@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_36_4770: (2018-03-13 )
MEKESLEAPNSANGSFSVVNHDLVKPSDARSKTNSNATASATRPSRDRADSVRVSRQHMYVDIDQVGFCNDATSMVWVPNTGGPTSSLRTNDKASSTKGGDGFAVPSSQTRIPAIALAGYVRSSIVGDAAPVIVRGHKYVFNNSTRRWLAHPITVRVLHHNRGIHQDKYFATFAMELLDPVKPATPMLAKVYRHNIDLVSETDYYSLGQAQALCEEFAREYTCTAARSHYVKFHLPLLTNRVVVRLDMDSVLDPAVRTARKGFFSYRTQDTRQVMFFMEPNTVACEALGISFASREVDEGKCYSRGDAMWSRDIYRDIADGFSHFTYVRSRACMVAHGFVRSNGYLLDPLFHTTDSERFTMGDAGRSAMEDWVKRHRCGDTCRALGISNFNNDGERVKKAAACVNPLDMEENHYTDYLRSVRQMRVIVHMDAAQILCDYKKDSAVDTVSESSDFTPTMAALQPMPISSVSRKVTCDAVKYVFLPTRAKWMEVPMRLTVAASAVPDTVDGTYAFFAIEEVREGGRPVPMRARFLLRPEARDADYYHFGDAYCVCVTLGQVFREYCANNVFARDLDFYAAYAVRVPQANIPDYIKAAMHDSDFFARTTADSGDVMFVAEAEFQPFSPRCLPNADGVSKDAEGFDDLALRNVVDAFSHFTLHKSGNHLLVCQFKCQDGLLMHPNINTSSGCGFETLNDGQAGIDAWVRKHTCNEVCKFLGMEPLPRQLKLYDISSSPLMRYIRHMQEHKMDSDEMLELAPPSRRMSDRMLPAASDAAASQSERARASSSATASTATAAVASFVRPTPPNSEETMLRPWVKRGCKASAASAKGTAAQRRTLTQRELMRLQSKGIDTKYIIPATRYDLNIDDLTWTSKRIFVRIVNPERGIGQGGMRVCFEITDVDPDACAESVMVAKMYRRTIKNVVEKDYFASVMVQKLSSLFAKDFNKERNEDGPLLLNVLDGAVIALDRADLHPELLAQRTGFFSYRTEDTERVVFCVEQRLLGRFTKYNGNMGEAYPTNECRLSPPAARERTMVFEAVEALSHYSLERSEGGLLVCDMQGVRNDLTDLEVHSYDGQSLDIGNFGARGIQKFALRHRCTSVCKSLNLRNLRDRHFTVTDDVKTKNRFVALFERIKEIGNMEE
Atome Classification :
(20 SA)
--------.........------10......------..20.....----...30........40......-------..50.....----...-----60........70........80........90........100.......110----......-.120..------..--...130..--..----...140.......150-------........160.---...----------------...170.----....----..180------------------------------.........190.....-.---------.200.------------------------.....---.210.......220......----.230.......240-.........---250.......260.----------......--270---.........280.......290.....-----.----.300-......---.-..310.......-------320.......330.......340..----....----------------.350---....-----.--..360..-------....----.370...-----....-380.....---..390.......400.......410.......420.......430.......440---------........----.450..----.....460.......470.......480.......490...---....500.......510.-------......---520.......--530.......540.......550---........560.......570.......580.....--..590.......600......-----.610....------------------...620.......630.---------......640.......650....----...660----.........670...---....-680.......690.......700.......710.......--------------720------------.......--730.....------..740.......750.......760.......770......--------...780------------........790.......800.......810..------------------.....820......---.830.....-..840..------.-....850.......860---.......870.......880------......-.890.......900--..-------------------------------..---....910.......920---------.....-...930.......940.......950.......960....-..--.970.......980.----------.....-----.990.......1000......1010......1020......1030......1040......1050......1060----...---...1070-....-----.--...-----1080......1090---........1100......1110......1120......1130......1140
