@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HS71A_HUMAN: (2018-07-13 )
MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
Atome Classification :
(26 SA)
.........10........20........30........40.....-...50........60........70........80........90........100......-.110.......120.......130.......140.......150.......160.......170.......180.......-190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380...-....390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550...-....560.......570.......580.......590.......600.......610.......620.......630.......640
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAK
A
A
A
I
G
I
DLGT
T
Y
S
C
V
G
V
FQHG
K
V
E
I
I
ANDQGNRTT
P
S
Y
V
A
FT
D
-
T
E
R
L
I
G
DAAKN
Q
V
ALNPQ
N
T
V
F
D
A
K
R
L
I
G
R
KFG
D
P
V
V
Q
S
DMKHW
P
F
Q
V
INDGDK
P
K
V
Q
V
S
YK-GETKAF
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
YLGYPVT
N
A
V
I
T
V
P
A
YFND
S
Q
R
Q
A
TK
D
A
G
V
I
A
G
L
N
V
L
R
IINEP
T
A
A
A
I
A
YGLDRTG-KGER
N
V
L
I
F
DLGG
G
T
F
D
V
S
I
L
T
IDD
G
I
F
E
V
K
ATAGDTHLGG
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
LSSSTQ
A
S
L
E
I
D
S
L
FE
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
DAKL
D
K
A
Q
I
H
D
L
V
L
VGGSTR
I
P
K
V
Q
K
L
L
Q
D
F
FNGRDLNKSI
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
LMGDKS-E
N
V
Q
D
L
L
L
L
DVA
P
L
SLGLETA
G
G
V
M
T
A
L
I
KRNSTIPTK
Q
T
Q
I
F
T
T
YSDNQP
G
V
L
I
Q
V
YEGERAMTKDN
N
L
L
G
R
F
ELSGIPPAPRGV
P
Q
I
E
V
T
F
DIDAN
G
I
L
N
V
T
ATDKSTGKA
N
K
I
T
I
TNDKGRL
S
K
E
E
I
E
R
M
V
Q
E
A
E
KYK
A
E
D
E
V
Q
R
E
R
V
S
A
K
N
A
L
E
S
Y
A
F
N
M
K
S
AVED-EGLKGKI
S
E
A
D
K
K
K
V
L
D
K
C
Q
E
V
I
S
W
L
D
A
NTLA
E
K
D
E
F
E
H
K
R
K
E
L
E
Q
V
C
N
P
I
I
S
G
L
YQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
3
PsiBlast_PDB
88.74
88%
-68
- C1 -
-
4FL9
3
HSP7C_BOVIN
A:
[4-553]
---
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
N
D
A
G
R
P
K
V
Q
V
E
Y
K
-
G
E
T
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
V
-
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
A
A
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
------------
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
T
V
-----------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.24
88%
-69
- C1 -
-
3C7N
2
HSP7C_BOVIN
B:
[3-547]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
N
D
A
G
R
P
K
V
Q
V
E
Y
K
-
G
E
T
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
V
-
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
D
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
------
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
-----------------------------------------------------------------------------------------------
29
HHSearch
85.69
89%
-62
- C1 -
-
1YUW
-
HSP7C_BOVIN
A:
[1-554]
M
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
N
D
A
G
R
P
K
V
Q
V
E
Y
K
-
G
E
T
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
V
-
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
A
A
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
S
-
E
N
V
Q
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
T
V
E
----------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.45
88%
-62
- C1 -
-
1YUW
-
HSP7C_BOVIN
A:
[1-554]
M
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
N
D
A
G
R
P
K
V
Q
V
E
Y
K
-
G
E
T
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
V
-
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
A
A
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
S
-
E
N
V
Q
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
T
V
E
----------------------------------------------------------------------------------------
14
PsiBlast_PDB
82.93
99%
-96
- C1 -
-
5BPL
2
HS71A_HUMAN
A:
[3-382]
--
K
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
D
K
P
K
V
Q
V
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
G
-
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
K
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
82.70
99%
-93
- C1 -
-
5BN9
2
HS71A_HUMAN
A:
[4-382]
---
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
D
K
P
K
V
Q
V
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
G
-
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
K
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.34
100%
-91
- C1 -
-
2E8A
1
HS71A_HUMAN
A:
[6-385]
--
K
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
D
K
P
K
V
Q
V
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
G
-
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
82.31
100%
-91
- C1 -
-
3AY9
1
HS71A_HUMAN
A:
[8-386]
---
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
D
K
P
K
V
Q
V
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
G
-
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
82.28
100%
-91
- C1 -
-
3ATV
1
HS71A_HUMAN
A:
[7-386]
--
K
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
D
K
P
K
V
Q
V
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
G
-
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
82.21
99%
-94
- C1 -
-
5BPM
1
HS71A_HUMAN
A:
[4-381]
---
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
D
K
P
K
V
Q
V
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
G
-
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
Q
R
A
K
K
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
82.06
100%
-96
- C1 -
-
4J8F
1
F10A1_RAT (first)
A:
[8-388]
M
A
K
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
D
K
P
K
V
Q
V
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
G
-
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
82.05
100%
-98
- C1 -
-
3A8Y
1
HS71A_HUMAN
A:
[5-387]
M
A
K
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
D
K
P
K
V
Q
V
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
G
-
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
82.02
100%
-100
- C1 -
-
3D2F
1
HS71A_HUMAN
B:
[4-382]
---
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
D
K
P
K
V
Q
V
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
G
-
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
81.89
100%
-91
- C1 -
-
3ATU
2
HS71A_HUMAN
A:
[8-386]
---
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
D
K
P
K
V
Q
V
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
G
-
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
81.76
99%
-90
- C1 -
-
1S3X
1
HS71A_HUMAN
A:
[3-382]
--
K
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
I
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
D
K
P
K
V
Q
V
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
G
-
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
81.69
100%
-92
- C1 -
-
5BN8
1
HS71A_HUMAN
A:
[4-382]
---
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
D
K
P
K
V
Q
V
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
G
-
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
81.58
100%
-94
- C1 -
-
2E88
-
HS71A_HUMAN
A:
[6-386]
--
K
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
D
K
P
K
V
Q
V
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
G
-
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
81.57
99%
-96
- C1 -
-
4J8F
1
F10A1_RAT (first)
A:
[8-393]
M
A
K
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
D
K
P
K
V
Q
V
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
G
-
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
L
E
S
-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
81.54
99%
-89
- C1 -
-
4IO8
1
HS71A_HUMAN
A:
[3-379]
--
K
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
D
K
P
K
V
Q
V
S
Y
K
-
G
D
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
G
-
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
81.37
100%
-90
- C1 -
-
3JXU
1
HS71A_HUMAN
A:
[26-403]
---
