@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VL78: (2017-10-31 )
MNSQTKTNPETQVPYDVKHLHDLLEQQKIAYLRHPVPTAKERIDRLARLKRVLVKYQDQIAEAINLDYGNRAIMETKIGELLTCLEQIKYYSKNLTGWMKPSKRHISVLHQPAKGWVQYQPMGVIGIITPWNYPLLLSVGPLICALAAGNHAMIKISSASPNFGQVLENALSEAFPQELVAVVNGGGVISDTFSHLPFDKMIFTGSTSVGKTVMAAAAQNLVPVILELGGKSPALVHASVDMKDVAQRIAVGKLWNAGQTCVAPDHIFLPRDKTAEFIENFKLIVAGMYPHFRNNQDYTSIINDKQYNRIQGYLENARDQGARIIEINPQNEILDDVRKIAPTLVTGVTTAMDIMQNEIFGPVLPILEYDQIEEVIEFINSRPRPLAMYYFDYDQARADYISQHTHSGHFGINMVITHVAQDDLPFGGIGASGMGKYHGPEGFFGLSHERSVMSNPKLYSLKYILPPFNKPIHRFISKTLLR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.........250.......260.......270.......280.......-290.----------------.......300.......310......-------.320.......330.......340.......350.......360.......370.......380........390.......400.......410.......420.......430.......440.......450..----....--.460.........470.......480
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNSQTKTNPETQVP
Y
D
V
K
H
L
H
D
L
L
E
Q
Q
K
I
A
Y
LRHPVP
T
A
K
E
R
I
D
R
L
A
R
L
K
R
V
L
V
K
Y
Q
D
Q
I
A
E
A
INLDYGN
R
A
I
M
E
T
K
I
G
E
L
L
T
C
L
E
Q
I
K
Y
Y
S
KNLTGWMKPS
K
R
H
I
S
V
L
HQPAKG
W
V
Q
YQP
M
G
V
I
G
I
ITPWN
Y
P
L
L
L
SV
G
P
L
I
C
A
LAAG
N
H
A
M
I
K
I
SSASP
N
F
G
Q
V
L
E
N
A
L
S
E
A
F
P
Q
E
L
V
A
V
VNGGGVI
S
D
T
F
SHLPFD
K
M
I
FTGSTSV
G
K
T
V
M
A
A
A
A
Q
N
L
V
P
V
I
L
E
LGGKS
P
A
L
V
H
ASV--
D
M
K
D
V
A
Q
R
I
A
V
GKLWNAGQTCVAPD
H
I
FLPR
D
K
T
A
E
F
I
E
N
F
K
L
I
VAGMY-PH-F----------------RNNQ
D
Y
T
S
I
INDK
Q
Y
N
R
I
Q
G
Y
L
E
NAR-------DQG
A
R
I
I
E
INP
Q
N
E
I
L
D
D
V
R
K
I
A
P
T
L
V
T
G
V
T
T
A
M
D
I
M
Q
NEIFGPVLPIL
E
Y
D
Q
I
E
E
V
I
E
F
I
NS-RPR
P
L
A
M
Y
Y
FDY
D
Q
A
R
A
D
Y
I
S
QHTHSGHF
G
I
N
M
V
I
T
HVAQDDLPFGGIGASGMGKYHGPEGFFGLS
H
E
R
S
VMS----NP
K
L
--
Y
S
--
L
K
Y
ILPPF
N
K
P
I
H
R
F
I
S
K
T
LLR
35
PsiBlast_CBE
92.57
33%
-109
- C4 -
-
5UCD
1
MDLD_PSEPU
B:
[30-457]
-------------------
I
D
S
L
F
S
A
Q
K
A
Y
F
A
T
R
A
T
A
D
V
G
F
R
K
Q
S
L
E
R
L
K
E
A
V
I
N
N
K
E
A
L
Y
S
A
L
A
E
D
L
G
K
P
K
D
V
-
V
D
L
A
E
I
G
A
V
L
H
E
I
D
F
A
L
A
H
L
D
E
W
V
A
P
V
S
V
P
S
P
D
I
I
A
P
S
E
C
Y
V
V
Q
E
P
Y
G
V
T
Y
I
I
G
P
F
N
Y
P
V
N
L
T
L
T
P
L
I
G
A
I
I
G
G
N
T
C
I
I
K
P
S
E
T
T
P
E
T
S
A
V
I
E
K
I
I
A
E
A
F
A
P
E
Y
V
A
V
I
Q
G
G
R
D
E
N
S
H
L
L
S
L
P
F
D
F
I
F
F
T
G
S
P
N
V
G
K
V
V
M
Q
A
A
A
K
H
L
T
P
V
V
L
E
L
G
G
K
C
P
L
I
V
L
P
D
