@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0251: (2017-12-18 )
MSNSFEILMNQLGMPAEMRQAPALAQANIERVVVHKISKVWEFHFVFSNILPIEIFLELKKGLSEEFSKTGNKAVFEIKARSQEFSNQLLQSYYREAFSEGPCASQGFKSLYQNLQVRAEGNQLFIEGSEAIDKEHFKKNHLPNLAKQLEKFGFPTFNCQVEKNDVLTQEQEEAFHAENEQIVQAANEEALRAMEQLEQMAPPPAEEKPVFDFQAKKAAAKPKLDKAEITPMIEVTTEENRLVFEGVVFDVEQKVTRTGRVLINFKMTDYTSSFSMQKWVKNEEEAQKFDLIKKNSWLRVRGNVEMNNFTRDLTMNVQDLQEVVHYERKDLMPEGERRVEFHAHTNMSTMDALPEVEEIVATAAKWGHKAVAITDHGNVQSFPHGYKAAKKAGIQLIYGIEANIVEDRVPIVYNEVEMDLSEATYVVFDVETTGLSAIYNDLIQVAASKMYKGNVIAEFDEFINPGHPLSAFTTELTGITDDHVKNAKPLEQVLQEFQEFCKDTVLVAHNATFDVGFMNANYERHDLPKISQPVIDTLEFARNLYPEYKRHGLGPLTKRFGVALEHHHMANYDAEATGRLLFIFIKEVAEKHGVTDLARLNIDLISPDSYKKARIKHATIYVKNQVGLKNIFKLVSLSNTKYFEGVSRIPRTVLDAHREGLILGSACSEGEVFDVVVSQGVDAAVEVAKYYDFIEVMPPAIYAPLIAKEQVKDMEELQTIIKSLIEVGDRLGKPVLATGNVHYIEPEEEIYREIIVRSLGQGAMINRTIGHGEHAQPAPLPKAHFRTTNEMLDEFAFLGEELARKLVIENTNALAEIFEPVEVVKGDLYTPFIDKAEETVAELTYKKAFEIYGNPLPDIVDLRIEKELTSILGNGFAVIYLASQMLVQRSNERGYLVGSRGSVGSSFVATMIGITEVNPLSPHYVCGQCQYSEFITDGSYGSGFDMPHKDCPNCGHKLSKNGQDIPFETFLGFDGDKVPDIDLNFSGEDQPSAHLDVRDIFGEEYAFRAGTVGTVAAKTAYGFVKGYERDYGKFYRDAEVERLAQGAAGVKRTTGQHPGGIVVIPNYMDVYDFTPVQYPADDVTAEWQTTHFNFHDIDENVLKLDVLGHDDPTMIRKLQDLSGIDPNKIPMDDEGVMALFSGTDVLGVTPEQIGTPTGMLGIPEFGTNFVRGMVDETHPTTFAELLQLSGLSHGTDVWLGNAQDLIKQGIADLSTVIGCRDDIMVYLMHAGLEPKMAFTIMERVRKGLWLKISEEERNGYIEAMKANKVPEWYIESCGKIKYMFPKAHAAAYVMMALRVAYFKVHHPIYYYCAYFSIRAKAFDIKTMGAGLEAIKRRMEEISEKRKNNEASNVEIDLYTTLEIVNEMWERGFKFGKLDLYRSQATEFLIDGDTLIPPFVAMDGLGENVAKQLVRAREEGEFLSKTELRKRGGLSSTLVEKMDEMGILGNMPEDNQLSLFDELF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330..--.....340.......350.......360.....--..370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540-.......550.......560....---....570.......580........590.......600.......610.......620.......630.......640..-.-..-...650.......660.......670.......680......----.-------690-----.........700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810--.........-820.------......830--.....----...840.......-----850------..---------.--------------------------------------....860.----------......870.......880.......890......-.900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020--------....----------------.....--------------1030..---------------.---------------...-...---------------------------1040---......1050-........1060......1070......1080......1090.....-.-1100.......1110-------..----------....1120----------.----------.....1130......1140......1150......1160.......1170......1180......1190...----...1200...--.--.--------------.------------1210.-------.-------.------------.....-------1220...----...-1230...---------------------...1240..--......1250---..------------....1260....-----..1270.....-----.1280-----.........1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390.......1400......1410.....-.-------1420......1430-.---.......1440......1450.....--.1460----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MS
N
S
F
E
I
L
M
N
QLGM
P
A
E
M
R
QAP
A
L
A
Q
A
N
I
E
R
V
V
V
H
K
I
S
K
V
W
E
F
H
F
V
F
SNIL
P
I
E
I
F
L
E
L
K
K
G
L
S
E
E
F
S
KTG
N
K
A
V
F
E
I
KAR
S
Q
E
F
S
N
Q
L
L
Q
S
Y
Y
R
E
A
FSEGP
C
A
S
Q
G
F
K
S
L
Y
QN
L
Q
V
R
AEG
N
Q
L
F
IEGSEAI
D
K
E
H
F
K
KNH
L
P
N
L
A
K
Q
L
E
K
FGFP
T
F
N
C
Q
VEKNDVL
T
Q
E
Q
E
E
A
FHAE
N
E
Q
I
V
Q
AA
N
E
E
A
L
R
A
M
E
Q
L
E
Q
MAPPPAEEKP
V
F
D
FQAKKAAAKPKLDKAEI
T
P
M
I
E
V
TTEEN
R
L
V
F
E
G
V
V
F
D
V
E
Q
K
VTRT
G
R
V
L
I
N
F
KMTDYTSS
F
S
M
Q
K
W
VK
N
E
E
E
A
Q
K
F
D
LIKKN
S
W
L
R
V
RGN
V
E
MNNFTRDLTM
N
V
Q
D
L
Q
E
V
V
H
Y
E
R
K
DLMPE--GE
R
R
V
E
F
H
AHTNM
S
T
M
DALP
E
V
E
E
I
V
A
T
A
A
KWG--
H
K
A
V
A
I
TDHGNVQSFP
H
G
Y
K
A
A
K
KAG
I
Q
L
I
Y
GIEANIVEDRV
P
I
V
Y
N
E
V
EMDLSE
A
T
Y
V
V
F
D
VETT
G
L
S
A
I
Y
N
D
L
I
Q
V
A
A
S
KMYKG
N
V
I
A
E
F
D
E
FINPGHP
L
S
A
F
T
T
E
LTGI
T
D
D
HVKN
A
K
P
L
E
Q
V
L
Q
E
F
Q
E
F
C
K
D
T
V
L
V
AHN
A
T
F
D
V
G
F
MNANYERHDLPKIS
Q
P
V
I
D
T
L
E
F
A
R
-
N
L
Y
P
E
Y
K
RHGL
G
P
L
T
K
R
F
-
G
V
A
L
E
---
H
H
HMANYDAEAT
G
R
L
L
-
F
I
F
I
K
E
V
A
E
KHGVT
D
L
A
R
L
N
I
D
L
ISPDS
Y
K
K
A
R
I
K
H
A
T
I
Y
V
KNQV
G
L
K
N
I
F
K
L
V
SLSN
T
K
-
Y
F
-
E
-
G
V
-
S
RI
P
R
T
V
L
D
A
HRE
G
L
I
LGSACSEG
E
V
F
D
V
V
V
SQG
V
D
A
A
V
E
V
A
----
K
-------
Y
-------
Y
D
F
I
E
VMP
P
A
I
Y
A
P
L
I
A
K
E
Q
V
K
D
M
E
E
L
Q
T
I
I
K
S
L
I
E
V
G
D
RLGK
P
V
LATG
N
V
H
Y
IE
P
E
E
E
I
Y
R
E
I
I
V
R
SLGQG
A
M
I
NRTIGHGEHAQPAPL
P
K
A
HFR
T
T
N
E
M
L
D
E
F
A
F
L
G
E
E
L
A
R
K
L
V
IEN----
T
N
A
L
A
E
I
F
E
-
P
V
E
V
------VKGDLYT-P--
F
I
D
K
A
----
E
E
T
V
A
E
L
T
Y
K
K
A
F
-----
E
I
Y------GN---------P--------------------------------------LP
D
I
V
D
L
R
----------
I
E
K
E
L
T
S
I
LGN
G
F
A
V
I
Y
L
A
S
Q
M
L
V
Q
RSNER
G
Y
L
VG-SRGSV
G
S
S
F
V
A
T
M
IGITEVNPLSPHYVCGQC
Q
Y
S
E
FITDGSYGSGFDMPHKDCPNCGHKLSKNGQDIP
F
E
T
FLGFDGDKVP
D
I
D
L
NFSGEDQPSAH
L
D
V
R
D
IFGEEYAFRAGTV
G
T
V
A
A
K
T
A
-----------
Y
G
F
V
----------------
K
G
Y
E
R
--------------
D
---
Y
G
---------------
K
---------------
F
Y
R
-
D
A
E
---------------------------
V
E
R
L
---
A
Q
GAAGVK---RTTGQHPG
G
I
V
V
IPNYMDVYDFTPVQYPADDVTAE
W
Q
T
T
H
F
N
FHDID-E-
N
-
V
L
K
L
D
VLGHD
D
P
T
-------
M
I
----------
R
K
L
Q
D
LSG----------I----------DPNKIPMDDEG
V
M
A
L
FSGT
D
V
LGV
T
P
E
QIGTPTGML-GIPEF
G
T
N
F
V
R
G
M
VDETH
P
T
T
F
A
E
L
L
Q
L
SGLSHGT
D
----
V
WLG
N
A
Q
D
L
I
--
K
--
Q
--------------
G
------------
I
--
A
D
-------
L
-------
S
------------
T
V
IGC-------
R
D
D
I
M
V
Y
----
L
M
H-AGLE
P
K
M
---------------------
A
F
T
I
--
M
E
R
--
V
RKG
L
W
L
K
IS---EE------------ERNG
Y
I
E
A
MKAN-----KV
P
E
W
Y
I
E
SCG-----
K
I
--------
K
Y
MFP
K
A
H
A
A
A
Y
V
M
M
A
L
R
V
A
Y
F
KVHH
P
I
Y
Y
Y
C
A
Y
F
S
I
R
A
K
A
F
D
I
KTM
G
A
G
L
E
A
I
K
R
R
M
E
E
I
S
E
K
RKNNEAS
N
V
E
I
D
L
Y
T
T
L
E
I
V
N
E
M
W
E
RGFKFGK
L
D
L
Y
R
SQA
T
E
F
L
ID-GDTLI
P
P
F
V
A
MDGL
G
E
N
V
A
K
Q
L
V
R
A
R
EE-G-------E
F
L
S
K
T
E
L
R
KRG---G---
L
S
S
T
L
V
E
K
M
D
EMGILGNMPEDN
Q
L
S
L
--
F
D
ELF----
49
Fugue
95.61
58%
-99
- C2 -
-
3F2B
3
?
