@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VL28: (2017-10-31 )
MALIVQKYGGTSMGTPERILNVARRVKRWHDHGHKVVVVVSAMSGETNRLLALAKAITETPDPREIDQMVSTGEQVTISMLAMALNSIGVEAKSYTGRQVGIKTDSAFTKARIESIDTDVMTNDLDAGRVIVVAGFQGFDANGNTTTLGRGGSDTSGVAIAAALKADECQIYTDVDGVYTTDPRVAPKAKKIDRISFEEMLEMASLGSKVLQIRSVEFAGKYQVPLRVLSSFDNDDDGAFDDEFKENVGTLITTEAEDTMEQPIIAGIAFNRDEAKLTILGVPDEPGIASKILSPVSDANIEVDMIVQNVEEDGTTDFTFTVNRVDLAKAEKILNETAKNIGAREVSTRDDIVKVSIVGVGMRSHAGVASKMFTALADEGINILMISTSEIKVSVIIDEKYLELAVRCLHTAFGLDREHGESSARA
Atome Classification :
(22 SA)
.........10........20........30........40........50...------------------------....---------------------------------------------------------.-----------------------------------------------60---------------------------------------------------------.....---------------------------------...70........80........90........100.......110....-.-.-----.120.......130.......140.-......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250......------.260.......270.......280.--....--....290.......300.......310--.--.......320.......-330..-..----.-----..340-.---..---------.-------.....350.......360.......370.......380.....--.--.390.......400.......410.......420....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
A
L
I
V
QKYGGTSMG
T
P
E
R
I
L
N
V
A
R
R
V
K
R
W
H
DHG
H
K
V
V
V
V
V
S
AMSGE
T
N
R
L
L
A
L
A
------------------------
K
A
I
T---------------------------------------------------------E-----------------------------------------------TP---------------------------------------------------------
D
P
R
E
I
---------------------------------
D
Q
M
VSTGE
Q
V
T
I
S
M
L
A
M
A
L
N
S
IGVEAKSYTG
R
Q
VGIKTDS
A
F
T
K
A
R
I
E
SI-D-T-----DVMTNDLDAG
R
V
I
V
V
AGFQGFDANG-N
T
T
TLGRGGSDTS
G
V
A
I
A
A
A
LKAD
E
C
Q
I
Y
T
DVD
G
V
YTTDPRVAPK
A
K
KIDRI
S
F
E
E
M
L
E
M
A
S
L
G
S
K
V
L
Q
I
R
S
V
E
FAGKY
Q
V
P
L
R
V
L
S
SFDNDDDGAF
D
D
E
F
K
ENVG
T
L
I
TTE
A
E
D
------
T
M
EQP
I
I
A
G
I
A
FNRDE
A
K
L
T
I
L
--G--VPDE--P
G
I
A
S
K
I
LSPVSDAN
I
E
V
D
M
I
V
Q
N
V
-E--E--DGTT
D
F
T
F
T
VN
R
V
D
L
A
K
-
A
E
K
I
L
-
N
E
----
T
-----
A
K
N---I---GA---------R-------EVSTRD
D
I
V
K
V
S
I
V
G
V
GMRSHA
G
V
A
S
K
M
F
T
A
L
A
DEG
I
N
I
L
M
I
S--T--S
E
I
K
V
S
V
I
I
D
E
K
Y
L
E
L
A
V
R
C
L
H
T
A
FGL
D
R
EHGESSARA
81
HHSearch
83.63
49%
-76
- C2 -
-
3AAW
4
AK_CORGL
C:
[1-409]
M
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
E
L
A
------------------------
A
A
V
N
---------------------------------------------------------
P
-----------------------------------------------
V
P
---------------------------------------------------------
P
A
R
E
M
---------------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
G
S
Q
---------------
D
V
-
T
-
P
-----
G
R
V
R
E
A
L
D
E
G
K
I
C
I
V
A
G
F
Q
G
V
N
K
-
R
-
D
V
T
T
L
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
N
D
------------
P
G
T
L
I
A
G
S
M
E
D
I-----
P
V
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
--
G
--
I
S
D
K
--
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
-
S
--
S
VE
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
R
R
-
A
M
E
I
L
-
K
K
----
L
-----
Q
V
Q
---
G
---
N
W
---------
T
-------
N
V
L
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
---------
2
PsiBlast_PDB
81.54
44%
-88
- C2 -
-
3L76
4
?
