@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AP2A1_HUMAN: (2018-07-12 )
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHCIANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLLNDQHMGVVTAAVSLITCLCKKNPDDFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFETISLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINALKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAEKYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDDVQGYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRALLLSTYIKFINLFPETKATIQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPERESSILAKLKRKKGPGAGSALDDGRRDPSSNDINGGMEPTPSTVSTPSPSADLLGLRAAPPPAAPPASAGAGNLLVDVFDGPAAQPSLGPTPEEAFLSELEPPAPESPMALLADPAPAADPGPEDIGPPIPEADELLNKFVCKNNGVLFENQLLQIGVKSEFRQNLGRMYLFYGNKTSVQFQNFSPTVVHPGDLQTQLAVQTKRVAAQVDGGAQVQQVLNIECLRDFLTPPLLSVRFRYGGAPQALTLKLPVTINKFFQPTEMAAQDFFQRWKQLSLPQQEAQKIFKANHPMDAEVTKAKLLGFGSALLDNVDPNPENFVGAGIIQTKALQVGCLLRLEPNAQAQMYRLTLRTSKEPVSRHLCELLAQQF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220-.---........230.......240..-.....250.......260.......270.......280.......290.......300.......310.......320------....--------.....330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......-510...-------.-------...520..------.....530.........540.......550..-.....560...-....570-.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPAVSKGDG
M
R
G
L
A
V
F
I
S
D
I
R
N
CK
S
K
E
A
E
I
K
R
I
N
K
E
L
A
N
I
R
S
K
FKGDKALDGY
S
K
K
K
Y
V
C
K
L
L
F
I
F
L
LGHDIDF
G
H
M
E
A
V
N
L
LSSNKY
T
E
K
Q
I
G
Y
L
F
I
S
V
L
VNS
N
S
E
L
I
R
L
I
N
N
A
I
K
N
D
LASRNP
T
F
M
C
L
A
L
H
C
I
A
N
VG
S
R
E
M
G
E
A
F
A
A
DI
P
R
I
L
VAGD
S
M
D
S
V
K
Q
S
A
A
L
C
L
L
R
L
YKASPDLVP
M
G
E
W
T
A
R
V
V
H
L
LNDQH
M
G
V
V
T
A
A
V
S
L
I
T
C
L
CKKN
P
D
---
D
---
F
K
T
C
V
S
L
A
V
S
R
L
S
R
I
V
S
S
ASTDL-Q
D
Y
T
Y
Y
F
VPA
P
W
L
S
V
K
L
L
R
L
L
QCYPPPE
D
A
A
V
K
G
R
L
V
E
C
L
E
T
V
L
N
KAQEPPKSKKVQHSNAKN
A
I
L
F
E
T
I
S
L
I
I
H
Y--------DSEP--------
N
L
L
V
R
A
C
N
Q
L
G
Q
F
L
Q
H
RETN
L
R
Y
L
A
L
E
S
M
C
T
L
ASSEF
S
H
E
A
V
K
T
H
I
D
T
V
I
N
A
L
KTER
D
V
S
V
R
Q
R
A
A
D
L
L
Y
A
M
CDRS
N
A
K
Q
I
V
S
E
M
L
R
Y
L
E
TA
D
Y
A
I
R
E
E
I
V
L
K
V
A
I
L
A
E
K
YAVD
Y
S
W
Y
V
D
T
I
L
N
L
I
R
I
A
G
D
YV
S
E
E
V
W
Y
R
V
L
Q
I
VTN
R
D
D
V
Q
G
Y
A
A
K
T
V
F
E
A
L
QAPA
C
H
E
N
M
V
K
V
G
G
Y
I
L
G
EF
G
N
-LIAGDP-------R-------SSP
P
V
Q
F
S
------
L
L
H
S
K
F
--
H
L
C
S
V
A
T
R
A
L
L
L
S
T
Y
I
K
F
I
N
LFPE-
T
K
A
T
I
Q
G
V
L
R
A-
G
S
QLRNA-
D
V
E
L
Q
Q
R
A
V
E
Y
L
T
L
S
SVA
S
T
D
V
L
A
T
V
L
E
EMPPFP
E
R
E
S
S
I
L
A
K
L
K
RKKGPGAGSALDDGRRDPSSNDINGGMEPTPSTVSTPSPSA
D
L
L
GLRAAPPPAAPPASAGAG
N
L
L
V
D
VFDGPAAQPSLGPT
P
E
E
A
F
L
S
ELEPPAPESP
M
A
L
LADPAPAADP
G
P
E
DIGPPIP
E
A
D
E
L
L
N
K
F
V
CKNN
G
V
L
F
E
N
Q
L
L
QIG
V
K
S
E
F
R
Q
NLG
R
M
Y
L
F
YGNK
T
S
V
Q
FQNFS
P
T
VVHPGD
L
Q
T
Q
L
A
V
Q
T
K
R
V
A
A
QVDG
G
A
Q
V
Q
Q
V
L
N
I
E
C
L
R
D
FLTPP
L
L
S
V
R
F
RYGGAP
Q
A
L
T
L
KL
P
V
T
I
N
K
FFQ
P
T
E
M
A
A
Q
D
F
F
Q
R
W
K
QLSL
P
Q
Q
E
A
Q
K
I
F
KANHPMD
A
E
V
T
K
A
K
L
L
G
F
G
S
A
L
LDNVDPNPEN
F
V
G
A
G
I
I
Q
T
K
A
L
Q
V
G
C
L
L
R
LEPNAQ
A
Q
M
Y
R
L
T
L
RTSK
E
P
V
S
R
H
L
C
E
L
L
A
QQF
4
PsiBlast_PDB
99.45
91%
-158
- C1 -
-
2JKT
-
AP2A2_MOUSE
A:
[3-621]
--
A
V
S
K
G
D
G
M
R
G
L
A
V
F
I
S
D
I
R
N
C
K
S
K
E
A
E
I
K
R
I
N
K
E
L
A
N
I
R
S
K
F
K
G
D
K
A
L
D
G
Y
S
K
K
K
Y
V
C
K
L
L
F
I
F
L
L
G
H
D
I
D
F
G
H
M
E
A
V
N
L
L
S
S
N
R
Y
T
E
K
Q
I
G
Y
L
F
I
S
V
L
V
N
S
N
S
E
L
I
R
L
I
N
N
A
I
K
N
D
L
A
S
R
N
P
T
F
M
G
L
A
L
H
C
I
A
N
V
G
S
R
E
M
A
E
A
F
A
G
E
I
P
K
I
L
V
A
G
D
T
M
D
S
V
K
Q
S
A
A
L
C
L
