@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NED4L_HUMAN: (2018-10-04 )
MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......--770.........780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930........940.......950.......960.......970...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MATGLGEPVYGLSEDEGE
S
R
I
L
R
V
K
V
VSGID
L
A
K
K
DIFGASD
P
Y
V
K
L
S
L
Y
V
ADENR
E
L
A
L
V
Q
T
K
T
I
K
K
TLNPKWN
E
E
F
Y
F
R
VNPSN
H
R
L
L
F
E
VFDENRL
T
R
D
DFLGQVDVPLSHLPTEDPTMERPY
T
F
K
D
F
LLRPRS
H
K
S
R
V
K
G
F
L
R
L
K
M
A
YMPKNGGQDEENSD
Q
R
D
D
M
E
HG
W
E
V
VDSNDSA
S
Q
H
Q
EELPPPPLPP
G
W
E
E
K
V
D
NLG
R
T
Y
Y
V
NHNNRTTQWHRPSLMDVSSESDN
N
I
R
Q
I
N
Q
E
A
A
H
R
R
F
R
S
RRHISEDLEPEPSEGGDVP
E
P
W
E
T
I
S
E
E
VNIAGDSLGLALPPPPASPGSRT
S
P
Q
E
L
S
E
E
L
S
R
R
L
QITPDSN
G
E
Q
F
S
S
L
I
QRE
P
S
S
R
LRSCS
V
T
D
A
V
A
EQGHLPPPSAPAGRARSSTVTGGEEPTP
S
V
A
Y
V
HTTPGLPSG
W
E
E
RKDAKG
R
T
Y
Y
V
NHNNRTT
T
W
T
R
P
I
M
Q
L
A
EDGASGSATNSNNHLIEPQIRRPRSLSS
P
T
V
T
L
SAPLEGAKD
S
P
V
R
R
A
V
K
D
T
LSNPQSPQPSPYNSPKP
Q
H
K
V
T
Q
SFLPPGW
E
M
R
IAPNG
R
P
F
F
I
DHNTKTTTWEDP
R
L
K
F
P
V
H
MRSKTSLNPNDLGPLPP
G
W
E
E
R
I
H
LDG
R
T
F
Y
I
DHNSKITQWEDPRLQNPAITGPAVP
Y
S
R
E
F
K
Q
K
Y
D
Y
F
R
K
K
LKKPADIP
N
R
F
E
M
K
LHRNN
I
F
E
E
S
Y
R
R
I
M
SVKRPD
V
L
K
A
R
L
W
I
E
FESEKGLDY
G
G
V
A
R
E
W
F
F
L
L
S
K
E
M
FNPYY
G
L
F
E
YSATD
N
Y
T
L
Q
INPNSGLC
N
E
D
H
L
S
Y
F
T
F
I
G
R
V
A
G
L
A
V
F
H
GKLL
D
G
F
F
I
R
P
F
Y
K
M
MLGKQITL
N
D
M
E
S
V
D
S
E
Y
Y
N
S
L
K
W
I
LENDPT--
E
--
L
D
L
M
F
C
IDEENFG
Q
T
Y
Q
V
D
LKPNG
S
E
I
M
V
TNEN
K
R
E
Y
I
D
L
V
I
Q
W
R
F
V
N
R
V
Q
K
Q
M
N
A
F
L
E
G
F
T
E
LL
P
I
D
L
I
K
IFDENE
L
E
L
L
M
CGLGDV
D
V
N
D
W
R
QHSIYKNGYCPNH
P
V
I
Q
W
F
W
K
A
V
L
L
M
D
A
E
K
R
I
R
L
L
Q
F
VTGTSRVP
M
N
G
F
A
E
L
YGSNG
P
Q
L
F
T
IEQWG-SPEKL
P
R
A
H
T
C
F
N
RLDLP
P
Y
E
T
F
E
D
L
R
E
K
L
L
M
A
V
ENAQGFEGVD
40
HHSearch
98.46
99%
-133
- C1 -
-
2ONI
-
NED4L_HUMAN
A:
[15-391]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
Q
G
S
R
E
F
K
Q
K
Y
D
Y
F
R
K
K
L
K
K
P
A
D
I
P
N
R
F
E
M
K
L
H
R
N
N
I
F
E
E
S
Y
R
R
I
M
S
V
K
R
P
D
V
L
K
A
R
L
W
I
E
F
E
-
E
K
G
L
D
Y
G
G
V
A
R
E
W
F
F
L
L
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
S
G
L
C
N
E
D
H
L
S
Y
F
T
F
I
G
R
V
A
G
L
A
V
F
H
G
K
L
L
D
G
F
F
I
R
P
F
Y
K
M
M
L
G
K
Q
I
T
L
N
D
M
E
S
V
D
S
E
Y
Y
N
S
L
K
W
I
L
E
N
D
P
T
--
E
--
L
D
L
M
F
C
I
D
E
E
N
F
G
Q
T
Y
Q
V
D
L
K
P
N
G
S
E
I
M
V
T
N
E
N
K
R
E
Y
I
D
L
V
I
Q
W
R
F
V
N
R
V
Q
K
Q
M
N
A
F
L
E
G
F
T
E
L
L
P
I
D
L
I
K
I
F
D
E
N
E
L
E
L
L
M
C
G
L
G
D
V
D
V
N
D
W
R
Q
H
S
I
Y
K
N
G
Y
C
P
N
H
P
V
I
Q
W
F
W
K
A
V
L
L
M
D
A
E
K
R
I
R
L
L
Q
F
V
T
G
T
S
R
V
P
M
N
G
F
A
E
L
Y
G
S
N
G
P
Q
L
F
T
I
E
Q
W
G
-
S
P
E
K
L
P
R
A
H
T
C
F
N
R
L
D
L
P
P
Y
E
T
F
E
D
L
R
E
K
L
L
M
A
V
E
---------
