@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VL92: (2017-11-01 )
MKAVAYQKAGPITLPEALVDIELDTPVAKGHDLLIRVQAVSVNPVDTKIRKNVSAEQSGWKVLGWDAVGTVEAIGDKVTQFKIGDVVWYAGALNRQGSNSELQLVDERIVGHKPKTLEATEAAALPLTAITAWEMLFDRLQVPKTAPANTTILVIGGAGGVGSITIQLLKQLTNLTIIATASRPETKEWVEQLGADYVLDHRQSLAAQIKLLGLSAPLYVFSTTETDQHLSDIVELIAPQGHFGLIDDPDQLDIKPFKSKSVSVHWEFMFTRSMFQTEDMEKQSALLNEVSKLVDEGKIKTTVTQVLSPINAENLTRVHEQIESGSTKGKIVLHGF
Atome Classification :
(20 SA)
----......--.--..10-----------.........20.........30........40........50...----------------.-.-----.----------...60.---------------........70.......-.----80......-------------..90..--------------------------.-----------.....100.......110.......120.......130......--.--140..------------..---...-..--150.......160.......170.......180.......190.......200--------..------------------.-----------------------.------------------...-----------------------.--210..--......220.......230.....-.-.240....--...250---.--.--------.------------.----...260.-.......270.......---------280.......290.......300.--.--------.---....310.......320....-.-..-330....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----MKAVAY--Q--KAG------------PITLP
E
A
L
V
D
-
I
E
LDTPVAKG
H
D
L
L
I
R
V
Q
A
V
SVNP
V
D
T
K
I
R
-KNV----------------S-A-----E----------QSG
W
-
K
---------------
V
L
GWDAVG
T
V
E
A
IGDK
V
-
T
----
Q
F
KIG
D
V
V
-------------
W
Y
AGAL--------------------------N-----------RQGSNSE
L
Q
L
V
D
E
R
IVGHKPKTLEATEAAAL
P
L
T
A
I
T
A
W
E
M
L
F
D
--
R
--L--QV------------PK---TAP-A
N
--
T
T
I
L
V
I
GGAG
G
V
G
S
I
T
I
Q
L
L
K
Q
LTN
L
T
I
I
A
TASRP
E
T
K
E
W
V
E
Q
LG
A
D
Y
V
L
D
H
---------
R
Q
------------------
S
-----------------------
L
------------------
A
A
Q
-----------------------
I
--
K
L
-
L
G--LSA
P
L
Y
V
F
STTE
T
D
Q
H
L
S
D
I
V
E
L
I-A-PQGHFGLI--DDPDQL---D--I--------K------------P----FKSK
S
-
V
-
S
V
H
W
E
F
M
F
TRSMFQ
T
E
D
---------
M
E
K
Q
S
A
L
L
N
E
V
S
K
L
V
DEGK
I
K
T
T
V
--
T
--------
Q
---
V
LSPI
N
A
E
N
L
T
R
V
H
E
Q
I
E
SGS-T-K
G
-
K
I
V
L
HGF
1
PsiBlast_PDB
91.36
58%
-37
- C2 -
-
4DVJ
-
?
A:
[24-359]
-----
K
A
V
G
Y
--
N
--
K
P
A
------------
P
I
T
D
D
A
S
L
L
D
-
I
E
L
P
K
P
A
P
A
G
H
D
I
L
V
E
V
K
A
V
S
V
N
P
V
D
Y
K
V
R
-
R
S
T
----------------
P
-
P
-----------------
T
D
W
-
K
---------------
V
I
G
Y
D
A
A
G
I
V
S
A
V
G
P
D
V
-
T
----
L
F
R
P
G
D
E
V
-------------
F
Y
A
G
S
I
--------------------------
I
-----------
R
P
G
T
N
A
E
F
H
L
V
D
E
R
I
V
G
R
K
P
K
T
L
D
W
A
E
A
A
A
L
P
L
T
S
I
T
A
W
E
A
F
F
D
--
R
--
L
--
D
V
------------
N
K
---
P
V
P
G
A
A
--
P
A
I
L
I
V
G
G
A
G
G
V
G
S
I
A
V
Q
I
A
R
Q
R
T
D
L
T
V
I
A
T
A
S
R
P
E
T
Q
E
W
V
K
S
L
G
A
H
H
V
I
D
H
---------
S
K
------------------
P
-----------------------
L
------------------
A
A
E
-----------------------
V
--
A
A
-
L
G
--
L
G
A
P
A
F
V
F
S
T
T
H
T
D
K
H
A
A
E
I
A
D
L
I
-
A
-
P
Q
G
R
F
C
L
I
--
D
D
P
S
A
F
---
D
--
I
--------
M
------------
L
----
F
K
R
K
A
-
V
-
S
I
H
H
E
L
M
F
T
R
P
M
F
G
T
P
D
---------
M
S
E
Q
G
R
L
L
N
D
V
S
R
L
V
D
E
G
R
L
R
T
T
L
--
T
--------
N
---
R
L
S
P
I
N
A
A
N
L
K
Q
A
H
A
L
V
E
S
G
T
-
A
-
R
G
-
K
V
V
I
E
G
F
95
HHSearch
88.94
57%
-34
- C2 -
-
4DVJ
-
?
