@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LINJ_27_2420: (2018-07-13 )
MGRSMGLTAEAIAPSEGHFRHHYSLGDEIGKGAYAVVFRCNHRETKAVYAVKIVDKRKAGPKDIDDITHEIDVMGRIGYHPNVVQMIEYFSTERRFYIILDLLSGGMLFDRIIELKHYSESNASVLVRNVLSGLAHIHSRGVIHRDLKPENLLLRYAASPSTSPNSNLTDVCLADFGLAGYVPSTTCCGSPSYIAPEVISVGYYRTRKEPYDAKCDIWSIGVITYILLSGKMPFHGNSFKETFELIVSNRWSFNSDTWASVTPTAKDFIQACLTYDPVERPTALELLQHPWLANEQPHVHLGRSLESLRDLTKKKVKAAVQVFCWTQSLLGPLDWTPPFMRFLRHTDKFSTVLTHQSQTDPKQVHTVDFSKALDHKKPGWRIQDCCTCPSEQVCRHIQNVHEYLFVGKRSMEVYPFIDELRMMHEEAEDSLTADPRDAEARKRLDQVNYLIEAACVFSDELAKVPAGELKPNLMLDGSRNTLFRALGGSRSVTKTWHGSDKEDVAHRVVEKMRAQKLASPATGKTTKAAAMPPSSTPTPKPSSKPSSSKRITTTPNAGTPSRRS
Atome Classification :
(28 SA)
.........10........20........30........40........50........60-----.----........70........80........90........100.......110....----...120.......130.......140.......150.......160.......170.......180..-----.-----.-----.----..190.......200.......210.......220.......230...---....240.......250.......260.......270.......280.......290----....---.---.------.--300---.......----..310-.......320.......330...-.....340.......350.......360.......370------------.........-380........390.......400.......410.......420--........430.-......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGRSMGL
T
A
E
AIAPSEGH
F
R
H
HYSLGDEIGK
G
A
Y
A
V
V
F
R
CNHRE
T
K
A
V
Y
A
V
K
I
V
DKRKAG------P----K
D
I
D
D
I
T
H
E
I
D
V
MGRIGYHP
N
V
V
Q
M
I
E
Y
FSTE
R
R
F
Y
I
I
L
D
L
LSG
G
M
L
F
D
R
I
I
E
L
K----HYSES
N
A
S
V
L
V
R
N
V
L
S
G
L
A
H
I
H
SRGVIHRDLKPE
N
L
L
L
R
YAASPSTSPNSN
L
T
D
V
C
L
A
D
FGLAGYVPS-----T-----T-----C----CGSPSYI
A
P
E
V
I
S
VG
Y
Y
RTRKEPYDAKC
D
I
W
S
I
G
V
I
T
Y
I
L
LSGKMPFH---GN
S
F
K
E
T
F
E
L
I
V
SNRWSFNSDTWASVTP
T
A
K
D
F
I
Q
A
C
LTYDPVER
P
T
A
L
E
L
L
QHPWL----ANEQ---P---
H
------
V
--
H
-----
L
G
R
S
L
E
S
----
L
R
D
L
T
-
K
K
K
V
K
A
A
V
Q
V
F
C
W
T
Q
S
LL-GPLD-W
T
P
P
F
M
R
F
L
R
H
T
D
K
F
S
T
V
L
THQSQTDPK
Q
V
H
T
V
D
F
S
--------------
K
ALDHKKPG-
W
R
-
I
Q
D
CCTC
P
S
E
Q
V
C
R
H
I
Q
N
V
H
E
Y
L
F
VGKRSMEVY
P
F
I
D
E
L
R
---
M
M
H
E
EAEDSLTA-DPR
D
A
E
A
R
K
R
L
D
Q
V
N
Y
L
I
E
A
A
C
V
F
S
D
E
L
A
KVPAGELKP
N
L
M
L
DGSR
N
T
L
F
R
ALGGSRS
V
T
KTWHGS
D
K
E
D
V
A
H
R
V
V
E
K
M
R
A
Q
KLASPATGKTTKAAAMPPSSTPTPKPSSKPSSS
K
R
I
TTTPNAGTPSRRS
3
PsiBlast_PDB
86.34
34%
-120
- C1 -
-
3NCG
1
?
