@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_36_3870: (2018-03-13 )
MSGASVRIPIEKYDIHDVFFSLSVLRKLPEYTRELEEGSSETLYRIIHSSICAARWYYRRYSRYGEFVHLLNTYAECIAVKSSNSALRVAELLAARTSQLHTPQLWQRLPLPIAASLLFAVICCTATVILIGIGEDCCRKADVAALILSCVSVLCLCALFPLIYASQRRRGYKGQERLVDRMVRMACDNAQSQNSFYNPLSDRIELTERVIVEDADAFLVDADIAHRNRRAIAMLLTEATEDEGSVVLRSRGLPPAMIGLNAIYRHTIIIMTDFDGKVVMWSDGAATCFGFSARDVEGNNIISLLYGERSVELYATMTEAAEKNLDLSEKVLTVAHMGLGTVSISATVVVSREAKSNQPVGFTLIGSVRSDELSQTQAVLHSFFVAELSQLSVKDSQFRQIVDCLRWKNLRDLSALARDWRSAHIRQLLSEVIKGRQRYVSVEVDPKVTELPPILCDTVGISAVLNRAFELFCEKIRVRVEQKRTTSAVYQLIVVYRHDMSGLNRNTLIDITRSANDLGGIVVDSPGTLKLLLPFMVKDEAIQALRPQGAAAQKPIGHDPLIVLLLEKNAVHRHNISASIWSCGHSLRLVENVRKALQAIEGSTDLGCAIIDVDVKGSDRVIEALLAKHIYIIETSEALDGGAKRGDALLKKPISNEALRKELEKATYKCEEAKRAGEELLKRREVFGKVRNSPWTQGRLLGRGGHAAVYEATSTLTGGKMAVKIIRVSGNFEERIDEFMNEIGILCKLTHPNIIHYFYCERTETTLNLFMAMADQGTVADLIKRCPRLPENHVATITKQLLQAVNYLHECGIIHRDIKPGNMLISQGQLKLSDFGTATTNVREGTVGTISYMAPEVVDGKPSGKESDIWSIGCVVCECLQIKRSGDGLLGYGAPEEYPSDVSAQAIDFIKACMQRNPSERATTGTLLLHDFIVHLDQEVSQLAEVLPEAAPNEEGAKTPKARSSFSDSTVISWSFD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720....---...730--.------.......740.......-750.......760.......770.......780..-...----.-.790.......800.......810........820...-.-.----.-.830......-----.----840-----.----....-..850......-----.------860.......870......------------------.880-....----.--------...--------.--------890---..---.--------------.------..------.----.--.900-....----...910.......920.......930.......940.......950.......960.......970.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSG
A
S
V
R
I
P
I
EKY
D
I
H
D
V
F
F
S
L
S
V
L
R
KL
P
E
Y
T
R
E
L
EEG
S
S
E
T
L
Y
R
I
I
H
S
S
I
C
A
A
R
W
Y
Y
R
R
Y
S
R
Y
G
E
F
V
H
L
L
N
T
Y
A
E
C
I
A
VKSSN
S
A
L
R
V
A
E
L
L
A
A
R
TSQLH
T
P
Q
L
W
Q
RLP
L
P
I
A
A
S
L
L
F
A
V
I
C
C
T
A
T
V
I
L
I
GI
G
E
D
C
C
R
K
A
D
V
A
A
L
I
L
S
C
V
S
V
L
C
L
C
A
L
F
P
L
I
Y
A
S
Q
RRRGYK
G
Q
E
R
L
V
D
R
M
V
R
M
ACDNAQSQNSFYN
P
L
S
D
R
I
E
L
T
E
R
V
I
VEDA
D
A
F
L
V
DA
D
I
AHRNR
R
A
I
A
M
L
L
TEATEDEG
S
V
V
L
RSRGL
P
P
A
M
I
G
L
N
A
I
Y
R
H
T
I
I
I
M
TDFDG
K
V
V
M
WSDGA
A
T
C
F
G
F
S
ARDVEGN
N
I
I
S
L
L
YGER
S
V
E
L
Y
A
T
M
T
E
A
A
EKNL
D
L
S
E
K
V
L
T
V
A
HMGL
G
T
V
S
I
S
A
T
V
V
V
S
REAKSNQP
V
G
F
T
L
I
GSVRS
D
E
L
S
Q
T
Q
A
V
L
H
S
F
F
V
A
E
L
S
QLSV
K
D
S
Q
F
R
Q
I
V
D
C
L
R
WKN
L
R
D
L
S
A
L
A
R
D
W
R
S
A
H
I
R
Q
L
L
S
E
V
I
KGR
Q
R
Y
V
S
V
EVDPKVTELP
P
I
L
C
D
T
V
G
I
S
A
V
L
N
R
A
F
E
L
F
C
E
K
I
R
V
R
V
EQK
R
T
T
S
A
V
Y
Q
L
I
V
V
Y
RHDMSGLNRN
T
L
I
D
I
TRSANDL
G
G
I
V
VDSPG
T
L
K
L
L
L
P
F
M
V
K
D
E
A
I
Q
A
LRPQGAAAQKPIGHD
P
L
I
V
L
L
LEKNAVHRHNI
S
A
S
I
W
SCG
H
S
L
R
L
V
E
N
V
R
K
A
L
Q
A
IEGSTDL
G
C
A
I
I
D
V
DVKGS
D
R
V
I
E
A
L
L
AK
H
I
Y
I
I
ETSEALDGGAKR
G
D
A
L
L
KKPIS
N
E
A
L
R
K
E
L
E
K
A
T
Y
K
C
E
E
A
K
R
A
G
E
E
L
L
K
R
R
E
V
F
G
K
VRNSPWTQG
R
L
LGRGG
H
A
A
V
Y
E
ATSTLTGG
K
M
A
V
K
I
I
---
R
VSG
N
---
F
------
E
E
R
I
D
E
F
M
N
EIG
I
L
C
KL-THP
N
I
I
H
Y
F
Y
CERT
E
T
T
L
N
L
F
M
A
MADQG
T
V
A
D
L
I
K
-RCP----R-LP
E
N
H
V
A
T
I
T
K
Q
L
L
Q
A
V
N
Y
L
H
E-CGIIHRDIKPG
N
M
L
I
-S-Q----G-
Q
L
K
L
SDFGTA-----T----TNV-----R----EG
T
V
-
G
T
I
S
YMAPEVV-----D------GKPSGKESD
I
W
S
I
G
C
V
V
C
E
------------------
C
L
---
Q
I
KR----S--------GDG--------L--------L-----GY---G--------------A------PE------E----Y--PSDV-
S
A
Q
A
----
I
D
F
I
K
A
C
M
QRNPSERAT
T
G
T
L
L
L
H
D
F
I
V
H
L
D
Q
E
V
S
Q
L
A
E
VLPEAAPNEEGAKTPKARSSFSD
S
T
V
I
S
W
SFD
13
PsiBlast_PDB
81.69
29%
-76
- C1 -
-
3SLS
2
MP2K1_HUMAN
A:
[10-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
---
H
L
E
I
K
---
P
------
A
I
R
-
N
Q
I
I
R
E
L
Q
V
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
-
K
A
G
----
R
-
