@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LINJ_29_1420: (2018-07-13 )
MPSPCPSSSSPLLGSITSGIRSPSRGPVQQQQQQHQLHAPMRLRLHEDGNIRACPEKSGGGVSQACAPPLPAASAFARGKEEPSAKRHHAEPSSCPAPDGDSSSVGRSAAATAVTIAAPLLSISNPSSRAAPSPFRFLCTSLGGCPVVGAKGARVHLPGSSASCDVSGSVAPRDLSTTSAHSKAHSTAAVVRASPSSGVVSPPLSATYPSLVSASRGARVVCSHPQPASAASVPGAIIDTSAPSPVPSRPHRIHQHELRPADFRREEVLGEGSYSIVTLATHRASGLCFALKEIDRSRLRWRPLEAQLRWEINLQRTLRHPHIVRLYSYFITPDCISLVLEYCSGGTLLSRLRAAPQHRLSERQASRYTRHVAKALTHLHGLGVAHRDLKLENVLIDADGIAKLADFGWSRPVVHPLPPSKSAATTQTAGDRNDVPCSSAEHDTSNEDPTEGVAEGRRTVCGTLDYLSPEMVSGQAHSAKTDVWSLGVMLAEMLTGTPPFYTESTQQTLYAIQRLPPNLTGLRPKGRGPGLTGSGASATANVCLTLDEPVALSAGALSLIHAMLQKDPSARPTMQEVLSHAWLQKTR
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260-----........270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380........390.......---400.......410.......420.......430.......440.......450.......460.......470....----..-.480.......490.......500.......510.......520.......530.......540.......550.......560.......570..-----.......580.....-------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPSPCPSSSSP
L
L
G
S
I
T
S
G
IRSPSRG
P
V
Q
Q
Q
Q
Q
Q
H
QLHA
P
M
R
L
R
LHEDG
N
I
R
ACPEKSGGGVSQACAPPL
P
A
A
S
A
F
ARGKEEPSAKRHHAEPSSCPAPDGDSSSVGRSAA
A
T
A
V
T
I
A
A
P
L
L
SISNPSSRAAPS
P
F
R
F
L
C
T
SLGGCPVVGAKG
A
R
V
HLPGSSASCDVSGSVAPRDLSTTSAHSKAHS
T
A
A
V
V
RASPSSGVVSPPLS
A
T
Y
P
S
L
V
SASRG
A
R
V
V
C
SHPQPASAASVP
G
A
I
IDTSAPSPVPSRPHR
I
H
QHELRP
A
------
D
F
R
R
E
E
VLGEGS
Y
S
I
V
T
L
ATHRAS
G
L
C
F
A
L
K
E
I
D
R
S
RLRWRPL
E
A
Q
L
R
W
E
I
N
L
Q
R
TLRH
P
H
I
V
R
L
Y
S
Y
FI
T
P
D
C
I
S
L
V
L
E
YCS
G
G
T
L
L
S
R
L
RAA
P
Q
H
R
L
S
E
R
Q
A
S
R
Y
T
R
H
V
A
K
A
L
T
H
L
H
G-LGVAHRD
L
K
L
E
N
V
L
IDA
D
---
G
I
A
K
L
A
DFGWSRPVVHPLPPSKSAATTQTAGDRNDVPCSSAEHDTSNEDPT
E
G
V
A
EG
R
R
T
VCGTLDYL
S
P
E
MVSGQA----HS-AK
T
D
V
W
S
L
G
V
M
L
A
E
M
LTGTPPFYTE
S
T
Q
Q
T
L
Y
A
I
Q
RLPPNLTGLRPKGRGPGLTGSGAS
A
T
A
N
V
C
L
TLDEPVAL
S
A
G
A
L
S
L
I
H
A
M
L
QKDPSA--R
P
-----
T
M
Q
E
V
L
S
H
A
W
LQKTR-------------------------------------------------------------------
10
PsiBlast_PDB
74.16
33%
-117
- C1 -
-
4ZS0
1
AURKA_HUMAN
A:
[14-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
-
P
S
S
R
-----------------------------------
R
-----
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
----
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
-----------------------------
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------
13
PsiBlast_PDB
72.19
33%
-125
- C1 -
-
4ZTS
2
AURKA_HUMAN
A:
[14-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
F
G
W
S
----------------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
----
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
-----------------------------
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------
18
PsiBlast_PDB
72.14
33%
-112
- C1 -
-
3UO4
4
AURKA_HUMAN
A:
[10-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
-
P
S
S
R
-----------------------------------
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
----
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
-----------------------------
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------
16
PsiBlast_PDB
70.86
33%
-113
- C1 -
-
4O0S
1
AURKA_HUMAN
A:
[11-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
-
P
S
S
R
-----------------------------------
R
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
----
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
-----------------------------
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------
19
PsiBlast_PDB
70.62
33%
-113
- C1 -
-
3UO5
1
AURKA_HUMAN
A:
[10-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
-
P
S
S
R
-----------------------------------
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
----
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
-----------------------------
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------
6
PsiBlast_PDB
70.52
33%
-114
- C1 -
-
2X6D
1
AURKA_HUMAN
A:
[14-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
----
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
-
P
S
S
R
---------------------------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
----
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
-----------------------------
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------
4
PsiBlast_PDB
70.18
33%
-120
- C1 -
-
2XNG
1
AURKA_HUMAN
A:
[12-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
----------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
----
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
-----------------------------
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------
15
PsiBlast_PDB
70.11
33%
-124
- C1 -
-
4C3P
1
AURKA_HUMAN
A:
[11-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
-
P
S
S
R
-----------------------------------
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
----
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
-----------------------------
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------
47
Fugue
69.50
35%
-
- C1 -
-
3H4J
-
SNF1_SCHPO
B:
[27-356]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
H
I
G
------
P
Y
I
I
R
E
T
L
G
E
G
S
F
G
K
V
K
L
A
T
H
Y
K
T
Q
Q
K
V
A
L
K
F
I
S
R
Q
L
L
K
K
S
D
M
H
M
R
V
E
R
E
I
S
Y
L
K
L
L
R
H
P
H
I
I
K
L
Y
D
V
I
T
T
P
T
D
I
V
M
V
I
E
Y
A
-
G
G
E
L
F
D
Y
I
V
E
K
--
K
R
M
T
E
D
E
G
R
R
F
F
Q
Q
I
I
C
A
I
E
Y
C
H
R
-
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
D
D
N
---
L
N
V
K
I
A
D
F
G
L
S
N
I
M
--------------
T
D
G
N
F
L
K
------------------------
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
N
G
K
L
----
Y
A
G
P
E
V
D
V
W
S
C
G
I
V
L
Y
V
M
L
V
G
R
L
P
F
D
D
E
F
I
P
N
L
F
K
K
V
N
S
C
V
Y
V
M
-----------------------------
P
D
F
L
S
P
G
A
Q
S
L
I
R
R
M
I
V
A
D
P
M
Q
--
R
I
-----
T
I
Q
E
I
R
R
D
P
W
F
N
V
N
L
PDYLRPMEEVQGSYADSRIVSKLGEAMGFSEDYIVEALRSDENNEVKEAYNLLHENQVIQEKLEHHH
12
PsiBlast_PDB
69.32
33%
-123
- C1 -
-
4ZTR
1
AURKA_HUMAN
A:
[14-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
F
G
W
----------------------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
----
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
-----------------------------
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------
11
PsiBlast_PDB
68.87
33%
-128
- C1 -
-
4ZTQ
2
AURKA_HUMAN
A:
[14-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
F
G
W
S
---
V
