@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_36_3090: (2018-03-13 )
MDEVINVISKCITQLNLFVDGPAAHLSGTAAPTTIETIRKCIADHAYLFTDHRINGQRMWELVCSATFTVGEPRTPTTAATATATLLSLFRRLTDSVAASARAPEADILKHLVKLLRDAVKPPLVRGASPGQLRCLFQAAMRLLKLLLPLKKRADVQTECLHLLLALMQLSDLQEAHCAVVASGDEVAQVAKLCADICGAKHDVALRPQNASMQLLGCLCEQPAYVHALSGQLAERILKCFLDVARNLAQRAEVNQTLGEGLLRGLAGVLGSFPLRCEEDAPALTLINNIVLSALMLGETSTNYTFCLSALFLLRRRASDTLAPFTLLCAAEYSVALRSLWMHRNKDVRRETHAAAAVFWSALSSQLQQRCSSEVADANTTRNTAASHKLHSIVEFLLRSLDSSADPEASYALEALYHLLPAVAALSGPQALQTMSTRLEERVGGLLITASAQRTEALFQQVPYLLATLGQLLTLLPSVSPRQQAVVRELLDWVLLLYPHPKFYNREKTVPGIVLVIRALTHHPRAPHNTLPRLLSERTLELVGEAPGAAMMRLAGERISTEERLDRMATLWTRLLTTREESGAEAEAESKQRLSAAFYRACTGFCERARLEVIVKSNSEATLERILVDGVDGVQPSFPTHYSAFLSFVDFFVRLSEGLKGSGGVCRPPAEELTAWLEALVRGASAALHVSGFYTLLHRTVVGVEGVCPHSLTHQRPYTDASLASGNSDVTSDGHHENHLCVSPLLRHFLSTECLRRVHVYSDELLYQCAMCVVVGAALVGSEDRGELAGSRARACDDHRRLDAYVRAFKVVMTATPTSLQAESVAGSTNEVVCSFGSSPAILESNRQHALRVLEKKACRSPRWAAAVLPALTSALRSAEVVAAVRAPVQMLAARHGVAIAAELQHHSNEATFALLCRGEPASNGRRDSMPRWLATMQPVTVPLVPVDSALHIGYLVPLVSRLSLYGKHPAVRTAAAEVLYWCVVWVIGKKVNDWGSAVFPPLLSLASLARTSTGGSGGGGGSMVHQELHGLLMQAARWFGRSAGTPEEAELFVSVLLRGLGEREGTQRQVATEALFAYAIPPADEPQTVTPHFRAVIGRLVRMECGVSEWSRLGAAHCLHVMMRRLCKVRVPGLVCTVQAVAQGAVGCLRRCTEAPIWGAMETATCNEVQESLRWLGAYCHDIRQLENEEEQREADRFAADLVHAARAVLPALARRHTVCAITLLQTLPAVTHTNASARQVLLLSQELICEQQQRLGPAAVRSLDSTVGGCATLVALLQSGYGTETNKRAIAEAVTPVICTRADDCSVETELLRLLTVVLQAIVEEARVATHESRCISPHIVRWLLELVDVVPEQTHATHFSLLLTPTVIAQAARVMVAGAKVTVENCAGDVGEDATAGVPLRRCAPSSQLAPTARWCLELIEFLMRVAGQRRRGAQVIEDVLCAIRETSVFTVFTAASPARQLIDALSVGPSALVTGPVALAAALCQMEAPCSSGTTTLWMRIADSMKISPKTVVAMLLGLLRNSAALNATGGEEVCEGLLVLMLSEPDPALLRQHLRDLLASDAVQHNIFTSSSFAVSLEDGHGAVAVSPSSRSTSVLLSRAFDSVMNRCWQQASAALPTDRLVSALPSLTTVAMSEDALRSSSEAVSLFSLVGDWLAELQRRSLTSEHDKVLCRVCANLVAAEREMRQSTPTAAQDDGRGGARLAALLMLVQLIGPAIRTDTTLSSALCDLVLFVSKPANMCSLLASVDATEHVVWGFHVLAATMTPRPARRSLAVFPVDLRAVEMAFDFLNEVLNSALPLRWTELKTPREKTNGADVVRSGTALFAAVLPHKVQVLEVIAPLLAQESMPQRDTIVRQVHGALQALSVCQQALQLDACRCASRLLRDPRTHPGICDALTEHVLLPLLQASAEAVRLRLFEEEVRNWVTEAGRAPALGCFYMQTAAFSCLALMHRLCPLTELRGSISTAFTGRNPNTTGVELTLEVLKACRAAWQSPNTGGDDNSAEEADGDVGDSACADAPRRYRQAAFRCLLATLSQTQQAEKVFCRCFFQERSVAGWNGLFLVKRPGVAVTDLLDAVGEVQLWRDMDRCQVPELFAHLLRHFPSSSVTPGEPPEWVRHVVAVLRQPQLRLPVRMVFYEMICRHERFFGTFARCIFDGVADAVAAMAPSERAGKVIWELLALLTRWHREGSSRALAVGSAASLKALARYAAVHLAWEHSFTACEGSRALDPTSHKRLAELLEQFRRAQGAALAIRSTSQPLTAAEMKMLLSHPAYERHAALEVIYLITNACGCLGCTGDSREVVEVYDLLGAFLGASASPQLYHITARLVGLEHRLLSEAATREPSSAVRKLLRDALRGTVCAILSVCKSDKKFLEVLEAMQEDRSGDLVYQLLSRTDLLRRYSIRKDSEKLLTLRVLARAGTYVADNYDSIHVCLSGLLRGGQGEPLLGICTVVKNALPHMSMESVRHVLRDLCCLDVLQAMESAEPARIAFYKMGLAALRRWTVVREDQEKQDGGGSVSADAEAFLVRRGLRDASPAVQGAVLEYLDVHAQHVPDTMWGRLTCLFTAEDGASGDGHSGSGGWVRHVALLLLSLSKRSRDFANPTYFCPEALHSEGASPTLATSADTAAESSVAQRQPRSAPLFSEAVQCGSPAEAATANAACPITAALAQIYVPPALVPQPPHQQQQPLSGARRPRATGAWRLGAAPCAAATAVTRSWLRLESGDSEQENAVISAGVMASRQISATMQRNAAHGAALQAGRSVMNAPSAAPSLESNTAGRLSEVRLTLQSLLVPLQVLCLHEDEVAARVLIDLISNAAVASPVTSESPHIVSLCSALTSLLPKFQSGATTRQCELAKNPFTLFVALELLLHAQAAGWSSLASLDCAALVRLTSDVQAYGGSVPTAFLPVVDGTAHVVEKLLSSLQPSAARGVPTRPSLEFPALGWHAYHVAQRLRRHDDAACQAALQLFRATRRHEAPVIQLQGALDAMEVGGAAYSMRVIAKLLEDEEKEAAAAVATVASPATHVSGGAFALFAAREEVLRHYRSRASRLLLDWCGAASALQSATPVGAGGSGEVSVEGVRLRLRAQLQLMCNGAASAVTAEASTASRHRTGFEWGACLMANGRWLDCQLHAETSVDHLLESTASHYDSGGSSLVCGYLAANSLSQLADAAQVLRFVSTSAASSAGVALQTYLDTMPALVPLSGAYGSLFIDDVLLIRRLIIDYHVQSTGDLLGSLQFTDNERHKLVAQIHELLGTWTVQQCSELLLLPEKTSAIETIASKADHATLSEPTRCALELLKKRSSLFSIAVTPREASGASREEALAAFQKATGKDVQQRAAAGLLSPAAARQWAADVAQCEVEIFASIGSILSIPAGSAASVQKREIWVSTLKENLRDTIPSHVALLNALEKLLPPVSRGDGTLADMGGDAKDAARASYITAATQSLWQLYANTFLWCAQAVGDRSMQVGSGGHLPVSARVPRLLSLFALPRVAEAAAQAQWRGTWEALVMLPTLVWLPWATLLVNALLQTEHAVLARILLRLCRERGQVLYYPINCAWRSLADLGKRRNAGRAVDDDLTRELAELHKWHRSHRMALVAEFAAALDELVEPQHRLEVRLSEVESLVKQHEQCTRGGGGAQAEYLMAALQLYERCKSDLMDPARWGRAQLYHRRAAQVLQELDRRNAFSAEVLKSGEQFRSAKREALRQVAQTLSTLSTSASNSATRSQELRLYSERLQHALGRSATAATTTTTQLGYTSDAAEPILQPVQPTHLLHTPPDAAQQCCTLVGVADRVLVLKSKRLPKKVDIYTSAGICTYMVKGGEDLRLDQRIQEVFTFANLCLLVSPRSRLSALTIRTYAVVPVSPLVGLICWVPRTTPLQELMKEATPPDAHDAVARFCRARGKPQEILPLYKTAHITGIPEQEYKDLVYCLRQSALVESLQSIATDHCSWLGARDAFLDTNAAASMASFVLGVGDRHAGNLLVDLLNSELVAIGFGLAFGDATRKLPVLELMPFRHTPQLQRVQGVLGDDVTRCRMRHVLHVLRAERQVVEGMVAALLMPDADAIGDEESRIAGHQLDVVRRKLNLEHPAGIILRDVARNAYVTQDKDVWIGVKACLCERKRDENGEDADLTETALSALHQEDVFVQRLLRIASDPRVLGRAYAGWQAYM