L
R
L
Y
R
T
S
P
D
L
V
P
M
G
D
W
T
S
R
V
V
H
L
L
N
D
Q
H
L
G
V
V
T
A
A
T
S
L
I
T
T
L
A
Q
K
N
P
E
---
E
---
F
K
T
S
V
S
L
A
V
S
R
L
S
R
I
V
T
S
A
S
T
D
L
-
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
S
V
K
L
L
R
L
L
Q
C
Y
P
P
P
E
D
P
A
V
R
G
R
L
T
E
C
L
E
T
I
L
N
K
A
Q
E
P
P
K
S
K
K
V
Q
H
S
N
A
K
N
A
V
L
F
E
A
I
S
L
I
I
H
H
--------
D
S
E
P
--------
N
L
L
V
R
A
C
N
Q
L
G
Q
F
L
Q
H
R
E
T
N
L
R
Y
L
A
L
E
S
M
C
T
L
A
S
S
E
F
S
H
E
A
V
K
T
H
I
E
T
V
I
N
A
L
K
T
E
R
D
V
S
V
R
Q
R
A
V
D
L
L
Y
A
M
C
D
R
S
N
A
Q
Q
I
V
A
E
M
L
S
Y
L
E
T
A
D
Y
S
I
R
E
E
I
V
L
K
V
A
I
L
A
E
K
Y
A
V
D
Y
T
W
Y
V
D
T
I
L
N
L
I
R
I
A
G
D
Y
V
S
E
E
V
W
Y
R
V
I
Q
I
V
I
N
R
D
D
V
Q
G
Y
A
A
K
T
V
F
E
A
L
Q
A
P
A
C
H
E
N
L
V
K
V
G
G
Y
I
L
G
E
F
G
N
-
L
I
A
G
D
P
-------
R
-------
S
S
P
L
I
Q
F
N
------
L
L
H
S
K
F
--
H
L
C
S
V
P
T
R
A
L
L
L
S
T
Y
I
K
F
V
N
L
F
P
E
-
V
K
A
T
I
Q
D
V
L
R
S
-
D
S
Q
L
K
N
A
-
D
V
E
L
Q
Q
R
A
V
E
Y
L
R
L
S
T
V
A
S
T
D
I
L
A
T
V
L
E
E
M
P
P
F
P
E
R
E
S
S
I
L
A
K
L
K
K
K
K
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
98.78
91%
-158
- C1 -
-
2JKR
-
AP2A2_MOUSE
A:
[3-621]
--
A
V
S
K
G
D
G
M
R
G
L
A
V
F
I
S
D
I
R
N
C
K
S
K
E
A
E
I
K
R
I
N
K
E
L
A
N
I
R
S
K
F
K
G
D
K
A
L
D
G
Y
S
K
K
K
Y
V
C
K
L
L
F
I
F
L
L
G
H
D
I
D
F
G
H
M
E
A
V
N
L
L
S
S
N
R
Y
T
E
K
Q
I
G
Y
L
F
I
S
V
L
V
N
S
N
S
E
L
I
R
L
I
N
N
A
I
K
N
D
L
A
S
R
N
P
T
F
M
G
L
A
L
H
C
I
A
N
V
G
S
R
E
M
A
E
A
F
A
G
E
I
P
K
I
L
V
A
G
D
T
M
D
S
V
K
Q
S
A
A
L
C
L
L
R
L
Y
R
T
S
P
D
L
V
P
M
G
D
W
T
S
R
V
V
H
L
L
N
D
Q
H
L
G
V
V
T
A
A
T
S
L
I
T
T
L
A
Q
K
N
P
E
---
E
---
F
K
T
S
V
S
L
A
V
S
R
L
S
R
I
V
T
S
A
S
T
D
L
-
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
S
V
K
L
L
R
L
L
Q
C
Y
P
P
P
E
D
P
A
V
R
G
R
L
T
E
C
L
E
T
I
L
N
K
A
Q
E
P
P
K
S
K
K
V
Q
H
S
N
A
K
N
A
V
L
F
E
A
I
S
L
I
I
H
H
--------
D
S
E
P
--------
N
L
L
V
R
A
C
N
Q
L
G
Q
F
L
Q
H
R
E
T
N
L
R
Y
L
A
L
E
S
M
C
T
L
A
S
S
E
F
S
H
E
A
V
K
T
H
I
E
T
V
I
N
A
L
K
T
E
R
D
V
S
V
R
Q
R
A
V
D
L
L
Y
A
M
C
D
R
S
N
A
Q
Q
I
V
A
E
M
L
S
Y
L
E
T
A
D
Y
S
I
R
E
E
I
V
L
K
V
A
I
L
A
E
K
Y
A
V
D
Y
T
W
Y
V
D
T
I
L
N
L
I
R
I
A
G
D
Y
V
S
E
E
V
W
Y
R
V
I
Q
I
V
I
N
R
D
D
V
Q
G
Y
A
A
K
T
V
F
E
A
L
Q
A
P
A
C
H
E
N
L
V
K
V
G
G
Y
I
L
G
E
F
G
N
-
L
I
A
G
D
P
-------
R
-------
S
S
P
L
I
Q
F
N
------
L
L
H
S
K
F
--
H
L
C
S
V
P
T
R
A
L
L
L
S
T
Y
I
K
F
V
N
L
F
P
E
-
V
K
A
T
I
Q
D
V
L
R
S
-
D
S
Q
L
K
N
A
-
D
V
E
L
Q
Q
R
A
V
E
Y
L
R
L
S
T
V
A
S
T
D
I
L
A
T
V
L
E
E
M
P
P
F
P
E
R
E
S
S
I
L
A
K
L
K
K
K
K
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
98.76
92%
-158
- C1 -
-
2JKR
-
AP2A2_MOUSE
A:
[3-617]
--
A
V
S
K
G
D
G
M
R
G
L
A
V
F
I
S
D
I
R
N
C
K
S
K
E
A
E
I
K
R
I
N
K
E
L
A
N
I
R
S
K
F
K
G
D
K
A
L
D
G
Y
S
K
K
K
Y
V
C
K
L
L
F
I
F
L
L
G
H
D
I
D
F
G
H
M
E
A
V
N
L
L
S
S
N
R
Y
T
E
K
Q
I
G
Y
L
F
I
S
V
L
V
N
S
N
S
E
L
I
R
L
I
N
N
A
I
K
N
D
L
A
S
R
N
P
T
F
M
G
L
A
L
H
C
I
A
N
V
G
S
R
E
M
A
E
A
F
A
G
E
I
P
K
I
L
V
A
G
D
T
M
D
S
V
K
Q
S
A
A
L
C
L
L
R
L
Y
R
T
S
P
D
L
V
P
M
G
D
W
T
S
R
V
V
H
L
L
N
D
Q
H
L
G
V
V
T
A
A
T
S
L
I
T
T
L
A
Q
K
N
P
E
---
E
---
F
K
T
S
V
S
L
A
V
S
R
L
S
R
I
V
T
S
A
S
T
D
L
-
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
S
V
K
L
L
R
L
L
Q
C
Y
P
P
P
E
D
P
A
V
R
G
R
L
T
E
C
L
E
T
I
L
N
K
A
Q
E
P
P
K
S
K
K
V
Q
H
S
N
A
K
N
A
V
L
F
E
A
I
S
L
I
I
H
H
--------
D
S
E
P
--------
N
L
L
V
R
A
C
N
Q
L
G
Q
F
L
Q
H
R
E
T
N
L
R
Y
L
A
L
E
S
M
C
T
L
A
S
S
E
F
S
H
E
A
V
K
T
H
I
E
T
V
I
N
A
L
K
T
E
R
D
V
S
V
R
Q
R
A
V
D
L
L
Y
A
M
C
D
R
S
N
A
Q
Q
I
V
A
E
M
L
S
Y
L
E
T
A
D
Y
S
I
R
E
E
I
V
L
K
V
A
I
L
A
E
K
Y
A
V
D
Y
T
W
Y
