@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : UBP7_HUMAN: (2018-10-06 )
MNHQQQQQQQKAGEQQLSEPEDMEMEAGDTDDPPRITQNPVINGNVALSDGHNTAEEDMEDDTSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFYPDRPHQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKRKERQEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVKYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTKRPAMLDNEADGNKTMIELSDNENPWTIFLETVDPELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVMCDRAGFIQDTSLILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSELPTAKEYFRDLYHRVDVIFCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFFKSQGYRDGPGNPLRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLNSQFREEEITLYPDKHGCVRDLLEECKKAVELGEKASGKLRLLEIVSYKIIGVHQEDELLECLSPATSRTFRIEEIPLDQVDIDKENEMLVTVAHFHKEVFGTFGIPFLLRIHQGEHFREVMKRIQSLLDIQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLDHFNKAPKRSRYTYLEKAIKIHN
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MN
H
Q
Q
Q
Q
Q
Q
Q
K
A
G
E
Q
QLSEPEDMEMEAGDTDDPPRITQNPVING
N
V
A
LSDGHN
T
A
E
E
DMEDDTSWRS
E
A
T
F
Q
F
T
V
E
R
F
S
R
L
S
E
S
VLSPPCFVRNL
P
W
K
I
M
V
M
PRFYPDRPHQKSV
G
F
F
L
Q
CNAESDSTSW
S
C
H
A
Q
A
V
L
K
I
INYRD
D
E
K
S
F
S
R
R
I
S
H
L
F
F
HKENDWGFSN
F
M
AWSEVTDPEKGFIDDD
K
V
T
F
E
V
F
V
QADAPHGVAWDSKKHT
G
Y
VGLKNQ
G
A
T
C
Y
M
N
S
L
L
Q
T
L
F
F
T
N
Q
L
R
K
A
V
Y
MMPTEGDDSSKS
V
P
L
A
L
Q
R
V
F
Y
E
L
QHSDKPV
G
T
K
K
L
T
K
SF
G
W
E
T
L
D
S
F
M
Q
H
D
V
Q
E
L
C
R
V
L
L
D
N
V
E
N
K
MKGTCVEG
T
I
P
K
L
F
RGK
M
V
S
Y
I
Q
C
KEVDYRSDRRE
D
Y
Y
D
I
Q
L
S
IKG
K
K
N
I
F
E
S
F
V
D
Y
V
A
V
E
QLDGDNKY
D
A
G
E
H
G
L
Q
E
A
E
KG
V
K
F
LTLP
P
V
L
H
L
Q
L
M
R
F
MYDPQTDQ
N
I
K
INDRFEFPEQL
P
L
D
E
F
L
Q
KTDPK
D
P
A
N
Y
I
L
H
A
V
L
V
HSGDNHG
G
H
Y
V
V
Y
L
NPKGDGKWCKF
D
D
D
V
V
S
R
C
T
K
E
E
AIEHNYGGHDDDLS
V
R
HCTN
A
Y
M
L
V
Y
I
R
E
S
K
L
S
E
V
L
Q
A
V
TD
H
D
I
P
Q
Q
L
V
E
R
L
Q
E
E
K
R
I
E
A
Q
K
R
K
E
R
Q
EA
H
L
Y
M
Q
V
Q
I
V
AEDQFCGHQGNDM
Y
D
E
E
K
V
K
Y
T
V
F
K
V
LKN
S
S
L
A
E
F
V
Q
S
L
S
Q
TMGF
P
Q
D
Q
I
R
L
W
P
M
QARSNGTKRPAMLDNEADG
N
K
T
M
I
E
LSDNEN
P
W
T
I
F
L
ETV
D
P
E
L
AASGATLPKFDKDH
D
V
M
L
F
L
K
MYDPKTRSLNYCGHIYTPI
S
C
K
I
R
D
L
L
P
V
M
CDRAGFIQD
T
S
L
I
L
Y
E
EVKP
N
L
T
E
R
I
Q
D
YDV
S
L
D
K
A
L
D
E
LMDG
D
I
I
V
F
QKDDPENDNSELP
T
A
K
E
Y
F
R
D
L
Y
HRV
D
V
I
F
CDKTIPNDP
G
F
V
V
T
LSNRM
N
Y
F
Q
V
A
K
T
V
A
Q
RLNT
D
P
M
L
L
Q
F
F
K
SQGYRDGPGNPLRHNY
E
G
T
L
R
D
L
L
Q
F
FKPRQ
P
K
K
L
Y
Y
Q
Q
L
K
M
K
ITDFEN
R
R
S
F
K
C
I
WLNSQFREE
E
I
T
LYPDKH
G
C
V
R
D
L
L
E
E
C
K
K
A
V
EL
G
E
KASG
K
L
R
L
L
E
I
V
S
Y
K
I
I
G
VH
Q
E
D
E
L
L
E
C
LSPATS
R
T
F
R
I
E
EIPLDQVDIDKEN
E
M
L
V
T
V
A
H
F
H
K
E
V
F
G
TF
G
I
P
F
L
L
RIHQ
G
E
H
F
R
E
V
M
K
R
I
Q
S
L
L
D
I
Q
E
K
E
F
E
K
F
K
F
A
I
V
M
MGRHQYINED
E
Y
E
V
NLKDFEPQPGNMSHPRPWLG
L
D
H
FNKAPK
R
S
R
Y
T
Y
L
E
K
A
I
KIHN
2
PsiBlast_PDB
92.19
100%
-105
- C4 -
-
5J7T
-
UBP7_HUMAN
A:
[1-671]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
Y
V
G
L
K
N
Q
G
A
T
C
Y
M
N
S
L
L
Q
T
L
F
F
T
N
Q
L
R
K
A
V
Y
M
M
P
T
E
G
D
D
S
S
K
S
V
P
L
A
L
Q
R
V
F
Y
E
L
Q
H
S
D
K
P
V
G
T
K
K
L
T
K
S
F
G
W
E
T
L
D
S
F
M
Q
H
D
V
Q
E
L
C
R
V
L
L
D
N
V
E
N
K
M
K
G
T
C
V
E
G
T
I
P
K
L
F
R
G
K
M
V
S
Y
I
Q
C
K
E
V
D
Y
R
S
D
R
R
E
D
Y
Y
D
I
Q
L
S
I
K
G
K
K
N
I
F
E
S
F
V
D
Y
V
A
V
E
Q
L
D
G
D
N
K
Y
D
A
G
E
H
G
L
Q
E
A
E
K
G
V
K
F
L
T
L
P
P
V
L
H
L
Q
L
M
R
F
M
Y
D
P
Q
T
D
Q
N
I
K
I
N
D
R
F
E
F
P
E
Q
L
P
L
D
E
F
L
Q
K
T
D
P
K
D
P
A
N
Y
I
L
H
A
V
L
V
H
S
G
D
N
H
G
G
H
Y
V
V
Y
L
N
P
K
G
D
G
K
W
C
K
F
D
D
D
V
V
S
R
C
T
K
E
E
A
I
E
H
N
Y
G
G
H
D
D
D
L
S
V
R
H
C
T
N
A
Y
M
L
V
Y
I
R
E
S
K
L
S
E
V
L
Q
A
V
T
D
H
D
I
P
Q
Q
L
V
E
R
L
Q
E
E
K
R
I
E
A
Q
K
R
K
E
R
Q
E
A
H
L
Y
M
Q
V
Q
I
V
A
E
D
Q
F
C
G
H
Q
G
N
D
M
Y
D
E
E
K
V
K
Y
T
V
F
K
V
L
K
N
S
S
L
A
E
F
V
Q
S
L
S
Q
T
M
G
F
P
Q
D
Q
I
R
L
W
P
M
Q
A
R
S
N
G
T
K
R
P
A
M
L
D
N
E
A
D
G
N
K
T
M
I
E
L
S
D
N
E
N
P
W
T
I
F
L
E
T
V
D
P
E
L
A
A
S
G
A
T
L
P
K
F
D
K
D
H
D
V
M
L
F
L
K
M
Y
D
P
K
T
R
S
L
N
Y
C
G
H
I
Y
T
P
I
S
C
K
I
R
D
L
L
P
V
M
C
D
R
A
G
F
I
Q
D
T
S
L
I
L
Y
E
E
V
K
P
N
L
T
E
R
I
Q
D
Y
D
V
S
L
D
K
A
L
D
E
L
M
D
G
D
I
I
V
F
Q
K
D
D
P
E
N
D
N
S
E
L
P
T
A
K
E
Y
F
R
D
L
Y
H
R
V
D
V
I
F
C
D
K
T
I
P
N
D
P
G
F
V
V
T
L
S
N
R
M
N
Y
F
Q
V
A
K
T
V
A
Q
R
L
N
T
D
P
M
L
L
Q
F
F
K
S
Q
G
Y
R
D
G
P
G
N
P
L
R
H
N
Y
E
G
T
L
R
D
L
L
Q
F
F
K
P
R
Q
P
K
K
L
Y
Y
Q
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.45
100%
-103
- C4 -
-
5FWI
-
UBP7_HUMAN
C:
[8-679]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
T
G
Y
V
G
L
K
N
Q
G
A
T
C
Y
M
N
S
L
L
Q
T
L
F
F
T
N
Q
L
R
K
A
V
Y
M
M
P
T
E
G
D
D
S
S
K
S
V
P
L
A
L
Q
R
V
F
Y
E
L
Q
H
S
D
K
P
V
G
T
K
K
L
T
K
S
F
G
W
E
T
L
D
S
F
M
Q
H
D
V
Q
E
L
C
R
V
L
L
D
N
V
E
N
K
M
K
G
T
C
V
E
G
T
I
P
K
L
F
R
G
K
M
V
S
Y
I
Q
C
K
E
V
D
Y
R
S
D
R
R
E
D
Y
Y
D
I
Q
L
S
I
K
G
K
K
N
I
F
E
S
F
V
D
Y
V
A
V
E
Q
L
D
G
D
N
K
Y
D
A
G
E
H
G
L
Q
E
A
E
K
G
V
K
F
L
T
L
P
P
V
L
H