B:
[23-358]
----
M
K
A
V
G
Y
--
N
--
K
P
A
------------
P
I
T
D
D
A
S
L
L
D
-
I
E
L
P
K
P
A
P
A
G
H
D
I
L
V
E
V
K
A
V
S
V
N
P
V
D
Y
K
V
R
-
R
S
T
----------------
P
-
P
-----
D
-----------
T
D
W
-
K
---------------
V
I
G
Y
D
A
A
G
I
V
S
A
V
G
P
D
V
-
T
----
L
F
R
P
G
D
E
V
-------------
F
Y
A
G
S
I
--------------------------
I
-----------
R
P
G
T
N
A
E
F
H
L
V
D
E
R
I
V
G
R
K
P
K
T
L
D
W
A
E
A
A
A
L
P
L
T
S
I
T
A
W
E
A
F
F
D
--
R
--
L
--
D
V
------------
N
K
PV-
P
G
A
--
A
--
P
A
I
L
I
V
G
G
A
G
G
V
G
S
I
A
V
Q
I
A
R
Q
R
T
D
L
T
V
I
A
T
A
S
R
P
E
T
Q
E
W
V
K
S
L
G
A
H
H
V
I
D
H
---------
S
K
------------------
P
-----------------------
L
------------------
A
A
E
-----------------------
V
--
A
A
-
L
G
--
L
G
A
P
A
F
V
F
S
T
T
H
T
D
K
H
A
A
E
I
A
D
L
I
-
A
-
P
Q
G
R
F
C
L
I
--
D
D
P
S
A
F
---
D
--
I
--------
M
------------
L
----
F
K
R
K
A
-
V
-
S
I
H
H
E
L
M
F
T
R
P
M
F
G
T
P
D
---------
M
S
E
Q
G
R
L
L
N
D
V
S
R
L
V
D
E
G
R
L
R
T
T
L
--
T
--------
N
R
L
S
P
I
-
N
A
--
A
N
L
K
Q
A
H
A
L
V
E
S
G
T
-
A
-
R
G
-
K
V
V
I
E
G
-
85
HHSearch
77.54
41%
-32
- C2 -
-
3FBG
-
?
A:
[3-337]
----
L
K
A
I
G
F
--
E
--
Q
P
F
------------
K
L
S
D
G
N
L
F
K
T
-
F
N
L
D
I
P
E
P
K
V
H
E
I
L
V
K
I
Q
S
I
S
V
N
P
V
D
T
K
Q
R
-
L
M
D
----------------
V
-
S
-----------------
K
A
P
-
R
---------------
V
L
G
F
D
A
I
G
V
V
E
S
V
G
N
E
V
-
T
----
M
F
N
Q
G
D
I
V
-------------
Y
Y
S
G
S
P
--------------------------
D
-----------
Q
N
G
S
N
A
E
Y
Q
L
I
N
E
R
L
V
A
K
A
P
K
N
I
S
A
E
Q
A
V
S
L
P
L
T
G
I
T
A
Y
E
T
L
F
D
--
V
--
F
--
G
I
------------
S
R
NRN
E
N
E
--
G
--
K
T
L
L
I
I
N
G
A
G
G
V
G
S
I
A
T
Q
I
A
K
A
Y
G
-
L
R
V
I
T
T
A
S
R
N
E
T
I
E
W
T
K
K
M
G
A
D
I
V
L
N
H
---------
K
E
------------------
S
-----------------------
L
------------------
L
N
Q
-----------------------
F
--
K
T
-
Q
G
--
I
E
L
V
D
Y
V
F
C
T
F
N
T
D
M
Y
Y
D
D
M
I
Q
L
V
-
K
-
P
R
G
H
I
A
T
I
--
V
A
F
E
N
D
Q--
D
--
L
--------
N
------------
A
----
L
K
P
K
S
-
L
-
S
F
S
H
E
F
M
F
A
R
P
L
N
Q
T
D
D
---------
M
I
K
H
H
E
Y
L
E
D
I
T
N
K
V
E
Q
N
I
Y
Q
P
T
T
--
T
K
V
I
-----
E
---
G
L
-
T
T
--
E
N
I
Y
Q
A
H
Q
I
L
E
S
N
T
-
M
-
I
G
-
K
L
V
I
N
L
-
86
HHSearch
75.63
41%
-38
- C2 -
-
3FBG
-
?
B:
[3-337]
----
L
K
A
I
G
F
--
E
--
Q
P
F
------------
K
L
S
D
G
N
L
F
K
T
-
F
N
L
D
I
P
E
P
K
V
H
E
I
L
V
K
I
Q
S
I
S
V
N
P
V
D
T
K
Q
R
-
L
M
D
----------------
V
-
S
-------------------
P
-
R
---------------
V
L
G
F
D
A
I
G
V
V
E
S
V
G
N
E
V
-
T
----
M
F
N
Q
G
D
I
V
-------------
Y
Y
S
G
S
P
--------------------------
D
-----------
Q
N
G
S
N
A
E
Y
Q
L
I
N
E
R
L
V
A
K
A
P
K
N
I
S
A
E
Q
A
V
S
L
P
L
T
G
I
T
A
Y
E
T
L
F
D
--
V
--
F
--
G
I
------------
S
R
NRN
E
N
E
--
G
--
K
T
L
L
I
I
N
G
A
G
G
V
G
S
I
A
T
Q
I
A
K
A
Y
G
-
L
R
V
I
T
T
A
S
R
N
E
T
I
E
W
T
K
K
M
G
A
D
I
V
L
N
H
---------
K
E
------------------
S
-----------------------
L
------------------
L
N
Q
-----------------------
F
--
K
T
-
Q
G
--
I
E
L
V
D
Y
V
F
C
T
F
N
T
D
M
Y
Y
D
D
M
I
Q
L
V
-
K
-
P
R
G
H
I
A
T
I
--
V
A
F
E
N
D
Q
--
D
--
L
--------
N
------------
A
----
L
K
P
K
S
-
L
-
S
F
S
H
E
F
M
F
A
R
P
L
N
Q
T
D
D
---------
M
I
K
H
H
E
Y
L
E
D
I
T
N
K
V
E
Q
N
I
Y
Q
P
T
T
--
T
K
V
I
-----
E
---
G
L
-
T
T
--
E
N
I
Y
Q
A
H
Q
I
L
E
S
N
--
M
-
I
G
-
K
L
V
I
N
L
-
2
PsiBlast_PDB
73.38
40%
-3
- C2 -
-
3FBG
-
?