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
D
K
P
K
V
Q
V
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
G
-
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
78.33
88%
-88
- C1 -
-
1QQM
1
HSP7C_BOVIN
A:
[2-376]
----
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
N
D
A
G
A
P
K
V
Q
V
E
Y
K
-
G
E
T
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
A
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
A
V
-
G
A
E
R
N
V
L
I
F
S
L
G
G
G
T
F
D
V
S
I
L
T
I
E
D
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
A
H
A
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.98
88%
-90
- C1 -
-
2V7Z
1
HSP7C_RAT
A:
[2-382]
-
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
N
D
A
G
R
P
K
V
Q
V
E
Y
K
-
G
E
T
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
A
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
V
-
R
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
T
E
D
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
74.88
99%
-94
- C1 -
-
5BPN
1
HS71A_HUMAN
A:
[6-381]
-----
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
-
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
--
K
P
K
V
Q
V
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
G
---
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
Q
R
A
K
K
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
72.86
57%
-2
- C1 -
-
5TKY
2
SSB1_CHATD
A:
[12-619]
-
V
Y
D
G
A
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
Y
E
G
T
N
V
E
I
I
A
N
E
Q
G
N
F
T
T
P
S
F
V
S
F
T
E
-
N
C
R
L
I
G
E
A
A
K
N
Q
A
A
M
N
P
A
N
T
I
F
D
V
K
R
L
I
G
R
R
F
D
D
P
T
V
K
K
D
M
E
S
W
P
F
K
V
V
D
D
N
G
N
P
K
V
E
V
Q
Y
L
-
G
Q
T
H
T
F
S
P
Q
E
I
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A
M
V
L
T
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M
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E
I
A
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L
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K
K
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E
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A
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I
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A
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N
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R
Q
A
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D
A
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A
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A
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N
V
L
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I
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N
E
P
T
A
A
A
I
A
Y
G
L
G
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G
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N
V
L
I
Y
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L
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G
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A
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L
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A
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A
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L
L
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A
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R
L
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A
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A
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G
A
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T
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N
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A
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G
A
A
V
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A
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I
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A
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--
D
L
L
L
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F
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A
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Q
L
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Y
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V
E
E
I
I
S
D
------------
K
D
K
I
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A
L
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A
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A
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L
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-
A
D
E
L
K
K
K
E
L
A
L
K
R
L
V
T
K
A
M
A
---------------------------------
22
HHSearch
72.32
57%
-2
- C1 -
-
5TKY
2
SSB1_CHATD
B:
[12-619]
-
V
Y
D
G
A
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
Y
E
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-
N
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-
G
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A
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A
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A
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A
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I
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----
D
T
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D
L
L
L
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V
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L
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A
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G
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T
F
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A
----
T
V
Q
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Y
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V
N
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N
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L
G
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A
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R
V
E
E
I
I
S
-----------
G
Q
K
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A
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A
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A
Q
L
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-
A
D
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L
K
K
K
E
L
A
L
K
R
L
V
T
K
A
M
A
---------------------------------
24
HHSearch
69.23
64%
30
- C1 -
-
6ASY
5
BIP_HUMAN
B:
[2-606]
E
D
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
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--
E
G
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N
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L
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G
G
T
F
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L
L
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N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
D
---
Q
D
T
G
D
L
V
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
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T
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V
P
T
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K
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Q
I
F
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----
G
G
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P
L
T
K
D
N
H
L
L
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P
A
P
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N
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L
E
S
Y
A
Y
S
L
K
N
Q
I
G
D
K
E
K
L
G
G
K
L
S
S
E
D
K
E
T
M
E
K
A
V
E
E
K
I
E
W
L
E
S
H
Q
D
A
D
I
E
D
F
K
A
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K
K
E
L
E
E
I
V
Q
P
I
I
S
K
--------------------------------