L
Q
L
M
R
F
M
Y
D
P
Q
T
D
Q
N
I
K
I
N
D
R
F
E
F
P
E
Q
L
P
L
D
E
F
L
Q
K
T
D
P
K
D
P
A
N
Y
I
L
H
A
V
L
V
H
S
G
--
H
G
G
H
Y
V
V
Y
L
N
P
K
G
D
G
K
W
C
K
F
D
D
D
V
V
S
R
C
T
K
E
E
A
I
E
H
N
Y
G
G
--------
H
C
T
N
A
Y
M
L
V
Y
I
R
E
S
K
L
S
E
V
L
Q
A
V
T
D
H
D
I
P
Q
Q
L
V
E
R
L
Q
E
E
K
R
I
E
A
Q
K
R
K
E
R
Q
E
A
H
L
Y
M
Q
V
Q
I
V
A
E
D
Q
F
C
G
H
Q
G
N
D
M
Y
D
E
E
K
V
K
Y
T
V
F
K
V
L
K
N
S
S
L
A
E
F
V
Q
S
L
S
Q
T
M
G
F
P
Q
D
Q
I
R
L
W
P
M
Q
A
R
S
N
G
T
K
R
P
A
M
L
D
N
E
A
D
G
N
K
T
M
I
E
L
S
D
N
E
N
P
W
T
I
F
L
E
T
V
D
P
E
L
A
A
S
G
A
T
L
P
K
F
D
K
D
H
D
V
M
L
F
L
K
M
Y
D
P
K
T
R
S
L
N
Y
C
G
H
I
Y
T
P
I
S
C
K
I
R
D
L
L
P
V
M
C
D
R
A
G
F
I
Q
D
T
S
L
I
L
Y
E
E
V
K
P
N
L
T
E
R
I
Q
D
Y
D
V
S
L
D
K
A
L
D
E
L
M
D
G
D
I
I
V
F
Q
K
D
D
P
E
N
D
N
S
E
L
P
T
A
K
E
Y
F
R
D
L
Y
H
R
V
D
V
I
F
C
D
K
T
I
P
N
D
P
G
F
V
V
T
L
S
N
R
M
N
Y
F
Q
V
A
K
T
V
A
Q
R
L
N
T
D
P
M
L
L
Q
F
F
K
S
Q
G
Y
R
D
G
P
G
N
P
L
R
H
N
Y
E
G
T
L
R
D
L
L
Q
F
F
K
P
R
Q
P
K
K
L
Y
Y
Q
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
83.91
98%
-103
- C4 -
-
5JTV
-
?
E:
[18-594]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
T
G
Y
V
G
L
K
N
Q
G
A
T
C
Y
M
N
S
L
L
Q
T
L
F
F
T
N
Q
L
R
K
A
V
Y
M
M
P
T
E
G
D
D
S
S
K
S
V
P
L
A
L
Q
R
V
F
Y
E
L
Q
H
S
D
K
P
V
G
T
K
K
L
T
K
S
F
G
W
E
T
L
D
S
F
M
Q
H
D
V
Q
E
L
C
R
V
L
L
D
N
V
E
N
K
M
K
G
T
C
V
E
G
T
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L
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Y
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C
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Y
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D
R
R
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Y
Y
D
I
Q
L
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K
G
K
K
N
I
F
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F
V
D
Y
V
A
V
E
Q
L
D
G
D
N
K
Y
D
A
G
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H
G
L
Q
E
A
E
K
G
V
K
F
L
T
L
P
P
V
L
H
L
Q
L
M
R
F
M
Y
D
P
Q
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N
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D
R
F
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F
P
E
Q
L
P
L
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F
L
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K
T
D
P
K
D
P
A
N
Y
I
L
H
A
V
L
V
H
S
G
D
N
H
G
G
H
Y
V
V
Y
L
N
P
K
G
D
G
K
W
C
K
F
D
D
D
V
V
S
R
C
T
K
E
E
A
I
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N
Y
G
G
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D
D
D
L
S
V
R
H
C
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N
A
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M
L
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Y
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S
K
L
S
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V
L
Q
A
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D
H
D
I
P
Q
Q
L
V
E
R
L
Q
E
E
K
R
I
E
A
Q
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
T
D
F
E
N
R
R
S
F
K
C
I
W
L
N
S
Q
F
R
E
E
E
I
T
L
Y
P
D
K
H
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C
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R
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L
L
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C
K
K
A
V
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L
G
E
K
A
S
G
K
L
R
L
L
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I
V
S
Y
K
I
I
G
V
H
Q
E
D
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L
L
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C
L
S
P
A
T
S
R
T
F
R
I
E
E
I
P
L
D
Q
V
D
I
D
K
E
N
E
M
L
V
T
V
A
H
F
H
K
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V
F
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L
L
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I
H
Q
G
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F
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M
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R
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L
L
D
I
Q
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K
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K
F
K
F
A
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V
M
M
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Y
I
N
E
D
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Y
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L
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Q
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N
M
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H
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L
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L
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N
K
A
P
K
R
S
R
Y
T
Y
L
E
K
A
I
K
I
H
N
22
HHSearch
83.02
98%
-105
- C4 -
-
5JTV
-
?
