@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AAPK1_HUMAN: (2018-07-12 )
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.-......150.......160.......170..----...-.---.180.......190.......200.......210.......220.......230.......240.......250.......260......-----.270.......280--.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MR
R
L
S
S
W
R
K
M
A
T
A
E
KQKHDG
R
V
K
I
G
H
Y
I
LGDTLGVG
T
F
G
K
V
K
VGKHELTG
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
FRHP
H
I
I
K
L
Y
Q
V
IST
P
S
D
I
F
M
V
M
E
Y
VSG
G
E
L
F
D
Y
I
C
KNGRLD
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
HRDLKPE
N
V
L
L
DAHMNA
K
I
A
D
F
G
L
S
N
M----MSD-G---
E
F
L
R
TSCGSPNYAA
P
E
VISGRLYAGPEVDIWSS
G
V
I
L
Y
A
L
L
CGTLPFDDD
H
V
P
T
L
F
K
K
I
CDGIFYTPQYL
N
P
S
V
I
S
L
L
K
H
M
L
QVDPM
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
K
YLFPEDPSYSSTMI
D
D
E
A
L
K
E
V
C
E
KFEC
S
E
E
E
V
L
S
C
L
YNRNHQ
D
P
L
A
V
A
Y
H
L
I
ID
N
R
R
I
M
NEAK
D
F
Y
L
ATSP
P
D
S
FLDDHHLTRPHPERV
P
F
L
V
AETPRARH
T
L
D
ELNP
Q
K
S
K
H
QGV
R
K
A
K
W
H
LGIRSQSR
P
N
D
I
M
A
E
V
C
R
A
I
K
QLDY
E
W
K
VVN
P
Y
Y
L
R
V
RRKNPVTSTY
S
K
M
S
L
Q
L
Y
Q
VDS
R
T
Y
L
L
D
FRSI
D
D
E
I
TEAKSGTATPQRSGSVS
N
Y
R
S
CQRSDSDAEAQGKSS
E
V
S
L
T
S
SVTSLDSSPVDLTPRPGS
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
LAQ
2
PsiBlast_PDB
89.87
98%
-119
- C1 -
-
4RER
3
AAPK1_HUMAN
A:
[1-540]
-------------------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
-
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
K
Y
L
F
P
E
D
P
S
Y
S
----
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
D
----
D
H
H
L
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
-------------------
R
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
G
I
T
------------------------------------------------------
P
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
9
PsiBlast_PDB
88.25
75%
-134
- C1 -
-
5ISO
3
?
A:
[9-551]
-------------------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
-
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
S
Y
L
F
P
E
D
P
S
Y
D
A
N
V
I
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
----------
L
K
P
H
P
E
R
M
P
P
L
I
A
D
S
-------------------
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
---------------------------------------------------------
P
R
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
8
PsiBlast_PDB
88.16
80%
-136
- C1 -
-
5EZV
2
AAPK1_HUMAN (first)
A:
[22-559]
------------------
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
-
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
S
Y
L
F
P
E
D
P
S
Y
D
A
N
V
I
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
-------------
R
P
H
P
E
R
V
P
F
--------------------------
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
-----------------------------------------------------------
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
10
PsiBlast_PDB
81.84
75%
-125
- C1 -
-
4CFE
3
AAPK2_HUMAN
A:
[27-570]
------------------
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
-
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
S
Y
L
F
P
E
D
P
S
Y
D
A
N
V
I
D
D
E
A
V
K
E
-------------------------
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
----------
L
K
P
H
P
E
R
M
P
P
L
I
A
D
-------------------
A
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
------------------------------------------------------------
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
7
PsiBlast_PDB
81.12
98%
-123
- C1 -
-
4CFH
2
AAPK1_RAT
A:
[29-489]
--------------------
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
-
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
K
Y
L
F
P
E
D
----------------------------------------
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
D
S
F
L
D
D
H
H
L
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
R
A
-------------------
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
I
------------------------------------------------------------------------------
12
PsiBlast_PDB
81.05
75%
-130
- C1 -
-
4ZHX
2
AAPK2_HUMAN
A:
[22-563]
-------------------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
-
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
G
--
L
P
S
Y
L
F
P
E
D
P
S
Y
D
A
N
V
I
D
D
E
A
V
K
E
V
C
E
----------------------
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
------------------------------------------------
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
-----------------------------------------------------------
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
--
4
PsiBlast_PDB
80.74
89%
-125
- C1 -
-
4QFR
2
?
