 -
-
2PSQ
-
B:
[113-368]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
T
V
A
V
K
M
L
K
D
D
A
T
-----------
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
--------------------
E
--------
E
--------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
---------------
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-----------------
K
K
T
T
N
G
R
L
P
-
V
K
W
M
A
P
E
A
L
F
D
R
V
----------------------------------------------------------------------------
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
-
L
K
--------------
E
---------------------------------------------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
-
L
D
R
I
L
T
L
T
T
N
--
39
HHSearch
76.64
24%
-28
- C2 -
-
1J1B
1
GSK3B_HUMAN
B:
[81-341]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
A
I
K
K
V
L
Q
D
K
----------------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
-
H
C
N
I
V
R
L
R
Y
F
F
Y
S
-
S
GEKKD
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
-----------------
K
Q
T
L
P
---------------------
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
--------------
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
--------------------
N
V
S
Y
I
C
S
-
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
---------------------------------------------------------------------------
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
---
Q
I
R
E
M
----------------------
N
P
N
---
Y
T
E
F
K
F
P
Q
I
---
K
A
H
P
W
-
T
K
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
---------
37
HHSearch
76.37
24%
-27
- C2 -
-
2Y7J
1
PHKG2_HUMAN
D:
[121-364]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
A
V
K
I
M
E
V
---
R
LSPE
Q
----
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
-
S
------
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
--------------------
A
L
S
---------------------
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
M
---------------
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
K
--------------------
L
R
E
L
C
G
T
-
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
----------------------------------------------------------------------
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
-
I
M
--
E
-----------------
G
Q
Y
Q
---------------------------------
F
----
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
---------
42
HHSearch
75.68
23%
-114
* C2 *
-
4Y85
1
M3K8_HUMAN
B:
[100-326]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
A
C
K
L
I
P
V
D
Q
F
-----------------
K
P
S
D
V
E
I
Q
A
C
F
R
-
H
E
N
I
A
E
L
Y
G
A
V
L
W
-
G
------
E
T
V
H
L
F
M
E
A
G
E
G
G
S
V
L
E
K
L
E
S
C
G
--------------------
P
M
R
---------------------
E
F
E
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
K
K
V
I
H
H
D
I
K
P
S
N
I
V
F
M
S
T
----------------
K
A
V
L
V
D
F
G
L
S
V
Q
M
T
E
D
V
Y
-------------------
F
P
K
D
L
R
G
T
-
E
I
Y
M
S
P
E
V
I
L
C
R
G
----------------------------------------------------------------------------
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
-
G
T
P
P
W
V
K
R
Y
P
R
S
A
Y
P
S
-
Y
L
Y
----------
I
I
H
K
Q
-------------------------------------------
A
P
P
L
E
D
I
A
D
D
C
S
P
G
M
R
E
L
I
E
A
S
L
E
R
N
P
N
H
R
P
R
A
A
D
L
L
K
H
E
A
L
N
---------
29
HHSearch
75.07
19%
-142
- C2 -
-
1TKI
-
TITIN_HUMAN
A:
[49-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
M
A
K
F
V
K
V
K
G
-------------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
R
-
H
R
N
I
L
H
L
H
E
S
F
E
S
-
M
------
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
-------------------
F
E
L
N
---------------------
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
R
S
-------------
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
N
--------------------
F
R
L
L
F
T
A
-
P
E
Y
Y
A
P
E
V
H
Q
H
D
V
----------------------------------------------------------------------------
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
-
I
M
--------------
N
A
E
-----
Y
T
-------------------------------------
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
-------------
26
HHSearch
74.90
23%
-149
- C2 -
-
2X4F
4
MYLK4_HUMAN
A:
[116-346]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
A
A
K
I
I
K
T
R
G
M
------------
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
D
-
H
A
N
L
I
Q
L
Y
D
A
F
E
S
-
K
------
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
-------------------
Y
N
L
T
---------------------
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
A
-------------
K
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
K
--------------------
L
K
V
N
F
G
T
-
P
E
F
L
A
P
E
V
V
N
Y
D
F
----------------------------------------------------------------------------
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
-
G
L
S
P
F
L
G
D
N
D
A
E
T
L
N
N
-
I
L
-------------
A
C
-
R
-----
W
D
---------------------------------
L
E
----
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
----------
44
HHSearch
74.73
23%
-14
- C2 -
-
2X0G
-
DAPK1_HUMAN
A:
[38-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
A
A
K
F
I
K
K
R
R
T
K
----
S
SR--
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
-
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
--------------------
L
T
---------------------
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
-----------
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
--------------------
F
K
N
I
F
G
T
-
P
E
F
V
A
P
E
I
V
N
Y
E
----------------------------------------------------------------------------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
-
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
-
V
S
--------------
A
V
N
------
Y
----
E
--------------------------------
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----------
35
HHSearch
74.04
25%
-145
- C2 -
-
4NIF
-
KS6A1_HUMAN
A:
[35-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
A
V
K
V
I
D
K
S
K
----------------
R
D
P
S
E
E
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
-
G
------
K
H
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
L
R
Q
K
--------------------
F
F
S
---------------------
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
-----------
N
P
E
C
L
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
N
G
-------------------
L
L
M
T
P
C
Y
----
F
V
A
P
E
V
L
K
R
Q
G
----------------------------------------------------------------------------
Y
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
-
G
Y
T
P
F
A
N
G
P
S
D
T
P
E
E
I
-
L
T
R
-----------
I
G
S
-----
G
K
F
T
---------------------------------
L
----
S
G
G
N
W
N
T
V
S
E
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
K
Q
V
L
Q
H
P
W
V
----------
32
HHSearch
72.09
19%
-108
- C2 -
-
3BKB
7
A:
[141-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
A
V
K
S
C
R
E
T
L
P
-----------
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
-
H
P
N
I
V
R
L
I
G
V
C
T
Q
-
K
------
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
-------------------
A
R
L
R
---------------------
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
---------------
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
-----------------
A
S
G
G
L
R
Q
V
P
-
V
K
W
T
A
P
E
A
L
N
Y
G
R
----------------------------------------------------------------------------
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
-
V
E
--------------
K
---------------------------------------------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
-
L
Q
S
I
R
K
R
-----
40
HHSearch
71.23
18%
-56
- C2 -
-
4ASE
1
A:
[94-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
R
T
V
A
V
K
M
L
K
E
G
A
T
-----------
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
------
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
-
P
-------------
Y
---------------
Y
---
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
---------------
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
-----------------
V
R
K
G
D
A
R
L
P
-
L
K
W
M
A
P
E
T
I
F
D
R
V
----------------------------------------------------------------------------
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
-
R
-------------
L
K
E
---------------------------------------------
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
-
L
G
N
L
L
Q
A
N
A
---
33
HHSearch
71.00
19%
-109
- C2 -
-
3CBL
2
A:
[141-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
A
V
K
S
C
R
E
T
L
P
-----------
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
-
H
P
N
I
V
R
L
I
G
V
C
T
Q
-
K
------
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
-------------------
A
R
L
R
---------------------
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
---------------
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
-----------------
A
S
G
G
L
R
Q
V
P
-
V
K
W
T
A
P
E
A
L
N
Y
G
R
----------------------------------------------------------------------------
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
-
V
E
--------------
K
---------------------------------------------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
-
L
Q
S
I
R
K
R
-----