@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AIFM1_HUMAN: (2018-07-12 )
MFRCGGLAAGALKQKLVPLVRTVCVRSPRQRNRLPGNLFQRWHVPLELQMTRQMASSGASGGKIDNSVLVLIVGLSTVGAGAYAYKTMKEDEKRYNERISGLGLTPEQKQKKAALSASEGEEVPQDKAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIPPSTPAVPQAPVQGEDYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......-430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MFRCGGL
A
A
G
A
L
K
Q
K
L
V
P
L
V
R
T
V
CVRSPRQRNRL
P
G
N
L
F
Q
RWHV
P
L
E
L
Q
M
T
R
Q
M
A
SSGASGGKID
N
S
V
L
V
L
I
V
GLSTVGA
G
A
Y
A
Y
K
T
M
K
E
D
E
K
R
Y
N
E
R
ISGLGLT
P
E
Q
K
Q
K
K
AALSASEGEEVPQDKAPSHV
P
F
L
L
IGGG
T
A
A
F
A
A
A
R
S
IRARDPG
A
R
V
L
I
V
SEDPELPYMRPPLSKELWFSDDPNV
T
K
T
L
R
F
KQWNGKE
R
S
I
Y
FQPP
S
F
Y
V
SAQDLPHIENG
G
V
A
V
L
TG
K
K
V
V
Q
L
DVRD
N
M
V
KLNDG
S
Q
I
T
Y
E
K
C
L
I
ATGGTPR
S
L
S
A
I
D
RAGA
E
V
K
S
R
T
T
L
F
R
K
IG
D
F
R
S
L
E
K
I
S
R
E
V
K
S
I
T
I
I
GGGF
L
G
S
E
L
A
C
A
LGR
K
A
R
A
L
G
T
E
V
I
Q
LFPEKGN
M
G
K
I
L
P
E
Y
L
S
NW
T
M
E
K
V
R
R
EGV
K
V
M
P
N
A
I
V
Q
S
VGVSS
G
K
L
L
I
K
LKDG
R
K
VET
D
H
I
V
A
A
VGLEPN
V
E
L
A
KTGG
L
E
IDSDFG
G
F
R
V
N
A
E
L
Q
A-RS
N
I
W
V
AGD
A
A
C
F
Y
D
I
KLG
R
R
R
V
E
HHDH
A
V
V
SGRLAGENMTGAAKP
Y
W
HQS
M
F
W
SDLGPDVG
Y
E
A
I
G
LVDSSLPT
V
G
V
F
A
KATAQDNPKSATEQSGTGIRSESETESEA
S
E
I
TIPPSTPAVPQAPVQGEDYG
K
G
V
I
F
Y
LRD
K
V
V
V
G
I
V
L
W
N
I
F
NRM
P
I
A
R
K
I
IKDGE
Q
H
E
D
L
N
E
V
A
K
L
FNIHED
16
PsiBlast_PDB
94.84
91%
-98
- C1 -
-
1GV4
1
AIFM1_MOUSE
A:
[39-528]
-------------------------------------------------------------------------------------------------------------------------
T
V
P
Q
I
R
A
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
T
L
Q
F
R
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
N
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
H
L
D
V
R
G
N
M
V
K
L
N
D
G
S
Q
I
T
F
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
A
L
E
K
I
S
R
E
V
K
S
I
T
V
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
K
S
Q
A
S
G
I
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
Q
Y
L
S
N
W
T
M
E
K
V
K
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
G
G
R
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
T
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
K
S
A
T
E
Q
S
G
T
G
I
R
S
E
S
E
T
E
S
E
A
S
E
I
T
I
P
P
S
A
P
A
V
P
Q
V
P
V
E
G
E
D
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
V
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
N
I
H
--
9
PsiBlast_PDB
94.62
98%
-101
- C1 -
-
4LII
3
AIFM1_HUMAN
A:
[27-513]
----------------------------------------------------------------------------------------------------------------------------
Q
D
K
A
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
T
L
R
F
K
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
H
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
D
G
S
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
R
E
V
K
S
I
T
I
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
K
A
R
A
L
G
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
S
G
K
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
A
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
K
S
A
T
E
Q
S
G
T
G
I
R
S
E
S
E
T
E
S
E
A
S
E
I
T
I
P
P
-------------
D
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
I
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
N
I
H
--
32
HHSearch
93.85
100%
-102
- C1 -
-
4BV6
2
AIFM1_HUMAN
A:
[7-490]
------------------------------------------------------------------------------------------------------------------------------
K
A
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
T
L
R
F
K
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
H
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
D
G
S
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
R
E
V
K
S
I
T
I
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
K
A
R
A
L
G
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
S
G
K
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
A
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
K
S
A
T
E
Q
S
G
T
G
I
R
S
E
S
E
T
E
S
E
A
S
E
I
T
I
P
P
-------------
D
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
I
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
N
I
---
31
HHSearch
93.85
100%
-101
- C1 -
-
5FS8
1
AIFM1_HUMAN
A:
[23-509]
----------------------------------------------------------------------------------------------------------------------------
Q
D
K
A
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
-
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
T
L
R
F
K
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
H
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
D
G
S
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
R
E
V
K
S
I
T
I
I
G
E
G
F
L
G
S
E
L
A
C
A
L
G
R
K
A
R
A
L
G
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
S
G
K
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
A
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
K
S
A
T
E
Q
S
G
T
G
I
R
S
E
S
E
T
E
S
R
A
S
E
I
T
I
P
P
-------------
D