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------MEKESLEAP------NSANG
S
F
S
------
V
V
NHDLVKP----SDARSKTNSNATASATRPSRD-------RADS
V
R
V
S
R
----
Q
H
M
-----
Y
V
D
IDQVGFCNDAT
S
M
V
W
VPNTGGPTSSLRTNDKASSTKGGDGFAVPSSQTRI----P
A
I
A
L
A
-
G
Y
V
R
S
S
------IV--GDAA
P
V
I
V
--RG----
H
K
Y
V
FNNSTRRWLAH--------
P
I
T
V
R
V
L
HHNRG---IH
Q
----------------
D
K
Y
F
A
T
F
----
A
M
E
L
----LDP--------------------------------VKPA
T
P
M
L
A
K
V
Y
R
HNID-L---------VSETD------------------------YYSLG---
Q
A
Q
A
L
C
E
E
F
A
R
EYT
C
T
A
A
RS----
H
Y
V
K
F
H
LPLLT
N
---
R
V
V
V
R
L
D
M
D
---
S
VL
D
P
A
V
R
T
A
R
K
G
F
----------
F
SYRTQ--D-----
T
R
Q
V
M
F
F
MEPN
T
V
A
C
E
A
LG
I
S
F
ASREV-----D----EG---KCYSRG---D-
A
M
W
S
R
D
I
Y
R
D
I
A
-------
D
G
F
S
H
F
T
Y
V
R
S
R
A
C
M
V
A
H
G
F
VRSN
G
----
Y
L
LD----------------PLFH---TTDS-----E--
R
F
TMGDA-------
G
R
S
A
----
M
E
D
W
V
K
R
-----HRCG-
D
T
C
R
A
LGI---SNFNN
D
G
E
R
V
K
K
A
A
ACVNPLDMEE
N
H
Y
T
D
Y
L
R
S
V
R
Q
M
R
V
I
V
H
M
D
A
A
Q
I
L
C
DYK-----------KDSAVDTV----SESSDF----TP
T
M
A
ALQPMPI
S
S
VS
R
K
V
T
C
D
A
V
K
Y
V
F
LPTR
A
K
W
MEV
P
M
R
---
L
T
V
AASAVPDTVDGT
Y
A
F
-------
F
A
I
E
E
V
---REGGRPVP
M
R
--
A
R
F
L
LRPEARDAD
Y
Y
HFGD
A
Y
C
----
V
C
V
T
L
G
Q
V
F
R
E
Y
CANNV
F
A
R
D
L
D
F
Y
A
A
Y
AVRVPQAN--
I
P
D
Y
I
K
A
A
MHDSD
F
F
A
RTTAD-----SG
D
V
M
F
V
A------------------EAEFQPFSPRCLPNADG---------VSKDAEG
F
D
D
L
A
L
R
N
V
V
D
A
F
S
H
F
----
T
LHK------SG
N
H
L
L
V
C
Q
F
KCQD
G
---
L
L
MH-PNINTSSGCGFETLNDG
Q
A
G
I
D
A
W
V
R
KH
T
C
N
E
V
C
K
F
LGME--------------PLP------------
R
Q
L
K
L
Y
D--IS
S
S
P
L
M
R
------
Y
I
R
H
M
Q
E
HKM
D
S
D
E
M
L
ELAPPSRRMSDRMLPAA--SDAAA
S
--------
Q
S
E
R
A-------------RASSSATA
S
T
A
T
A
A
V
A
S
F
VRPTPPNS
E
E
T
M
L
R
P
------------------
W
V
KRGCKASAASAK---G
T
A
A
Q
R
RTL-
T
Q
R
E
L
M
R
------
L
-
Q
SKGID
T
K
Y
I
I
P
A
T
R
Y
D---LNIDDLTWTS
K
R
I
F
V
R
I
VNP------ERGIGQ-G
G
M
R
V
C
F
E
ITDV
D
---
P
D
-------------------------------
A
C
---
A
E
S
V
M
V
A
K
M
Y
R
R
T
I
K
-
N
---------
V
V
E
K
D
-
Y
F
A
S
V
M
V
Q
K
L
S
S
L
F
A
K
D
F
NKERNEDG
P
L
L
L
N
VLD
G
A
V
I
A
L
-DR--ADL
H
P
E
L
L
A
Q
RTG
F
F
----------
S
YRTE-----DT
E
R
V
V
F
C
V
E
Q
R
L
L
G
R
F
T
KYNGNMGEAYPTNECRLSPPAA
R
E
R
T
M
V
F
E
A
V
E
A
L
S
H
YSLERSEG
G
L
L
V
C
DMQGVRN----DLT---D
L
E
V
H---SYDG-----Q--SLD-----IGN
F
G
A
R
G
I
Q
K
F
-----
A
L
R
H
R
C
T
S
V
C
K
SLNLRNLRDR
H
F
T
VTDDVKTK
N
R
F
V
A
L
F
E
R
I
K
E
IGNMEE-
37
Fugue
48.90
17%
14
- C1 -
-
4IGL
2
?