A:
[11-503]
-------------------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
-
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
K
Y
L
F
---------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
----------------
S
---------------------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
3
PsiBlast_PDB
80.43
89%
-121
- C1 -
-
4QFG
1
AAPK1_RAT
A:
[11-503]
-------------------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
-
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
K
Y
L
F
P
---------------------------------------------------------------------------------------------------------------------
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
------------
R
P
G
S
---------------------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
21
HHSearch
80.14
99%
-138
- C1 -
-
4RED
-
AAPK1_HUMAN
B:
[12-351]
--------------------
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
A
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
-
G
-----------
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
K
Y
L
F
P
E
D
P
S
Y
S
T
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
D
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
80.08
75%
-124
- C1 -
-
4CFF
2
AAPK2_HUMAN
A:
[27-570]
------------------
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
-
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
S
Y
L
F
P
E
D
P
S
Y
D
A
N
V
I
D
D
E
A
V
K
E
-------------------------
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
----------
L
K
P
H
P
E
R
M
P
P
L
I
A
--------------------
A
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
------------------------------------------------------------
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
1
PsiBlast_PDB
79.89
99%
-104
- C1 -
-
4REW
2
AAPK1_HUMAN
A:
[1-540]
-------------------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
-
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
K
Y
L
F
P
E
------------------------------------------------
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
D
-----
H
H
L
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
--------------------
R
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
G
--------------------------------------------------------
P
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
5
PsiBlast_PDB
79.88
89%
-126
- C1 -
-
4QFS
2
AAPK1_RAT
A:
[11-503]
-------------------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
-
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
K
Y
L
F
---------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
----------------
S
---------------------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
6
PsiBlast_PDB
78.92
89%
-124
- C1 -
-
5KQ5
2
?
A:
[12-503]
--------------------
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
-
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
K
Y
L
F
--------------------------------------------------------------------------------------------------------------------
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
---------------
P
G
S
---------------------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
22
HHSearch
74.02
99%
-127
- C1 -
-
4RED
-
AAPK1_HUMAN
A:
[12-351]
--------------------
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
A
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
-------------
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
----
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
K
Y
L
F
P
E
D
P
S
Y
S
T
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
D
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
73.86
98%
-127
- C1 -
-
4RED
-
AAPK1_HUMAN
A:
[12-351]
--------------------
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
A
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
-------------
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
----
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
K
Y
L
F
P
E
D
P
S
Y
S
T
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
D
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.80
90%
-132
- C1 -
-
3AQV
1
AAPK2_HUMAN
A:
[4-276]
-----------------
H
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
-
G
---
E
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
S
Y
L
F
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
71.00
90%
-133
- C1 -
-
3AQV
1
AAPK2_HUMAN
A:
[4-275]
-----------------
H
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
-
G
---
E
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
S
Y
L
F
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
66.71
90%
-140
- C1 -
-
2YZA
-
AAPK2_HUMAN
A:
[10-278]
--------------------
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
----
M
S
D
---------------
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
--
L
P
S
Y
L
F
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
61.51
41%
-117
- C1 -
-
2QNJ
-
MARK3_HUMAN
B:
[48-367]
------------------
D
E
Q
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
N
P
-
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
N
I
K
I
A
D
F
G
F
S
N
E
----
F
T
-------
K
L
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
I
N
A
G
--
H
E
E
D
E
L
K
P
F
V
E
P
E
L
D
I
S
D
Q
K
R
I
-
D
I
M
V
G
M
G
Y
S
Q
E
E
I
Q
E
S
L
S
K
M
-
K
Y
D
E
I
T
A
T
Y
L
L
L
G
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
60.55
42%
-133
- C1 -
-
5TVT
1
MELK_HUMAN
A:
[5-328]
-------------------
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
--
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
K
-------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
--
Y
N
Y
P
V
E
W
Q
S
K
N
-
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
-
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
57.77
42%
-124
- C1 -
-
5K00
1
MELK_HUMAN
A:
[4-326]
--------------------
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
--
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
K
----
P
---------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
--
Y
N
Y
P
V
E
W
Q
S
K
N
-
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
-
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
51.07
45%
-66
- C1 -
-
4CZT
3
CIPKN_ARATH
A:
[4-279]
-----------------
H
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
N
G
A
L
K
V
S
D
F
G
L
S
A
L
PQQV
R
E
D
-
G
----
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
P
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
K
G
YK
A
P
K
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
48.73
35%
-48
- C1 -
-
4CZT
4
CIPKN_ARATH
D:
[5-306]
------------------
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
N
G
A
L
K
V
S
D
F
G
L
S
A
L
----
P
Q
Q
-
V
RED
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
P
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
K
G
--
Y
K
A
P
K
F
E
N
A
------
D
V
S
L
D
D
V
D
A
I
F
D
D
S
----
N
L
V
V
E
R
--------------------
R
----
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
47.73
34%
-49
- C1 -
-
4CZU
3
CIPKN_ARATH
B:
[5-295]
------------------
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
N
G
A
L
K
V
S
D
F
G
L
S
A
L
----
P
Q
Q
-
V
RED
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
P
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
K
G
--
Y
K
A
P
K
F
E
------------
D
D
V
D
A
I
F
D
D
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
46.22
38%
-37
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[5-276]
---------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
D
G
---
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------