@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKJ4: (2017-10-26 )
MPIITLPNGDQKSFDHPVSVMEVAQSIGPGLAKNTVAGRVNDRLVDACDLITEDSTLQIITPKDEEGLEIIRHSCAHLVGHAVKQLFPEAKMVIGPVIEEGFYYDIWMPCPFTLDDMAAIEERMKKLIDQDYDVIKKMTPRDEVIKVFTDRGEEYKLRLVEDMPEEKAMGLYYHQEYVDMCRGPHVPNTKFLKSFKLTKISGAYWRGDAKNEQLQRIYGTAWADKKQLAAYIKRIEEAENRDHRKIGKALDLFHMQEEAPGMVFWHANGWTIYQVLEQYMRKVQQDNGYQEIKTPQIVDFTLWEKSGHAANYAENMFTTHSESRNYAVKPMNCPCHVQVFNQGLKSYRDLPIRLAEFGSCHRNEPSGSLHGIMRVRGFTQDDAHIFCTKEQIGKEVADFIKLTLDVYKDFGFEEVQMKLSTRPEKRVGDDALWDLAEKSLADALDAAGLEWELQPGEGAFYGPKIEFSLKDCLGRVWQCGTIQCDFNLPVRLDASYVTEENERDQPVMLHRAILGSFERFIGILIEHYAGFMPPWLSPVQACVMNITDSQAEASEQVVAKLKENGLRAISDLRNEKIGFKIRERTLERIPYLLVLGDREVEEGTVNVRTRSGKNLGTMSVDAFIDLVKSAVAERGRYIVE
Atome Classification :
(29 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160........170.......180.......190.......200.......210.......220.......230.......240.......250.-......260.......270.......280..-...-..290.......300.......310.....---..320-........330.......340.......350.......360.......370.......380.......390.......400.....-..-410---.---......420----.......430.......440.......450.......460.......470.......480.......490.......500.-.......510.......520.......530.......540.....-..550-.........560.--------------......570-------------...-......580.......590.......600.......610...-....620.......630.......640
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
P
I
I
TLPNGDQKSFDHP
V
S
V
M
E
V
A
Q
SIGPG
L
A
KNTVAGRVN
D
R
L
V
D
A
C
D
LITED
S
T
L
Q
I
ITPKDEE
G
L
E
I
I
R
H
S
C
A
H
L
V
G
H
A
V
K
Q
LFPE
A
K
M
V
I
G
P
VIEE
G
F
Y
Y
D
I
WMPCPF
T
L
D
D
M
A
A
I
E
E
R
M
K
K
L
I
DQ
D
Y
D
V
I
K
KMT
P
R
D
E
V
I
K
V
F
TDRGE
E
Y
K
L
R
L
V
-EDMPEEK
A
M
G
L
Y
Y
H
Q
E
Y
V
D
M
CRGPHVP
N
T
K
F
L
K
SFKLTKIS
G
A
Y
WRGDAK
N
E
Q
L
Q
R
I
Y
GTAWA
D
K
K
Q
L
A
A
Y
I
K
R
I
E
E
AEN
R
D
H
R
K
I
G
K
A
L
D
L
F
-
H
MQEEAP
G
M
V
F
W
HANGW
T
I
Y
Q
V
L
E
Q
Y
M
R
K
V
Q
-QDN-GYQEIKT
P
Q
I
V
D
F
T
L
WEKSGHA
A
N
Y
A
E
N
M
F
---TTHS--ESR
N
Y
AVKPMNCP
C
H
V
Q
V
F
N
Q
G
L
K
S
YRDLP
I
R
L
A
E
FGSCHRNEPSG
S
L
H
G
I
M
R
VRGFTQDD
A
H
I
F
C
T
K
E
Q
I
G
K
E
V
A
D
F
I
K
L
T
L
D
V
Y
-
K
D-F
G
F
---
E
---
E
V
Q
M
K
LSTR----PEKRVG
D
D
A
