@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VL69: (2017-10-31 )
MRAYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSKGFPLLTTKKVHFRSIVIELLWFLKGDTNVKYLQDNKVTIWDEWATAEQTARFGRPEHELGPVYGHQWRNFGATKNADGTYNQDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDNKLSCQLYQRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDIHLYANHFEQAKLQLMREPLPLCQLKLNPDVKDIFDFKFEDIEIVGYESHPAIKAPVAV
Atome Classification :
(100 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40.........50........60........70........80.......---.---90.-----------------------------------------.-----------------------------------------.---.---....100.......110.-.-.---------------------------....120.......130.......140.......150.......160.......170--........180.......190.......200.......210.......220.......230.......240.......250-----------.......260.......270.......280
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
R
A
Y
L
D
L
L
Q
H
I
L
DNGGDKGDRTGTGTRSVFGH
Q
M
R
F
DLSK-GFPLLTTK
K
V
H
F
R
S
I
V
I
E
L
L
W
F
LKGDTN
V
K
Y
L
QDN
K
V
T
I
W
DEWA
T
A
E
Q
---
T
---
A
RF-----------------------------------------G-----------------------------------------R---P---EHELGPVYGHQWRNFGAT-K-N---------------------------ADGTYNQ
D
G
F
D
Q
I
K
W
L
I
N
E
I
KTNPNS
R
R
L
I
V
SGWNPNEAG
Q
V
ALP
P
C
H
T
L
F
Q
F
F
V-Q--DNK
L
S
C
Q
L
Y
QRSA
D
V
F
L
GV
P
F
N
I
A
S
Y
A
L
L
T
H
M
I
A
Q
V
CGLGV
G
D
F
V
WTGG
D
I
H
L
Y
A
N
H
F
E
Q
A
K
L
Q
L
M
REPL
P
L
C
Q
L
K
LNP
D
V
-----------
K
D
I
F
DFKFE
D
I
E
I
V
GYESHPAIKAPVAV
11
PsiBlast_PDB
93.33
60%
-145
- C6 -
-
1AXW
3
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
10
PsiBlast_PDB
93.26
60%
-144
- C6 -
-
1AN5
1
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
9
PsiBlast_PDB
93.20
60%
-141
- C6 -
-
1TDU
3
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
128
HHSearch
93.11
61%
-147
* C6 *
-
4FOX
3
TYSY_MYCTU
D:
[1-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
D
R
T
G
T
G
T
R
S
L
F
G
Q
Q
M
R
Y
D
L
S
A
-
G
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
S
D
-------------------------------------------------------------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
A
------------------------------------
P
S
G
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
L
A
D
R
------------
D
S
I
F
E
Y
T
Y
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
V
A
V
7
PsiBlast_PDB
93.02
60%
-146
- C6 -
-
1TSD
5
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
3
PsiBlast_PDB
93.02
60%
-147
- C6 -
-
2KCE
3
TYSY_ECOLI
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
15
PsiBlast_PDB
92.96
60%
-148
- C6 -
-
1TRG
2
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
6
PsiBlast_PDB
92.90
60%
-145
- C6 -
-
1TLC
3
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
30
PsiBlast_CBE
92.86
60%
-143
- C6 -