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
----
G
-
E
I
K
L
C
D
F
G
V
S
GQL--
I
-------------------
F
V
-
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
------
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
-------------------
M
---
A
V
G
R
YPIG------------A
I
F
E
----
L
--------
L
-----
D
Y
I
V
N
E
--------------
P
------
P
P
------
K
----
L
--
P
S
G
V
F
S
L
E
F
----
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
--------------------------------------
6
PsiBlast_PDB
81.25
31%
-73
- C1 -
-
4AOT
1
STK10_HUMAN
A:
[18-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
---
E
T
K
S
-----------
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-
E
L
D
----
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
----
G
-
D
I
R
L
A
D
F
G
V
S
-----
A
----------------------
G
T
P
Y
W
M
A
P
E
V
V
M--------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
------------------
M
A
---
Q
I
E
P
----
P
--------
H
H
E
--------
L
NPMR
V
L
L
K
I
-----
A
K
---
S
--------------
D
------
P
P
------
T
----
L
LT
P
S
K
W
-
S
V
E
F
----
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--------------------------------------------
9
PsiBlast_PDB
77.61
31%
-63
- C1 -
-
5AJQ
2
STK10_HUMAN
A:
[15-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
---
E
--------------
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-
E
L
D
----
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
----
G
-
D
I
R
L
A
D
F
G
V
S
-----
A
----
K
N
L
K
T----------
F
I
-
G
T
P
Y
W
M
A
P
E
V
V
MCETM
K
------
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
------------------
M
A
---
Q
I
E
P
----
P
--------
H
H
E
--------
L
N
P
M
R
V
L
L
K
I
-----
A
K
---
S
--------------
D
------
P
P
------
T
----
L
LT
P
S
K
W
-
S
V
E
F
----
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--------------------------------------------
8
PsiBlast_PDB
77.58
31%
-64
- C1 -
-
4USE
1
STK10_HUMAN
A:
[18-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
---
E
T
K
S
-----------
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-
E
L
D
----
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
----
G
-
D
I
R
L
A
D
F
G
V
S
-----
A
----
K
N
L
KTLQ------------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
------
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
------------------
M
A
---
Q
I
E
P
----
P
--------
H
H
E
--------
L
N
P
M
R
V
L
L
K
I
-----
A
K
---
S
--------------
D
------
P
P
------
T
----
L
LT
P
S
K
W
-
S
V
E
F
----
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--------------------------------------------
4
PsiBlast_PDB
77.37
33%
-60
- C1 -
-
2JFL
6
SLK_HUMAN
A:
[45-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
---
D
T
K
S
-----------
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-
E
L
E
----
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
----
G
-
D
I
K
L
A
D
F
G
V
S
-----
A
----
K
N
T
RTIQR
R
----
D
S
F
I
-
G
T
P
Y
W
M
A
P
E
V
V
MCETS
K
------
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
------------------
M
A
---
E
I
E
P
----
P
--------
H
H
E
--------
L
NP
M
R
V
L
L
K
I
-----
A
K
---
S
--------------
E
------
P
P
------
T
----
L
AQ
P
S
R
W
-
S
S
N
F
----
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
--------------------------------------------
3
PsiBlast_PDB
76.69
33%
-59
- C1 -
-
2J51
5
SLK_HUMAN
A:
[45-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
---
D
T
K
S
-----------
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-
E
L
E
----
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
----
G
-
D
I
K
L
A
D
F
G
V
S
-----
A
----
K
N
T
R
T
I
Q
R
R
----
D
S
F
I
-
G
T
P
Y
W
M
A
P
E
V
V
M
CETS
K
------
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