L
W
D
L
A
E
K
S
L
A
D
A
L
D
AAG
L
E
W
E
LQPGEGAFYG
P
K
I
E
F
S
L
K
D
C
L
G
R
VWQC
G
T
I
Q
C
DFNL
P
V
R
L
D
A
S
YVTEE-NE-RDQ
P
V
M
L
H
R
A
I
L
G
S
F
E
R
F
I
G
I
L
I
E
H
Y
AGFMP
P
W
L
S
P
V
Q
A
C
V
M
NIT-DS
Q
---
A
E
A
S
E
Q
V
V
A
K
L
K
E--------------N
G
L
R
A
I
S
---------------
D
LR-NEKIG
F
K
I
R
E
R
T
L
E
RI
P
Y
L
L
V
LGDREVEE
G
T
V
N
V
R
TRSGKNL-G
T
M
S
V
D
A
F
I
D
L
V
K
S
A
V
A
ERGRYIVE
1
PsiBlast_PDB
77.92
63%
-40
- C2 -
-
1QF6
1
SYT_ECOLI
A:
[2-635]
-
P
V
I
T
L
P
D
G
S
Q
R
H
Y
D
H
A
V
S
P
M
D
V
A
L
D
I
G
P
G
L
A
K
A
C
I
A
G
R
V
N
G
E
L
V
D
A
C
D
L
I
E
N
D
A
Q
L
S
I
I
T
A
K
D
E
E
G
L
E
I
I
R
H
S
C
A
H
L
L
G
H
A
I
K
Q
L
W
P
H
T
K
M
A
I
G
P
V
I
D
N
G
F
Y
Y
D
V
D
L
D
R
T
L
T
Q
E
D
V
E
A
L
E
K
R
M
H
E
L
A
E
K
N
Y
D
V
I
K
K
K
V
S
W
H
E
A
R
E
T
F
A
N
R
G
E
S
Y
K
V
S
I
L
D
E
N
I
A
H
D
D
K
P
G
L
Y
F
H
E
E
Y
V
D
M
C
R
G
P
H
V
P
N
M
R
F
C
H
H
F
K
L
M
K
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
W
A
D
K
K
A
L
N
A
Y
L
Q
R
L
E
E
A
A
K
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
9
PsiBlast_PDB
67.45
65%
-104
- C1 -
-
1EVL
1
SYT_ECOLI
A:
[1-394]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
10
PsiBlast_PDB
67.40
65%
-104
- C1 -
-
1FYF
1
SYT_ECOLI
A:
[1-394]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
38
PsiBlast_CBE
67.00
65%
-103
- C1 -
-
1EVK
1
SYT_ECOLI
B:
[1-394]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
7
PsiBlast_PDB
66.91
65%
-105
- C1 -
-
4P3P
5
SYT_ECOLI
A:
[2-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
12
PsiBlast_PDB
66.79
42%
-28
- C1 -
-
1NYQ
1
SYT_STAAW
A:
[6-632]
---
I
Q
F
P
D
G
N
K
K
A
F
D
K
G
T
T
T
E
D
I
A
Q
S
I
S
P
G
L
R
K
K
A
V
A
G
K
F
N
G
Q
L
V
D
L
T
K
P
L
E
T
D
G
S
I
E
I
V
T
P
G
S
E
E
A
L
E
V
L
R
H
S
T
A
H
L
M
A
H
A
I
K
R
L
Y
G
N
V
K
F
G
V
G
P
V
I
E
G
G
F
Y
Y
D
F
D
I
D
Q
N
I
S
S
D
D
F
E
Q
I
E
K
T
M
K
Q
I
V
N
E
N
M
K
I
E
R
K
V
V
S
R
D
E
A
K
E
L
F
S
N
--
D
E
Y
K
L
E
L
I
-
D
A
I
P
E
D
E
N
V
T
L
Y
S
Q
G
D
F
T
D
L
C
R
G
V
H
V
P
S
T
A
K
I
K
E
F
K
L
L
S
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
F
F
D
K
K
E
L
K
A
H
L
Q
M
L
E
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
T
N
S
Q
L
V
G
A
G
L
P
L
W
L
P
N
G
A
T
I