-----------------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
---------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
-----------------------------
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------
8
PsiBlast_PDB
68.86
33%
-119
- C1 -
-
4BYI
1
AURKA_HUMAN
A:
[14-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
---------------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
----
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
-----------------------------
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------
36
HHSearch
68.82
31%
-55
* C1 *
-
4GV1
5
AKT1_HUMAN
A:
[7-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
------
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
---
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
-------------------------------------
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
-----------------------------
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
---------------------------------------------------------------------
41
HHSearch
68.66
31%
-72
- C1 -
-
3V8S
1
ROCK1_HUMAN
D:
[66-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
E
------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
---
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
---
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
------------------------------------
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY
Y
G
-
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
-------------------------
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
-----
G
V
E
E
I
K
R
H
L
F
F
K
N
---------------------------------------------------------------------
24
HHSearch
67.27
31%
-78
- C1 -
-
4WOT
1
ROCK2_HUMAN
B:
[66-337]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
E
------
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
---
Y
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
---
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
------------------------------------
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGF
Y
G
-
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
D
H
K
N
S
L
-------------------------
C
F
P
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
-----
G
V
E
E
I
R
Q
H
P
F
F
K
N
---------------------------------------------------------------------
17
PsiBlast_PDB
67.13
33%
-113
- C1 -
-
3UNZ
3
AURKA_HUMAN
A:
[10-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
-
P
S
S
R
-----------------------------------
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
----
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
-----------------------------
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------
9
PsiBlast_PDB
66.94
33%
-121
- C1 -
-
4BYJ
1
AURKA_HUMAN
A:
[14-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
--------------------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
----
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
-----------------------------
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------
39
HHSearch
66.42
34%
-153
- C1 -
-
4JXF
2
PLK4_HUMAN
A:
[6-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
------
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
-
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
---
M
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
M
P
H
-------------------------------------
E
------------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----
V
K
N
T
L
N
K
V
V
L
A
-----------------------------
D
Y
E
M
P
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
--
R
L
-----
S
L
S
S
V
L
D
H
P
F
M
S
R
---------------------------------------------------------------------
14
PsiBlast_PDB
65.87
33%
-125
- C1 -
-
5ONE
1
AURKA_HUMAN
A:
[14-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
F
G
W
S
---
V
H
--------------------------------------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
----
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
-----------------------------
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------
37
HHSearch
65.58
31%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[4-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
------
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
-
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
SKG
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
-------------------------------------
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
----
Y
G
-
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
-------------------------
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
--
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
---------------------------------------------------------------------
20
PsiBlast_PDB
65.18
33%
-111
- C1 -
-
3UO6
3
AURKA_HUMAN
A:
[10-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
-
P
S
S
R
-----------------------------------
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
----
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
-----------------------------
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------
5
PsiBlast_PDB
64.45
33%
-122
- C1 -
-
4B0G
1
AURKA_HUMAN
A:
[12-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
----
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
F
G
W
S
---
V
------------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
-------
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
-----------------------------
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------
2
PsiBlast_PDB
62.73
33%
-123
- C1 -
-
1MUO
1
AURKA_HUMAN
A:
[26-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
F
G
W
S
-------------------------------------------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
----
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
-----------------------------
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------
1
PsiBlast_PDB
58.22
32%
11
- C1 -
-
2J4Z
3
AURKA_HUMAN
A:
[29-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RQWALE
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
-
P
S
S
R
-----------------------------------
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
----
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
---------------------------
V
E
F
T
F
--
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
-----------------------------------------------------------------------