------------------
M
A
---
E
I
E
P
----
P
--------
H
H
E
--------
L
NPMR
V
L
L
K
I
-----
A
K
---
S
--------------
E
------
P
P
------
T
----
L
AQ
P
S
R
W
-
S
S
N
F
----
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
--------------------------------------------
2
PsiBlast_PDB
76.15
33%
-55
- C1 -
-
2JFM
2
SLK_HUMAN
A:
[45-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
---
D
T
K
S
-----------
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-
E
L
E
----
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
----
G
-
D
I
K
L
A
D
F
G
V
S
-----
A
----
K
N
T
RTIQR
R
----
D
S
F
I
-
G
T
P
Y
W
M
A
P
E
V
V
MCETS
K
------
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
------------------
M
A
---
E
I
E
P
----
P
--------
H
H
E
--------
L
NPM
R
V
L
L
K
I
-----
A
K
---
S
--------------
E
------
P
P
------
T
----
L
AQ
P
S
R
W
-
S
S
N
F
----
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
--------------------------------------------
11
PsiBlast_PDB
75.23
31%
-65
- C1 -
-
4BC6
2
STK10_HUMAN
A:
[10-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
---
E
T
K
S
-----------
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-
E
L
D
----
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
----
G
-
D
I
R
L
A
D
F
G
V
S
-----
A
----
K
N
L
K
T
L
Q-------------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
------
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
------------------
M
A
---
Q
I
E
P
----
P
--------
H
H
E
--------
L
NPMR
V
L
L
K
I
-----
A
K
---
S
--------------
D
------
P
P
------
T
----
L
LT
P
S
K
W
-
S
V
E
F
----
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--------------------------------------------
44
HHSearch
74.75
28%
-88
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
---
K
L
E
P
G
-----------
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
-
V
T
G
----
P
-
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
-
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
-
T
-
D
N---
G
-
H
V
K
L
A
D
F
G
V
S
-----
A
----
Q
I
T
-----
A
TIA--
A
F
I
-
G
T
P
Y
W
M
A
P
E
V
A
-----
A
V
ER---
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
------------------
L
A
---
E
L
Q
P
----
P
--------
M
F
D
--------
L
--------
H
P
M
R
A
L
F
L
---
M
TKS
N
F
---------
Q
------
P
P
KL----
K
----
D
--
K
M
K
W
-
S
N
S
F
----
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
L
T
R
--------------------------------------
18
PsiBlast_PDB
73.45
32%
-39
- C1 -
-
5DH3
1
STK3_HUMAN
A:
[35-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
S
Y
G
S
V
F
K
A
I
H
K
E
S
G
Q
V
V
A
I
K
Q
V
---
P
V
-------------
E
S
D
L
Q
E
I
I
K
E
I
S
I
M
Q
Q
C
-
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
N
T
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
I
I
R
L
R
N
K
----
T
-
L
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
-
M
R
K
I
H
R
D
I
K
A
G
N
I
L
L
N
T
-
E
----
G
-
H
A
K
L
A
D
F
G
V
A
G
Q
L
TD
T
----
M
A
K
-----
R
----
N
T
V
I
-
G
T
P
F
W
M
A
P
E
V
I
-----
Q
------
E
I
G
Y
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
------------------
M
A
---
E
G
K
P
----
P
YAD
I
H
P
M
R
A
I
F
--------
M
--------
I
-----
P
T
---
N
--------------
P
------
P
P
------
T
----
F
RK
P
E
L
W
-
S
D
D
F
----
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
I
K
N
A
-
K
P
V
S
I
L
R
D
L
I
T
E
A
---------------------------
1
PsiBlast_PDB
73.17
33%
-59
- C1 -
-
4USF
1
SLK_HUMAN
A:
[24-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
---
D
T
K
S
-----------
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-
E
L
E
----
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
----
G
-
D
I
K
L
A
D
F
G
V
S
-----
A
----
K