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060-......1070......1080......1090.......1100.......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560.-.....1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830.....-----.1840......1850......1860.-.....1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010----.......2020......2030........2040......---2050..----....2060......2070......2080......2090......2100......2110......2120......2130......2140....---..2150......-----2160......2170-.......2180......2190......2200......2210...------...2220......2230......2240.....------.2250......2260......2270......2280......2290......2300......2310......2320......2330.-.....2340......2350......2360......--2370......2380......2390......2400......2410......2420......2430......2440......2450...-----...2460.....--------.2470....-----..2480......2490......2500......2510.---.....2520......2530......2540......---2550......2560......2570......2580..--....2590......2600......2610-......-.2620......2630....--..2640......2650..-------....2660......2670......-2680......2690.....--.2700......2710......2720......2730......2740....----..2750......2760......2770--......2780......2790......2800.-----.....2810......2820-.........2830......2840......2850......2860......2870......2880......2890......2900......2910.......2920......2930....--..2940......2950......2960......2970......2980......2990......3000.-.....3010--...-.....3020--...---..--....3030......3040---.....----.3050......3060...--...3070......3080..----....3090......----3100......3110...--------...3120......3130.......3140-......3150......3160......3170......3180......3190......3200......3210.......3220......3230......3240......3250..-....3260----------....-..3270......3280......3290......3300.....------------.3310......3320.......3330-------......3340-----.........3350--......3360.......3370......3380-........3390..--....3400......3410---......3420....--..3430......------3440......3450-........3460......3470.-.....3480.....-.3490-..-....3500.....-.3510.....-.3520--......--..3530.....---.3540...------------...3550.----.....3560.--.....3570.-.....3580......3590......3600......3610......3620.....--.3630......3640..-....3650..-....-3660......3670......3680......3690-......3700......----3710......3720.....-.3730......3740......3750......3760......---3770......3780......3790......3800.......3810....-.------.-3820.-.......3830......3840......3850......3860......3870......3880......3890----.....--.--.3900......3910..----------------....3920----......3930......3940---......3950--....----..3960......3970......3980......3990......4000......4010......4020.....---.4030...---.--.-.4040---.........4050..-------.----...4060...---.-..4070---.....----..4080----.....-------------..4090-----------.......4100......4110......4120......4130......4140......4150......4160......4170.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
D
E
V
I
N
V
I
S
K
C
I
T
Q
L
N
L
F
VDGP
A
A
HLSGTAAP
T
T
I
E
T
I
R
K
C
I
ADH
A
Y
L
F
TDHRI
N
G
Q
R
M
W
E
L
V
C
S
A
T
F
TVGEPRTPT
T
A
A
T
A
T
A
T
L
L
S
L
F
R
R
L
T
D
S
V
AASARA
P
E
A
D
I
L
K
H
L
V
K
L
L
R
D
AVKPPLVRGASP
G
Q
L
R
C
L
F
Q
A
A
M
R
L
L
K
L
L
L
P
L
K
KRAD
V
Q
T
E
C
L
H
L
L
L
A
L
M
Q
L
S
D
L
Q
E
A
H
C
A
V
VAS
G
D
E
V
A
Q
V
A
K
L
C
A
D
I
CGAKH
D
V
A
LRPQNA
S
M
Q
L
L
G
C
L
CEQP
A
Y
V
H
A
L
S
G
Q
L
A
E
R
I
L
K
C
F
L
D
V
A
R
N
L
A
Q
R
A
E
V
N
Q
T
L
G
E
G
L
L
R
G
L
A
G
V
L
GSFPLRCEEDA
P
A
L
T
L
I
N
N
I
V
L
S
A
L
MLGETST
N
Y
T
F
C
L
S
A
L
F
L
L
R
R
RASDTLA
P
F
T
L
L
C
A
A
E
Y
S
V
A
L
R
S
L
W
M
HRNK
D
V
R
R
E
T
H
A
A
A
A
V
F
W
S
A
L
S
S
Q
L
Q
Q
R
C
S
S
EVADANTTRNT
A
A
S
H
K
L
H
S
I
V
E
F
L
L
R
SLDSSADP
E
A
S
Y
A
L
E
A
L
Y
H
L
L
P
A
V
A
ALS
G
P
Q
A
L
Q
T
M
S
T
R
L
E
E
RVG
G
L
L
I
TAS
A
Q
R
T
E
A
L
F
Q
Q
V
P
Y
L
L
A
T
L
G
Q
L
L
T
LLPSVS
P
R
Q
Q
A
V
V
R
E
L
L
D
W
V
L
L
LYPHPKFYNREKTV
P
G
I
V
L
V
I
R
A
L
THHPRAPH
N
T
L
P
R
L
L
S
E
R
T
L
E
L
VGEAP
G
A
A
M
M
R
LAGERI
S
T
E
E
R
L
D
R
M
A
T
L
W
T
R
L
L
T
TREESGAEA
E
A
E
S
K
Q
R
L
S
A
A
F
Y
R
A
C
T
G
F
C
E
R
A
R
L
E
V
I
V
KSN
S
E
A
T
L
E
R
I
L
V
DGVDGVQPSF
P
T
H
Y
S
A
F
L
S
F
V
D
F
F
V
R
L
S
EGLKGSGGVCRP
P
A
E
E
L
T
A
W
L
E
A
L
V
RGAS
A
A
L
H
V
S
G
F
Y
T
L
L
H
R
T
V
VGVEGVCPHSLTHQRPYTDASLASGNSDVTSDGHHENHL
C
V
S
P
L
L
R
H
F
L
S
T
E
C
L
R
R
V
HVY
S
D
E
L
L
Y
Q
C
A
M
C
V
V
V
G
A
A
LVGSE
D
R
G
E
LAGSRARAC
D
D
H
R
R
L
D
A
Y
V
R
A
F
K
V
V
M
TATPTSL
Q
A
E
SVAGST
N
E
V
V
CSFGSSP
A
I
L
ESN
R
Q
H
A
L
R
V
L
E
K
K
ACRSP
R
W
A
A
A
V
L
P
A
L
T
S
A
L
R
S
A
E
V
V
A
A
V
R
A
P
V
Q
M
L
A
A
RHG
V
A
I
A
A
E
L
Q
HHSNE
A
T
F
A
L
L
CRGEPASNGRRDS
M
P
R
W
L
A
TMQ
P
V
T
V
P
L
VPVDSA
L
H
I
G
Y
L
V
P
L
V
S
R
L
S
L
YGKH
P
A
V
R
T
A
A
A
E
V
L
Y
W
C
V
V
W
V
IGKKVNDWGS
A
V
F
P
P
L
L
S
L
A
S
L
A
RTSTGGSGGG
G
G
S
M
V
H
Q
E
L
H
G
L
L
M
Q
A
A
R
W
FGRSAG
T
P
E
E
A
E
L
F
V
S
V
L
L
R
GLGE-REG
T
Q
R
Q
V
A
T
E
A
L
F
A
YAIPPADEPQTV
T
P
-
H
F
R
A
V
I
G
R
L
V
-
R
M
EC
G
V
S
E
W
S
R
L
G
A
A
H
C
L
H
V
M
M
R
R
L
C
KVRVP
G
L
V
C
T
V
Q
A
V
A
Q
G
A
V
G
C
L
R
R
C
TEAPIWGAMETA
T
C
N
E
V
Q
E
S
L
R
W
L
G
A
Y
C
H
D
I
R
Q
LE
N
E
E
E
Q
R
E
A
D
R
F
A
A
D
L
V
H
A
A
R
A
V
L
P
A
L
A
RRH
T
V
C
A
I
T
L
L
Q
T
L
P
AVTHTNASA
R
Q
V
L
L
L
S
Q
E
L
I
C
E
Q
Q
QRL
G
P
A
A
V
R
S
L
D
S
TVG
G
C
A
T
L
V
A
L