4
PsiBlast_PDB
97.09
96%
-133
- C1 -
-
2ONI
-
NED4L_HUMAN
A:
[19-391]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
F
K
Q
K
Y
D
Y
F
R
K
K
L
K
K
P
A
D
I
P
N
R
F
E
M
K
L
H
R
N
N
I
F
E
E
S
Y
R
R
I
M
S
V
K
R
P
D
V
L
K
A
R
L
W
I
E
F
E
-
E
K
G
L
D
Y
G
G
V
A
R
E
W
F
F
L
L
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
S
G
L
C
N
E
D
H
L
S
Y
F
T
F
I
G
R
V
A
G
L
A
V
F
H
G
K
L
L
D
G
F
F
I
R
P
F
Y
K
M
M
L
G
K
Q
I
T
L
N
D
M
E
S
V
D
S
E
Y
Y
N
S
L
K
W
I
L
E
N
D
P
T
--
E
--
L
D
L
M
F
C
I
D
E
E
N
F
G
Q
T
Y
Q
V
D
L
K
P
N
G
S
E
I
M
V
T
N
E
N
K
R
E
Y
I
D
L
V
I
Q
W
R
F
V
N
R
V
Q
K
Q
M
N
A
F
L
E
G
F
T
E
L
L
P
I
D
L
I
K
I
F
D
E
N
E
L
E
L
L
M
C
G
L
G
D
V
D
V
N
D
W
R
Q
H
S
I
Y
K
N
G
Y
C
P
N
H
P
V
I
Q
W
F
W
K
A
V
L
L
M
D
A
E
K
R
I
R
L
L
Q
F
V
T
G
T
S
R
V
P
M
N
G
F
A
E
L
Y
G
S
N
G
P
Q
L
F
T
I
E
Q
W
G
-
S
P
E
K
L
P
R
A
H
T
C
F
N
R
L
D
L
P
P
Y
E
T
F
E
D
L
R
E
K
L
L
M
A
V
E
---------
1
PsiBlast_PDB
96.16
100%
-120
- C1 -
-
5HPK
-
?
A:
[574-949]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
F
K
Q
K
Y
D
Y
F
R
K
K
L
K
K
P
A
D
I
P
N
R
F
E
M
K
L
H
R
N
N
I
F
E
E
S
Y
R
R
I
M
S
V
K
R
P
D
V
L
K
A
R
L
W
I
E
F
E
-----
D
Y
G
G
V
A
R
E
W
F
F
L
L
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
S
G
L
C
N
E
D
H
L
S
Y
F
T
F
I
G
R
V
A
G
L
A
V
F
H
G
K
L
L
D
G
F
F
I
R
P
F
Y
K
M
M
L
G
K
Q
I
T
L
N
D
M
E
S
V
D
S
E
Y
Y
N
S
L
K
W
I
L
E
N
D
P
T
--
E
--
L
D
L
M
F
C
I
D
E
E
N
F
G
Q
T
Y
Q
V
D
L
K
P
N
G
S
E
I
M
V
T
N
E
N
K
R
E
Y
I
D
L
V
I
Q
W
R
F
V
N
R
V
Q
K
Q
M
N
A
F
L
E
G
F
T
E
L
L
P
I
D
L
I
K
I
F
D
E
N
E
L
E
L
L
M
C
G
L
G
D
V
D
V
N
D
W
R
Q
H
S
I
Y
K
N
G
Y
C
P
N
H
P
V
I
Q
W
F
W
K
A
V
L
L
M
D
A
E
K
R
I
R
L
L
Q
F
V
T
G
T
S
R
V
P
M
N
G
F
A
E
L
Y
G
S
N
G
P
Q
L
F
T
I
E
Q
W
G
-
S
P
E
K
L
P
R
A
H
T
C
F
N
R
L
D
L
P
P
Y
E
T
F
E
D
L
R
E
K
L
L
M
A
V
E
N
A
Q
------
3
PsiBlast_PDB
96.14
99%
-130
- C1 -
-
3JW0
-
NED4L_HUMAN
C:
[576-950]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
K
Q
K
Y
D
Y
F
R
K
K
L
K
K
P
A
D
I
P
N
R
F
E
M
K
L
H
R
N
N
I
F
E
E
S
Y
R
R
I
M
S
V
K
R
P
D
V
L
K
A
R
L
W
I
E
F
E
S
E
K
G
L
D
Y
G
G
V
A
R
E
W
F
F
L
L
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
S
G
L
C
N
E
D
H
L
S
Y
F
T
F
I
G
R
V
A
G
L
A
V
F
H
G
K
L
L
D
G
F
F
I
R
P
F
Y
K
M
M
L
G
K
Q
I
T
L
N
D
M
E
S
V
D
S
E
Y
Y
N
S
L
K
W
I
L
E
N
D
P
T
--
E
--
L
D
L
M
F
C
I
D
E
E
N
F
G
Q
T
Y
Q
V
D
L
K
P
N
G
S
E
I
M
V
T
N
E
N
K
R
E
Y
I
D
L
V
I
Q
W
R
F
V
N
R
V
Q
K
Q
M
N
A
F
L
E
G
F
T
E
L
L
P
I
D
L
I
K
I
F
D
E
N
E
L
E
L
L
M
C
G
L
G
D
V
D
V
N
D
W
R
Q
H
S
I
Y
K
N
G
Y
C
P
N
H
P
V
I
Q
W
F
W
K
A
V
L
L
M
D
A
E
K
R
I
R
L
L
Q
F
V
T
G
T
S
R
V
P
M
N
G
F
A
E
L
Y
G
S
N
G
P
Q
L
F
T
I
E
Q
W
G
-
S
P
E
K
L
P
R
A
H
T
S
F
N
R
L
D
L
P
P
Y
E
T
F
E
D
L
R
E
K
L
L
M
A
V
E
N
A
Q
G
-----
2
PsiBlast_PDB
95.39
99%
-124
- C1 -
-
3JVZ
-
?