A:
[7-1030]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
R
L
E
T
I
V
E
E
E
R
R
V
V
V
Q
G
Y
V
F
D
A
E
V
S
E
L
K
S
G
R
T
L
L
T
M
K
I
T
D
Y
T
N
S
I
L
V
K
M
F
S
R
D
K
E
D
A
E
L
M
S
G
V
K
K
G
M
W
V
K
V
R
G
S
V
Q
N
D
T
F
V
R
D
L
V
I
I
A
N
D
L
N
E
I
A
A
N
E
R
Q
D
T
A
P
E
--
G
E
K
R
V
E
L
H
L
H
T
P
M
S
Q
M
D
A
V
T
S
V
T
K
L
I
E
Q
A
K
K
W
G
--
H
P
A
I
A
V
T
D
H
A
V
V
Q
S
F
P
E
A
Y
S
A
A
K
K
H
G
M
K
V
I
Y
G
L
E
A
N
I
V
D
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
V
T
L
L
A
Q
N
E
T
G
L
K
N
L
F
K
L
V
S
L
S
H
I
Q
-
Y
F
-
H
-
R
V
-
P
R
I
P
R
S
V
L
V
K
H
R
D
G
L
L
V
G
S
G
C
D
K
G
E
L
F
D
--------
N
V
E
D
I
A
----
R
-------
F
-------
Y
D
F
L
E
V
H
P
P
D
V
Y
K
P
L
Y
V
K
----
D
E
E
M
I
K
N
I
I
R
S
I
V
A
L
G
E
K
L
D
I
P
V
V
A
T
G
N
V
H
Y
L
N
P
E
D
K
I
Y
R
K
I
L
I
H
S
Q
G
G
A
----------
N
P
L
N
R
H
E
L
P
D
V
Y
F
R
T
T
N
E
M
L
D
C
F
S
F
L
G
P
E
K
A
K
E
I
V
V
D
N
----
T
Q
K
I
A
S
L
I
G
-
D
V
K
P
------
I
K
D
E
L
Y
T
-
P
--
R
I
E
G
A
----
D
E
E
I
R
E
M
S
Y
R
R
A
K
-----
E
I
Y
------
G
D
---------
P
--------------------------------------
L
P
K
L
V
E
E
R
----------
L
E
K
E
L
K
S
I
I
G
H
G
F
A
V
I
Y
L
I
S
H
K
L
V
K
K
S
L
D
D
G
Y
L
V
G
-
S
R
G
S
V
G
S
S
F
V
A
T
M
T
E
I
T
E
V
N
P
L
P
P
H
Y
V
C
P
N
C
K
H
S
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F
F
N
D
G
S
V
G
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G
F
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L
P
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K
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C
P
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C
G
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K
Y
K
K
D
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L
G
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P
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N
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G
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Y
Q
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K
V
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N
V
Y
R
A
G
T
I
G
T
V
A
D
K
T
A
-----------
Y
G
F
V
----------------
K
A
Y
A
S
--------------
D
---
H
N
---------------
L
---------------
E
L
R
-
G
A
E
---------------------------
I
D
R
L
---
A
A
G
C
T
G
V
K
---
R
T
T
G
Q
H
P
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G
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V
V
P
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Y
M
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D
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S
S
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W
R
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T
H
F
D
F
H
S
I
H
-
D
-
N
-
L
L
K
L
D
I
L
G
H
D
D
P
T
-------
V
I
----------
R
M
L
Q
D
L
S
G
----------
I
----------
D
P
K
T
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P
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N
V
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-
G
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R
F
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Q
M
L
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E
T
R
P
K
T
F
S
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L
V
Q
I
S
G
L
S
H
G
T
D
----
V
W
L
G
N
A
Q
E
L
I
--
Q
--
N
--------------
G
------------
T
--
C
T
-------
L
-------
S
------------
E
V
I
G
C
-------
R
D
D
I
M
V
Y
----
L
I
Y
-
R
G
L
E
P
S
L
---------------------
A
F
K
I
--
M
E
S
--
V
R
K
G
K
G
L
T
---------------------
P
E
F
E
A
E
M
R
K
H
-----
D
V
P
E
W
Y
I
D
S
C
K
-----
K
I
--------
K
Y
M
F
P
K
A
H
A
A
A
Y
V
L
M
A
V
R
I
A
Y
F
K
V
H
H
P
L
L
Y
Y
A
S
Y
F
T
V
R
A
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D
F
D
L
D
A
M
I
K
G
S
A
A
I
R
K
R
I
E
E
I
N
A
K
--
G
I
Q
A
T
A
K
E
K
S
L
L
T
V
L
E
V
A
L
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C
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N
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Y
R
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Q
A
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F
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I
D
-
G
N
S
L
I
P
P
F
N
A
I
P
G
L
G
T
N
V
A
Q
A
I
V
R
A
R
E
E
-
G
-------
E
F
L
S
K
E
D
L
Q
Q
R
G
---
K
---
L
S
K
T
L
L
E
Y
L
E
S
R
G
C
L
D
S
L
P
D
H
N
Q
L
S
L
--
F
--------
29
HHSearch
82.01
57%
11
- C2 -
-
3F2B
3
?
A:
[7-1030]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
R
L
E
T
I
V
E
E
E
R
R
V
V
V
Q
G
Y
V
F
D
A
E
V
S
E
L
K
S
G
R
T
L
L
T
M
K
I
T
D
Y
T
N
S
I
L
V
K
M
F
S
R
D
K
E
D
A
E
L
M
S
G
V
K
K
G
M
W
V
K
V
R
G
S
V
Q
N
D
T
F
V
R
D
L
V
I
I
A
N
D
L
N
E
I
-
A
A
-
N
E
R
Q
D
T
A
PE
G
E
K
R
V
E
L
H
L
H
T
P
M
S
Q
M
D
A
V
T
S
V
T
K
L
I
E
Q
A
K
K
W
G
--
H
P
A
I
A
V
T
D
H
A
V
V
Q
S
F
P
E
A
Y
S
A
A
K
K
H
G
M
K
V
I
Y
G
L
E
A
N
I
V
D
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
H
V
T
L
L
A
Q
N
E
T
G
L
K
N
L
F
K
L
V
S
L
S
H
I
Q
-
Y
F
-
H
-
R
V
-
P
R
I
P
R
S
V
L
V
K
H
R
D
G
L
L
V
G
S
G
C
D
K
G
E
L
F
D
N
--------
V
E
D
I
A
----
R
-------
F
-------
Y
D
F
L
E
V
H
P
P
D
V
Y
K
P
L
----
Y
V
K
D
E
E
M
I
K
N
I
I
R
S
I
V
A
L
G
E
K
L
D
I
P
V
V
A
T
G
N
V
H
Y
L
N
P
E
D
K
I
Y
R
K
I
L
I
H
S
Q
G
G
A
N
P
---
L
N
-------
R
H
E
L
P
D
V
Y
F
R
T
T
N
E
M
L
D
C
F
S
F
L
G
P
E
K
A
K
E
I
V
V
D
N
----
T
Q
K
I
A
S
L
I
G
-
D
V
K
P
------
I
K
D
E
L
Y
T
-
P
--
R
I
E
G
A
----
D
E
E
I
R
E
M
S
Y
R
R
A
K
-----
E
I
Y
------
G
D
---------
P
--------------------------------------
L
P
K
L
V
E
E
R
----------
L
E
K
E
L
K
S
I
I
G
H
G
F
A
V
I
Y
L
I
S
H
K
L
V
K
K
S
L
D
D
G
Y
L
V
G
-
S
R
G
S
V
G
S
S
F
V
A
T
M
T
E
I
T
E
V
N
P
L
P
P
H
Y
V
C
P
N
C
K
H
S
E
F
F
N
D
G
S