L
QSGYGTE
T
N
K
R
A
I
A
E
AVT
P
V
I
CTRADDC
S
V
E
T
E
L
L
R
L
L
T
V
V
L
Q
A
I
V
E
E
A
R
V
ATHESRCI
S
P
H
I
V
R
W
L
L
E
L
V
D
VVPEQTHA
T
H
F
S
L
L
L
T
P
T
V
I
A
Q
A
A
R
V
MVAG
A
K
V
T
V
E
NCAGDVGEDATAGVPLRRCAPSSQLA
P
T
A
R
W
C
L
E
L
I
E
F
L
M
R
VAGQRRR
G
A
Q
V
I
E
D
V
L
C
A
I
RET
S
V
F
T
V
F
TAA
S
P
A
R
Q
L
I
D
A
LSVG
P
S
A
LVT
G
P
V
A
L
A
A
A
L
C
Q
MEAPCSSG
T
T
T
L
W
M
R
I
A
D
SMKI
S
P
K
T
V
V
A
M
L
L
G
L
LRNSAALNAT
G
G
E
E
V
C
E
G
L
L
V
L
M
LSEP
D
P
A
L
L
R
Q
H
L
R
D
L
L
A
-
S
D
A
V
Q
HNIFTSS
S
F
A
V
S
LEDGH
G
A
V
A
VSPSSR
S
T
S
V
L
L
S
R
A
F
D
S
V
M
N
R
C
W
Q
Q
A
SAAL
P
T
D
R
L
V
S
A
L
P
S
L
T
T
V
AM
S
E
D
A
LRSS
S
E
A
V
S
L
F
S
L
V
G
D
W
L
A
E
L
Q
R
R
SLT
S
E
H
D
K
V
L
C
R
V
C
A
N
L
V
A
A
E
R
E
M
R
QSTPTAAQDDGR
G
G
A
R
L
A
A
L
L
M
L
V
Q
LIGPAIRTD
T
T
L
S
S
A
L
C
D
L
V
L
F
VSK
P
A
N
M
C
S
L
L
A
SVDAT
E
H
V
V
W
G
F
H
V
L
A
ATMTPRPAR
R
S
L
A
V
FPV
D
L
R
A
V
E
M
A
F
D
F
L
N
E
V
L
NSALP
L
R
W
TELKTPREKTNG
A
D
V
V
RS
G
T
A
L
F
A
A
VLPH
K
V
-----
Q
V
L
E
V
I
A
P
L
L
A
QESMP
Q
R
D
T
I
V
R
Q
V
H
-
G
A
L
Q
A
L
S
V
C
Q
Q
A
L
Q
L
D
A
C
R
C
A
S
R
L
LRDPRTHP
G
I
C
D
A
L
T
E
H
V
L
L
P
L
L
Q
A
S
A
E
A
V
R
L
R
L
F
E
E
E
V
R
N
W
V
T
EAGRAPA
L
G
C
F
Y
M
Q
T
A
A
F
S
C
L
A
L
M
H
RLC
P
L
T
E
L
RGSIS
T
A
FTGRNPNTT
G
V
E
L
T
L
E
V
L
K
A
C
R
A
A
WQSPNTGGDDNSAEEA-----DGDVG
D
S
A
C
A
D
A
P
R
R
Y
R
Q
A
--
A
F
R
C
L
L
A
T
L
S
Q
T
Q
Q
A
E
K
V
---
F
C
R
C
F
F
----
Q
ERSVAGWN
G
L
F
L
V
KRPG
V
A
V
T
D
L
L
D
A
V
G
E
V
Q
L
W
R
D
M
D
RCQ
V
P
E
L
F
A
H
L
L
R
HFPSSSVTPGE
P
P
E
W
V
R
H
V
V
A
V
LRQPQLR
L
P
V
R
M
V
F
Y
E
M
I
C
---
R
H
E
R
F
F
G
T
F
A
R
C
-----
I
F
D
G
V
A
D
A
V
A
AMA--P
S
E
R
A
G
K
V
I
W
E
L
L
A
L
L
T
R
W
H
REGSS
R
A
L
AVG
S
A
A
S
L
K
A
L
A
R
Y
A
A
------
V
H
L
A
WEHSFTACEGSRALDP
T
S
H
K
R
L
A
E
L
L
E
Q
------
F
R
RAQG
A
A
L
A
I
RSTSQPL
T
A
A
E
M
K
M
L
L
SHP
A
Y
E
R
H
A
A
L
E
V
I
Y
L
ITNACGCLGCTGD
S
R
E
V
V
E
V
Y
D
L
L
G
A
F
LGASASP
Q
L
Y
H
I
T
A
R
L
-
V
G
L
E
H
R
L
L
S
E
A
ATRE
P
S
S
A
V
R
K
L
L
R
D
A
L
R
G
T
V
C
A
I
--
L
S
V
C
KS
D
K
K
F
L
E
V
L
E
A
M
Q
EDRS
G
D
L
V
Y
Q
L
L
S
R
T
D
L
L
R
R
Y
SIRKD
S
E
K
L
L
T
L
R
V
L
A
RAG
T
Y
VADNY
D
S
I
H
V
C
L
S
G
L
LRGGQGEP
L
L
G
I
-----
C
T
V
V
K
N
ALPHM
S
--------
M
E
S
V
R
H
V
L
R
-----
D
L
C
C
L
D
V
L
Q
A
M
ESAEP
A
R
I
A
F
Y
K
M
G
L
A
A
L
R
R
W
T
VVRE---DQEKQDGGGSVS
A
D
A
E
A
F
L
V
R
RGLRDA
S
P
A
V
Q
G
A
V
---
L
E
Y
L
D
V
H
A
Q
HV
P
D
TMWG
R
L
T
C
L
F
TAEDGASGDGHSG--S
G
G
W
V
R
H
V
A
L
L
L
L
S
L
S
K
RSRDFANP
T
Y
--F
C
P
E
A
L
-HSEGASPTLATSADTA
A
E
S
--
S
V
A
QRQPRSA
P
L
F
S
E
A
V
Q-------CGSPAEAATANAAC
P
I
T
A
A
L
A
Q
IY-VPPALVPQPPHQQQQPLSG--ARRPRATGAWRLGAA
P
C
A
A
A
T
A
V
T
R
S
W
LRLESGDSEQEN
A
V
I
S
A
G
V
M
A
S
----
R
Q
I
S
A
T
M
Q
RNAAH
G
A
A
L
Q
A
G
R
S
VMNA--PSAAPSLESNTAG
R
L
S
E
V
R
L
T
L
Q
S
L
L
V
P
L
Q
V
-----
L
CLH
E
D
E
V
A
A
R
V
L
I
D
L
----ISNAAVASPVTSES
P
H
I
V
S
L
C
S
A
L
T
S
L
L
P
K
F
QSGATT
R
Q
C
ELAKN
P
F
T
L
F
V
A
L
E
L
L
L
H
AQAAG
W
S
S
L
A
S
L
D
C
A
A
L
V
R
L
T
S
D
V
Q
A
YGGSVP-
T
A
F
L
PVVDG
T
A
H
V
V
E
K
L
L
S
SLQPSAAR--GVPTRPSLEFPA
L
G
W
H
A
Y
H
V
A
Q
R
L
R
RHD
D
A
A
C
Q
A
A
L
Q
L
F
R
A
T
R
RHEA
P
V
I
Q
L
QGAL
D
A
M
E
VGG
A
A
Y
S
-
M
R
V
I
A
K
L
----
L
E
D
-
E
E
K
E
A
A
-----
A
A
V
---
A
T--VASPATHVSGGA
F
A
L
F
A
A
---
R
E
E
V
L
----
R
H
Y
R
S
R
A
S
R
L
L
L
D
WCG
A
A
--
S
A
L
QSATPVGAGGSG
E
V
S
V
----
E
G
V
R
L
R
L
R
A
Q
L
Q
L
M
----CNGAA
S
A
V
T
AEASTASR--------HRTGFEW
G
A
C
L
MAN-
G
R
W
L
D
C
Q
L
HAE
T
S
-
V
D
H
L
L
E
S
T
A
S
HYDSGGS
S
L
V
C
G
Y
L
A
A
N
S
L
S
Q
L
A
D
A
A
Q
V
L
R
F
V
STSAASSA
G
V
A
L
Q
T
Y
L
D
TMPALVPL-SGAY
G
S
L
F
I
D
D
V
L
L
I
R
R
L
I
I
D
YHVQSTG
D
L
L
G
S
L
QFTD
N
E
R
H
K
L
V
-
A
Q
I
H
E
L
L
G
----------
T
W
T
V
-
Q
Q
C
S
E
L
LLLPE
K
T
S
A
I
E
T
I
A
SKADHATLS
E
P
T
R
C
A
L
E
L
L
K
K------------RSS
L
F
S
I
A
VTPRE-ASGA
S
R
E
E
A
L
A
A
-------
F
Q
K
AT
G
K
--------
D
V
Q
Q
R
A
AAGLL
S
P
--
A
A
A
R
Q
W
A
-
A
D
V
A
Q
C
E
V
E
I
F
A
SI
G
S
I
LSIP---AGSAAS
V
Q
K
R
E
I
W
V
--
S
T
L
K
E
N
L
R
D
T
I
P
S
H
V
A
L
L
---
N
A
L
E
K
LLPPVSRGD--G
T
L
ADMGGD
A
K
D
------
A
A
R
A
S
Y
I
T
A
A
T
Q
---
S
L
W
Q
L
Y
A
N
T
F
L
W
C
A
Q
A
VGDRSMQ-VGSGGHLPV
S
A
R
V
P
-
R
L
L
S
L
-
F
A-L
P
R
V
A
E
A
A
A
Q
A
QW-R
G
T
W
E
A
L
V
M
L
-
P
T
L
----
V
W
L
P
W
A
--
T
L
L
V
N
A
L
L
Q
T
E
---
H
A
V
L
A
R
I
L
------------
L
R
L
C
R
ERG----
Q
V
L
Y
Y
PI
N
C
A
--
W
R
S
L
A
D
L
G
KR-RNAGRAV
D
D
D
L
T
R
E
L
A
E
L
H
K
W
H
R
S
H
R
M
A
L
V
A
E
F
A
A
A
L
D
E
L
VE
P
Q
H
R
L
E
V
R
L
S
E
V
--
E
S
L
V
K
Q
H
E
Q
C
TRGGGG
A
-
Q
A
E
Y
L
M
A
A
L
Q
-
L
Y
E
R
-
C
K
S
DLM
D
P
A
R
W
G
R
A
Q
L
Y
H
R
R
A
A
Q
V
L
Q
E
L
D
RRNA
F
-
S
A
E
V
L
KS
G
E
Q
F
R
S
A
K
R
----
E
A
L
R
Q
V
A
Q
T
L
S
T
L
STSASN-SA
T
R
S
Q
E
L
R
L
Y
S
E
R
L
Q
H
A
LGRSATA
A
T
T
T
T
T
QLGYTSDA
A
E
---
P
I
LQPVQPT
H
L
LHTP
P
D
A
A
Q
Q
C
C
T
L
V
GV
A
D
R
-
V
L
V
L
KSKRLP
K
K
V
D
I
Y
T-S------A-
G
-
I
-
C
-
T
Y
M
VKGGEDL
R
L
D
Q
R
I
Q
