@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LINJ_22_0370: (2018-07-13 )
MGACVCVHVFRLLLCSRFFLFAVPSSSPAPPSRVSCPSSQKAFLRARVCVPRRASRCGSGSSRHRAPVARIRTFTRIAHSPKALSKYCPFTPLSTSSCFSRFAFFRPPFPLPTLQVMSEKSVRSRRPLSVSRASARASAASRPQLHRTVSSDGASPSQATAPMYRPLRYVGRGSFGVVLLAEEVHTGVKVAIKRVHYDARLHNREVAILNSVLVDNPRHQQPSHTVVDSNDASRLPGGAARASSTSFLSASSSSHTVEDVHLWPGTHHPNIVELLDFYVTYDTASSEQALGPDMVGVGGASAGFESLPSHHPAAHRYPLSGGSGAASTNAPPVSAPLAAFAYLEMVMSYLPMDLCYVKKYYFRFHDMPTMVTSSSPSPLASPEQAAAELLSGELPEGTADRPPASPKHAGTGCNGSNSSRHSSTGGSGGDAFNHLPLRWVKVVLFQLARALAFMHVRHVCHRDLKPANVLVDPDTGRVQVCDFGSAKQIARPAEEKNVSYICSRYYRAPELLFGALHYGCAVDMWSFGCIAAELLRESGKPLFRGCTSIDQMAELFKVLGAPSKREMYAMNPQCAEALLRTRAMHRHQSLDTDPHSGSGGGVRQDRSCGLELEVDYQAEEEDDVELRGGAQQGGYDVDGHGDFLRDALDDGISSQASASPGMATASPPSSCTKDPRDYKTAFSAPPSTAATATLDDVAPTPFEEYYDVLKVHAIPWRRLFPADTPTEAVALVASLLCYAPDKRLTAAELVEHPFFDDLFSAADAQLGAVGRDTATAMASGTTNSPSEDDGVASAALRLPNGRLMPLSMFQVTEVERGLYTDAFLTRMARQAELVAAAMKQDEYP
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200-.........210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450...--....460.......470...-..--..480.......490..--.---....500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MG
A
C
V
C
V
H
V
F
R
L
L
L
C
S
R
F
F
L
F
AVPSSSPAPPSRVSCPS
S
Q
K
A
F
L
R
A
RVCV
P
R
R
A
S
RCGSGSSRHR
A
P
V
A
R
I
R
T
F
T
R
IAHS
P
K
A
L
S
KYCPFTPL
S
T
S
S
C
F
S
R
F
AFFRPPFPL
P
T
L
Q
V
M
S
E
KSVRSRRPLSV
S
R
ASARASAASRPQ
L
H
R
TVSSDGASPSQATA
P
M
Y
R
P
L
R
Y
VGRGS
F
G
V
V
L
L
A
E
E
VHT
G
V
K
V
A
I
K
R
V
H
Y
D
A
R---LHN
R
E
V
A
I
L
N
S
V
LVDNPRHQQPS
H
T
V
VDSNDASRLPGGAARASS
T
S
F
L
SASSSS
H
T
V
E
D
V
H
LWPGTHHP
N
I
V
E
L
L
D
F
Y
VTYDTASSEQALGPDMVGVGGA
S
A
G
F
E
SLPSHHPAAHRYPLSGGSGAASTNAPPVS
A
P
L
A
A
F
A
Y
L
E
M
V
M
S
YL
P
M
D
L
C
Y
V
K
K
Y
Y
F
R
FHDMPTMVTSSSPSPLA
S
P
E
Q
A
A
A
E
L
LSGELPEGTADRPPASPKHAGTGCNGSNSSRHSSTGGSGGDAFNHL
P
L
R
W
V
K
V
V
L
F
Q
L
A
R
A
L
A
F
M
H
--
V
R
H
V
C
H
RDLKPA
N
V
L
VDPDT-G
R
--
V
Q
V
CDFG
S
A
K
Q
IARP
A
E
--E---K
N
V
S
Y
I
C
S
R
Y
YR
A
P
E
L
L
F
G
A
L
H
YGCA
V
D
M
W
S
F
G
C
I
A
A
E
L
L
R
ESG
K
P
L
F
R
G
CT
S
I
D
Q
M
A
E
L
F
K
V
LGAPSKR
E
M
Y
AM
N
P
Q
C
A
E
A
L
L
R
T
R
A
M
H
RHQSLDTDPHSGSGGGVRQDRSCG
L
E
L
E
V
D
YQAEEEDD
V
E
LRGGAQQGGYDVDG
H
G
D
F
L
R
D
A
L
DDGISSQASASPGMATASP
P
S
SCTKDPRDYKTAFSAPPSTAA
T
A
TLDDVAPT
P
F
E
E
Y
Y
D
V
L
K
V
HAI
P
W
R
RLFPADT
P
T
E
A
V
A
L
V
A
S
L
L
CYAPDKRL
T
A
A
E
L
V
EHP
F
F
D
D
L
F
S
A
A
D
A
QLGAVGRD
T
A
T
AMASGTTNSPSEDD
G
V
A
S
A
A
LRLPNG
R
L
M
P
L
S
M
F
Q
V
T
E
V
ERGL
Y
T
D
A
F
L
T
R
M
A
R
Q
A
E
L
V
A
A
A
M
KQDEYP
22
HHSearch
85.52
45%
-124
- C1 -
-
4NM5
4
GSK3B_HUMAN
A:
[32-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
R
---
F
K
N
R
E
------------------------------------------------------
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
-----------------------------------------------------
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
-------------------------------------------------------------------
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
----
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
83.24
45%
-122
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[44-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