A:
[7-1485]
-------E
M
A
I
T
T
L
S
L
P
KGGG
A
I
N
G
M
G
E
S
V
G
QAGPDG
M
V
T
F
S
I
P
L
P
----
F
S
A
G
R
G
V
A
P
A
L
S
L
S
Y
S
S
G
A
G
N
GPFGMG
W
Q
C
S
A
M
S
I
S
R
----
R
T
Q
KGVPQ
Y
N
E
D
D
E
--
F
L
S
P
S
G
E
V
M
A
I
A
L
N
D
S
G
F
E
D
V
R
T
A
N
R
L
Q
G
I
P
L
P
F
S
Y
K
V
T
R
Y
Q
P
R
L
IQDF
I
K
I
E
Y
W
-
Q
P
V
K
Q
T
D
G
T
P
F
W
I
I
Y
S
P
D
G
Q
T
H
I
L
GK
N
S
----
H
S
R
V
A
N
A
E
N
P
S
Q
I
A
S
WLLE
E
T
V
T
P
T
G
E
H
I
Y
Y
Q
Y
S
G
---
E
N
Q
VNCT
D
A
E
I
A
L
H
PQDSA
Q
R
Y
L
A
R
I
----
D
Y
G
N
----
I
S
P
QASLFV--------------------------
L
D
E
E
L
P
N
L
T
Q
W
L
F
H
L
V
F
-
D
---------
Y
G
E
R
D
ISIN
K
I
P
T
FEGGTT
G
W
L
A
R
PD
M
F
S
R
Y
D
F
G
I
E
I
R
N
R
R
L
C
H
Q
V
L
G
F
H
R
L
E
A
L
N
D
----
R
D
V
T
D
E
I
P
V
L
V
N
---
R
L
T
L
D
Y
D
L
N
NSV
S
T
L
V
A
V
R
Q
V
A
Y
E
T
D
G
S
P
I
T
Q
PPL
E
F
D
Y
Q
R
F
--
D
-----
T
G
S
I
P
G
W
Q
E
M
P
Q
L
E
A
F
N
G
Y
Q
P
Y
Q
M
I
D
L
-----
Y
GEG
T
P
G
---
I
L
Y
Q
E
T
---
P
G
A
W
W
Y
K
S
P
Q
R
Q
I
G
-------
G
D
S
N
A
V
T
Y
G
A
M
K
A
--
L
P
K
I
P
R
L
E
G
A
----
T
L
M
D
I
NGDGRLD
W
V
I
T
S
A
G
V
R
G
F
H
---
S
I
E
W
-----
T
--
H
F
T
P
L
N
T
LPTEYFH
P
K
A
Q
----
L
A
D
L
V
G
A
GLS
D
L
V
L
I
G
P
K
S
V
R
L
Y
A
N
---
Q
N
V
S
L
P
V
I
G
S
R
Q
L
V
A
F
A
D
M
L
G
S
G
Q
Q
H
L
V
E
I
--
T
A
D
S
V
K
C
W
P
N
M
G
H
G
R
F
G
Q
P
L
T
L
E
GFSQPQTSF
N
P
D
R
V
F
L
A
DIDG
S
G
T
N
D
I
I
Y
A
H
S
E
C
L
E
I
Y
L
N
E
S
G
N
R
F
S
K
P
I
S
L
L
L
P
D
G
V
N
F
D
N
T
C
Q
L
Q
A
A
D
I
Q
GLG
I
A
S
L
V
M
T
V
P
H
M
S
P
T
H
W
R
C
D
LALNKP
W
L
L
N
V
M
N
NN
R
G
A
E
T
C
L
F
Y
R
S
S
A
Q
F
W
L
D
E
K
Q
L
V
E
A
A
G
Q
Q
P
E
C
H
L
P
F
P
M
H
L
H
W
R
S
E
I
F
D
E
I
T
G
N
R
L
--
T
Q
E
Q
E
Y
A
H
G
S
W
D
G
Q
E
R
E
--
F
R
G
F
G
R
L
I
Q
R
D
T
D
G
F
A
Q
G
T
V
D
IP
T
H
P
S
R
T
V
S
W
F
A
TGI
P
E
I
D
T
T
LSAEFWRGD
D
Q
A
F
S
P
F
S
P
R
F
T
R
W
E
D
S
EA
G
S
D
V
A
F
I
P
S
E
H
D
A
F
W
L
N
R
A
M
K
G
Q
L
L
R
S
E
L
Y
G
DDG
T
P
E
A
EIPY
S
V
T
E
M
R
H
Q
V
R
A
L
P
T
T
D
A
T
V
P
S
A
W
C
-
S
T
I
E
T
R
S
Y
Q
Y
Q
R
V
A
A
D
P
Q
C
S
Q
Q
V
V
I
K
A
D
R
Y
G
S
P
L
L
S
V
A
I
N
Y
P
R
RKKPEKSPYPD
D
L
P
ET
L
F
D
S
S
YDTQQ
Q
Q
L
H
L
T
K
--
Q
Q
Q
N
Y
F
H
L
TNDD
N
W
L
L
G
L
P
K
E
Q
R
N
D
G
Y
Q
Y
D
Q
E
R
A
P
A
N
G
F
T
L
E
T
L
I
A
S
--
N
S
L
I
G
S
N
Q
P
F
T
Y
L
G
Q
S
R
V
A
Y
Q
GGVDEQPSLQA
L
V
A
Y
G
E
T
A
I
L
D
E
K
T
L
Q
A
F
V
G
V
L
D
S
K
T
R
D
E
L
L
F
S
A
G
Y
Q
L
A
P
RLFRVESE
P
D
V
W
V
A
R
Q
G
Y
S
E
F
G
D
Y
S
QFW
R
P
L
S
Q
R
S
T
L
L
T
G
K
T
T
L
K
W
D
KHYC
V
-
V
I
E
T
Q
D
A
A
Q
L
V
T
Q
A
R
Y
D
YRF
L
T
P
Y
S
L
T
D
A
N
D
N
Q
H
Y
V
V
L
N
P
FGEVI
A
S
R
F
W
G
T
E
A
G
K
D
A
G
Y
S
T
P
Q
A
K
---
P
F
-------------------------------
V
V
---
P
A
T
I
E
A
A
L
A
L
S
P
G
I
P
-
V
---------
A
H
C
A
I
-
F
E
P
E
S
W
M
Q
K
L
T
---
Q
H
D
V
S
E
R
M
A
D
N
G
T
L
W
N
A
L
L
Q
A
R
F
V
T
E
-
D
G
Y
V
C
A
L
G
R
R
R
W
M
A
R
H
G
L
S
----------
V
L
M
L
T
-----
L
L
A
E
I
P
R
T
P
P
H
S
L
T
I
T
T
D
R
Y
D
S
D
-
D
Q
Q
Q
L
R
Q
R
I
L
F
S
D
G
F
G
R
---
L
L
Q
S
A
Q
R
V
E
A
G
E
S
W
Q
R
S
E
D
S
S
L
V
V
N
V
S
G
T
P
A
----
L
V
V
T
DN
R
W
A
V
S
G
R
T
E
Y
D
G
-----
K
--
G
Q
G
-----
I
R
V
Y
Q
P
Y
F
L
D
D
W
RYLS
D
D
S
A
R
T
D
L
F
A
D
T
H
I
Y
D
P
L
G
R
E
Y
Q
V
I
T
A
K
G
Y
R
R
E
R
Q
Y
T
P
W
F
V
V
N
Q
D
E
N
D
T
A
A
N
36
Fugue
45.80
16%
-0
* C2 *
-
3UGM
-
PTHX1_XANOP
A:
[169-1048]
KPKVRELV
A
H
I
V
A
L
S
Q
H
------
P
A
A
L
G
T
V
A
------
V
T
Y
Q
H
I
I
T
A
LAT
H
E
D
I
V
G
V
G
K
Q
W
S
G
A
R
A
L
E
A
L
L
T
-------
D
A
G
E
L
R
G
P
P
LQLD
T
G
Q
-----
L
V
K
I
A
K
R
G
G
V
T
A
M
E
A
V
H
A
S
R
N
A
L
T
P
L
N
L
T
P
A
Q
V
V
A