C:
[576-950]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
K
Q
K
Y
D
Y
F
R
K
K
L
K
K
P
A
D
I
P
N
R
F
E
M
K
L
H
R
N
N
I
F
E
E
S
Y
R
R
I
M
S
V
K
R
P
D
V
L
K
A
R
L
W
I
E
F
E
S
E
K
G
L
D
Y
G
G
V
A
R
E
W
F
F
L
L
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
S
G
L
C
N
E
D
H
L
S
Y
F
T
F
I
G
R
V
A
G
L
A
V
F
H
G
K
L
L
D
G
F
F
I
R
P
F
Y
K
M
M
L
G
K
Q
I
T
L
N
D
M
E
S
V
D
S
E
Y
Y
N
S
L
K
W
I
L
E
N
D
P
T
--
E
--
L
D
L
M
F
C
I
D
E
E
N
F
G
Q
T
Y
Q
V
D
L
K
P
N
G
S
E
I
M
V
T
N
E
N
K
R
E
Y
I
D
L
V
I
Q
W
R
F
V
N
R
V
Q
K
Q
M
N
A
F
L
E
G
F
T
E
L
L
P
I
D
L
I
K
I
F
D
E
N
E
L
E
L
L
M
C
G
L
G
D
V
D
V
N
D
W
R
Q
H
S
I
Y
K
N
G
Y
C
P
N
H
P
V
I
Q
W
F
W
K
A
V
L
L
M
D
A
E
K
R
I
R
L
L
Q
F
V
T
G
T
S
R
V
P
M
N
G
F
A
E
L
Y
G
S
N
G
P
Q
L
F
T
I
E
Q
W
G
-
S
P
E
K
L
P
R
A
H
T
A
F
N
R
L
D
L
P
P
Y
E
T
F
E
D
L
R
E
K
L
L
M
A
V
E
N
A
Q
G
-----
41
HHSearch
93.23
83%
-132
- C1 -
-
5C91
1
A:
[2-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
K
R
K
Y
E
F
F
R
R
K
L
K
K
Q
N
D
I
P
N
K
F
E
M
K
L
R
R
A
T
V
L
E
D
S
Y
R
R
I
M
G
V
K
R
A
D
F
L
K
A
R
L
W
I
E
F
D
G
E
K
G
L
D
Y
G
G
V
A
R
E
W
F
F
L
I
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
S
G
L
C
N
E
D
H
L
S
Y
F
K
F
I
G
R
V
A
G
M
A
V
Y
H
G
K
L
L
D
G
F
F
I
R
P
F
Y
K
M
M
L
H
K
P
I
T
L
H
D
M
E
S
V
D
S
E
Y
Y
N
S
L
R
W
I
L
E
N
D
P
T
--
E
--
L
D
L
R
F
I
I
D
E
E
L
F
G
Q
T
H
Q
H
E
L
K
N
G
G
S
E
I
V
V
T
N
K
N
K
K
E
Y
I
Y
L
V
I
Q
W
R
F
V
N
R
I
Q
K
Q
M
A
A
F
K
E
G
F
F
E
L
I
P
Q
D
L
I
K
I
F
D
E
N
E
L
E
L
L
M
C
G
L
G
D
V
D
V
N
D
W
R
E
H
T
K
Y
K
N
G
Y
S
A
N
H
Q
V
I
Q
W
F
W
K
A
V
L
M
M
D
S
E
K
R
I
R
L
L
Q
F
V
T
G
T
S
R
V
P
M
N
G
F
A
E
L
Y
G
S
N
G
P
Q
S
F
T
V
E
Q
W
G
-
T
P
E
K
L
P
R
A
H
T
C
F
N
R
L
D
L
P
P
Y
E
S
F
E
E
L
W
D
K
L
Q
M
A
I
E
N
T
-------
8
PsiBlast_PDB
93.02
82%
-131
- C1 -
-
5C91
1
A:
[1-375]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
D
Y
K
R
K
Y
E
F
F
R
R
K
L
K
K
Q
N
D
I
P
N
K
F
E
M
K
L
R
R
A
T
V
L
E
D
S
Y
R
R
I
M
G
V
K
R
A
D
F
L
K
A
R
L
W
I
E
F
D
G
E
K
G
L
D
Y
G
G
V
A
R
E
W
F
F
L
I
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
S
G
L
C
N
E
D
H
L
S
Y
F
K
F
I
G
R
V
A
G
M
A
V
Y
H
G
K
L
L
D
G
F
F
I
R
P
F
Y
K
M
M
L
H
K
P
I
T
L
H
D
M
E
S
V
D
S
E
Y
Y
N
S
L
R
W
I
L
E
N
D
P
T
--
E
--
L
D
L
R
F
I
I
D
E
E
L
F
G
Q
T
H
Q
H
E
L
K
N
G
G
S
E
I
V
V
T
N
K
N
K
K
E
Y
I
Y
L
V
I
Q
W
R
F
V
N
R
I
Q
K
Q
M
A
A
F
K
E
G
F
F
E
L
I
P
Q
D
L
I
K
I
F
D
E
N
E
L
E
L
L
M
C
G
L
G
D
V
D
V
N
D
W
R
E
H
T
K
Y
K
N
G
Y
S
A
N
H
Q
V
I
Q
W
F
W
K
A
V
L
