@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PTN6_MOUSE: (2018-07-13 )
MVRWFHRDLSGPDAETLLKGRGVPGSFLARPSRKNQGDFSLSVRVDDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGILQDRDGTIIHLKYPLNCSDPTSERWYHGHISGGQAESLLQAKGEPWTFLVRESLSQPGDFVLSVLNDQPKAGPGSPLRVTHIKVMCEGGRYTVGGSETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYVKNQLLGPDENSKTYIASQGCLDATVNDFWQMAWQENTRVIVMTTREVEKGRNKCVPYWPEVGTQRVYGLYSVTNSREHDTAEYKLRTLQISPLDNGDLVREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMESISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEIIQSQKGQESEYGNITYPPAVRSAHAKASRTSSKHKEEVYENVHSKSKKEEKVKKQRSADKEKNKGSLKRK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.........160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......---320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
V
R
W
F
HRDLSGP
D
A
E
T
L
LKGRGV
P
G
S
F
LARPSRKNQG
D
F
S
L
S
V
R
VDD
Q
V
T
H
I
R
I
QNSGD
F
Y
DLYGG
E
K
F
A
T
L
T
E
L
V
E
Y
Y
T
Q
Q
QGILQDRDG
T
I
I
H
L
K
YPLNCSDPTSE
R
W
Y
H
GHISGG
Q
A
E
S
L
L
Q
AKGE
P
W
T
F
L
V
R
E
SLSQ
P
G
D
F
V
L
S
V
L--NDQPKAGPGS
P
L
R
V
T
H
I
K
V
M
C
EGG
R
Y
T
VGGS
E
T
F
D
S
L
T
D
L
V
E
H
F
K
KTGIEEAS
G
A
F
V
Y
L
RQP
Y
Y
A
TRV
N
A
A
D
I
E
N
R
V
L
E
LNKKQESEDTAKAG
F
W
E
E
F
E
S
L
Q
K
Q
E
V
K
N
L
H
Q
R
LEGQRPENKSKNRYKNILPFDH
S
R
V
I
L
QGRDSNIPGSDYI
N
A
N
Y
V
K
NQLLGPDENS
K
---
T
Y
I
ASQGC
L
D
A
T
V
N
D
F
W
Q
M
A
W
QEN
T
R
V
I
V
M
T
T
R
E
V
EKGRNKCVPYWPEVGT
Q
R
V
Y
G
L
Y
SVTNSREHDTA
E
Y
K
L
R
T
L
Q
I
SPLD
N
G
D
L
V
R
E
I
W
H
Y
QYLSWPDHGVPSEP
G
G
V
L
S
F
L
D
Q
I
N
Q
R
Q
E
SLPHAG
P
I
I
V
H
CSAGIGRT
G
T
I
I
V
I
D
M
L
M
E
S
ISTKGLDCD
I
D
I
Q
K
T
I
Q
M
V
R
A
Q
RSGM
V
Q
TEA
Q
Y
K
F
I
Y
V
A
I
A
Q
F
I
E
T
T
K
K
K
L
E
I
I
Q
SQKGQESEYGNITYPP
A
V
R
S
A
HAKASRTSS
K
H
K
E
E
V
Y
E
N
V
H
SK
S
K
K
E
E
K
V
K
K
Q
RSADKEKNKGSLKRK
1
PsiBlast_PDB
91.33
94%
-81
- C1 -
-
3PS5
-
PTN6_HUMAN
A:
[1-529]
M
V
R
W
F
H
R
D
L
S
G
L
D
A
E
T
L
L
K
G
R
G
V
H
G
S
F
L
A
R
P
S
R
K
N
Q
G
D
F
S
L
S
V
R
V
G
D
Q
V
T
H
I
R
I
Q
N
S
G
D
F
Y
D
L
Y
G
G
E
K
F
A
T
L
T
E
L
V
E
Y
Y
T
Q
Q
Q
G
V
L
Q
D
R
D
G
T
I
I
H
L
K
Y
P
L
N
C
S
D
P
T
S
E
R
W
Y
H
G
H
M
S
G
G
Q
A
E
T
L
L
Q
A
K
G
E
P
W
T
F
L
V
R
E
S
L
S
Q
P
G
D
F
V
L
S
V
L
--
S
D
Q
P
K
A
G
P
G
S
P
L
R
V
T
H
I
K
V
M
C
E
G
G
R
Y
T
V
G
G
L
E
T
F
D
S
L
T
D
L
V
E
H
F
K
K
T
G
I
E
E
A
S
G
A
F
V
Y
L
R
Q
P
Y
Y
A
T
R
V
N
A
A
D
I
E
N
R
V
L
E
L
N
K
K
Q
E
S
E
D
T
A
K
A
G
F
W
E
E
F
E
S
L
Q
K
Q
E
V
K
N
L
H
Q
R
L
E
G
Q
R
P
E
N
K
G
K
N
R
Y
K
N
I
L
P
F
D
H
S
R
V
I
L
Q
G
R
D
S
N
I
P
G
S
D
Y
I
N
A
N
Y
I
K
N
Q
L
L
G
P
D
E
N
A
K
---
T
Y
I
A
S
Q
G
C
L
E
A
T
V
N
D
F
W
Q
M
A
W
Q
E
N
S
R
V
I
V
M
T
T
R
E
V
E
K
G
R
N
K
C
V
P
Y
W
P
E
V
G
M
Q
R
A
Y
G
P
Y
S
V
T
N
C
G
E
H
D
T
T
E
Y
K
L
R
T
L
Q
V
S
P
L
D
N
G
D
L
I
R
E
I
W
H
Y
Q
Y
L
S
W
P