A:
[2-421]
-
A
L
I
V
Q
K
F
G
G
T
S
V
G
T
V
E
R
I
Q
A
V
A
Q
R
I
K
R
T
V
Q
G
G
N
S
L
V
V
V
V
S
A
M
G
K
S
T
D
V
L
V
D
L
A
------------------------
Q
Q
I
S
---------------------------------------------------------
P
-----------------------------------------------
N
P
---------------------------------------------------------
C
R
R
E
M
---------------------------------
D
M
L
L
S
T
G
E
Q
V
S
I
A
L
L
S
L
A
L
Q
E
I
D
Q
P
A
I
S
L
T
G
A
Q
V
G
I
V
T
E
-------
I
L
E
I
-
R
-
P
-----
D
R
L
E
H
H
L
R
E
G
K
V
V
V
V
A
G
F
Q
G
I
--
H
L
-
E
I
T
T
L
G
R
G
G
S
D
T
S
A
V
A
L
A
A
A
L
K
A
D
F
C
E
I
Y
T
D
V
P
G
I
L
T
T
D
P
R
L
V
P
E
A
Q
L
M
A
E
I
T
C
D
E
M
L
E
L
A
S
L
G
A
K
V
L
H
P
R
A
V
E
I
A
R
N
Y
G
I
P
L
V
V
R
S
S
W
S
D
E
P
G
T
K
V
V
A
P
P
V
Q
N
-
R
S
L
V
G
L
E
I
A
K
------
A
V
D
-----
G
V
E
Y
D
A
D
Q
A
K
V
A
L
L
--
R
--
V
P
D
R
--
P
G
V
A
S
K
L
F
R
D
I
A
Q
Q
Q
V
D
I
D
L
I
I
Q
S
I
-
H
--
D
--
G
N
S
N
D
I
A
F
T
V
V
K
D
L
L
N
T
-
A
E
A
V
T
-
S
A
----
I
-----
A
P
A
---
L
---
R
S
---------
Y
PEADQEA
E
I
I
V
E
K
G
I
A
K
I
A
I
A
G
A
G
M
I
G
R
P
G
I
A
A
K
M
F
K
T
L
A
D
V
G
V
N
I
E
M
I
S
--
T
--
S
E
V
K
V
S
C
V
I
D
Q
R
D
A
D
R
A
I
A
A
L
S
N
A
F
G
V
-----------
21
PsiBlast_CBE
80.95
47%
-66
- C2 -
-
3AB2
5
AK_CORGL
O:
[2-410]
-
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
E
L
A
------------------------
A
A
V
N
---------------------------------------------------------
P
-----------------------------------------------
V
P
---------------------------------------------------------
P
A
R
E
M
---------------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
G
S
Q
A
G
V
L
T
-------------
T
-
P
-----
G
R
V
R
E
A
L
D
E
G
K
I
C
I
V
A
G
F
Q
------------
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
N
D
P
------------
G
T
L
I
A
G
S
M
E
D
I-----
P
V
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
--
G
--
I
S
D
K
--
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
-
S
SV
E
--
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
R
R
-
A
M
E
I
L
-
K
K
----
L
-----
Q
V
Q
---
G
---
N
W
---------
T
-------
N
V
L
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
E
--------
22
PsiBlast_CBE
80.42
47%
-71
- C2 -
-
3AB2
2
AK_CORGL
E:
[2-408]
-
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
E
L
A
------------------------
A
A
V
N
---------------------------------------------------------
P
-----------------------------------------------
V
P
---------------------------------------------------------
P
A
R
E
M
---------------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
G
S
Q
A
G
V
L
T
-----------
V
-
T
-
P
-----
G
R
V
R
E
A
L
D
E
G
K
I
C
I
V
A
G
F
Q
-------------
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
N
D
P
------------
G
T
L
I
A
G
S
M
E
D
I-----
P
V
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
--
G
--
I
S
D
K
--
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
-
S
SV
E
--
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
R
R
-
A
M
E
I
L
-
K
K
----
L
-----
Q
V
Q
---
G
---
N
W
---------
T
-------
N
V
L
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
----------
29
PsiBlast_CBE
80.14
47%
-81
- C2 -
-
3AB4
3
?