A
--
D
L
D
Q
T
V
N
Q
L
M
F
G
K
F
I
N
S
G
Q
T
-
I
A
P
D
Y
L
Y
V
H
Y
S
V
K
D
A
L
L
E
R
L
V
E
R
V
K
T
E
L
-
P
E
-
I
----------------
N
S
T
---
G
K
L
V
T
E
R
Q
V
Q
R
L
V
S
L
L
E
A
T
Q
-------
G
Q
----
V
L
V
G
S
Q
A
D
V
--
S
K
R
A
L
S
A
T
V
V
D
G
V
E
W
N
D
P
L
M
S
E
E
L
F
G
P
I
L
P
V
L
E
F
D
S
V
R
T
A
I
D
Q
V
N
K
H
H
P
K
P
L
A
V
Y
V
F
G
K
D
M
D
V
A
K
G
I
I
N
Q
I
Q
S
G
D
A
Q
V
N
G
V
M
L
H
A
F
S
P
Y
L
P
F
G
G
I
G
A
S
G
M
G
E
Y
H
G
H
F
S
Y
L
T
F
T
H
K
K
S
V
R
I
----
V
P
------------------------------
161
HHSearch
92.28
34%
-87
- C4 -
-
3SZA
-
AL3A1_HUMAN
B:
[18-467]
-----------------
S
K
I
S
E
A
V
K
R
A
R
A
A
F
S
S
G
R
T
R
P
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
H
K
-
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
L
D
K
D
L
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
E
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
--
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
-
G
E
D
A
----------------
K
K
S
R
D
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
E
------------
G
Q
K
V
-
A
Y
G
G
T
--
G
D
A
A
T
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
-
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
----
R
P
L
M
--
N
D
EG
L
K
V
R
Y
P
P
S
P
A
K
M
T
---------
8
PsiBlast_PDB
92.18
33%
-107
- C4 -
-
5UCD
1
MDLD_PSEPU
A:
[30-457]
-------------------
I
D
S
L
F
S
A
Q
K
A
Y
F
A
T
R
A
T
A
D
V
G
F
R
K
Q
S
L
E
R
L
K
E
A
V
I
N
N
K
E
A
L
Y
S
A
L
A
E
D
L
G
K
P
K
D
V
-
V
D
L
A
E
I
G
A
V
L
H
E
I
D
F
A
L
A
H
L
D
E
W
V
A
P
V
S
V
P
S
P
D
I
I
A
P
S
E
C
Y
V
V
Q
E
P
Y
G
V
T
Y
I
I
G
P
F
N
Y
P
V
N
L
T
L
T
P
L
I
G
A
I
I
G
G
N
T
C
I
I
K
P
S
E
T
T
P
E
T
S
A
V
I
E
K
I
I
A
E
A
F
A
P
E
Y
V
A
V
I
Q
G
G
R
D
E
N
S
H
L
L
S
L
P
F
D
F
I
F
F
T
G
S
P
N
V
G
K
V
V
M
Q
A
A
A
K
H
L
T
P
V
V
L
E
L
G
G
K
C
P
L
I
V
L
P
D
A
--
D
L
D
Q
T
V
N
Q
L
M
F
G
K
F
I
N
S
G
Q
T
-
I
A
P
D
Y
L
Y
V
H
Y
S
V
K
D
A
L
L
E
R
L
V
E
R
V
K
T
E
L
-
P
E
-
I
----------------
N
S
T
---
G
K
L
V
T
E
R
Q
V
Q
R
L
V
S
L
L
E
A
T
Q
-------
G
Q
----
V
L
V
G
S
Q
A
D
V
--
S
K
R
A
L
S
A
T
V
V
D
G
V
E
W
N
D
P
L
M
S
E
E
L
F
G
P
I
L
P
V
L
E
F
D
S
V
R
T
A
I
D
Q
V
N
K
H
H
P
K
P
L
A
V
Y
V
F
G
K
D
M
D
V
A
K
G
I
I
N
Q
I
Q
S
G
D
A
Q
V
N
G
V
M
L
H
A
F
S
P
Y
L
P
F
G
G
I
G
A
S
G
M
G
E
Y
H
G
H
F
S
Y
L
T
F
T
H
K
K
S
V
R
I
----
V
P
------------------------------
154
HHSearch
90.09
34%
-53
- C4 -
-
5MYP
1
?