E
V
F
T
F
A
N
L
C
L
L
VSPRSR
L
S
A
L
T
I
R
T
Y
A
V
V
P
V
S
P
L
V
G
L
I
CWVPRT
T
P
L
Q
E
L
M
K
E-----ATPP
D
--
A
--
H
D
A
V
A
R
F
C
R
ARG
K
P
Q
E
I
----------------
L
P
L
Y
KTAH----ITGI
P
E
Q
E
Y
K
D
L
V
Y
C
L
R
Q
S
A
---
L
V
E
S
L
Q
S
I
A
T
--
D
H
C
S
----WLGA
R
D
A
FLDT
N
A
A
A
S
M
A
S
F
V
L
GVGDRH
A
G
N
L
L
V
D
L
LNSE
L
V
A
I
G
FGLAFGDATRKL
P
V
L
ELMPFRHT
P
Q
L
---
Q
R
V
Q
G
V
LG---
D
--
D
-
V
T
------
R
C
R
M
R
H
V
L
H
V
L
R
A
E
R
-------
Q
----
V
V
E
G
M
V
A
A
L
L---M-PDADA----IGD
E
E
----
S
RIAG-----
H
Q
L
D
V
-------------
V
R
R
-
K
L-----------NLEHP
A
G
I
I
L
R
D
V
ARNAYVTQDK
D
V
W
I
G
V
K
A
C
L
C
E
RKRDENGEDA
D
L
T
E
T
A
L
S
A
L
H
QE
D
V
F
V
Q
R
L
L
R
IASD
P
R
V
L
G
R
AYAGWQAYM
59
Fugue
58.41
15%
-11
- C1 -
-
5FVM
-
?
A:
[85-2469]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
K
A
F
D
L
I
F
T
K
L
N
-----
Q
L
E
R
V
A
A
S
Y
E
L
K
S
C
L
I
S
L
V
S
T
E
Y
F
Q
R
F
S
N
D
I
N
N
K
V
F
E
L
I
H
D
S
N
E
K
L
G
G
V
L
A
V
D
T
L
I
D
E
L
P
N
Q
T
S
R
L
A
N
Y
L
R
V
L
IDI
E
V
M
R
A
A
A
T
T
L
G
K
L
A
VL
T
S
E
F
V
E
F
E
V
K
T
C
I
E
W
L
T
Q
E
Y
R
K
H
A
S
L
L
I
I
S
S
Y
P
F
V
N
S
I
L
D
N
I
W
R
A
LRK
L
V
I
R
T
D
A
A
V
T
L
G
K
C
L
T
S
S
L
T
K
K
W
V
Q
R
L
F
N
G
C
I
H
G
------
T
L
L
V
Y
R
Q
L
V
S
L
E
L
K
D
K
Y
E
E
I
Y
E
T
T
M
K
H
R
D
N
I
I
I
R
K
E
I
Y
A
I
I
P
V
L
A
A
D
P
K
L
F
T
Q
K
Y
L
D
A
T
M
I
H
Y
L
T
L
L
L
S
----
D
K
G
P
I
L
V
S
I
G
D
I
A
-
Y
H
I
G
P
Y
L
D
A
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V
E
N
L
R
D
G
L
E
T
K
F
K
T
R
K
E
K
D
I
F
Y
C
V
S
--
K
L
A
C
A
V
R
P
L
L
A
K
Y
L
N
R
G
L
L
D
A
S
D
H
M
Q
E
T
L
L
V
I
C
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I
S
M
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V
T
V
N
E
K
L
L
N
I
I
C
L
V
L
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G
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F
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P
P
G
S
P
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P
M
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S
L
S
S
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T
A
R
A
Y
R
D
Q
S
L
L
R
K
T
GT
L
D
A
M
I
L
R
K
A
L
R
M
L
S
DIKPKY
S
L
T
E
F
I
R
R
V
I
I
-----
S
Y
M
E
H
D
N
M
Q
V
R
K
L
A
A
L
T
S
C
D
L
F
V
K
S
L
Y
A
L
N
V
V
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V
L
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LL
T
V
A
I
T
D
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V
A
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R
L
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L
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H
L
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L
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N
T
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L
L
F
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A
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NDE
V
F
A
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A
M
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L
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V
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L
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Q
L
L
T
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L
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H
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--
M
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K
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L
L
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L
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L
-
P
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A
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A
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V
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D
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K
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A
A
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A
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P
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L
L
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L
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L
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LEGE
F
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--
56
Fugue
57.22
15%
-9
* C1 *
-
5H64
-
MTOR_HUMAN
A:
[210-2549]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
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R
Q
I
W
W
E
R
L
Q
G
C
-
Q
R
I
V
E
D
W
Q
K
I
L
M
V
------------
R
S
L
V
V
S
-----
P
H
-
E
D
M
R
T
W
L
K
Y
A
S
L
-------
C
G
K
S
G
R
L
--------
A
L
A
H
K
T
L
V
L
L
L
G
V
--
D
P
S
R
Q
L
D
-
H
P
L
P
T
V
H
P
Q
V
T
Y
A
Y
M
K
N
M
W
K
S
---
A
R
K
I
D
A
F
Q
H
M
Q
H
F
V
--
Q
T
M
Q
Q
Q
A
Q
H
A
I
A
T
E