V
G
S
G
F
D
L
P
D
K
N
C
P
R
C
G
T
K
Y
K
K
D
G
H
D
I
P
F
E
T
F
L
G
F
K
G
D
K
V
P
D
I
D
L
N
F
S
G
E
Y
Q
P
R
A
H
N
Y
T
K
V
L
F
G
E
D
N
V
Y
R
A
G
T
I
G
T
V
A
D
K
T
A
-----------
Y
G
F
V
----------------
K
A
Y
A
S
--------------
D
---
H
N
---------------
L
---------------
E
L
R
-
G
A
E
---------------------------
I
D
R
L
---
A
A
G
C
T
G
V
K
---
R
T
T
G
Q
H
P
G
G
I
I
V
V
P
D
Y
M
E
I
Y
D
F
T
P
I
Q
Y
P
A
D
D
T
S
S
E
W
R
T
T
H
F
D
F
H
S
I
H
-
D
-
N
-
L
L
K
L
D
I
L
G
H
D
D
P
T
-------
V
I
----------
R
M
L
Q
D
L
S
G
----------
I
----------
D
P
K
T
I
P
T
D
D
P
D
V
M
G
I
F
S
S
T
E
P
L
G
V
T
P
E
Q
I
M
C
N
V
G
T
I
-
G
I
P
E
F
G
T
R
F
V
R
Q
M
L
E
E
T
R
P
K
T
F
S
E
L
V
Q
I
S
G
L
S
H
G
T
D
----
V
W
L
G
N
A
Q
E
L
I
--
Q
--
N
--------------
G
------------
T
--
C
T
-------
L
-------
S
------------
E
V
I
G
C
-------
R
D
D
I
M
V
Y
----
L
I
Y
-
R
G
L
E
P
S
L
---------------------
A
F
K
I
--
M
E
S
--
V
R
K
G
K
G
L
T
P
---------------------
E
F
E
A
E
M
R
K
H
-----
D
V
P
E
W
Y
I
D
S
C
K
-----
K
I
--------
K
Y
M
F
P
K
A
H
A
A
A
Y
V
L
M
A
V
R
I
A
Y
F
K
V
H
H
P
L
L
Y
Y
A
S
Y
F
T
V
R
A
E
D
F
D
L
D
A
M
I
K
G
S
A
A
I
R
K
R
I
E
E
I
N
--
A
K
G
I
Q
A
T
A
K
E
K
S
L
L
T
V
L
E
V
A
L
E
M
C
E
R
G
F
S
F
K
N
I
D
L
Y
R
S
Q
A
T
E
F
V
I
D
-
G
N
S
L
I
P
P
F
N
A
I
P
G
L
G
T
N
V
A
Q
A
I
V
R
A
R
E
E
-
G
-------
E
F
L
S
K
E
D
L
Q
Q
R
G
---
K
---
L
S
K
T
L
L
E
Y
L
E
S
R
G
C
L
D
S
L
P
D
H
N
Q
L
S
L
--
F
--------
32
HHSearch
59.13
24%
-5
- C2 -
-
2HNH
-
DPO3A_ECOLI
A:
[3-898]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
R
F
V
H
L
R
V
H
S
D
Y
S
M
I
D
G
L
A
K
T
A
P
L
V
K
K
A
A
A
L
G
--
M
P
A
L
A
I
T
D
F
T
N
L
C
G
L
V
K
F
Y
G
A
G
H
G
A
G
I
K
P
I
V
G
A
D
F
N
V
Q
C
D
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
E
L
T
H
L
T
V
L
A
A
N
N
T
G
Y
Q
N
L
T
L
L
I
S
K
A
Y
Q
R
-
G
Y
-
G
A
A
G
-
P
I
I
D
R
D
W
L
I
E
L
N
E
G
L
I
L
L
S
G
G
R
M
G
D
V
G
R
S
L
L
R
G
N
S
A
L
V
D
E
C
V
----
A
F
Y
E
E
HFP
D
-------
R
Y
F
L
E
L
I
R
T
G
R
P
-------------
D
E
E
S
Y
L
H
A
A
V
E
L
A
E
A
R
G
L
P
V
V
A
T
N
D
V
R
F
I
D
S
S
D
F
D
A
H
E
I
R
V
A
I
H
D
G
F
T
L
D
D
P
-
K
R
-----
P
R
N
Y
S
P
Q
Q
Y
M
R
S
E
E
E
M
C
E
L
F
A
D
I
P
------
E
A
L
A
N
----
T
V
E
I
A
K
R
C
N
V
T
V
R
L
GEY---
F
L
P
-
Q
F
P
-
T
--
G
D
M
S
T
----
E
D
Y
L
V
K
R
A
K
E
G
L
E
-----
E
R
L
------
A
F
L
FPD
E
E
E
R
L
K
--------------------------------------
R
R
P
E
Y
D
E
R
----------
L
E
T
E
L
Q
V
I
N
Q
M
G
F
P
G
Y
F
L
I
V
M
E
F
I
Q
W
S
K
D
N
G
V
P
V
G
P
G
R
G
S
G
A
G
S
L
V
A
Y
A
L
K
I
T
D
L
D
P
L
E
-----------------------------------------
F
D
L
L
F
E
R
F
L
N
P
E
R
V
S
M
P
D
F
D
V
D
F
C
M
E
K
R
D
Q
V
I
E
H
V
A
D
M
Y
G
R
D
A
V
S
Q
I
I
T
F
G
T
M
A
A
K
A
V
-----------
I
R
D
V
----------------
G
R
V
L
G
HP
Y
G
F
V
D
R
I
S
K
L
IP
P
D--
P
G
MT
L
A
K
A
F
E
A
E
P
Q
L
P
E
I
Y
E
A
------------
D
E
E
-
V
K
A
---------------------------
L
I
D
M
---
A
R
K
L
E
G
V
T
---
R
N
A
G
K
H
A
G
G
V
V
I
A
P
T
--
K
I
T
D
F
A
P
L
Y
C
D
E
E
G
---
K
H
P
V
T
Q
F
D
K
S
D
V
E
-
Y
A
G
-
L
V
K
F
D
F
L
G
L
R
T
L
T
-------
I
I
----------
N
W
A
L
E
M
I
N
----------
K
R
RAKNGEPPL
D
I
A
A
I
P
L
D
D
K
K
S
F
D
M
L
Q
R
S
E
T
T
A
V
F
---------------
Q
L
E
S
R
G
M
K
D
L
I
K
R
L
Q
P
D
C
F
E
D
M
I
A
L
V
A
L
F
R
P
G
P
----
L
Q
S
G
M
V
D
N
F
I
--
D
--
R
K
H
------------
G
R
E
E
I
S
YPDVQWQ
H
--
E
S
-------
L
KPVLEPT
Y
------------
G
I
I
L
Y
-------
Q
E
Q
V
M
Q
I
----
A
Q
V
L
S
G
Y
T
L
G
G
---------------------
A
D
------
M
--
L
R
R
A
M
G
K
K
K
P
E
E
M
A
K
------------
Q
R
S
V
F
A
E
G
A
E
K
N
-----
G
I
N
A
E
L
A
M
K
I
F
D
L
V
E
K
F
A
--------
G
Y
G
F
N
K
S
H
S
A
A
Y
A
L
V
S
Y
Q
T
L
W
L
K
A
H
Y
P
A
E
F
M
A
A
V
M
T
A
D
M
D
N
T
E
-----------------------------------
K
V
V
G
L
V
D
E
C
W
R
M
G
L
K
I
L
P
P
D
I
N
S
G
L
Y
-
H
F
H
V
N
D
D
G
E
I
V
Y
G
I
G
A
I
K
G
V
G
E
G
P
I
E
A
I
I
E
A
R
N
K
G
G
-------
Y
F
R
E
L
F
D
L
C
A
R
T
DTK
K
---
L
N
R
R
V
L
E
K
L
I
M
S
G
A
F
D
R
L
G
P
H
R
A
A
L
------------
31
HHSearch
55.30
24%
10
- C2 -
-
4IQJ
2
DPO3A_THEAQ
D:
[5-960]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
A
H
L
H
Q
H
T
Q
F
S
L
L
D
G
A
A
K
L
Q
D
L
L
K
W
V
K
E
T
T
PE
D
P
A
L
A
M
T
D
H
G
N
L
F
G
A
V
E
F
Y
K
K
A
T
A
M
G
V
K
P
I
I
G
Y
E
A
Y
V
A
A
E
S
R
F
D
-
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
F
H
L
T
L
L
A
K
D
F
T
G
Y
Q
N
L
V
R
L
A
S
R
A
Y
L
E
-
G
F
-
Y
-
E
K
-
P
R
I
D
R
E
I
L
R
E
H
A
Q
G
L
I
A
L
S
G
C
L
G
A
E
I
P
Q
F
I
L
Q
D
R
L
D
L
A
E
A
R
L
N
E
D
L
S
I
------
F
GD-----
R
F
F
I
E
I
Q
N
H
G
L
-------------
P
E
Q
K
K
V
N
Q
V
L
K
E
F
A
R
K
Y
G
L
G
M
V
A
T
N
D
G
H
Y
V
R
K
E
D
A
R
A
H
E
V
L
L
A
I
Q
S
K
T
T
L
D
D
P
E
-
R
-----
W
R
F
P
C
D
E
F
Y
V
K
T
P
E
E
M
R
A
M
L
P
E
A
E
---
W
G
D
E
P
F
D
N
----
T
V
E
I
A
R
M
C
D
V
D
L
P
I
GD
K
M
V
Y
R
I
P
-
R
F
P
L
P
--
E
G
R
T
E
----
A
Q
Y
L
R
E
L
T
F
L
G
L
L
-----
R
R
Y
------
P
D
---------
R
IT
E
A
F
Y
R
E
V
L
R
L
LD
E
R
A
L
A
E
A
L
A
R
VE
E
K
A
W
E
E
L
RKREW
T
A
E
A
I
L
H
R
----------
A
L
Y
E
L
S
V
I
E
R
M
G
F
P
G
Y
F
L
I
V
Q
D
Y
I
N
W
A
R
G
H
G
V
S
V
G
P
G
R
G
S
A
A
G
S
L
V
A
Y
A
V
G
I
T
N
I
D
P
L
R
-----------------------------------------
F
G
L
L
F
E
R
F
L
N
P
E
R
V
S
M
P
D
I
D
T
D
F
S
D
R
E
R
D
R
V
I
Q
Y
V
R
E
R
Y
G
E
D
K
V
A
Q
I
G
T
F
G
S
L
A
S
K
A
A
-----------
L
K
D
V
----------------
A
R
V
Y
G
IP
H
K
K
A
E
E
L
A
K
L
IP
V
Q--
F
G
KPKP
L
Q
E
A
I
Q
VVPE-
L
RAEMEK---------
D
E
R
-
I
R
Q
---------------------------
V
I
E
V
---
A
M
R
L
E
G
L
N
---
R
H
A
S
V
H
A
A
G
V
V
I
A
A
E
--
P
L
T
D
L
V
P
L
M
R
D
Q
E
----
G
R
P
V
T
Q
Y
D
M
G
A
V
E
-
A
L
G
-
L
L
K
M
D
F
L
G
L
R
T
L
T
-------
F
L
----------
D
E
A
R
R
I
V
K
E
S
KGVE----
L
----------
D
Y
D
R
L
P
L
D
D
P
K
T
F
E
L
L
S
R
G
E
T
K
G
V
F
---------------
Q
L
E
S
G
G