R
R
E
I
E
R
Y
I
V
D
K
E
-
V
S
M
-
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
K
T
S
G
H
W
D
H
Y
Q
E
D
M
F
---
P
P
M
Q
LD
E
T
E
S
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
P
H
S
Y
R
E
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
G
L
Q
R
V
R
G
M
T
L
N
D
S
H
I
F
V
R
P
D
Q
I
K
E
E
F
K
R
V
V
N
M
I
I
D
V
Y
-
K
D
-
F
G
F
---
E
---
D
Y
S
F
R
L
S
Y
R
D
PED
K
E
K
Y
F
D
D
D
D
M
W
N
K
A
E
N
M
L
K
E
A
A
D
E
L
G
L
S
Y
E
E
A
I
G
E
A
A
F
Y
G
P
K
L
D
V
Q
V
K
T
A
M
G
K
E
E
T
L
S
T
A
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
I
G
Q
D
-
G
E
-
H
H
R
P
V
V
I
H
R
G
V
V
S
T
M
E
R
F
V
A
F
L
T
E
E
T
K
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
V
N
V
D
L
H
---
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
G
V
R
V
S
I
---------------
D
D
R
-
N
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
D
K
E
V
E
N
N
Q
V
N
V
R
Q
Y
G
S
Q
D
Q
-
E
T
V
E
K
D
E
F
I
----------------
2
PsiBlast_PDB
66.74
65%
-103
- C1 -
-
4HWO
1
SYT_ECOLI
A:
[3-396]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
34
PsiBlast_CBE
66.70
65%
-104
- C1 -
-
1FYF
1
SYT_ECOLI
B:
[1-394]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
8
PsiBlast_PDB
66.52
65%
-101
- C1 -
-
1EVK
-
SYT_ECOLI
A:
[1-394]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
25
PsiBlast_CBE
66.51
65%
-105
- C1 -
-
4P3P
6
SYT_ECOLI
B:
[2-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
37
PsiBlast_CBE
66.49
65%
-99
- C1 -
-
1EVL
1
SYT_ECOLI
B:
[1-394]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
13
PsiBlast_PDB
66.38
42%
-23
- C1 -
-
1NYR
2
SYT_STAAW
A:
[6-632]
---
I
Q
F
P
D
G
N
K
K
A
F
D
K
G
T
T
T
E
D
I
A
Q
S
I
S
P
G
L
R
K
K
A
V
A
G
K
F
N
G
Q
L
V
D
L
T
K
P
L
E
T
D
G
S
I
E
I
V
T
P
G
S
E
E
A
L
E
V
L
R
H
S
T
A
H
L
M
A
H
A
I
K
R
L
Y
G
N
V
K
F
G
V
G
P
V
I
E
G
G
F
Y
Y
D
F
D
I
D
Q
N
I
S
S
D
D
F
E
Q
I
E
K
T
M
K
Q
I
V
N
E
N
M
K
I
E
R
K
V
V
S
R
D
E
A
K
E
L
F
S
N
--
D
E
Y
K
L
E
L
I
-
D
A
I
P
E
D
E
N
V
T
L
Y
S
Q
G
D
F
T
D
L
C
R
G
V
H
V
P
S
T
A
K
I
K
E
F
K
L
L
S
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
F
F
D
K
K
E
L
K
A
H
L
Q
M
L
E
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
T
N
S
Q