R
---
F
K
N
R
E
------------------------------------------------------
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
-----------------------------------------------------
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
-------------------------------------------------------------------
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
----
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
82.89
45%
-118
* C1 *
-
3SD0
2
GSK3B_HUMAN
A:
[8-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
R
---
F
K
N
R
------------------------------------------------------
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
-----------------------------------------------------
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
-------------------------------------------------------------------
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
----
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
81.52
45%
-127
- C1 -
-
5K5N
1
GSK3B_HUMAN
A:
[28-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------
A
T
P
G
---
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
--------
N
R
------------------------------------------------------
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
---------------------------------------------------------
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
-------------------------------------------------------------------
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
----
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
81.02
37%
-148
- C1 -
-
3EB0
2
?
A:
[6-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
K
Y
S
L
G
K
T
L
G
T
G
-
F
G
I
V
C
E
V
F
D
I
E
S
G
K
R
F
A
L
K
K
V
L
Q
D
P
R
---
Y
K
N
R
------------------------------------------------------
E
L
D
I
M
K
V
L
D
H
V
N
I
I
K
L
V
D
Y
F
Y
T
T
----------------------------------------------------------
N
K
Y
L
N
V
I
M
E
Y
V
P
D
T
L
H
K
V
L
K
S
F
I
R
S
-------------------------------------------------------------------
G
R
S
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
--
S
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
N
S
K
D
-
N
T
--
L
K
L
C
D
F
G
S
A
K
K
L
I
P
S
----
E
---
P
S
V
A
Y
I
C
S
R
F
Y
R
A
P
E
L
M
L
G
A
T
E
Y
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
L
--
G
K
P
L
F
S
G
E
T
S
I
D
Q
L
V
R
I
I
Q
I
M
G
T
P
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
70.26
32%
-105
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[4-237]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
---
V
V
------------------------------------------------
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
Y
G
-----------------------------------------------------
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
-----------------------------------------------------------------------
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
--
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
--
C
E
--
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
--
E
HQY
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
--
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
69.69
45%
-78
- C- -
-
3E3P
-
?