I
A
S
N
N
G
G
K
Q
A
L
E
T
V
Q
R
L
L
----
P
V
L
C
Q
A
H
G
L
T
P
A
Q
------
V
V
--
A
I
A
S
----------------
H
D
G
G
K
Q
A
L
E
T
M
--------
Q
R
L
L
P
V
L
C
Q
A
H
G
---
L
P
P
----------------
D
Q
V
V
A
I
A
SNIG
G
K
Q
A
----
L
E
T
--------------------------------
V
Q
R
L
L
P
V
L
C
Q
A
H
G
L
T
P
D
-
Q
---------
V
V
A
I
A
------------------------
S
H
--
G
---
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
----
G
--------
L
T
P
---
D
Q
V
V
A
I
A
S
H
---
D
G
G
K
Q
A
L
E
T
V
Q
R
L
L
----------
P
V
L
C
Q
A
--
H
-----
G
------
L
T
P
D
Q
V
V
A
I
A
----------------------------
S
N
G
---
G
-
G
K
Q
A
L
E
T
V
Q
R
L
L
-------
P
V
L
C
Q
-----------
A
H
G
L
-------------------------------------
T
P
D
-----
Q
--
V
V
A
I
A
S
N
-------
G
G
K
Q
----
A
L
E
T
V
Q
R
------
L
L
P
-
V
L
C
Q
A
H
G
L
---
T
-----
P
D
Q
V
V
A
I
A
S
H
----
D
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
T
H
G
L
T
P
A
Q
V
V
A
I
A
S
-----------
H
D
G
G
K
Q
A
L
----
E
T
V
Q
Q
L
----
L
P
V
L
C
Q
A
H
G
L
T
---------------------------
P
D
Q
---
V
V
A
I
A
S
----
N
I
G
G
K
Q
A
L
-------
A
T
V
Q
R
L
--------
L
P
V
L
C
--
Q
A
H
G
L
T
P
-------------------------
D
Q
V
V
A
I
A
S
N
G
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
GL
T
P
D
Q
V
V
A
I
A
--------
S
N
G
G
-----
G
K
Q
A
L
E
T
V
------------------
Q
R
L
L
------------
P
---------
V
L
C
Q
A
H
G
L
T
Q
V
Q
V
V
A
I
A
S
-----------
N
I
------
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
---
L
C
Q
A
-
H
G
L
T
P
A
Q
V
V
A
I
A
S
H
D
G
G
K
Q
A
L
E
T
V
Q
R
L
----------------------------
L
P
-------------------------------------
V
L
C
Q
A
H
G
L
T
P
D
Q
V
V
A
I
A
--
S
N
G
G
G
K
Q
A
L
E
T
V
--
Q
R
L
L
P
G
--------
L
T
-
Q
E
-------------
Q
V
V
A
I
A
S
N
N
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
G
L
T
P
-----------------------
D
Q
V
V
A
I
A
S
N
---
G
G
G
K
Q
A
L
E
T
-
V
Q
R
L
L
P
V
------
L
C
Q
A
H
G
L
T
P
A
Q
V
V
A
I
A
S
N
-----------------------------------
I
-
G
G
K
Q
A
L
E
T
V
Q
R
L
L
---
P
V
-------------------------------
L
C
---
Q
D
H
G
L
T
L
A
Q
V
V
A
I
A
S
-
N
---------
I
------
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
G
L
T
Q
D
Q
V
V
A
I
A
S
N
I
-
G
G
K
Q
A
L
-
E
T
--
V
Q
R
L
L
P
V
L
C
Q
D
H
G
L
----------------------
T
P
D
Q
V
V
A
I
A
S
N
I
G
G
K
---------
Q
A
L
E
T
V
Q
-
R
L
L
P
V
L
C
Q
D
H
G
L
T
L
D
Q
V
V
A
I
A
S
------------------------------------------------------------
N
G
G
K
Q
A
L
E
T
V
-----
Q
------------
R
L
L
P
V
L
C
Q
D
H
G
L
T
P
D
------------
Q
V
V
A
I
A
S
N
S
G
-
22
HHSearch
42.44
24%
3
- C3 -
-
3PDT
1
A:
[22-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
M
G
I
L
W
E
---
F
D
P
I
I
N
K
W
I
R
L
S
M
K
L
K
V
E
--------
R
K
P
F
A
E
-
G
A
L
R
E
A
Y
H
T
V
S
L
G
---
V
G
T
DENYPLGTTKLFPPIEMISPISKNN
E
A
M
T
Q
L
K
---
N
G
T
K
F
V
L
K
L
Y
K
K
E
--Q
Q
---------
A
S
R
E
L
-
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
---
P
K
K
I
E
F
L
M
S
W
V
V
E
L
-
I
D
--
R
S
P
-------------------------
S
S
-----
N
G
Q
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
T
----------------
N
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
---
D
P
Q
I
H
---
T
P
D
G
-----
K
--
G
F
G
-----
L
G
N
L
G
K
A
G
I
N
K
F
-----
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
----------------------------------
26
HHSearch
41.61
20%
4
- C3 -
-
3PDT
1
A:
[22-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
--
M
G
----
I
L
W
E
F