G:
[18-594]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
T
G
Y
V
G
L
K
N
Q
G
A
T
C
Y
M
N
S
L
L
Q
T
L
F
F
T
N
Q
L
R
K
A
V
Y
M
M
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D
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L
A
L
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K
P
V
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T
K
K
L
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K
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G
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T
L
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S
F
M
Q
H
D
V
Q
E
L
C
R
V
L
L
D
N
V
E
N
K
M
K
G
T
C
V
E
G
T
I
P
K
L
F
R
G
K
M
V
S
Y
I
Q
C
K
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V
D
Y
R
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D
R
R
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Y
Y
D
I
Q
L
S
I
K
G
K
K
N
I
F
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F
V
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Y
V
A
V
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Q
L
D
G
D
N
K
Y
D
A
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H
G
L
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E
A
E
K
G
V
K
F
L
T
L
P
P
V
L
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L
Q
L
M
R
F
M
Y
D
P
Q
T
D
Q
N
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F
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L
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L
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K
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A
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Y
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L
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A
V
L
V
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V
Y
L
N
P
K
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D
G
K
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D
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V
V
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C
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E
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A
I
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N
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G
G
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D
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L
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L
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L
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A
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H
D
I
P
Q
Q
L
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E
R
L
Q
E
E
K
R
I
E
A
Q
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
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D
F
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N
R
R
S
F
K
C
I
W
L
N
S
Q
F
R
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E
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L
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L
L
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K
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L
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A
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G
K
L
R
L
L
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I
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Y
K
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L
L
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L
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A
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I
P
L
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D
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M
L
V
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A
H
F
H
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F
G
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F
G
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L
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F
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M
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M
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Y
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N
L
K
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M
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H
P
R
P
W
L
G
L
D
H
F
N
K
A
P
K
R
S
R
--
Y
L
E
K
A
I
K
I
H
N
6
PsiBlast_PDB
75.64
99%
-121
- C4 -
-
2F1Z
-
UBP7_HUMAN
A:
[64-551]
---------------------------------------------------------------
S
W
R
S
E
A
T
F
Q
F
T
V
E
R
F
S
R
L
S
E
S
V
L
S
P
P
C
F
V
R
N
L
P
W
K
I
M
V
M
P
R
--------
K
S
V
G
F
F
L
Q
C
N
A
E
S
D
S
T
S
W
S
C
H
A
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A
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L
K
I
I
N
Y
R
D
D
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R
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L
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F
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K
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D