M
T
A
T
V
R
G
L
K
P
R
R
L
E
D
I
I
A
L
V
S
L
Y
R
P
G
P
----
M
--
E
H
I
P
T
Y
I
--
R
R
H
H
--------------
G
QEPVSYAEFP--
H
A
E
K
Y
L
R
P
I
LDE
T
-------
Y
------------
G
I
P
V
Y
-------
Q
E
Q
I
M
Q
I
----
A
S
Q
V
A
G
Y
S
L
G
E
---------------------
A
D
------
L
--
L
R
R
A
M
G
K
K
R
V
E
E
M
Q
K
------------
H
R
E
R
F
V
R
G
A
K
E
R
-----
G
V
P
E
E
E
A
N
R
L
F
D
M
L
E
A
F
A
--------
N
Y
G
F
N
K
S
H
A
A
A
Y
S
L
L
S
Y
Q
T
A
Y
V
K
A
H
Y
P
V
E
F
M
A
A
L
L
S
V
E
R
H
D
S
D
---------
K
--------------------------
V
A
E
Y
I
R
D
A
R
A
L
G
I
P
V
L
P
P
D
V
N
R
S
G
F
-
D
F
K
V
V
-
G
E
E
I
L
F
G
L
S
A
V
K
N
V
G
E
M
A
A
R
A
I
L
E
E
R
E
R
G
G
-------
P
F
K
S
L
G
D
F
L
K
R
L
PEQ
V
---
V
N
K
R
A
L
E
S
L
V
K
A
G
A
L
D
A
F
G
D
R
A
R
--------------
30
HHSearch
54.62
24%
17
- C2 -
-
2HPI
-
DPO3A_THEAQ
A:
[5-983]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
A
H
L
H
Q
H
T
Q
F
S
L
L
D
G
A
A
K
L
Q
D
L
L
K
W
V
K
E
T
T
PE
D
P
A
L
A
M
T
D
H
G
N
L
F
G
A
V
E
F
Y
K
K
A
T
A
M
G
V
K
P
I
I
G
Y
E
A
Y
V
A
A
E
S
R
F
D
-
R
-------------------------------------------------------------------------------------------------------------------
K
-----------------------------------------------------------------
R
-----------------------
G
G
Y
F
H
L
T
L
L
A
K
D
F
T
G
Y
Q
N
L
V
R
L
A
S
R
A
Y
L
E
-
G
F
-
Y
-
E
K
-
P
R
I
D
R
E
I
L
R
E
H
A
Q
G
L
I
A
L
S
G
C
L
G
A
E
I
P
Q
F
I
L
Q
D
R
L
D
L
A
E
A
R
L
N
E
D
L
S
I
------
F
GD-----
R
F
F
I
E
I
Q
N
H
G
L
-------------
P
E
Q
K
K
V
N
Q
V
L
K
E
F
A
R
K
Y
G
L
G
M
V
A
T
N
D
G
H
Y
V
R
K
E
D
A
R
A
H
E
V
L
L
A
I
Q
S
K
T
T
L
D
D
P
E
-
R
-----
W
R
F
P
C
D
E
F
Y
V
K
T
P
E
E
M
R
A
M
L
P
E
A
E
---
W
G
D
E
P
F
D
N
----
T
V
E
I
A
R
M
C
D
V
D
L
P
I
GD
K
M
V
Y
R
I
P
-
R
F
P
L----
G
R
T
E
----
A
Q
Y
L
R
E
L
T
F
L
G
L
L
-----
R
R
Y
------
P
D
---------
R
IT
E
A
F
Y
R
E
V
L
R
L
LD
E
R
A
L
A
E
A
L
A
R
VE
E
K
A
W
E
E
L
R
K
REW
T
A
E
A
I
L
H
R
----------
A
L
Y
E
L
S
V
I
E
R
M
G
F
P
G
Y
F
L
I
V
Q
D
Y
I
N
W
A
R
G
H
G
V
S
V
G
P
G
R
G
S
A
A
G
S
L
V
A
Y
A
V
G
I
T
N
I
D
P
L
R
-----------------------------------------
F
G
L
L
F
E
R
F
L
N
P
E
R
V
S
M
P
D
I
D
T
D
F
S
D
R
E
R
D
R
V
I
Q
Y
V
R
E
R
Y
G
E
D
K
V
A
Q
I
G
T
F
G
S
L
A
S
K
A
A
-----------
L
K
D
V
----------------
A
R
V
Y
G
IP
H
K
K
A
E
E
L
A
K
L
IP
V
Q--
F
G
KPKPLQEAE------
L
RAEMEK---------
D
E
R
-
I
R
Q
---------------------------
V
I
E
V
---
A
M
R
L
E
G
L
N
---
R
H
A
S
V
H
A
A
G
V
V
I
A
A
E
--
P
L
T
D
L
V
P
L
M
R
D
Q
E
----
G
R
P
V
T
Q
Y
D
M
G
A
V
E
-
A
L
G
-
L
L
K
M
D
F
L
G
L
R
T
L
T
-------
F
L
----------
D
E
A
R
R
I
V
K
E
S
KGVE----
L
----------
D
Y
D
R
L
P
L
D
D
P
K
T
F
E
L
L
S
R
G
E
T
K
G
V
F
---------------
Q
L
E
S
G
G
M
T
A
T
V
R
G
L
K
P
R
R
L
E
D
I
I
A
L
V
S
L
Y
R
P
G
P
----
M
--
E
H
I
P
T
Y
I
--
R
R
H
H
--------------
G
QEPVSYAEFP--
H
A
E
K
Y
L
R
P
I
LDE
T
-------
Y
------------
G
I
P
V
Y
-------
Q
E
Q
I
M
Q
I
----
A
S
Q
V
A
G
Y
S
L
G
E
---------------------
A
D
------
L
--
L
R
R
A
M
G
K
K
R
V
E
E
M
Q
K
------------
H
R
E
R
F
V
R
G
A
K
E
R
-----
G
V
P
E
E
E
A
N
R
L
F
D
M
L
E
A
F
A
--------
N
Y
G
F
N
K
S
H
A
A
A
Y
S
L
L
S
Y
Q
T
A
Y
V
K
A
H
Y
P
V
E
F
M
A
A
L
L
S
V
E
R
H
D
S
D
---------
K
--------------------------
V
A
E
Y
I
R
D
A
R
A
L
G
I
P
V
L
P
P
D
V
N
R
S
G
F
-
D
F
K
V
V
-
G
E
E
I
L
F
G
L
S
A
V
K
N
V
G
E
M
A
A
R
A
I
L
E
E
R
E
R
G
G
-------
P
F
K
S
L
G
D
F
L
K
R
L
PEQ
V
---
V
N
K
R
A
L
E
S
L
V
K
A
G
A
L
D
A
F
G
D
R
A
R
--------------
1
PsiBlast_PDB
53.28
22%
4
- C2 -
-
4JOM
1
DPO3A_ECOLI
A:
[82-883]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
H
L
T
V
L
A
A
N
N
T
G
Y
Q
N
L
T
L
L
I
S
K
A
Y
Q
R
G
Y
G
-
A
-
A
G
-
P
I
I
D
R
D
W
L
I
E
L
N
E
G
L
I
L
L
S
G
G
R
M
G
D
V
G
R
S
L
L
R
G
N
S
A
L
V
D
E
C
V
----
A
-------
F
-------
Y
E
--
E
H
F
P
D
R
Y
F
L
E
L
I
R
T
G
R
P
D
E
----
E
S
Y
L
H
A
A
V
E
L
A
E
A
R
G
L
P
V
V
A
T
N
D
V
H
F
I
D
S
S
D
F
D
A
H
E
I
R
V
-
A
I
H
D
G
F
T
L
D
D
P
K
R
P
R
N
Y
S
-----
P
Q
Q
Y
M
R
S
E
E
E
M
C
E
L
F
A
D
I
P
E
A
L
A
N
T
V
E
I
A
K
R
C
N
V
T
V
R
L
G
E
Y
F
L
-
P
-
Q
F
------
P
T
G
D
M
S
T
-
E
D
Y
L
V
K
R
A
K
E
G
L
E
E
R
L
A
F
L
F
P
D
E
E
E
-----
R
L
K
------
R
R
---------
P
--------------------------------------
E
---
Y
D
E
R
----------
L
E
T
E
L
Q
V
I
N
Q
M
G
F
P
G
Y
F
L
I
V
M
E
F
I
Q
W
S
K
D
N
G
V
P
V
G
P
G
R
G
S
G
A
G
S
L
V
A
Y
A
L
K
I
T
D
L
D
P
L
------------
E
F
-----------------------------
D
L
L
F
E
R
F
L
N
P
E
R
V
S
M
P
D
F
D
V
D
F
C
M
E
K
R
D
Q
V
I
E
H
V
A
D
M
Y
G
R
D
A
V
S
Q
I
I
T
F
G
T
M
A
A
K
A
V
I
R
D
V
G
R
V
L
GHP
Y
G
F
V
D
R
I
S
K
L
IPPDPGMT
L
A
K
A
F
E
A
--------------
E
P
Q
-
L
P
---------------
E
---------------
I
Y
E
A
D
E
E
---------------------------
V
K
A
L
I
D
M
A
R
K
L
E
G
V
T
---
R
N
A
G
K
H
A
G
G
V
V
I
A
P
T
--
K
I
T
D
F
A
P
L
Y
C
---
D
E
E
G
K
H
P
V
T
Q
F
D
K
S
D
V
E
Y
A
-
G
-
L
V
K
F
D
F
L
G
L
R
T
L
T
I
I
N
W
A
L
E
M
I
----------
N
K
R
R
A
K
N
G
EPP-------
L
----------
D
I
A
A
I
P
L
D
D
K
K
S
F
D
M
L
Q
R
S
E
T
T
A
V
F
---------------
Q
L
E
S
R
G
M
K
D
L
I
K
R
L
Q
P
D
C
F
E
D
M
I
A
L
V
A
L
F
R
P
G
P
----
L
Q
S
G
M
V
D
N
F
I
D
R
K
--
H
--------------
G
------------
R
--
E
E
-------
I
-------
S
------------
Y
P
D
--------------
V
Q
----
W
Q
H
-
E
S
L
K
P
V
L
EPTYGIILY
Q
E
Q
V
M
Q
I
A
Q
V
L
S
G
Y
T
L
G
G
A
D
M
--
L
R
R
A
M
G
K
K
K
P
---
E
E
M
A
K
Q
R
S
V
F
A
E
G
A
E
K
N
G
-
I
N
A
E
L
A
M
-----
K
I
F
D
L
V
E
K
F
A
G
----------------
Y
G
F
N
K
S
H
S
A
A
Y
A
L
V
S
Y
Q
T
L
W
L
K
A
H
Y
P
A
E
F
M
A
A
------------
V
M
T
A
D
M
D
N
T
E
K
-----------------------
V
V
G
L
V
D
E
C
W
R
M
G
L
K
I
L
P
P
D
I
N
S
G
L
Y
H
F
H
V
N
D
-
D
G
E
I
V
Y
G
I
G
A
I
K
G
V
G
E
G
P
I
E
A
I
I
E
A
R
N
K
-
G
GYFRE
L
F
D
L
C
A
R
T
D
T
K
K
---------
L
N
R
R
V
L
E
K