E:
[2-409]
-
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
E
L
A
------------------------
A
A
V
N
---------------------------------------------------------
P
-----------------------------------------------
V
P
---------------------------------------------------------
P
A
R
E
M
---------------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
G
--------------------
T
-
P
-----
G
R
V
R
E
A
L
D
E
G
K
I
C
I
V
A
G
F
------------
L
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
N
D
P
------------
G
T
L
I
A
G
S
M
E
D
I-----
P
V
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
--
G
--
I
S
D
K
--
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
----------
T
T
D
I
T
F
T
C
P
R
S
D
G
R
R
-
A
M
E
I
L
-
K
K
----
L
-------
Q
---
G
---
N
W
---------
T
-------
N
V
L
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
---------
83
HHSearch
80.05
46%
-69
- C2 -
-
3L76
4
?
A:
[2-423]
-
A
L
I
V
Q
K
F
G
G
T
S
V
G
T
V
E
R
I
Q
A
V
A
Q
R
I
K
R
T
V
Q
G
G
N
S
L
V
V
V
V
S
A
M
G
K
S
T
D
V
L
V
D
L
A
------------------------
Q
Q
I
S
---------------------------------------------------------
P
-----------------------------------------------
N
P
---------------------------------------------------------
C
R
R
E
M
---------------------------------
D
M
L
L
S
T
G
E
Q
V
S
I
A
L
L
S
L
A
L
Q
E
I
D
Q
P
A
I
S
L
T
G
A
Q
V
G
I
V
T
E
-------
I
L
E
I
-
R
-
P
-----
D
R
L
E
H
H
L
R
E
G
K
V
V
V
V
A
G
F
Q
G
I
--
H
L
-
E
I
T
T
L
G
R
G
G
S
D
T
S
A
V
A
L
A
A
A
L
K
A
D
F
C
E
I
Y
T
D
V
P
G
I
L
T
T
D
P
R
L
V
P
E
A
Q
L
M
A
E
I
T
C
D
E
M
L
E
L
A
S
L
G
A
K
V
L
H
P
R
A
V
E
I
A
R
N
Y
G
I
P
L
V
V
R
S
S
W
S
D
E
------------
P
G
T
K
V
V
A
P
P
V
Q
NRSLVG
L
E
I
A
K
A
V
D
G
V
E
Y
D
A
D
Q
A
K
V
A
L
L
--
R
--
V
P
D
R
--
P
G
V
A
S
K
L
F
R
D
I
A
Q
Q
Q
V
D
I
D
L
I
I
Q
S
I
-
H
--
D
--
G
N
S
N
D
I
A
F
T
V
V
K
D
L
L
N
T
-
A
E
A
V
T
-
S
A
I
APA
L
-----
R
S
Y
PEA
D
---
Q
E
---------
A
-------
E
I
I
V
E
K
G
I
A
K
I
A
I
A
G
A
G
M
I
G
R
P
G
I
A
A
K
M
F
K
T
L
A
D
V
G
V
N
I
E
M
I
S
--
T
--
S
E
V
K
V
S
C
V
I
D
Q
R
D
A
D
R
A
I
A
A
L
S
N
A
F
G
V
T
L
---------
30
PsiBlast_CBE
79.97
47%
-79
- C2 -
-
3AB4
3
?
C:
[2-409]
-
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
E
L
A
------------------------
A
A
V
N
---------------------------------------------------------
P
-----------------------------------------------
V
P
---------------------------------------------------------
P
A
R
E
M
---------------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
---------------------
T
-
P
-----
G
R
V
R
E
A
L
D
E
G
K
I
C
I
V
A
-----------------
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
N
D
P
------------
G
T
L
I
A
G
S
M
E
D
I-----
P
V
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
--
G
--
I
S
D
K
--
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
-------
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
R
R
-
A
M
E
I
L
-
K
K
----
L
-----
Q
V
Q
---
G
---
N
W
---------
T
-------
N
V
L
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
---------
23
PsiBlast_CBE
79.63
47%
-39
- C2 -
-
3AAW
4
AK_CORGL
C:
[1-409]
M
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
E
L
A
------------------------
A
A
V
N
---------------------------------------------------------
P
-----------------------------------------------
V
P
---------------------------------------------------------
P
A
R
E
M
---------------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
G
S
Q
---------------
D
V
-
T
-
P
-----
G
R
V
R
E
A
L
D
E
G
K
I
C
I
V
A
G
F
Q
G
V
N
K
--R
D
V
T
T
L
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
N
D
P
------------
G
T
L
I
A
G
S
M
E
D
I-----
P
V
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
--
G
--
I
S
D
K
--
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
-
S
SV
E
--
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
R
R
-
A
M
E
I
L
-
K
K
----
L
-----
Q
V
Q
---
G
---
N
W
---------
T
-------
N
V
L
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
---------
24
PsiBlast_CBE
79.13
47%
-85
- C2 -
-
3AB4
13
?