D
Q
-----
Q
H
K
Q
E
L
H
K
L
M
A
R
C
F
--
L
K
L
G
E
W
Q
L
N
L
Q
G
IN
E
S
T
I
P
K
V
L
Q
Y
Y
S
A
A
T
E
H
D
R
S
W
Y
K
A
W
H
A
W
A
V
M
N
F
E
A
V
L
H
Y
K
H
Q
N
Q
A
R
D
E
K
K
K
V
T
E
D
L
S
-
K
T
L
L
M
-
Y
T
-
V
P
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
N
L
Q
D
T
L
R
-
V
L
T
----
L
W
F
D
Y
G
HW
P
D
V
N
E
A
L
V
E
G
V
---
K
A
I
Q
I
D
T
W
------------
L
Q
V
I
P
Q
L
I
----
A
R
I
D
T
P
--------------------
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
---
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
R
H
N
A
A
N
K
I
--
L
--
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
-
S
E
E
L
I
R
V
A
I
L
-
W
H
E
M
-
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
-
G
P
Q
T
L
K
E
-
T
S
F
N
Q
A
Y
G
----
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
-
G
N
-
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
---
L
P
Q
L
T
S
L
E
L
Q
Y
V
S
P
K
L
L
MCR
D
L
E
L
A
V
P
G
T
Y
D
P
N
Q
P
I
I
R
I
Q
S
------
I
A
P
S
-
L
Q
V
I
T
S
K
Q
R
P
R
K
L
T
L
M
G
-
S
------
N
-
G
H
E
-
F
-
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
-----
Y
R
E
K
K
--
K
IL
L
N
I
E
H
R
I
M
L
R
M
A
P
D
Y
D
H
----------------
L
T
L
M
Q
K
V
E
----
V
-------
F
E
H
A
V
N
N
T
A
G
D
D
---
L
A
K
L
L
W
L
K
S
P
--
S
S
E
V
----
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
---
T
N
A
M
E
V
T
G
---
L
--
D
G
N
Y
------
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
-------
D
----
S
V
M
A
V
L
E
A
F
V
---
Y
D
P
L
L
N
W
----
R
L
M
D
T
N
TA
L
N
K
K
A
I
-----
Q
I
I
N
R
-------------
V
R
D
-
K
L
T
GRDFSHDDTL
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
--------------------------------------------------------
57
Fugue
51.47
18%
3
- C1 -
-
4JSP
1
MTOR_HUMAN
A:
[10-1174]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
A
K
C
R
A
Y
A
K
A
L
H
Y
K
E
L
E
F
Q
K
G
P
T
P
A
I
-
L
E
S
L
I
S
I
----
N
N
K
L
Q
Q
P
E
A
A
-----
A
G
V
---
L
E
--
Y
A
M
K
H
F
G
E
L
E
I
Q
A
T
W
Y
E
K
L
HE
W
E
D
A
L
----
V
A
Y
D
K
K
M
D
T
N
K
D
D
P
E
L
M
L
--
G
R
M
R
C
L
E
A
L
G
E
W
G
Q
L
H
Q
Q
C
C
E
K
W
T
L
V
N
D
E
T
Q
A
K
M
A
R
M
----
A
A
A
A
A
W
G
L
G
Q
W
D
S
M
E
E
Y
T
C
M
IPRDT
H
D
G
A
F
Y
R
A
V
L
A
L
H
Q
-
D
L
F
S
L
A
Q
Q
C
I
D
K
A
-
R
D
L
L
D
A
E
L
T
A
M
A
G
E
S
Y
S
R
A
Y
G
A
M
V
S
C
H
M
L
S
E
L
E
E
V
I
Q
-----
Y
K
L
V
P
E
R
R
E
I
I
R
Q
I
W
W
E
R
L
Q
G
C
Q
R
I
------
V
E
D
W
Q
K
I
L
M
V
R
S
L
V
V
S
P
H
E
D
M
R
T
W
L
K
Y
A
S
L
C
G
K
S
G
R
L
A
L
A
H
K
T
L
V
L
L
L
G
----------
V
---------------------------------
D
P
S
R
Q
L
D
H
P
L
P
T
------------
V
H
P
Q
V
T
Y
A
Y
M
K
N
M
-
W
K
S
A
R
K
I
D
A
F
Q
H
-------
M
Q
H
F
V
-
Q
--------
T
M
Q
Q
Q
A
Q
H
A
I
A
T
E
D
Q
Q
H
K
Q
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L
H
-
K
L
M
A
R
C
F
L
K
L
G
E
W
Q
L
N
L
Q
G
I
N
---
E
S
T
I
P
K
V
L
Q
Y
Y
S
A
A
--
T
E
H
D
R
S
W
Y
K
A
W
H
A
W
A
V
M
N
---
F
E
A
V
L
H
Y
K
H
Q
N
Q
A
R
--
D
E
-
K
K
K
V
T
E
D
L
S
------
K
T
L
L
M
Y
T
V
P
A
V
Q
---
G
F
F
R
S
I
S
L
S
-----------------
R
G
N
N
L
Q
D
T
L
R
V
L
-
T
L
W
F
D
-
Y
G
H
W
P
D
V
N
E
A
L
V
E
G
V
K
-
A
--------
I
-
Q
I
D
----
T
W
L
Q
V
I
--
P
Q
L
I
-
A
R
I
D
T
P
---
R
P
L
V
G
R
L
I
------------
H
Q
L
L
T
D
I
G
----
R
--
Y
H
P
Q
A
L
I
--
Y
P
L
T
V
A
S
K
S
T
-
T
T
A
R
H
N
A
A
N
K
I
L
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
--
Y
F
------------
G
E
R
-
N
V
K
G
M
F
E
V
L
E
-
P
L
H
A
-
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
-
S
G
N
V
-
K
D
L
T
Q
A
W
D
L
Y
Y
----
H
V
F
R
R
I
S
K
Q
L
P
Q
L
T
----------
S
L
E
L
Q
Y
V
S
P
K
L
L
M
C
R
D
L
E
L
A
V
P
G
T
------
Y
D
P
N
Q
P
I
---
I
R
I
Q
S
I
A
P
----------------------
S
-
L
Q
V
I
T
S
K
Q
R
P
R
K
L
T
L
M
G
-
S
------
N
-
G
H
E
-
F
-
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
-----
Y
R
E
K
K
KI
L
--
L
N
I
E
H
R
I
M
L
R
M
A
P
D
Y
D
H
----------------
L
T
L
M
Q
K
V
E
----
V
-------
F
E
H
A
V
N
N
T
A
G
D
D
---
L
A
K
L
L
W
L
K
S
P
--
S
S
E
V
----
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
---
T
N
A
M
E
V
T
G
---
L
--
D
G
N
Y
------
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
-------
D
----
S
V
M
A
V
L
E
A
F
V
---
Y
D
P
L
L
N
W
RLMD
T
N
T
A
L
----
N
K
K
A
I
-----
Q
I
I
N
R
-------------
V
R
D
-
K
L
T
GRDFSHDDTL
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
--------------------------------------------------------
54
HHSearch
45.54
13%
-139
- C3 -
-
2QK2
-
MSPS_DROME
A:
[316-474]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
G
A
L
V
S
A
L
K
K
V
I
T
K
D
S
N
V
V
L
V
A
M
A
G
K
C
L
A
L
L
A
K
G
L
-
A
K
R
F
S
N
Y
A
S
A
C
V
P
S
L
L
E
K
F
K
E
-----------
K
K
P
N
V
V
T
A
L
R
E
A
I
D
A
I
Y
A
S
T
----
S
----
L
E
A
Q
Q
E
S
I
V
E
S
L
S
N
-
K
N
P
S
V
K
S
E
T
A
L
F
I
A
R
A
L
T
R
T
Q
P
T
--
A
L
N
K
K
L
L
K
L
L
T
T
S
L
V
-
K
T
L
N
E
P
D
P
T
V
R
D
S
S
A
E
A
L
G
T
L
I
K
L
M
G
D
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Fugue