B:
[11-486]
-------------
N
T
S
L
E
N
I
P
V
I
V
S
K
C
R
E
A
F
N
D
D
A
N
R
D
L
K
K
R
K
Q
V
L
R
S
L
L
N
L
V
E
E
N
T
D
E
F
C
K
A
I
H
R
D
R
R
R
-
H
R
D
E
T
V
V
M
E
I
L
P
L
R
N
E
V
W
H
L
I
E
H
M
D
E
Y
V
K
P
V
K
P
T
M
E
G
A
A
A
L
D
D
C
E
L
Q
Y
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
L
L
L
I
L
Q
P
L
L
G
A
L
A
A
G
N
T
A
V
I
K
P
S
E
L
A
P
A
T
A
E
L
L
T
K
L
L
P
K
Y
V
S
S
D
V
V
G
I
V
N
G
G
V
S
E
T
T
A
V
L
K
E
R
F
D
H
I
L
Y
T
G
S
A
R
V
A
E
I
V
M
A
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
V
V
V
D
D
T
C
AD
N
M
K
V
V
A
E
R
I
M
W
G
K
I
I
N
A
G
Q
T
C
I
A
P
D
Y
V
V
V
E
K
S
M
E
S
V
L
V
D
A
L
A
E
A
R
K
A
M
L
-
G
D
K
F
LKVLKGELLVKQKQQF
L
E
E
S
D
Y
P
R
I
V
N
A
S
H
F
Q
R
L
M
E
F
M
K
------------
G
G
K
V
-
A
V
G
G
E
--
A
D
E
A
T
L
T
I
A
P
T
I
L
T
N
I
D
P
T
H
P
V
M
Q
E
E
I
F
G
P
I
L
P
V
L
T
Y
E
N
E
K
D
I
L
K
I
I
N
S
-
R
E
K
P
L
A
L
Y
V
F
S
N
N
K
R
F
I
R
G
V
E
S
R
T
S
S
G
A
V
V
V
N
D
V
V
V
H
A
G
A
D
G
L
P
F
G
G
V
G
R
S
G
M
G
A
Y
H
G
R
Y
S
F
E
T
F
S
H
R
R
P
V
M
R
----
R
G
F
L
--
F
S
SI
D
T
V
R
F
P
P
Y
T
T
A
K
S
R
V
L
N
-----
28
PsiBlast_CBE
88.59
35%
-87
- C4 -
-
4H80
2
AL3A1_HUMAN
F:
[42-461]
-----------------------------------------
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
-
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
L
D
K
D
L
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
E
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
--
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
-
G
E
D
A
----------------
K
K
S
R
D
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
E
------------
G
Q
K
V
A
Y
G
G
T
G
D
A
A
---
T
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
-
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
----
R
P
L
M
ND
E
G
--
L
K
V
R
Y
P
P
---------------
30
PsiBlast_CBE
88.18
35%
-87
- C4 -
-
4H80
2
AL3A1_HUMAN
D:
[42-461]
-----------------------------------------
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
-
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
L
D
K
D
L
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
E
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
--
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
-
G
E
D
A
----------------
K
K
S
R
D
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
E
------------
G
Q
K
V
A
Y
G
G
T
G
D
A
A
---
T
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
-
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
----
R
P
L
M
ND
E
G
--
L
K
V
R
Y
P
P
---------------
33
PsiBlast_CBE
88.02
35%
-85
- C4 -
-
3SZB
1
AL3A1_HUMAN
B:
[42-461]
-----------------------------------------
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
-
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
L
D
K
D
L
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
E
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
--
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
-
G
E
D
A
----------------
K
K
S
R
D
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
E
------------
G
Q
K
V
A
Y
G
G
T
G
D
A
A
---
T
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
-
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
----
R
P
L
M
ND
E
G
--
L
K
V
R
Y
P
P
---------------
29
PsiBlast_CBE
87.80
35%
-87
- C4 -
-
4H80
2
AL3A1_HUMAN
E:
[42-461]
-----------------------------------------
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
-
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
L
D
K
D
L
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
E
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
--
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
-
G
E
D
A
----------------
K
K
S
R
D
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
E
------------
G
Q
K
V
A
Y
G
G
T
G
D
A
A
---
T
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
-
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
----
R
P
L
M
ND
E
G
--
L
K
V
R
Y
P
P
---------------
25
PsiBlast_CBE
87.72
35%
-84
- C4 -
-
4L1O
1
AL3A1_HUMAN
B:
[42-461]
-----------------------------------------
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
-
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
L
D
K
D
L
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
E
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
--
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