D
P
I
I
N
K
W
I
R
L
--------
S
M
K
L
K
V
E
R
--
K
P
---
F
A
E
----------------
G
A
L
R
E
A
Y
----
H
T
V
S
----
L
G
V
G
T
DENYPLGTTKLFPPIEMISPISKNN
E
A
M
T
Q
L
K
N
G
T
K
F
V
L
K
L
Y
K
K
E
--Q
Q
---------
A
S
R
E
L
------------------------
Y
F
E
D
V
---
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
---------
K
K
I
E
F
L
M
S
---
W
V
V
-
E
L
I
D
R
---
S
--------------------------
P
S
S
--
N
-----
G
Q
P
I
L
C
S
I
E
P
L
L
------
V
G
E
F
K
K
N
N
S
-----
N
----
Y
G
---
A
V
L
T
--------------
N
R
S
T
P
-------
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
D
----------------
P
Q
I
H
---
T
P
D
G
-----
K
--
G
F
G
L
G
N
L
-------
G
K
A
G
----
I
N
K
F
I
T
T
-----
H
K
C
N
-
A
V
C
A
L
L
D
L
---
D
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
40.94
38%
-384
- C3 -
-
1ZW2
-
B:
[1-21]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
A
A
--
K
S
I
A
A
A
--------
T
S
A
L
V
-------------
K
A
A
S
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
40.87
24%
25
- C3 -
-
1IAH
2
B:
[38-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
S
S
P
S
I
---
L
N
N
S
M
S
S
W
S
Q
L
G
L
C
A
K
I
E
F
L
------
S
K
E
E
M
G
-
G
G
L
R
R
A
V
K
V
L
C
T
W
---
S
E
-------------------------------
H
D
ILK
S
G
H
L
Y
I
I
K
S
F
L
P
E
V
I
-
N
T
W
S
SIYKED
T
V
L
H
L
-
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
K
S
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
-
H
---------------------------------------
S
A
G
Q
W
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
I
I
P
------------
T
N
T
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
----
N
L
T
---
D
P
S
V
I
---
K
A
E
E
KRSCD
M
--
V
F
G
-----
P
A
N
L
G
E
D
A
I
K
N
F
-----
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
------------------------------
21
HHSearch
40.19
23%
13
- C3 -
-
3LKM
1
A:
[22-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
M
G
I
L
W
E
---
F
D
P
I
I
N
K
W
I
R
L
S
M
K
L
K
V
E
--------
R
K
P
F
A
E
-
G
A
L
R
E
A
Y
H
T
V
S
L
G
---
V
G
T
DENYPLGKLFPPIEMISPISKNN
E
A
M
T
Q
--
L
K
---
N
G
T
K
F
V
L
K
L
Y
K
K
E
--Q
Q
---------
A
S
R
E
L
-
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
---
P
K
K
I
E
F
L
M
S
W
V
V
E
L
-
I
D
--
R
S
P
-------------------------
S
S
-----
N
G
Q
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
T
----------------
N
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
---
D
P
Q
I
H
---
T
P
D
G
-----
K
--
G
F
G
-----
L
G
N
L
G
K
A
G
I
N
K
F
-----
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
----------------------------------
25
HHSearch
39.91
24%
36
- C3 -
-
1IA9
1
TRPM7_MOUSE
A:
[38-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
S
S
P
S
I
---
L
N
N
S
M
S
S
W
S
Q
L
G
L
C
A
K
I
E
F
L
------
S
K
--
M
G
-
G
G
L
R
R
A
V
K
V
L
C
T
W
---
S
E
-------------------------------
H
D
ILK
S
G
H
L
Y
I
I
K
S
F
L
P
E
V
I
-
N
T
W
S
SIYKED
T
V
L
H
L
-
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
K
S
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
-
H
---------------------------------------
S
A
G
Q
W
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
I
I
P
------------
T
N
T
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
----
N
L
T
---
D
P
S
V
I
---
K
A
E
E
KRSCD
M
--
V
F
G
-----
P
A
N
L
G
E
D
A
I
K
N
F
-----
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
------------------------------
23
HHSearch
39.37
19%
-4
- C3 -
-
3LKM
1
A:
[22-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
--
M
G
----
I
L
W
E
F
D
P
I
I
N
K
W
I
R
L
--------
S
M
K
L
K
V
E
R
--
K
P
---
F
A
E
----------------
G
A
L
R
E
A
Y
----
H
T
V
S
----
L
G
V
G
T
DENYPLGKLFPPIEMISPISKNN
E
A
M
T
Q
--
L
K
N
G
T
K
F
V
L
K
L
Y
K
K
E
--Q
Q
---------
A
S
R
E
L
------------------------
Y
F
E
D
V
---
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
---------
K
K
I
E
F
L
M
S
---
W
V
V
-
E
L
I
D
R
---
S
--
P
------------------------
S
S
--
N
-----
G
Q
P
I
L
C
S
I
E
P
L
L
------
V
G
E
F
K
K
N
N
S
-----
N
----
Y
G
---
A
V
L
T
--------------
N
R
S
T
P
-------
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
D
----------------
P
Q
I
H
---
T
P
D
G
-----
K
--
G
F
G
L
G
N
L
-------
G
K
A
G
----
I
N
K
F
I
T
T
-----
H
K
C
N
-
A
V
C
A
L
L
D
L
---
D
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
38.46
23%
-35
- C3 -
-
4KUJ
-
?
B:
[40-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
---
S
N
Q
R
I
N
Q
F
L
F
Q
H
S
T
F
R
V
E
--------
L
A
P
F
A
K
-
G
G
E
R
L
A
F
R
A
I
N
G
R
------------------------------------------
G
D
R
I
V
L
K
R
F
F
Q
Q
R
-------------
P
L
T
M
-
L
L
E
T
I
E
R
Q
L
I
C
I
Y
L
A
N
I
F
N
K
L
N
V
S
--
P
N
K
L
H
F
L
P
N
Y
L
F
I
P
-
S
P
--
T
K
------
D
L
D
G
K
I
L
----------
T
L
E
Q
T
E
Q
A
V
A
A
T
C
R
T
P
N
F
V
E
P
Y
L
S
G
Y
F
I
K
Y
I
D
N
N
G
W
I
N
E
--------------
S
E
F
H
S
T
L
H
A
F
A
H
W
T
W
V
H
T
K
G
A
L
L
I
C
D
I
Q
G
V
N
A
NNKF
Y
L
T
---
D
P
A
L
H
---
H
I
D
Q
-----
N
KF
I
Y
S
-----
E
T
N
L
G
E
V
G
I
S
Q
F
-----
F
R
T
H
Q
C
N
A
I
C
Q
G
L
H
L
P
K
H
K
E
Q
V
L
P
D
--------------------------
32
Fugue
38.06
21%
27
- C3 -
-
1IA9
2
TRPM7_MOUSE
A:
[3-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
Y
S
A
V
E
R
---
N
N
L
M
R
L
S
Q
S
-
I
P
F
V
P
V
P
------
P
-
R
G
E
P
V
T
V
Y
R
L
E
E
S
S
P
S
I
---
L
N
N
S
M
S
S
W
S
Q
L
G
L
C
A
K
I
E
F
L
------
S
--
K
M
G
-
G
G
L
R
R
A
V
K
V
L
C
T
W
SEH
D
I
-------------------------------
L
K
---
S
G
H
L
Y
I
I
K
S
F
L
P
E
V
I
-
N
T
W
S
SIYKED
T
V
L
H
L
-
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
K
S
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
-
H
---------------------------------------
S
A
G
Q
W
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
I
I
P
T
------------
N
T
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
----
N
L
T
---
D
P
S
V
I
---
K
A
E
E
-----
K
--
R
S
C
DMVF
G
P
A
N
L
G
E
D
A
I
K
N
F
-----
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
D
Y
T
---------------------------
35
Fugue
35.02
15%
-16
- C3 -
-
4XHJ
7
GH_VZVO
A:
[36-791]
---------------------------------------------------------------
A
L
L
R
E
Y
S
D
-------
R
N
M
S
L
K
L
E
A
----
F
Y
-----------
P
T
G
F
D
E
E
L
I
K
S
L
H
W
G
N
D
R
K
H
V
F
L
V
I
V
K
V
N
P
T
T
H
E
G
D
V
G
L
V
I
F
P
K
Y
L
L
S
----
P
Y
--
R
F
-
G
F
L
S
H
P
------
V
T
--
P
D
V
S
F
F
D
S
--
S
F
----
A
P
Y
L
T
T
Q
H
L
V
A
F
T
T
F
--------
P
P
N
P
L
V
W
H
L
E
R
A
ETA
A
T
A
----------------
E
R
P
F
G
V
S
----
L
L
P
A
----
R
P
T
--------------------------------
V
P
K
N
T
I
L
E
H
K
A
H
F
A
T
W
D
-
A
---------
L
A
R
H
T
------------------------
F
F
S
------
A
E
A
I
I
T
N
S
T
L
R
I
H
V
P
L
F
G
S
V
W
P
I
R
Y
W
A
T
G
S
V
L
L
T
S
DS
G
R
V
E
V
N
I
G
V
----------------
G
F
----------
M
S
S
L
I
S
L
S
S
-----
G
L
P
I
E
L
I
V
V
P
H
T
V
K
L
N
A
V
T
S
D
T
T
W
F
Q
L
N
P
P
GP
D
----
P
G
PS
Y
R
V
Y
L
L
G
RGL
D
-
M
N
F
S
K
H
A
T
V
D
I
C
A
YPEESL
D
Y
R
Y
H
L
S
M
A
H
T
E
A
L