O:
[2-407]
-
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
E
L
A
------------------------
A
A
V
N
---------------------------------------------------------
P
-----------------------------------------------
V
P
---------------------------------------------------------
P
A
R
E
M
---------------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
------------------
D
V
-
T
-
P
-----
G
R
V
R
E
A
L
D
E
G
K
I
C
I
V
A
----------------
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
N
D
P
------------
G
T
L
I
A
G
S
M
E
D
I-----
P
V
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
--
G
--
I
S
D
K
--
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
--------
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
R
R
-
A
M
E
I
L
-
K
K
------------
Q
---
G
---
N
W
---------
T
-------
N
V
L
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
-----------
1
PsiBlast_PDB
77.45
47%
-45
- C2 -
-
3AAW
3
AK_CORGL
A:
[2-409]
-
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
E
L
A
------------------------
A
A
V
N
---------------------------------------------------------
P
-----------------------------------------------
V
P
---------------------------------------------------------
P
A
R
E
M
---------------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
-------------------
V
-
T
-
P
-----
G
R
V
R
E
A
L
D
E
G
K
I
C
I
V
A
G
F
--
V
N
K
E
T
R
D
V
T
T
L
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
N
D
P
------------
G
T
L
I
A
G
S
M
E
D
I-----
P
V
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
--
G
--
I
S
D
K
--
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
-
S
SV
E
--
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
R
R
-
A
M
E
I
L
-
K
K
----
L
-----
Q
V
Q
---
G
---
N
W
---------
T
-------
N
V
L
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
---------
28
PsiBlast_CBE
77.04
47%
-75
- C2 -
-
3AB4
1
?
G:
[2-407]
-
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
E
L
A
------------------------
A
A
V
N
---------------------------------------------------------
P
-----------------------------------------------
V
P
---------------------------------------------------------
P
A
R
E
M
---------------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
------------------------------
R
V
R
E
A
L
D
E
G
K
I
C
I
V
A
-----------------
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
N
D
P
------------
G
T
L
I
A
G
S
M
E
D
I-----
P
V
--
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
--
G
--
I
S
D
K
--
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
F--------
T
T
D
I
T
F
T
C
P
R
S
D
G
R
R
-
A
M
E
I
L
-
K
K
----
L
-----
Q
V
Q
--------
W
---------
T
-------
N
V
L
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
-----------
80
HHSearch
74.89
38%
4
- C2 -
-
3C1M
3
AK_METJA
D:
[2-470]
--
T
T
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
S
------------------------
Q
Q
A
L
DVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYL
G
-----------------------------------------------
E
L
---------------------------------------------------------
T
P
K
S
R
---------------------------------
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
V
K
-----
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
-----------
S
E
G
T
L
I
T
N
D
M
E
--------
M
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
--
G
--
A
G
M
V
GV
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
S
-
S
--
E
--
T
---
N
I
S
L
V
V
S
E
E
D
V
D
K
-
A
L
K
A
L
-
K
R
----
E
-----
F
G
D
KSF
L
NNN
L
I
---------
R
-------
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
----------
82
HHSearch
74.24
38%
1
- C2 -
-
2HMF
2
AK_METJA
B:
[1-468]
--
T
T
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
S
------------------------
Q
Q
A
L
DVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYL
G
-----------------------------------------------
E
L
---------------------------------------------------------
T
P
K
S
R
---------------------------------
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
V
K
-----
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
-----------
S
E
G
T
L
I
T
N
D
M
E
--------
M
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
--
G
--
A
G
M
V
GV
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