V
D
T
I
L
N
L
I
R
I
A
G
D
Y
V
S
E
E
V
W
Y
R
V
I
Q
I
V
I
N
R
D
D
V
Q
G
Y
A
A
K
T
V
F
E
A
L
Q
A
P
A
C
H
E
N
L
V
K
V
G
G
Y
I
L
G
E
F
G
N
-
L
I
A
G
D
P
-------
R
-------
S
S
P
L
I
Q
F
N
------
L
L
H
S
K
F
--
H
L
C
S
V
P
T
R
A
L
L
L
S
T
Y
I
K
F
V
N
L
F
P
E
-
V
K
A
T
I
Q
D
V
L
R
S
-
D
S
Q
L
K
N
A
-
D
V
E
L
Q
Q
R
A
V
E
Y
L
R
L
S
T
V
A
S
T
D
I
L
A
T
V
L
E
E
M
P
P
F
P
E
R
E
S
S
I
L
A
K
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
97.26
91%
-158
- C1 -
-
4UQI
1
AP2A2_RAT
A:
[9-608]
--------
G
M
R
G
L
A
V
F
I
S
D
I
R
N
C
K
S
K
E
A
E
I
K
R
I
N
K
E
L
A
N
I
R
S
K
F
K
G
D
K
A
L
D
G
Y
S
K
K
K
Y
V
C
K
L
L
F
I
F
L
L
G
H
D
I
D
F
G
H
M
E
A
V
N
L
L
S
S
N
R
Y
T
E
K
Q
I
G
Y
L
F
I
S
V
L
V
N
S
N
S
E
L
I
R
L
I
N
N
A
I
K
N
D
L
A
S
R
N
P
T
F
M
G
L
A
L
H
C
I
A
N
V
G
S
R
E
M
A
E
A
F
A
G
E
I
P
K
I
L
V
A
G
D
T
M
D
S
V
K
Q
S
A
A
L
C
L
L
R
L
Y
R
T
S
P
D
L
V
P
M
G
D
W
T
S
R
V
V
H
L
L
N
D
Q
H
L
G
V
V
T
A
A
T
S
L
I
T
T
L
A
Q
K
N
P
E
---
E
---
F
K
T
S
V
S
L
A
V
S
R
L
S
R
I
V
T
S
A
S
T
D
L
-
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
S
V
K
L
L
R
L
L
Q
C
Y
P
P
P
E
D
P
A
V
R
G
R
L
T
E
C
L
E
T
I
L
N
K
A
Q
E
P
P
K
S
K
K
V
Q
H
S
N
A
K
N
A
V
L
F
E
A
I
S
L
I
I
H
H
--------
D
S
E
P
--------
N
L
L
V
R
A
C
N
Q
L
G
Q
F
L
Q
H
R
E
T
N
L
R
Y
L
A
L
E
S
M
C
T
L
A
S
S
E
F
S
H
E
A
V
K
T
H
I
E
T
V
I
N
A
L
K
T
E
R
D
V
S
V
R
Q
R
A
V
D
L
L
Y
A
M
C
D
R
S
N
A
Q
Q
I
V
A
E
M
L
S
Y
L
E
T
A
D
Y
S
I
R
E
E
I
V
L
K
V
A
I
L
A
E
K
Y
A
V
D
Y
T
W
Y
V
D
T
I
L
N
L
I
R
I
A
G
D
Y
V
S
E
E
V
W
Y
R
V
I
Q
I
V
I
N
R
D
D
V
Q
G
Y
A
A
K
T
V
F
E
A
L
Q
A
P
A
C
H
E
N
L
V
K
V
G
G
Y
I
L
G
E
F
G
N
-
L
I
A
G
D
P
-------
R
-------
S
S
P
L
I
Q
F
N
------
L
L
H
S
K
F
--
H
L
C
S
V
P
T
R
A
L
L
L
S
T
Y
I
K
F
V
N
L
F
P
E
-
V
K
A
T
I
Q
D
V
L
R
S
-
D
S
Q
L
K
N
A
-
D
V
E
L
Q
Q
R
A
V
E
Y
L
R
L
S
T
V
A
S
T
D
I
L
A
T
V
L
E
E
M
P
P
F
P
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
95.08
92%
-153
- C1 -
-
2VGL
1
AP2A2_RAT
A:
[9-608]
--------
G
M
R
G
L
A
V
F
I
S
D
I
R
N
C
K
S
K
E
A
E
I
K
R
I
N
K
E
L
A
N
I
R
S
K
F
K
G
D
K
A
L
D
G
Y
S
K
K
K
Y
V
C
K
L
L
F
I
F
L
L
G
H
D
I
D
F
G
H
M
E
A
V
N
L
L
S
S
N
R
Y
T
E
K
Q
I
G
Y
L
F
I
S
V
L
V
N
S
N
S
E
L
I
R
L
I
N
N
A
I
K
N
D
L
A
S
R
N
P
T
F
M
G
L
A
L
H
C
I
A
N
V
G
S
R
E
M
A
E
A
F
A
G
E
I
P
K
I
L
V
A
G
D
T
M
D
S
V
K
Q
S
A
A
L
C
L
L
R
L
Y
R
T
S
P
D
L
V
P
M
G
D
W
T
S
R
V
V
H
L
L
N
D
Q
H
L
G
V
V
T
A
A
T
S
L
I
T
T
L
A
Q
K
N
P
E
---
E
---
F
K
T
S
V
S
L
A
V
S
R
L
S
R
I
V
T
S
A
S
T
D
L
-
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
S
V
K
L
L
R
L
L
Q
C
Y
P
P
P
E
D
P
A
V
R
G
R
L
T
E
C
L
E
T
I
L
N
K
A
Q
E
P
P
K
S
K
K
V
Q
H
S
N
A
K
N
A
V
L
F
E
A
I
S
L
I
I
H
H
--------
D
S
E
P
--------
N
L
L
V
R
A
C
N
Q
L
G
Q
F
L
Q
H
R
E
T
N
L
R
Y
L
A
L
E
S
M
C
T
L
A
S
S
E
F
S
H
E
A
V
K
T
H
I
E
T
V
I
N
A
L
K
T
E
R
D
V
S
V
R
Q
R
A
V
D
L
L
Y
A
M
C
D
R
S
N
A
Q
Q
I
V
A
E
M
L
S
Y
L
E
T
A
D
Y
S
I
R
E
E
I
V
L
K
V
A
I
L
A
E
K
Y
A
V
D
Y
T
W
Y
V
D
T
I
L
N
L
I
R
I
A
G
D
Y
V
S
E
E
V
W
Y
R
V
I
Q
I
V
I
N
R
D
D
V
Q
G
Y
A
A
K
T
V
F
E
A
L
Q
A
P
A
C
H
E
N
L
V
K
V
G
G
Y
I
L
G
E
F
G
N
-
L
I
A
G
D
P
-------
R
-------
S
S
P
L
I
Q
F
N
------
L
L
H
S
K
F
--
H
L
C
S
V
P
T
R
A
L
L
L
S
T
Y
I
K
F
V
N
L
F
P
E
-
V
K
A
T
I
Q
D
V
L
R
S
-
D
S
Q
L
K
N
A
-
D
V
E
L
Q
Q
R
A
V
E
Y
L
R
L
S
T
V
A
S
T
D
I
L
A
T
V
L
E
E
M
P
P
F
P
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
94.85
91%
-153
- C1 -
-
2VGL
1
AP2A2_RAT
A:
[9-608]
--------
G
M
R
G
L
A
V
F
I
S
D
I
R
N
C
K
S
K
E
A
E
I
K
R
I
N
K
E
L
A
N
I
R
S
K
F
K
G
D
K
A
L
D
G
Y
S
K
K
K
Y
V
C
K
L
L
F
I
F
L
L
G
H
D
I
D
F
G
H
M
E
A
V
N
L
L
S
S
N
R
Y
T
E
K
Q
I
G