42.83
13%
-22
- C1 -
-
5IFE
-
SF3B1_HUMAN
C:
[463-1304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
P
F
L
K
P
D
D
I
Q
Y
F
D
K
L
L
V
D
V
D
E
S
E
E
Q
K
E
R
K
I
M
K
L
L
L
K
I
K
N
G
T
P
P
M
R
K
A
A
L
R
Q
I
T
D
-
K
A
R
E
F
G
A
G
P
L
F
-
N
Q
I
L
P
L
L
M
SPT
L
E
D
-
Q
E
R
H
L
L
-----
V
K
V
---
I
D
R
I
L
Y
K
L
D
D
L
V
R
P
Y
V
H
K
I
L
V
V
---
I
E
P
L
L
IDED
Y
Y
A
R
V
E
G
R
E
I
I
S
N
L
A
K
A
A
G
L
A
T
M
I
S
T
M
R
P
D
I
D
N
M
D
E
Y
V
R
----
N
T
T
A
R
A
F
A
V
V
A
S
A
L
GIPS
L
L
P
F
L
K
A
V
C
K
S
K
K
S
W
Q
A
--------
R
H
T
G
I
K
I
V
Q
Q
I
A
I
L
M
G
C
A
I
L
P
H
L
R
S
L
V
E
I
I
E
H
G
L
V
D
E
Q
Q
K
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A
L
A
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A
A
L
A
E
A
A
T
P
Y
G
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F
D
S
V
L
K
P
L
W
K
G
I
R
Q
H
R
G
K
G
L
A
A
F
L
K
A
I
G
Y
L
I
P
L
M
D
A
E
Y
A
N
Y
Y
T
R
E
V
M
L
I
L
I
R
E
F
Q
-------------
S
P
D
E
E
M
K
K
I
V
L
-
K
V
V
K
Q
C
C
G
----------
T
D
G
V
E
A
N
Y
I
K
T
E
I
L
P
P
F
F
K
H
F
W
Q
H
R
M
A
L
D
R
R
N
Y
R
Q
L
V
D
T
T
V
E
L
A
N
K
VG----------
A
A
E
I
I
S
R
I
V
D
D
L
K
D
E
A
E
Q
Y
R
K
M
V
M
E
T
-------
I
E
K
I
M
G
N
LGAADID
H
K
L
E
E
Q
L
I
D
G
I
L
Y
A
--
F
Q
E
Q
T
T
E
D
S
V
M
L
N
G
F
G
T
V
V
N
A
L
G
K
R
V
K
P
Y
---
L
P
Q
I
C
G
T
V
L
W
R
L
N
N
KS
A
K
V
R
Q
Q
A
A
D
L
I
S
R
T
A
V
V
M
---
K
T
C
Q
E
-
E
K
L
M
G
H
L
G
--
V
V
L
Y
E
Y
L
G
E
E
Y
P
------
E
V
L
G
S
I
L
G
A
L
K
A
---
I
V
N
V
I
G
M
H
K
M
T
P
P
I
K
D
L
L
P
R
L
T
P
-
I
L
K
N
R
H
E
K
V
Q
E
N
C
I
-
D
L
V
G
R
-
I
A
-
D
R
G
A
E
Y
V
S
A
R
E
W
M
-
R
I
C
F
E
L
L
E
L
L
K
A
H
K
----
K
A
I
R
R
A
--
T
V
N
T
F
G
Y
I
A
K
A
I
GP
H
D
V
L
A
T
L
Q
------------
N
R
V
C
T
T
V
A
----
I
A
I
V
A
E
T
C
S
P
--
F
T
V
L
P
A
L
M
N
E
Y
R
V
P
E
L
N
V
Q
N
G
V
L
K
S
L
S
F
L
F
E
Y
I
G
E
M
G
K
D
Y
I
Y
A
V
T
P
L
L
E
D
A
L
--
M
D
R
D
L
V
H
R
Q
T
A
--
S
A
V
V
Q
H
M
S
L
G
V
Y
G
F
G
C
------
E
D
S
L
N
H
-
L
L
N
Y
-
V
W
P
N
V
F
E
T
S
--
P
H
V
I
Q
A
V
M
G
A
L
E
G
L
R
V
A
I
G
P
C
R
M
-
L
Q
Y
C
L
Q
G
L
F
H
P
A
R
K
V
R
----
D
V
Y
W
K
I
Y
N
S
I
Y
I
G
S
Q
D
A
L
I
-
A
H
Y
P
R
I
Y
N
D
D
K
N
T
Y
I
R
Y
E
L
D
Y
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
42.32
17%
7
- C1 -
-
5DFZ
-
VPS34_YEAST
C:
[4-875]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
I
T
F
C
------------
V
S
Q
D
L
D
V
P
L
K
V
K
I
-
K
S
L
E
G
H
K
P
L
L
K
P
-------
S
Q
K
I
L
N
P
--------
E
L
M
L
I
G
S
N
V
F
P
S
S
--
D
L
I
V
S
L
Q
-
V
F
D
K
E
R
N
R
N
L
T
L
P
I
Y
T
----
P
---
Y
I
P
F
R
N
S
R
T
W
D
Y
W
L
--
T
L
P
I
R
I
K
Q
L
T
F
S
S
H
L
R
I
I
LWE
Y
N
G
S
K
Q
I
P
F
F
N
L
E
T
--
S
I
F
N
L
K
D
C
T
L
K
R
------
G
F
E
S
L
K
F
R
Y
D
V
I
---
D
----------
H
C
E
V
V
T
D
N
K
D
Q
E
-
N
L
N
K
Y
F
Q
G
E
F
T
R
L
P
-
W
L
D
E
I
-
T
I
-
S
K
L
R
K
Q
R
E
N
R
T
W
P
-
Q
G
T
F
V
L
N
L
E
F
-
P
M
L
ELPV
V
F
I
E
R
E
--
I
M
N
T
N
D
P
I
E
E
K
---
Y
R
R
L
E
R
A
S
KNANLDKQVKPD
I
K
K
R
D
Y
L
N
----
K
I
I
N
Y
P
P
G
T
K
LT
A
H
E
K
G
S
I
W
K
Y
-
R
Y
Y
L
M
N
N
K
K
A
L
T
K
L
L
Q
S
T
N
L
R
E
E
S
E
R
V
E
V
L
E
L
M
D
S
W
A
E
--
I
D
I
D
D
A
L
E
L
L
G
S
T
F
--
K
N
L
S
V
R
S
Y
A
V
N
R
L
K
K
A
S
-
D
K
E
L
E
L
Y
L
L
Q
-
L
V
E
A
V
C
F
E
N
L
S
T
F
S
D
K
S
N
S
E
F
T
I
V
D
A
V
S
P
L
A
E
F
L
I
R
R
A
L
V
N
P
R
L
G
S
F
F
Y
W
Y
L
K
S
E
S
----
E
D
K
P
Y
L
D
Q
I
L
S
S
F
W
S
R
L
D
K
K
S
R
N
I
L
N
D
Q
V
R
L
I
N
V
L
R
E
C
C
E
T
I
K
R
L
K
D
T
T
A
K
K
M
E
L
L
V
H
L
L
E
---
T
K
V
R
P
L
V
K
V
R
P
I
A
L
P
L
D
P
D
V
L
I
C
D
V
C
P
E
T
S
K
-
V
F
--
K
S
S
L
S
P
L
K
I
T
F
K
T
-
T
------
L
-
N
Q
P
-
Y
-
H
L
M
F
K
V
G
D
D
L
R
Q
D
Q
L
V
V
Q
I
I
S
L
M
N
E
L
L
K
N
E
N
V
D
----
L
K
L
T
P
Y
K
I
L
A
T
G
P
Q
E
G
A
I
E
F
I
P
N
D
T
------------------------------------
L
A
S
I
----------------
L
S
K
Y
H
--
G
----
I
L
G
Y
L
K
L
H
Y
P
D
E
N
A
T
L
G
V
Q
G
-------------------------
W
V
L
D
N
F
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
V
T
P
-
D
G
H
F
F
H
A
D
F
G
Y
I
L
G
Q
D
P
K
P
F
P
P
L
M
K
L
P
----
P
Q
I
---
I
E
A
F
G
G
A
E
---
S
--
S
-
N
Y
------
D
K
F
R
S
Y
C
F
V
A
Y
S
I
L
R
-------
R
----
N
A
G
L
I
L
N
L
F
E
---
L
-
M
K
T
S
N
----
I
P
D
I
R
----
I
D
P
N
G
-----
A
I
L
R
V
-------------
R
E
R
F
N
L
-----------
N
M
S
E
E
D
A
T
V
H
F
Q
N
L
I
N
D
S
V
N
A
L
L
P
I
V
I
D
H
L
H
N
L
A
Q
Y
W
R
T
-----------------------------------------------
46
HHSearch
42.09
11%
-129
- C3 -
-
4G3A
2
CLASP_DROME
B:
[4-162]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
P
S
D
L
D
G
F
I
Q
Q
M
-
P
K
A
D
M
R
V
K
V
Q
L
A
E
D
L
V
T
F
L
S
D
D
T
N
S
I
V
C
T
D
M
G
F
L
I
D
G
L
M
P
W
L
T
G
-----------
S
H
F
K
I
A
Q
K
S
L
E
A
F
S
E
L
I
K
R
L
G
S
D
F
--
N
A
Y
T
A
T
V
L
P
H
V
I
D
R
L
G
D
-
S
R
D
T
V
R
E
K
A
Q
L
L
L
R
D
L
M
E
H
R
-
V
L
-------
P
P
Q
A
L
I
D
K
L
A
T
S
C
F
K
H
K
N
A
K
V
R
E
E
F
L
Q
T
I
V
N
A
L
H
E
Y
G
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
41.79
25%
14
- C2 -
-
5FVM
-
?