W
G
F
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F
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A
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V
T
D
P
E
K
G
F
I
D
D
D
K
V
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F
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F
V
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A
D
A
P
H
G
V
A
W
D
S
K
K
H
T
G
Y
V
G
L
K
N
Q
--
T
C
Y
M
N
S
L
L
Q
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L
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F
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Q
L
R
K
A
V
Y
M
M
P
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G
D
D
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P
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A
L
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V
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Y
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L
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K
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L
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V
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P
K
L
F
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Y
R
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D
R
R
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D
Y
Y
D
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Q
L
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K
G
K
K
N
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F
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F
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A
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D
N
K
Y
D
A
G
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H
G
L
Q
E
A
E
K
G
V
K
F
L
T
L
P
P
V
L
H
L
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L
M
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M
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D
P
Q
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D
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N
I
K
I
N
D
R
F
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F
P
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Q
L
P
L
D
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F
L
Q
K
T
D
P
K
D
P
A
N
Y
I
L
H
A
V
L
V
H
S
G
D
N
H
G
G
H
Y
V
V
Y
L
N
P
K
G
D
G
K
W
C
K
F
D
D
D
V
V
S
R
C
T
K
E
E
A
I
E
H
N
Y
G
G
--------
H
C
T
N
A
Y
M
L
V
Y
I
R
E
S
K
L
S
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V
L
Q
A
V
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D
H
D
I
P
Q
Q
L
V
E
R
L
Q
E
E
K
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
74.85
100%
-114
- C4 -
-
2F1Z
-
UBP7_HUMAN
B:
[63-553]
--------------------------------------------------------------
T
S
W
R
S
E
A
T
F
Q
F
T
V
E
R
F
S
R
L
S
E
S
V
L
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P
C
F
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L
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M
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S
W
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C
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A
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A
V
L
K
I
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Y
R
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R
R
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S
H
L
F
F
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K
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D
W
G
F
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N
F
M
A
W
S
E
V
T
D
P
E
K
G
F
I
D
D
D
K
V
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F
E
V
F
V
Q
A
D
A
P
H
G
V
A
W
D
S
K
K
H
T
G
Y
V
G
L
K
N
Q
G
A
T
C
Y
M
N
S
L
L
Q
T
L
F
F
T
N
Q
L
R
K
A
V
Y
M
M
P
T
E
G
D
D
S
S
K
S
V
P
L
A
L
Q
R
V
F
Y
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L
Q
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K
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G
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K
K
L
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L
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V
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K
M
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G
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Y
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R
R
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D
Y
Y
D
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L
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A
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L
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D
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G
L
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A
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G
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L
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L
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M
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D
P
Q
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D