L
V
G
A
G
L
P
L
W
L
P
N
G
A
T
I
R
R
E
I
E
R
Y
I
V
D
K
E
-
V
S
M
-
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
K
T
S
G
H
W
D
H
Y
Q
E
D
M
F
---
P
P
M
Q
LD
E
T
E
S
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
P
H
S
Y
R
E
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
G
L
Q
R
V
R
G
M
T
L
N
D
S
H
I
F
V
R
P
D
Q
I
K
E
E
F
K
R
V
V
N
M
I
I
D
V
Y
-
K
D
-
F
G
F
---
E
---
D
Y
S
F
R
L
S
Y
R
D
P
ED
K
E
K
Y
F
D
D
D
D
M
W
N
K
A
E
N
M
L
K
E
A
A
D
E
L
G
L
S
Y
E
E
A
I
G
E
A
A
F
Y
G
P
K
L
D
V
Q
V
K
T
A
M
G
K
E
E
T
L
S
T
A
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
I
G
Q
D
-
G
E
-
H
H
R
P
V
V
I
H
R
G
V
V
S
T
M
E
R
F
V
A
F
L
T
E
E
T
K
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
V
N
V
D
L
H
---
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
G
V
R
V
S
I
---------------
D
D
R
-
N
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
D
K
E
V
E
N
N
Q
V
N
V
R
Q
Y
G
S
Q
D
Q
-
E
T
V
E
K
D
E
F
I
----------------
26
PsiBlast_CBE
66.25
65%
-101
- C1 -
-
4P3O
6
SYT_ECOLI
B:
[2-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
36
PsiBlast_CBE
66.13
65%
-101
- C1 -
-
1EVL
1
SYT_ECOLI
C:
[1-394]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
5
PsiBlast_PDB
65.76
65%
-104
- C1 -
-
4HWS
1
SYT_ECOLI
A:
[3-396]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
24
PsiBlast_CBE
65.70
65%
-103
- C1 -
-
4HWO
1
SYT_ECOLI
B:
[3-396]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
6
PsiBlast_PDB
65.64
65%
-104
- C1 -
-
4P3O
5
SYT_ECOLI
A:
[2-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
35
PsiBlast_CBE
65.54
65%
-101
- C1 -
-
1EVL
1
SYT_ECOLI
D:
[1-394]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
22
PsiBlast_CBE
65.41
65%
-103
- C1 -
-
4HWR
1
SYT_ECOLI
B:
[3-396]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
23
PsiBlast_CBE
65.40
65%
-101
- C1 -
-
4HWP
1
SYT_ECOLI
B:
[3-396]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
3
PsiBlast_PDB
65.37
65%
-102
- C1 -
-
4HWP
1
SYT_ECOLI
A:
[3-396]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
21
PsiBlast_CBE
65.19
65%
-102
- C1 -
-
4HWS
1
SYT_ECOLI
B:
[3-396]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