-
2TSC
3
TYSY_ECOLI
B:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
A
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
1
PsiBlast_PDB
92.72
63%
-185
- C6 -
-
3IX6
-
TYSY_BRUME
A:
[1-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
T
Y
L
D
L
L
Q
H
V
L
D
H
G
V
D
R
D
D
----
G
T
R
S
V
F
G
Y
Q
M
R
F
D
L
E
E
-
G
F
P
V
L
---
K
L
H
L
R
S
I
I
H
E
L
L
W
F
L
K
G
D
T
N
I
A
Y
L
K
E
N
G
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
Y
Q
W
R
S
W
P
A
--------------------------------
P
D
G
R
H
----
I
D
Q
I
A
N
L
L
K
M
L
H
T
N
P
Q
S
R
R
L
I
V
S
A
W
N
P
A
L
V
D
E
M
A
L
P
P
C
H
C
L
F
Q
F
Y
V
-
A
--
N
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
I
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
M
M
I
A
Q
V
T
G
L
K
P
G
E
F
I
H
T
L
G
D
A
H
I
Y
S
N
H
F
E
Q
A
R
L
Q
L
T
R
T
P
K
K
L
P
V
M
H
I
N
P
D
V
-----------
K
D
L
F
A
F
R
F
E
D
F
R
L
D
G
-------------
129
HHSearch
92.61
61%
-145
- C6 -
-
4FQS
3
TYSY_MYCTU
A:
[1-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
D
R
T
G
T
G
T
R
S
L
F
G
Q
Q
M
R
Y
D
L
S
A
-
G
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
S
D
-------------------------------------------------------------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
A
------------------------------------
P
S
G
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
L
A
D
R
------------
D
S
I
F
E
Y
T
Y
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
V
A
V
118
HHSearch
92.23
63%
-145
- C6 -
-
1TJS
-
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
-------------------------------------------------------------------------------------------------------
N
G
D
L
G
P
V
Y
G
K
Q
W
R
A
W
P
T
------------------------------------
P
D
G
R
H
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
17
PsiBlast_PDB
92.23
60%
-143
- C6 -
-
2TSC
3
TYSY_ECOLI
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
A
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
2
PsiBlast_PDB
92.19
60%
-141
- C6 -
-
2BBQ
3
TYSY_ECOLI
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
104
Fugue
92.15
52%
0
- C- -
-
1QZF
5
?
A:
[3-521]
E
K
N
V
S
I
V
V
A
A
S
VLSSGIGINGQLPWSI
S
E
D
L
K
F
F
S
K
I
T
N
NKCDSN
K
K
N
A
L
I
M
G
R
K
T
W
D
S
I
GRRPLKN
R
I
I
V
V
I
S
SSLPQDEADPN
V
V
V
F
RNLEDSIENLMNDDSIENIFVCGG
E
S
I
Y
R
D
A
L
K
D
NFVDRIY
L
T
R
V
ALEDIEFD
T
Y
F
P
EIPETFLPV
Y
M
S
Q
T
FCTKN
I
S
Y
D
F
M
I
F
E
KQEKKTLQNCDPARGQL
K
S
I
D
D
T
V
D
L
L
G
E
I
F
GIRK
M
G
N
R
H
KFPKEEIYNTPSIRFGREHY
E
F
Q
Y
L
D
L
L
S
R
V
L
E
N
G
A
Y
R
E
N
R
T
G
I
S
T
Y
S
I
F
G
Q
M
M
R
F
D
M
R
E
-
S
F
P
L
L
T
T
K
K
V
A
I
R
S
I
F
E
E
L
I
W
F
I
K
G
D
T
N
G
N
H
L
I
E
K
K
V
Y
I
W
S
G
N
G
S
K
E
Y
---
L
---
E
R
I
-----------------------------------------
G
LGH--------------------------------------
R
---
E
---
E
N
D
L
G
P
I
Y
G
F
Q
W
R
H
Y
N
G
E
Y
K
-
T