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
I
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
N
I
H
--
11
PsiBlast_PDB
93.85
100%
-102
- C1 -
-
4BV6
2
AIFM1_HUMAN
A:
[7-490]
------------------------------------------------------------------------------------------------------------------------------
K
A
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
T
L
R
F
K
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
H
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
D
G
S
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
R
E
V
K
S
I
T
I
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
K
A
R
A
L
G
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
S
G
K
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
A
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
K
S
A
T
E
Q
S
G
T
G
I
R
S
E
S
E
T
E
S
E
A
S
E
I
T
I
P
P
-------------
D
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
I
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
N
I
---
8
PsiBlast_PDB
93.63
99%
-101
- C1 -
-
5FS8
1
AIFM1_HUMAN
A:
[23-509]
----------------------------------------------------------------------------------------------------------------------------
Q
D
K
A
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
-
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
T
L
R
F
K
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
H
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
D
G
S
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
R
E
V
K
S
I
T
I
I
G
E
G
F
L
G
S
E
L
A
C
A
L
G
R
K
A
R
A
L
G
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
S
G
K
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
A
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
K
S
A
T
E
Q
S
G
T
G
I
R
S
E
S
E
T
E
S
R
A
S
E
I
T
I
P
P
-------------
D
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
I
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
N
I
H
--
4
PsiBlast_PDB
93.47
99%
-113
- C1 -
-
5FS6
1
AIFM1_HUMAN
A:
[25-511]
------------------------------------------------------------------------------------------------------------------------------
K
A
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
T
L
R
F
K
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
H
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
L
K
L
N
D
G
S
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
R
E
V
K
S
I
T
I
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
K
A
R
A
L
G
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
S
G
K
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
A
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
K
S
A
T
-------------------------------------
D
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
I
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
N
I
H
E
D
5
PsiBlast_PDB
93.32
99%
-114
- C1 -
-
5FS7
1
AIFM1_HUMAN
A:
[24-510]
-----------------------------------------------------------------------------------------------------------------------------
D
K
A
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
T
L
R
F
K
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
H
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
D
G
S
Q
I
T
Y
E
K
C
L
I
A
T
G
S
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
R
E
V
K
S
I
T
I
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
K
A
R
A
L
G
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
S
G
K
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
A
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
K
S
A
T
--------------------------------------
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
I
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
N
I
H
E
-
1
PsiBlast_PDB
93.14
99%
-125
- C1 -
-
5KVH
2
AIFM1_HUMAN
A:
[50-536]
-----------------------------------------------------------------------------------------------------------------------------
D
K
A
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
T
L
R
F
K
Q
A
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
H
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
D
G
S
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
R
E
V
K
S
I
T
I
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
K
A
R
A
L
G
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
S
G
K
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
A
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
-------------------------------------------------
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
I
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
N
I
H
E
-
6
PsiBlast_PDB
93.11
99%
-104
- C1 -
-
5FS9
2
AIFM1_HUMAN
A:
[24-510]
-----------------------------------------------------------------------------------------------------------------------------
D
K
A
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
T
L
R
F
K
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
H
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
D
G
S
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
R
E
V
K