R
M
T
T
K
-
A
D
Q
H
D
----
I
N
E
E
----------------
S
Y
Y
H
I
A
A
R
I
A
T
-----
S
--
I
F
A
L
S
E
M
-------
G
R
T
T
EYFL
L
D
E
I
V
D
V
-----
Q
Y
Q
L
-
K
F
L
N
Y
I
L
M
R
IG
A
G
A
H
P
N
T
I
S
G
T
S
D
L
I
F
A
D
P
S
Q
L
H
D
E
L
S
L
L
F
G
Q
F
I
S
Y
D
E
A
R
D
Q
L
K
T
A
Y
A
L
S
R
G
Q
-----------
D
H
V
N
A
L
S
L
----
A
R
R
V
I
M
----
S
I
Y
K
G
L
L
V
K
Q
N
L
N
A
T
E
R
Q
A
L
F
F
A
S
M
I
L
-
L
N
F
S
S
R
V
L
D
G
R
T
T
---
L
L
L
M
T
S
M
-
C
T
A
A
H
A
T
Q
A
A
-------
L
N
I
Q
E
G
---
L
A
Y
L
N
P
----------------
S
K
H
M
F
T
I
P
N
V
Y
S
----
P
C
M
G
---
S
L
R
T
D
L
T
E
E
I
H
V
M
N
L
L
S
A
I
P
T
-----------
R
P
G
L
N
E
V
L
H
T
Q
L
D
E
S
E
I
F
D
A
-----
A
F
K
T
M
M
I
F
------------------
T
T
----
W
T
A
K
D
L
H
I
L
H
T
---------
H
V
P
E
V
F
T
C
Q
D
A
A
A
R
N
--
G
E
Y
V
L
I
----
L
P
A
V
------
Q
G
H
S
Y
V
I
T
R
N
K
P
Q
R
G
---
L
V
Y
S
L
A
D
V
D
V
Y
N
P
I
S
V
V
Y
L
S
-----------
K
D
T
C
V
S
E
H
G
V
I
E
T
V
--------------
A
L
P
------------
H
P
D
N
L
K
E
CL
Y
C
G
S
V
F
L
R
------
Y
L
--------
T
T
G
A
I
M
D
I
I
I
I
D
S
K
D
T
E
R
Q
L
A
A
M
GN
S
T
I
P
P
F
--------
N
P
D
M
H
-------------
G
D
D
S
K
A
V
L
L
F
P
N
G
T
V
V
T
L
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
33.34
16%
-45
- C3 -
-
4KUJ
-
?
B:
[40-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
S
N
Q
R
I
N
Q
F
L
F
Q
--------
H
S
T
F
R
V
E
L
--
A
P
---
F
A
K
----------------
G
G
E
R
L
A
F
----
R
A
I
N
----
G
------------------------------------
R
G
D
R
I
V
L
K
R
F
F
Q
Q
-------------
R
P
L
T
M
------------------------
L
L
E
T
I
---
E
R
Q
L
I
C
I
Y
L
A
N
I
F
N
K
L
N
V
S
P
--------
N
K
L
H
F
L
P
N
---
Y
L
F
-----------
I
P
S
P
T
K
D
L
D
G
K
I
----------
L
T
L
E
Q
T
--
E
Q
A
V
A
A
T
C
R
T
P
N
F
V
E
P
Y
L
------
S
G
Y
F
I
K
Y
I
D
-----
N
----
N
G
---
W
I
N
--
E
----------
S
E
F
H
S
T
L
-------
H
A
F
A
H
W
T
W
V
H
T
K
G
A
L
L
I
C
D
I
Q
G
V
N
A
NNKF
Y
L
T
D
----------------
P
A
L
H
---
H
I
D
Q
-----
N
KF
I
Y
S
E
T
N
L
-------
G
E
V
G
----
I
S
Q
F
F
R
T
-----
H
Q
C
N
-
A
I
C
Q
G
L
H
L
---
P
K
H
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
33.30
28%
33
- C3 -
-
5E9E
1
MHCKA_DICDI
A:
[109-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
L
Y
K
K
E
---
Q
---------
Q
A
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
---
P
K
K
I
E
F
L
M
S
W
V
V
E
L
I
D
R
--
S
P
--------------------------
S
S
-----
N
G
Q
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
-
A
V
L
T
N
--
R
S
T
P
-------------
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
---
D
P
Q
I
H
---
T
P
D
G
-----
K
--
G
F
G
-----
L
G
N
L
G
K
A
G
I
N
K
F
-----
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
------------------------------------
5
PsiBlast_PDB
32.75
28%
32
- C3 -
-
3PDT
1
A:
[109-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
L
Y
K
K
E
---
Q
---------
Q
A
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
---
P
K
K
I
E
F
L
M
S
W
V
V
E
L
I
D
R
--
S
P
--------------------------
S
S
-----
N
G
Q
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
-
A
V
L
T
N
--
R
S
T
P
-------------
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
---
D
P
Q
I
H
---
T
P
D
G
-----
K
--
G
F
G
-----
L
G
N
L
G
K
A
G
I
N
K
F
-----
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
------------------------------------
3
PsiBlast_PDB
32.70
28%
28
- C3 -
-
3LLA
1
MHCKA_DICDI
A:
[109-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
L
Y
K
K
E
---
Q
---------