A:
[1843-2359]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
L
T
L
W
F
K
-
F
G
G
I
P
E
A
A
------
Q
A
M
H
E
G
F
G
L
I
-
K
I
D
----
N
W
L
E
V
I
--
P
Q
L
I
S
R
I
H
Q
P
N
---
Q
T
V
-
S
R
S
L
------------
L
S
L
L
A
D
L
G
K
AHP
Q
A
L
V
Y
P
L
T
V
A
--
I
K
S
--
D
S
V
S
R
-
Q
R
A
A
L
S
I
I
D
K
M
-----------
R
M
H
S
P
K
L
V
N
Q
A
E
L
V
S
D
E
L
I
----
R
V
A
V
L
W
H
E
L
W
Y
E
G
L
----
E
D
A
S
R
Q
F
F
G
E
H
N
T
E
K
M
F
A
T
L
E
P
L
H
E
M
-
L
K
-----------------
R
G
P
E
T
L
R
E
I
S
F
Q
N
S
F
-
G
R
D
L
N
D
A
Y
E
W
V
L
N
Y
K
R
TKDI
N
N
L
N
Q
A
W
D
I
Y
Y
N
V
F
R
R
I
S
R
-
K
L
P
Q
L
Q
T
L
D
L
-----
Q
H
-
V
S
P
K
L
S
A
A
K
D
L
E
L
A
V
P
G
T
Y
H
A
G
K
---
P
I
V
R
------
I
T
H
F
E
P
--------------
V
-
F
T
V
I
S
S
K
Q
R
P
R
R
V
I
I
K
G
-
S
------
D
-
G
-
K
D
Y
-
Q
Y
L
L
K
S
H
E
D
I
R
Q
D
N
L
V
M
Q
L
F
G
L
V
N
T
L
L
Q
N
D
P
E
S
F
Q
R
H
L
N
I
Q
Q
Y
P
A
I
P
L
S
P
K
T
G
L
L
G
W
V
P
N
S
D
T
F
H
V
L
I
R
E
H
R
E
A
S
K
I
P
L
N
--
I
--
E
H
R
I
M
L
---------
Q
M
----------------
A
P
D
Y
D
N
L
T
----
L
L
----
Q
K
V
E
V
F
T
Y
A
L
D
N
T
K
GQ
D
L
Y
K
V
L
W
L
K
S
R
--
S
S
E
S
----
W
L
D
R
R
T
T
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
I
T
G
K
V
V
H
I
D
F
G
D
C
F
E
A
A
I
L
R
E
K
Y
P
E
K
V
P
F
R
L
T
R
M
L
T
Y
A
M
E
V
S
G
I
E
G
---
S
--
F
-
R
I
------
T
C
--
E
N
V
M
M
V
L
R
D
N
K
-------
E
----
S
L
M
A
I
L
E
A
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
40.94
10%
-130
- C3 -
-
3WOZ
-
CLAP2_MOUSE
B:
[645-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
D
V
A
E
V
L
N
R
C
-
A
S
S
N
W
S
E
R
K
E
G
L
L
G
L
Q
N
L
L
K
N
Q
-
R
T
L
S
R
I
E
L
K
R
L
C
E
I
F
T
R
M
F
A
D
-----------
P
H
G
K
V
F
S
M
F
L
E
T
L
V
D
F
I
Q
V
H
K
D
D
L
--
Q
D
W
L
F
V
L
L
T
Q
L
L
K
K
M
G
A
D
L
L
G
S
V
Q
A
K
V
Q
K
A
L
D
I
T
-
R
E
S
F
P
N
D
----
L
-
Q
F
N
I
L
M
R
F
T
V
-
D
Q
T
Q
T
P
S
L
K
V
K
V
A
I
L
K
Y
I
E
T
L
A
K
Q
M
D
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
40.85
22%
-64
* C2 *
-
5C46
-
PI4KB_HUMAN
E:
[285-488]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
W
-
R
-
L
L
S
V
I
V
K
C
G
D
D
L
R
Q
E
L
L
A
F
Q
V
L
K
Q
L
Q
S
I
W
E
Q
E
----
R
V
P
L
W
I
K
P
Y
K
I
L
V
I
S
A
D
S
G
M
I
E
P
V
V
N
A
V
S
I
H
Q
V
K
K
Q
-----
S
Q
-----------------------------------------------------------------------
L
S
---
L
L
D
Y
F
L
Q
E
H
G
SY
T
T
E
A
----
F
L
S
A
Q
R
N
F
V
Q
S
C
A
G
Y
C
L
V
C
Y
L
L
Q
V
K
D
R
H
N
G
N
I
L
L
D
A
-
E
G
H
I
I
H
I
D
F
G
F
I
L
S
S
S
P
--------
S
A
F
K
L
T
T
E
F
---
V
D
V
M
G
G
L
D
GDM
F
--
N
-
Y
Y
------
K
M
L
M
L
Q
G
L
I
A
A
R
K
H
M
-------
D
----
K
V
V
Q
I
V
E
I
M
Q
Q--
G
-
S
----------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
40.09
13%
-3
- C1 -
-
1E8X
1
PK3CG_PIG
A:
[1-951]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
S
E
E
T
L
A
F
Q
-
R
Q
L
N
A
L
I
G
YDVTDVSNVH
D
D
E
L
-
E
F
T
R
R
R
L
V
T
P
R
M
A
E
V
A
G
R
D
P
K
L
Y
A
M
H
P
W
V
T
S
K
P
L
P
E
Y
L
L
K
K
I
TNN
C
V
F
I
V
I
H
R
S
T
T
S
Q
T
I
K
V
S
A
D
D
-
T
P
G
T
I
L
Q
S
F
F
T
K
M
ANERD
F
V
L
R
V
C
G
R
--------
D
E
Y
L
V
G
E
T
P
I
K
N
F
--
Q
W
V
R
Q
C
L
-
K
N
G
E
E
I
H
L
V
L
D
T
P
P
D
P
A
L
D
E
V
RKE
C
D
R
K
F
R
V
K
I
R
G
I
D
I
--
P
V
L
P
R
T
A
D
L
T
V
F
V
E
A
N
I
Q
---
Y
G
Q
Q
V
L
C
Q
R
R
T
S
P
K
PF
T
E
E
V
L
W
N
V
W
L
E
F
------
S
I
K
I
K
D
L
P
K
G
A
L
---
L
N
L
Q
I
Y
C
Q
L
L
Y
Y
V
N
L
L
L
I
D
H
R
F
L
-
L
R
H
G
E
Y
V
L
H
M
W
Q
L
S
-
G
F
N
A
D
-
K
L
-
T
S
A
T
N
P
D
K
E
N
S
M
S
-
I
S
I
L
L
D
N
H
P
I
-
A
L
E
----
M
P
N
Q
L
R
--
K
Q
L
E
A
I
I
A
T
D
P
---
L
N
P
L
T
A
E
D
------------
K
E
L
L
W
H
F
R
----
Y
E
S
L
K
D
P
K
A
Y
--
P
K
L
F
S
S
V
K
W
G
-
Q
Q
E
I
V
A
K
T
Y
Q
L
L
A
K
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
--
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
-
P
Y
H
D
S
A
L
A
R
F
-
L
L
K
R
-
G
L
R
N
-----
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
S
R
H
Y
Q
Q
R
F
-
A
V
I
L
E
A
Y
L
R
G
C
G
T
A
M
L
----
H
D
F
T
Q
Q
V
Q
V
I
D
M
L
Q
K
V
T
I
D
-
I
K
S
L
S
A
E
K
Y
D
V
S
S
Q
V
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
L
--------
N
L
P
Q
---
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
V
------------
I
E
K
-
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
-
A
DPTALS
N
-
E
-
T
-
I
-
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
----
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
-----
T
V
G
N
T
--
G
--
A
-----------------------------------------------------------
F
K
D
E
V
---
L
S
H
W
L
K
E
K
C
P
--
I
E
E
K
----
F
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
S
E
-
T
G
N
L
F
H
I
D
F
G
H
--------------
V
P
F
V
L
T
P
D
F
---
L
F
V
M
G
T
S
G
---
K
--
K
-
T
S
L
H
F
Q
K
F
Q
D
V
C
V
K
A
Y
L
A
L
R
H
H
T
-------
N
----
L
L
I
I
L
F
S
M
M
L
---
M
-
T
G
M
P
Q
----
L
T
S
K
E
----
D
-----------
I
E
Y
-------------
I
R
D
-
A
L
-----------
T
V
G
K
S
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
L
V
L
-------------------------------------------------
14
PsiBlast_PDB
39.87
28%
-149
- C2 -
-
5C46
-
PI4KB_HUMAN
E:
[375-491]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----
F
L
S
A
Q
R
N
F
V
Q
S
C
A
G
Y
C
L
V
C
Y
L
L
Q
V
K
D
R
H
N
G
N
I
L
L
D
-
A
E
G
H
I
I
H
I
D
F
G
F
I
L
S
S
S
P
--------
S
A
F
K
L
T
T
E
F
---
V
D
V
M
G
G
L
D
---
G
--
D
-
M
F
------
N
Y
Y
K
M
L
M
L
Q
G
L
I
A
A
R
KHMDKVV
Q
----
I
V
E
I
M
Q
Q
G
S
Q
---
L
-
P
----------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
39.14
28%
-145
- C2 -
-
5C4G
1
PI4KB_HUMAN
E:
[375-491]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----
F
L
S
A
Q
R
N
F
V
Q
S
C
A
G
Y
C
L
V
C
Y
L
L
Q
V
K
D
R
H
N
G
N
I
L
L
D
-
A
E
G
H
I
I
H
I
D
F
G
F
I
L
S
S
S
P
-----------
K
L
T
T
E
F
---
V
D
V
M
G
G
L
D
---
G
--
D
-
M
F
------
N
Y
Y
K
M
L
M
L
Q
G
L
I
A
A
R
KHMDKVV
Q
----
I
V
E
I
M
Q
Q
G
S
Q
---
L
-
P
----------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
38.79
27%
-16
- C2 -
-
5W1R
-
?