S
I
T
I
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
K
A
R
A
L
G
T
E
V
I
Q
L
F
P
E
K
E
N
M
G
K
I
L
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
S
G
K
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
A
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
K
S
A
T
E
Q
S
G
T
G
I
R
S
----------------------------
D
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
I
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
N
I
H
E
-
2
PsiBlast_PDB
93.03
99%
-98
- C1 -
-
5KVI
3
AIFM1_HUMAN
A:
[53-537]
--------------------------------------------------------------------------------------------------------------------------------
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
T
L
R
F
K
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
H
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
D
G
S
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
R
E
V
K
S
I
T
I
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
K
A
R
A
L
G
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
S
G
K
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
A
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
A
I
D
S
D
F
G
G
F
A
V
N
A
E
L
Q
A
-
A
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
K
S
A
T
E
Q
S
G
T
G
I
R
S
E
S
E
T
E
S
E
A
S
E
I
T
I
P
------------
G
E
D
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
I
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
N
I
H
E
D
3
PsiBlast_PDB
92.67
100%
-119
- C1 -
-
4BUR
3
AIFM1_HUMAN
A:
[26-509]
-------------------------------------------------------------------------------------------------------------------------------
A
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
T
L
R
F
K
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
H
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
D
G
S
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
R
E
V
K
S
I
T
I
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
K
A
R
A
L
G
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
S
G
K
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
A
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
----------------------------------
Q
A
P
V
Q
G
E
D
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
I
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
N
I
H
--
7
PsiBlast_PDB
92.13
99%
-97
- C1 -
-
5FMH
1
AIFM1_HUMAN
A:
[25-510]
-------------------------------------------------------------------------------------------------------------------------------
A
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
T
L
R
F
K
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
H
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
D
G
S
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
R
E
V
K
S
I
T
I
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
K
A
R
A
L
G
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
S
G
K
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
A
A
V
G
L
E
P
N
V
K
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
K
S
A
T
E
Q
S
G
T
G
I
R
S
E
S
E
T
E
S
E
A
S
E
I
T
I
P
P
--------------
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
I
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
N
I
H
E
D
13
PsiBlast_PDB
92.12
93%
-111
- C1 -
-
5MIU
1
AIFM1_MOUSE
A:
[52-533]
---------------------------------------------------------------------------------------------------------------------------------
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
T
L
Q
F
R
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
N
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
H
L
D
V
R
G
N
M
V
K
L
N
D
G
S
Q
I
T
F
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
A
L
E
K
I
S
R
E
V
K
S
I
T
V
I
G
E
G
F
L
G
S
E
L
A
C
A
L
G
R
K
S
Q
A
S
G
I
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
Q
Y
L
S
N
W
T
M
E
K
V
K
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
G
G
R
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
T
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
K
S
A
T
E
Q
S
G
T
G
I
R
-----------------------------
D
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
V
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
N
I
H
--
10
PsiBlast_PDB
91.48
100%
-102
- C1 -
-
1M6I
1
AIFM1_HUMAN
A:
[8-488]
-------------------------------------------------------------------------------------------------------------------------------
A
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
--
P
N
V
T
K
T
L
R
F
K
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
H
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
D
G
S
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
R
E
V
K
S
I
T
I
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
K
A
R
A
L
G
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
S
G
K
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
A
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
K
S
A
T
E
Q
S
G
T
G
I
R
S
E
S
E
T
E
S
E
A
S
--------------------
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