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I
K
I
N
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F
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F
P
E
Q
L
P
L
D
E
F
L
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K
T
D
P
K
D
P
A
N
Y
I
L
H
A
V
L
V
H
S
G
D
N
H
G
G
H
Y
V
V
Y
L
N
P
K
G
D
G
K
W
C
K
F
D
D
D
V
V
S
R
C
T
K
E
E
A
I
E
H
N
Y
G
----------
C
T
N
A
Y
M
L
V
Y
I
R
E
S
K
L
S
E
V
L
Q
A
V
T
D
H
D
I
P
Q
Q
L
V
E
R
L
Q
E
E
K
R
I
E
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
73.28
99%
-115
- C3 -
-
2YLM
-
A:
[3-529]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
E
A
H
L
Y
M
Q
V
Q
I
V
A
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D
Q
F
C
G
H
Q
G
N
D
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D
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A
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D
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Y
C
G
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Y
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K
I
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D
L
L
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A
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L
I
L
Y
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E
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D
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L
D
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A
L
D
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L
M
D
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D
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D
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D
N
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L
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A
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F
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M
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L
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K
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Y
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L
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L
L
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V
H
Q
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D
E
L
L
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C
L
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A
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S
R
T
F
R
I
E
E
I
P
L
D
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D
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M
L
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V
A
H
F
H
K
E
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F
G
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F
G
I
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F
L
L
R
I
H
Q
G
E
H
F
R
E
V
M
K
R
I
Q
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L
L
D
I
Q
E
K
E
F
E
K
F
K
F
A
I
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M
M
G
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H
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Y
I
N
E
D
E
Y
E
V
N
L
K
D
F
E
P
Q
P
G
N
M
S
H
P
R
P
W
L
G
L
D
H
F
N
-------------------
45
Fugue
73.00
99%
-115
- C3 -
-
2YLM
-
A:
[1-529]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
G
S
E
A
H
L
Y
M
Q
V
Q
I
V
A
E
D
Q
F
C
G
H
Q
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N
D
M
Y
D
E
E
K
V
K
Y
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S
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A
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A
A
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A
T
L
P
K
F
D
K
D
H
D
V
M
L
F
L
K
M
Y
D
P
K
T
R
S
L
N
Y
C
G
H
I
Y
T
P
I
S
C
K
I
R
D
L
L
P
V
M
C
D
R
A
G
F
I
Q
D
T
S
L
I
L
Y
E
E
V
K
P
N
L
T
E
R
I
Q
D
Y
D
V
S
L
D
K
A
L
D
E
L
M
D
G
D
I
I
V
F
Q
K
D
D
P
E
N
D
N
S
E
L
P
T
A
K
E
Y
F
R
D
L
Y
H
R
V
D
V
I
F
C
D
K
T
I
P
N
D
P
G
F
V
V
T
L
S
N
R
M
N
Y
F
Q
V
A
K
T
V
A
Q
R
L
N
T
D
P
M
L
L
Q
F
F
K
S
Q
G
Y
R
D
G
P
G
N
P
L
R
H
N
Y
E
G
T
L
R
D
L
L
Q
F
F
K
P
R
Q
P
K
K
L
Y
Y
Q
Q
L
K
M
K
I
T
D
F
E
N
R
R
S
F
K
C
I
W
L
N
S
Q
F
R
E
E
E
I
T
L
Y
P
D
K
H
G
C
V
R
D
L
L
E
E
C
K
K
A
V
E
L
G
E
K
A
S
G
K
L
R
L
L
E
I
V
S
Y
K
I
I
G
V
H
Q
E
D
E
L
L
E
C
L
S
P
A
T
S
R
T
F
R
I
E
E
I
P
L
D
Q
V
D
I
D
K
E
N
E
M
L
V
T
V
A
H
F
H
K
E
V
F
G
T
F
G
I
P
F
L
L
R
I
H
Q
G
E
H
F
R
E
V
M
K
R
I
Q
S
L
L
D
I
Q
E
K
E
F
E
K
F
K
F
A
I
V
M
M
G
R
H
Q
Y
I
N
E
D
E
Y
E
V
N
L
K
D
F
E
P
Q
P
G
N
M
S
H
P
R
P
W
L
G
L
D
H
F
N
-------------------
5
PsiBlast_PDB
72.84
100%
-115
- C3 -
-
2YLM
-
A:
[6-529]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
H
L
Y
M
Q
V
Q
I
V
A
E
D
Q
F
C
G
H
Q
G
N
D
M
Y
D
E
E
K
V
K
Y
T
V
F
K
V
L
K
N
S
S
L
A
E
F
V
Q
S
L
S
Q
T
M
G
F
P
Q
D
Q
I
R
L
W
P
M
Q
A
R
S
N
G
T
K
R
P
A
M
L
D
N
E
A
D
G
N
K
T
M
I
E
L
S
D
N
E
N
P
W
T
I
F
L
E
T
V
D
P
E
L
A
A
S
G
A
T
L
P
K
F
D
K
D
H
D
V
M
L
F
L
K
M
Y
D
P
K
T
R
S
L
N
Y
C
G
H
I
Y
T
P
I
S
C
K
I
R
D
L
L
P
V
M
C
D
R
A
G
F
I
Q
D
T
S
L
I
L
Y
E
E
V
K
P
N
L
T
E
R
I
Q
D
Y
D
V
S
L
D
K
A
L
D
E
L
M
D
G
D
I
I
V
F
Q
K
D
D
P
E
N
D
N
S
E
L
P
T
A