A:
[3719-4127]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
G
F
D
E
R
-
V
T
V
M
A
S
L
R
R
P
K
R
I
I
I
R
G
H
D
------
E
-
R
-
E
-
H
-
P
F
L
V
K
G
G
E
D
L
R
Q
D
Q
R
V
E
Q
L
F
Q
V
M
N
G
I
L
A
Q
D
S
A
C
S
Q
R
A
L
Q
L
R
T
Y
S
V
V
P
M
T
S
R
L
G
L
I
E
W
L
E
N
T
V
T
L
K
D
L
L
L
N
-----
T
M
--
S
--
Q
--
E
E
K
A
A
Y
L
S
D
P
R
A
P
P
C
E
Y
K
D
W
L
T
K
M
SGKHDVGAY
M
L
M
Y
K
G
A
N
R
T
E
T
V
T
S
F
R
K
R
E
S
K
-----
V
P
A
D
L
---
L
K
R
A
F
V
R
M
S
T
--
S
P
E
A
----
F
L
A
L
R
S
H
F
A
S
S
H
A
L
I
C
I
S
H
W
I
L
G
I
G
D
R
H
L
N
N
F
M
V
A
M
E
T
G
G
V
I
G
I
D
F
G
H
A
F
G
S
A
T
Q
F
L
P
V
P
E
L
M
P
F
R
L
T
R
Q
F
-----
I
N
L
M
L
P
---
M
--
K
-
E
T
------
G
L
M
Y
S
I
M
V
H
A
L
R
A
F
R
-------
S
DPG
L
L
T
N
T
M
D
V
F
V
K
---
E
-
P
S
F
D
W
----
K
N
F
E
Q
----
K
M
L
K
K
GGSWI
Q
E
I
N
V
AEKNWYP
R
Q
K
I
C
Y
A
K
R
-
K
L
-----------
A
G
A
N
P
A
V
I
T
C
D
E
L
L
----
L
G
H
E
K
A
P
A
F
R
D
Y
V
A
V
A
R
G
S
K
D
H
N
I
R
-
A
Q
E
P
E
S
G
L
S
----
E
E
T
Q
V
K
C
L
M
D
Q
A
T
D
P
N
I
L
G
R
T
W
E
G
W
E
P
W
-
62
Fugue
38.37
17%
-36
- C1 -
-
5L3T
-
THP1_YEAST
B:
[1-455]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
M
A
N
Q
L
L
D
E
L
A
H
G
N
F
S
H
L
T
L
N
L
S
Q
N
G
R
E
I
--
A
I
L
Q
K
Q
L
T
G
F
D
D
K
Q
L
E
T
F
V
E
Q
H
P
A
M
P
N
D
T
R
F
K
I
M
C
T
S
F
L
N
Y
A
R
D
-------
V
D
P
W
S
A
W
S
S
S
D
L
I
F
E
F
Y
Q
C
L
I
N
C
L
I
N
D
N
A
P
-------------
H
I
E
M
L
I
P
V
A
T
R
E
T
E
F
I
I
N
L
A
G
K
L
D
S
F
H
L
Q
L
H
T
R
S
--
H
Q
F
L
S
H
I
S
S
I
L
S
R
L
F
N
S
I
K
P
P
R
G
N
----
A
S
S
T
N
I
P
G
K
Q
R
I
L
L
Y
L
V
N
K
L
N
N
I
Y
F
R
I
E
---
S
P
Q
L
C
S
N
I
F
K
N
F
Q
P
K
S
M
L
A
H
F
N
E
Y
Q
L
D
Q
Q
I
E
Y
R
Y
L
L
G
R
Y
Y
L
L
N
S
Q
--------------
V
H
N
A
F
V
Q
F
N
E
A
F
Q
S
L
L
N
L
P
L
T
N
----------
Q
A
I
T
R
N
G
T
R
I
L
N
Y
M
I
P
T
G
L
I
L
GKM
V
K
W
G
P
L
R
P
F
L
S
Q
E
T
I
D
N
W
S
V
L
Y
K
H
V
R
Y
G
N
I
Q
G
V
S
L
W
L
R
Q
N
E
R
H
L
C
A
--------------------
R
Q
L
L
I
V
L
L
E
K
L
P
M
V
T
Y
R
N
L
I
K
T
V
I
K
S
W
T
T
E
W
G
Q
N
K
L
P
-------
Y
S
L
I
E
R
V
L
Q
L
S
I
G
P
T
F
E
D
P
G
A
Q
E
I
T
I
Y
N
G
I
H
S
P
K
N
V
E
N
V
L
V
T
L
I
N
--
L
G
L
L
R
A
N
C
F
P
Q
L
Q
L
C
V
V
K
-----
K
T
T
M
I
Q
E
I
V
P
P
V
N
E
R
I
T
K
M
F
P
A
H
S
H
V
L
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
38.11
21%
-55
- C2 -
-
2X6H
-
?
B:
[657-895]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
E
I
Y
I
T
K
I
V
P
M
R
T
S
L
F
K
S
A
L
M
P
A
K
L
T
F
V
T
-
S
------
I
A
H
-
H
-
E
Y
A
A
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
M
I
T
L
M
D
K
L
L
R
R
E
N
----
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
S
K
H
G
F
L
Q
Y
V
D
S
-
C
T
V
A
E
V
L
A
R
-----
E
G
----------
N
I
H
N
-----------------------------------------------------------------
F
F
R
K
H
H
P
--
C
D
N
G
PYGI
S
A
E
V
M
D
T
Y
I
K
S
C
A
G
Y
C
V
I
T
Y
L
L
G
V
G
D
R
H
L
D
N
L
L
L
T
-
T
N
G
K
L
F
H
I
D
F
G
Y
I
L
G
R
D
P
----
K
P
M
P
P
P
M
K
L
S
K
E
M
---
V
E
A
M
G
G
I
S
S--
E
H
H
H
-
E
F
------
R
K
Q
C
Y
T
A
Y
L
H
L
R
R
H
A
-------
N
----
V
M
L
N
L
F
S
L
M
V
D--
A
-
T
V
P
D
I
----
A
L
------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
37.65
34%
-130
- C2 -
-
3QK0
1
PK3CG_HUMAN
A:
[781-857]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
-
E
T
G
N
L
F
H
I
D
F
G
H
I
-----------
E
R
V
P
F
V
L
T
P
D
F
---
L
F
V
M
G
T
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
37.49
34%
-127
- C2 -
-
3QJZ
1
PK3CG_HUMAN
A:
[781-860]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
-
E
T
G
N
L
F
H
I
D
F
G
H
------------
E
R
V
P
F
V
L
T
P
D
F
---
L
F
V
M
G
T
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
37.48
21%
-49
- C2 -
-
2X6K
1
?
A:
[404-642]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
E
I
Y
I
T
K
I
V
P
M
R
T
S
L
F
K
S
A
L
M
P
A
K
L
T
F
V
T
-
S
------
I
A
H
-
H
-
E
Y
A
A
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
M
I
T
L
M
D
K
L
L
R
R
E
N
----
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
S
K
H
G
F
L
Q
Y
V
D
S
-
C
T
V
A
E
V
L
A
R
-----
E
G
----------
N
I
H
N
-----------------------------------------------------------------
F
F
R
K
H
H
P
--
C
D
N
G
PYGI
S
A
E
V
M
D
T
Y
I
K
S
C
A
G
Y
C
V
I
T
Y
L
L
G
V
G
D
R
H
L
D
N
L
L
L
T
-
T
N
G
K
L
F
H
I
D
F
G
Y
I
L
G
R
D
P
----
K
P
M
P
P
P
M
K
L
S
K
E
M
---
V
E
A
M
G
G
I
S
S--
E
H
H
H
-
E
F
------
R
K
Q
C
Y
T
A
Y
L
H
L
R
R
H
A
-------
N
----
V
M
L
N
L
F
S
L
M
V
D--
A
-
T
V
P
D
I
----
A
L
------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
37.17
28%
-132
- C2 -
-
5EUQ
1
PI4KB_BOVIN
E:
[375-491]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----
F
L
S
A
Q
R
N
F
V
Q
S
C
A
G
Y
C
L
V
C
Y
L
L
Q
V
K
D
R
H
N
G
N
I
L
L
D
-
A
E
G
H
I
I
H
I
D
F
G
F
I
L
S
S
S
P
-----------
K
L
T
T
E
F
---
V
D
V
M
G
G
L
D
---
G
--
D
-
M
F
------
N
Y
Y
K
M
L
M
L
Q
G
L
I
A
A
R
KHMDKVV
Q
----
I
V
E
I
M
Q
Q
G
S
Q
---
L
-
P
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