I
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
-----
21
Fugue
90.80
99%
-100
- C1 -
-
1M6I
1
AIFM1_HUMAN
A:
[8-488]
-------------------------------------------------------------------------------------------------------------------------------
A
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
--
F
S
P
N
V
T
K
T
L
R
F
K
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
H
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
D
G
S
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
R
E
V
K
S
I
T
I
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
K
A
R
A
L
G
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
S
G
K
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
A
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
K
S
A
T
E
Q
S
G
T
G
I
R
S
E
S
E
T
E
S
E
--------------------
A
S
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
I
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
-----
12
PsiBlast_PDB
90.34
93%
-100
- C1 -
-
3GD3
1
AIFM1_MOUSE
A:
[51-533]
--------------------------------------------------------------------------------------------------------------------------------
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
T
L
Q
F
R
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
N
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
H
L
D
V
R
G
N
M
V
K
L
N
D
G
S
Q
I
T
F
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
A
L
E
K
I
S
R
E
V
K
S
I
T
V
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
K
S
Q
A
S
G
I
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
Q
Y
L
S
N
W
T
M
E
K
V
K
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
G
G
R
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
T
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
K
S
A
T
E
Q
S
G
T
G
I
R
S
E
S
E
T
E
S
E
A
--------------------
D
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
V
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
N
I
H
--
15
PsiBlast_PDB
90.11
93%
-121
- C1 -
-
3GD4
2
AIFM1_MOUSE
A:
[27-509]
--------------------------------------------------------------------------------------------------------------------------------
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
T
L
Q
F
R
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
N
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
H
L
D
V
R
G
N
M
V
K
L
N
D
G
S
Q
I
T
F
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
A
L
E
K
I
S
R
E
V
K
S
I
T
V
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
K
S
Q
A
S
G
I
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
Q
Y
L
S
N
W
T
M
E
K
V
K
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
G
G
R
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
T
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
-------------------------
E
A
S
E
I
T
I
P
-------------
E
D
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
V
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
N
I
H
--
14
PsiBlast_PDB
90.08
93%
-120
- C1 -
-
5MIV
2
AIFM1_MOUSE
A:
[51-534]
--------------------------------------------------------------------------------------------------------------------------------
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
T
L
Q
F
R
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
N
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
H
L
D
V
R
G
N
M
V
K
L
N
D
G
S
Q
I
T
F
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
A
L
E
K
I
S
R
E
V
K
S
I
T
V
I
G
E
G
F
L
G
S
E
L
A
C
A
L
G
R
K
S
Q
A
S
G
I
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
Q
Y
L
S
N
W
T
M
E
K
V
K
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
G
G
R
L
L
I
K
L
K
D
G
R
K
V
E
T
D
H
I
V
T
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
-----------------------------
E
I
T
I
P
-------------
E
D
Y
G
K
G
V
I
F
Y
L
R
D
K
V
V
V
G
I
V
L
W
N
V
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
N
I
H
E
-
38
HHSearch
51.88
22%
-98
- C1 -
-
3EF6
8
TODA_PSEP1
A:
[3-388]
-----------------------------------------------------------------------------------------------------------------------------------
T
H
V
A
I
I
G
N
G
V
G
G
F
T
T
A
Q
A
L
R
A
E
G
F
E
G
R
I
S
L
I
G
D
E
P
H
L
P
Y
D
R
P
S
L
S
K
A
V
L
D
G
S
L
E
---------------
R
P
P
I
L
A
E
A
D
W
Y
---------
G
E
A
R
I
D
M
L
T
G
P
E
V
T
A
L
D
V
Q
T
R
T
I
S
L
D
D
G
T
T
L
S
A
D
A
I
V
I
A
T
G
S
R
A
R
T
M
A
L
P
G
S
Q
L
----
P
G
V
V
T
L
R
T
Y
G
D
V
Q
V
L
R
D
S
W
T
S
A
T
R
L
L
I
V
G
G
G
L
I
G
C
E
V
A
T
T
A
R
K
L
----
G
L
S
V
T
I
L
E
A
G
D
E
L
L
V
R
V
L
G
R
R
I
G
A
W
L
R
G
L
L
T
E
L
G
V
Q
V
E
L
G
T
G
V
V
G
F
S
G
E
G
Q
L
E
Q
V
M
A
S
D
G
R
S
F
V
A
D
S
A
L
I
C
V
G
A
E
P
A
D
Q
L
A
R
Q
A
G
L
A
C
D
---
R
G
V
I
V
D
H
C
G
A
T
L
A
K
G
V
F
A
V
G
D
V
A
S
W
P
L
R
A
G
G
R
R
S
L
E
T
Y
M
N
A
Q
R
Q
A
A
A
V
A
A
A
I
L
G
K
N
V
S
A
P
Q
L
P
V
S
W
T
E
I
A
-----------
G
H
R
M
Q
M
A
G
D
I
E
G
P
G
D
F
V
----------------------------
S
-------
R
G
M
P
G
S
G
A
A
---
L
L
F
R
L
Q
E
R
R
I
Q
A
V
V
A
V
D
A
P
R
D
F
A
L
A
T
R
L
V
E
A
R
A
A
I
E
P
-------------