---------------------------
M
H
D
D
Y
T
G
V
G
V
D
Q
L
A
K
L
I
E
T
L
K
N
N
P
K
D
R
R
H
I
L
T
A
W
N
P
S
A
L
S
Q
M
A
L
P
P
C
H
V
L
S
Q
Y
Y
V
T
N
--
D
N
C
L
S
C
N
L
Y
Q
R
S
C
D
L
G
L
G
S
P
F
N
I
A
S
Y
A
I
L
T
M
M
L
A
Q
V
C
G
Y
E
P
G
E
L
A
I
F
I
G
D
A
H
I
Y
E
N
H
L
T
Q
L
K
E
Q
L
S
R
T
P
R
P
F
P
Q
L
K
F
K
R
K
V
-----------
E
N
I
E
D
F
K
W
E
D
I
E
L
I
G
Y
Y
P
Y
P
T
I
K
M
D
M
A
V
8
PsiBlast_PDB
92.10
60%
-140
- C6 -
-
1DDU
3
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
12
PsiBlast_PDB
91.94
60%
-144
- C6 -
-
1BDU
1
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
19
PsiBlast_PDB
91.91
59%
-143
- C6 -
-
3B5B
3
TYSY_ECOLI
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
Q
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
5
PsiBlast_PDB
91.84
60%
-145
- C6 -
-
1AOB
1
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
4
PsiBlast_PDB
91.84
60%
-142
- C6 -
-
3TMS
-
TYSY_ECOLI
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
27
PsiBlast_CBE
91.75
60%
-144
- C6 -
-
1DDU
2
TYSY_ECOLI
B:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
16
PsiBlast_PDB
91.71
60%
-143
- C6 -
-
1SYN
3
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
29
PsiBlast_CBE
91.53
60%
-146
- C6 -
-
1AN5
1
TYSY_ECOLI
B:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
22
PsiBlast_CBE
91.47
60%
-144
- C6 -
-
2BBQ
3
TYSY_ECOLI
B:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
31
PsiBlast_CBE
91.41
59%
-141
- C6 -
-
3B5B
3
TYSY_ECOLI
B:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
Q
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
24
PsiBlast_CBE
91.37
60%
-143
- C6 -
-
1TLC
3
TYSY_ECOLI
B:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
28
PsiBlast_CBE
91.35
60%
-143
- C6 -
-
1AXW
3
TYSY_ECOLI
B:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
13
PsiBlast_PDB
91.34
60%
-147
- C6 -
-
1BID
1
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
21
PsiBlast_CBE
90.89
60%
-143
- C6 -
-
2KCE
3
TYSY_ECOLI
B:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
26
PsiBlast_CBE
90.81
60%
-143
- C6 -
-
1SYN
3
TYSY_ECOLI
B:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
18
PsiBlast_PDB
90.76
59%
-144
- C6 -
-
2VET
2
TYSY_ECOLI
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
Q
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
23
PsiBlast_CBE
90.59
60%
-146
- C6 -
-
1TSD
3
TYSY_ECOLI
B:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
25
PsiBlast_CBE
90.46
60%
-144
- C6 -
-
1TDU
2
TYSY_ECOLI
B:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
125
HHSearch
85.30
60%
-38
- C6 -
-
3UWL
5
TYSY_ENTFA
B:
[2-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
Y
L
A
L
G
K
K
I
L
E
E
G
H
F
K
E
D
R
T
G
T
G
T
Y
S
L
F
G
Y
Q
M
R
F
D
L
A
K
-
G
F
P
L
L
T
T
K
R
V
P
F
G
L
I
K
S
E
L
L
W
F
L
K
G
D
T
N
I
R
Y
L
L
E
R