Y
L
F
I
S
V
L
V
N
S
N
S
E
L
I
R
L
I
N
N
A
I
K
N
D
L
A
S
R
N
P
T
F
M
G
L
A
L
H
C
I
A
N
V
G
S
R
E
M
A
E
A
F
A
G
E
I
P
K
I
L
V
A
G
D
T
M
D
S
V
K
Q
S
A
A
L
C
L
L
R
L
Y
R
T
S
P
D
L
V
P
M
G
D
W
T
S
R
V
V
H
L
L
N
D
Q
H
L
G
V
V
T
A
A
T
S
L
I
T
T
L
A
Q
K
N
P
E
---
E
---
F
K
T
S
V
S
L
A
V
S
R
L
S
R
I
V
T
S
A
S
T
D
L
-
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
S
V
K
L
L
R
L
L
Q
C
Y
P
P
P
E
D
P
A
V
R
G
R
L
T
E
C
L
E
T
I
L
N
K
A
Q
E
P
P
K
S
K
K
V
Q
H
S
N
A
K
N
A
V
L
F
E
A
I
S
L
I
I
H
H
--------
D
S
E
P
--------
N
L
L
V
R
A
C
N
Q
L
G
Q
F
L
Q
H
R
E
T
N
L
R
Y
L
A
L
E
S
M
C
T
L
A
S
S
E
F
S
H
E
A
V
K
T
H
I
E
T
V
I
N
A
L
K
T
E
R
D
V
S
V
R
Q
R
A
V
D
L
L
Y
A
M
C
D
R
S
N
A
Q
Q
I
V
A
E
M
L
S
Y
L
E
T
A
D
Y
S
I
R
E
E
I
V
L
K
V
A
I
L
A
E
K
Y
A
V
D
Y
T
W
Y
V
D
T
I
L
N
L
I
R
I
A
G
D
Y
V
S
E
E
V
W
Y
R
V
I
Q
I
V
I
N
R
D
D
V
Q
G
Y
A
A
K
T
V
F
E
A
L
Q
A
P
A
C
H
E
N
L
V
K
V
G
G
Y
I
L
G
E
F
G
N
-
L
I
A
G
D
P
-------
R
-------
S
S
P
L
I
Q
F
N
------
L
L
H
S
K
F
--
H
L
C
S
V
P
T
R
A
L
L
L
S
T
Y
I
K
F
V
N
L
F
P
E
-
V
K
A
T
I
Q
D
V
L
R
S
-
D
S
Q
L
K
N
A
-
D
V
E
L
Q
Q
R
A
V
E
Y
L
R
L
S
T
V
A
S
T
D
I
L
A
T
V
L
E
E
M
P
P
F
P
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.12
91%
-147
- C1 -
-
2XA7
-
AP2A2_RAT
A:
[9-621]
--------
G
M
R
G
L
A
V
F
I
S
D
I
R
N
C
K
S
K
E
A
E
I
K
R
I
N
K
E
L
A
N
I
R
S
K
F
K
G
D
K
A
L
D
G
Y
S
K
K
K
Y
V
C
K
L
L
F
I
F
L
L
G
H
D
I
D
F
G
H
M
E
A
V
N
L
L
S
S
N
R
Y
T
E
K
Q
I
G
Y
L
F
I
S
V
L
V
N
S
N
S
E
L
I
R
L
I
N
N
A
I
K
N
D
L
A
S
R
N
P
T
F
M
G
L
A
L
H
C
I
A
N
V
G
S
R
E
M
A
E
A
F
A
G
E
I
P
K
I
L
V
A
G
D
T
M
D
S
V
K
Q
S
A
A
L
C
L
L
R
L
Y
R
T
S
P
D
L
V
P
M
G
D
W
T
S
R
V
V
H
L
L
N
D
Q
H
L
G
V
V
T
A
A
T
S
L
I
T
T
L
A
Q
K
N
P
E
---
E
---
F
K
T
S
V
S
L
A
V
S
R
L
S
R
I
V
T
S
A
S
T
D
L
-
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
S
V
K
L
L
R
L
L
Q
C
Y
P
P
P
E
D
P
A
V
R
G
R
L
T
E
C
L
E
T
I
L
N
K
A
Q
E
P
P
K
S
K
K
V
Q
H
S
N
A
K
N
A
V
L
F
E
A
I
S
L
I
I
H
H
--------
D
S
E
P
--------
N
L
L
V
R
A
C
N
Q
L
G
Q
F
L
Q
H
R
E
T
N
L
R
Y
L
A
L
E
S
M
C
T
L
A
S
S
E
F
S
H
E
A
V
K
T
H
I
E
T
V
I
N
A
L
K
T
E
R
D
V
S
V
R
Q
R
A
V
D
L
L
Y
A
M
C
D
R
S
N
A
Q
Q
I
V
A
E
M
L
S
Y
L
E
T
A
D
Y
S
I
R
E
E
I
V
L
K
V
A
I
L
A
E
K
Y
A
V
D
Y
T
W
Y
V
D
T
I
L
N
L
I
R
I
A
G
D
Y
V
S
E
E
V
W
Y
R
V
I
Q
I
V
I
N
R
D
D
V
Q
G
Y
A
A
K
T
V
F
E
A
L
Q
A
P
A
C
H
E
N
L
V
K
V
G
G
Y
I
L
G
E
F
G
N
-
L
I
A
G
D
P
-------
R
-------
S
S
P
L
I
Q
F
N
------
L
L
H
S
K
F
--
H
L
C
S
V
P
T
R
A
L
L
L
S
T
Y
I
K
F
V
N
L
F
P
E
-
V
K
A
T
I
Q
D
V
L
R
S
-
D
S
Q
L
K
N
A
-
D
V
E
L
Q
Q
R
A
V
E
Y
L
R
L
S
T
V
A
S
T
D
I
L
A
T
V
L
E
E
M
P
P
F
P
E
R
E
S
S
I
L
A
K
L
K
K
K
K
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
64.69
30%
-70
- C1 -
-
4HMY
-
AP1G1_MOUSE
A:
[7-585]
------------
L
R
E
L
I
R
T
I
R
T
A
R
T
Q
A
E
E
R
E
M
I
Q
K
E
C
A
A
I
R
S
S
F
R
E
E
---
D
N
T
Y
R
C
R
N
V
A
K
L
L
Y
M
H
M
L
G
Y
P
A
H
F
G
Q
L
E
C
L
K
L
I
A
S
Q
K
F
T
D
K
R
I
G
Y
L
G
A
M
L
L
L
D
E
R
Q
D
V
H
L
L
M
T
N
C
I
K
N
D
L
N
H
S
T
Q
F
V
Q
G
L
A
L
C
T
L
G
C
M
G
S
S
E
M
C
R
D
L
A
G
E
V
E
K
L
L
--
K
T
S
N
S
Y
L
R
K
K
A
A
L
C
A
V
H
V
I
R
K
V
P
E
L
M
--
E
M
F
L
P
A
T
K
N
L
L
N
E
K
N
H
G
V
L
H
T
S
V
V
L
L
T
E
M
C
E
R
S
P
D
---
M
L
A
H
F
R
K
L
V
P
Q
L
V
R
I
L
K
N
L
I
M
S
--
G
Y
S
-
P
E
H
D
V
S
G
I
S
D
P
F
L
Q
V
R
I
L
R
L
L
R
I
L
G
R
N
D
D
-
D
S
S
E
A
M
N
D
I
L
A
Q
V
A
T
N
T
E
T
--------
S
K
N
V
G
N
A
I
L
Y
E
T
V
L
T
I
M
D
I
--------
K
S
E
S
--------
G
L
R
V
L
A
I
N
I
L
G
R
F
L
L
N
N
D
K
N
I
R
Y
V
A
L
T
S
L
L
K
T
V
Q
T
--
D
H
N
A
V
Q
R
H
R
S
T
I
V
D
C
L
K
-
D
L
D
V
S
I
K
R
R
A
M
E
L
S
F
A
L
V
N
G
N
N
I
R
G
M
M
K
E
L