-
G
E
D
A
----------------
K
K
S
R
D
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
E
------------
G
Q
K
V
A
Y
G
G
T
G
D
A
A
---
T
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
-
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
----
R
P
L
M
ND
E
G
--
L
K
V
R
Y
P
P
---------------
3
PsiBlast_PDB
87.70
35%
-84
- C4 -
-
3SZA
-
AL3A1_HUMAN
A:
[42-461]
-----------------------------------------
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
-
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
L
D
K
D
L
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
E
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
--
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
-
G
E
D
A
----------------
K
K
S
R
D
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
E
------------
G
Q
K
V
A
Y
G
G
T
G
D
A
A
---
T
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
-
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
----
R
P
L
M
ND
E
G
--
L
K
V
R
Y
P
P
---------------
24
PsiBlast_CBE
87.68
35%
-86
- C4 -
-
4L2O
2
AL3A1_HUMAN
B:
[42-461]
-----------------------------------------
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
-
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
L
D
K
D
L
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
E
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
--
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
-
G
E
D
A
----------------
K
K
S
R
D
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
E
------------
G
Q
K
V
A
Y
G
G
T
G
D
A
A
---
T
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
-
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
----
R
P
L
M
ND
E
G
--
L
K
V
R
Y
P
P
---------------
6
PsiBlast_PDB
87.40
35%
-86
- C4 -
-
4L2O
2
AL3A1_HUMAN
A:
[42-461]
-----------------------------------------
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
-
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
L
D
K
D
L
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
E
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
--
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
-
G
E
D
A
----------------
K
K
S
R
D
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
E
------------
G
Q
K
V
A
Y
G
G
T
G
D
A
A
---
T
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
-
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
----
R
P
L
M
ND
E
G
--
L
K
V
R
Y
P
P
---------------
26
PsiBlast_CBE
87.18
35%
-87
- C4 -
-
4H80
2
AL3A1_HUMAN
H:
[42-461]
-----------------------------------------
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
-
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
L
D
K
D
L
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
E
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
--
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
-
G
E
D
A
----------------
K
K
S
R
D
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
E
------------
G
Q
K
V
A
Y
G
G
T
G
D
A
A
---
T
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
-
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
----
R
P
L
M
ND
E
G
--
L
K
V
R
Y
P
P
---------------
27
PsiBlast_CBE
87.17
35%
-86
- C4 -
-
4H80
2
AL3A1_HUMAN
G:
[42-461]
-----------------------------------------
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
-
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
L
D
K
D
L
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
E
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
--
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
-
G
E
D
A
----------------
K
K
S
R
D
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
E
------------
G
Q
K
V
A
Y
G
G
T
G
D
A
A
---
T
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
-
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
----
R
P
L
M
ND
E
G
--
L
K
V
R
Y
P
P
---------------
32
PsiBlast_CBE
87.10
35%
-88
- C4 -
-
4H80
2
AL3A1_HUMAN
B:
[42-461]
-----------------------------------------
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
-
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
L
D
K
D
L
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
E
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
--
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
-
G
E
D
A