M
M
D
S
E
K
R
I
R
L
L
Q
F
V
T
G
T
S
R
V
P
M
N
G
F
A
E
L
Y
G
S
N
G
P
Q
S
F
T
V
E
Q
W
G
-
T
P
E
K
L
P
R
A
H
T
C
F
N
R
L
D
L
P
P
Y
E
S
F
E
E
L
W
D
K
L
Q
M
A
I
E
N
T
-------
7
PsiBlast_PDB
92.62
82%
-126
- C- -
-
5C7J
-
NEDD4_HUMAN (first)
A:
[520-895]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
K
R
K
Y
E
F
F
R
R
K
L
K
K
Q
N
D
I
P
N
K
F
E
M
K
L
R
R
A
T
V
L
E
D
S
Y
R
R
I
M
G
V
K
R
A
D
F
L
K
A
R
L
W
I
E
F
D
G
E
K
G
L
D
Y
G
G
V
A
R
E
W
F
F
L
I
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
S
G
L
C
N
E
D
H
L
S
Y
F
K
F
I
G
R
V
A
G
M
A
V
Y
H
G
K
L
L
D
G
F
F
I
R
P
F
Y
K
M
M
L
H
K
P
I
T
L
H
D
M
E
S
V
D
S
E
Y
Y
N
S
L
R
W
I
L
E
N
D
P
T
--
E
--
L
D
L
R
F
I
I
D
E
E
L
F
G
Q
T
H
Q
H
E
L
K
N
G
G
S
E
I
V
V
T
N
K
N
K
K
E
Y
I
Y
L
V
I
Q
W
R
F
V
N
R
I
Q
K
Q
M
A
A
F
K
E
G
F
F
E
L
I
P
Q
D
L
I
K
I
F
D
E
N
E
L
E
L
L
M
C
G
L
G
D
V
D
V
N
D
W
R
E
H
T
K
Y
K
N
G
Y
S
A
N
H
Q
V
I
Q
W
F
W
K
A
V
L
M
M
D
S
E
K
R
I
R
L
L
Q
F
V
T
G
T
S
R
V
P
M
N
G
F
A
E
L
Y
G
---
P
Q
S
F
T
V
E
Q
W
G
-
T
P
E
K
L
P
R
A
H
T
C
F
N
R
L
D
L
P
P
Y
E
S
F
E
E
L
W
D
K
L
Q
M
A
I
E
N
T
Q
G
-----
5
PsiBlast_PDB
91.72
82%
-125
- C1 -
-
2XBB
-
NEDD4_HUMAN
A:
[6-380]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
K
R
K
Y
E
F
F
R
R
K
L
K
K
Q
N
D
I
P
N
K
F
E
M
K
L
R
R
A
T
V
L
E
D
S
Y
R
R
I
M
G
V
K
R
A
D
F
L
K
A
R
L
W
I
E
F
D
G
E
K
G
L
D
Y
G
G
V
A
R
E
W
F
F
L
I
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
S
G
L
C
N
E
D
H
L
S
Y
F
K
F
I
G
R
V
A
G
M
A
V
Y
H
G
K
L
L
D
G
F
F
I
R
P
F
Y
K
M
M
L
H
K
P
I
T
L
H
D
M
E
S
V
D
S
E
Y
Y
N
S
L
R
W
I
L
E
N
D
P
T
--
E
--
L
D
L
R
F
I
I
D
E
E
L
F
G
Q
T
H
Q
H
E
L
K
N
G
G
S
E
I
V
V
T
N
K
N
K
K
E
Y
I
Y
L
V
I
Q
W
R
F
V
N
R
I
Q
K
Q
M
A
A
F
K
E
G
F
F
E
L
I
P
Q
D
L
I
K
I
F
D
E
N
E
L
E
L
L
M
C
G
L
G
D
V
D
V
N
D
W
R
E
H
T
K
Y
K
N
G
Y
S
A
N
H
Q
V
I
Q
W
F
W
K
A
V
L
M
M
D
S
E
K
R
I
R
L
L
Q
F
V
T
G
T
S
R
V
P
M
N
G
F
A
E
L
Y
G
S
N
G
P
Q
S
F
T
V
E
Q
W
G
-
T
P
E
K
L
P
R
A
H
T
C
F
N
R
L
D
L
P
P
Y
E
S
F
E
E
L
W
D
K
L
Q
M
A
I
E
N
T
Q
------
6
PsiBlast_PDB
91.07
82%
-127
- C1 -
-
2XBF
4
A:
[5-379]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
D
Y
K
R
K
Y
E
F
F
R
R
K
L
K
K
Q
N
D
I
P
N
K
F
E
M
K
L
R
R
A
T
V
L
E
D
S
Y
R
R
I
M
G
V
K
R
A
D
F
L
K
A
R
L
W
I
E
F
D
G
E
K
G
L
D
Y
G
G
V
A
R
E
W
F
F
L
I
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
S
G
L
C
N
E
D
H
L
S
Y
F
K
F
I
G
R
V
A
G
M
A
V
Y
H
G
K
L
L
D
G
F
F
I
R
P
F
Y
K
M
M
L
H
K
P
I
T
L
H
D
M
E
S
V
D
S
E
Y
Y
N
S
L
R
W
I