A:
[3-336]
----
L
K
A
I
G
F
--
E
--
Q
P
F
------------
K
L
S
D
G
N
L
F
K
T
-
F
N
L
D
I
P
E
P
K
V
H
E
I
L
V
K
I
Q
S
I
S
V
N
P
V
D
T
K
Q
R
L
M
D
V
----------------
S
-------------------
K
A
P
-
R
---------------
V
L
G
F
D
A
I
G
V
V
E
S
V
G
N
E
V
-
T
----
M
F
N
Q
G
D
I
V
-------------
Y
Y
S
G
S
P
--------------------------
D
-----------
Q
N
G
S
N
A
E
Y
Q
L
I
N
E
R
L
V
A
K
A
P
K
N
I
S
A
E
Q
A
V
S
L
P
L
T
G
I
T
A
Y
E
T
L
F
D
--
V
--
F
--
G
I
------------
S
R
---
N
R
N
-
E
N
EG
K
T
L
L
I
I
N
G
A
G
G
V
G
S
I
A
T
Q
I
A
K
A
Y
-
G
L
R
V
I
T
T
A
S
R
N
E
T
I
E
W
T
K
K
M
G
A
D
I
V
L
N
H
---------
K
E
------------------
S
-----------------------
L
------------------
L
N
Q
-----------------------
F
--
K
T
-
Q
G
--
I
E
L
V
D
Y
V
F
C
T
F
N
T
D
M
Y
Y
D
D
M
I
Q
L
V
-
K
-
P
R
G
H
I
A
T
I
VA
F
E
N
D
Q
----
D
--
L
--------
N
------------
A
----
L
K
P
K
S
-
L
-
S
F
S
H
E
F
M
F
A
R
P
L
N
Q
T
D
D
---------
M
I
K
H
H
E
Y
L
E
D
I
T
N
K
V
E
Q
N
I
Y
Q
P
T
T
--
T
--------
K
---
V
I
E
G
L
T
T
E
N
I
Y
Q
A
H
Q
I
L
E
S
N
T
-
M
-
I
G
-
K
L
V
I
N
--
90
HHSearch
62.72
26%
-21
- C2 -
-
4RVU
1
?
C:
[5-332]
----
M
H
A
I
E
V
--
T
--
E
T
G
------------
G
P
---
G
V
L
R
H
-
V
D
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
-
S
G
Q
----------------
Y
-
P
-----
R
-----------
E
L
P
-
F
---------------
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
V
-
T
AADT
A
I
S
V
G
D
R
V
-------------
V
S
A
S
----------------------------------------
A
N
G
A
Y
A
E
F
C
T
A
P
A
S
L
T
A
K
V
P
D
D
V
T
S
E
V
A
A
S
A
L
L
K
G
L
T
A
H
Y
L
L
K
S
--
V
--
Y
--
P
V
------------
K
------
R
--
G
--
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
-
V
R
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
---------
P
E
D
A
W
---------------
Q
-----------------------
F
------------------
A
G
R
-----------------------
V
--
R
E
-
L
T
G
-
G
T
G
V
Q
A
V
Y
D
G
V
G
A
-
T
T
F
D
A
S
L
A
S
L
-
A
-
V
R
G
T
L
A
L
F
--
G
A
A
S
G
P
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P
--
V
--------
D
P
Q
----------
R
----
L
N
A
A
G
S
V
-
Y
L
T
R
P
S
L
F
---
H
F
T
-
R
T
---------
G
E
E
F
S
W
R
A
A
E
L
F
D
A
I
N
S
E
A
I
T
V
A
V
--
G
--------
G
---
R
Y
-
P
L
--
A
D
A
L
R
A
H
Q
D
L
E
A
R
K
-
T
-
V
G
-
S
V
V
L
L
P
-
89
HHSearch
62.10
26%
-22
- C2 -
-
4RVS
-
?
A:
[2-328]
----
M
H
A
I
E
V
--
T
--
E
T
G
------------
G
P
---
G
V
L
R
H
-
V
D
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
-
S
G
Q
----------------
Y
-
P
-----
R
-----------
E
L
P
-
F
---------------
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
V
-
T
AADT
A
I
S
V
G
D
R
V
-------------
V
S
A
S
----------------------------------------
A
N
G
A
Y
A
E
F
C
T
A
P
A
S
L
T
A
K
V
P
D
D
V
T
S
E
V
A
A
S
A
L
L
K
G
L
T
A
H
Y
L
L
K
S
--
V
--
Y
--
P
V
------------
K
------
R
--
G
--
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
-
V
R
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
---------
P
E
D
A
W
---------------
Q
-----------------------
F
------------------
A
G
R
-----------------------
V
--
R
E
-
L
T
G-
G
T
G
V
Q
A
V
Y
D
G
V
G
A
-
T
T
F
D
A
S
L
A
S
L
-
A
-
V
R
G
T
L
A
L
F
--
G
A
A
S
G
P
---
V
P
P
V
--------
D
------------
P
Q
R
--
L
N
A
A
G
-
S
V
Y
L
T
R
P
S
L
F
---
H
F
T
-
R
T
---------
G
E
E
F
S
W
R
A
A
E
L
F
D
A
I
G
N
E
A
I
T
V
A
V
--
G
--------
G
---
R
Y
-
P
L
--
A
D
A
L
R
A
H
Q
D
L
E
A
R
K
-
T
-
V
G
-
S
V
V
L
L
--
83
HHSearch
59.86
26%
-17
- C2 -
-
4DUP
-
?