D
H
G
V
P
S
E
P
G
G
V
L
S
F
L
D
Q
I
N
Q
R
Q
E
S
L
P
H
A
G
P
I
I
V
H
S
S
A
G
I
G
R
T
G
T
I
I
V
I
D
M
L
M
E
N
I
S
T
K
G
L
D
C
D
I
D
I
Q
K
T
I
Q
M
V
R
A
Q
R
S
G
M
V
Q
T
E
A
Q
Y
K
F
I
Y
V
A
I
A
Q
F
I
E
T
T
K
K
K
L
E
V
L
Q
S
Q
------------------------------------------------------------------
18
PsiBlast_PDB
69.43
94%
-76
- C1 -
-
1FPR
-
PTN6_HUMAN
A:
[1-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
W
E
E
F
E
S
L
Q
K
Q
E
V
K
N
L
H
Q
R
L
E
G
Q
R
P
E
N
K
G
K
N
R
Y
K
N
I
L
P
F
D
H
S
R
V
I
L
Q
G
R
D
S
N
I
P
G
S
D
Y
I
N
A
N
Y
I
K
N
Q
L
L
G
P
D
E
N
A
K
---
T
Y
I
A
S
Q
G
C
L
E
A
T
V
N
D
F
W
Q
M
A
W
Q
E
N
S
R
V
I
V
M
T
T
R
E
V
E
K
G
R
N
K
C
V
P
Y
W
P
E
V
G
M
Q
R
A
Y
G
P
Y
S
V
T
N
C
G
E
H
D
T
T
E
Y
K
L
R
T
L
Q
V
S
P
L
D
N
G
D
L
I
R
E
I
W
H
Y
Q
Y
L
S
W
P
D
H
G
V
P
S
E
P
G
G
V
L
S
F
L
D
Q
I
N
Q
R
Q
E
S
L
P
H
A
G
P
I
I
V
H
S
S
A
G
I
G
R
T
G
T
I
I
V
I
D
M
L
M
E
N
I
S
T
K
G
L
D
C
D
I
D
I
Q
K
T
I
Q
M
V
R
A
Q
R
S
G
M
V
Q
T
E
A
Q
Y
K
F
I
Y
V
A
I
A
Q
F
I
E
T
T
K
K
K
L
E
V
L
---------------------------------------------------------------------
5
PsiBlast_PDB
69.19
58%
-8
- C1 -
-
5XZR
1
PTN11_HUMAN
A:
[28-553]
--
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
K
S
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
A
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
E
K
N
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
S
G
K
E
A
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
Q
S
H
P
G
D
F
V
L
S
V
R
T
G
D
D
K
G
E
S
N
D
G
K
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
K
L
A
E
---
K
V
K
Q
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
N
E
P
V
S
D
Y
I
N
A
N
I
I
M
P
----------K--
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
Q
R
R
I
E
-----------------------------------------------------------------------
15
PsiBlast_PDB
69.14
93%
-73
- C1 -
-
4HJQ
-
PTN6_HUMAN
A:
[23-303]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
W
E
E
F
E
S
L
Q
K
Q
E
V
K
N
L
H
Q
R
L
E
G
Q
R
P
E
N
K
G
K
N
R
Y
K
N
I
L
P
F
D
H
S
R
V
I
L
Q
G
R
D
S
N
I
P
G
S
D
Y
I
N
A
N
Y
I
K
N
Q
L
L
G
P
D
E
N
A
K
---
T
Y
I
A
S
Q
G
C
L
E
A
T
V
N
D
F
W
Q
M
A
W
Q
E
N
S
R
V
I
V
M
T
T
R
E
V
E
K
G
R
N
K
C
V
P
Y
W
P
E
V
G
M
Q
R
A
Y
G
P
Y
S
V
T
N
C
G
E
H
D
T
T
E
Y
K
L
R
T
L
Q
V
S
P
L
D
N
G
D
L
I
R
E
I
W
H
Y
Q
Y
L
S
W
P
D
H
G
V
P
S
E
P
G
G
V
L
S
F
L
D
Q
I
N
Q
R
Q
E
S
L
P
H
A
G
P
I
I
V
H
S
S
A
G
I
G
R
T
G
T
I
I
V
I
D
M
L
M
E
N
I
S
T
K
G
L
D
C
D
I
D
I
Q
K
T
I
Q
M
V
R
A
Q
R
S
G
M
V
Q
T
E
A
Q
Y
K
F
I
Y
V
A
I
A
Q
F
I
E
T
T
K
K
K
L
------------------------------------------------------------------------
17
PsiBlast_PDB
68.75
93%
-72
- C1 -
-
4GRZ
-
PTN6_HUMAN
A:
[3-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
W
E
E
F
E
S
L
Q
K
Q