4
PsiBlast_PDB
65.11
65%
-102
- C1 -
-
4HWR
1
SYT_ECOLI
A:
[3-396]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
-
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
---
T
T
S
S
--
E
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
---
E
---
K
I
V
V
K
L
S
T
R
----
P
E
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
-
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
S
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
R
V
K
A
---------------
D
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
------
14
PsiBlast_PDB
56.86
44%
-95
- C1 -
-
4HWT
1
SYTC_HUMAN
A:
[3-391]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
R
D
Q
E
L
Y
-
F
F
H
E
L
S
P
G
S
C
F
F
L
P
K
G
A
Y
I
Y
N
A
L
I
E
F
I
R
S
E
Y
-
R
K
R
-
G
F
Q
E
V
V
T
P
N
I
F
N
S
R
L
W
M
T
S
G
H
W
Q
H
Y
S
E
N
M
F
---
S
F
E
V
--
E
K
E
L
F
A
L
K
P
M
N
C
P
G
H
C
L
M
F
D
H
R
P
R
S
W
R
E
L
P
L
R
L
A
D
F
G
V
L
H
R
N
E
L
S
G
A
L
T
G
L
T
R
V
R
R
F
Q
Q
D
D
A
H
I
F
C
A
M
E
Q
I
E
D
E
I
K
G
C
L
D
F
L
R
T
V
Y
-
S
V
-
F
G
F
-------
S
F
K
L
N
L
S
T
R
----
P
E
K
F
L
G
D
I
E
V
W
D
Q
A
E
K
Q
L
E
N
S
L
N
E
F
G
E
K
W
E
L
N
S
G
D
G
A
F
Y
G
P
K
I
D
I
Q
I
K
D
A
I
G
R
Y
H
Q
C
A
T
I
Q
L
D
F
Q
L
P
I
R
F
N
L
T
Y
V
S
----
D
-
K
K
R
P
V
I
V
H
R
A
I
L
G
S
V
E
R
M
I
A
I
L
T
E
N
Y
G
G
K
W
P
F
W
L
S
P
R
Q
V
M
V
V
P
V
G
-
P
T
C
---
D
E
Y
A
Q
K
V
R
Q
Q
F
H
D
--------------
A
K
F
M
A
D
I
---------------
D
L
D
P
G
C
T
L
N
K
K
I
R
N
A
Q
L
A
Q
Y
N
F
I
L
V
V
G
E
K
E
K
I
S
G
T
V
N
I
R
T
R
D
N
K
V
H
-
G
E
R
T
I
S
E
T
I
E
R
L
Q
------------
78
HHSearch
55.39
44%
-75
- C1 -
-
4HWT
1
SYTC_HUMAN
A:
[3-401]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
R
D
Q
E
L
Y
-
F
F
H
E
L
S
P
G
S
C
F
F
L
P
K
G
A
Y
I
Y
N
A
L
I
E
F
I
R
S
E
Y
-
R
K
R
-
G
F
Q
E
V
V
T
P
N
I
F
N
S
R
L
W
M
T
S
G
H
W
Q
H
Y
S
E
N
M
F
---
S
F
E
V
--
E
K
E
L
F
A
L
K
P
M
N
C
P
G
H
C
L
M
F
D
H
R
P
R
S
W
R
E
L
P
L
R
L
A
D
F
G
V
L
H
R
N
E
L
S
G
A
L
T
G
L
T
R
V
R
R
F
Q
Q
D
D
A
H
I
F
C
A
M
E
Q
I
E
D
E
I
K
G
C
L
D
F
L
R
T
V
Y
-
S
V
-
F
G
F
---
S
----
F
K
L
N
L
S
T
R
----
P
E
K
F
L
G
D
I
E
V
W
D
Q
A
E
K
Q
L
E
N
S
L
N
E
F
G
E
K
W
E
L
N
S
G
D
G
A
F
Y
G
P
K
I
D
I
Q
I
K
D
A
I
G