L
----------------------------
50
Fugue
52.96
19%
4
* C2 *
-
2HNH
-
DPO3A_ECOLI
A:
[1-910]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
E
P
R
F
V
H
L
R
V
H
S
D
Y
S
M
I
D
G
L
A
K
T
A
P
L
-
V
K
K
A
A
---
A
L
G
M
P
A
L
A
I
T
D
F
T
N
L
C
G
L
V
K
F
Y
G
A
G
H
G
A
G
I
K
P
I
V
G
A
D
F
N
V
Q
C
D
L
L
G
D
E
L
--
T
H
L
T
V
L
A
A
N
N
T
G
Y
Q
N
L
T
L
L
I
S
K
A
Y
Q
R
-
G
Y
-
G
-
A
A
G
P
I
I
D
R
D
W
L
I
E
L
N
E
G
L
I
L
L
S
G
G
R
M
G
D
V
G
R
S
L
L
R
G
N
S
A
L
V
D
E
C
V
----
A
-------
F
-------
Y
E
E
H
--
F
P
D
R
Y
F
L
E
L
----
I
R
T
G
R
P
D
E
E
S
Y
L
H
A
A
V
E
L
A
E
A
R
G
L
P
V
V
A
T
N
D
V
R
F
I
D
S
S
D
F
D
A
H
E
I
R
V
-
A
I
H
D
G
F
T
L
D
-----
D
P
K
R
P
R
N
Y
S
P
Q
Q
Y
M
R
S
E
E
E
M
C
E
L
F
A
D
I
P
E
A
L
A
N
T
V
E
I
A
K
----
R
C
N
V
T
V
R
L
G
-
E
Y
F
L
------
P
Q
F
P
T
G
D
-
M
--
S
T
E
D
Y
----
L
V
K
R
A
K
E
G
L
E
E
R
L
-----
A
F
L
FPD
E
E
E
R
L
---------
K
--------------------------------------
R
R
P
E
Y
D
E
R
----------
L
E
T
E
L
Q
V
I
N
Q
M
G
F
P
G
Y
F
L
I
V
M
E
F
I
Q
W
S
K
D
N
G
V
P
V
G
P
G
R
G
S
G
A
G
S
L
V
A
Y
A
L
K
I
T
D
L
D
P
L
E
F
D
L
L
-----
F
E
R
F
L
N
P
----
E
R
V
S
M
P
D
F
D
V
D
F
C
----
M
E
K
R
D
Q
V
I
E
H
V
A
D
M
Y
G
R
D
A
V
S
Q
I
-
I
T
F
G
T
M
A
A
K
A
V
I
R
D
V
G
R
V
L
G
H
P
Y
G
F
V
D
R
I
S
K
L
I
P
P
D
P
G
-----------
M
T
L
A
----------------
K
A
F
E
A
--------------
E
P
Q
L
P
E
---------------
I
---------------
Y
E
A
-
D
E
E
---------------------------
V
K
A
L
---
I
D
M
A
R
K
L
E
GVT
R
N
A
G
K
H
A
G
G
V
V
I
A
P
T
--
K
I
T
D
F
A
P
L
Y
C
D
E
E
G
---
K
H
P
V
T
Q
F
D
K
S
D
V
E
-
Y
-
A
G
L
V
K
F
D
F
L
G
L
R
T
L
T
-------
I
I
----------
N
W
A
L
E
M
I
N
K
R
RAKNGEPP
L
----------
D
I
A
A
I
P
L
D
D
K
K
S
F
D
M
L
Q
R
S
E
T
T
A
V
---------------
F
Q
L
E
S
R
G
M
K
D
L
I
K
R
L
Q
P
D
C
F
E
D
M
I
A
L
V
A
L
F
R
P
G
P
----
L
Q
S
G
M
V
D
N
F
I
--
D
--
R
K
H
GR
E
E
I
S
YPDVQW
Q
------------
H
--
E
S
-------
L
-------
K
------------
P
V
L
E
P
TYGIILY
Q
E
Q
V
M
Q
I
----
A
Q
V
-
L
S
G
Y
T
L
G
---------------------
G
A
D
M
--
L
R
R
--
A
M
G
K
K
K
P
E
E
M
---
A
K
------------
Q
R
S
V
F
A
E
G
A
E
K
N
GIN
A
E
L
A
M
K
I
F
D
L
V
E
K
-----
F
A
--------
G
Y
G
F
N
K
S
H
S
A
A
Y
A
L
V
S
Y
Q
T
L
W
L
K
A
H
Y
P
A
E
F
M
A
A
V
M
T
A
D
M
D
-----------------------------------
N
T
E
K
V
V
G
L
V
D
E
C
W
R
M
G
L
K
I
L
P
P
D
I
N
S
G
L
Y
H
F
H
V
N
D
-
D
G
E
I
V
Y
G
I
G
A
I
K
G
V
G
E
G
P
I
E
A
I
I
E
A
R
N
K
G
G
-------
Y
F
R
E
L
F
D
L
C
A
R
T
---
D
TKK
L
N
R
R
V
L
E
K
L
I
M
S
G
A
F
D
R
L
G
P
H
R
A
A
L
M
N
S
L
G
D
A
L
KAAD
8
PsiBlast_PDB
52.45
21%
0
- C2 -
-
2HQA
-
DPO3A_ECOLI
A:
[81-891]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
H
L
T
V
L
A
A
N
N
T
G
Y
Q
N
L
T
L
L
I
S
K
A
Y
Q
R
G
Y
G
-
A
-
A
G
-
P
I
I
D
R
D
W
L
I
E
L
N
E
G
L
I
L
L
S
G
G
R
M
G
D
V
G
R
S
L
L
R
G
N
S
A
L
V
D
E
C
V
----
A
-------
F
-------
Y
E
--
E
H
F
P
D
R
Y
F
L
E
L
I
R
T
G
R
P
D
E
----
E
S
Y
L
H
A
A
V
E
L
A
E
A
R
G
L
P
V
V
A
T
N
D
V
R
F
I
D
S
S
D
F
D
A
H
E
I
R
V
-
A
I
H
D
G
F
T
L
D
D
P
K
R
P
R
N
Y
S
-----
P
Q
Q
Y
M
R
S
E
E
E
M
C
E
L
F
A
D
I
P
E
A
L
A
N
T
V
E
I
A
K
R
C
N
V
T
V
R
L
G
E
Y
F
L
-
P
-
Q
F
------
P
T
G
D
M
S
T
-
E
D
Y
L
V
K
R
A
K
E
G
L
E
E
R
L
A
F
L
F
P
D
E
E
E
-----
R
L
K
------
R
R
---------
P
--------------------------------------
E
---
Y
D
E
R
----------
L
E
T
E
L
Q
V
I
N
Q
M
G
F
P
G
Y
F
L
I
V
M
E
F
I
Q
W
S
K
D
N
G
V
P
V
G
P
G
R
G
S
G
A
G
S
L
V
A
Y
A
L
K
I
T
D
L
D
P
L
------------
E
F
-----------------------------
D
L
L
F
E
R
F
L
N
P
E
R
V
S
M
P
D
F
D
V
D
F
C
M
E
K
R
D
Q
V
I
E
H
V
A
D
M
Y
G
R
D
A
V
S
Q
I
I
T
F
G
T
M
A
A
K
A
V
I
R
D
V
G
R
V
L
GHP
Y
G
F
V
----------------
D
R
I
S
K
L
IPP----------
D
---
P
G
---------------
M
T
L
A
K
A
F
E
A
E
P
Q
L
P
E
I
Y
E
A
-
D
E
E
---------------------------
V
K
A
L
I
D
M
A
R
K
L
E
G
V
T
---
R
N
A
G
K
H
A
G
G
V
V
I
A
P
T
--
K
I
T
D
F
A
P
L
Y
C
---
D
E
E
G
K
H
P
V
T
Q
F
D
K
S
D
V
E
Y
A
-
G
-
L
V
K
F
D
F
L
G
L
R
T
L
T
-------
I
I
N
W
A
L
E
M
I
N
K
R
R
A
K
N
G
E
P
P
----------
L
----------
D
I
A
A
I
P
L
D
D
K
K
S
F
D
M
L
Q
R
S
E
T
T
A
V
F
---------------
Q
L
E
S
R
G
M
K
D
L
I
K
R
L
Q
P
D
C
F
E
D
M
I
A
L
V
A
L
F
R
P
G
P
----
L
Q
S
G
M
V
D
N
F
I
D
R
K
--
H
--------------
G
------------
R
--
E
E
-------
I
-------
S
------------
Y
P
--------------
D
V
Q
----
W
Q
H
-
E
S
L
K
P
V
L
EPTYGIILY
Q
E
Q
V
M
Q
I
A
Q
VLS
G
Y
T
L
G
G
A
D
M
--
L
R
R
A
M
G
K
K
K
P
---
E
E
M
A
K
Q
R
S
V
F
A
E
G
A
E
K
N
G
-
I
N
A
E
L
A
M
-----
K
I
F
D
L
V
E
K
F
A
G
----------------
Y
G
F
N
K
S
H
S
A
A
Y
A
L
V
S
Y
Q
T
L
W
L
K
A
H
Y
P
A
E
F
M
A
A
V
M
T
A
-------------------------------
D
M
D
N
T
E
----
K
V
V
G
L
V
D
E
C
W
R
M
G
L
K
I
L
P
P
D
I
N
S
G
L
Y
H
F
H
V
N
D
-
D
G
E
I
V
Y
G
I
G
A
I
K
G
V
G
E
G
P
I
E
A
I
I
E
A
R
N
K
-
G
GYFRE
L
F
D
L
C
A
R
T
D
T
K
K
---------
L
N
R
R
V
L
E
K
L
I
M
S
G
A
F
D
R
L
-------------------
5
PsiBlast_PDB
51.88
22%
10
- C2 -
-
5FKV
-
DPO3A_ECOLI
A:
[81-897]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
H
L
T
V
L
A
A
N
N
T
G
Y
Q
N
L
T
L
L
I
S
K
A
Y
Q
R
G
Y
G
-
A
-
A
G
-
P
I
I
D
R
D
W
L
I
E
L
N
E
G
L
I
L
L
S
G
G
R
M
G
D
V
G
R
S
L
L
R
G
N
S
A
L
V
D
E
C
V
----
A
-------
F
-------
Y
E
--
E
H
F
P
D
R
Y
F
L
E
L
I
R
T
G
R
P
D
E
----
E
S
Y
L
H
A
A
V
E
L
A
E
A
R
G
L
P
V
V
A
T
N
D
V
R
F
I
D
S
S
D
F
D
A
H
E
I
R
V
-
A
I
H
D
G
F
T
L
D
D
P
K
R
P
R
N
Y
S
-----
P
Q
Q
Y
M
R
S
E
E
E
M
C
E
L
F
A
D
I
P
E
A
L
A
N
T
V
E
I
A
K
R
C
N
V
T
V
R
L
G
E
Y
F
L
-
P
-
Q
F
------
P
T
G
D
M
S
T
-
E
D
Y
L
V
K
R
A
----
K
E
G
L
E
E
---
R
L
A
F
L
FPD
E
E
E
R
------
L
K
---------
R
--------------------------------------
R
P
E
-
Y
D
E
R
----------
L
E
T
E
L
Q
V
I
N
Q
M
G
F
P
G
Y
F
L
I
V
M
E
F
I
Q
W
S
K
D
N
G
V
P
V
G
P
G
R
G
S
G
A
G
S
L
V
A
Y
A
L
K
I
T
D
L
D
P
L