L
Y
F
L
D
S
C
E
P
E
F
K
A
D
C
A
S
G
I
F
L
A
A
E
K
Y
A
P
S
K
R
W
H
I
D
T
I
M
R
V
L
T
T
A
G
S
Y
V
R
D
D
A
V
P
N
L
I
Q
L
I
T
N
S
V
E
M
H
A
Y
T
V
Q
R
L
Y
K
A
I
L
G
D
Y
S
Q
Q
P
L
V
Q
V
A
A
W
C
I
G
E
Y
G
D
-
L
L
V
S
G
Q
-------
C
EE
E
E
P
I
Q
V
T
E
D
E
V
L
D
------
I
L
E
S
V
L
IS
N
M
S
T
S
V
T
R
G
Y
A
L
T
A
I
M
K
L
S
T
R
F
T
C
-
T
V
N
R
I
K
K
V
V
S
I
-
Y
--
G
S
S
I
-
D
V
E
L
Q
Q
R
A
V
E
Y
N
A
L
F
K
K
Y
-
D
H
M
R
S
A
L
L
E
R
M
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
63.92
30%
-68
- C1 -
-
4P6Z
-
AP1G1_MOUSE
G:
[16-602]
-------
P
A
P
I
R
L
R
E
L
I
R
T
I
R
T
A
R
T
Q
A
E
E
R
E
M
I
Q
K
E
C
A
A
I
R
S
S
F
R
E
E
---
D
N
T
Y
R
C
R
N
V
A
K
L
L
Y
M
H
M
L
G
Y
P
A
H
F
G
Q
L
E
C
L
K
L
I
A
S
Q
K
F
T
D
K
R
I
G
Y
L
G
A
M
L
L
L
D
E
R
Q
D
V
H
L
L
M
T
N
C
I
K
N
D
L
N
H
S
T
Q
F
V
Q
G
L
A
L
C
T
L
G
C
M
G
S
S
E
M
C
R
D
L
A
G
E
V
E
K
L
L
--
K
T
S
N
S
Y
L
R
K
K
A
A
L
C
A
V
H
V
I
R
K
V
P
E
L
M
--
E
M
F
L
P
A
T
K
N
L
L
N
E
K
N
H
G
V
L
H
T
S
V
V
L
L
T
E
M
C
E
R
S
P
D
MLA
H
---
F
R
K
L
V
P
Q
L
V
R
I
L
K
N
L
I
M
S
--
G
Y
S
-
P
E
H
D
V
S
G
I
S
D
P
F
L
Q
V
R
I
L
R
L
L
R
I
L
G
R
N
D
-
D
D
S
S
E
A
M
N
D
I
L
A
Q
V
A
T
N
T
E
--------
T
S
K
N
V
G
N
A
I
L
Y
E
T
V
L
T
I
M
D
I
--------
K
S
E
S
--------
G
L
R
V
L
A
I
N
I
L
G
R
F
L
L
N
N
D
K
N
I
R
Y
V
A
L
T
S
L
L
K
T
V
Q
T
--
D
H
N
A
V
Q
R
H
R
S
T
I
V
D
C
L
K
-
D
L
D
V
S
I
K
R
R
A
M
E
L
S
F
A
L
V
N
G
N
N
I
R
G
M
M
K
E
L
L
Y
F
L
D
S
C
E
P
E
F
K
A
D
C
A
S
G
I
F
L
A
A
E
K
Y
A
P
S
K
R
W
H
I
D
T
I
M
R
V
L
T
T
A
G
S
Y
V
R
D
D
A
V
P
N
L
I
Q
L
I
T
N
S
V
E
M
H
A
Y
T
V
Q
R
L
Y
K
A
I
L
G
D
Y
S
Q
Q
P
L
V
Q
V
A
A
W
C
I
G
E
Y
G
D
-
L
L
V
S
G
Q
CEEEE--
P
IQ-----
V
T
E
D
E
V
L
D
------
I
L
E
S
V
L
IS
N
M
S
T
S
V
T
R
G
Y
A
L
T
A
I
M
K
L
S
T
R
F
T
C
-
T
V
N
R
I
K
K
V
V
S
I
-
Y
--
G
S
S
I
-
D
V
E
L
Q
Q
R
A
V
E
Y
N
A
L
F
K
K
Y
-
D
H
M
R
S
A
L
L
E
R
M
P
V
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
63.61
29%
-76
- C1 -
-
1W63
-
AP1G1_MOUSE
A:
[1-589]
------
M
P
A
P
I
R
L
R
E
L
I
R
T
I
R
T
A
R
T
Q
A
E
E
R
E
M
I
Q
K
E
C
A
A
I
R
S
S
F
R
E
E
D
N
---
T
Y
R
C
R
N
V
A
K
L
L
Y
M
H
M
L
G
Y
P
A
H
F
G
Q
L
E
C
L
K
L
I
A
S
Q
K
F
T
D
K
R
I
G
Y
L
G
A
M
L
L
L
D
E
R
Q
D
V
H
L
L
M
T
N
C
I
K
N
D
L
N
H
S
T
Q
F
V
Q
G
L
A
L
C
T
L
G
C
M
G
S
S
E
M
C
R
D
L
A
G
E
V
E
K
L
L
K
--
T
S
N
S
Y
L
R
K
K
A
A
L
C
A
V
H
V
I
R
K
V
P
E
L
M
E
--
M
F
L
P
A
T
K
N
L
L
N
E
K
N
H
G
V
L
H
T
S
V
V
L
L
T
E
M
C
E
R
S
P
D
---
M
---
L
A
H
F
R
K
L
V
P
Q
L
V
R
I
L
K
N
L
I
M
S
G
Y
S
P
E
H
D
V
S
G
I
S
D
P
F
L
Q
V
R
I
L
R
L
L
R
I
L
G
R
N
D
D
D
S
S
E
-
A
M
N
D
I
L
A
Q
V
A
T
N
T
E
T
S
K
--------
N
V
G
N
A
I
L
Y
E
T
V
L
T
I
M
D
I
--------
K
S
E
S
--------
G
L
R
V
L
A
I
N
I
L
G
R
F
L
L
N
N
D
K
N
I
R
Y
V
A
L
T
S
L
L
K
T
V
Q
T
D
--
H
N
A
V
Q
R
H
R
S
T
I
V
D
C
L
K
D
L
-
D
V
S
I
K
R
R
A
M
E
L
S
F
A
L
V
N
G
N
N
I
R
G
M
M
K
E
L
L
Y
F
L
D
S
C
E
P
E
F
K
A
D
C
A
S
G
I
F
L
A
A
E
K
Y
A
P
S
K
R
W
H
I
D
T
I
M
R
V
L
T
T
A
G
S
Y
V
R
D
D
A
V
P
N
L
I
Q
L
I
T
N
S
V
E
M
H
A
Y
T
V
Q
R
L
Y
K
A
I
L
G
D
Y
S
Q
Q
P
L
V
Q
V
A
A
W
C
I
G
E
Y
G
D
-
L
L
V
S
G
Q
CEE
E
E
P
I
Q
-------
V
T
E
D
E
V
L
D
------
I
L
E
S
V
L
I
S
N
M
S
T
S
V
T
R
G
Y
A
L
T
A
I
M
K
L
S
T
R
F
T
C
-
T
V
N
R
I
K
K
V
V
S
I
-
Y
G
S
--
S
I
-
D
V
E
L
Q
Q
R
A
V
E
Y
N
A
L
F
K
-
K
Y
D
H
M
R
S
A
L
L
E
R
M
P
V
M
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
62.65
30%
-71
- C1 -
-
1W63
-
AP1G1_MOUSE
A:
[10-589]
---------------
L
I
R
T
I
R
T
A
R
T
Q
A
E
E
R
E
M
I
Q
K
E
C
A
A
I
R
S
S
F
R
E
E
---
D
N
T
Y
R
C
R
N
V
A
K
L
L
Y
M
H
M
L
G
Y
P
A
H
F
G
Q
L
E
C
L
K
L
I
A
S
Q
K
F
T
D
K
R
I
G
Y
L
G
A
M
L
L
L
D
E
R
Q
D
V
H
L
L
M
T
N
C