S
-
S
--
E
--
T
---
N
I
S
L
V
V
S
E
E
D
V
D
K
-
A
L
K
A
L
-
K
R
----
E
-----
F
G
D
F--
L
NNN
L
I
---------
R
-------
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
-----------
67
Fugue
72.70
37%
3
- C2 -
-
3C1M
6
AK_METJA
A:
[2-470]
--
T
T
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
S
------------------------
Q
Q
A
L
---------------------------------------------------------
D
-----------------------------------------------
V
R
D
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
E
A
I
KS
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
I
G
V
A
Y
L
GEL
T
P
K
S
R
---------------------------------
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
E
V
-
K
-----
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
-----------
T
L
I
T
N
D
M
E
M
------
S
--
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
--
G
AG
M
V
G
V
--
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
--------
S
S
E
T
N
I
S
L
V
V
S
E
E
D
V
D
K
-
A
L
K
A
L
-
K
R
----
E
FGDSF
L
N
N
---
N
---
L
I
---------
R
-------
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
--
Q
GS
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
----------
36
PsiBlast_CBE
70.63
32%
-11
- C2 -
-
3C1N
3
AK_METJA
B:
[4-467]
----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
S
Q
Q
A
L
D
VRD
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
---------------------------------------------------------
E
-----------------------------------------------
A
I
---------------------------------------------------------
K
S
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
I
G
V
A
Y
L
GELT
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
-
V
K----
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
-----------
G
T
L
I
T
N
D
-----------
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
A
G
--
M
V
G
V
--
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
S
-
S
--
E
-----
T
N
I
S
L
V
V
S
E
E
D
V
D
K
-
A
L
K
A
L
-
K
R
----
E
-----
F
G
D
---------LNNNLI---
R
-------
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
-------------
37
PsiBlast_CBE
70.20
32%
2
- C2 -
-
3C1M
3
AK_METJA
D:
[4-467]
----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
S
QQALDVRDIAKVGDFIKFIREKHY
K
A
I
E
---------------------------------------------------------
E
-----------------------------------------------
A
I
---------------------------------------------------------
K
S
E
E
I
KEEVKKIIDSRIEELEKVLIGVAYLGELTPKSR
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
-
V
K----
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
-----------
G
T
L
I
T
N
D
M
E
--------
M
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
GA
G
--
M
V
G
V
--
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
S
-
S
--
E
-----
T
N
I
S
L
V
V
S
E
E
D
V
D
K
-
A
L
K
A
L
-
K
R
----
E
-----
F
G
D
---------KSFLNNNLI
R
-------
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
-------------
39
PsiBlast_CBE
70.18
32%
-1
- C2 -
-
3C1M
2
AK_METJA
B:
[4-467]
----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
S
QQALDVRDIAKVGDFIKFIREKHY
K
A
I
E
---------------------------------------------------------
E
-----------------------------------------------
A
I
---------------------------------------------------------
K
S
E
E
I
KEEVKKIIDSRIEELEKVLIGVAYLGELTPKSR
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
-
V
K----
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
-----------
G
T
L
I
T
N
D
M
E
--------
M
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
GA
G
--
M
V
G
V
--
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
S
-
S
--
E
-----
T
N
I
S
L
V
V
S
E
E
D
V
D
K
-
A
L
K
A
L
-
K
R
----
E
-----
F
G
D
---------SFLNNNLI-
R
-------
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
-------------
6
PsiBlast_PDB
69.88
32%
-0
- C2 -
-
3C1M
6
AK_METJA
A:
[4-467]
----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
S
Q
Q
A
L
DVRD
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
---------------------------------------------------------
E
-----------------------------------------------
A
I
---------------------------------------------------------
K
S
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
I
G
V
A
Y
L
GELT
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