A:
[17-378]
---------------
Q
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
------
N
----
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
--------
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
-----
N
-----
T
----------
I
G
T
A
Y
Y
I
A
P
E
V
L
--------
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
-
S
S
E
T
---
P
---
T
------
I
--
S
-----
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
-
A
E
K
-
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
-
T
T
L
D
-
E
T
K
Q
L
T
E
I
F
R
K
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
85.98
37%
-82
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[5-305]
---------------
S
T
K
F
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
A
K
--------
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
E
A
W
-
H
-----
G
-----
F
----
A
G
T
P
G
Y
L
S
P
E
V
L
K
-------
K
D
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
R
L
Y
A
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
T
A
D
Q
A
L
K
V
P
W
I
----
C
N
R
E
---
R
---
V
ASA---
I
--
H
-----
R
Q
D
T
V
D
C
----
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.26
34%
-117
- C1 -
-
3IGO
8
?
A:
[17-356]
---------------
Q
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
------
N
----
K
-
T
S
T
I
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
--------
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
-----
N
-----
T
------------
T
A
Y
Y
I
A
P
E
V
L
--------
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
-
S
S
E
T
---
P
---
T
------
I
--
S
-----
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
-
A
E
K
-
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
-
T
T
L
D
-
E
T
K
Q
L
T
E
I
F
R
K
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
84.22
34%
-82
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[5-303]
---------------
S
T
K
F
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
A
K
G
A
A
--------
V
K
L
A
D
F
G
L
A
I
E
V
N
D
-----
S
-----
E
-----
A
W
HGF
A
G
T
P
G
Y
L
S
P
E
V
L
-------
K
K
D
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
R
L
Y
A
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
T
A
D
Q
A
L
K
V
P
W
I
----
C
N
R
E
RVA
S
---
A
------
I
--
H
-----
R
Q
D
T
V
D
C
----
L
K
K
F
N
A
R
R
K
L
K
G
A
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
82.77
38%
-76
- C1 -
-
2VN9
1
KCC2D_HUMAN
B:
[2-297]
------------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
--------
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
DQQAW
F
-----
G
-----
F
----
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
Q
R
S
---
T
---
V
ASM---
M
--
H
-----
R
Q
E
T
V
D
C
----
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
81.83
36%
-79
- C1 -
-
2VZ6
2
KCC2A_HUMAN
A:
[19-310]
-----------------
Y
F
Q
S
M
Y
Q
L
F
E
E
L
G
K
--
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
H
Q
K
L
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
L
K
G
A
A
--------
V
K
L
A
D
F
G
L
A
I
E
V
E
G
-----
E
-----
Q
QAWFG
F
----
A
G
T
P
G
Y
L
S
P
E
V
L
-------
R
K
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
----
S
H
R
S
TVA
S
---
C
------
M
--
H
-----
R
Q
E
T
V
D
C
----
L
K
K
F
N
A
R
R
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
81.66
36%
-75
- C1 -
-
2V7O
3
KCC2G_HUMAN
A:
[29-321]
------------------
F
T
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
H
Q
K
L
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
A
A
--------
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
-----
E
-----
Q
QAWF
G
F
----
A
G
T
P
G
Y
L
S
P
E
V
L
-------
R
K
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
----
C
Q
R
S
TVA
S
---
M
------
M
--
H
-----
R
Q
E
T
V
E
C
----
L
R
K
F
N
A
R
R
K
L
K
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
81.62
38%
-97
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[2-301]
------------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
--------
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
DQQAW
F
-----
G
-----
F
----
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
Q
R
---------SM----
M
--
H
-----
R
Q
E
T
V
D
C
----
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
81.28
36%
-73
- C1 -
-
5U6Y
-
KCC2A_RAT
A:
[2-294]
----------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
H
Q
K
L
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
L
K
G
A
A
--------
V
K
L
A
D
F
G
L
A
I
E
V
E
G
-----
E
-----
Q
QAWFG
F
----
A
G
T
P
G
Y
L
S
P
E
V
L
-------
R
K
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
----
S
H
R
S
TVA
S
---
C
------
M
--
H
-----
R
Q
E
T
V
D
C
----
L
K
K
F
N
A
R
R
K
L
K
G
A
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
80.87
36%
-72
- C1 -
-
2VN9
2
KCC2D_HUMAN
A:
[6-296]
----------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
H
Q
K
L
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
--------
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
-----
D
-----
Q
QAWFG
F
----
A
G
T
P
G
Y
L
S
P
E
V
L
-------
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
Q
R
S
TVA
S
---
M
------
M
--
H
-----
R
Q
E
T
V
D
C
----
L
K
K
F
N
A
R
R
K
L
K
G
A
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.61
34%
-74
- C1 -
-
4Y5Q
1
?