L
E
N
D
P
T
--
E
--
L
D
L
R
F
I
I
D
E
E
L
F
G
Q
T
H
Q
H
E
L
K
N
G
G
S
E
I
V
V
T
N
K
N
K
K
E
Y
I
Y
L
V
I
Q
W
R
F
V
N
R
I
Q
K
Q
M
A
A
F
K
E
G
F
F
E
L
I
P
Q
D
L
I
K
I
F
D
E
N
E
L
E
L
L
M
C
G
L
G
D
V
D
V
N
D
W
R
E
H
T
K
Y
K
N
G
Y
S
A
N
H
Q
V
I
Q
W
F
W
K
A
V
L
M
M
D
S
E
K
R
I
R
L
L
Q
F
V
T
G
T
S
R
V
P
M
N
G
F
A
E
L
Y
G
S
N
G
P
Q
S
F
T
V
E
Q
W
G
-
T
P
E
K
L
P
R
A
H
T
C
F
N
R
L
D
L
P
P
Y
E
S
F
E
E
L
W
D
K
L
Q
M
A
I
E
N
T
-------
18
PsiBlast_PDB
79.17
53%
-135
- C1 -
-
3TUG
-
A:
[20-392]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
D
F
K
A
K
V
Q
Y
F
R
F
W
C
Q
Q
L
A
-
M
P
Q
H
I
K
I
T
V
T
R
K
T
L
F
E
D
S
F
Q
Q
I
M
S
F
S
-
P
Q
D
L
R
R
R
L
W
V
I
F
P
G
E
E
G
L
D
Y
G
G
V
A
R
E
W
F
F
L
L
S
H
E
V
S
N
P
M
Y
C
L
F
E
Y
A
----
Y
C
L
Q
I
N
P
A
S
Y
I
-
N
P
D
H
L
K
Y
F
R
F
I
G
R
F
I
A
M
A
L
F
H
G
K
F
I
D
T
G
F
S
L
P
F
Y
K
R
I
L
N
K
P
V
G
L
K
D
L
E
S
I
D
P
E
F
Y
N
S
L
I
W
V
K
E
N
N
----------
Y
F
S
---------------------------
K
E
E
Y
I
R
M
V
A
E
W
R
L
S
R
G
V
E
E
Q
T
Q
A
F
F
E
G
F
N
E
I
L
P
Q
Q
Y
L
Q
Y
F
D
A
K
E
L
E
V
L
L
C
G
M
Q
E
I
D
L
N
D
W
Q
R
H
A
I
Y
R
R
-
Y
A
R
T
S
K
Q
I
M
W
F
W
Q
F
V
K
E
I
D
N
E
K
R
M
R
L
L
Q
F
V
T
G
T
C
R
L
P
V
G
G
F
A
D
L
M
G
S
N
G
P
Q
K
F
C
I
E
K
V
G
-
K
E
N
W
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
K
E
K
L
L
F
A
I
E
E
T
-------
48
HHSearch
77.83
54%
-61
- C1 -
-
1ZVD
-
SMUF2_HUMAN
A:
[2-373]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
L
V
Q
K
L
K
I
L
R
Q
E
L
S
Q
Q
Q
P
Q
A
G
H
C
R
I
E
V
S
R
E
E
I
F
E
E
S
Y
R
Q
V
M
K
M
-
R
P
K
D
L
W
K
R
L
M
I
K
F
R
G
E
E
G
L
D
Y
G
G
V
A
R
E
W
L
Y
L
L
S
H
E
M
L
N
P
Y
Y
G
L
F
Q
Y
S
R
D
D
I
Y
T
L
Q
I
N
P
D
S
A
V
-
N
P
E
H
L
S
Y
F
H
F
V
G
R
I
M
G
M
A
V
F
H
G
H
Y
I
D
G
G
F
T
L
P
F
Y
K
Q
L
L
G
K
S
I
T
L
D
D
M
E
L
V
D
P
D
L
H
N
S
L
V
W
I
L
E
N
D
I
T
G-
V
--
L
D
H
T
F
C
V
E
H
N
A
Y
G
E
I
I
Q
H
E
L
K
P
N
G
K
S
I
P
V
N
E
E
N
K
K
E
Y
V
R
L
Y
V
N
W
R
F
L
R
G
I
E
A
Q
F
L
A
L
Q
K
G
F
N
E
V
I
P
Q
H
L
L
K
T
F
D
E
K
E
L
E
L
I
I
C
G
L
G
K
I
D
V
N
D
W
K
V
N
T
R
L
K
H
-
C
T
P
D
S
N
I
V
K
W
F
W
K
A
V
E
F
F
D
E
E
R
R
A
R
L
L
Q
F
V
T
G
S
S
R
V
P
L
Q
G
F
K
A
L
Q
G
A
A
G
P
R
L
F
T
I
H
Q
I
D
A
C
T
N
N
L
P
K
A
H
T
C
F
N
R
I
D
I
P
P
Y
E
S
Y
E
K
L
Y
E
K
L
L
T
A
I
E
E
--------
47
HHSearch
77.76
52%
-55
- C1 -
-
5HPS
-
WWP1_HUMAN
A:
[541-916]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
Y
E
R
G
F
R
W
K
L
A
H
F
R
Y
L
C
Q
S
-
N
A
L
P
S
H
V
K
I
N
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
A
L
-
K