N
N
H
I
W
D
E
W
A
F
E
R
Y
---
V
---
K
S
A
-----------------------------------------
D
YQGPDMTD
F
G
H
R
V
L
Q
D
P
A
F
A
E
Q
Y
K
E
E
H
Q
K
F
C
D
A
I
L
ND
A
E
F
A
E
---
K
---
Y
G
E
L
G
N
I
Y
G
A
Q
W
R
H
W
E
T
K
------------------------------------
D
G
S
F
I
D
Q
L
A
N
V
I
E
M
I
K
T
N
P
D
S
R
R
L
I
V
S
A
W
N
P
E
D
V
P
S
M
A
L
P
P
C
H
T
M
F
Q
F
Y
V
-
N
--
E
G
K
L
S
C
Q
L
Y
Q
R
S
A
D
V
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
L
I
A
H
E
T
G
L
E
V
G
E
F
V
H
T
L
G
D
A
H
L
Y
Q
N
H
V
E
Q
M
Q
E
Q
L
S
R
E
V
R
S
F
P
T
L
V
L
N
P
D
K
-----------
A
S
V
F
D
F
D
M
E
D
I
K
V
E
G
Y
D
P
H
P
T
I
K
A
P
I
A
V
124
HHSearch
82.05
60%
-32
- C6 -
-
1VZC
1
TYSY_LACCA
A:
[3-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
P
Y
L
D
L
A
K
K
V
L
D
E
G
H
F
K
P
D
R
T
H
T
G
T
Y
S
I
F
G
H
Q
M
R
F
D
L
S
K
-
G
F
P
L
L
T
T
K
K
V
P
F
G
L
I
K
S
Q
L
L
W
F
L
H
G
D
T
N
I
R
F
L
L
Q
H
R
N
H
I
W
D
E
W
A
F
E
K
W
---
V
---
K
S
D
EYHGPDMTDFGHRSQKAPEFA
A
V
Y
H
E
E
M
A
K
F
D
D
R
V
L
H
D
D
A
F
A
-----------------------------------------
A
---
K
---
Y
G
D
L
G
L
V
Y
G
S
Q
W
R
A
W
H
T
S
------------------------------------
K
G
D
T
I
D
Q
L
G
D
V
I
E
Q
I
K
T
H
P
Y
S
R
R
L
I
V
S
A
W
N
P
E
D
V
P
T
M
A
L
P
P
C
H
T
L
Y
Q
F
Y
V
-
N
--
D
G
K
L
S
L
Q
L
Y
Q
R
S
A
D
I
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
L
V
A
H
E
C
G
L
E
V
G
E
F
I
H
T
F
G
D
A
H
L
Y
V
N
H
L
D
Q
I
K
E
Q
L
S
R
T
P
R
P
A
P
T
L
Q
L
N
P
D
K
-----------
H
D
I
F
D
F
D
M
K
D
I
K
L
L
N
Y
D
P
Y
P
A
I
K
A
P
V
A
V
117
HHSearch
80.77
54%
-44
- C6 -
-
4EZ8
4
TYSY_MOUSE
A:
[24-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Q
Y
L
R
Q
V
E
H
I
L
R
C
G
F
K
K
E
D
R
T
G
T
G
T
L
S
V
F
G
M
Q
A
R
Y
S
L
R
D
-
E
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
R
I
W
D
A
N
G
S
R
D
F
---
L
---
D
S
L
-----------------------------------------
G
-----------------------------------------
F
---
S
ARQ
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
-
Y
K
D
---------------------------
M
D
S
D
Y
S
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
-
V
--
N
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
K
I
L
R
K
V
-----------
E
T
I
D
D
F
K
V
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
121
HHSearch
80.70
54%
-41
- C6 -
-
1HVY
4
TYSY_HUMAN
C:
[5-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
D
R
T
G
T
G
T
L
S
V
F
G
M
Q
A
R
Y
S
L
R
D
-
E
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
K
I
W
D
A
N
G
S
R
D
F
---
L
---
D
S
L
-----------------------------------------
G
FST--------------------------------------
R
---
E
---
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
-
Y
-
R
D--------------------------
M
E
S
D
Y
S
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
-
V
--
N
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
114
HHSearch
80.03
49%
-55
- C6 -
-
1J3K
2
?