A:
[7-331]
----
M
R
F
V
D
L
--
K
--
S
F
G
------------
G
P
---
D
V
M
V
I
-
G
K
R
P
L
P
V
A
G
E
G
E
V
L
V
R
A
E
A
I
G
V
N
R
P
D
I
A
Q
R
-
Q
G
S
----------------
Y
-
P
-----
P
P---------
K
D
A
S
-
P
---------------
I
L
G
L
E
L
S
G
E
I
V
G
V
G
P
G
V
-
S
----
G
Y
A
V
G
D
K
V
-------------
C
G
L
A
N
----------------------------------------
G
G
A
Y
A
E
Y
C
L
L
P
A
G
Q
I
L
P
F
P
K
G
Y
D
A
V
K
A
A
A
L
P
E
T
F
F
T
V
W
A
N
L
F
Q
--
M
--
A
--
G
L
------------
T
------
E
--
G
--
E
S
V
L
I
H
G
G
T
S
G
I
G
T
T
A
I
Q
L
A
R
A
F
G
-
A
E
V
Y
A
T
A
G
S
T
G
K
C
E
A
C
E
R
L
G
A
K
R
G
I
N
Y
---------
R
S
E-----------------
D
-----------------------
F
------------------
A
A
V
-----------------------
I
--
K
A
-
E
T
--
G
Q
G
V
D
I
I
L
D
M
I
G
A
-
A
Y
F
E
R
N
I
A
S
L
-
A
-
K
D
G
C
L
S
I
I
--
A
F
L
G
G
A
VAE
K
--
V
NL------
S
------------
P
----
I
M
V
K
R
-
L
-
T
V
T
G
S
T
M
R
P
R
-
T
A
E
-
E
K
---------
R
A
I
R
D
D
L
L
S
E
V
W
P
L
L
E
A
G
T
V
A
P
V
I
--
H
--------
K
---
V
F
-
A
F
--
E
D
V
A
D
A
H
R
L
L
E
E
G
S
-
H
-
V
G
-
K
V
M
L
T
V
-
92
HHSearch
58.68
28%
7
- C2 -
-
1YB5
5
QOR_HUMAN
A:
[30-351]
----
M
R
A
V
R
V
--
F
--
E
F
G
------------
G
P
---
E
V
L
K
L
R
S
D
I
A
V
P
I
P
K
D
H
Q
V
L
I
K
V
H
A
C
G
V
N
P
V
E
T
Y
I
R
-
S
G
T
----------------
Y
-
S
R----
K
----------
P
L
L
P
-
Y
---------------
T
P
G
S
D
V
A
G
V
I
E
A
V
G
D
N
A
-
S
----
A
F
K
K
G
D
R
V
-------------
F
T
S
S
T
---------------------------------------
I
S
G
G
Y
A
E
Y
A
L
A
A
D
H
T
V
Y
K
L
P
E
K
L
D
F
K
Q
G
A
A
I
G
I
P
Y
F
T
A
Y
R
A
L
I
H
--
S
--
A
--
C
V
------------
K
------
A
--
G
--
E
S
V
L
V
H
G
A
S
G
G
V
G
L
A
A
C
Q
I
A
R
A
Y
G
-
L
K
I
L
G
T
A
G
T
E
E
G
Q
K
I
V
L
Q
N
G
A
H
E
V
F
N
H
---------
R
E
V-----------------
N
-----------------------
Y
------------------
I
D
K
-----------------------
I
--
K
K
-
Y
V
G-
E
K
G
I
D
I
I
I
E
M
L
A
N
-
V
N
L
S
K
D
L
S
L
L
-
S
-
H
G
G
R
V
I
V
V
--
G
S
R
G
T
I
---
E
--
I
N
P
------
R
------------
D
----
T
M
A
K
E
-
S
-
S
I
I
G
V
T
L
F
-----
S
-
S
T
---------
K
E
E
F
Q
Q
Y
A
A
A
L
Q
A
G
M
E
I
G
W
L
K
P
V
I
--
G
--------
S
---
Q
Y
-
P
L
--
E
K
V
A
E
A
H
E
N
I
I
H
G
S
G
A
-
T
G
-
K
M
I
L
L
L
-
82
HHSearch
58.09
24%
-7
- C2 -
-
4Y1B
1
?