P
Y
D
L
R
R
R
L
Y
V
I
F
R
G
E
E
---
Y
G
G
L
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
S
T
I
-
N
P
D
H
L
S
Y
F
C
F
I
G
R
F
I
A
M
A
L
F
H
G
K
F
I
D
T
G
F
S
L
P
F
Y
K
R
M
L
S
K
K
L
T
I
K
D
L
E
S
I
D
T
E
F
Y
N
S
L
I
W
I
R
D
N
N
I
E
--
E
CG
L
E
M
Y
F
S
V
D
M
E
I
L
G
K
V
T
S
H
D
L
K
L
G
G
S
N
I
L
V
T
E
E
N
K
D
E
Y
I
G
L
M
T
E
W
R
F
S
R
G
V
Q
E
Q
T
K
A
F
L
D
G
F
N
E
V
V
P
L
Q
W
L
Q
Y
F
D
E
K
E
L
E
V
M
L
C
G
M
Q
E
V
D
L
A
D
W
Q
R
N
T
V
Y
R
H
-
Y
T
R
N
S
K
Q
I
I
W
F
W
Q
F
V
K
E
T
D
N
E
V
R
M
R
L
L
Q
F
V
T
G
T
C
R
L
P
L
G
G
F
A
E
L
M
G
S
N
G
P
Q
K
F
C
I
E
K
V
G
-
K
D
T
W
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
K
E
K
L
L
F
A
I
E
E
T
-------
20
PsiBlast_PDB
77.35
51%
-55
- C1 -
-
5HPS
-
WWP1_HUMAN
A:
[541-917]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
Y
E
R
G
F
R
W
K
L
A
H
F
R
Y
L
C
Q
S
N
A
-
L
P
S
H
V
K
I
N
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
A
L
K
-
P
Y
D
L
R
R
R
L
Y
V
I
F
R
G
E
E
---
Y
G
G
L
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
S
T
I
-
N
P
D
H
L
S
Y
F
C
F
I
G
R
F
I
A
M
A
L
F
H
G
K
F
I
D
T
G
F
S
L
P
F
Y
K
R
M
L
S
K
K
L
T
I
K
D
L
E
S
I
D
T
E
F
Y
N
S
L
I
W
I
R
D
N
N
I
E
--
E
CG
L
E
M
Y
F
S
V
D
M
E
I
L
G
K
V
T
S
H
D
L
K
L
G
G
S
N
I
L
V
T
E
E
N
K
D
E
Y
I
G
L
M
T
E
W
R
F
S
R
G
V
Q
E
Q
T
K
A
F
L
D
G
F
N
E
V
V
P
L
Q
W
L
Q
Y
F
D
E
K
E
L
E
V
M
L
C
G
M
Q
E
V
D
L
A
D
W
Q
R
N
T
V
Y
R
H
-
Y
T
R
N
S
K
Q
I
I
W
F
W
Q
F
V
K
E
T
D
N
E
V
R
M
R
L
L
Q
F
V
T
G
T
C
R
L
P
L
G
G
F
A
E
L
M
G
S
N
G
P
Q
K
F
C
I
E
K
V
G
-
K
D
T
W
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
K
E
K
L
L
F
A
I
E
E
T
E
------
10
PsiBlast_PDB
76.67
81%
-
- C1 -
-
4BE8
-
A:
[519-894]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
D
Y
K
R
K
Y
E
F
F
R
R
K
L
K
K
Q
N
D
I
P
N
K
F
E
M
K
L
R
R
A
T
V
L
E
D
S
Y
R
R
I
M
G
V
K
R
A
D
F
L
K
A
R
L
W
I
E
F
D
G
E
K
G
L
D
Y
G
G
V
A
R
E
W
F
F
L
I
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
S
G
I
-
N
P
D
H
L
S
Y
F
K
F
I
G
R
V
A
G
M
A
V
Y
H
G
K
L
L
D
G
F
F
I
R
P
F
Y
K
M
M
L
H
K
P
I
T
L
H
D
M
E
S
V
D
S
E
Y
Y
N
S
L
R
W
I
L
E
N
D
P
T
--
E
--
L
D
L
R
F
I
I
D
E
E
L
F
G
Q
T
H
Q
H
E
L
K
N
G
G
S
E
I
V
V
T
N
K
N
K
K
E
Y
I
Y
L
V
I
Q
W
R
F
V
N
R
I
Q
K
Q
M
A
A
F
K
E
G
F
F
E
L
I
P
Q
D
L
I
K
I
F
D
E
N
E
L
E
L
L
M
S
G
L
G
D
V
D
V
N
D
W
R
E
H
T
K
Y
K
N
G
Y
S
A
N
H
Q
V
I
Q
W
F
W
K
A
V
L
M
M
D
S
E
K
R
I
R
L
L
Q
F
V
T
G
T
S
R
V
P
M
N
G
F
A
E
L
Y
G
S
N
G
P
Q
S
F
T
V
E
Q
W
G
-
T
P
E
K
L
P
R
A
H
T
C
F
N