E
V
K
N
L
H
Q
R
L
E
G
Q
R
P
E
N
K
G
K
N
R
Y
K
N
I
L
P
F
D
H
S
R
V
I
L
Q
G
R
D
S
N
I
P
G
S
D
Y
I
N
A
N
Y
I
K
N
Q
L
L
G
P
D
E
N
A
K
---
T
Y
I
A
S
Q
G
C
L
E
A
T
V
N
D
F
W
Q
M
A
W
Q
E
N
S
R
V
I
V
M
T
T
R
E
V
E
K
G
R
N
K
C
V
P
Y
W
P
E
V
G
M
Q
R
A
Y
G
P
Y
S
V
T
N
C
G
E
H
D
T
T
E
Y
K
L
R
T
L
Q
V
S
P
L
D
N
G
D
L
I
R
E
I
W
H
Y
Q
Y
L
S
W
P
D
H
G
V
P
S
E
P
G
G
V
L
S
F
L
D
Q
I
N
Q
R
Q
E
S
L
P
H
A
G
P
I
I
V
H
S
S
A
G
I
G
R
T
G
T
I
I
V
I
D
M
L
M
E
N
I
S
T
K
G
L
D
C
D
I
D
I
Q
K
T
I
Q
M
V
R
A
Q
R
S
G
M
V
Q
T
E
A
Q
Y
K
F
I
Y
V
A
I
A
Q
F
I
E
T
T
K
K
K
L
E
-----------------------------------------------------------------------
2
PsiBlast_PDB
67.24
58%
-16
- C1 -
-
4NWG
8
PTN11_HUMAN
A:
[5-534]
--
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
--
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
E
K
N
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
S
G
--
A
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
D
S
Q
S
H
P
G
D
F
V
L
S
V
R
T
G
D
---------
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
-----------
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
N
-
P
V
S
D
Y
I
N
A
N
I
I
M
P
E
---------K
K
-
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
Q
R
R
I
E
E
E
Q
K
-------------------------------------------------------------------
10
PsiBlast_PDB
66.57
59%
-15
- C1 -
-
6BMX
1
PTN11_HUMAN
A:
[6-525]
--
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
K
S
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
E
-
N
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
S
G
K
E
A
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
---
P
G
D
F
V
L
S
V
R
T
G----------
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
K
L
--------
Q
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
--
P
V
S
D
Y
I
N
A
N
I
I
M
P
E
---------K--
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
-----------------------------------------------------------------------------
6
PsiBlast_PDB
66.56
59%
-12
- C1 -
-
6BMR
1
PTN11_HUMAN
A:
[6-525]
--
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
K
S
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
E
-
N
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
S
G
K
E
A
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
Q
--
P
G
D
F
V
L
S
V
R
T
G----------
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
K
L
--------
Q
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
--
P
V
S
D
Y
I
N
A
N
I
I
M
P
E
---------K--
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
-----------------------------------------------------------------------------
9
PsiBlast_PDB
66.45
59%
-20
- C1 -
-
6BMW
2
PTN11_HUMAN
A:
[6-525]
--