R
Y
H
Q
C
A
T
I
Q
L
D
F
Q
L
P
I
R
F
N
L
T
Y
V
S
-----D
K
K
R
P
V
I
V
H
R
A
I
L
G
S
V
E
R
M
I
A
I
L
T
E
N
Y
G
G
K
W
P
F
W
L
S
P
R
Q
V
M
V
V
P
V
G
-
P
T
C
---
D
E
Y
A
Q
K
V
R
Q
Q
F
H
D
--------------
A
K
F
M
A
D
I
---------------
D
L
D
P
G
C
T
L
N
K
K
I
R
N
A
Q
L
A
Q
Y
N
F
I
L
V
V
G
E
K
E
K
I
S
G
T
V
N
I
R
T
R
D
N
K
V
H
-
G
E
R
T
I
S
E
T
I
E
R
L
Q
Q
L
K
E
F
R
S
K
Q
A
--
41
PsiBlast_CBE
55.32
44%
-72
- C1 -
-
4HWT
1
SYTC_HUMAN
B:
[3-391]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
R
D
Q
E
L
Y
-
F
F
H
E
L
S
P
G
S
C
F
F
L
P
K
G
A
Y
I
Y
N
A
L
I
E
F
I
R
S
E
Y
-
R
K
R
-
G
F
Q
E
V
V
T
P
N
I
F
N
S
R
L
W
M
T
S
G
H
W
Q
H
Y
S
E
N
M
F
---
S
F
E
V
--
E
K
E
L
F
A
L
K
P
M
N
C
P
G
H
C
L
M
F
D
H
R
P
R
S
W
R
E
L
P
L
R
L
A
D
F
G
V
L
H
R
N
E
L
S
G
A
L
T
G
L
T
R
V
R
R
F
Q
Q
D
D
A
H
I
F
C
A
M
E
Q
I
E
D
E
I
K
G
C
L
D
F
L
R
T
V
Y
-
S
V
-
F
G
F
-------
S
F
K
L
N
L
S
T
R
----
P
E
K
F
L
G
D
I
E
V
W
D
Q
A
E
K
Q
L
E
N
S
L
N
E
F
G
E
K
W
E
L
N
S
G
D
G
A
F
Y
G
P
K
I
D
I
Q
I
K
D
A
I
G
R
Y
H
Q
C
A
T
I
Q
L
D
F
Q
L
P
I
R
F
N
L
T
Y
V
S
H
D
G
D
D
-
K
K
R
P
V
I
V
H
R
A
I
L
G
S
V
E
R
M
I
A
I
L
T
E
N
Y
G
G
K
W
P
F
W
L
S
P
R
Q
V
M
V
V
P
V
G
-
P
T
C
---
D
E
Y
A
Q
K
V
R
Q
Q
F
H
D
--------------
A
K
F
M
A
D
I
---------------
D
L
D
P
G
C
T
L
N
K
K
I
R
N
A
Q
L
A
Q
Y
N
F
I
L
V
V
G
E
K
E
K
I
S
G
T
V
N
I
R
T
R
D
N
K
V
H
-
G
E
R
T
I
S
E
T
I
E
R
L
Q
------------
73
HHSearch
40.63
37%
14
* C1 *
-
3UH0
1
SYTM_YEAST
A:
[32-458]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
A
T
M
T
S
M
V
S
Q
R
Q
D
L
F
-
M
T
D
P
L
S
P
G
S
M
F
F
L
P
N
G
A
K
I
F
N
K
L
I
E
F
M
K
L
Q
Q
K
F
K
F
-
G
F
N
E
V
V
T
P
L
I
Y
K
K
T
L
W
E
K
S
G
H
W
E
N
Y
A
D
D
M
F
---
K
V
E
T
-----
E
Y
G
L
K
P
M
N
C
P
G
H
C
L
I
F
G
K
K
D
R
S
Y
N
E
L
P
L
R
F
S
D
F
S
P
L
H
R
N
E
A
S
G
A
L
S
G
L
T
R
L
R
K
F
H
Q
D
D
G
H
I
F
C
T
P
S
Q
V
K
S
E
I
F
N
S
L
K
L
I
D
I
V
Y
-
N
K
I
F
P
F
---
V
AES
N
Y
F
I
N
F
S
T
R
----
P
D
H
F
I
G
D
L
K
V
W
N
H
A
E
Q
V
L
K
E
I
L
E
E
S
G
K
P
W
K
L
N
P
G
D
G
A
F
Y
G
P
K
L
D
I
M
V
T
D
H
L
R
K
T
H
Q
V
A
T
I
Q
L
D
F
Q
L
P
E
R
F
D
L
K
F
K
D
Q
D
-
N
S
-
Y
K
R
P
I
M
I
H
R
A
T
F
G
S
I
E
R
F
M
A
L
L
I
D
S
N
E
G
R
W
P
F
W
L
N
P
Y
Q
A
V
I
I
P
V
N
-
T
K
N
V
Q
Q
L
D
M