------------------
T
P
Y
W
M
A
P
E
V
V
M
C
E----------
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
------------------
M
A
---
E
I
E
P
----
P
--------
H
H
E
--------
L
NPMR
V
L
L
K
I
-----
A
K
---
S
--------------
E
------
P
P
------
T
----
L
AQ
P
S
R
W
-
S
S
N
F
----
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
--------------------------------------------
14
PsiBlast_PDB
72.31
32%
-47
- C1 -
-
2XIK
2
STK25_HUMAN
A:
[27-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
---
D
L
E
E
A
---
E
-------
E
I
E
D
I
-
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
-
P
G
P
------
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
----
G
-
D
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
----
Q
I
K
-----
R
----
N
T
F
V
-
G
T
P
F
W
M
A
P
E
V
I
-----
K
------
Q
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
------------------
L
A
---
K
G
E
P
----
P
--------
N
S
D
--------
L
H
P
M
R
----
V
-----
L
F
---
L
--------------
I
------
P
K
------
N
----
S
--
P
P
T
L
-
E
G
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
------------------------------
10
PsiBlast_PDB
71.97
32%
-12
- C1 -
-
4B6L
1
PLK3_HUMAN
A:
[11-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
K
G
R
L
L
G
K
G
G
F
A
R
C
Y
E
A
T
D
T
E
T
G
S
A
Y
A
V
K
V
I
P
QS
R
V
A
K
P
---
H
------
Q
R
--
E
K
I
L
N
E
I
E
L
H
R
D
L
-
Q
H
R
H
I
V
R
F
S
H
H
F
E
D
A
D
N
I
Y
I
F
L
E
L
C
S
R
K
S
L
A
H
I
W
K
-
A
R
H
----
T
-
L
L
E
P
E
V
R
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
-
R
G
I
L
H
R
D
L
K
L
G
N
F
F
I
-
T
-
E
----
N
M
E
L
K
V
G
D
F
G
L
A
-----
A
RLEP
P
E
Q
-----
R
----
K
K
T
I
C
G
T
P
N
Y
V
A
P
E
V
L
-----
L
------
R
Q
G
H
G
P
E
A
D
V
W
S
L
G
C
V
M
Y
T
------------------
L
L
C
GS
P
P
F
E
----
T
--------
A
D
L
--------
K
--------
E
-----
T
Y
---
R
--------------
C
------
I
K
------
Q
V
H
Y
T
L
--
P
A
S
L
-
S
L
P
A
----
R
Q
L
L
A
A
I
L
R
A
S
P
R
D
R
P
S
I
D
Q
I
L
R
H
D
F
F
T
-------------------------------------------
39
HHSearch
71.35
29%
10
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[93-365]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
---
E
V
------
R
LSPEQL
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
-
E
K
V
----
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
-
D
-
D
N---
M
-
Q
I
R
L
S
D
F
G
F
S
-----
C
----
H
L
E
-----
P
GEKL
R
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
-----
K
CSMDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
------------------
L
L
---
A
G
S
P
----
P
--------
F
W
H
--------
R
--------
R
QILML
R
M
---
I
--------------
M
------
E
G
QYQFSS
P
----
E
--
W
D
D
R
-
S
S
T
V
----
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
R
------------------------------------------
5
PsiBlast_PDB
71.33
31%
-56
- C1 -
-
2J7T
1
STK10_HUMAN
A:
[18-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
---
E
---------------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-
E
L
D
----
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
----
G
-
D
I
R
L
A
D
F
G
V
S
-----
A
----
K
N
L
K
T
L
Q
K----------
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
------
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
------------------
M
A
---
Q
I
E
P
----
P
--------
H
H
E
--------
L
N
P
M
R
V
L
L
K
I
-----
A
K
---
S
--------------
D
------
P
P
------
T
----
L
LT
P
S
K
W
-
S
V
E
F
----
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--------------------------------------------
20
PsiBlast_PDB
71.08
26%
-78
- C1 -
-
5KKR
-
MP2K1_RABIT
C:
[43-369]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
D
E
Q
Q
R
K
R
L
-
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
---
H
L
E
I
K
---
P
------
A
I
R
-
N
Q
I
I
R
E