I
K
N
D
L
N
H
S
T
Q
F
V
Q
G
L
A
L
C
T
L
G
C
M
G
S
S
E
M
C
R
D
L
A
G
E
V
E
K
L
L
K
T
S
N
S
Y
--
L
R
K
K
A
A
L
C
A
V
H
V
I
R
K
V
P
E
L
M
E
M
--
F
L
P
A
T
K
N
L
L
N
E
K
N
H
G
V
L
H
T
S
V
V
L
L
T
E
M
C
E
R
S
P
D
M
L
A
H
---
F
R
K
L
V
P
Q
L
V
R
I
L
K
N
L
I
M
S
G
Y
S
P
E
-
H
D
V
S
--
G
I
S
D
P
F
L
Q
V
R
I
L
R
L
L
R
I
L
G
R
N
D
D
D
S
S
-----
E
A
M
N
D
I
L
A
Q
V
A
T
N
T
E
T
S
K
----
N
V
G
N
A
I
L
Y
E
T
V
L
T
I
M
D
I
--------
K
S
E
S
--------
G
L
R
V
L
A
I
N
I
L
G
R
F
L
L
N
N
D
K
N
I
R
Y
V
A
L
T
S
L
--
L
K
T
V
Q
T
D
H
N
A
V
Q
R
H
R
S
T
I
V
D
C
L
K
-
D
L
D
V
S
I
K
R
R
A
M
E
L
S
F
A
L
V
N
G
N
N
I
R
G
M
M
K
E
L
L
Y
F
L
D
S
C
E
P
E
F
K
A
D
C
A
S
G
I
F
L
A
A
E
K
Y
A
P
S
K
R
W
H
I
D
T
I
M
R
V
L
T
T
A
G
S
Y
V
R
D
D
A
V
P
N
L
I
Q
L
I
T
N
S
V
E
M
H
A
Y
T
V
Q
R
L
Y
K
A
I
L
G
D
Y
S
Q
Q
P
L
V
Q
V
A
A
W
C
I
G
E
Y
G
D
L
L
V
S
G
Q
C
-------
E
-------
E
E
E
P
I
Q
V
T
E
D
E
V
L
D
I
L
E
S
V
L
I
S
N
M
S
T
S
V
T
R
G
Y
A
L
T
A
I
M
K
L
S
T
R
F
T
C
-
T
V
N
R
I
K
K
V
V
S
I
Y
G
S
S
I
----
D
V
E
L
Q
Q
R
A
V
E
Y
N
A
L
--
F
K
K
Y
D
H
M
R
S
A
L
L
E
R
M
P
V
M
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
62.51
30%
-69
- C1 -
-
4HMY
-
AP1G1_MOUSE
A:
[10-585]
---------------
L
I
R
T
I
R
T
A
R
T
Q
A
E
E
R
E
M
I
Q
K
E
C
A
A
I
R
S
S
F
R
E
E
---
D
N
T
Y
R
C
R
N
V
A
K
L
L
Y
M
H
M
L
G
Y
P
A
H
F
G
Q
L
E
C
L
K
L
I
A
S
Q
K
F
T
D
K
R
I
G
Y
L
G
A
M
L
L
L
D
E
R
Q
D
V
H
L
L
M
T
N
C
I
K
N
D
L
N
H
S
T
Q
F
V
Q
G
L
A
L
C
T
L
G
C
M
G
S
S
E
M
C
R
D
L
A
G
E
V
E
K
L
L
K
T
S
N
S
Y
--
L
R
K
K
A
A
L
C
A
V
H
V
I
R
K
V
P
E
L
M
E
M
--
F
L
P
A
T
K
N
L
L
N
E
K
N
H
G
V
L
H
T
S
V
V
L
L
T
E
M
C
E
R
S
P
D
M
L
A
H
---
F
R
K
L
V
P
Q
L
V
R
I
L
K
N
L
I
M
S
G
Y
S
P
E
-
H
D
V
S
--
G
I
S
D
P
F
L
Q
V
R
I
L
R
L
L
R
I
L
G
R
N
D
D
D
S
S
-----
E
A
M
N
D
I
L
A
Q
V
A
T
N
T
E
T
S
K
----
N
V
G
N
A
I
L
Y
E
T
V
L
T
I
M
D
I
--------
K
S
E
S
--------
G
L
R
V
L
A
I
N
I
L
G
R
F
L
L
N
N
D
K
N
I
R
Y
V
A
L
T
S
L
--
L
K
T
V
Q
T
D
H
N
A
V
Q
R
H
R
S
T
I
V
D
C
L
K
-
D
L
D
V
S
I
K
R
R
A
M
E
L
S
F
A
L
V
N
G
N
N
I
R
G
M
M
K
E
L
L
Y
F
L
D
S
C
E
P
E
F
K
A
D
C
A
S
G
I
F
L
A
A
E
K
Y
A
P
S
K
R
W
H
I
D
T
I
M
R
V
L
T
T
A
G
S
Y
V
R
D
D
A
V
P
N
L
I
Q
L
I
T
N
S
V
E
M
H
A
Y
T
V
Q
R
L
Y
K
A
I
L
G
D
Y
S
Q
Q
P
L
V
Q
V
A
A
W
C
I
G
E
Y
G
D
L
L
V
S
G
Q
C
-------
E
-------
E
E
E
P
I
Q
V
T
E
D
E
V
L
D
I
L
E
S
V
L
IS
N
M
S
T
S
V
T
R
G
Y
A
L
T
A
I
M
K
L
S
T
R
F
T
C
-
T
V
N
R
I
K
K
V
V
S
I
Y
G
S
S
I
----
D
V
E
L
Q
Q
R
A
V
E
Y
N
A
L
--
F
K
K
Y
D
H
M
R
S
A
L
L
E
R
M
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
62.51
30%
-70
- C1 -
-
4P6Z
-
AP1G1_MOUSE
G:
[24-602]
---------------
L
I
R
T
I
R
T
A
R
T
Q
A
E
E
R
E
M
I
Q
K
E
C
A
A
I
R
S
S
F
R
E
E
---
D
N
T
Y
R
C
R
N
V
A
K
L
L
Y
M
H
M
L
G
Y
P
A
H
F
G
Q
L
E
C
L
K
L
I
A
S
Q
K
F
T
D
K
R
I
G
Y
L
G
A
M
L
L
L
D
E
R
Q
D
V
H
L
L
M
T
N
C
I
K
N
D
L
N
H
S
T
Q
F
V
Q
G
L
A
L
C
T
L
G
C
M
G
S
S
E
M
C
R
D
L
A
G
E
V
E
K
L
L
K
T
S
N
S
Y
--
L
R
K
K
A
A
L
C
A
V
H
V
I
R
K
V
P
E
L
M
E
M
--
F
L
P
A
T
K
N
L
L
N
E
K
N
H
G
V
L
H
T
S
V
V
L
L
T
E
M
C
E
R
S
P
D
MLA
H
---
F
R
K
L
V
P
Q
L
V
R
I
L
K
N
L
I
M
S
G
Y
S
P
E
-
H
D
V
S
--
G
I
S
D
P
F
L
Q
V
R
I
L
R
L
L
R
I
L
G
R
N
D
D
D
S
S
-----
E
A
M
N
D
I
L
A
Q
V
A
T
N
T
E
T
S
K
----
N
V
G
N
A
I
L
Y
E
T
V
L
T
I
M
D
I
--------
K
S
E
S
--------
G
L
R
V
L
A
I
N
I
L
G
R
F
L
L
N
N
D
K
N
I
R
Y
V
A
L
T
S
L
--
L
K
T
V
Q
T
D
H
N
A
V
Q
R
H
R
S
T
I
V
D
C
L
K
-
D
L
D
V
S
I
K
R
R
A
M
E
L
S
F
A
L
V
N
G
N
N
I
R
G
M
M
K
E
L
L
Y
F
L
D
S
C
E
P
E
F
K
A
D
C
A
S
G
I
F
L
A
A
E
K
Y
A
P
S
K
R
W
H
I
D
T
I
M
R
V
L
T
T
A
G
S
Y
V
R
D
D
A
V
P
N
L
I
Q
L
I
T
N
S
V
E
M
H
A
Y
T
V
Q
R
L
Y
K
A