Q
A
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
---
P
K
K
I
E
F
L
M
S
W
V
V
E
L
I
D
R
--
S
P
--------------------------
S
S
-----
N
G
Q
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
-
A
V
L
T
N
--
R
S
T
P
-------------
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
---
D
P
Q
I
H
---
T
P
D
G
-----
K
--
G
F
G
-----
L
G
N
L
G
K
A
G
I
N
K
F
-----
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
------------------------------------
2
PsiBlast_PDB
32.56
28%
31
- C3 -
-
3LKM
1
A:
[109-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
L
Y
K
K
E
---
Q
---------
Q
A
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
---
P
K
K
I
E
F
L
M
S
W
V
V
E
L
I
D
R
--
S
P
--------------------------
S
S
-----
N
G
Q
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
-
A
V
L
T
N
--
R
S
T
P
-------------
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
---
D
P
Q
I
H
---
T
P
D
G
-----
K
--
G
F
G
-----
L
G
N
L
G
K
A
G
I
N
K
F
-----
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
------------------------------------
7
PsiBlast_PDB
32.40
27%
25
- C3 -
-
4ZMF
1
MHCKA_DICDI
A:
[109-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
L
Y
K
K
E
A
--------------
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
---
P
K
K
I
E
F
L
M
S
W
V
V
E
L
I
D
R
--
S
P
--------------------------
S
S
-----
N
G
Q
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
-
A
V
L
T
N
--
R
S
T
P
-------------
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
----
P
Q
I
H
---
T
P
D
G
-----
K
--
G
F
G
-----
L
G
N
L
G
K
A
G
I
N
K
F
-----
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
------------------------------------
27
HHSearch
32.27
15%
-12
- C3 -
-
1IAH
2
B:
[27-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
G
E
P
V
T
V
--
Y
R
LEES
S
P
S
I
L
N
N
S
M
S
S
W
S
Q
L
--------
G
L
C
A
K
I
E
F
L
S
K
E
---
E
M
G
----------------
G
G
L
R
R
A
V
----
K
V
L
C
TWSE
H
D
I
--------------------------------
L
K
S
G
H
L
Y
I
I
K
S
F
L
P
E
V
I
-
N
T
W
S
SIYKED
T
V
L
H
L
------------------------
C
L
R
E
I
---
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
K
-----
S
I
P
-
Y
S
P
R
F
L
E
V
---
F
L
L
-
Y
----------------------------------
C
----
H
-----
S
A
G
Q
W
F
A
V
E
E
C
M
------
T
G
E
F
R
K
Y
N
N
-----
N
----
N
G
---
D
E
I
I
P
T
---
N
-------
T
L
E
E
I
M
-------
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
----
N
L
T
D
----------------
P
S
V
I
---
K
A
E
E
KRSCD
M
--
V
F
G
P
A
N
L
-------
G
E
D
A
----
I
K
N
F
R
A
K
-----
H
H
C
N
-
S
C
C
R
K
L
K
L
---
P
D
L
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
32.18
19%
11
- C3 -
-
3LKM
1
A:
[22-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
M
G
I
L
W
E
---
F
D
P
I
I
N
K
W
I
R
L
S
M
K
L
K
V
--
E
------
R
K
P
F
A
E
-
G
A
L
R
E
A
Y
H
T
V
S
L
G
---
V
G
-------------------------------
T
D
---
E
N
Y
P
L
G
K
L
F
P
P
I
E
M
I
-
S
---------
P
I
S
K
N
-
N
E
A
M
T
Q
L
K
N
G
T
K
F
V
L
K
L
Y
K
K
E
Q
Q
A
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
-
D
W
--
G
N
K
F
N
Q
K
K
P
P
K
K
I
E
F
L
M
S
W
V
V
E
LID
R
S
P
S
S
-----
N
G
Q
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
T
N
R
----------------
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
---
D
P
Q
I
H
---
T
P
D
G
-----
K
--
G
F
G
-----
L
G
N
L
G
K
A
G
I
N
K
F
-----
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
----------------------------------