C
T
A
L
Q
K
K
L
R
N
ELEADDMEPVPLN
D
W
H
F
N
V
D
L
---------------
D
I
R
-
N
E
P
V
G
Y
R
I
K
S
A
I
L
K
N
Y
S
Y
L
I
I
V
G
D
E
E
V
Q
L
Q
K
Y
N
I
R
E
R
D
N
R
K
S
F
E
K
L
T
M
S
Q
I
W
E
K
F
I
E
L
E
K
N
-------
51
PsiBlast_CBE
40.36
38%
-6
- C1 -
-
3UH0
1
SYTM_YEAST
A:
[40-437]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
Q
R
Q
D
L
F
-
M
T
D
P
L
S
P
G
S
M
F
F
L
P
N
G
A
K
I
F
N
K
L
I
E
F
M
K
L
Q
Q
-
K
F
K
F
G
F
N
E
V
V
T
P
L
I
Y
K
K
T
L
W
E
K
S
G
H
W
E
N
Y
A
D
D
M
F
K
V
E
T
--------
E
Y
G
L
K
P
M
N
C
P
G
H
C
L
I
F
G
K
K
D
R
S
Y
N
E
L
P
L
R
F
S
D
F
S
P
L
H
R
N
E
A
S
G
A
L
S
G
L
T
R
L
R
K
F
H
Q
D
D
G
H
I
F
C
T
P
S
Q
V
K
S
E
I
F
N
S
L
K
L
I
D
I
V
Y
N
K
I
-
F
P
F
VAE
S
---
N
Y
F
I
N
F
S
T
R
----
P
D
H
F
I
G
D
L
K
V
W
N
H
A
E
Q
V
L
K
E
I
L
E
E
S
G
K
P
W
K
L
N
P
G
D
G
A
F
Y
G
P
K
L
D
I
M
V
T
D
H
L
R
K
T
H
Q
V
A
T
I
Q
L
D
F
Q
L
P
E
R
F
D
L
K
F
K
D
Q
D
-
N
S
-
Y
K
R
P
I
M
I
H
R
A
T
F
G
S
I
E
R
F
M
A
L
L
I
D
S
N
E
G
R
W
P
F
W
L
N
P
Y
Q
A
V
I
I
P
V
N
-
T
K
N
---
V
Q
Q
L
D
M
C
T
A
L
Q
K
K
L
R
------------
N
E
L
E
A
D
D
MEPVPLN
D
W
H
F
N
V
D
L
D
I
R
-
N
E
P
V
G
Y
R
I
K
S
A
I
L
K
N
Y
S
Y
L
I
I
V
G
D
E
E
V
Q
L
Q
K
Y
N
I
R
E
R
D
N
R
----------------------------
48
PsiBlast_CBE
38.20
38%
5
- C1 -
-
4YYE
1
SYTM_YEAST
A:
[40-437]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
Q
R
Q
D
L
F
-
M
T
D
P
L
S
P
G
S
M
F
F
L
P
N
G
A
K
I
F
N
K
L
I
E
F
M
K
L
Q
Q
-
K
F
K
F
G
F
N
E
V
V
T
P
L
I
Y
K
K
T
L
W
E
K
S
G
H
W
E
N
Y
A
D
D
M
F
K
V
E
T
T
D
E
--
E
K
E
E
Y
G
L
K
P
M
N
C
P
G
H
C
L
I
F
G
K
K
D
R
S
Y
N
E
L
P
L
R
F
S
D
F
S
P
L
H
R
N
E
A
S
G
A
L
S
G
L
T
R
L
R
K
F
H
Q
D
D
G
H
I
F
C
T
P
S
Q
V
K
S
E
I
F
N
S
L
K
L
I
D
I
V
Y
N
K
I
-
F
P
----
S
---
N
Y
F
I
N
F
S
T
R
----
P
D
H
F
I
G
D
L
K
V
W
N
H
A
E
Q
V
L
K
E
I
L
E
E
S
G
K
P
W
K
L
N
P
G
D
G
A
F
Y
G
P
K
L
D
I
M
V
T
D
H
L
R
K
T
H
Q
V
A
T
I
Q
L
D
F
Q
L
P
E
R
F
D
L
K
F
K
D
Q
D
-
N
S
-
Y
K
R
P
I
M
I
H
R
A
T
F
G
S
I
E
R
F
M
A
L
L
I
D
S
N
E
G
R
W
P
F
W
L
N
P
Y
Q
A
V
I
I
P
V
N
-
T
K
N
---
V
Q
Q
L
D
M
C
T
A
L
Q
K
K
L
R
------------
N
E
L
E
A
D
D
MEPVPLN
D
W
H
F
NVDL
D
I
R
-
N
E
P
V
G
Y
R
I
K
S
A
I
L
K
N
Y
S
Y
L
I
I
V
G
D
E
E
V
Q
L
Q
K
Y
N
I
R
E
R
D
N
R
----------------------------