------------
E
F
-----------------------------
D
L
L
F
E
R
F
L
N
P
E
R
V
S
M
P
D
F
D
V
D
F
C
M
E
K
R
D
Q
V
I
E
H
V
A
D
M
Y
G
R
D
A
V
S
Q
I
I
T
F
G
T
M
A
A
K
A
V
I
R
D
V
G
R
V
L
GHP
Y
G
F
V
D
R
I
S
K
L
IPPDPGMT
L
A
K
A
F
E
A
--------------
E
P
Q
-
L
P
---------------
E
---------------
I
Y
E
A
D
E
E
---------------------------
V
K
A
L
I
D
M
A
R
K
L
E
G
V
T
---
R
N
A
G
K
H
A
G
G
V
V
I
A
P
T
--
K
I
T
D
F
A
P
L
Y
C
---
D
E
E
G
K
H
P
V
T
Q
F
D
K
S
D
V
E
Y
A
-
G
-
L
V
K
F
D
F
L
G
L
R
T
L
T
I
I
N
W
A
L
E
M
I
----------
N
K
R
R
A
K
N
G
EPP-------
L
----------
D
I
A
A
I
P
L
D
D
K
K
S
F
D
M
L
Q
R
S
E
T
T
A
V
F
---------------
Q
L
E
S
R
G
M
K
D
L
I
K
R
L
Q
P
D
C
F
E
D
M
I
A
L
V
A
L
F
R
P
G
P
----
L
Q
S
G
M
V
D
N
F
I
D
R
K
--
H
--------------
G
------------
R
--
E
E
-------
I
-------
S
------------
Y
P
D
--------------
V
Q
----
W
Q
H
-
E
S
L
K
P
V
L
EPTYGIILY
Q
E
Q
V
M
Q
I
A
Q
V
LS
G
Y
T
L
G
G
A
D
M
--
L
R
R
A
M
G
K
K
K
P
---
E
E
M
A
K
Q
R
S
V
F
A
E
G
A
E
K
N
G
-
I
N
A
E
L
A
M
-----
K
I
F
D
L
V
E
K
F
A
G
----------------
Y
G
F
N
K
S
H
S
A
A
Y
A
L
V
S
Y
Q
T
L
W
L
K
A
H
Y
P
A
E
F
M
A
A
V
M
T
-------------------------------
A
D
M
D
N
T
E
----
K
V
V
G
L
V
D
E
C
W
R
M
G
L
K
I
L
P
P
D
I
N
S
G
L
Y
H
F
H
V
N
D
-
D
G
E
I
V
Y
G
I
G
A
I
K
G
V
G
E
G
P
I
E
A
I
I
E
A
R
N
K
-
G
GYFRE
L
F
D
L
C
A
R
T
D
T
K
K
---------
L
N
R
R
V
L
E
K
L
----------------------------
6
PsiBlast_PDB
51.84
22%
6
- C2 -
-
5FKW
-
DPO3A_ECOLI
A:
[81-882]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
H
L
T
V
L
A
A
N
N
T
G
Y
Q
N
L
T
L
L
I
S
K
A
Y
Q
R
G
Y
G
-
A
-
A
G
-
P
I
I
D
R
D
W
L
I
E
L
N
E
G
L
I
L
L
S
G
G
R
M
G
D
V
G
R
S
L
L
R
G
N
S
A
L
V
D
E
C
V
----
A
-------
F
-------
Y
E
--
E
H
F
P
D
R
Y
F
L
E
L
I
R
T
G
R
P
D
E
----
E
S
Y
L
H
A
A
V
E
L
A
E
A
R
G
L
P
V
V
A
T
N
D
V
R
F
I
D
S
S
D
F
D
A
H
E
I
R
V
-
A
I
H
D
G
F
T
L
D
D
P
K
R
P
R
N
Y
S
-----
P
Q
Q
Y
M
R
S
E
E
E
M
C
E
L
F
A
D
I
P
E
A
L
A
N
T
V
E
I
A
K
R
C
N
V
T
V
R
L
G
E
Y
F
L
-
P
-
Q
F
------
P
T
G
D
M
S
T
-
E
D
Y
L
V
K
R
A
----
K
E
G
L
E
E
---
R
L
A
F
L
FPD
E
E
E
R
------
L
K
---------
R
--------------------------------------
R
P
E
-
Y
D
E
R
----------
L
E
T
E
L
Q
V
I
N
Q
M
G
F
P
G
Y
F
L
I
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M
E
F
I
Q
W
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K
D
N
G
V
P
V
G
P
G
R
G
S
G
A
G
S
L
V
A
Y
A
L
K
I
T
D
L
D
P
L
------------
E
F
-----------------------------
D
L
L
F
E
R
F
L
N
P
E
R
V
S
M
P
D
F
D
V
D
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M
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K
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Y
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G
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A
A
K
A
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I
R
D
V
G
R
V
L
GHP
Y
G
F
V
D
R
I
S
K
L
IPPDPGMT
L
A
K
A
F
E
A
--------------
E
P
Q
-
L
P
---------------
E
---------------
I
Y
E
A
D
E
E
---------------------------
V
K
A
L
I
D
M
A
R
K
L
E
G
V
T
---
R
N
A
G
K
H
A
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G
V
V
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A
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--
K
I
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D
F
A
P
L
Y
C
---
D
E
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K
H
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V
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D
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D
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-
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L
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L
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L
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I
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W
A
L
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I
----------
N
K
R
R
A
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N
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EPP-------
L
----------
D
I
A
A
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L
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D
K
K
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D
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L
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R
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T
T
A
V
F
---------------
Q
L
E
S
R
G
M
K
D
L
I
K
R
L
Q
P
D
C
F
E
D
M
I
A
L
V
A
L
F
R
P
G
P
----
L
Q
S
G
M
V
D
N
F
I
D
R
K
--
H
--------------
G
------------
R
--
E
E
-------
I
-------
S
------------
Y
P
D
--------------
V
Q
----
W
Q
H
-
E
S
L
K
P
V
L
EPTYGIILY
Q
E
Q
V
M
Q
I
A
Q
V
LS
G
Y
T
L
G
G
A
D
M
--
L
R
R
A
M
G
K
K
K
P
---
E
E
M
A
K
Q
R
S
V
F
A
E
G
A
E
K
N
G
-
I
N
A
E
L
A
M
-----
K
I
F
D
L
V
E
K
F
A
G
----------------
Y
G
F
N
K
S
H
S
A
A
Y
A
L
V
S
Y
Q
T
L
W
L
K
A
H
Y
P
A
E
F
M
A
A
V
M
T
-------------------------------
A
D
M
D
N
T
E
----
K
V
V
G
L
V
D
E
C
W
R
M
G
L
K
I
L
P
P
D
I
N
S
G
L
Y
H
F
H
V
N
D
-
D
G
E
I
V
Y
G
I
G
A
I
K
G
V
G
E
G
P
I
E
A
I
I
E
A
R
N
K
-
G
GYFRE
L
F
D
L
C
A
R
T
D
T
K
K
---------
L
N
R
R
V
L
E
K
L
----------------------------
4
PsiBlast_PDB
51.56
22%
13
- C2 -
-
5FKU
-
DPO3A_ECOLI
A:
[81-893]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
H
L
T
V
L
A
A
N
N
T
G
Y
Q
N
L
T
L
L
I
S
K
A
Y
Q
R
G
Y
G
-
A
-
A
G
-
P
I
I
D
R
D
W
L
I
E
L
N
E
G
L
I
L
L
S
G
G
R
M
G
D
V
G
R
S
L
L
R
G
N
S
A
L
V
D
E
C
V
----
A
-------
F
-------
Y
E
--
E
H
F
P
D
R
Y
F
L
E
L
I
R
T
G
R
P
D
E
----
E
S
Y
L
H
A
A
V
E
L
A
E
A
R
G
L
P
V
V
A
T
N
D
V
R
F
I
D
S
S
D
F
D
A
H
E
I
R
V
-
A
I
H
D
G
F
T
L
D
D