K
E
Y
F
R
D
L
Y
H
R
V
D
V
I
F
C
D
K
T
I
P
N
D
P
G
F
V
V
T
L
S
N
R
M
N
Y
F
Q
V
A
K
T
V
A
Q
R
L
N
T
D
P
M
L
L
Q
F
F
K
S
Q
G
Y
R
D
G
P
G
N
P
L
R
H
N
Y
E
G
T
L
R
D
L
L
Q
F
F
K
P
R
Q
P
K
K
L
Y
Y
Q
Q
L
K
M
K
I
T
D
F
E
N
R
R
S
F
K
C
I
W
L
N
S
Q
F
R
E
E
E
I
T
L
Y
P
D
K
H
G
C
V
R
D
L
L
E
E
C
K
K
A
V
E
L
G
E
K
A
S
G
K
L
R
L
L
E
I
V
S
Y
K
I
I
G
V
H
Q
E
D
E
L
L
E
C
L
S
P
A
T
S
R
T
F
R
I
E
E
I
P
L
D
Q
V
D
I
D
K
E
N
E
M
L
V
T
V
A
H
F
H
K
E
V
F
G
T
F
G
I
P
F
L
L
R
I
H
Q
G
E
H
F
R
E
V
M
K
R
I
Q
S
L
L
D
I
Q
E
K
E
F
E
K
F
K
F
A
I
V
M
M
G
R
H
Q
Y
I
N
E
D
E
Y
E
V
N
L
K
D
F
E
P
Q
P
G
N
M
S
H
P
R
P
W
L
G
L
D
H
F
N
-------------------
3
PsiBlast_PDB
72.28
100%
-116
- C3 -
-
4YOC
-
C:
[6-529]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
H
L
Y
M
Q
V
Q
I
V
A
E
D
Q
F
C
G
H
Q
G
N
D
M
Y
D
E
E
K
V
K
Y
T
V
F
K
V
L
K
N
S
S
L
A
E
F
V
Q
S
L
S
Q
T
M
G
F
P
Q
D
Q
I
R
L
W
P
M
Q
A
R
S
N
G
T
K
R
P
A
M
L
D
N
E
A
D
G
N
K
T
M
I
E
L
S
D
N
E
N
P
W
T
I
F
L
E
T
V
D
P
E
L
A
A
S
G
A
T
L
P
K
F
D
K
D
H
D
V
M
L
F
L
K
M
Y
D
P
K
T
R
S
L
N
Y
C
G
H
I
Y
T
P
I
S
C
K
I
R
D
L
L
P
V
M
C
D
R
A
G
F
I
Q
D
T
S
L
I
L
Y
E
E
V
K
P
N
L
T
E
R
I
Q
D
Y
D
V
S
L
D
K
A
L
D
E
L
M
D
G
D
I
I
V
F
Q
K
D
D
P
E
N
D
N
S
E
L
P
T
A
K
E
Y
F
R
D
L
Y
H
R
V
D
V
I
F
C
D
K
T
I
P
N
D
P
G
F
V
V
T
L
S
N
R
M
N
Y
F
Q
V
A
K
T
V
A
Q
R
L
N
T
D
P
M
L
L
Q
F
F
K
S
Q
G
Y
R
D
G
P
G
N
P
L
R
H
N
Y
E
G
T
L
R
D
L
L
Q
F
F
K
P
R
Q
P
K
K
L
Y
Y
Q
Q
L
K
M
K
I
T
D
F
E
N
R
R
S
F
K
C
I
W
L
N
S
Q
F
R
E
E
E
I
T
L
Y
P
D
K
H
G
C
V
R
D
L
L
E
E
C
K
K
A
V
E
L
G
E
K
A
S
G
K
L
R
L
L
E
I
V
S
Y
K
I
I
G
V
H
Q
E
D
E
L
L
E
C
L
S
P
A
T
S
R
T
F
R
I
E
E
I
P
L
D
Q
V
D
I
D
K
E
N
E
M
L
V
T
V
A
H
F
H
K
E
V
F
G
T
F
G
I
P
F
L
L
R
I
H
Q
G
E
H
F
R
E
V
M
K
R
I
Q
S
L
L
D
I
Q
E
K
E
F
E
K
F
K
F
A
I
V
M
M
G
R
H
Q
Y
I
N
E
D
E
Y
E
V
N
L
K
D
F
E
P
Q
P
G
N
M
S
H
P
R
P
W
L
G
L
D
H
F
N
-------------------
23
HHSearch
72.01
99%
-115
- C3 -
-
5C56
-
UBP7_HUMAN
A:
[557-1083]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
E
A
H
L
Y
M
Q
V
Q
I
V
A
E
D
Q
F
C
G
H
Q
G
N
D
M
Y
D
E
E
K
V
K
Y
T
V
F
K
V
L
K
N
S
S
L
A
E
F
V
Q
S
L
S
Q
T
M
G
F
P
Q
D
Q
I
R
L
W
P
M
Q
A
R
S
N
G
T
K
R
P
A
M
L
D
N
E
A
D
G
N
K
T
M
I
E
L
S
D
N
E
N
P
W
T
I
F
L
E
T
V
D
P
E
L
A
A
S
G
A
T
L
P
K
F
D
K
D
H
D
V
M
L
F
L
K
M
Y
D
P
K
T
R
S
L
N
Y
C
G
H
I
Y
T
P
I
S
C
K
I
R
D
L
L
P
V
M
C
D
R
A
G
F
I
Q
D
T
S
L
I
L
Y
E
E
V
K
P
N
L
T
E
R
I
Q
D
Y
D
V
S
L
D
K
A
L
D
E
L
M
D
G
D
I
I
V
F
Q
K
D
D
P
E
N
D
N
S
E
L
P
T
A
K
E
Y
F
R
D
L
Y
H
R
V
D
V
I
F
C
D
K
T
I
P
N
D
P
G
F
V
V
T
L
S
N
R
M
N
Y
F
Q
V
A
K
T
V
A
Q
R
L
N
T
D
P
M
L
L
Q
F
F
K
S
Q
G
Y
R
D
G
P
G
N
P
L
R
H
N
Y
E
G
T
L
R
D
L
L
Q
F
F
K
P
R
Q
P
K
K
L
Y
Y
Q
Q
L
K
M
K
I
T
D
F
E
N
R
R
S
F
K
C
I
W
L
N
S
Q
F
R
E
E
E
I
T
L
Y
P
D
K
H
G
C
V
R
D
L
L
E
E
C
K
K
A
V
E
L
G
E
K
A
S
G
K
L
R
L
L
E
I
V
S
Y
K
I
I
G
V
H
Q
E
D
E
L
L
E
C
L
S
P
A
T
S
R
T
F
R
I
E
E
I
P
L
D
Q
V
D
I
D
K
E
N
E
M
L
V
T
V
A
H
F
H
K
E
V
F
G
T
F
G
I
P
F
L
L
R
I
H
Q
G
E
H
F
R
E
V
M
K
R
I
Q
S
L
L
D
I
Q
E
K
E
F
E
K
F
K
F
A
I
V
M
M
G
R
H
Q
Y
I
N
E
D
E
Y
E
V
N
L
K
D
F
E
P
Q
P
G
N
M
S
H
P
R
P
W
L
G
L
D
H
F
N
-------------------
4
PsiBlast_PDB
71.74
100%
-115
- C3 -
-
5C56
-
UBP7_HUMAN
A:
[560-1083]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
H
L
Y
M
Q
V
Q
I
V
A
E
D
Q
F
C
G
H
Q
G
N
D
M
Y
D
E
E
K
V
K
Y
T
V
F
K
V
L
K
N
S
S
L
A
E
F
V
Q
S
L
S
Q
T
M
G
F
P
Q
D
Q
I
R
L
W
P
M
Q
A
R
S
N
G
T
K
R
P
A
M
L
D
N
E
A
D
G
N
K
T
M
I
E
L
S
D
N
E
N
P
W
T
I
F
L
E
T
V
D
P
E
L
A
A
S
G
A
T
L
P
K
F
D
K
D
H
D
V
M
L
F
L
K
M
Y
D
P
K
T
R
S
L
N
Y
C
G
H
I
Y
T
P
I
S
C
K
I
R
D
L
L
P
V
M
C
D
R
A
G
F
I
Q
D
T
S
L
I
L
Y
E
E
V
K
P
N
L
T
E
R
I
Q
D
Y
D
V
S
L
D
K
A
L
D
E
L
M
D
G
D
I
I
V
F
Q
K
D
D
P
E
N
D
N
S
E
L
P
T
A
K
E
Y
F
R
D
L
Y
H
R
V
D
V
I
F
C
D
K
T
I
P
N
D
P
G
F
V
V
T
L
S
N
R
M
N
Y
F
Q
V
A
K
T
V
A
Q
R
L
N
T
D
P
M
L
L
Q
F
F
K
S
Q
G
Y
R
D
G
P
G
N
P
L
R
H
N
Y
E
G
T
L
R
D
L
L
Q
F
F
K
P
R
Q
P
K
K
L
Y
Y
Q
Q
L
K
M
K
I
T
D
F
E
N
R
R
S
F
K
C
I
W
L
N
S
Q
F
R
E
E
E
I
T
L
Y
P
D
K
H
G
C
V
R
D
L
L
E
E
C
K
K
A
V
E
L
G
E
K
A
S
G
K
L
R
L
L
E
I
V
S
Y
K
I
I
G
V
H
Q
E
D
E
L
L
E
C
L
S
P
A
T
S
R
T
F
R
I
E
E
I
P
L
D
Q
V
D
I
D
K
E
N
E
M
L
V
T
V
A
H
F
H
K
E
V
F
G
T
F
G
I
P
F
L
L
R
I
H
Q
G
E
H
F
R
E
V
M
K
R
I
Q
S
L
L
D
I
Q
E
K
E
F
E
K
F
K
F
A
I
V
M
M
G
R
H
Q
Y
I
N
E
D
E
Y
E
V
N
L
K
D
F
E
P
Q
P
G
N
M
S
H
P
R
P
W
L
G
L
D
H
F
N
-------------------
13
PsiBlast_PDB
68.11
100%
-90
- C4 -
-
1NBF
-
UBP7_HUMAN
A:
[208-554]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
H
T
G
Y
V
G
L
K
N
Q
G
A
T
C
Y
M
N
S
L
L
Q
T
L
F
F
T
N
Q
L
R
K
A
V
Y
M
M
P
T
E
G
D
D
S
S
K
S
V
P
L
A
L
Q
R
V
F
Y
E
L
Q
H
S
D
K
P
V
G
T
K
K
L
T
K
S
F
G
W
E
T
L
D
S
F
M
Q
H
D
V
Q
E
L
C
R
V
L
L
D
N
V
E
N
K
M
K
G
T
C
V
E
G
T
I
P
K
L
F
R
G
K
M
V
S
Y
I
Q
C
K
E
V
D
Y
R
S
D
R
R
E
D
Y
Y
D
I
Q
L
S
I
K
G
K
K
N
I
F
E
S
F
V
D
Y
V
A
V
E
Q
L
D
G
D
N
K
Y
D
A
G
E
H
G
L
Q
E
A
E
K
G
V
K
F
L
T
L
P
P
V
L
H
L
Q
L
M
R
F
M
Y
D
P
Q
T
D
Q
N
I
K
I
N
D
R
F
E
F
P
E
Q
L
P
L
D
E
F
L
Q
K
T
D
P
K
D
P
A
N
Y
I
L
H
A
V
L
V
H
S
G
D
N
H
G
G
H
Y
V
V
Y
L
N
P
K
G
D
G
K
W
C
K
F
D
D
D
V
V
S
R
C
T
K
E
E
A
I
E
H
N
Y
G
G
H
D
D
D
L
S
V
R
H
C
T
N
A
Y
M
L
V
Y
I
R
E
S
K
L
S
E
V
L
Q
A
V
T
D
H
D
I
P
Q
Q
L
V
E
R
L
Q
E
E
K
R
I
E
A
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
67.51
99%
-96
- C4 -
-
5N9R