A:
[17-361]
---------------
Q
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
------
N
----
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
--------
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
-----
N
-----
T
------DR--
I
G
T
A
Y
Y
I
A
P
E
V
L
--------
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
-
S
S
E
T
---
P
---
T
------
I
--
S
-----
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
-
A
E
K
-
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
-
T
T
L
D
-
E
T
K
Q
L
T
E
I
F
R
K
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
79.80
36%
-92
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[6-296]
----------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
H
Q
K
L
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
--------
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
-----
D
-----
Q
QAWFG
F
----
A
G
T
P
G
Y
L
S
P
E
V
L
-------
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
Q
R
----
S
---
M
------
M
--
H
-----
R
Q
E
T
V
D
C
----
L
K
K
F
N
A
R
R
K
L
K
G
A
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.23
34%
-79
- C1 -
-
3MWU
1
?
A:
[17-361]
---------------
Q
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
------
N
----
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
--------
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
-----
N
------------DR--
I
G
T
A
Y
Y
I
A
P
E
V
L
--------
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
-
S
S
E
T
---
P
---
T
------
I
--
S
-----
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
-
A
E
K
-
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
-
T
T
L
D
-
E
T
K
Q
L
T
E
I
F
R
K
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
79.12
30%
-86
- C1 -
-
3LIJ
1
?
A:
[28-360]
-----------
I
T
S
K
K
G
H
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
---------------
S
S
N
S
K
L
L
E
E
V
A
V
L
-
K
L
L
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
----
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
E
K
D
A
L
--------
I
K
I
V
D
F
G
L
S
A
V
F
E
N
-----
Q
-----
K
-----
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
--------
R
K
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
---
G
Q
T
D
Q
E
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
E
M
C
S
K
K
E
---
S
--------------L
P
S
--
L
A
N
A
I
E
N
----
M
R
K
F
Q
-
N
S
Q
-
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
-
T
S
Q
E
-
E
T
K
E
L
T
D
I
F
R
H
I
D
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
79.03
38%
-95
- C1 -
-
6AYW
2
KCC2D_HUMAN
A:
[11-275]
------------------
F
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
H
Q
K
L
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
--------
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
-----
D
-----
Q
QAWF
G
F
----
A
G
T
P
G
Y
L
S
P
E
V
L
-------
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
79.00
36%
-90
- C1 -
-
5FG8
3
KCC2A_DROME
A:
[12-277]
------------------
F
S
D
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
T
K
K
L
T
------
A
----
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
H
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
A
K
G
A
A
--------
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
-----
D
HQAWF
G
-----
F
----
A
G
T
P
G
Y
L
S
P
E
V
L
-------
K
K
E
P
Y
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
R
L
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
A
E
A
L
K
H
P
W
I
----
C
Q
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
78.92
36%
-85
- C1 -
-
5H9B
2
KCC2A_DROME
A:
[12-277]
------------------
F
S
D
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
T
K
K
L
T
------
A
----
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
H
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
A
K
G
A
A
--------
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
-----
D
HQAWF
G
-----
F
----
A
G
T
P
G
Y
L
S
P
E
V
L
-------
K
K
E
P
Y
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
R
L
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
A
E
A
L
K
H
P
W
I
----
C
Q
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
77.85
39%
-81
- C1 -
-
5IG1
-
?