A:
[41-422]
----
M
Y
A
S
L
I
R
Q
E
--
R
Y
G
------------
R
P
--
V
D
A
F
R
T
-
E
V
V
D
V
P
P
V
G
P
G
Q
V
L
V
K
V
M
A
A
G
V
N
Y
N
N
V
W
A
A
-
L
G
E
----------------
P
-
L
-----
D
V
I
A
A
R
Q
K
Q
GA
T
E
D
F
-
H
---------------
I
G
G
S
D
L
S
G
I
V
W
A
V
G
D
G
V
------
R
L
K
P
G
A
E
V
-------------
V
V
L
A
C
R
W
D
ESA
Q
D
I
R
L
GADPVTSST
Q
R
V
W
GYE
E
-----------
N
Y
G
S
F
A
Q
F
A
V
V
D
E
Y
M
C
H
P
K
P
Q
R
L
S
W
A
A
A
S
C
Y
M
A
T
A
A
T
A
Y
R
Q
L
F
G
--
W
EP
H
--
T
V
------------
R
------
P
--
G
--
D
P
V
L
I
W
G
G
A
G
G
L
G
S
I
A
I
Q
L
V
R
H
V
G
-
G
I
P
V
A
V
V
S
S
E
E
R
G
E
F
C
M
R
L
G
A
K
G
W
I
D
R
---------
R
E
F-----------------
D
-----------------------
H
------------------
W
G
R
LPDTTD
E
E
A
M
K
Q
W
L
D
G
A
R
A
F
G
R
R
F
--
W
E
V
L
G
E-
R
R
A
P
R
I
V
L
E
H
S
G
A
-
D
T
I
P
T
S
I
Y
M
A
-
D
-
N
A
G
M
V
V
I
C
--
G
G
T
T
G
Y
---
N
GD
V
D
L
------
R
------------
F
----
L
W
M
R
Q
-
K
-
R
L
Q
G
------------
S
---------
H
A
A
S
A
R
E
A
R
E
I
T
R
L
I
D
Q
G
A
I
D
P
C
L
--
S
--------
R
---
T
F
-
G
F
--
E
E
I
G
L
A
H
Q
L
I
H
D
N
Q
-
H
P
S
G
-
N
M
A
V
L
V
-
84
HHSearch
56.87
26%
-31
- C2 -
-
4DUP
-
?
B:
[7-331]
----
M
R
F
V
D
L
--
K
--
S
F
G
------------
G
P
---
D
V
M
V
I
-
G
K
R
P
L
P
V
A
G
E
G
E
V
L
V
R
A
E
A
I
G
V
N
R
P
D
I
A
Q
R
-
Q
G
S
----------------
Y
-
P
-----
P
P---------
K
D
A
S
-
P
---------------
I
L
G
L
E
L
S
G
E
I
V
G
V
G
P
---------
Y
A
V
G
D
K
V
-------------
C
G
L
A
N
----------------------------------------
G
G
A
Y
A
E
Y
C
L
L
P
A
G
Q
I
L
P
F
P
K
G
Y
D
A
V
K
A
A
A
L
P
E
T
F
F
T
V
W
A
N
L
F
Q
--
M
--
A
--
G
L
------------
T
------
E
--
G
--
E
S
V
L
I
H
G
G
T
S
G
I
G
T
T
A
I
Q
L
A
R
A
F
G
-
A
E
V
Y
A
T
A
-------
A
C
E
R
L
G
A
K
R
G
I
N
Y
---------
R
S
E-----------------
D
-----------------------
F
------------------
A
A
V
-----------------------
I
--
K
A
-
E
T
--
G
Q
G
V
D
I
I
L
D
M
I
G
A
-
A
Y
F
E
R
N
I
A
S
L
-
A
-
K
D
G
C
L
S
I
I
--
A
F
L
G
G
A
VAE
K
--
V
NL------
S
------------
P
----
I
M
V
K
R
-
L
-
T
V
T
G
S
T
M
R
P
R
-
T
A
E
-
E
K
---------
R
A
I
R
D
D
L
L
S
E
V
W
P
L
L
E
A
G
T
V
A
P
V
I
--
H
--------
K
---
V
F
-
A
F
--
E
D
V
A
D
A
H
R
L
L
E
---------
K
V
M
L
T
V
-
88
HHSearch
54.92
23%
-11
- C2 -
-
4A0S
4
?
C:
[49-413]
------------------------------------
S
L
R
L
-
G
E
V
P
M
P
E
L
A
P
D
E
V
L
V
A
V
M
A
S
S
I
N
Y
N
T
V
W
S
A
-
M
F
E
PIPTFHFLKQNARQGG
W
-
A
TR---
H
----------
D
Q
P
Y
-
H
---------------
V
L
G
S
D
C
S
G
V
V
V
R
T
G
I
G
V
-
R
----
R
W
K
P
G
D
H
V
-------------
I
V
H
P
A
H
VDEQEPATHGDGMLGTEQRAWGFE--
T
-----------
N
F
G
G
L
A
E
Y
G
V
V
R
A
S
Q
L
L
P
K
P
A
H
L
T
W
E
E
A
A
V
S
P
L
C
A
G
T
A
Y
R
M
L
V
S
DR
G
--
A
--
Q
M
------------
K
------
Q
--
G
--
D
I
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
I
Q
F
V
K
N
G
G
-
G
I
P
V
A
V
V
S
S
A
Q
K
E
A
A
V
R
A
L
G
C
D
L
V
I
N
R
---------
A
E
L-----------------
G
-----------------------
I
TDDIADDPRRVVETGRKL
A
K
L
-----------------------
V
--
V
E
-
K
A
--
G
R
E
P
D
I
V
F
E
H
T
G
R
-
V
T
F
G
L
S
V
I
V
A
-
R
-
R
G
G
T
V
V
T
C
--
G
S
S
S
G
Y
---
L
HT
F
DN------
R
------------
Y
----
L
W
M
K
L
-
K
-
K
I
V
G
S
---------------------
H
G
A
N
H
E
E
Q
Q
A
T
N
R
L
F
E
S
G
A
V
V
P
A
M
--
S
--------
A
---
V
Y
-
P
L
--
A
E
A
A
E
A
C
R
V
V
Q
T
S
R
-
Q
-
V
G
-
K
V
A
V
L
C
-
78
HHSearch
54.46
21%
-4
- C2 -
-
4GI2
1
?