2
UBP7_HUMAN
A:
[2-357]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
K
H
T
G
Y
V
G
L
K
N
Q
G
A
T
C
Y
M
N
S
L
L
Q
T
L
F
F
T
N
Q
L
R
K
A
V
Y
M
M
P
T
E
G
D
D
S
S
K
S
V
P
L
A
L
Q
R
V
F
Y
E
L
Q
H
S
D
K
P
V
G
T
K
K
L
T
K
S
F
G
W
E
T
L
D
S
F
M
Q
H
D
V
Q
E
L
C
R
V
L
L
D
N
V
E
N
K
M
K
G
T
C
V
E
G
T
I
P
K
L
F
R
G
K
M
V
S
Y
I
Q
C
K
E
V
D
Y
R
S
D
R
R
E
D
Y
Y
D
I
Q
L
S
I
K
G
K
K
N
I
F
E
S
F
V
D
Y
V
A
V
E
Q
L
D
G
D
N
K
Y
D
A
G
E
H
G
L
Q
E
A
E
K
G
V
K
F
L
T
L
P
P
V
L
H
L
Q
L
M
R
F
M
Y
D
P
Q
T
D
Q
N
I
K
I
N
D
R
F
E
F
P
E
Q
L
P
L
D
E
F
L
Q
K
T
D
P
K
D
P
A
N
Y
I
L
H
A
V
L
V
H
S
G
D
N
H
G
G
H
Y
V
V
Y
L
N
P
K
G
D
G
K
W
C
K
F
D
D
D
V
V
S
R
C
T
K
E
E
A
I
E
H
N
Y
G
G
H
D
D
-
L
S
V
R
H
C
T
N
A
Y
M
L
V
Y
I
R
E
S
K
L
S
E
V
L
Q
A
V
T
D
H
D
I
P
Q
Q
L
V
E
R
L
Q
E
E
K
R
I
E
A
Q
K
R
K
E
R
Q
E
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
67.37
99%
-99
- C4 -
-
5KYC
3
?
B:
[7-346]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
T
G
Y
V
G
L
K
N
Q
G
A
T
C
Y
M
N
S
L
L
Q
T
L
F
F
T
N
Q
L
R
K
A
V
Y
M
M
P
T
E
G
D
D
S
S
K
S
V
P
L
A
L
Q
R
V
F
Y
E
L
Q
H
S
D
K
P
V
G
T
K
K
L
T
K
S
F
G
W
E
T
L
D
S
F
M
Q
H
D
V
Q
E
L
C
R
K
L
L
D
N
V
E
N
K
M
K
G
T
C
V
E
G
T
I
P
K
L
F
R
G
K
M
V
S
Y
I
Q
C
K
E
V
D
Y
R
S
D
R
R
E
D
Y
Y
D
I
Q
L
S
I
K
G
K
K
N
I
F
E
S
F
V
D
Y
V
A
V
E
Q
L
D
G
D
N
K
Y
D
A
G
E
H
G
L
Q
E
A
E
K
G
V
K
F
L
T
L
P
P
V
L
H
L
Q
L
M
R
F
M
Y
D
P
Q
T
D
Q
N
I
K
I
N
D
R
F
E
F
P
E
Q
L
P
L
D
E
F
L
Q
K
T
D
P
K
D
P
A
N
Y
I
L
H
A
V
L
V
H
S
G
D
N
H
G
G
H
Y
V
V
Y
L
N
P
K
G
D
G
K
W
C
K
F
D
D
D
V
V
S
R
C
T
K
E
E
A
I
E
H
N
Y
G
G
H
D
D
D
L
S
V
R
H
C
T
N
A
Y
M
L
V
Y
I
R
E
S
K
L
S
E
V
L
Q
A
V
T
D
H
D
I
P
Q
Q
L
V
E
R
L
Q
E
E
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
67.24
100%
-95
- C4 -
-
4M5W
-
UBP7_HUMAN
A:
[3-349]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
H
T
G
Y
V
G
L
K
N
Q
G
A
T
C
Y
M
N
S
L
L
Q
T
L
F
F
T
N
Q
L
R
K
A
V
Y
M
M
P
T
E
G
D
D
S
S
K
S
V
P
L
A
L
Q
R
V
F
Y
E
L
Q
H
S
D
K
P
V
G
T
K
K
L
T
K
S
F
G
W
E
T
L
D
S
F
M
Q
H
D
V
Q
E
L
C
R
V
L
L
D
N
V
E
N
K
M
K
G
T
C
V
E
G
T
I
P
K
L
F
R
G
K
M
V
S
Y
I
Q
C
K
E
V
D
Y
R
S
D
R
R
E
D
Y
Y
D
I
Q
L
S
I
K
G
K
K
N
I
F
E
S
F
V
D
Y
V
A
V
E
Q
L
D
G
D
N
K
Y
D
A
G
E
H
G
L
Q
E
A
E
K
G
V
K
F
L
T
L
P
P
V
L
H
L
Q
L
M
R
F
M
Y
D
P
Q
T
D
Q
N
I
K
I
N
D
R
F
E
F
P
E
Q
L
P
L
D
E
F
L
Q
K
T
D
P
K
D
P
A
N
Y
I
L
H
A
V
L
V
H
S
G
D
N
H
G
G
H
Y
V
V
Y
L
N
P
K
G
D
G
K
W
C
K
F
D
D
D
V
V
S
R
C
T
K
E
E
A
I
E
H
N
Y
G
G
H
D
D
D
----
H
C
T
N
A
Y
M
L
V
Y
I
R
E
S
K
L
S
E
V
L
Q
A
V
T
D
H
D
I
P
Q
Q
L
V
E
R
L
Q
E
E
K
R
I
E
A
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
67.20
100%
-105
- C4 -
-
5NGE
1
UBP7_HUMAN
A:
[7-351]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
V
G
L
K
N
Q
G
A
T
C
Y
M
N
S
L
L
Q
T
L
F
F
T
N
Q
L
R
K
A
V
Y
M
M
P
T
E
G
D
D
S
S
K
S
V
P
L
A
L
Q
R
V
F
Y
E
L
Q
H
S
D
K
P
V
G
T
K
K
L
T
K
S
F
G
W
E
T
L
D
S
F
M
Q
H
D
V
Q
E
L
C
R
V
L
L
D
N
V
E
N
K
M
K
G
T
C
V
E
G
T
I
P
K
L
F
R
G
K
M
V
S
Y
I
Q
C
K
E
V
D
Y
R
S
D
R
R
E
D
Y
Y
D
I
Q
L
S
I
K
G
K
K
N
I
F
E
S
F
V
D
Y
V
A
V
E
Q
L
D
G
D
N
K
Y
D
A
G
E
H
G
L
Q
E
A
E
K
G
V
K
F
L
T
L
P
P
V
L
H
L
Q
L
M
R
F
M
Y
D
P
Q
T
D
Q
N
I
K
I
N
D
R
F
E
F
P
E
Q
L
P
L
D
E
F
L
Q
K
T
D
P
K
D
P
A
N
Y
I
L
H
A
V
L
V
H
S
G
D
N
H
G
G
H
Y
V
V
Y
L
N
P
K
G
D
G
K
W
C
K
F
D
D
D
V
V
S
R
C
T
K
E
E
A
I
E
H
N
Y
G
G
--------
H
C
T
N
A
Y
M
L
V
Y
I
R
E
S
K
L
S
E
V
L
Q
A
V
T
D
H
D
I
P
Q
Q
L
V
E
R
L
Q
E
E
K
R
I
E
A
Q
K
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
67.03
100%
-93
- C4 -
-
5N9T
4
?
A:
[1-356]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
K
H
T
G
Y
V
G
L
K
N
Q
G
A
T
C
Y
M
N
S
L
L
Q
T
L
F
F
T
N
Q
L
R
K
A
V
Y
M
M
P
T
E
G
D
D
S
S
K
S
V
P
L
A
L
Q
R
V
F
Y
E
L
Q
H
S
D
K
P
V
G
T
K
K
L
T
K
S
F
G
W
E
T
L
D
S
F
M
Q
H
D
V
Q
E
L
C
R
V
L
L
D
N
V
E
N
K
M
K
G
T
C
V
E
G
T
I
P
K
L
F
R
G
K
M
V
S
Y
I
Q
C
K
E
V
D
Y
R
S
D
R
R
E
D
Y
Y
D
I
Q
L
S
I
K
G
K
K
N
I
F
E
S
F
V
D
Y
V
A
V
E
Q
L
D
G
D
N
K
Y
D
A
G
E
H
G
L
Q
E
A
E
K
G
V
K
F
L
T
L
P
P
V
L
H
L
Q
L
M
R
F
M
Y
D
P
Q
T
D
Q
N
I
K
I
N
D
R
F
E
F
P
E
Q
L
P
L
D
E
F
L
Q
K
T
D
P
K
D
P
A
N
Y
I
L
H
A
V
L
V
H
S
G
D
N
H
G
G
H
Y
V
V
Y
L
N
P
K
G
D
G
K
W
C
K
F
D
D
D
V
V
S
R
C
T
K
E
E
A
I
E
H
N
Y
G
G
H
D
D
D
L
S
V
R
H
C
T
N
A
Y
M
L
V
Y
I
R
E
S
K
L
S
E
V
L
Q
A
V
T
D
H
D
I
P
Q
Q
L
V
E
R
L
Q
E
E
K
R
I
E
A
Q
K
R
K
E
R
Q
E
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
67.03
100%
-99
- C4 -
-
4M5X
-
UBP7_HUMAN
A:
[4-349]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
T
G
Y
V
G
L
K
N
Q
G
A
T
C
Y
M
N
S
L
L
Q
T
L
F
F
T
N
Q
L
R
K
A
V
Y
M
M
P
T
E
G
D
D
S
S
K
S
V
P
L
A
L
Q
R
V
F
Y
E
L
Q
H
S
D
K
P
V
G
T
K
K
L
T
K
S
F
G
W
E
T
L
D
S
F
M
Q
H
D
V
Q
E
L
C
R
V
L
L
D
N
V
E
N
K
M
K
G
T
C
V
E
G
T
I
P
K
L
F
R
G
K
M
V
S
Y
I
Q
C
K
E
V
D
Y
R
S
D
R
R
E
D
Y
Y
D
I
Q
L
S
I
K
G
K
K
N
I
F
E
S
F
V
D
Y
V
A
V
E
Q
L
D
G
D
N
K
Y
D
A
G
E
H
G
L
Q
E
A
E
K
G
V
K
F
L
T
L
P
P
V
L
H
L
Q
L
M
R
F
M
Y
D
P
Q
T
D
Q
N
I
K
I
N
D
R
F
E
F
P
E
Q
L
P
L
D
E
F
L
Q
K
T
D
P
K
D
P
A
N
Y
I
L
H
A
V
L
V
H
S
G
D
N
H
G
G
H
Y
V
V
Y
L
N
P
K
G
D
G
K
W
C
K
F
D
D
D
V
V
S
R
C
T
K
E
E
A
I
E
H
N
Y
G
G
H
-------
H
C
T
N
A
Y
M
L
V
Y
I
R
E
S
K
L
S
E
V
L
Q
A
V
T
D
H
D
I
P
Q
Q
L
V
E
R
L
Q
E
E
K
R
I
E
A
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
66.93
99%
-93
- C4 -
-
5N9T
4
?