C:
[45-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
Q
Y
L
N
I
I
Y
D
I
M
M
N
G
N
K
Q
S
D
R
T
G
V
G
V
L
S
K
F
G
Y
I
M
K
F
D
L
S
Q
-
Y
F
P
L
L
T
T
K
K
L
F
L
R
G
I
I
E
E
L
L
W
F
I
R
G
E
T
N
G
N
T
L
L
N
K
N
V
R
I
W
E
A
N
G
T
R
E
F
---
L
---
D
N
R
-----------------------------------------
K
-----------------------------------------
L
---
F
HRE
V
N
D
L
G
P
I
Y
G
F
Q
W
R
H
F
G
A
E
-
Y
T
N
---------------------------
M
Y
D
N
Y
E
N
K
G
V
D
Q
L
K
N
I
I
N
L
I
K
N
D
P
T
S
R
R
I
L
L
C
A
W
N
V
K
D
L
D
Q
M
A
L
P
P
C
H
I
L
C
Q
F
Y
V
-
F
--
D
G
K
L
S
C
I
M
Y
Q
R
S
C
D
L
G
L
G
V
P
F
N
I
A
S
Y
S
I
F
T
H
M
I
A
Q
V
C
N
L
Q
P
A
Q
F
I
H
V
L
G
N
A
H
V
Y
N
N
H
I
D
S
L
K
I
Q
L
N
R
I
P
Y
P
F
P
T
L
K
L
N
P
D
I
-----------
K
N
I
E
D
F
T
I
S
D
F
T
I
Q
N
Y
V
H
H
E
K
I
S
M
D
M
A
A
116
HHSearch
79.96
50%
-53
- C6 -
-
5H39
2
TYSY_HHV8P
A:
[4-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Q
Y
L
R
Q
L
R
E
I
L
C
R
G
S
D
R
L
D
R
T
G
I
G
T
L
S
L
F
G
M
Q
A
R
Y
S
L
R
D
-
H
F
P
L
L
T
T
K
R
V
F
W
R
G
V
V
Q
E
L
L
W
F
L
K
G
S
T
D
S
R
E
L
S
R
T
G
V
K
I
W
D
K
N
G
S
R
E
F
---
L
---
A
G
R
-----------------------------------------
G
-----------------------------------------
L
AHR
R
---
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
A
-
Y
V
D
---------------------------
A
D
A
D
Y
T
G
Q
G
F
D
Q
L
S
Y
I
V
D
L
I
K
N
N
P
H
D
R
R
I
I
M
C
A
W
N
P
A
D
L
S
L
M
A
L
P
P
C
H
L
L
C
Q
F
Y
V
-
A
--
D
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
S
L
L
T
Y
M
L
A
H
V
T
G
L
R
P
G
E
F
I
H
T
L
G
D
A
H
I
Y
K
T
H
I
E
P
L
R
L
Q
L
T
R
T
P
R
P
F
P
R
L
E
I
L
R
S
V
-----------
S
S
M
E
E
F
T
P
D
D
F
R
L
V
D
Y
C
P
H
P
T
I
R
M
E
M
--
115
HHSearch
79.41
49%
-55
- C6 -
-
1J3I
2
?
D:
[45-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
Q
Y
L
N
I
I
Y
D
I
M
M
N
G
N
K
Q
S
D
R
T
G
V
G
V
L
S
K
F
G
Y
I
M
K
F
D
L
S
Q
-
Y
F
P
L
L
T
T
K
K
L
F
L
R
G
I
I
E
E
L
L
W
F
I
R
G
E
T
N
G
N
T
L
L
N
K
N
V
R
I
W
E
A
N
G
T
R
E
F
---
L
---
D
N
R
-----------------------------------------
K
-----------------------------------------
L
---
F
HRE
V
N
D
L
G
P
I
Y
G
F
Q
W
R
H
F
G
A
E
-
Y
T
N
---------------------------
M
Y
D
N
Y
E
N
K
G
V
D
Q
L
K
N
I
I
N
L
I
K
N
D
P
T
S
R
R
I
L
L
C
A
W
N
V
K
D
L
D
Q
M
A
L
P
P
C
H
I
L
C
Q
F
Y
V
-
F
--
D
G
K
L
S
C
I
M
Y
Q
R
S
C
D
L
G
L
G
V
P
F
N
I
A
S
Y
S
I
F
T
H
M
I
A
Q
V
C
N
L
Q
P
A
Q
F
I
H
V
L
G
N
A
H
V
Y
N
N
H
I
D
S
L
K
I
Q
L
N
R
I
P
Y
P
F
P
T
L
K
L
N
P
D
I
-----------
K
N
I
E
D
F
T
I
S
D
F
T
I
Q
N
Y
V
H
H
E
K
I
S
M
D
M
A
A
130
HHSearch
78.39
53%
-38
- C6 -
-
1RTS
3
TYSY_RAT
B:
[24-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Q
Y
L
R
Q
V
E
H
I
M
R
C
G
F
K
K
E
D
R
T
G
T
G
T
L
S
V
F
G
M
Q
A
R
Y
S
L
R
D
-
E
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
R
I
W
D
A
N
G
S
R
D
F
---
L
---
D
S
L
-----------------------------------------
G
-----------------------------------------
F
---
S
ARQ
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
D
-
Y
K
D
---------------------------
M
D
S
D
Y
S
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
-
V
--
N
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
T
I
D
D
F
K
V
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
----
119
HHSearch
74.19
49%
-20
- C6 -
-
5BY6
4
?