P
K
R
P
R
N
Y
S
-----
P
Q
Q
Y
M
R
S
E
E
E
M
C
E
L
F
A
D
I
P
E
A
L
A
N
T
V
E
I
A
K
R
C
N
V
T
V
R
L
G
E
Y
F
L
-
P
-
Q
F
------
P
T
G
D
M
S
T
-
E
D
Y
L
V
K
R
A
----
K
E
G
L
E
E
---
R
L
A
F
L
FPD
E
E
E
R
------
L
K
---------
R
--------------------------------------
R
P
E
-
Y
D
E
R
----------
L
E
T
E
L
Q
V
I
N
Q
M
G
F
P
G
Y
F
L
I
V
M
E
F
I
Q
W
S
K
D
N
G
V
P
V
G
P
G
R
G
S
G
A
G
S
L
V
A
Y
A
L
K
I
T
D
L
D
P
L
------------
E
F
-----------------------------
D
L
L
F
E
R
F
L
N
P
E
R
V
S
M
P
D
F
D
V
D
F
C
M
E
K
R
D
Q
V
I
E
H
V
A
D
M
Y
G
R
D
A
V
S
Q
I
I
T
F
G
T
M
A
A
K
A
V
I
R
D
V
G
R
V
L
GHP
Y
G
F
V
D
R
I
S
K
L
IPPDPGMT
L
A
K
A
F
E
A
--------------
E
P
Q
-
L
P
---------------
E
---------------
I
Y
E
A
D
E
E
---------------------------
V
K
A
L
I
D
M
A
R
K
L
E
G
V
T
---
R
N
A
G
K
H
A
G
G
V
V
I
A
P
T
--
K
I
T
D
F
A
P
L
Y
C
---
D
E
E
G
K
H
P
V
T
Q
F
D
K
S
D
V
E
Y
A
-
G
-
L
V
K
F
D
F
L
G
L
R
T
L
T
I
I
N
W
A
L
E
M
I
----------
N
K
R
R
A
K
N
G
EPP-------
L
----------
D
I
A
A
I
P
L
D
D
K
K
S
F
D
M
L
Q
R
S
E
T
T
A
V
F
---------------
Q
L
E
S
R
G
M
K
D
L
I
K
R
L
Q
P
D
C
F
E
D
M
I
A
L
V
A
L
F
R
P
G
P
----
L
Q
S
G
M
V
D
N
F
I
D
R
K
--
H
--------------
G
------------
R
--
E
E
-------
I
-------
S
------------
Y
P
D
--------------
V
Q
----
W
Q
H
-
E
S
L
K
P
V
L
EPTYGIILY
Q
E
Q
V
M
Q
I
A
Q
V
LS
G
Y
T
L
G
G
A
D
M
--
L
R
R
A
M
G
K
K
K
P
---
E
E
M
A
K
Q
R
S
V
F
A
E
G
A
E
K
N
G
-
I
N
A
E
L
A
M
-----
K
I
F
D
L
V
E
K
F
A
G
----------------
Y
G
F
N
K
S
H
S
A
A
Y
A
L
V
S
Y
Q
T
L
W
L
K
A
H
Y
P
A
E
F
M
A
A
V
M
T
-------------------------------
A
D
M
D
N
T
E
----
K
V
V
G
L
V
D
E
C
W
R
M
G
L
K
I
L
P
P
D
I
N
S
G
L
Y
H
F
H
V
N
D
-
D
G
E
I
V
Y
G
I
G
A
I
K
G
V
G
E
G
P
I
E
A
I
I
E
A
R
N
K
-
G
GYFRE
L
F
D
L
C
A
R
T
D
T
K
K
---------
L
N
R
R
V
L
E
K
L
----------------------------
2
PsiBlast_PDB
51.40
22%
15
- C2 -
-
2HNH
-
DPO3A_ECOLI
A:
[81-882]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
H
L
T
V
L
A
A
N
N
T
G
Y
Q
N
L
T
L
L
I
S
K
A
Y
Q
R
G
Y
G
-
A
-
A
G
-
P
I
I
D
R
D
W
L
I
E
L
N
E
G
L
I
L
L
S
G
G
R
M
G
D
V
G
R
S
L
L
R
G
N
S
A
L
V
D
E
C
V
----
A
-------
F
-------
Y
E
--
E
H
F
P
D
R
Y
F
L
E
L
I
R
T
G
R
P
D
E
----
E
S
Y
L
H
A
A
V
E
L
A
E
A
R
G
L
P
V
V
A
T
N
D
V
R
F
I
D
S
S
D
F
D
A
H
E
I
R
V
-
A
I
H
D
G
F
T
L
D
D
P
K
R
P
R
N
Y
S
-----
P
Q
Q
Y
M
R
S
E
E
E
M
C
E
L
F
A
D
I
P
E
A
L
A
N
T
V
E
I
A
K
R
C
N
V
T
V
R
L
G
E
Y
F
L
-
P
-
Q
F
------
P
T
G
D
M
S
T
-
E
D
Y
L
V
K
R
A
----
K
E
G
L
E
E
---
R
L
A
F
L
FPD
E
E
E
R
------
L
K
---------
R
--------------------------------------
R
P
E
-
Y
D
E
R
----------
L
E
T
E
L
Q
V
I
N
Q
M
G
F
P
G
Y
F
L
I
V
M
E
F
I
Q
W
S
K
D
N
G
V
P
V
G
P
G
R
G
S
G
A
G
S
L
V
A
Y
A
L
K
I
T
D
L
D
P
L
------------
E
F
-----------------------------
D
L
L
F
E
R
F
L
N
P
E
R
V
S
M
P
D
F
D
V
D
F
C
M
E
K
R
D
Q
V
I
E
H
V
A
D
M
Y
G
R
D
A
V
S
Q
I
I
T
F
G
T
M
A
A
K
A
V
I
R
D
V
G
R
V
L
GHP
Y
G
F
V
D
R
I
S
K
L
IPPDPGMT
L
A
K
A
F
E
A
--------------
E
P
Q
-
L
P
---------------
E
---------------
I
Y
E
A
D
E
E
---------------------------
V
K
A
L
I
D
M
A
R
K
L
E
G
V
T
---
R
N
A
G
K
H
A
G
G
V
V
I
A
P
T
--
K
I
T
D
F
A
P
L
Y
C
---
D
E
E
G
K
H
P
V
T
Q
F
D
K
S
D
V
E
Y
A
-
G
-
L
V
K
F
D
F
L
G
L
R
T
L
T
I
I
N
W
A
L
E
M
I
----------
N
K
R
R
A
K
N
G
EPP-------
L
----------
D
I
A
A
I
P
L
D
D
K
K
S
F
D
M
L
Q
R
S
E
T
T
A
V
F
---------------
Q
L
E
S
R
G
M
K
D
L
I
K
R
L
Q
P
D
C
F
E
D
M
I
A
L
V
A
L
F
R
P
G
P
----
L
Q
S
G
M
V
D
N
F
I
D
R
K
--
H
--------------
G
------------
R
--
E
E
-------
I
-------
S
------------
Y
P
D
--------------
V
Q
----
W
Q
H
-
E
S
L
K
P
V
L
EPTYGIILY
Q
E
Q
V
M
Q
I
A
Q
V
LS
G
Y
T
L
G
G
A
D
M
--
L
R
R
A
M
G
K
K
K
P
---
E
E
M
A
K
Q
R
S
V
F
A
E
G
A
E
K
N
G
-
I
N
A
E
L
A
M
-----
K
I
F
D
L
V
E
K
F
A
G
----------------
Y
G
F
N
K
S
H
S
A
A
Y
A
L
V
S
Y
Q
T
L
W
L
K
A
H
Y
P
A
E
F
M
A
A
------------
V
M
T
A
D
M
D
N
T
E
K
-----------------------
V
V
G
L
V
D
E
C
W
R
M
G
L
K
I
L
P
P
D
I
N
S
G
L
Y
H
F
H
V
N
D
-
D
G
E
I
V
Y
G
I
G
A
I
K
G
V
G
E
G
P
I
E
A
I
I
E
A
R
N
K
-
G
GYFRE
L
F
D
L
C
A
R
T
D
T
K
K
---------
L
N
R
R
V
L
E
K
L
----------------------------
3
PsiBlast_PDB
50.68
22%
4
- C2 -
-
5M1S
-
DPO3A_ECOLI
A:
[81-882]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
H
L
T
V
L
A
A
N
N
T
G
Y
Q
N
L
T
L
L
I
S
K
A
Y
Q
R
G
Y
G
-
A
-
A
G
-
P
I
I
D
R
D
W
L
I
E
L
N
E
G
L
I
L
L
S
G
G
R
M
G
D
V
G
R
S
L
L
R
G
N
S
A
L
V
D
E
C
V
----
A
-------
F
-------
Y
E
--
E
H
F
P
D
R
Y
F
L
E
L
I
R
T
G
R
P
D
E
----
E
S
Y
L
H
A
A
V
E
L
A
E
A
R
G
L
P
V
V
A
T
N
D
V
R
F
I
D
S
S
D
F
D
A
H
E
I
R
V
-
A
I
H
D
G
F
T
L
D
D
P
K
R
P
R
N
Y
S
-----
P
Q
Q
Y
M
R
S
E
E
E
M
C
E
L
F
A
D
I
P
E
A
L
A
N
T
V
E
I
A
K
R
C
N
V
T
V
R
L
G
E
Y
F
L
-
P
-
Q
F
------
P
T
G
D
M
S
T
-
E
D
Y
L
V
K
R
A
K
E
G
L
E
E
R
L
A
F
L
F
P
D
E
E
E
-----
R
L
K
------
R
R
---------
P
--------------------------------------
E
---
Y
D
E
R
----------
L
E
T
E
L
Q
V
I
N
Q
M
G
F
P
G
Y
F
L
I
V
M
E
F
I
Q
W
S
K
D
N
G
V
P
V
G
P
G
R
G
S
G
A
G
S
L
V
A
Y
A
L
K
I
T
D
L
D
P
L
------------
E
F
-----------------------------
D
L
L
F
E
R
F
L
N
P
E
R
V
S
M
P
D
F
D
V
D
F
C
M
E
K
R
D
Q
V
I
E
H
V
A
D
M
Y
G
R
D
A
V
S
Q
I
I
T
F
G
T
M
A
A
K
A
V
I
R
D
V
G
R
V
L
GHP
Y
G
F
V
D
R
I
S
K
L
IPPDPGMT
L
A
K
A
F
E
A
--------------
E
P
Q
-
L
P
---------------
E
---------------
I
Y
E
A
D
E
E
---------------------------
V
K
A
L
I
D
M
A
R
K
L
E
G
V
T
---
R
N
A
G
K
H
A
G
G
V
V
I
A
P
T
--
K
I
T
D
F
A
P
L
Y
C
---
D
E
E
G
K
H
P
V
T
Q
F
D
K
S
D
V
E
Y
A
-
G
-
L
V
K
F
D
F
L
G
L
R
T
L
T
I
I
N
W
A
L
E
M
I
----------
N
K
R
R
A
K
N
G
EPP-------
L
----------
D
I
A
A
I
P
L
D
D
K
K
S
F
D
M
L
Q
R
S
E
T
T
A
V
F
---------------
Q
L
E
S
R
G
M
K
D
L
I
K
R
L
Q
P
D
C
F
E
D
M
I
A
L
V
A
L
F
R