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
K
--
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
----
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
---
E
A
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
---
P
G
D
F
V
L
S
V
R
T
G----------
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
K
L
--------
Q
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
------
P
V
S
D
Y
I
N
A
N
I
I
M
P
----------K--
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
-----------------------------------------------------------------------------
8
PsiBlast_PDB
65.76
59%
-16
- C1 -
-
6BMV
1
PTN11_HUMAN
A:
[6-525]
--
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
K
S
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
--
N
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
S
G
K
E
A
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
Q
--
P
G
D
F
V
L
S
V
R
T
G----------
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
---------
K
Q
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
------
P
V
S
D
Y
I
N
A
N
I
I
M
P
E
---------K--
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
-----------------------------------------------------------------------------
3
PsiBlast_PDB
65.15
59%
-10
- C1 -
-
4OHI
-
PTN11_HUMAN
A:
[5-528]
--
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
K
S
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
E
K
N
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
S
G
K
E
A
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
Q
S
H
P
G
D
F
V
L
S
V
R
T
G
D
D
K
G
E
S
N
D
G
K
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
-------
K
V
K
Q
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
-------
S
D
Y
I
N
A
N
I
I
M
P
E
---------K
K
-
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
E
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
Q
R
R
-------------------------------------------------------------------------
11
PsiBlast_PDB
64.30
59%
-1
- C1 -
-
6BMY
2
PTN11_HUMAN
A:
[6-525]
--
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
--
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
---
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
-----
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
---
P
G
D
F
V
L
S
V
R
T
G----------
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
K
L
--------
Q
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
--
P
V
S
D
Y
I
N
A
N
I
I
M
P
----------PKK
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
-----------------------------------------------------------------------------
7
PsiBlast_PDB
63.94
59%
-3
- C1 -
-
6BMU
3
PTN11_HUMAN
A:
[6-525]
--
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