B:
[23-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
N
Y
L
N
Q
L
K
D
I
I
D
H
G
V
R
K
N
D
R
T
G
I
G
T
L
S
T
F
G
T
Q
S
R
Y
C
L
R
D
D
I
F
P
L
L
T
T
K
R
V
F
W
R
G
V
V
E
E
L
L
W
F
I
S
G
S
T
N
A
K
Q
L
S
E
K
N
V
N
I
W
D
G
N
S
S
R
E
F
---
L
DSR
G
L
Y
-----------------------------------------
N
-----------------------------------------
Y
---
E
---
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
C
P
-
Y
S
S
---------------------------
M
T
A
D
Y
K
G
K
G
Y
D
Q
L
Q
Q
C
I
K
M
I
R
E
E
P
E
S
R
R
I
I
M
T
A
W
N
P
C
D
L
E
K
V
A
L
P
P
C
H
C
F
V
Q
F
Y
V
-
A
--
D
G
E
L
S
C
Q
M
Y
Q
R
S
A
D
M
G
L
G
V
P
F
N
I
A
S
Y
S
L
L
T
R
M
I
A
H
I
T
S
L
K
P
G
F
F
I
H
T
I
G
D
A
H
V
Y
L
T
H
V
D
A
L
K
V
Q
M
E
R
K
P
R
P
F
P
K
L
K
I
L
R
N
V
-----------
E
N
I
D
D
F
R
A
E
D
F
E
L
I
N
Y
K
P
Y
P
K
I
S
M
P
---
120
HHSearch
73.90
49%
-28
- C6 -
-
5BY6
7
?
A:
[23-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
N
Y
L
N
Q
L
K
D
I
I
D
H
G
V
R
K
N
D
R
T
G
I
G
T
L
S
T
F
G
T
Q
S
R
Y
C
L
R
D
D
I
F
P
L
L
T
T
K
R
V
F
W
R
G
V
V
E
E
L
L
W
F
I
S
G
S
T
N
A
K
Q
L
S
E
K
N
V
N
I
W
D
G
N
S
S
R
E
F
---
L
D
S
R
G
L
Y
-----------------------------------------
N
-----------------------------------------
Y
---
E
---
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
C
P
-
Y
S
S
---------------------------
M
T
A
D
Y
K
G
K
G
Y
D
Q
L
Q
Q
C
I
K
M
I
R
E
E
P
E
S
R
R
I
I
M
T
A
W
N
P
C
D
L
E
K
V
A
L
P
P
C
H
C
F
V
Q
F
Y
V
-
A
--
D
G
E
L
S
C
Q
M
Y
Q
R
S
A
D
M
G
L
G
V
P
F
N
I
A
S
Y
S
L
L
T
R
M
I
A
H
I
T
S
L
K
P
G
F
F
I
H
T
I
G
D
A
H
V
Y
L
T
H
V
D
A
L
K
V
Q
M
E
R
K
P
R
P
F
P
K
L
K
I
L
R
N
V
-----------
E
N
I
D
D
F
R
A
E
D
F
E
L
I
N
Y
K
P
Y
P
K
-------
132
HHSearch
69.74
38%
-22
- C6 -
-
3V8H
5
?