A:
[35-410]
----
M
Y
A
W
A
I
--
R
RE
R
H
G
------------
P
P
--
E
Q
S
H
Q
L
-
E
V
L
P
V
W
E
I
G
D
D
E
V
L
V
Y
V
M
A
A
G
V
N
Y
N
G
V
W
A
G
-
L
G
E
----------------
P
-
I
-----
S
PFDVH-----
K
G
E
Y
-
H
---------------
I
A
G
S
D
A
S
G
I
V
W
K
V
G
A
K
V
-
K
----
R
W
K
V
G
D
E
V
-------------
I
V
H
C
N
Q
DDGDDEECNGGDPMFSPT
Q
R
I
W
GYE-
T
-----------
G
D
G
S
F
A
Q
F
C
R
V
Q
S
R
Q
L
M
A
R
P
K
H
L
T
W
E
E
A
A
C
Y
T
L
T
L
A
T
A
Y
R
M
L
F
G
--
H
--
A
PH
T
V
------------
R
------
P
--
G
--
Q
N
V
L
I
W
G
A
S
G
G
L
G
V
F
G
V
Q
L
C
A
A
S
G
-
A
N
A
I
A
V
I
S
D
E
S
K
R
D
Y
V
M
S
L
G
A
K
G
V
I
N
R
---------
K
D
------------------
F
DCWGQLPTVNS
P
E
Y
N
T
W
L
K
E
A
R
K
F
------------------
G
K
A
-----------------------
I
--
W
D
-
I
T
GK
G
N
D
V
D
I
V
F
E
H
P
G
E
-
A
T
F
P
V
S
T
L
V
A
-
K
-
R
G
G
M
I
V
F
C
--
A
G
T
T
G
F
---
N
--
I
T
F
D
A
----
R
------------
Y
----
V
W
M
R
Q
-
K
-
R
I
Q
G
S
---------------------
H
F
A
H
L
K
Q
A
S
A
A
N
Q
F
V
M
D
R
R
V
D
P
C
M
--
S
--------
E
---
V
F
-
P
W
--
D
K
I
P
A
A
H
T
K
M
W
K
N
Q
-
H
P
P
G
-
N
M
A
V
L
V
-
6
PsiBlast_PDB
54.06
27%
-12
* C1 *
-
2EIH
-
?
A:
[1-341]
----
M
R
A
V
V
M
--
R
--
A
R
G
------------
G
---
P
E
V
L
E
V
-
A
D
L
P
V
P
E
P
G
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
-
K
G
V
----------------
A
-
S
-----
P
----------
K
L
P
L
P
H
---------------
V
L
G
A
D
G
S
G
V
V
D
A
V
G
P
G
V
-
E
----
G
F
A
P
G
D
E
V
V
I
NPGLSCGRC
E
R
C
L
A
G
E
D
--------------------------
N
LCPRYQILGEH
R
H
G
T
Y
A
E
Y
V
V
L
P
E
A
N
L
A
P
K
P
K
N
L
S
F
E
E
A
A
A
I
P
L
T
F
L
T
A
W
Q
M
V
V
D
--
K
--
L
--
G
V
------------------
R
P
-
G
D
---
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
K
-
L
F
G
A
R
V
I
A
T
A
G
S
E
D
K
L
R
R
A
K
A
L
G
A
D
E
T
V
N
Y
THPD
W
P
K
E
V
R
R
------------------
L
-----------------------
T
------------------
G
G
K
-----------------------
G
AD
K
V
-
V
D
--
H
T
G
A
L
Y
F
E
G
V
I
K
A
T
A
N
G
G
R
I
A
I
A
G
-
A
-
S
S
G
Y
E
G
T
L
------------------------------------
P
----
F
A
H
-----------
V
F
Y
R
Q
L
S
I
L
G
S
---------
T
M
A
S
K
S
R
L
F
P
I
L
R
F
V
E
E
G
K
L
K
P
V
V
--
G
--------
Q
---
V
L
-
P
L
E
A
A
--
A
E
G
H
R
L
L
E
E
R
R
-
V
-
F
G
-
K
V
V
L
Q
--
81
HHSearch
53.94
22%
-11
- C2 -
-
2C0C
1
PTGR3_HUMAN
B:
[24-360]
----
M
Q
K
L
V
V
--
T
--
R
L
S
------------
P
N
-
F
R
E
A
V
T
L
S
R
D
C
P
V
P
L
P
G
D
G
D
L
L
V
R
N
R
F
V
G
V
N
A
S
D
I
N
Y
S
-
A
G
R
----------------
Y
D
P
-----
S
----------
V
K
P
P
-
F
---------------
D
I
G
F
E
G
I
G
E
V
V
A
L
G
L
S
A
S
A
----
R
Y
T
V
G
Q
A
V
-------------
A
Y
M
A
-----------------------------------------
P
G
S
F
A
E
Y
T
V
V
P
A
S
I
A
T
P
V
P
S
V
K
--
P
E
Y
L
T
L
L
V
S
G
T
T
A
Y
I
S
L
K
E
--
L
--
G
--
G
L
------------
S
------
E
--
G
--
K
K
V
L
V
T
A
A
A
G
G
T
G
Q
F
A
M
Q
L
S
K
K
A
K
-
C
H
V
I
G
T
C
S
S
D
E
K
S
A
F
L
K
S
L
G
C
D
R
P
I
N
Y
---------
K
T
E-----------------
P
-----------------------
V
------------------
G
T
V
-----------------------
L
--
K
Q
-
E
Y
--
P
E
G
V
D
V
V
Y
E
S
V
G
G
-
A
M
F
D
L
A
V
D
A
L
-
A
-
T
K
G
R
L
I
V
I
--
G
F
I
S
G
Y
---
Q
--
T
P-------
T
GLSPVKAGT
L
P
A
K
----
L
L
K
K
S
-
A
-
S
V
Q
G
F
F
L
N
-------
H
Y
---------
L
S
K
Y
Q
A
A
M
S
H
L
L
E
M
C
V
S
G
D
L
V
C
E
V
--
D
LGDLSPEG
R
---
F
T
-
G
L
--
E
S
I
F
R
A
V
N
Y
M
Y
M
G
K
-
N
-
T
G
-
K
I
V
V
E
L
-
87
HHSearch
53.86
23%
-10
- C2 -
-
4A0S
4
?