P
G
P
----
L
Q
S
G
M
V
D
N
F
I
D
R
K
--
H
--------------
G
------------
R
--
E
E
-------
I
-------
S
YPDVQWQHESLK
P
V
L
E
P
-------
T
Y
G
I
I
L
Y
Q
E
Q
V
M
Q
I
-
A
Q
V
L
S
G
Y
---------------------
T
L
G
G
--
A
D
M
--
L
R
R
A
M
G
K
K
K
P
---
E
E
M
A
K
Q
R
S
V
F
A
E
G
A
E
K
N
G
-
I
N
A
E
L
A
M
-----
K
I
F
D
L
V
E
K
F
A
G
----------------
Y
G
F
N
K
S
H
S
A
A
Y
A
L
V
S
Y
Q
T
L
W
L
K
A
H
Y
P
A
E
F
M
A
A
------------
V
M
T
A
D
M
D
N
T
E
K
-----------------------
V
V
G
L
V
D
E
C
W
R
M
G
L
K
I
L
P
P
D
I
N
S
G
L
Y
H
F
H
V
N
D
-
D
G
E
I
V
Y
G
I
G
A
I
K
G
V
G
E
G
P
I
E
A
I
I
E
A
R
N
K
-
G
GYFRE
L
F
D
L
C
A
R
T
D
T
K
K
---------
L
N
R
R
V
L
E
K
L
----------------------------
54
Fugue
40.33
25%
-97
- C3 -
-
1WLJ
1
ISG20_HUMAN
A:
[6-178]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
A
M
D
C
E
M
V
G
L
G
P
H
R
E
S
G
L
A
R
C
S
L
V
N
V
H
G
A
V
L
--
Y
D
K
F
I
R
P
E
G
E
I
T
D
Y
R
T
R
V
S
G
V
T
P
Q
H
M
V
G
A
T
P
F
A
V
A
R
L
E
I
L
Q
L
L
K
G
K
L
V
V
G
H
D
L
K
H
D
F
Q
A
L
K
E
D
M
S
G
Y
-------
T
I
Y
D
T
S
T
D
-
R
-
L
L
W
R
E
A
K
L
V
S
L
R
V
L
S
E
R
L
L
H
K
S
I
Q
NSL
L
G
H
S
S
V
E
D
A
R
A
T
M
E
L
Y
-
Q
I
S
Q
R
I
R
A
R
-
R
G
L
P
R
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
40.03
33%
-105
- C2 -
-
4GX8
-
DPO3A_ECOLI (first)
A:
[50-127]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
V
H
L
R
V
H
S
D
Y
S
M
I
D
G
P
A
K
T
A
P
L
V
K
K
A
A
A
L
G
--
M
P
A
L
A
I
T
D
F
T
N
L
C
G
L
V
K
F
Y
G
A
G
H
G
A
G
I
K
P
I
V
G
A
D
F
N
V
Q
C
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
39.08
25%
-37
- C2 -
-
4GX8
-
DPO3A_ECOLI (first)
A:
[45-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
S
--
E
P
R
F
V
H
L
R
V
H
S
D
Y
S
M
I
D
G
P
A
K
T
A
P
L
V
K
K
A
A
A
L
G
--
M
P
A
L
A
I
T
D
F
T
N
L
C
G
L
V
K
F
Y
G
A
G
H
G
A
G
I
K
P
I
V
G
A
D
F
N
V
Q
C
D
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
E
L
T
H
L
T
V
L
A
A
N
N
T
G
Y
Q
N
L
T
L
L
I
S
K
A
Y
Q
R
-
G
Y
G
A
-
A
G
-
P
I
I
D
R
D
W
L
I
E
L
N
E
G
L
I
L
L
S
G
G
R
M
G
D
V
G
R
S
L
L
R
G
N
S
A
L
V
D
E
C
V
----
A
-------
F
Y
E
E
HFPD
R
Y
F
L
E
L
I
R
T
G
R
-------------
P
D
E
E
S
Y
L
H
A
A
V
E
L
A
E
A
R
G
L
P
V
V
A
T
N
D
V
R
F
I
D
S
S
D
F
D
A
H
E
I
R
V
A
I
H
D
G
F
-------------
P
R
N
Y
S
P
Q
Q
Y
M
R
S
E
E
E
M
C
E
L
F
A
D
I
P
------
E
A
L
A
N
----
T
V
E
I
A
K
R
C
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
39.02
33%
-105
- C- -
-
4GX9
-
DPO3A_ECOLI (first)
A:
[50-120]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
V
H
L
R
V
H
S
D
Y
S
M
I
D
G
P
A
K
T
A
P
L
V
K
K
A
A
A
L
G
--
M
P
A
L
A
I
T
D
F
T
N
L
C
G
L
V
K
F
Y
G
A
G
H
G
A
G
I
K
P
I
V
G
A
D
F
N
V
Q
C
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
37.86
32%
-127
- C3 -
-
2P1J
-
DPO3_THEMA
A:
[357-520]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
V
V
L
D
F
E
T
T
G
L
D
P
Q
V
D
E
I
I
E
I
G
A
V
K
I
Q
G
G
Q
I
V
D
E
Y
H
T
L
I
K
P
S
R
E
I
S
R
K
S
S
E
I
T
G
I
T
Q
E
M
L
E
N
K
R
S
I
E
E
V
L
P
E
F
L
G
F
L
E
D
S
I
I
V
A
H
N
A
N
F
D
Y
R
F
L
R
L
W
I
K
K
V
M
G
L
D
W
E
R
P
Y
I
D
T
L
A
-
L
A
-
K
S
L
L
K
L
R
S
Y
S
L
D
S
V
V
E
K
L
-
G
L
G
P
F
---
R
H
H
R
A
L
D
D
A
R
V
T
A
Q
V
F
-
L
R
F
V
-
E
M
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
37.73
25%
-41
- C2 -
-
4GX8
-
DPO3A_ECOLI (first)
B:
[45-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
S
--
E
P
R
F
V
H
L
R
V
H
S
D
Y
S
M
I
D
G
P
A
K
T
A
P
L
V
K
K
A
A
A
L
G
--
M
P
A
L
A
I
T
D
F
T
N
L
C
G
L
V
K
F
Y
G
A
G
H
G
A
G
I
K
P
I
V
G
A
D
F
N
V
Q
C
D
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
E
L
T
H
L
T
V
L
A
A
N
N
T
G
Y
Q
N
L
T
L
L
I
S
K
A
Y
Q
R
-
G
Y
G
A
-
A
G
-
P
I
I
D
R
D
W
L
I
E
L
N
E
G
L
I
L
L
S
G
G
R
M
G
D
V
G
R
S
L
L
R
G
N
S
A
L
V
D
E
C
V
----
A
-------
F
Y
E
E
HFPD
R
Y
F
L
E
L
I
R
T
G
R
-------------
P
D
E
E
S
Y
L
H
A
A
V
E
L
A
E
A
R
G
L
P
V
V
A
T
N
D
V
R
F
I
D
S
S
D
F
D
A
H
E
I
R
V
A
I
H
D
G
F
T
L
----
D
D
P
K
R
--
P
R
N
Y
S
P
Q
Q
Y
M
R
S
E
E
E
M
C
E
L
F
A
D
I
P
------
E
A
L
A
N
----
T
V
E
I
A
K
R
C
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
37.33
21%
-1
- C2 -
-
4IQJ
2
DPO3A_THEAQ
A:
[299-864]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
P
E
G
--
R
T
E
A
Q
Y
L
R
E
L
T
F
L
G
--
L
L
R
R
Y
P
D
R
I
----
T
E
A
F
---
Y
R
-
E
V
L
R
------
L
L
----------
D
E
R
A
----
L
A
E
A
L
A
R
V
E
E
K
A
W
-----
E
E
L
------
R
K
-------------------------------------------------------
R
EWT
A
E
A
I
L
H
R
A
L
Y
E
L
S
V
I
E
R
M
G
F
P
G
Y
F
L
I
V
Q
D
Y
I
N
W
A
R
G
H
G
V
S
V
G
P
G
R
G
S
A
A
G
S
L
V
A
Y
A
V
G
I
T
N
I
D
P
L
R
------------------
F
G
-----------------------
L
L
F
E
R
F
L
N
P
E
R
V
S
M
P
D
I
D
T
D
F
S
D
R
E
R
D
R
V
I
Q
Y
V
R
E
R
Y
G
E
D
K
V
A
Q
I
G
T
F
G
S
L
A
S
K
A
A
--------------
L
----------------
K
D
V
A
R
--------------
V
---
Y
G
---------------
I
---------------
P
H
K
-
K
A
E
E
L
A
K
L
IPKPLQEAELR
A
E
M
E
K
DERI
R
Q
V
I
E
V
---
A
M
R
L
E
G
L
N
---
R
H
A
S
V
H
A
A
G
V
V
I
A
A
E
P
L
T
--
D
L
V
P
L
M
R
D
Q
E
G
R
P
----
V
T
Q
Y
D
M
G
A
V
E
-
A
L
G
-
L
L
K
M
D
F
L
G
L
R
T
L
T
-------
F
L
D
E
A
R
------
R
I
V
K
E
S
K
G
----------
V
E
L
--------
D
Y
D
R
L
P
L
D
D
P
K
T
F
E
L
L
S
R
G
E
T
K
G
V
F
Q
L
E
S
G
G
M
T
A
T
V
R
G
L
K
P
R
R
L
E
D
I
I
A
L
V
S
L
Y
R
P
G
P
M
E
H
I
P
T
Y
I
R
R
H
H
G
Q
E
PVSY
A
E
F
P
H
A
E
K
Y
L
--
R
--
P
--------------
I
------------
L
--
D
E
-------
T
-------
Y
------------
G
I
P
V
Y
-------
Q
E
Q
I
M
Q
I
----
A
S
Q
-
V
A
--------------------------
G
Y
S
L
--
G
E
A
D
L
L
R
R
A
M
G
K
K
R
V
---
E
E
M
Q
K
---------
H
R
E
R
F
V
R
G
A
K
E
R
-----
G
V
P
E
---
E
E
A
N
-----
R
L
F
D
M
L
E
A
F
A
N
Y
G
F
N
K
S
H
A
A
A
Y
S
L
L
S
Y
Q
T
A
Y
V
K
A
H
Y
P
V
E
F
M
A
A
L
L
S
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------