A:
[15-303]
------------------
D
V
D
L
K
D
K
R
S
V
I
G
K
G
A
F
S
T
V
H
R
C
V
N
K
R
T
G
E
V
C
A
V
K
V
I
A
L
K
S
L
R
------
S
----
S
E
I
N
K
I
K
R
E
I
G
I
C
S
S
L
-
Q
H
E
H
I
V
S
M
R
R
A
F
R
D
E
S
H
F
Y
L
V
F
E
Y
V
S
G
G
E
L
F
D
E
I
V
T
R
K
----
F
Y
N
E
K
D
A
S
A
C
M
H
Q
I
L
S
A
L
Q
H
C
H
S
K
N
I
I
H
R
D
L
K
P
E
N
L
L
L
A
S
K
D
P
--------
N
A
P
V
K
I
T
D
F
G
L
A
V
I
M
E
Q
GPTY-
F
-----
G
-----
F
----
A
G
T
P
G
Y
L
S
P
E
V
I
R
-------
R
V
P
Y
D
T
A
V
D
V
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
E
E
D
H
Q
K
L
Y
A
Q
I
K
N
C
Q
Y
D
F
P
S
P
E
W
D
S
V
T
T
A
A
K
E
L
I
K
A
M
L
E
P
N
P
K
R
R
P
T
V
Q
E
L
L
Q
H
P
W
I
----
A
R
R
D
---
V
---
P
------
G
SV
H
-----
R
Q
A
T
L
E
E
----
L
K
K
F
N
A
R
R
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
77.85
26%
-38
- C1 -
-
3Q5I
1
?
A:
[29-480]
-------------
K
K
E
G
K
I
G
E
S
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
---------------
K
F
H
E
E
I
Y
N
E
I
S
L
L
K
S
L
-
D
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
H
----
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
N
S
--------
L
L
N
I
K
I
V
D
F
G
L
S
S
F
F
S
K
D
Y
K
L
-
R
-----
D
-----
R
----
L
G
T
A
Y
Y
I
A
P
E
V
L
K
--------
K
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
---
G
Q
N
D
Q
D
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
A
L
N
S
R
W
I
----
K
K
Y
A
---
N
---
N
INKSD
Q
K
--
T
-----
L
C
G
A
L
S
N
----
M
R
K
F
E
G
S
Q
K
L
A
Q
A
A
I
L
F
I
G
S
K
L
T
T
L
E
E
R
K
E
L
T
D
I
F
K
K
L
D
K
N
G
D
--
G
Q
L
D
K
K
E
-----
L
I
E
G
Y
N
V
L
R
N
F
KLGELKN
V
E
E
E
V
D
N
I
L
K
E
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
I
S
V
C
M
D
K
Q
I
L
F
S
E
E
R
L
------
R
R
A
F
N
L
F
D
T
D
K
SG
K
I
T
K
E
E
L
A
N
L
F
G
L
T
S
I
S
E
K
T
W
N
D
V
L
G
E
A
D
Q
-------------------------------------------------------------------------------------------------------------------
35
HHSearch
77.41
39%
-75
- C1 -
-
5IG1
-
?