--
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
---
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
-----
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
---
P
G
D
F
V
L
S
V
R
T
G----------
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
K
L
--------
Q
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
--
P
V
S
D
Y
I
N
A
N
I
I
M
P
----------PKK
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
-----------------------------------------------------------------------------
13
PsiBlast_PDB
62.09
94%
-87
- C1 -
-
4GS0
-
PTN6_HUMAN
A:
[23-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
W
E
E
F
E
S
L
Q
K
Q
E
V
K
N
L
H
Q
R
L
E
G
Q
R
P
E
N
K
G
K
N
R
Y
K
N
I
L
P
F
D
H
S
R
V
I
L
Q
G
R
D
S
N
I
P
G
S
D
Y
I
N
A
N
Y
I
K
N
Q
L
L
------
K
---
T
Y
I
A
S
Q
G
C
L
E
A
T
V
N
D
F
W
Q
M
A
W
Q
E
N
S
R
V
I
V
M
T
T
R
E
V
E
K
G
R
N
K
C
V
P
Y
W
P
E
V
G
M
Q
R
A
Y
G
P
Y
S
V
T
N
C
G
E
H
D
T
T
E
Y
K
L
R
T
L
Q
V
S
P
L
D
N
G
D
L
I
R
E
I
W
H
Y
Q
Y
L
S
W
P
D
H
G
V
P
S
E
P
G
G
V
L
S
F
L
D
Q
I
N
Q
R
Q
E
S
L
P
H
A
G
P
I
I
V
H
C
S
A
G
I
G
R
T
G
T
I
I
V
I
D
M
L
M
E
N
I
S
T
K
G
L
D
C
D
I
D
I
Q
K
T
I
Q
M
V
R
A
Q
R
S
G
M
V
Q
T
E
A
Q
Y
K
F
I
Y
V
A
I
A
Q
F
I
E
T
T
K
K
K
L
E
V
L
Q
--------------------------------------------------------------------
4
PsiBlast_PDB
61.85
59%
-14
- C- -
-
4OHH
-
PTN11_HUMAN
A:
[5-528]
--
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
K
S
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
E
K
N
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
S
G
K
E
A
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
Q
S
H
P
G
D
F
V
L
S
V
R
T
G
D
D
----
N
D
G
K
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
-----------
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
-------
S
D
Y
I
N
A
N
I
I
M
P
E
---------K
K
-
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
P
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
Q
R
R
-------------------------------------------------------------------------
16
PsiBlast_PDB
61.58
93%
-86
- C1 -
-
4GRY
-
PTN6_HUMAN
A:
[3-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
W
E
E
F
E
S
L
Q
K
Q
E
V
K
N
L
H
Q
R
L
E
G
Q
R
P
E
N
K
G
K
N
R
Y
K
N
I
L
P
F
D
H
S
R
V
I
L
Q
G
R
D
S
N
I
P
G
S
D
Y
I
N
A
N
Y
I
K
N
Q
L
L
----
N
A
K
---
T
Y
I
A
S
Q
G
C
L
E
A
T
V
N
D
F
W
Q
M
A
W
Q
E
N
S
R
V
I
V
M
T
T
R
E
V
--------
P
Y
W
P
E
V
G
M
Q
R
A
Y
G
P
Y
S
V
T
N
C
G
E
H
D
T
T
E
Y
K
L
R
T
L
Q
V
S
P
L
D
N
G
D
L
I
R
E
I
W
H
Y
Q
Y
L
S
W
P
D
H
G
V
P
S
E
P
G
G
V
L
S
F
L
D
Q
I
N
Q
R
Q
E
S
L
P
H
A
G
P
I
I
V
H
S
S
A
G
I
G
R
T
G
T
I
I
V
I
D
M
L
M
E
N
I
S
T
K
G
L
D
C
D
I
D
I
Q
K
T
I
Q
M
V
R
A
Q
R
S
G
M
V
Q
T
E
A
Q
Y
K
F
I
Y
V
A
I
A
Q
F
I
E
T
T
K
K
K
L
E
V