----------------
K
K
S
R
D
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
E
------------
G
Q
K
V
A
Y
G
G
T
G
D
A
A
---
T
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
-
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
----
R
P
L
M
ND
E
G
--
L
K
V
R
Y
P
P
---------------
5
PsiBlast_PDB
87.09
35%
-86
- C4 -
-
4H80
2
AL3A1_HUMAN
A:
[42-461]
-----------------------------------------
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
-
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
L
D
K
D
L
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
E
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
--
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
-
G
E
D
A
----------------
K
K
S
R
D
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
E
------------
G
Q
K
V
A
Y
G
G
T
G
D
A
A
---
T
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
-
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
----
R
P
L
M
ND
E
G
--
L
K
V
R
Y
P
P
---------------
31
PsiBlast_CBE
87.00
35%
-86
- C4 -
-
4H80
2
AL3A1_HUMAN
C:
[42-461]
-----------------------------------------
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
-
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
L
D
K
D
L
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
E
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
--
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
-
G
E
D
A
----------------
K
K
S
R
D
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
E
------------
G
Q
K
V
A
Y
G
G
T
G
D
A
A
---
T
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
-
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
----
R
P
L
M
ND
E
G
--
L
K
V
R
Y
P
P
---------------
22
PsiBlast_CBE
86.98
35%
-85
- C4 -
-
4L2O
2
AL3A1_HUMAN
G:
[42-461]
-----------------------------------------
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
-
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
L
D
K
D
L
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
E
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
--
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
-
G
E
D
A
----------------
K
K
S
R
D
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
E
------------
G
Q
K
V
A
Y
G
G
T
G
D
A
A
---
T
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
-
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
----
R
P
L
M
ND
E
G
--
L
K
V
R
Y
P
P
---------------
23
PsiBlast_CBE
86.75
35%
-85
- C4 -
-
4L2O
2
AL3A1_HUMAN
E:
[42-461]
-----------------------------------------
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
-
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
L
D
K
D
L
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
E
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
--
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
-
G
E
D
A
----------------
K
K
S
R
D
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
E
------------
G
Q
K
V
A
Y
G
G
T
G
D
A
A
---
T
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
-
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
----
R
P
L
M
ND
E
G
--
L
K
V
R
Y
P
P
---------------
21
PsiBlast_CBE
86.72
33%
-54
- C4 -
-
1AD3
1
AL3A1_RAT
B:
[3-447]
-------------------
I
S
D
T
V
K
R
A
R
E
A
F
N
S
G
K
T
R
S
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
M
I
N
E
N
L
K
S
I
S
G
A
L
A
S
D
L
G
K
N
E
-
W
T
S
Y
Y
E
E
V
A
H
V
L
E
E
L
D
T
T
I
K
E
L
P
D
W
A
E
D
E
P
V
A
K
T
R
Q
T
Q
Q
D
D
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
A
W
N
Y
P
F
N
L
T
I
Q
P
M
V
G
A
V
A
A
G
N
A
V
I
L
K
P
S
E
V
S
G
H
M
A
D
L
L
A
T
L
I
P
Q
Y
M
D
Q
N
L
Y
L
V
V
K
G
G
V
P
E
T
T
E
L
L
K
E
R
F
D
H
I
M
Y
T
G
S
T
A
V
G
K
I
V
M
A
A
A
A
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
D
C
--
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
D
F
Y
G
E
D
-
A
----------------
K
Q
S
R
D
Y
G
R
I
I
N
D
R
H
F
Q
R
V
K
G
L
I
D
N
Q
K
VAHGGTW
D
Q
S
S
R
Y
I
---------------
A
P
T
I
L
V
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
M
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
-
R
E
K
P
L
A
L
Y
V
F
S
N
N
E
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
T
A
N
D
V
I
V
H
I
T
V
P
T
L
P
F
G
G
V
G
N
S
G
M
G
A
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
KSLL
N
E
E
A
--
H
K
--
A
R
Y
P
P
S
P
A
--------------