I
L
G
D
Y
S
Q
Q
P
L
V
Q
V
A
A
W
C
I
G
E
Y
G
D
L
L
V
S
G
Q
C
-------
E
-------
E
E
E
P
I
Q
V
T
EDEVLD
I
L
E
S
V
L
IS
N
M
S
T
S
V
T
R
G
Y
A
L
T
A
I
M
K
L
S
T
R
F
T
C
-
T
V
N
R
I
K
K
V
V
S
I
Y
G
S
S
I
----
D
V
E
L
Q
Q
R
A
V
E
Y
N
A
L
--
F
K
K
Y
D
H
M
R
S
A
L
L
E
R
M
P
V
M
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
51.78
92%
-
- C1 -
-
4NEE
-
AP2A2_RAT
G:
[9-396]
--------
G
M
R
G
L
A
V
F
I
S
D
I
R
N
C
K
S
K
E
A
E
I
K
R
I
N
K
E
L
A
N
I
R
S
K
F
K
G
D
K
A
L
D
G
Y
S
K
K
K
Y
V
C
K
L
L
F
I
F
L
L
G
H
D
I
D
F
G
H
M
E
A
V
N
L
L
S
S
N
R
Y
T
E
K
Q
I
G
Y
L
F
I
S
V
L
V
N
S
N
S
E
L
I
R
L
I
N
N
A
I
K
N
D
L
A
S
R
N
P
T
F
M
G
L
A
L
H
C
I
A
N
V
G
S
R
E
M
A
E
A
F
A
G
E
I
P
K
I
L
V
A
G
D
T
M
D
S
V
K
Q
S
A
A
L
C
L
L
R
L
Y
R
T
S
P
D
L
V
P
M
G
D
W
T
S
R
V
V
H
L
L
N
D
Q
H
L
G
V
V
T
A
A
T
S
L
I
T
T
L
A
Q
K
N
P
E
---
E
---
F
K
T
S
V
S
L
A
V
S
R
L
S
R
I
V
T
S
A
S
T
D
L
-
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
S
V
K
L
L
R
L
L
Q
C
Y
P
P
P
E
D
P
A
V
R
G
R
L
T
E
C
L
E
T
I
L
N
K
A
Q
E
P
P
K
S
K
K
V
Q
H
S
N
A
K
N
A
V
L
F
E
A
I
S
L
I
I
H
H
--------
D
S
E
P
--------
N
L
L
V
R
A
C
N
Q
L
G
Q
F
L
Q
H
R
E
T
N
L
R
Y
L
A
L
E
S
M
C
T
L
A
S
S
E
F
S
H
E
A
V
K
T
H
I
E
T
V
I
N
A
L
K
T
E
R
D
V
S
V
R
Q
R
A
V
D
L
L
Y
A
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
50.19
19%
-56
- C1 -
-
1W63
-
AP1B1_RAT
F:
[14-533]
-----------------------------------
E
I
F
E
L
K
A
E
L
N
S
D
---
K
K
E
K
K
K
E
A
V
K
K
V
I
A
S
M
T
V
G
K
D
V
S
A
L
F
P
D
V
V
N
C
M
Q
T
D
N
L
E
L
K
K
L
V
Y
L
Y
L
M
N
Y
A
K
S
Q
P
D
M
A
I
M
A
V
N
T
F
V
K
D
C
E
D
P
N
P
L
I
R
A
L
A
V
R
T
M
G
C
I
R
V
D
K
I
T
E
Y
L
C
E
P
L
R
K
C
L
--
K
D
E
D
P
Y
V
R
K
T
A
A
V
C
V
A
K
L
H
D
I
N
A
Q
M
V
E
D
Q
G
F
L
D
T
L
K
D
L
I
S
D
S
N
P
M
V
V
A
N
R
V
A
A
L
S
E
I
A
E
S
H
P
S
---
S
N--
L
L
D
L
K
A
Q
S
I
N
K
L
L
T
A
L
N
E
--------------
C
T
E
W
A
Q
I
F
I
L
D
C
L
G
N
Y
M
P
K
D
D
R
----
E
A
Q
S
I
C
E
R
V
T
P
---------
R
L
S
H
A
N
S
--
A
V
V
L
S
A
V
K
V
L
M
K
F
--------
M
---DYYA----
T
L
L
K
K
L
A
P
P
L
V
T
L
L
S
A
-
E
P
E
P
Q
Y
V
P
L
R
N
I
N
L
I
V
Q
K
--
R
P
E
I
L
K
H
E
M
K
V
-
F
F
V
K
Y
-
N
D
P
I
Y
V
K
L
E
K
L
D
I
M
I
R
L
A
S
Q
A
N
I
A
Q
V
L
A
E
L
K
E
Y
A
T
E
V
D
V
D
F
V
R
K
A
V
R
A
I
G
R
C
A
I
K
V
E
Q
S
A
E
R
C
V
S
T
L
L
D
L
I
Q
T
K
V
N
Y
V
V
Q
E
A
I
V
V
I
K
D
I
F
R
K
Y
P
N
K
Y
E
S
V
I
A
T
L
C
E
N
L
D
S
D
-
D
E
P
E
A
R
A
A
M
I
W
I
V
G
E
Y
A
E
-
R
S
D
N
A
-------------------
D
E
L
L
E
------
S
F
L
D
G
F
--
H
D
E
S
T
Q
V
Q
L
Q
L
L
T
A
I
V
K
L
F
L
K
K
P
T
E
T
Q
E
L
V
Q
Q
V
L
S
L
-
A
--
T
Q
D
S
D
N
P
D
L
R
D
R
G
Y
I
Y
W
R
L
L
S
T
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
50.00
18%
-70
- C1 -
-
2VGL
-
AP2B1_HUMAN
B:
[4-582]
-------------------------
S
K
Y
F
T
T
N
K
K
G
E
I
F
E
L
K
A
E
L
N
N
E
---
K
K
E
K
R
K
E
A
V
K
K
V
I
A
A
M
T
V
G
K
D
V
S
S
L
F
P
D
V
V
N
C
M
Q
T
D
N
L
E
L
K
K
L
V
Y
L
Y
L
M
N
Y
A
K
S
Q
P
D
M
A
I
M
A
V
N
S
F
V
K
D
C
E
D
P
N
P
L
I
R
A
L
A
V
R
T
M
G
C
I
R
V
D
K
I
T
E
Y
L
C
E
P
L
R
K
C
L
--
K
D
E
D
P
Y
V
R
K
T
A
A
V
C
V
A
K
L
H
D
I
N
A
Q
M
V
E
D
Q
G
F
L
D
S
L
R
D
L
I
A
D
S
N
P
M
V
V
A
N
A
V
A
A
L
S
E
I
S
E
S
H
P
N
---
S
---
N
L
------
L
D
L
N
P
Q
N
I
N
K
L
L
T
A
L
-
N
E
C
T
------
E
W
G
Q
I
F
I
L
D
C
L
S
N
Y
N
P
K
-
D
D
R
E
A
Q
S
I
C
E
R
V
T
P
R
L
S
--------------
H
A
N
S
A
V
V
L
S
A
V
K
V
L
M
K
F
LELLPKDS
D
Y
Y
N
--------
M
L
L
K
K
L
A
P
P
L
V
T
L
L
S
-
G
E
P
E
V
Q
Y
V
A
L
R
N
I
N
L
I
V
Q
K
--
R
P
E
I
L
K
Q
E
I
K
V
F
F
--
V
K
Y
N
D
P
I
Y
V
K
L
E
K
L
D
I
M
I
R
L
A
S
Q
A
N
I
A
Q
V
L
A
E
L
K
E
Y
A
T
E
V
D
V
D
F
V
R
K
A
V
R
A
I
G
R
C
A
I
K
V
E
Q
S
A
E
R
C
V
S
T
L
L
D
L
I
Q