-
V
K----
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
-----------
G
T
L
I
T
N
D
M
E
--------
M
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
A
G
--
M
V
G
V
--
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
S
-
S
--
E
-----
T
N
I
S
L
V
V
S
E
E
D
V
D
K
-
A
L
K
A
L
-
K
R
----
E
-----
F
G
D
---------SFLNNNLI-
R
-------
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
-------------
34
PsiBlast_CBE
69.36
32%
-3
- C2 -
-
3C20
3
AK_METJA
B:
[4-467]
----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
S
QQALDVRDIAKVGDFIKFIREKHY
K
A
I
E
---------------------------------------------------------
E
-----------------------------------------------
A
I
---------------------------------------------------------
K
S
E
E
I
KEEVKKIIDSRIEELEKVLIGVAYLGELTPKSR
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
-
V
K----
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
-----------
G
T
L
I
T
N
D
M
E
--------
M
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
GA
G
--
M
V
G
V
--
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
S
-
S
--
E
-----
T
N
I
S
L
V
V
S
E
E
D
V
D
K
-
A
L
K
A
L
-
K
R
----
E
-----
F
G
D
---------KSFLNNNLI
R
-------
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
-------------
31
PsiBlast_CBE
69.34
32%
3
- C2 -
-
2HMF
2
AK_METJA
D:
[3-466]
----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
S
QQALDVRDIAKVGDFIKFIREKHY
K
A
I
E
---------------------------------------------------------
E
-----------------------------------------------
A
I
---------------------------------------------------------
K
S
E
E
I
KEEVKKIIDSRIEELEKVLIGVAYLGELTPKSR
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
-
V
K----
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
-----------
G
T
L
I
T
N
D
M
E
--------
M
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
GA
G
--
M
V
G
V
--
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
S
-
S
--
E
-----
T
N
I
S
L
V
V
S
E
E
D
V
D
K
-
A
L
K
A
L
-
K
R
----
E
-----
F
G
D
---
F
-----LNNNLI---
R
-------
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
-------------
5
PsiBlast_PDB
69.22
32%
1
- C2 -
-
3C20
3
AK_METJA
A:
[4-467]
----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
S
Q
Q
A
L
D
VRD
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
---------------------------------------------------------
E
-----------------------------------------------
A
I
---------------------------------------------------------
K
S
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
I
G
V
A
Y
L
GELT
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
-
V
K----
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
-----------
G
T
L
I
T
N
D
M
E
--------
M
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
A
G
--
M
V
G
V
--
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
S
-
S
--
E
-----
T
N
I
S
L
V
V
S
E
E
D
V
D
K
-
A
L
K
A
L
-
K
R
----
E
-----
F
G
D
---------SFLNNNLI-
R
-------
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
-------------
79
HHSearch
63.84
30%
-8
- C2 -
-
2J0W
2
AK3_ECOLI
A:
[3-448]
-
E
I
V
V
S
K
F
G
G
T
S
V
A
D
F
D
A
M
N
R
S
A
D
I
V
L
S
D
---
A
N
V
R
L
V
V
L
S
A
S
A
G
I
T
N
L
L
V
A
L
A
------------------------
E
G
L
E
---------------------------------------------------------
P
G
E
R
F
E
K
L
D
A
I
R
N
I
Q
F
A
I
L
E
R
LRYP
N
V
I
R
E
E
I
E
R
L
L
E
N
I
T
V
L
A
E
A
A
A
L
A
T
---------------------------------------------------------
S
P
A
L
T
---------------------------------
D
E
L
V
S
H
G
E
L
M
S
T
L
L
F
V
E
I
L
R
E
R
D
V
Q
A
Q
W
F
D
V
R
K
V
-
M
R
T
N
D
R
F
G
R
A
E
P
D
I
A
-
A
-
L
A
E
L
A
A
L
Q
L
L
P
R
L
N
-
E
G
L
V
I
T
Q
G
F
I
G
S
E
N
K
G
-
R
T
T
T
L
G
R
G
G
S
D
Y
T
A
A
L
L
A
E
A
L
H
A
S
R
V
D
I
W
T
D
V
P
G
I
Y
T
T
D
P
R
V
V
S
A
A
K
R
I
D
E
I
A
F
A
E
A
A
E
M
A
T
F
G
A
K
V
L
H
P
A
T
L
L
P
A
V
R
S
D
I
P
V
F
V
G
S
S
K
D
P
R
-----------
A
G
G
T
L
V
C
N
K
T
E
---------
N
P
P
L
F
R
A
L
A
L
R
R
N
Q
T
L
L
T
L
H
--
S
--
L
N
M
L
HS
R
G
F
L
A
E
V
F
G
I
L
A
R
H
N
I
S
V
D
L
I
T
T
S
E
-
V
---------
S
V
A
L
T
L
D
T
T
G
S
T
S
T
G
D
T
L
L
T
Q
S
----
L
-----
L
M
E
---
L
S
--
A
L
---------
C
-------
R
V
E
V
E
E
G
L
A
L
V
A
L
I
G
N
D
L
S
K
A
C
G
V
G
K
E
V
F
G
V
L
E
P
--
F
N
I
R
M
I
C
Y
G
A
--
S
S
H
N
L
C
F
L
V
P
G
E
D
A
E
Q
V
V
Q
K
L
H
S
N
L
F
------------