----------------------------------------------------------------------
12
PsiBlast_PDB
59.62
94%
-77
- C1 -
-
1GWZ
-
PTN6_HUMAN
A:
[250-532]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
S
L
Q
K
Q
E
V
K
N
L
H
Q
R
L
E
G
Q
R
P
E
N
K
G
K
N
R
Y
K
N
I
L
P
F
D
H
S
R
V
I
L
Q
G
R
D
S
N
I
P
G
S
D
Y
I
N
A
N
Y
I
K
N
Q
L
L
G
P
D
E
N
A
K
---
T
Y
I
A
S
Q
G
C
L
E
A
T
V
N
D
F
W
Q
M
A
W
Q
E
N
S
R
V
I
V
M
T
T
R
E
V
E
K
G
R
N
K
C
V
P
Y
W
P
E
V
G
M
Q
R
A
Y
G
P
Y
S
V
T
N
C
G
E
H
D
T
T
E
Y
K
L
R
T
L
Q
V
S
P
---
G
D
L
I
R
E
I
W
H
Y
Q
Y
L
S
W
P
D
H
G
V
P
S
E
P
G
G
V
L
S
F
L
D
Q
I
N
Q
R
Q
E
S
L
P
H
A
G
P
I
I
V
H
C
S
A
G
I
G
R
T
G
T
I
I
V
I
D
M
L
M
E
N
I
S
T
K
G
L
D
C
D
I
D
I
Q
K
T
I
Q
M
V
R
A
Q
R
S
G
M
V
Q
T
E
A
Q
Y
K
F
I
Y
V
A
I
A
Q
F
I
E
T
T
K
K
K
L
E
V
L
Q
S
Q
K
-----------------------------------------------------------------
32
HHSearch
56.67
57%
-82
- C1 -
-
3B7O
-
PTN11_HUMAN
A:
[33-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
N
E
P
V
S
D
Y
I
N
A
N
I
I
M
P
E
--------
K
---
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
Q
R
--------------------------------------------------------------------------
53
HHSearch
55.70
37%
-107
- C1 -
-
2HC1
-
A:
[8-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
K
I
N
Q
F
E
G
H
F
M
K
L
Q
A
D
------
S
N
Y
L
L
S
K
E
Y
E
E
L
K
D
V
G
R
N
--
Q
S
C
D
I
A
L
L
P
E
N
R
G
K
N
R
Y
N
N
I
L
P
Y
D
A
T
R
V
K
L
S
G
------
G
S
D
Y
I
N
A
S
Y
I
P
G
N
-----
N
F
R
R
---
E
Y
I
V
T
Q
G
P
L
P
G
T
K
D
D
F
W
K
M
V
W
E
Q
N
V
H
N
I
V
M
V
T
Q
C
V
E
K
G
R
V
K
C
D
H
Y
W
P
A
D
Q
D
S
L
Y
Y
G
D
L
I
L
Q
M
L
S
E
S
V
L
P
E
W
T
I
R
E
F
K
I
C
G
E
E
Q
L
D
A
H
R
L
I
R
H
F
H
Y
T
V
W
P
D
H
G
V
P
E
T
T
Q
S
L
I
Q
F
V
R
T
V
R
D
Y
I
N
R
S
P
G
A
G
P
T
V
V
H
C
S
A
G
V
G
R
T
G
T
F
I
A
L
D
R
I
L
Q
Q
L
D
S
K
---
D
-
V
D
I
Y
G
A
V
H
D
L
R
L
H
R
V
H
M
V
Q
T
E
-
Q
Y
V
Y
L
H
Q
C
V
R
D
V
L
R
A
R
K
---------------------------------------------------------------------------
37
HHSearch
54.32
34%
-103
- C1 -
-
4RI5
2
PTN3_HUMAN
A:
[26-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
E
G
S
M
A
Q
L
K
K
G
L
-----
E
S
G
T
V
L
I
Q
F
E
Q
L
Y
R
K
K
P
G
L
--
A
I
T
F
A
K
L
P
Q
N
L
D
K
N
R
Y
K
D
V
L
P
Y
D
T
T
R
V
L
L
Q
G
------
N
E
D
Y
I
N
A
S
Y
V
N
M
E
I
P
-
A
A
N
L
V
N
---
K
Y
I
A
T
Q
G
P
L
P
H
T
C
A
Q
F
W
Q
V
V
W
D
Q
K
L
S
L
I
V
M
L
T
T
L
T
E
R
G
R
T
K
C
H
Q
Y
W
P
D
P
P
D
V
M
N
H
G
G
F
H
I
Q
C
Q
S
E
D
C
T
I
A
Y
V
S
R
E
M
L
V
T
N
T
Q
-
T
G
E
E
H
T
V
T
H
L
Q
Y
V
A
W
P
E
H
G
V
P
D
D
S
S
D
F
L
E
F
V
N
Y
V
R
S
L
R
---
V
D
S
E
P
V
L
V
H
C
S
A
G
I
G
R
T
G
V
L
V
T
M
E
T
A
M
C
L
T
E
R
N
L
---
P
I
Y
P
L
D
I
V
R
K
M
R
D
Q
R
A
M
M
V
Q
T
S
S
Q
Y
K
F
V
C
E
A
I
L
R
V
Y
E
E
G
L
---------------------------------------------------------------------------