T
K
V
N
Y
V
V
Q
E
A
I
V
V
I
R
D
I
F
R
K
Y
P
N
K
Y
E
S
I
I
A
T
L
C
E
N
L
D
S
L
D
-
E
P
D
A
R
A
A
M
I
W
I
V
G
E
Y
A
E
-
R
I
-------------------
D
N
A
D
E
L
L
E
------
S
F
L
E
G
F
--
H
D
E
S
T
Q
V
Q
L
T
L
L
T
A
I
V
K
L
F
L
K
K
P
S
-
E
T
Q
E
L
V
Q
Q
V
L
S
-
L
A
T
Q
D
S
D
-
N
P
D
L
R
D
R
G
Y
I
Y
W
R
L
L
S
T
D
P
V
T
A
K
E
V
V
L
S
E
K
P
L
I
S
E
E
T
D
L
I
E
P
T
L
L
D
E
L
I
C
H
I
G
S
L
A
S
V
Y
H
K
P
P
N
A
F
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
49.75
19%
-50
- C1 -
-
2VGL
-
AP2B1_HUMAN
B:
[13-533]
----------------------------------
G
E
I
F
E
L
K
A
E
L
N
N
E
---
K
K
E
K
R
K
E
A
V
K
K
V
I
A
A
M
T
V
G
K
D
V
S
S
L
F
P
D
V
V
N
C
M
Q
T
D
N
L
E
L
K
K
L
V
Y
L
Y
L
M
N
Y
A
K
S
Q
P
D
M
A
I
M
A
V
N
S
F
V
K
D
C
E
D
P
N
P
L
I
R
A
L
A
V
R
T
M
G
C
I
R
V
D
K
I
T
E
Y
L
C
E
P
L
R
K
C
L
--
K
D
E
D
P
Y
V
R
K
T
A
A
V
C
V
A
K
L
H
D
I
N
A
Q
M
V
E
D
Q
G
F
L
D
S
L
R
D
L
I
A
D
S
N
P
M
V
V
A
N
A
V
A
A
L
S
E
I
S
E
S
H
P
N
S--
N
---
L
L
D
L
N
P
Q
N
I
N
K
L
L
T
A
L
N
E
C
--------------
T
E
W
G
Q
I
F
I
L
D
C
L
S
N
Y
N
P
K
D
D
R
----
E
A
Q
S
I
C
E
R
V
T
P
---------
R
L
S
H
A
N
S
--
A
V
V
L
S
A
V
K
V
L
M
K
F
--------
L
E
L
L
PKDSD
Y
Y
N
M
L
L
K
K
L
A
P
P
L
V
T
L
L
-
S
G
E
P
E
V
Q
Y
V
A
L
R
N
I
N
L
I
V
Q
K
--
R
P
E
I
L
K
Q
E
I
K
V
F
F
V
K
Y
N
--
D
P
I
Y
V
K
L
E
K
L
D
I
M
I
R
L
A
S
Q
A
N
I
A
Q
V
L
A
E
L
K
E
Y
A
T
E
V
D
V
D
F
V
R
K
A
V
R
A
I
G
R
C
A
I
K
V
E
Q
S
A
E
R
C
V
S
T
L
L
D
L
I
Q
T
K
V
N
Y
V
V
Q
E
A
I
V
V
I
R
D
I
F
R
K
Y
P
N
K
Y
E
S
I
I
A
T
L
C
E
N
L
D
S
L
-
D
E
P
D
A
R
A
A
M
I
W
I
V
G
E
Y
A
E
-
R
I
D
N
A
-------------------
D
E
L
L
E
------
S
F
L
E
G
F
--
H
D
E
S
T
Q
V
Q
L
T
L
L
T
A
I
V
K
L
F
L
K
K
P
S
E
T
Q
E
L
V
Q
Q
V
L
S
L
-
A
--
T
Q
D
S
D
N
P
D
L
R
D
R
G
Y
I
Y
W
R
L
L
S
T
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
49.08
72%
-103
- C2 -
-
3HS8
-
A:
[36-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
N
F
A
R
F
V
C
K
N
N
G
V
L
F
E
N
Q
L
L
Q
I
G
L
K
S
E
F
R
Q
N
L
G
R
M
F
I
F
Y
G
N
K
T
S
T
Q
F
L
N
F
T
P
T
L
I
C
A
D
D
L
Q
T
N
L
N
L
Q
T
K
P
V
D
P
T
V
D
G
G
A
Q
V
Q
Q
V
V
N
I
E
C
I
S
D
F
T
E
A
P
V
L
N
I
Q
F
R
Y
G
G
T
F
Q
N
V
S
V
K
L
P
I
T
L
N
K
F
F
Q
P
T
E
M
A
S
Q
D
F
F
Q
R
W
K
Q
L
S
N
P
Q
Q
E
V
Q
N
I
F
K
A
K
H
P
M
D
T
E
I
T
K
A
K
I
I
G
F
G
S
A
L
L
E
E
V
D
P
N
P
A
N
F
V
G
A
G
I
I
H
T
K
T
T
Q
I
G
C
L
L
R
L
E
P
N
L
Q
A
Q
M
Y
R
L
T
L
R
T
S
K
D
T
V
S
Q
R
L
C
E
L
L
S
E
Q
F
25
HHSearch
48.98
72%
-103
- C2 -
-
3HS8
-
A:
[36-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
N
F
A
R
F
V
C
K
N
N
G
V
L
F
E
N
Q
L
L
Q
I
G
L
K
S
E
F
R
Q
N
L
G
R
M
F
I
F
Y
G
N
K
T
S
T
Q
F
L
N
F
T
P
T
L
I
C
A
D
D
L
Q
T
N
L
N
L
Q
T
K
P
V
D
P
T
V
D
G
G
A
Q
V
Q
Q
V
V
N
I
E
C
I
S
D
F
T
E
A
P
V
L
N
I
Q
F
R
Y
G
G
T
F
Q
N
V
S
V
K
L
P
I
T
L
N
K
F
F
Q
P
T
E
M
A
S
Q
D
F
F
Q
R
W
K
Q
L
S
N
P
Q
Q
E
V
Q
N
I
F
K
A
K
H
P
M
D
T
E
I
T
K
A
K
I
I
G
F
G
S
A
L
L
E
E
V
D
P
N
P
A
N
F
V
G
A
G
I
I
H
T
K
T
T
Q
I
G
C
L
L
R
L
E
P
N
L
Q
A
Q
M
Y
R
L
T
L
R
T
S
K
D
T
V
S
Q
R
L
C
E
L
L
S
E
Q
F
7
PsiBlast_PDB
47.75
70%
-105
- C2 -
-
1W80
2
A:
[3-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
I
L
A
P
L
A
P
G
S
E
D
N
F
A
R
F
V
C
K
N
N
G
V
L
F
E
N
Q
L
L
Q
I
G
L
K
S
E
F
R
Q
N
L
G
R
M
F
I
F
Y
G
N
K
T
S
T
Q
F
L
N
F
T
P
T
L
I
C
A
D
D
L
Q
T
N
L
N
L
Q
T
K
P
V
D
P
T
V
D
G
G
A
Q
V
Q
Q
V
I
N
I
E
C
I
S
D
F
T
E
A
P
V
L
N
I
Q
F
R
Y
G
G
T
F
Q
N
V
S
V
K
L
P
I
T
L
N
K
F
F
Q
P
T
E
M
A
S
Q
D
F
F
Q
R
W
K
Q
L
S
N
P
Q
Q
E
V
Q
N
I
F
K
A
K
H
P
M
D
T
E
I
T
K
A
K
I
I
G
F
G
S
A
L
L
E
E
V
D
P
N
P
A
N
F
V
G
A
G
I
I
H
T
K
T
T
Q
I
G
C
L
L
R
L
E
P
N
L
Q
A
Q
M
Y
R
L
T
L
R
T
S
K
D
T
V
S
Q
R
L
C
E
L
L
S
E
Q
F