R
L
D
L
P
P
Y
E
S
F
E
E
L
W
D
K
L
Q
M
F
I
E
N
T
Q
G
-----
15
PsiBlast_PDB
75.55
47%
-40
- C1 -
-
5TJ7
-
WWP2_HUMAN
A:
[3-447]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
E
K
R
T
D
P
R
G
R
F
Y
Y
V
D
H
N
T
R
T
T
T
W
Q
R
P
T
A
E
Y
V
R
N
Y
E
Q
W
Q
S
Q
R
N
Q
L
Q
G
A
M
Q
-------
H
F
S
Q
R
F
L
Y
Q
S
--------------
S
---------
Y
D
R
S
F
R
W
K
Y
H
Q
F
R
F
L
C
H
S
N
A
-
L
P
S
H
V
K
I
S
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
N
M
K
-
P
Y
D
L
R
R
R
L
Y
I
I
M
R
G
E
E
G
L
D
Y
G
G
I
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
S
S
I
-
N
P
D
H
L
T
Y
F
R
F
I
G
R
F
I
A
M
A
L
Y
H
G
K
F
I
D
T
G
F
T
L
P
F
Y
K
R
M
L
N
K
R
P
T
L
K
D
L
E
S
I
D
P
E
F
Y
N
S
I
V
W
I
K
E
N
N
L
E
--
E
CG
L
E
L
Y
F
I
Q
D
M
E
I
L
G
K
V
T
T
H
E
L
K
E
G
G
E
S
I
R
V
T
E
E
N
K
E
E
Y
I
M
L
L
T
D
W
R
F
T
R
G
V
E
E
Q
T
K
A
F
L
D
G
F
N
E
V
A
P
L
E
W
L
R
Y
F
D
E
K
E
L
E
L
M
L
C
G
M
Q
E
I
D
M
S
D
W
Q
K
S
T
I
Y
R
H
-
Y
T
K
N
S
K
Q
I
Q
W
F
W
Q
V
V
K
E
M
D
N
E
K
R
I
R
L
L
Q
F
V
T
G
T
C
R
L
P
V
G
G
F
A
E
L
I
G
S
N
G
P
Q
K
F
C
I
D
K
V
G
-
K
E
T
W
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
R
E
K
L
L
Y
A
I
E
E
T
E
------
9
PsiBlast_PDB
75.49
81%
-
- C1 -
-
4BBN
-
A:
[519-895]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
D
Y
K
R
K
Y
E
F
F
R
R
K
L
K
K
Q
N
D
I
P
N
K
F
E
M
K
L
R
R
A
T
V
L
E
D
S
Y
R
R
I
M
G
V
K
R
A
D
F
L
K
A
R
L
W
I
E
F
D
G
E
K
G
L
D
Y
G
G
V
A
R
E
W
F
F
L
I
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
S
G
I
-
N
P
D
H
L
S
Y
F
K
F
I
G
R
V
A
G
M
A
V
Y
H
G
K
L
L
D
G
F
F
I
R
P
F
Y
K
M
M
L
H
K
P
I
T
L
H
D
M
E
S
V
D
S
E
Y
Y
N
S
L
R
W
I
L
E
N
D
P
T
--
E
--
L
D
L
R
F
I
I
D
E
E
L
F
G
Q
T
H
Q
H
E
L
K
N
G
G
S
E
I
V
V
T
N
K
N
K
K
E
Y
I
Y
L
V
I
Q
W
R
F
V
N
R
I
Q
K
Q
M
A
A
F
K
E
G
F
F
E
L
I
P
Q
D
L
I
K
I
F
D
E
N
E
L
E
L
L
M
S
G
L
G
D
V
D
V
N
D
W
R
E
H
T
K
Y
K
N
G
Y
S
A
N
H
Q
V
I
Q
W
F
W
K
A
V
L
M
M
D
S
E
K
R
I
R
L
L
Q
F
V
T
G
T
S
R
V
P
M
N
G
F
A
E
L
Y
G
S
N
G
P
Q
S
F
T
V
E
Q
W
G
-
T
P
E
K
L
P
R
A
H
T
C
F
N
R
L
D
L
P
P
Y
E
S
F
E
E
L
W
D
K
L
Q
M
A
I
E
N
T
Q
G
F
----
42
HHSearch
75.10
52%
-58
- C1 -
-
1ND7
-
WWP1_HUMAN
A:
[546-916]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
R
W
K
L
A
H
F
R
Y
L
C
Q
S
N
-
A
L
P
S
H
V
K
I
N
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
A
L
-
K
P
Y
D
L
R
R
R
L
Y
V
I
F
R
G
E
E
G
L
D
Y
G
G
L
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
S
T
I
-
N
P
D
H
L
S
Y
F
C
F
I
G
R
F
I
A
M
A
L
F
H
G
K
F
I
D
T
G
F
S