A:
[13-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
K
E
M
D
R
F
Q
V
E
----------
V
Q
L
G
K
E
K
S
T
G
M
S
V
A
I
K
K
V
I
Q
D
P
R
---
F
R
N
R
---------------------------------------------------
E
L
Q
I
M
Q
D
L
A
V
L
H
H
P
N
I
V
Q
L
Q
S
Y
F
Y
T
L
G
E
R
D
----------------------------------------------------
R
R
D
I
Y
L
N
V
V
M
E
Y
V
P
D
T
L
H
R
C
C
R
N
Y
Y
R
R
-------------------------------------------------------------------
Q
V
A
P
P
P
I
L
I
K
V
F
L
F
Q
L
I
R
S
I
G
C
L
H
LP
S
V
N
V
C
H
R
D
I
K
P
H
N
V
L
V
N
E
A
D
-
G
T
--
L
K
L
C
D
F
G
S
A
K
K
L
S
P
S
----
E
---
P
N
V
A
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
N
Q
H
Y
T
T
A
V
D
I
W
S
V
G
C
I
F
A
E
M
M
L
--
G
E
P
I
F
R
G
D
N
S
A
G
Q
L
H
E
I
V
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.20
53%
-133
- C1 -
-
1R0E
-
GSK3B_HUMAN
A:
[124-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
67.55
53%
-142
- C1 -
-
3I4B
1
GSK3B_HUMAN
A:
[147-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
67.54
32%
0
- C- -
-
5CI6
-
MPK6_ARATH
B:
[32-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
T
A
K
Y
K
P
P
I
M
P
I
G
K
G
A
Y
G
I
V
C
S
A
M
N
S
E
T
N
E
S
V
A
I
K
K
I
A
N
A
F
D
---
N
------------------------------------------------
K
I
D
A
K
R
T
L
R
E
I
K
L
L
R
H
M
D
H
E
N
I
V
A
I
R
D
I
I
P
P
P
L
R
N
------------------------------------------------------
A
F
N
D
V
Y
I
A
Y
E
L
M
D
T
D
L
H
Q
I
I
R
S
N
-----------------------------------------------------------------------
Q
A
L
S
E
E
H
C
Q
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
--
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
A
N
--
C
D
--
L
K
I
C
D
F
G
L
A
R
V
T
-----------------
V
T
R
W
Y
R
A
P
E
L
L
L
N
S
S
D
Y
T
A
A
I
D
V
W
S
V
G
C
I
F
M
E
L
M
D
--
R
K
P
L
F
P
G
R
D
H
V
H
Q
L
R
L
L
M
E
L
I
G
T
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
67.25
31%
-109
- C1 -
-
4ZZN
1
MK01_HUMAN
A:
[11-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
N
K
V
R
V
A
I
K
K
I
S
P
F
E
H
---
Q
-------------------------------------------------
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
------------------------------------------------------
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
------------------------------------------------------------------------
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
--
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
--
C
D
--
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
H
D
H
T
G
---
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
--
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
67.23
53%
-139
- C1 -
-
4ACD
1
GSK3B_HUMAN
A:
[198-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
66.98
53%
-139
- C1 -
-
1J1B
1
GSK3B_HUMAN
A:
[153-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
66.96
53%
-139
- C1 -
-
1J1C
1
GSK3B_HUMAN
A:
[153-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
66.94
53%
-136
- C1 -
-
4ACH
1
GSK3B_HUMAN
A:
[198-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
66.72
53%
-134
- C1 -
-
4PTE
1
GSK3B_HUMAN
A:
[174-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
66.70
53%
-138
- C1 -
-
4ACC
2
GSK3B_HUMAN
A:
[198-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
66.30
53%
-133
- C1 -
-
4ACG
1
GSK3B_HUMAN
A:
[198-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
66.17
53%
-131
- C1 -
-
4NM0
3
GSK3B_HUMAN
A:
[153-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
66.10
53%
-138
- C1 -
-
1UV5
1
GSK3B_HUMAN
A:
[119-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
66.05
53%
-142
- C1 -
-
4PTC
1
GSK3B_HUMAN
A:
[174-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
65.38
53%
-147
- C1 -
-
2O5K
1
GSK3B_HUMAN
A:
[132-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
65.35
53%
-135
- C1 -
-
4NM3
2
GSK3B_HUMAN
A:
[153-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
--
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
65.34
53%
-129
- C1 -
-
4NM7
3
GSK3B_HUMAN
A:
[141-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
64.55
53%
-130
- C1 -
-
4NM5
3
GSK3B_HUMAN
A:
[141-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
64.48
53%
-140
- C1 -
-
1H8F
2
GSK3B_HUMAN
A:
[119-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
--
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
64.18
53%
-132
- C1 -
-
3SD0
2
GSK3B_HUMAN
A:
[119-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
--
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
63.97
53%
-131
- C1 -
-
4NU1
2
GSK3B_MOUSE
A:
[153-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-
A
V
--
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
--
E
---
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
--
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
62.08
35%
-52
- C1 -
-
5LXC
8
DYRK2_HUMAN
A:
[71-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
------------------------------------------------
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
-----------------------------------------------------------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
---------------------------------------------------------------------
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
--
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
---------
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
--
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
60.01
35%
-50
- C1 -
-
4AZF
1
DYRK2_HUMAN
A:
[94-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
------------------------------------------------
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
-----------------------------------------------------------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
---------------------------------------------------------------------
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
G
--
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
---------
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
--
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------