A:
[5-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
D
L
V
R
T
I
L
D
T
G
T
W
Q
S
N
--
G
I
R
T
I
G
I
P
G
A
M
L
R
F
D
L
Q
Q
-
G
F
P
A
V
T
T
K
K
L
A
F
K
S
A
I
G
E
L
V
G
F
L
R
A
T
R
S
A
A
E
F
R
A
L
G
C
K
V
W
D
A
N
A
N
E
N
A
Q
W
L
A
---
N
P
Y
-----------------------------------------
R
-----------------------------------------
R
---
G
---
A
D
D
L
G
D
V
Y
G
V
Q
W
R
R
W
P
G
Y
-
K
-
V
L
DAHA
D
A
Q
I
A
D
A
T
S
R
G
F
R
I
V
A
R
F
E
E
GG
A
D
K
V
L
L
H
K
A
I
D
Q
L
R
D
C
L
D
T
I
V
R
D
P
S
S
R
R
I
L
F
H
G
W
N
P
A
V
L
D
E
I
A
L
P
A
C
H
L
L
Y
Q
F
L
P
-
N
VE
R
R
E
I
S
L
C
L
Y
I
R
S
N
D
V
G
L
G
T
P
F
N
L
A
E
G
A
A
L
L
T
L
V
G
R
L
T
G
Y
S
P
R
W
F
T
Y
F
I
G
D
A
H
I
Y
E
N
Q
L
D
M
L
K
Q
Q
L
E
R
E
P
F
E
S
P
R
L
E
L
A
E
R
V
PDYAKTGKYEP
Q
W
L
E
R
V
E
P
S
D
F
T
L
V
G
Y
R
H
H
---------
91
PsiBlast_CBE
65.11
59%
-23
- C6 -
-
3BFI
1
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
M
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
58
PsiBlast_CBE
64.75
59%
-20
- C6 -
-
1JUT
3
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
79
PsiBlast_CBE
60.84
59%
-25
- C6 -
-
1FWM
1
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
Q
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
72
PsiBlast_CBE
60.41
59%
-22
- C6 -
-
1ZPR
3
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
Q
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
87
PsiBlast_CBE
60.11
59%
-22
- C6 -
-
1AIQ
3
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
E
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
61
PsiBlast_CBE
60.07
59%
-27
- C6 -
-
1JTQ
3
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
32
PsiBlast_CBE
59.84
59%
-25
- C6 -
-
4KNZ
3
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
83
PsiBlast_CBE
59.48
59%
-24
- C6 -
-
4GEV
3
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
W
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
93
PsiBlast_CBE
59.47
59%
-19
- C6 -
-
1TYS
2
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
S
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
57
PsiBlast_CBE
59.35
59%
-27
- C6 -
-
1JUT
3
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
56
PsiBlast_CBE
59.34
59%
-25
- C6 -
-
1KCE
3
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
59
PsiBlast_CBE
59.31
59%
-25
- C6 -
-
1JTU
3
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
54
PsiBlast_CBE
59.31
59%
-27
- C6 -
-
1KZI
4
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
44
PsiBlast_CBE
59.08
59%
-22
- C6 -
-
3BHL
3
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
45
PsiBlast_CBE
59.00
59%
-24
- C6 -
-
3B9H
1
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
80
PsiBlast_CBE
58.85
59%
-24
- C6 -
-
1FWM
1
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
Q
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
52
PsiBlast_CBE
58.81
59%
-24
- C6 -
-
1TLS
3
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
43
PsiBlast_CBE
58.77
59%
-23
- C6 -
-
3BHL
3
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
20
PsiBlast_PDB
58.77
59%
-21
- C6 -
-
1KCE
3
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
84
PsiBlast_CBE
58.74
59%
-25
- C6 -
-
4GEV
3
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
W
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
42
PsiBlast_CBE
58.71
59%
-24
- C6 -
-
3BHR
2
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
85
PsiBlast_CBE
58.67
59%
-24
- C6 -
-
2G8X
1
TYSY_ECOLI
B:
[4-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
W
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
--
64
PsiBlast_CBE
58.57
59%
-25
- C6 -
-
1F4F
1
TYSY_ECOLI
A:
[4-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
--
50
PsiBlast_CBE
58.55
59%
-24
- C6 -
-
2A9W
3
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
77
PsiBlast_CBE
58.51
59%
-25
- C6 -
-
1DNA
3
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
N
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
51
PsiBlast_CBE
58.50
59%
-18
- C6 -
-
1TSN
2
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
86
PsiBlast_CBE
58.47
59%
-24
- C6 -
-
2G8X
1
TYSY_ECOLI
A:
[4-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
W