B:
[49-413]
------------------------------------
S
L
R
L
-
G
E
V
P
M
P
E
L
A
P
D
E
V
L
V
A
V
M
A
S
S
I
N
Y
N
T
V
W
S
A
-
M
F
E
PIPTFHFLKQNARQGG
W
-
A
TR---
H
----------
D
Q
P
Y
-
H
---------------
V
L
G
S
D
C
S
G
V
V
V
R
T
G
I
G
V
-
R
----
R
W
K
P
G
D
H
V
-------------
I
V
H
P
A
H
VDEQEPATHGDGMLGTEQRAWGFE--
T
-----------
N
F
G
G
L
A
E
Y
G
V
V
R
A
S
Q
L
L
P
K
P
A
H
L
T
W
E
E
A
A
V
S
P
L
C
A
G
T
A
Y
R
M
L
V
S
DR
G
--
A
--
Q
M
------------
K
------
Q
--
G
--
D
I
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
I
Q
F
V
K
N
G
G
-
G
I
P
V
A
V
V
S
S
A
Q
K
E
A
A
V
R
A
L
G
C
D
L
V
I
N
R
---------
A
E
L-----------------
G
-----------------------
I
TDDIADDPRRVVETGRKL
A
K
L
-----------------------
V
--
V
E
-
K
A
--
G
R
E
P
D
I
V
F
E
H
T
G
R
-
V
T
F
G
L
S
V
I
V
A
-
R
-
R
G
G
T
V
V
T
C
--
G
S
S
S
G
Y
---
L
HT
F
DN------
R
------------
Y
----
L
W
M
K
L
-
K
-
K
I
V
G
S
---------------------
H
G
A
N
H
E
E
Q
Q
A
T
N
R
L
F
E
S
G
A
V
V
P
A
M
--
S
--------
A
---
V
Y
-
P
L
--
A
E
A
A
E
A
C
R
V
V
Q
T
S
R
-
Q
-
V
G
-
K
V
A
V
L
C
-
94
HHSearch
52.37
23%
-10
- C2 -
-
3GQV
3
LOVC_ASPTE
A:
[12-360]
----
Q
T
A
L
T
V
--
N
--
D
H
D
------------
E
V
-----
T
V
W
-
N
A
A
P
C
P
M
L
P
R
D
Q
V
Y
V
R
V
E
A
V
A
I
N
P
S
D
T
S
------------------------
A
-----------------
T
P
W
-
A
---------------
F
L
G
T
D
Y
A
G
T
V
V
A
V
G
S
D
V
-
T
----
H
I
Q
V
G
D
R
V
-------------
Y
G
A
Q
N
E
MCPRT---------------------
P
-----------
D
Q
G
A
F
S
Q
Y
T
V
T
R
G
R
V
W
A
K
I
P
K
G
L
S
F
E
Q
A
A
A
L
P
A
G
I
S
T
A
G
L
A
M
K
L
--
L
--
G
--
L
P
LPSPSADQPPTH
S
------
K
--
P
--
V
Y
V
L
V
Y
G
G
S
T
A
T
A
T
V
T
M
Q
M
L
R
L
S
G
-
Y
I
P
I
A
T
C
-
S
P
H
N
F
D
L
A
K
S
R
G
A
E
E
V
F
D
Y
---------
R
A
P-----------------
N
-----------------------
L
------------------
A
Q
T
-----------------------
I
--
R
T
-
Y
T
--
K
N
N
L
R
Y
A
L
D
C
I
T
N
V
E
S
T
T
F
C
F
A
A
I
G
R
-
A
G
G
H
Y
V
S
L
--
N
P
F
P
E
--------TRKM
V
T
T
D
W
------------
T
L
GPT
I
F
G
E
G
-
S
-
T
W
P
A
P
Y
G
R
P
---
G
S
E
E
E
---------
R
Q
F
G
E
D
L
W
R
I
A
G
Q
L
V
E
D
G
R
L
V
H
H
P
LR
V
--------
V
---
Q
G
-
G
F
--
D
H
I
K
Q
G
M
E
L
V
R
K
G
E
-
L
-
S
G
E
K
L
V
V
R
L
-
68
Fugue
52.31
25%
6
- C2 -
-
2VN8
2
RT4I1_HUMAN
A:
[18-375]
L
Y
F
Q
S
M
A
W
V
I
--
D
--
K
Y
G
------------
K
N
E
V
L
R
F
T
Q
N
-
M
M
M
P
I
I
-
H
Y
P
N
E
V
I
V
K
V
H
A
A
S
V
N
P
I
D
V
N
M
R
-
S
G
Y
----------------
G
-
A
-----
T
----------
A
L
N
M
-
K
R
DPLHVKIKGEEFP
L
T
L
G
R
D
V
S
G
V
V
M
E
C
G
L
D
V
-
K
----
Y
F
K
P
G
D
E
V
-------------
W
A
A
V
P
P
--------------------------
W
-----------
K
Q
G
T
L
S
E
F
V
V
V
S
G
N
E
V
S
H
K
P
K
S
L
T
H
T
Q
A
A
S
L
P
Y
V
A
L
T
A
W
S
A
I
N
K
--
V
--
G
--
G
L
------------
N
D
---
K
N
C
-
T
G
--
K
R
V
L
I
L
G
A
S
G
G
V
G
T
F
A
I
Q
V
M
K
A
W
-
D
A
H
V
T
A
V
C
S
-
Q
D
A
S
E
L
V
R
K
L
G
A
D
D
V
I
D
Y
---------
K
S
------------------
G
------------------------------------------
S
V
E
-----------------------
E
--
Q
L
-
K
S
--
L
K
P
F
D
F
I
L
D
N
V
G
G
S
T
E
T
W
A
P
D
F
L
K
-
K
W
S
G
A
T
Y
V
T
L
--
V
T
P
F
L
L
---
N
--
M
--------
D
------------
R
----
L
G
I
A
D
-
G
-
M
L
Q
T
G
V
T
V
G
S
K
A
L
K
H
F
W
K
G
V
H
Y
R
W
A
F
F
M
A
S
G
P
C
L
D
D
I
A
E
L
V
D
A
G
K
I
R
P
V
I
--
E
--------
Q
---
T
F
P
---
F
S
K
V
P
E
A
F
L
K
V
E
R
G
H
-
A
-
R
G
-
K
T
V
I
N
V
V
77
HHSearch
51.96
21%
-2
* C2 *
-
4GI2
1
?