A:
[1-356]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
K
H
T
G
Y
V
G
L
K
N
Q
G
A
T
C
Y
M
N
S
L
L
Q
T
L
F
F
T
N
Q
L
R
K
A
V
Y
M
M
P
T
E
G
D
D
S
S
K
S
V
P
L
A
L
Q
R
V
F
Y
E
L
Q
H
S
D
K
P
V
G
T
K
K
L
T
K
S
F
G
W
E
T
L
D
S
F
M
Q
H
D
V
Q
E
L
C
R
V
L
L
D
N
V
E
N
K
M
K
G
T
C
V
E
G
T
I
P
K
L
F
R
G
K
M
V
S
Y
I
Q
C
K
E
V
D
Y
R
S
D
R
R
E
D
Y
Y
D
I
Q
L
S
I
K
G
K
K
N
I
F
E
S
F
V
D
Y
V
A
V
E
Q
L
D
G
D
N
K
Y
D
A
G
E
H
G
L
Q
E
A
E
K
G
V
K
F
L
T
L
P
P
V
L
H
L
Q
L
M
R
F
M
Y
D
P
Q
T
D
Q
N
I
K
I
N
D
R
F
E
F
P
E
Q
L
P
L
D
E
F
L
Q
K
T
D
P
K
D
P
A
N
Y
I
L
H
A
V
L
V
H
S
G
D
N
H
G
G
H
Y
V
V
Y
L
N
P
K
G
D
G
K
W
C
K
F
D
D
D
V
V
S
R
C
T
K
E
E
A
I
E
H
N
Y
G
G
H
D
D
D
L
S
V
R
H
C
T
N
A
Y
M
L
V
Y
I
R
E
S
K
L
S
E
V
L
Q
A
V
T
D
H
D
I
P
Q
Q
L
V
E
R
L
Q
E
E
K
R
I
E
A
Q
K
R
K
E
R
Q
E
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
66.48
100%
-114
- C4 -
-
5VSB
2
UBP7_HUMAN
A:
[4-347]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
Y
V
G
L
K
N
Q
G
A
T
C
Y
M
N
S
L
L
Q
T
L
F
F
T
N
Q
L
R
K
A
V
Y
M
M
P
T
E
G
D
D
S
S
K
S
V
P
L
A
L
Q
R
V
F
Y
E
L
Q
H
S
D
K
P
V
G
T
K
K
L
T
K
S
F
G
W
E
T
L
D
S
F
M
Q
H
D
V
Q
E
L
C
R
V
L
L
D
N
V
E
N
K
M
K
G
T
C
V
E
G
T
I
P
K
L
F
R
G
K
M
V
S
Y
I
Q
C
K
E
V
D
Y
R
S
D
R
R
E
D
Y
Y
D
I
Q
L
S
I
K
G
K
K
N
I
F
E
S
F
V
D
Y
V
A
V
E
Q
L
D
G
D
N
K
Y
D
A
G
E
H
G
L
Q
E
A
E
K
G
V
K
F
L
T
L
P
P
V
L
H
L
Q
L
M
R
F
M
Y
D
P
Q
T
D
Q
N
I
K
I
N
D
R
F
E
F
P
E
Q
L
P
L
D
E
F
L
Q
K
T
D
P
K
D
P
A
N
Y
I
L
H
A
V
L
V
H
S
G
D
N
H
G
G
H
Y
V
V
Y
L
N
P
K
G
D
G
K
W
C
K
F
D
D
D
V
V
S
R
C
T
K
E
E
A
I
E
H
N
Y
G
G
---------
C
T
N
A
Y
M
L
V
Y
I
R
E
S
K
L
S
E
V
L
Q
A
V
T
D
H
D
I
P
Q
Q
L
V
E
R
L
Q
E
E
K
R
I
E
A
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
65.85
100%
-99
- C4 -
-
5VS6
1
UBP7_HUMAN
A:
[1-347]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
H
T
G
Y
V
G
L
K
N
Q
G
A
T
C
Y
M
N
S
L
L
Q
T
L
F
F
T
N
Q
L
R
K
A
V
Y
M
M
P
T
E
G
D
D
S
S
K
S
V
P
L
A
L
Q
R
V
F
Y
E
L
Q
H
S
D
K
P
V
G
T
K
K
L
T
K
S
F
G
W
E
T
L
D
S
F
M
Q
H
D
V
Q
E
L
C
R
V
L
L
D
N
V
E
N
K
M
K
G
T
C
V
E
G
T
I
P
K
L
F
R
G
K
M
V
S
Y
I
Q
C
K
E
V
D
Y
R
S
D
R
R
E
D
Y
Y
D
I
Q
L
S
I
K
G
K
K
N
I
F
E
S
F
V
D
Y
V
A
V
E
Q
L
D
G
D
N
K
Y
D
A
G
E
H
G
L
Q
E
A
E
K
G
V
K
F
L
T
L
P
P
V
L
H
L
Q
L
M
R
F
M
Y
D
P
Q
T
D
Q
N
I
K
I
N
D
R
F
E
F
P
E
Q
L
P
L
D
E
F
L
Q
K
T
D
P
K
D
P
A
N
Y
I
L
H
A
V
L
V
H
S
G
D
N
H
G
G
H
Y
V
V
Y
L
N
P
K
G
D
G
K
W
C
K
F
D
D
D
V
V
S
R
C
T
K
E
E
A
I
E
H
N
Y
G
G
--------
H
C
T
N
A
Y
M
L
V
Y
I
R
E
S
K
L
S
E
V
L
Q
A
V
T
D
H
D
I
P
Q
Q
L
V
E
R
L
Q
E
E
K
R
I
E
A
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
64.14
100%
-105
- C4 -
-
5VSK
1
UBP7_HUMAN
A:
[1-345]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
H
T
G
Y
V
G
L
K
N
Q
G
A
T
C
Y
M
N
S
L
L
Q
T
L
F
F
T
N
Q
L
R
K
A
V
Y
M
M
P
T
E
G
D
D
S
S
K
S
V
P
L
A
L
Q
R
V
F
Y
E
L
Q
H
S
D
K
P
V
G
T
K
K
L
T
K
S
F
G
W
E
T
L
D
S
F
M
Q
H
D
V
Q
E
L
C
R
V
L
L
D
N
V
E
N
K
M
K
G
T
C
V
E
G
T
I
P
K
L
F
R
G
K
M
V
S
Y
I
Q
C
K
E
V
D
Y
R
S
D
R
R
E
D
Y
Y
D
I
Q
L
S
I
K
G
K
K
N
I
F
E
S
F
V
D
Y
V
A
V
E
Q
L
D
G
D
N
K
Y
D
A
G
E
H
G
L
Q
E
A
E
K
G
V
K
F
L
T
L
P
P
V
L
H
L
Q
L
M
R
F
M
-------
N
I
K
I
N
D
R
F
E
F
P
E
Q
L
P
L
D
E
F
L
Q
K
T
D
P
K
D
P
A
N
Y
I
L
H
A
V
L
V
H
S
G
D
N
H
G
G
H
Y
V
V
Y
L
N
P
K
G
D
G
K
W
C
K
F
D
D
D
V
V
S
R
C
T
K
E
E
A
I
E
H
N
Y
G
G
--------
H
C
T
N
A
Y
M
L
V
Y
I
R
E
S
K
L
S
E
V
L
Q
A
V
T
D
H
D
I
P
Q
Q
L
V
E
R
L
Q
E
E
K
R
I
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------