L
P
F
Y
K
R
M
L
S
K
K
L
T
I
K
D
L
E
S
I
D
T
E
F
Y
N
S
L
I
W
I
R
D
N
N
I
E
EC
G
--
L
E
M
Y
F
S
V
D
M
E
I
L
G
K
V
T
S
H
D
L
K
L
G
G
S
N
I
L
V
T
E
E
N
K
D
E
Y
I
G
L
M
T
E
W
R
F
S
R
G
V
Q
E
Q
T
K
A
F
L
D
G
F
N
E
V
V
P
L
Q
W
L
Q
Y
F
D
E
K
E
L
E
V
M
L
C
G
M
Q
E
V
D
L
A
D
W
Q
R
N
T
V
Y
R
H
-
Y
T
R
N
S
K
Q
I
I
W
F
W
Q
F
V
K
E
T
D
N
E
V
R
M
R
L
L
Q
F
V
T
G
T
C
R
L
P
L
G
G
F
A
E
L
M
G
S
N
G
P
Q
K
F
C
I
E
K
V
G
-
K
D
T
W
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
K
E
K
L
L
F
A
I
E
E
T
-------
17
PsiBlast_PDB
74.75
47%
-38
- C1 -
-
5TJ8
-
WWP2_HUMAN
A:
[25-446]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
W
Q
R
P
T
A
E
Y
V
R
N
Y
E
Q
W
Q
S
Q
R
N
Q
L
Q
G
A
M
Q
-------
H
F
S
Q
R
F
L
Y
Q
S
--------------
S
----
G
S
P
G
A
Y
D
R
S
F
R
W
K
Y
H
Q
F
R
F
L
C
H
S
N
A
-
L
P
S
H
V
K
I
S
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
N
M
K
-
P
Y
D
L
R
R
R
L
Y
I
I
M
R
G
E
E
-
L
D
Y
G
G
I
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
S
S
I
-
N
P
D
H
L
T
Y
F
R
F
I
G
R
F
I
A
M
A
L
Y
H
G
K
F
I
D
T
G
F
T
L
P
F
Y
K
R
M
L
N
K
R
P
T
L
K
D
L
E
S
I
D
P
E
F
Y
N
S
I
V
W
I
--------
E
CG
L
E
L
Y
F
I
Q
D
M
E
---
K
V
T
T
H
E
L
K
E
G
G
E
S
I
R
V
T
E
E
N
K
E
E
Y
I
M
L
L
T
D
W
R
F
T
R
G
V
E
E
Q
T
K
A
F
L
D
G
F
N
E
V
A
P
L
E
W
L
R
Y
F
D
E
K
E
L
E
L
M
L
C
G
M
Q
E
I
D
M
S
D
W
Q
K
S
T
I
Y
R
H
-
Y
T
K
N
S
K
Q
I
Q
W
F
W
Q
V
V
K
E
M
D
N
E
K
R
I
R
L
L
Q
F
V
T
G
T
C
R
L
P
V
G
G
F
A
E
L
I
G
S
N
G
P
Q
K
F
C
I
D
K
V
G
-
K
E
T
W
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
R
E
K
L
L
Y
A
I
E
E
T
-------
46
HHSearch
74.28
56%
-46
- C1 -
-
5HPL
-
RSP5_YEAST
B:
[433-802]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
F
R
R
K
V
I
Y
F
R
S
Q
P
A
L
R
-
I
L
P
G
Q
C
H
I
K
V
R
R
K
N
I
F
E
D
A
Y
Q
E
I
M
R
Q
-
T
P
E
D
L
K
K
R
L
M
I
K
F
D
G
E
E
G
L
D
Y
G
G
V
S
R
E
F
F
F
L
L
S
H
E
M
F
N
P
F
Y
C
L
F
E
Y
S
A
Y
D
N
Y
T
I
Q
I
N
P
N
S
G
I
-
N
P
E
H
L
N
Y
F
K
F
I
G
R
V
V
G
L
G
V
F
H
R
R
F
L
D
A
F
F
V
G
A
L
Y
K
M
M
L
R
K
K
V
V
L
Q
D
M
E
G
V
D
A
E
V
Y
N
S
L
N
W
M
L
E
N
S
I
D
G-
V
--
L
D
L
T
F
S
A
D
D
E
R
F
G
E
V
V
T
V
D
L
K
P
D
G
R
N
I
E
V
T
D
G
N
K
K
E
Y
V
E
L
Y
T
Q
W
R
I
V
D
R
V
Q
E
Q
F
K
A
F
M
D
G
F
N
E
L
I
P
E
D
L
V
T
V
F
D
E
R
E
L
E
L
L
I
G
G
I
A
E
I
D
I
E
D
W
K
K
H
T
D
Y
R
-
G
Y
Q
E
S
D
E
V
I
Q
W
F
W
K
C
V
S
E
W
D
N
E
Q
R
A
R
L
L
Q
F
T
T
G
T
S
R
I
P
V
N
G
F
K
D
L
Q
G
S
D
G
P
R
R
F
T
I
E
K
A
G
-
E
V
Q
Q
L
P
K
S
H
T
C
F
N
R
V
D
L
P
Q
Y
V
D
Y
D
S
M
K
Q
K
L
T
L
A
V
E
E
--------