B:
[35-410]
----
M
Y
A
W
A
I
--
R
RE
R
H
G
------------
P
P
--
E
Q
S
H
Q
L
-
E
V
L
P
V
W
E
I
G
D
D
E
V
L
V
Y
V
M
A
A
G
V
N
Y
N
G
V
W
A
G
-
L
G
E
----------------
P
-
I
-----
S
PFDVH-----
K
G
E
Y
-
H
---------------
I
A
G
S
D
A
S
G
I
V
W
K
V
G
A
K
V
-
K
----
R
W
K
V
G
D
E
V
-------------
I
V
H
C
N
Q
DDGDDEECNGGDPMFSPT
Q
R
I
W
GYE-
T
-----------
G
D
G
S
F
A
Q
F
C
R
V
Q
S
R
Q
L
M
A
R
P
K
H
L
T
W
E
E
A
A
C
Y
T
L
T
L
A
T
A
Y
R
M
L
F
G
--
H
--
A
PH
T
V
------------
R
------
P
--
G
--
Q
N
V
L
I
W
G
A
S
G
G
L
G
V
F
G
V
Q
L
C
A
A
S
G
-
A
N
A
I
A
V
I
S
D
E
S
K
R
D
Y
V
M
S
L
G
A
K
G
V
I
N
R
---------
K
D
------------------
F
DCWGQLPTVNS
P
E
Y
N
T
W
L
K
E
A
R
K
F
------------------
G
K
A
-----------------------
I
--
W
D
-
I
T
GK
G
N
D
V
D
I
V
F
E
H
P
G
E
-
A
T
F
P
V
S
T
L
V
A
-
K
-
R
G
G
M
I
V
F
C
--
A
G
T
T
G
F
---
N
--
I
T
F
D
A
----
R
------------
Y
----
V
W
M
R
Q
-
K
-
R
I
Q
G
S
---------------------
H
F
A
H
L
K
Q
A
S
A
A
N
Q
F
V
M
D
R
R
V
D
P
C
M
--
S
--------
E
---
V
F
-
P
W
--
D
K
I
P
A
A
H
T
K
M
W
K
N
Q
-
H
P
P
G
-
N
M
A
V
L
V
-
80
HHSearch
51.31
21%
6
- C2 -
-
3KRT
-
?
D:
[31-420]
----
Y
R
A
I
T
V
--
H
--
K
D
E
TEMFAGLETRDK
D
P
--
R
K
S
I
H
L
-
D
D
V
P
V
P
E
L
G
P
G
E
A
L
V
A
V
M
A
S
S
V
N
Y
N
S
V
H
T
S
-
I
F
E
PLSTFGFLERYGR---
V
-
S
DLAKR
H
----------
D
L
P
Y
-
H
---------------
V
I
G
S
D
L
A
G
V
V
L
R
T
G
P
G
V
-
N
----
A
W
Q
A
G
D
E
V
-------------
V
A
H
C
L
S
VELESSDGHNDTMLDPEQRIWGFE--
T
-----------
N
F
G
G
L
A
E
I
A
L
V
K
S
N
Q
L
M
P
K
P
D
H
L
S
W
E
E
A
A
A
P
G
L
V
N
S
T
A
Y
R
Q
L
V
S
--
R
NG
A
--
G
M
------------
K
------
Q
--
G
--
D
N
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
T
Q
F
A
L
A
G
G
-
A
N
P
I
C
V
V
S
S
P
Q
K
A
E
I
C
R
A
M
G
A
E
A
I
I
D
R
---------
N
A
EGYRFWKDENTQDPKEWK
R
-----------------------
F
------------------
G
K
R
-----------------------
I
--
R
E
-
L
T
G-
G
E
D
I
D
I
V
F
E
H
P
G
R
-
E
T
F
G
A
S
V
F
V
T
-
R
-
K
G
G
T
I
T
T
C
--
A
S
T
S
G
Y
---
M
HE
Y
DN------
R
------------
Y
----
L
W
M
S
L
-
K
-
R
I
I
G
S
---------------------
H
F
A
N
Y
R
E
A
W
E
A
N
R
L
I
A
K
G
R
I
H
P
T
L
--
S
--------
K
---
V
Y
-
S
L
--
E
D
T
G
Q
A
A
Y
D
V
H
R
N
L
-
H
-
Q
G
-
K
V
G
V
L
--