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
--
74
PsiBlast_CBE
58.46
59%
-22
- C6 -
-
2FTO
2
TYSY_ECOLI
X:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
F
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
94
PsiBlast_CBE
58.44
59%
-26
- C6 -
-
1NCE
3
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
C
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
55
PsiBlast_CBE
58.44
59%
-26
- C6 -
-
1KZI
5
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
81
PsiBlast_CBE
58.34
59%
-28
- C6 -
-
1JG0
3
TYSY_ECOLI
B:
[4-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
A
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
A
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
-
76
PsiBlast_CBE
58.34
59%
-22
- C6 -
-
1DNA
3
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
N
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
33
PsiBlast_CBE
58.34
59%
-24
- C6 -
-
4KNZ
3
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
88
PsiBlast_CBE
58.30
59%
-23
- C6 -
-
1AIQ
3
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
E
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
70
PsiBlast_CBE
58.29
59%
-27
- C6 -
-
2VF0
3
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
Q
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
78
PsiBlast_CBE
58.14
59%
-27
- C6 -
-
1BJG
2
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
N
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
92
PsiBlast_CBE
57.99
59%
-22
- C6 -
-
3BGX
2
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
S
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
67
PsiBlast_CBE
57.98
59%
-25
- C6 -
-
1F4C
2
TYSY_ECOLI
A:
[4-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
--
63
PsiBlast_CBE
57.91
59%
-26
- C6 -
-
1F4F
1
TYSY_ECOLI
B:
[4-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
---
89
PsiBlast_CBE
57.90
59%
-20
- C6 -
-
1BQ1
3
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
A
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
47
PsiBlast_CBE
57.85
59%
-22
- C6 -
-
2A9W
6
TYSY_ECOLI
D:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
66
PsiBlast_CBE
57.82
59%
-22
- C6 -
-
1F4C
2
TYSY_ECOLI
B:
[4-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
---
82
PsiBlast_CBE
57.80
59%
-27
- C6 -
-
1JG0
3
TYSY_ECOLI
A:
[4-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
A
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
A
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
-
65
PsiBlast_CBE
57.78
59%
-25
- C6 -
-
1F4E
5
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
49
PsiBlast_CBE
57.74
59%
-25
- C6 -
-
2A9W
2
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
60
PsiBlast_CBE
57.73
59%
-25
- C6 -
-
1JTU
3
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
48
PsiBlast_CBE
57.46
59%
-26
- C6 -
-
2A9W
2
TYSY_ECOLI
C:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
53
PsiBlast_CBE
57.42
59%
-17
- C6 -
-
1TLS
3
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
95
PsiBlast_CBE
57.40
59%
-24
- C6 -
-
1NCE
3
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
C
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
90
PsiBlast_CBE
57.37
59%
-16
- C6 -
-
1BQ1
3
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
A
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
68
PsiBlast_CBE
57.24
59%
-25
- C6 -
-
1F4B
2
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
102
PsiBlast_CBE
57.02
59%
-21
- C6 -
-
1F4D
3
TYSY_ECOLI
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
C
A
P
S
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
103
PsiBlast_CBE
56.64
59%
-24
- C6 -
-
1F4D
3
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
C
A
P
S
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
71
PsiBlast_CBE
56.59
59%
-24
- C6 -
-
2VF0
3
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
Q
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
62
PsiBlast_CBE
56.59
59%
-21
- C6 -
-
1JTQ
3
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
73
PsiBlast_CBE
56.46
59%
-21
- C6 -
-
1ZPR
3
TYSY_ECOLI
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
Q
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I