L
Q
V
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
-
K
A
G
----
R
-
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
----
G
-
E
I
K
L
C
D
F
G
V
S
GQL--
I
----
D
S
M
-----
A
----
N
S
F
V
-
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
------
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
MAVGRYPIPPPDAKELEL
M
F
---
G
C
-----------------------------------------------PMAIFELLDYIVNE
P
------
P
P
------
K
----
L
--
P
S
A
V
F
S
L
E
F
----
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
--------------------------------------
7
PsiBlast_PDB
69.62
31%
-65
- C1 -
-
4EQU
2
STK10_HUMAN
A:
[18-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
---
E
-----------------
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-
E
L
D
----
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
----
G
-
D
I
R
L
A
D
F
G
V
S
-----
A
----
K
N
L
-------------
I
-
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
------
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
------------------
M
A
---
Q
I
E
P
----
P
--------
H
H
E
--------
L
N
P
M
R
V
L
L
K
I
-----
A
K
---
S
--------------
D
------
P
P
------
T
----
L
LT
P
S
K
W
-
S
V
E
F
----
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--------------------------------------------
31
HHSearch
69.37
27%
-51
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[23-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
---
D
V
A
K
F
T
S
S
P
------
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
-
K
R
A
D
A
G
F
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
-
A
-
S
KENS
A
-
P
V
K
L
G
G
F
G
V
A
-----
I
----
Q
L
G
ESG
L
V
A
----
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
-----
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
------------------
L
L
---
S
G
C
L
----
P
--------
F
Y
G
--------
T
K
E
R
L
----
F
-----
E
G
---
I
--------------
I
K
GKYKM
N
P
------
R
----
Q
--
W
S
H
I
-
S
E
S
A
----
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
-------------------------------------
12
PsiBlast_PDB
69.37
32%
-38
- C1 -
-
4LGD
1
STK3_HUMAN
A:
[34-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
S
Y
G
S
V
F
K
A
I
H
K
E
S
G
Q
V
V
A
I
K
Q
V
---
P
V
E
S
D
---
L
------
Q
E
I
I
----
K
E
I
S
I
M
Q
Q
C
-
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
N
T
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
I
I
R
L
R
N
K
----
T
-
L
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
-
M
R
K
I
H
R
N
I
K
A
G
N
I
L
L
N
T
-
E
----
G
-
H
A
K
L
A
D
F
G
V
A
GQLTD
T
----
M
A
K
-----
R
----
N
T
V
I
-
G
T
P
F
W
M
A
P
E
V
I
-----
Q
------
E
I
G
Y
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
------------------
M
A
---
E
G
K
P
----
P
--------
Y
A
D
IH
P
M
R
A
I
F
M
--------
I
-----
P
T
---
N
--------------
P
------
P
P
------
T
----
F
RK
P
E
L
W
-
S
D
D
F
----
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
I
K
N
A
-
K
P
V
S
I
L
R
D
L
I
T
E
A
---------------------------
38
HHSearch
68.69
29%
6
* C1 *
-
2Y7J
1
PHKG2_HUMAN
C:
[93-364]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
---
E
V
T
A
E
---
R
LSPEQL
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
-
E
K
V
----
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
-
D
-
D
N---
M
-
Q
I
R
L
S
D
F
G
F
S
-----
C
----
H
L
E
-----
P
GEKL
R
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
-----
K
CSMDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
------------------
L
L
---
A
G
S
P
----
P
--------
F
W
H
--------
R
--------
R
QILML
R
M
---
I
--------------
M
------
E
G
QYQFSS
P
----
E
--
W
D
D
R
-
S
S
T
V
----
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-------------------------------------------