B:
[15-307]
------------------
D
V
D
L
K
D
K
R
S
V
I
G
K
G
A
F
S
T
V
H
R
C
V
N
K
R
T
G
E
V
C
A
V
K
V
I
A
L
K
S
L
R
------
S
----
S
E
I
N
K
I
K
R
E
I
G
I
C
S
S
L
-
Q
H
E
H
I
V
S
M
R
R
A
F
R
D
E
S
H
F
Y
L
V
F
E
Y
V
S
G
G
E
L
F
D
E
I
V
T
R
K
----
F
Y
N
E
K
D
A
S
A
C
M
H
Q
I
L
S
A
L
Q
H
C
H
S
K
N
I
I
H
R
D
L
K
P
E
N
L
L
L
A
S
K
D
P
--------
N
A
P
V
K
I
T
D
F
G
L
A
V
I
M
E
Q
GPTY-
F
-----
G
-----
F
----
A
G
T
P
G
Y
L
S
P
E
V
I
R
-------
R
V
P
Y
D
T
A
V
D
V
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
E
E
D
H
Q
K
L
Y
A
Q
I
K
N
C
Q
Y
D
F
P
S
P
E
W
D
S
V
T
T
A
A
K
E
L
I
K
A
M
L
E
P
N
P
K
R
R
P
T
V
Q
E
L
L
Q
H
P
W
I
----
A
R
R
D
---
V
---
P
------
G
SV
H
-----
R
Q
A
T
L
E
E
----
L
K
K
F
N
A
R
R
K
L
K
G
G
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
77.25
38%
-94
- C1 -
-
5VLO
2
KCC2D_HUMAN
A:
[11-275]
------------------
F
T
D
E
Y
Q
L
F
E
E
L
G
---
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
H
Q
K
L
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
--------
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
-----
D
-----
Q
QAWF
G
F
----
A
G
T
P
G
Y
L
S
P
E
V
L
-------
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
77.18
38%
-75
- C1 -
-
6BAB
2
KCC2D_MOUSE
B:
[14-301]
---------------------
E
Y
Q
L
F
E
E
L
G
----
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
--------
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
DQQAW
F
-----
G
-----
F
----
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
Q
R
S
---
T
VAS
M
------
M
--
H
-----
R
Q
E
T
V
D
C
----
L
K
K
F
N
A
R
R
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
76.73
38%
-89
- C1 -
-
6BAB
2
KCC2D_MOUSE
A:
[12-275]
-------------------
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
H
Q
K
L
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
--------
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
-----
D
-----
Q
QAWFG
F
----
A
G
T
P
G
Y
L
S
P
E
V
L
-------
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.89
36%
-102
- C1 -
-
2W4O
1
KCC4_HUMAN
A:
[55-340]
----------------------
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
------------------------
I
G
V
L
L
R
L
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
----
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
---
A
T
P
--
A
P
D
A
P
L
K
---
I
A
D
F
-------------------------------
G
T
P
G
Y
C
A
P
E
I
L
-------
R
G
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
DER
G
D
Q
F
--
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
----
T
G
K
A
---
A
---
N
F-----
V
--
H
-----
M
D
T
A
Q
K
K
----
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
73.83
36%
-39
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[20-317]
----------------
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP---
G
----
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
--------
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
SGLV
A
G
-----
G
-----
R
----
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
---
G
T
K
E
-
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
----
K
E
R
D
---
R
---
Y
AYK---
I
--
H
-----
L
P
E
T
V
E
Q
----
L
R
K
F
N
A
R
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
65.64
34%
1
* C1 *
-
4B4L
3
DAPK1_HUMAN
A:
[7-305]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
------
S
SRRG
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
-------
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
F
-
K
-----
N
-----
I
----
F
G
T
P
E
F
V
A
P
E
I
V
N
-------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
P
K
D
---
T
---
Q
------
Q
--
A
L
S
R
K
A
S
A
V
N
M
E
K
----
F
K
K
F
A
A
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
63.92
31%
-36
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[91-364]
-----------------
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
LSPEQL
E
----
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
-----------
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
GEKL-
R
-----
E
-----
L
----
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
-
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
----
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
61.54
31%
-32
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[91-364]
-----------------
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
LSPEQL
E
----
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
-----------
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
GEKL-
R
-----
E
-----
L
----
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
-
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
----
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------